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    1599 results match your criteria Bipolar disorders[Journal]

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    Altered N170 and mood symptoms in bipolar disorder: An electrophysiological study of configural face processing.
    Bipolar Disord 2017 Nov 17. Epub 2017 Nov 17.
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
    Objectives: Altered social behavior during mood episodes in bipolar disorder often has detrimental and long-lasting interpersonal consequences. Abnormal face processing may play a role in linking brain functions to clinical symptoms and behavior. This study aimed to understand configural face processing in bipolar disorder as a function of basic communicative attributes of the face and mood symptoms using event-related brain potentials (ERPs). Read More

    Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study.
    Bipolar Disord 2017 Nov 9. Epub 2017 Nov 9.
    NORMENT KG Jebsen Centre for Psychosis Research, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Objectives: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. Read More

    Unraveling the biology of bipolar disorder using induced pluripotent stem-derived neurons.
    Bipolar Disord 2017 Nov 8. Epub 2017 Nov 8.
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
    Objectives: Bipolar disorder has been studied from numerous angles, from pathological studies to large-scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder. Read More

    Measurement tools for assessment of older age bipolar disorder: A systematic review of the recent global literature.
    Bipolar Disord 2017 Nov 6. Epub 2017 Nov 6.
    Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
    Objectives: More than 50% of people with bipolar disorder will be age 60 years or older by 2030. There is a need for more data to guide assessment and treatment in older age bipolar disorder (OABD); however, interpretation of findings from small, single-site studies may not be generalizable and there are few large trials. As a step in the direction of coordinated large-scale OABD data collection, it is critical to identify which measurements are currently used and identify potential gaps in domains typically assessed. Read More

    Reduced electroencephalogram responses to standard and target auditory stimuli in bipolar disorder and the impact of psychotic features: Analysis of event-related potentials, spectral power, and inter-trial coherence.
    Bipolar Disord 2017 Oct 11. Epub 2017 Oct 11.
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
    Background: Bipolar disorder (BD) is associated with reductions in the P3b event-related potential (ERP) response to target auditory stimuli, which suggests deficits in context updating. Previous studies have typically examined these responses in the temporal domain, which may not capture alterations in specific frequencies of phase-locked or induced electrophysiological activity. Therefore, the present study examined early and late ERPs in temporal and frequency domains in a bipolar sample with and without current psychotic features. Read More

    Disrupted cortico-limbic connectivity during reward processing in remitted bipolar I disorder.
    Bipolar Disord 2017 Oct 11. Epub 2017 Oct 11.
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
    Objectives: Bipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well-known cortico-limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms.

    Methods: The present investigation employed a within- and between-subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non-psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI). Read More

    Changes in white matter microstructure predict lithium response in adolescents with bipolar disorder.
    Bipolar Disord 2017 Oct 9. Epub 2017 Oct 9.
    James J. Peters VA Medical Center, Bronx, NY, USA.
    Objectives: To investigate whether response to lithium treatment in pediatric bipolar disorder can be predicted by changes in white matter microstructure in key cortico-limbic tracts involved in emotion regulation.

    Methods: Eighteen clinically referred lithium-naive patients (mean age 15.5 years) were administered clinical rating scales and diffusion tensor imaging (DTI) examinations at baseline and following 4 weeks of lithium treatment. Read More

    Debate on "Defining melancholia: A core mood disorder".
    Bipolar Disord 2017 Oct 7. Epub 2017 Oct 7.
    Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
    Objectives: Recently, a debate article by Parker et al. was published regarding the biological type of depression, melancholia, in which they discussed its clinical presentation, particularly that involving psychomotor disturbances. However, there is one feature of melancholia that is frequently forgotten, to which this article aims to devote special attention: ruminative thoughts of guilt. Read More

    Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients.
    Bipolar Disord 2017 Sep 27;19(6):487-495. Epub 2017 Sep 27.
    Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Mainz, Germany.
    Objectives: The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients. Read More

    The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.
    Bipolar Disord 2017 Sep 25. Epub 2017 Sep 25.
    Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC, USA.
    Objectives: Over the past two decades, there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (ie, pediatric BD [PBD]). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in the field, and disseminate clinically relevant findings.

    Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps. Read More

    Obesity and frontal-striatal brain structures in offspring of individuals with bipolar disorder: Results from the global mood and brain science initiative.
    Bipolar Disord 2017 Sep 25. Epub 2017 Sep 25.
    Department of Affective Disorders, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
    Objectives: To compare frontal-striatal brain volumes between offspring of individuals with bipolar disorder (BD) and healthy controls; to investigate the associations of body mass index (BMI) and age with brain volumes; and to assess the moderating effects of BMI and age on the relationship between risk status and structural brain differences.

