Search our Database of Scientific Publications and Authors

I’m looking for a

    1631 results match your criteria Bipolar disorders[Journal]

    1 OF 33

    Assessing and addressing cognitive impairment in bipolar disorder: the International Society for Bipolar Disorders Targeting Cognition Task Force recommendations for clinicians.
    Bipolar Disord 2018 Jan 18. Epub 2018 Jan 18.
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
    Objectives: Cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. The International Society for Bipolar Disorders (ISBD) Targeting Cognition Task Force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and address cognitive impairment.

    Methods: The task force, consisting of 19 international experts from nine countries, discussed the challenges and recommendations in a face-to-face meeting, telephone conference call and email exchanges. Read More

    Prevalence of cognitive impairment in major depression and bipolar disorder.
    Bipolar Disord 2018 Jan 18. Epub 2018 Jan 18.
    Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
    Objectives: The current study examines prevalence of cognitive impairment in four mood disorder samples, using four definitions of impairment. The impact of premorbid IQ on prevalence was examined, and the influence of treatment response.

    Methods: Samples were: (i) 58 inpatients in a current severe depressive episode (unipolar or bipolar), (ii) 69 unmedicated outpatients in a mild to moderate depressive episode (unipolar or bipolar), (iii) 56 outpatients with bipolar disorder, in a depressive episode, and (iv) 63 outpatients with bipolar disorder, currently euthymic. Read More

    Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping.
    Bipolar Disord 2018 Jan 7. Epub 2018 Jan 7.
    Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
    Objectives: Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors, and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients vs healthy controls that were consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality. The current study built upon this prior work to investigate brain T1ρ differences across euthymic, depressed, and manic mood states of bipolar disorder. Read More

    Assessment of cognitive functions in bipolar I disorder: A 1-year naturalistic follow-up study.
    Bipolar Disord 2018 Jan 4. Epub 2018 Jan 4.
    Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India.
    Objective: Available findings from cross-sectional studies have demonstrated cognitive impairments in bipolar I disorder (BD-I) during various phases of illness. However, very little is known about the longitudinal course of these cognitive impairments. The purpose of the study was to explore the longitudinal pattern of changes in cognitive functioning of BD-I patients. Read More

    Systematic genetic analyses of genome-wide association study data reveal an association between the key nucleosome remodeling and deacetylase complex and bipolar disorder development.
    Bipolar Disord 2017 Dec 27. Epub 2017 Dec 27.
    Department of Psychiatry, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.
    Background: Genome-wide association studies (GWASs) are used to identify genetic variants for association with bipolar disorder (BD) risk; however, each GWAS can only reveal a small fraction of this association. This study systematically analyzed multiple GWAS data sets to provide further insights into potential causal BD processes by integrating the results of Psychiatric Genomics Consortium Phase I (PGC-I) for BD with core human pathways and functional networks.

    Methods: The i-Gsea4GwasV2 program was used to analyze data from the PGC-I GWAS for BD (the pathways came from Reactome), as well as the nominally significant pathways. Read More

    Three-year follow-up after psychotherapy for young people with bipolar disorder.
    Bipolar Disord 2017 Dec 22. Epub 2017 Dec 22.
    Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
    Objectives: (1) To examine the differences between interpersonal and social rhythm therapy (IPSRT) and specialist supportive care (SSC) in the longer term impacts of IPSRT and SSC on cumulative depression and mania symptoms over a further 78-week follow-up period post treatment. (2) To calculate the survival time before recurrence of a new mood episode over the 3-year period.

    Methods: One hundred young people with bipolar disorder aged between 15 and 36 years who had been randomized to treatment with either IPSRT or SSC for 78 weeks were followed up for a subsequent 78 weeks. Read More

    Right unilateral electroconvulsive therapy does not cause more cognitive impairment than pharmacologic treatment in treatment-resistant bipolar depression: A 6-month randomized controlled trial follow-up study.
    Bipolar Disord 2017 Dec 21. Epub 2017 Dec 21.
    Haukeland Universitetssjukehus, Bergen, Norway.
    Objectives: Electroconvulsive therapy is an effective treatment for bipolar depression, but there are concerns about whether it causes long-term neurocognitive impairment.

