73,997 results match your criteria Bipolar Affective Disorder


The association between comorbid psychiatric diagnoses and hospitalization-related factors among individuals with schizophrenia.

Compr Psychiatry 2018 Dec 7;89:7-15. Epub 2018 Dec 7.

Lev-Hasharon Medical Center, POB 90000, Netanya 42100, Israel; Sackler Faculty of Medicine, Tel Aviv University, POB 39040, Tel Aviv 69978, Israel. Electronic address:

Background: Though schizophrenia is associated with substantial psychiatric comorbidity, data pertaining to multiple comorbid psychiatric disorders among individuals with schizophrenia is missing. Furthermore, despite abundant research indicating that the course of schizophrenia is characterized by relapses, often leading to psychiatric emergency room visits and consequent hospitalizations, data regarding the association between different comorbid psychiatric diagnoses among schizophrenia patients, and these hospitalization-related factors is lacking. The aim of this study was to describe the number and types of comorbid psychiatric diagnoses of inpatients diagnosed with schizophrenia, and to explore whether these are associated with hospitalization-related factors. Read More

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December 2018

Compartment models for the electrical stimulation of retinal bipolar cells.

PLoS One 2018 17;13(12):e0209123. Epub 2018 Dec 17.

Institute for Analysis and Scientific Computing, Vienna University of Technology, Wiedner Hauptstrasse, Vienna, Austria.

Bipolar cells of the retina are among the smallest neurons of the nervous system. For this reason, compared to other neurons, their delay in signaling is minimal. Additionally, the small bipolar cell surface combined with the low membrane conductance causes very little attenuation in the signal from synaptic input to the terminal. Read More

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December 2018

Nonlinear Indices with Applications to Schizophrenia and Bipolar Disorder.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):17-56

Western University, London, ON, Canada.

In this article we study the application of nonlinear indices (sometimes called complexity indices) to univariate time series data arising from studies of schizophrenia and bipolar disorder. Specifically, we consider time series arising from EEG studies, ECG studies, and self-report mood data. As part of our analysis, we empirically examine the claim in the literature that complexity tends to be higher in the EEG of schizophrenia patients than controls and that this tendency is dampened or even inverted by medication, increasing age, and reduced symptomatology. Read More

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January 2019

Hospitalization risk factors in antipsychotic-treated schizophrenia, bipolar I disorder or major depressive disorder.

J Comp Eff Res 2018 Dec 17. Epub 2018 Dec 17.

Health Economics and Outcomes Research, Lundbeck, 6 Parkway North, Deerfield, IL 60015, USA.

Aim: To examine hospitalization risk factors in antipsychotic-treated patients with schizophrenia, bipolar I disorder (BD-I) or major depressive disorder (MDD).

Patients & Methods: Using Truven Health MarketScan Commercial, Medicaid and Medicare Supplemental data (01/01/2012-06/30/2016), logistic regression models were performed to identify risk factors for both psychiatric and all-cause hospitalization in three separate analyses.

Results: Significant risk factors included prior hospitalization (schizophrenia: odds ratio [95% CI]: 2. Read More

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December 2018

IgG4 Related Disease, A Case of Large Vessel Vasculitis

Ir Med J 2018 Oct 11;111(9):824. Epub 2018 Oct 11.

Rheumatology Department, Cork University Hospital

Aim This report describes a case of large vessel vasculitis highlighting diagnostic and therapeutic challenges. It describes the use of the B cell depleting agent Rituximab in this setting. This is the case of a 50 year old lady with bipolar disorder presenting with lower limb pain. Read More

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October 2018

The Impact of Electrical Charge Delivery on Inhibition of Mechanical Hypersensitivity in Nerve-Injured Rats by Sub-Sensory Threshold Spinal Cord Stimulation.