    Methods: We cross-sectionally assessed structural regional and global brain volumes using magnetic resonance imaging and BMI among 53 BD offspring subjects, stratified by risk status, and 23 non-BD offspring controls (aged 8-28 years). Analyses of variance and covariance and linear regression analyses were conducted to investigate the associations between BMI and measures of brain volume, as well as the interaction effects between age, BMI, and risk status on brain volumes. Read More

    Outcomes for bipolar patients assessed in the French expert center network: A 2-year follow-up observational study (FondaMental Advanced Centers of Expertise for Bipolar Disorder [FACE-BD]).
    Bipolar Disord 2017 Sep 12. Epub 2017 Sep 12.
    Fondation FondaMental, Fondation de Coopération Scientifique, Créteil, France.
    Objective: A new health care system for patients with bipolar disorders was established in France under the auspices of Fondation FondaMental, based on thorough clinical assessment of patients and on close collaborations between expert centers and referring practitioners. We report the results of outcomes after 2 years of observational follow-up of adult patients assessed within the network.

    Method: A total of 984 patients were included in the study. Read More

    Are patients with bipolar disorder and comorbid attention-deficit hyperactivity disorder more neurocognitively impaired?
    Bipolar Disord 2017 Sep 21. Epub 2017 Sep 21.
    ADHD Program, Department of Psychiatry, Hospital Universitari Vall d'Hebron, CIBERSAM, Barcelona, Catalonia, Spain.
    Objective: Research on neurocognitive impairment in adult patients with comorbid bipolar disorder (BD) and attention-deficit hyperactivity disorder (ADHD) is very scarce. This study assessed the neurocognitive profile of a comorbid group (BD+ADHD) compared with that of pure BD (pBD) group, pure ADHD (pADHD) group and healthy controls (HCs).

    Methods: This was a three-site study comprising 229 subjects: 70 patients with pBD, 23 with BD+ADHD, 50 with pADHD, and 86 HCs. Read More

    Equivalent linear change in cognition between individuals with bipolar disorder and healthy controls over 5 years.
    Bipolar Disord 2017 Sep 14. Epub 2017 Sep 14.
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
    Objectives: Cognitive dysfunction is a key feature of bipolar disorder (BD). However, not much is known about its temporal stability, as some studies have demonstrated a neurodegenerative model in BD while others have shown no change in cognitive functioning over time. Building upon our prior work, which examined the natural course of executive functioning, the current study aimed to investigate the natural course of memory, emotion processing, and fine motor dexterity over a 5-year period in BD and healthy control (HC) samples. Read More

    Systemic challenges in bipolar disorder management: A patient-centered approach.
    Bipolar Disord 2017 Sep 13. Epub 2017 Sep 13.
    Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
    Objectives: As part of a series of Patient-Centered Outcomes Research Institute-funded large-scale retrospective observational studies on bipolar disorder (BD) treatments and outcomes, we sought the input of patients with BD and their family members to develop research questions. We aimed to identify systemic root causes of patient-reported challenges with BD management in order to guide subsequent studies and initiatives.

    Methods: Three focus groups were conducted where patients and their family members (total n = 34) formulated questions around the central theme, "What do you wish you had known in advance or over the course of treatment for BD?" In an affinity mapping exercise, participants clustered their questions and ranked the resulting categories by importance. Read More

    Methodological recommendations for cognition trials in bipolar disorder by the International Society for Bipolar Disorders Targeting Cognition Task Force.
    Bipolar Disord 2017 Sep 12. Epub 2017 Sep 12.
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
    Objectives: To aid the development of treatment for cognitive impairment in bipolar disorder, the International Society for Bipolar Disorders (ISBD) convened a task force to create a consensus-based guidance paper for the methodology and design of cognition trials in bipolar disorder.

    Methods: The task force was launched in September 2016, consisting of 18 international experts from nine countries. A series of methodological issues were identified based on literature review and expert opinion. Read More

    Lithium reduces the span of G protein-activated K(+) (GIRK) channel inhibition in hippocampal neurons.
    Bipolar Disord 2017 Sep 12. Epub 2017 Sep 12.
    Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
    Objectives: Lithium (Li(+) ) is one of the most widely used treatments for bipolar disorder (BD). However, the molecular and neuronal basis of BD, as well as the mechanisms of Li(+) actions are poorly understood. Cellular and biochemical studies identified G proteins as being among the cellular targets for Li(+) action, while genetic studies indicated an association with the KCNJ3 gene, which encodes the G protein-activated inwardly rectifying K(+) (GIRK) channels. Read More