    Methods: In this multicenter randomized controlled trial, in-patients with treatment-resistant bipolar depression were randomized to either algorithm-based pharmacologic treatment or right unilateral electroconvulsive therapy. After the 6-week treatment period, all of the patients received maintenance pharmacotherapy as recommended by their clinician guided by a relevant treatment algorithm. Read More

    Risk of recurrence after a single manic or mixed episode - a systematic review and meta-analysis.
    Bipolar Disord 2017 Dec 14. Epub 2017 Dec 14.
    Department O, Psychiatric Center Copenhagen, Copenhagen, Denmark.
    Objectives: For the first time to estimate the risk of recurrence among patients with a single manic/mixed episode by systematically reviewing prior studies on cohorts of adults, and cohorts of children and adolescents, respectively.

    Methods: A systematic literature search up to August 2017 was carried out including studies in which < 25% of the participants were estimated to have had a mood episode that required pharmacological treatment prior to the index manic or mixed episode at inclusion.

    Results: Three studies including a total of 293 adult patients with a single manic or mixed episode and three studies of children and adolescents including 126 patients were identified. Read More

    The clinical course of late-life bipolar disorder, looking back and forward.
    Bipolar Disord 2017 Dec 11. Epub 2017 Dec 11.
    Department of Old Age Psychiatry, GGZinGeest, VUmc, Amsterdam, the Netherlands.
    Objectives: Little is known about the course of late-life bipolar disorder (LLBD). First, we studied patients with LLBD retrospectively with regard to age at first mood episode, onset polarity, predominant polarity and episode density and its associations with other clinical variables. Next, we examined prospectively the clinical course and its associated factors. Read More

    Patients with chronic bipolar disorder exhibit widespread increases in extracellular free water.
    Bipolar Disord 2017 Dec 11. Epub 2017 Dec 11.
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
    Objectives: Bipolar disorder (BP) is a debilitating psychiatric disease that is not well understood. Previous diffusion magnetic resonance imaging (dMRI) studies of BP patients found prominent microstructural white matter (WM) abnormalities of reduced fractional anisotropy (FA). Because FA is a nonspecific measure, relating these abnormalities to a specific pathology is difficult. Read More

    Eye gaze perception in bipolar disorder: Self-referential bias but intact perceptual sensitivity.
    Bipolar Disord 2017 Nov 23. Epub 2017 Nov 23.
    Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
    Objectives: Deficits in social cognition predict poor functional outcome in severe mental illnesses such as schizophrenia and autism. However, research findings on social cognition in bipolar disorder (BD) are sparse and inconsistent. This study aimed to characterize a critical social cognitive process-eye gaze perception-and examine its functional correlates in BD to inform psychopathological mechanisms. Read More

    Altered N170 and mood symptoms in bipolar disorder: An electrophysiological study of configural face processing.
    Bipolar Disord 2017 Nov 17. Epub 2017 Nov 17.
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
    Objectives: Altered social behavior during mood episodes in bipolar disorder often has detrimental and long-lasting interpersonal consequences. Abnormal face processing may play a role in linking brain functions to clinical symptoms and behavior. This study aimed to understand configural face processing in bipolar disorder as a function of basic communicative attributes of the face and mood symptoms using event-related brain potentials (ERPs). Read More

    Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study.
    Bipolar Disord 2017 Nov 9. Epub 2017 Nov 9.
    NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Objectives: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. Read More

    Unraveling the biology of bipolar disorder using induced pluripotent stem-derived neurons.
    Bipolar Disord 2017 Nov 8;19(7):544-551. Epub 2017 Nov 8.
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
    Objectives: Bipolar disorder has been studied from numerous angles, from pathological studies to large-scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder. Read More

