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    1673 results match your criteria Bipolar disorders[Journal]

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    Double trouble: weekend sleep changes are associated with increased impulsivity among adolescents with bipolar I disorder.
    Bipolar Disord 2018 May 20. Epub 2018 May 20.
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
    Objectives: Both sleep disruption and impulsivity are important predictors of the course of bipolar disorder (BD). Although sleep disruption has been shown to intensify impulsivity, little research has considered how these two important domains interact within BD. Adolescence is a critical period for the onset of BD, and is often associated with increases in impulsivity and substantial changes in sleep. Read More

    Cognitive and functional deficits in bipolar disorder and schizophrenia as a function of the presence and history of psychosis.
    Bipolar Disord 2018 May 18. Epub 2018 May 18.
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida.
    Objectives: Schizophrenia and bipolar disorder overlap considerably. Schizophrenia is a primary psychotic disorder, whereas approximately half of people with bipolar disorder will experience psychosis. In this study, we examined the extent to which cognitive and functional impairments are related to the presence and history of psychosis across the two disorders. Read More

    Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial.
    Bipolar Disord 2018 Apr 25. Epub 2018 Apr 25.
    Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Objective: Immunological abnormalities play a role in the pathophysiology of mania and have been associated with relapse. Probiotic organisms such as Lactobacilli and Bifidobacteria modulate inflammation in humans and animal models. The trial examined whether the administration of probiotic organisms prevents psychiatric rehospitalizations in patients recently discharged following hospitalization for mania. Read More

    Plasma glutathione suggests oxidative stress is equally present in early- and late-onset bipolar disorder.
    Bipolar Disord 2018 Mar 30. Epub 2018 Mar 30.
    Department of Psychiatry and Oxford Health NHS Trust, Warneford Hospital, University of Oxford, Oxford, UK.
    Objectives: We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxidant. In this study, we sought to replicate these findings in a new cohort of patients.

    Methods: We recruited bipolar patients from Warneford Hospital, Oxford, UK, of similar age and grouped them according to age of onset of illness. Read More

    Genes involved in stress response influence lithium efficacy in bipolar patients.
    Bipolar Disord 2018 Mar 26. Epub 2018 Mar 26.
    Deparment of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
    Objectives: In mood disorders, chronic stimulation with stress results in aberrant regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Lithium was shown to influence HPA axis function. The underlying genetic background as well as environmental context may influence the stress response, and therefore lithium efficacy. Read More

    Psychoeducation for psychiatric inpatients following remission of a manic episode in bipolar I disorder: A randomized controlled trial.
    Bipolar Disord 2018 Mar 26. Epub 2018 Mar 26.
    Academic Department of Psychiatry, Northern Sydney Health District, St Leonards, NSW, Australia.
    Objective: The aim of the present study was to evaluate the effectiveness of psychoeducation for bipolar I inpatients following remission of a manic episode in a Chinese population.

    Method: The study recruited currently medicated bipolar I patients, aged 18-60 years, who were in remission from a manic episode, as determined using the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5). Patients were randomized (1:1) to either eight sessions of group-based psychoeducation (active treatment group) or regular free discussions (control group). Read More

    Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder.
    Bipolar Disord 2018 Mar 14;20(2):97-170. Epub 2018 Mar 14.
    Deakin Univeristy, IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Geelong, Vic., Australia.
    The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD). These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments. Read More

    Randomized trial comparing caregiver-only family-focused treatment to standard health education on the 6-month outcome of bipolar disorder.
    Bipolar Disord 2018 Mar 12. Epub 2018 Mar 12.
    Division of Child & Adolescent Psychiatry, UCLA Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
    Objectives: Caregivers of people with bipolar disorder often have depression and health problems. This study aimed to evaluate the sustained effects of a 12-15 week psychoeducational intervention on the health and mental health of caregivers of persons with bipolar disorder. We also evaluated the effects of the intervention on patients' mood symptoms over 6 months post-treatment. Read More

    Racial disparities in bipolar disorder treatment and research: a call to action.
    Bipolar Disord 2018 Mar 12. Epub 2018 Mar 12.
    Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
    Objectives: Health disparities between individuals of African and European ancestry are well documented. The disparities in bipolar disorder may be driven by racial bias superimposed on established factors contributing to misdiagnosis, including: evolving empirically based diagnostic criteria (International Classification of Diseases [ICD], Research Diagnostic Criteria [RDC] and Diagnostic and Statistical Manual [DSM]), multiple symptom domains (i.e. Read More