    Relationships between corpus callosum and language lateralization in patients with schizophrenia and bipolar disorders.
    Bipolar Disord 2017 Sep 23;19(6):496-504. Epub 2017 Aug 23.
    Service de Psychiatrie, CHU de Caen, Caen, France.
    Objectives: The question of whether there is a continuum or a dichotomy among patients with schizophrenia (SZ) and bipolar disorders (BD) has not been clearly resolved and remains a challenge. Thus, the identification of specific biomarkers of these disorders might be helpful. The present study investigated the volume of the corpus callosum (CC) and functional lateralization for language as potential biomarkers and their relationships in SZ and BD. Read More

    Psychosis in bipolar disorder: Does it represent a more "severe" illness?
    Bipolar Disord 2017 Aug 23. Epub 2017 Aug 23.
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
    Objectives: Although there is a common clinical assumption that bipolar disorder with psychotic features reflects greater severity than bipolar disorder without psychosis, the existing empirical literature is mixed. This study investigated the phenomenology of psychosis as well as demographic, clinical, functional, and neuropsychological features in a large, cross-sectional sample of participants with bipolar disorder divided by history of psychosis.

    Methods: In a large single study, 168 affective-only bipolar disorder (BP-A) participants and 213 bipolar disorder with a history of psychosis (BP-P) participants completed a comprehensive clinical diagnostic interview and neuropsychological testing. Read More

    Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial.
    Bipolar Disord 2017 Sep 20;19(6):477-486. Epub 2017 Aug 20.
    Department of Psychiatry, University of Oxford, Oxford, UK.
    Objectives: CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid versus placebo] in bipolar depression) was a double-blind, randomized, placebo-controlled, parallel group, 2×2 factorial trial that examined the effect of adding lamotrigine and/or folic acid (FA) to quetiapine in bipolar depression. Lamotrigine improved depression, but its effectiveness was reduced by FA. We investigated the baseline predictors and correlates of clinical response, and the possible basis of the interaction. Read More

    Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder.
    Bipolar Disord 2017 Aug 23. Epub 2017 Aug 23.
    Department of Psychiatry, Penn State Milton S Hershey Medical Center, Hershey, PA, USA.
    Objective: Chronic, low-level inflammation is associated with symptomatic bipolar disorder (BD) and with chronic insomnia. Disrupted sleep is a feature of episodes of both mania and depression. We examined the effect of neopterin, a marker of cellular immune activation, and kynurenine (KYN), an inflammatory byproduct of the serotonin pathway, on the association between total sleep time and depression severity in BD. Read More

    Cortical inhibition in symptomatic and remitted mania compared to healthy subjects: A cross-sectional study.
    Bipolar Disord 2017 Aug 23. Epub 2017 Aug 23.
    Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
    Objectives: Transcranial magnetic stimulation (TMS)-derived cortical reactivity studies provide a unique opportunity to non-invasively study gamma amino butyric acid (GABA)-mediated inhibitory neurotransmission in bipolar disorder (BD). Earlier studies were conducted in smaller samples and on patients who were on medications that can potentially confound the results. We aimed to study short-interval (SICI) and long-interval intracortical inhibition (LICI) in medication-naïve/free symptomatic (manic) BD patients (n=39), first episode mania (FEM) patients who had recently (≤6 months) remitted with treatment (remitted FEM; n = 28) and healthy subjects (HSs; n = 45). Read More

    Characterizing the experience of auditory verbal hallucinations and accompanying delusions in individuals with a diagnosis of bipolar disorder: A systematic review.
    Bipolar Disord 2017 Sep 14;19(6):417-433. Epub 2017 Aug 14.
    Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
    Objectives: The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psychotic symptoms.

    Methods: A comprehensive synthesis of findings on the phenomenology of AVH and delusions in BD is included, alongside a critical review of clinical and cognitive correlates. Studies published in the previous 20 years, until December 2016, were retrieved from the following databases: Embase, CINAHL, MEDLINE, PsycINFO and Web of Science. Read More

    White matter tract integrity is associated with antidepressant response to lurasidone in bipolar depression.
    Bipolar Disord 2017 Sep 10;19(6):444-449. Epub 2017 Aug 10.
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Objectives: Patients with bipolar disorder spend the most time in the depressed phase, and that phase is associated with the most morbidity and mortality. Treatment of bipolar depression lacks a test to determine who will respond to treatment. White matter disruptions have been found in bipolar disorder. Read More

    Menopause and illness course in bipolar disorder: A systematic review.
    Bipolar Disord 2017 Sep 10;19(6):434-443. Epub 2017 Aug 10.
    Clinical and Health Psychology Research Initiative (CaHPRI), School of Social Sciences and Psychology, Western Sydney University, Sydney, NSW, Australia.
    Objectives: Menopause may be a time of increased mood symptoms for some women. This systematic review aimed to examine the severity of symptoms and prevalence of mood changes in women with bipolar disorder during peri-menopause and post-menopause.