Neuromodulation 2018 Dec 17. Epub 2018 Dec 17.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

Objectives: Spinal cord stimulation (SCS) represents an important neurostimulation therapy for pain. A new ultra-high frequency (10,000 Hz) SCS paradigm has shown improved pain relief without eliciting paresthesia. We aim to determine whether sub-sensory threshold SCS of lower frequencies also can inhibit mechanical hypersensitivity in nerve-injured rats and examine how electric charge delivery of stimulation may affect pain inhibition by different patterns of subthreshold SCS. Read More

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December 2018

Enrichment of pathogenic variants in genes associated with inborn errors of metabolism in psychiatric populations.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 16. Epub 2018 Dec 16.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Many genetic conditions can mimic mental health disorders, with psychiatric symptoms that are difficult to treat with standard psychotropic medications. This study tests the hypothesis that psychiatric populations are enriched for pathogenic variants associated with selected inborn errors of metabolism (IEMs). Using next-generation sequencing, 2046 psychiatric patients were screened for pathogenic variants in genes associated with four IEMs, Niemann-Pick disease type C (NPC), Wilson disease (WD), homocystinuria (HOM), and acute intermittent porphyria (AIP). Read More

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December 2018

Pre-procedural imaging to guide transcoronary ethanol ablation for refractory septal ventricular tachycardia.

J Cardiovasc Electrophysiol 2018 Dec 16. Epub 2018 Dec 16.

Arrhythmia Unit. Cardiology Service. Hospital Universitari Vall d'Hebron.

Background: Radiofrequency ablation (RF) of ventricular tachycardia (VT) due to intramural foci has a high recurrence rate. Several techniques as bipolar ablation, irrigated needle ablation catheter and retrograde coronary venous ethanol ablation have been suggested. Transarterial coronary ethanol ablation (TCEA) can be also effective. Read More

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December 2018

Momentary giant T-waves hint the genesis of the electrocardiographic T-wave in human.

Authors:
Tomiya Yasumasu

J Arrhythm 2018 Dec 10;34(6):640-642. Epub 2018 Sep 10.

Department of Cardiology Saiseikai Yahata General Hospital Kitakyushu Japan.

T-wave morphology changes are linked to dispersion of ventricular repolarization. I encountered an 80-year-old man on hemodialysis manifesting momentary giant T-waves and QT prolongation on the 12-lead electrocardiogram, soon after initiating mechanical ventilation because of hypercapnic respiratory failure. A computed tomography of the brain showed no acute cerebrovascular accidents. Read More

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December 2018

Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0.

Front Psychiatry 2018 29;9:641. Epub 2018 Nov 29.

Barcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.

Personalized treatment is defined as choosing the "right treatment for the right person at the right time." Although psychiatry has not yet reached this level of precision, we are on the way thanks to recent technological developments that may aid to detect plausible molecular and genetic markers. At the moment there are some models that are contributing to precision psychiatry through the concept of staging. Read More

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November 2018

Development and testing of acoustically-matched hydrogel-based electrodes for simultaneous EMG-ultrasound detection.

Med Eng Phys 2018 Dec 13. Epub 2018 Dec 13.

Laboratory for Engineering of the Neuromuscular System (LISiN), Dipartimento di Elettronica e Telecomunicazioni, Politecnico di Torino, Corso Duca degli Abruzzi, 24, 10129 Torino, Italy.

In this manuscript we describe the development and testing of a bipolar electrode for the simultaneous acquisition of ultrasound (US) images and surface electromyograms (EMGs) from the same muscle region. The developed electrode (bEMG-US) consists of two circular sensing regions (20 mm diameter) with fixed inter-electrode distance (3.5 cm, center-to-center). Read More

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December 2018

Signal transmission at invaginating cone photoreceptor synaptic contacts following deletion of the presynaptic cytomatrix protein Bassoon in mouse retina.

Acta Physiol (Oxf) 2018 Dec 16:e13241. Epub 2018 Dec 16.

Department of Biology, Animal Physiology, FAU Erlangen-Nürnberg, Staudtstr. 5, 91058, Erlangen, Germany.

Aim: A key feature of the mammalian retina is the segregation of visual information in parallel pathways, starting at the photoreceptor terminals. Cone photoreceptors establish synaptic contacts with On bipolar and horizontal cells at invaginating, ribbon-containing synaptic sites, whereas Off bipolar cells form flat, non-ribbon-containing contacts. The cytomatrix protein Bassoon anchors ribbons at the active zone, and its absence induces detachment of ribbons from the active zone. Read More

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December 2018
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Population pharmacokinetic modeling of sustained release lithium in the serum, erythrocytes and urine of patients with bipolar disorder.

Eur J Clin Pharmacol 2018 Dec 15. Epub 2018 Dec 15.

Département de Psychiatrie et de Médecine Addictologique, AP-HP, HUSLS-LRB-FWD, Paris, France.