    Lower levels of brain-derived neurotrophic factor are associated with melancholic psychomotor retardation among depressed inpatients.
    Bipolar Disord 2018 Mar 8. Epub 2018 Mar 8.
    Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
    Objectives: Melancholic depression is a type of depression which is closely related to biological variables than are other types of depression. Its clinical features can be assessed using six items on the Hamilton Depression Rating Scale (HAM-D ). Previous studies have shown, using item response theory, that the symptom depressed mood is the least severe melancholic feature; work and activities, somatic symptoms and psychic anxiety are of moderate severity; and feelings of guilt and psychomotor retardation are the most severe. Read More

    Cardiometabolic risks and omega-3 index in recent-onset bipolar I disorder.
    Bipolar Disord 2018 Feb 26. Epub 2018 Feb 26.
    Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
    Objectives: The aims of the present study were to characterize cardiometabolic risk factors in a cohort of bipolar disorder patients with limited exposure to psychotropic medications, and to evaluate their associations with mood symptoms and omega-3 polyunsaturated fatty acid (PUFA) blood levels.

    Methods: Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication free at assessment and had no or limited exposure to mood-stabilizer or antipsychotic medications prior to the current admission. Read More

    Initiation and long-term use of benzodiazepines and Z-drugs in bipolar disorder.
    Bipolar Disord 2018 Feb 16. Epub 2018 Feb 16.
    Centre for Pharmacoepidemiology (CPE), Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Objectives: Increasing evidence points to the harmful effects of long-term benzodiazepine treatment. Our objective was to study the incidence of, and predictors for, long-term use of benzodiazepines and Z-drugs in bipolar disorder.

    Methods: We conducted a population-based cohort study, using data from Swedish national registers. Read More

    Clinical staging model in offspring of parents with bipolar disorder: a systematic review.
    Bipolar Disord 2018 Feb 15. Epub 2018 Feb 15.
    Department of Clinical and Health Psychology, University of Edinburgh, Edinburgh, UK.
    Objective: We sought to systematically review the literature on the psychiatric risk of offspring of parents with bipolar disorder (OPBD) using a developmental psychopathology framework. The review also sought to establish the utility of clinical stage modelling as a framework for identifying precursor disorders to later onset of bipolar disorder (BD) in OPBD.

    Methods: A systematic search was performed using EMBASE, PsychINFO and Medline. Read More

    Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies.
    Bipolar Disord 2018 Feb 14. Epub 2018 Feb 14.
    University Department of Psychiatry and Oxford Health NHS Foundation Trust, University of Oxford, Warneford Hospital, Oxford, UK.
    Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination.

    Methods: As part of the International Society for Bipolar Disorders (ISBD) Task Force on Lithium Treatment, we undertook a systematic literature search of non-randomized controlled observational studies on (i) lithium monotherapy vs treatment with another maintenance mood stabilizer in monotherapy and (ii) lithium in combination with other mood stabilizers vs monotherapy.

    Results: In eight out of nine identified studies including a total of < 14 000 patients, maintenance lithium monotherapy was associated with improved outcome compared with another mood stabilizer in monotherapy, including valproate, lamotrigine, olanzapine, quetiapine, unspecified anticonvulsants, carbamazepine/lamotrigine, unspecified atypical antipsychotics and unspecified antipsychotics. Read More

    Olfactory processing in bipolar disorder, major depression, and anxiety.
    Bipolar Disord 2018 Feb 13. Epub 2018 Feb 13.
    Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
    Objectives: Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in individuals with bipolar I disorder (n = 43; n = 13 with psychotic features), bipolar II disorder (n = 48), major depressive disorder (MDD) (n = 134), anxiety (n = 48), and no mental disorder (n = 72) who participated in a community-based family study.

    Methods: Best estimate DSM-IV diagnoses were based on in-depth personal interviews as well as interviews with family members. Read More

    Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations.
    Bipolar Disord 2018 Feb 13. Epub 2018 Feb 13.
    Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
    Objectives: We aimed to investigate morphometric correlates of auditory hallucinations in bipolar disorder (BD) by comparing cortical thickness and cortical surface area in bipolar disorder patients with (BD+) and without (BD-) a lifetime history of auditory hallucinations. Based on previous findings in schizophrenia patients, we hypothesized that the cortex would be thinner in the auditory cortex in BD+ compared to BD-.

    Methods: Bipolar disorder spectrum (n = 157) patients and healthy controls (n = 279) underwent 1. Read More

    Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder.
    Bipolar Disord 2018 Feb 13. Epub 2018 Feb 13.
    Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaíba, Brazil.
    Objectives: The objective of this study was to present a broad view of how genetic polymorphisms in genes that control the rhythmicity and function of circadian rhythm may influence the etiology, pathophysiology and treatment of bipolar disorder (BD).