    Methods: A systematic review was undertaken in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

    Differential failure to deactivate the default mode network in unipolar and bipolar depression.
    Bipolar Disord 2017 Aug 17;19(5):386-395. Epub 2017 Jul 17.
    FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
    Objectives: Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly.

    Methods: Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healthy controls underwent functional magnetic resonance imaging (fMRI) while performing the n-back working memory task. Read More

    Rate and predictors of conversion from unipolar to bipolar disorder: A systematic review and meta-analysis.
    Bipolar Disord 2017 Aug 17;19(5):324-335. Epub 2017 Jul 17.
    Psychiatric Center Copenhagen, Department O and University of Copenhagen, Copenhagen, Denmark.
    Objectives: For the first time to present a systematic review and meta-analysis of the conversion rate and predictors of conversion from unipolar disorder to bipolar disorder.

    Methods: A systematic literature search up to October 2016 was performed. For the meta-analysis, we only included studies that used survival analysis to estimate the conversion rate. Read More

    Evidence that eye-movement profiles do not explain slow binocular rivalry rate in bipolar disorder: support for a perceptual endophenotype.
    Bipolar Disord 2017 Sep 17;19(6):465-476. Epub 2017 Jul 17.
    Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School and The Alfred Hospital, Melbourne, Australia.
    Objectives: Presenting conflicting images simultaneously, one to each eye, produces perceptual alternations known as binocular rivalry (BR). Slow BR rate has been proposed as an endophenotype for bipolar disorder (BD) for use in large-scale genome-wide association studies. However, the trait could conceivably reflect eye movement (EM) dysfunction in BD rather than anomalous perceptual processing per se. Read More

    Phenotypical characteristics of postpartum psychosis: A clinical cohort study.
    Bipolar Disord 2017 Sep 12;19(6):450-457. Epub 2017 Jul 12.
    Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.
    Objectives: Postpartum psychosis (PP) is known for its clear onset but its phenotype has never been clearly described in a cohort. The aim of this study was to describe PP symptomatology, and to identify subgroups of patients based on symptom profiles.

    Methods: We prospectively assessed a wide range of symptoms in cases of PP in a cohort of women (N=130) admitted to the Mother-Baby inpatient unit. Read More

    Amygdala and hippocampus volumes are differently affected by childhood trauma in patients with bipolar disorders and healthy controls.
    Bipolar Disord 2017 Aug 12;19(5):353-362. Epub 2017 Jul 12.
    IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Rome, Italy.
    Objectives: Volumetric studies on deep gray matter structures in bipolar disorder (BP) have reported contrasting results. Childhood trauma, a relevant environmental stressor for BP, could account for the variability of the results, modulating differences in the amygdala and hippocampus in patients with BP compared with healthy controls (HC). Our study aimed to test this hypothesis. Read More

    Impact of childhood trauma on cognitive profile in bipolar disorder.
    Bipolar Disord 2017 Aug 10;19(5):363-374. Epub 2017 Jul 10.
    Bipolar Disorder Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
    Objectives: Bipolar Disorder (BD) is associated with cognitive impairment even during remission periods. Nonetheless, this impairment seems to adjust to different profiles of severity. Our aim was to examine the potential impact of childhood trauma (CT) on cognitive performance and, more specifically, on neurocognitive profile membership. Read More

    Cognitive function, treatment response to lithium, and social functioning in Japanese patients with bipolar disorder.
    Bipolar Disord 2017 Jul 10. Epub 2017 Jul 10.
    Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
    Objectives: Patients with bipolar disorder often suffer from cognitive impairment that significantly influences their functional outcome. However, it remains unknown whether lithium has a central role in cognition and functional outcome. We examined whether cognition and functional outcome were predicted by demographic and clinical variables, including the response to lithium, in lithium-treated patients with bipolar disorder. Read More

    Obesity in patients with major depression is related to bipolarity and mixed features: evidence from the BRIDGE-II-Mix study.
    Bipolar Disord 2017 Sep 10;19(6):458-464. Epub 2017 Jul 10.
    University of Pisa, Pisa, Italy.
    Objectives: The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-Mix study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions. The present post-hoc analysis evaluated the association between obesity and the presence of mixed features and bipolarity.

    Methods: A total of 2811 MDE subjects were enrolled in a multicenter cross-sectional study. Read More

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