Purpose: Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of srLi, administered once a day, in adults. Read More

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December 2018
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Predictive factors associated with driving under the influence among Brazilian drug-using drivers.

Accid Anal Prev 2018 Dec 12;123:256-262. Epub 2018 Dec 12.

Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Rua Professor Álvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil.

The incidence of driving under the influence of psychoactive substances (DUI) and its recidivism can be curtailed by the proper identification of specific and predictive characteristics among drug users. In this sense, interpersonal violence (IV), psychiatric comorbidity and impulsivity seem to play an important role in DUI engagement according to previous studies. There are, however, limited data originated from low and middle income countries. Read More

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December 2018
1 Read

On the (Non-)equivalency of monopolar and bipolar settings for deep brain stimulation fMRI studies of Parkinson's disease patients.

J Magn Reson Imaging 2018 Dec 15. Epub 2018 Dec 15.

GE Global Research Center, Bangalore, India.

Background: The majority of Parkinson's disease patients with deep brain stimulation (DBS) use a monopolar configuration, which presents challenges for EEG and MRI studies. The literature reports algorithms to convert monopolar to bipolar settings.

Purpose/hypothesis: To assess brain responses of Parkinson's disease patients implanted with DBS during fMRI studies using their clinical and presumed equivalent settings using a published conversion recipe. Read More

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December 2018

Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder.

Acta Psychiatr Scand 2018 Dec 15. Epub 2018 Dec 15.

Institute of Clinical Medicine, University of Oslo, Norway.

Objective: The relationship between borderline personality disorder (BPD) and bipolar II disorder (BIP-II) is disputed but understudied. Here, we investigated brain glucose metabolism in these patient groups and healthy control subjects (HCs).

Methods: Sixty-five subjects, 22 BPD (19 females); 22 BIP-II (17 females); 21 HC (14 females) were examined using 2-deoxy-2[18F]-fluoro-d-glucose Positron-Emission Tomography (PET) scanning. Read More

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December 2018

Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

Transl Psychiatry 2018 Dec 14;8(1):280. Epub 2018 Dec 14.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent scopolamine has also shown promise as a rapid-acting antidepressant. This study applied genome-wide markers to investigate the role of genetic variants in predicting acute antidepressant response to both agents. Read More

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December 2018

HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.

EBioMedicine 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Background: Epigenetic histone acetylation is a major event controlling cell functions, such as metabolism, differentiation and repair. Here, we aim to determine whether Valproic acid (VPA), a FDA approved inhibitor of histone deacetylation for bipolar disease, could protect heart against myocardial infarction (MI) injury and elucidate key molecular pathways.

Methods: VPA was administrated to MI rats at different time points, onset and after MI injury. Read More

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December 2018
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Comorbidity of Attention Deficit Hyperactivity Disorder and Generalized Anxiety Disorder in children and adolescents.

Psychiatry Res 2018 Dec 31;270:780-785. Epub 2018 Oct 31.

Department of Human Sciences, Roma Tre University, Rome, Italy.

The aim of the study is to explore the impact of Generalized Anxiety Disorder (GAD) comorbidity in children with Attention Deficit Hyperactivity Disorder (ADHD). Six hundred children with ADHD (mean age = 9.12 years), recruited from 2013 to 2017, participated in the study. Read More

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December 2018

Factors predicting re-hospitalization for inpatients with bipolar mania--A naturalistic cohort.

Psychiatry Res 2018 Dec 30;270:749-754. Epub 2018 Oct 30.

Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan. Electronic address:

Patients with bipolar mania often require re-hospitalization, which can be a social-economic burden. This study aimed to investigate the factors affecting time to re-hospitalization for inpatients with acute bipolar mania. In this 6-year naturalistic study we reviewed the charts of inpatients with acute bipolar mania. Read More

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December 2018

Associations between cognitive impairment and quality of life in euthymic bipolar patients.

Psychiatry Res 2018 Nov 26;271:510-515. Epub 2018 Nov 26.

Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Read More

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November 2018
3 Reads

The IRS/PI3K/Akt signaling pathway mediates olanzapine-induced hepatic insulin resistance in male rats.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Endocrinology and Metabolism Group, Sydney Institute of Health Sciences, Sydney Institute of Traditional Chinese Medicine, Sydney, NSW 2000, Australia. Electronic address:

Aims: Chronic treatment with antipsychotics, especially most of atypical ones, leads to development of metabolic abnormalities. Olanzapine is an atypical antipsychotic widely used in the treatment of schizophrenia and bipolar disorder. The mechanisms underlying olanzapine-induced metabolic adverse effects in the liver, however, remain unclear. Read More

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December 2018
2 Reads

A Double-Blind, Randomized, Placebo-Controlled Study of Aspirin and N-Acetylcysteine as Adjunctive Treatments for Bipolar Depression.