    Methods: A bibliographic search was performed to identify and select papers reporting studies on variations in circadian genes and BD. A search of Medline, Google Scholar, Scopus, and Web of Science was carried out to review the literature. Read More

    Cognitive control under stressful conditions in transitional age youth with bipolar disorder: Diagnostic and sleep-related differences in fronto-limbic activation patterns.
    Bipolar Disord 2018 May 13;20(3):238-247. Epub 2018 Feb 13.
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Objectives: Adults with bipolar disorder (BD) display aberrant activation in fronto-limbic neural circuitry during cognitive control. However, fronto-limbic response to cognitive control, and factors destabilizing this circuitry, remain under-studied during the transition from adolescence to young adulthood in BD. Sleep patterns are disturbed in BD, undergo change in adolescence, and support brain function. Read More

    Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression: a systematic review and meta-analysis.
    Bipolar Disord 2018 May 14;20(3):195-227. Epub 2018 Feb 14.
    Section of Psychiatry, Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy.
    Background: Treatment-emergent mania (TEM) represents a common phenomenon inconsistently reported across primary studies, warranting further assessment.

    Methods: A systematic review and meta-analysis following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) and Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines were conducted. Major electronic databases were searched from inception to May 2017 to assess the incidence and prevalence rates and clinical features associated with manic switch among bipolar depressed patients receiving antidepressants, using meta-regression and subgroup analysis. Read More

    Altered frontal-amygdala effective connectivity during effortful emotion regulation in bipolar disorder.
    Bipolar Disord 2018 Feb 11. Epub 2018 Feb 11.
    Department of Psychiatry, Mood and Anxiety Disorders, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Objectives: Sufficient prefrontal top-down control of limbic affective areas, especially the amygdala, is essential for successful effortful emotion regulation (ER). Difficulties in effortful ER have been seen in patients with bipolar disorder (BD), which could be suggestive of a disturbed prefrontal-amygdala regulation circuit. The aim of this study was to investigate whether BD patients show abnormal effective connectivity from the prefrontal areas to the amygdala during effortful ER (reappraisal). Read More

    An update on adjunctive treatment options for bipolar disorder.
    Bipolar Disord 2018 Mar 25;20(2):87-96. Epub 2018 Jan 25.
    IMPACT Strategic Research Centre, Deakin University, Geelong, Vic., Australia.
    Objectives: Bipolar disorder is a complex illness often requiring combinations of therapies to successfully treat symptoms. In recent years, there have been significant advancements in a number of therapies for bipolar disorder. It is therefore timely to provide an overview of current adjunctive therapeutic options to help treating clinicians to inform their patients and work towards optimal outcomes. Read More

    Prevalence of axis II comorbidities in bipolar disorder: relationship to mood state.
    Bipolar Disord 2018 Jan 25. Epub 2018 Jan 25.
    Biostatistician UCLA Mood Disorders Research Program and VA Medical Center, Los Angeles, CA, USA.
    Objectives: A high incidence of Axis II personality disorders is described in patients with bipolar disorder; however, their relationship to mood state remains uncertain.

    Methods: A total of 966 outpatients with bipolar disorder gave informed consent and filled out the Personality Disorder Questionnaire, 4th edition (PDQ4) and a questionnaire on demographics and course of illness prior to Bipolar Treatment Outcome Network entry at average age 41 years. Patients were rated at each visit for depression on the Inventory of Depressive Symptoms-Clinician version (IDS-C) and for mania on the Young Mania Rating Scale (YMRS). Read More

    Assessing and addressing cognitive impairment in bipolar disorder: the International Society for Bipolar Disorders Targeting Cognition Task Force recommendations for clinicians.
    Bipolar Disord 2018 May 18;20(3):184-194. Epub 2018 Jan 18.
    Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
    Objectives: Cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. The International Society for Bipolar Disorders (ISBD) Targeting Cognition Task Force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and address cognitive impairment.

    Methods: The task force, consisting of 19 international experts from nine countries, discussed the challenges and recommendations in a face-to-face meeting, telephone conference call and email exchanges. Read More

    Prevalence of cognitive impairment in major depression and bipolar disorder.
    Bipolar Disord 2018 May 18;20(3):260-274. Epub 2018 Jan 18.
    Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
    Objectives: The current study examines prevalence of cognitive impairment in four mood disorder samples, using four definitions of impairment. The impact of premorbid IQ on prevalence was examined, and the influence of treatment response.

    Methods: Samples were: (i) 58 inpatients in a current severe depressive episode (unipolar or bipolar), (ii) 69 unmedicated outpatients in a mild to moderate depressive episode (unipolar or bipolar), (iii) 56 outpatients with bipolar disorder, in a depressive episode, and (iv) 63 outpatients with bipolar disorder, currently euthymic. Read More

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