    Measurement tools for assessment of older age bipolar disorder: A systematic review of the recent global literature.
    Bipolar Disord 2017 Nov 6. Epub 2017 Nov 6.
    Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
    Objectives: More than 50% of people with bipolar disorder will be age 60 years or older by 2030. There is a need for more data to guide assessment and treatment in older age bipolar disorder (OABD); however, interpretation of findings from small, single-site studies may not be generalizable and there are few large trials. As a step in the direction of coordinated large-scale OABD data collection, it is critical to identify which measurements are currently used and identify potential gaps in domains typically assessed. Read More

    Reduced electroencephalogram responses to standard and target auditory stimuli in bipolar disorder and the impact of psychotic features: Analysis of event-related potentials, spectral power, and inter-trial coherence.
    Bipolar Disord 2017 Oct 11. Epub 2017 Oct 11.
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
    Background: Bipolar disorder (BD) is associated with reductions in the P3b event-related potential (ERP) response to target auditory stimuli, which suggests deficits in context updating. Previous studies have typically examined these responses in the temporal domain, which may not capture alterations in specific frequencies of phase-locked or induced electrophysiological activity. Therefore, the present study examined early and late ERPs in temporal and frequency domains in a bipolar sample with and without current psychotic features. Read More

    Disrupted cortico-limbic connectivity during reward processing in remitted bipolar I disorder.
    Bipolar Disord 2017 Dec 11;19(8):661-675. Epub 2017 Oct 11.
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
    Objectives: Bipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well-known cortico-limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms.

    Methods: The present investigation employed a within- and between-subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non-psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI). Read More

    Changes in white matter microstructure predict lithium response in adolescents with bipolar disorder.
    Bipolar Disord 2017 Nov 9;19(7):587-594. Epub 2017 Oct 9.
    James J. Peters VA Medical Center, Bronx, NY, USA.
    Objectives: To investigate whether response to lithium treatment in pediatric bipolar disorder can be predicted by changes in white matter microstructure in key cortico-limbic tracts involved in emotion regulation.

    Methods: Eighteen clinically referred lithium-naive patients (mean age 15.5 years) were administered clinical rating scales and diffusion tensor imaging (DTI) examinations at baseline and following 4 weeks of lithium treatment. Read More

    Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients.
    Bipolar Disord 2017 Sep 27;19(6):487-495. Epub 2017 Sep 27.
    Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany.
    Objectives: The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients. Read More

    The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.
    Bipolar Disord 2017 Nov 25;19(7):524-543. Epub 2017 Sep 25.
    Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC, USA.
    Objectives: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings.

    Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps. Read More

    Obesity and frontal-striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative.
    Bipolar Disord 2017 Sep 25. Epub 2017 Sep 25.
    Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
    Objectives: To compare frontal-striatal brain volumes between offspring of individuals with bipolar disorder (BD) and healthy controls; to investigate the associations of body mass index (BMI) and age with brain volumes; and to assess the moderating effects of BMI and age on the relationship between risk status and structural brain differences.

    Methods: We cross-sectionally assessed structural regional and global brain volumes using magnetic resonance imaging and BMI among 53 BD offspring subjects, stratified by risk status, and 23 non-BD offspring controls (aged 8-28 years). Analyses of variance and covariance and linear regression analyses were conducted to investigate the associations between BMI and measures of brain volume, as well as the interaction effects between age, BMI, and risk status on brain volumes. Read More

    Outcomes for bipolar patients assessed in the French expert center network: A 2-year follow-up observational study (FondaMental Advanced Centers of Expertise for Bipolar Disorder [FACE-BD]).
    Bipolar Disord 2017 Dec 12;19(8):651-660. Epub 2017 Sep 12.
    Fondation FondaMental, Fondation de Coopération Scientifique, Créteil, France.
    Objective: A new health care system for patients with bipolar disorders was established in France under the auspices of Fondation FondaMental, based on thorough clinical assessment of patients and on close collaborations between expert centers and referring practitioners. We report the results of outcomes after 2 years of observational follow-up of adult patients assessed within the network.

    Method: A total of 984 patients were included in the study. Read More

    1 OF 33