J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.

Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.

Objective: Neuroinflammation has been implicated in the pathophysiology of bipolar disorder. Some evidence shows that nonsteroidal anti-inflammatory drugs (NSAIDs) have promising antidepressant effects. The antioxidant N-acetylcysteine (NAC) may enhance the effects of NSAIDs. Read More

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December 2018

Metabolic Syndrome in Dutch Patients With Bipolar Disorder: A Cross-Sectional Study.

Prim Care Companion CNS Disord 2018 Dec 6;20(6). Epub 2018 Dec 6.

Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands.

Objective: To characterize the prevalence of metabolic syndrome (MetS) among Dutch patients with bipolar disorder (BD), identify factors associated with MetS, and estimate the rate of pharmacologic treatment of MetS in this population.

Methods: A cross-sectional analysis of medical records of adult patients (≥ 18 years) with BD receiving psychotropic drug treatment was performed in a Dutch psychiatric outpatient setting. MetS was determined according to National Cholesterol Education Program Adult Treatment Panel III-Adapted (NCEP ATP III-A) criteria. Read More

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December 2018
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Mogens Schou (1918-2005): a scientist, a doctor and a lithium champion.

Bipolar Disord 2018 Dec 14. Epub 2018 Dec 14.

Aalborg University Hospital, Psychiatry, Aalborg, Denmark.

In November this year, we marked the 100th anniversary of the birthday of Mogens Schou, the great Danish clinical and basic scientist and a true giant of lithium research and treatment. Mogens Schou did more than anybody else in the world to establish lithium therapy, and without his assiduousness lithium may well have been forgotten. To commemorate his achievements a special symposium was organized in Copenhagen dedicated to lithium and the life time contributions of Mogens Schou. Read More

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December 2018
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Study Enrollment when "Pre-Consent" is Utilized for a Randomized Trial of Two Treatments for Acute Agitation in the Emergency Department.

Acad Emerg Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Emergency Medicine, University of Arkansas for Medical Sciences, Little Rock, AR.

Background: Acute agitation in the ED represents a danger to both patients and their caregivers. Medication is often needed, and few high-quality randomized trials have evaluated the optimal drugs for this vulnerable population. In the United States, as of 2017, randomized trials of drugs cannot be conducted under Waiver of Consent (46 CFR 45. Read More

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December 2018

Tmem30a deficiency leads to retinal rod bipolar cell degeneration.

J Neurochem 2018 Dec 12. Epub 2018 Dec 12.

Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Phospholipids are asymmetrically distributed across the mammalian plasma membrane, with phosphatidylserine (PS) and phosphatidylethanolamine (PE) concentrated in the cytoplasmic leaflet of the membrane bilayer and phosphatidylcholine in the exoplasmic leaflet. This asymmetric distribution is dependent on a group of P4 ATPases called PS flippases. The proper transport and function of PS flippases require a β-subunit transmembrane protein 30A (TMEM30A). Read More

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December 2018
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Commentary on Simon et al. 2018: "Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (CEQUEL)".

Authors:
Denise Razzouk

Bipolar Disord 2018 Dec 11. Epub 2018 Dec 11.

Centre of Economic Mental Health, Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

Simon et al. conducted a 52-week prospective cost-utility analysis (CUA) of 201 people with bipolar depression to assess the add-on lamotrigine effectiveness and efficacy (CEQUEL study ) in combination with quetiapine. To that end, they compared health gain using the EuroQol 5D- 3L (EQ-5D) between a quetiapine-only and quetiapine plus lamotrigine regimen in a multi-centre randomized control CEQUEL trial conducted in the United Kingdom and Austria with a health and social care perspective. Read More

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December 2018

The Microbiome in Bipolar Depression: A Longitudinal Study of One Pair of Monozygotic Twins.

Bipolar Disord 2018 Dec 9. Epub 2018 Dec 9.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.

The commensal gut microbiota is a dynamic entity that is influenced by a variety of factors. Previous study has reported considerable individual variability in the bacterial content between related and unrelated individuals, which makes it difficult to identify candidate microorganisms for specific diseases. However, findings from monozygotic (MZ) twins have revealed a high degree of similarity in the composition of gut microbiota between twins. Read More

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December 2018

A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder.

Transl Psychiatry 2018 Dec 13;8(1):274. Epub 2018 Dec 13.

Department of Psychiatry, University of Oxford, Oxford, UK.

Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and subjective recall of mood states. However, deriving clinically meaningful information from the complex time series data these technologies present is challenging, and the current implications for patient care are uncertain. Read More

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December 2018
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The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders.

Sci Transl Med 2018 Dec 13. Epub 2018 Dec 13.

Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.

Schizophrenia and bipolar disorder are complex psychiatric diseases with risks contributed by multiple genes. Dysregulation of gene expression has been implicated in these disorders, but little is known about such dysregulation in the human brain. We analyzed three transcriptome datasets from 394 postmortem brain tissue samples from patients with schizophrenia or bipolar disorder or from healthy control individuals without a known history of psychiatric disease. Read More

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December 2018
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Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.

Science 2018 12;362(6420)

Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA.

Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic organization in diseased brains are limited. In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well as controls. Read More

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December 2018
11 Reads

'Did You Get My Text?': Commentary on 'Objective smartphone data as a potential diagnostic marker of bipolar disorder'.

Aust N Z J Psychiatry 2018 Dec 14:4867418815983. Epub 2018 Dec 14.

Child and Adolescent Mood Disorders Program, Division of Child and Adolescent Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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December 2018

Commentary on: Objective smartphone data as a potential diagnostic marker of bipolar disorder.

Authors:
Sophia Frangou

Aust N Z J Psychiatry 2018 Dec 14:4867418814199. Epub 2018 Dec 14.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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December 2018

Structural and metabolic cerebral alterations between elderly bipolar disorder and behavioural variant frontotemporal dementia: A combined MRI-PET study.

Aust N Z J Psychiatry 2018 Dec 13:4867418815976. Epub 2018 Dec 13.

1 Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

Background:: Elderly bipolar disorder (BD) and behavioural variant of frontotemporal dementia (bvFTD) may exhibit similar symptoms and both disorders are characterized by selective abnormalities in cortical and subcortical regions that are associated with cognitive and emotional impairments. We aimed to investigate common and distinct neural substrates of BD and bvFTD by coupling, for the first time, magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques.

Methods:: 3-Tesla MRI and 18 fluorodeoxyglucose-PET scans were acquired for 16 elderly BD patients, 23 bvFTD patients with mild cognitive impairments and 68 healthy controls (48 for PET and 20 for MRI analyses). Read More

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December 2018

Childhood trauma in mood disorders: Neurobiological mechanisms and implications for treatment.

Pharmacol Rep 2018 Oct 11;71(1):112-120. Epub 2018 Oct 11.

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland. Electronic address:

A contemporary model for the pathogenesis of mood disorders (bipolar and depressive disorders) involves gene-environmental interaction, with genetic predisposition, epigenetic regulation, and environmental effects. Among multiple environmental factors, the experience of childhood trauma can be connected with the pathogenesis, course and the treatment of mood disorders. Patients with mood disorders have the greater frequency of childhood trauma compared with the general population, and adverse childhood experiences can exert a negative impact on their clinical course. Read More

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October 2018

Mixed effects approach to the analysis of the stepped wedge cluster randomised trial-Investigating the confounding effect of time through simulation.

PLoS One 2018 13;13(12):e0208876. Epub 2018 Dec 13.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Background: A stepped wedge cluster randomised trial (SWCRT) is a multicentred study which allows an intervention to be rolled out at sites in a random order. Once the intervention is initiated at a site, all participants within that site remain exposed to the intervention for the remainder of the study. The time since the start of the study ("calendar time") may affect outcome measures through underlying time trends or periodicity. Read More

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December 2018

Amyloid Fibrils Length Controls Shape and Structure of Nematic and Cholesteric Tactoids.

ACS Nano 2018 Dec 13. Epub 2018 Dec 13.

Amyloid fibrils offer the possibility of controlling their contour length, aspect ratio and length distribution, without affecting other structural parameters. Here we show that a fine control in the contour length distribution of β-lactoglobulin amyloid fibrils, achieved by mechanical shear stresses of different levels, translates into the organization of tactoids of different shapes and morphologies. While longer fibrils lead to highly elongated nematic tactoids in an isotropic continuous matrix, only sufficiently shortened amyloid fibrils lead to cholesteric droplets. Read More

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December 2018

Options of bipolar muscle transfers to restore deltoid function: an anatomical study.

Surg Radiol Anat 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopedics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose: To outline the technical details and determine the ranges of two pedicled functioning flaps that are the upper pectoralis major (UPM) and latissimus dorsi (LD) to elucidate their respective indications with regards to deltoid impairment.

Methods: The UPM and LD bipolar transfers were performed in 14 paired cadaveric shoulders, one on each side. The UPM was flipped 180° laterally over its pedicle to be placed onto the anterior deltoid. Read More

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December 2018

A miniaturized solid salt reverse electrodialysis battery: a durable and fully ionic power source.

Chem Sci 2018 Nov 27;9(42):8071-8076. Epub 2018 Aug 27.

Department of Chemistry , Seoul National University , Seoul , 08826 , Republic of Korea . Email:

A novel pump-free miniaturized reverse electrodialysis (RED) system was designed to provide lasting power transduced from salinity gradients, named solid salt RED (ssRED), and this quasi-battery uses a solid salt instead of electrolyte solution for streamlined usage. It is portable, flexible, comparable in size to a universal serial bus flash drive, and easily activated with a small amount of water. It maintains a constant ionic concentration gradient through precipitation reactions between a pair of different salts. Read More

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November 2018

Memory Impairment and Plasma BDNF Correlates of the Polymorphism in Patients With Bipolar II Disorder.

Front Genet 2018 27;9:583. Epub 2018 Nov 27.

Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Studies suggest that a functional polymorphism of brain-derived neurotrophic factor (BDNF), polymorphism affects cognitive functions, however, the effect is unclear in bipolar II (BD-II) disorder. We used the Wechsler Memory Scale-third edition (WMS-III), the presence of the polymorphism, and plasma concentrations of BDNF to investigate the association between memory impairment and BDNF in BD-II disorder. We assessed the memory functions of 228 BD-II patients and 135 healthy controls (HCs). Read More

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November 2018

Effect of Betahistine and Metformin on Antipsychotic-Induced Weight Gain: An Analysis of Two Clinical Trials.

Front Psychiatry 2018 27;9:620. Epub 2018 Nov 27.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China.

Antipsychotic-induced weight gain is one of the most common adverse effects of antipsychotic treatment. However, there are no well-established interventions for the weight gain yet. In this study, we pooled the data from two clinical trials, which were originally examining the efficacy of betahistine and the efficacy of metformin in treating antipsychotic-induced weight gain and insulin resistance. Read More

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November 2018

Insulin/high-density lipoprotein cholesterol ratio: A newly-discovered predictor of esophageal varices in patients with hepatitis C virus-related cirrhosis in the absence of diabetes mellitus.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Department Clinical Pathology, Al-Azhar University School of Medicine, New Damietta, Damietta, Egypt.

Background/aims: Insulin resistance (IR) is closely linked with chronic hepatitis C virus (HCV) and its complications, particularly hepatic fibrosis. The aim of the present study was to investigate some biochemical markers that are potentially related to IR as predictors of esophageal varices (EV) in patients with compensated HCV cirrhosis who do not have diabetes or metabolic syndrome.

Materials And Methods: One hundred subjects without diabetes with compensated HCV-related cirrhosis who did not fulfill the diagnostic criteria of metabolic syndrome were subjected to clinical, laboratory, ultrasonographic, and endoscopic assessments. Read More

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December 2018

Decoration of Dibenzofuran Using Cyanocarbazole via 6- Position As a Molecular Design Approach for High Triplet Energy Bipolar Host Materials.

Chem Asian J 2018 Dec 7. Epub 2018 Dec 7.

Sungkyunkwan University, Polymer science and engineering, 2066, Seobu-ro, Jangan-gu, 440-746, Suwon, KOREA, REPUBLIC OF.

In this study, two new dibenzofuran derivatives featuring one or two cyanocarbazole units, 6-(dibenzo[b,d]furan-4-yl)-9-phenyl-9H-carbazole-3-carbonitrile (mBFCzCN) and 6,6'-(dibenzo[b,d]furan-4,6-diyl)bis(9-phenyl-9H-carbazole-3-carbonitrile) (dBFCzCN), were developed as host materials for phosphorescent organic light emitting diodes (PhOLEDs). A new molecular design connecting the cyanocarbazole to the dibenzofuran using the cyanocarbazole 6-position instead of its 9-position was created, and the effects of number of cyanocarbazole units in the dibenzofuran building block on the photophysical and electroluminescence properties were investigated in detail. The mBFCzCN compound revealed high triplet energy (2. Read More

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December 2018

Zerumbone, a cyclic sesquiterpene, exerts antimitotic activity in HeLa cells through tubulin binding and exhibits synergistic activity with vinblastine and paclitaxel.

Cell Prolif 2018 Dec 7:e12558. Epub 2018 Dec 7.

School of Biotechnology, National Institute of Technology Calicut, Calicut, Kerala, India.

Objectives: The aim of this study was to elucidate the antimitotic mechanism of zerumbone and to investigate its effect on the HeLa cells in combination with other mitotic blockers.

Materials And Methods: HeLa cells and fluorescence microscopy were used to analyse the effect of zerumbone on cancer cell lines. Cellular internalization of zerumbone was investigated using FITC-labelled zerumbone. Read More

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December 2018

Loss of Ca/Calmodulin Dependent Protein Kinase Kinase 2 Leads to Aberrant Transferrin Phosphorylation and Trafficking: A Potential Biomarker for Alzheimer's Disease.

Front Mol Biosci 2018 20;5:99. Epub 2018 Nov 20.

Division of Neurodegenerative Disorders, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada.

Ca/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a serine/threonine kinase that is activated following an increase in the intracellular Ca concentration and activates multiple signaling cascades that control physiologically important neuronal processes. CaMKK2 has been implicated in schizophrenia, bipolar disease, neurodegeneration, and cancer. Using isoelectric focusing (IEF) and mass spectrometry-based proteomic analysis, it was found that knockdown (KD) of CaMKK2 in cultured adult primary dorsal root ganglion (DRG) neurons resulted in the reduction of transferrin (TF) phosphorylation at multiple functionally relevant residues which corresponded to loss of an acidic fraction (pH~3-4) of TF. Read More

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November 2018

Medication nonadherence in bipolar disorder: a narrative review.

Ther Adv Psychopharmacol 2018 Dec 16;8(12):349-363. Epub 2018 Oct 16.

Academic Psychiatry, Wolfson Research Centre, Campus for Ageing and Vitality, Northern Centre for Mood Disorders and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.

A number of effective maintenance medication options exist for bipolar disorder (BD) and these are regarded as the foundation of long-term treatment in BD. However, nonadherence to medication is common in BD. For example, a large data base study in the United States of America (USA) showed that approximately half of patients with BD were nonadherent with lithium and maintenance medications over a 12 month period. Read More

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December 2018

Anti-cytokine agents for anhedonia: targeting inflammation and the immune system to treat dimensional disturbances in depression.

Ther Adv Psychopharmacol 2018 Dec 19;8(12):337-348. Epub 2018 Nov 19.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada Brain and Cognition Discovery Foundation, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Psychiatry, University of Toronto, Toronto, ON, Canada Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

The etiology of mood disorders is mechanistically heterogeneous, underscoring the need for a dimensional approach to identify and develop targeted treatments in psychiatry. Accumulating evidence implicates inflammation as an important contributor to the pathophysiology of depression and presents the immune system as a viable therapeutic target that may be more proximate to the pathogenic nexus of brain-based disorders in specific subpopulations. Anhedonia is a transdiagnostic (e. Read More

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December 2018
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Baclofen Response in Alcohol Dependent Patients Concurrently Receiving Antidepressants: Secondary Analysis From the BacALD Study.

Front Psychiatry 2018 19;9:576. Epub 2018 Nov 19.

NHMRC Centre of Research Excellence in Mental Health and Substance Use, Central Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

There is little information with regards to the efficacy of baclofen among alcohol patients concurrently receiving antidepressants (AD). The present study aimed to conduct a secondary analysis of the moderating role of antidepressants in the BacALD trial which evaluated the efficacy of baclofen to reduce alcohol consumption in alcohol dependent patients. Alcohol dependent patients ( = 104) were treated for 12 weeks with 30 mg/day of baclofen (21 = AD and 15 = no AD), 75 mg baclofen (19 = AD and 16 = no AD) or placebo (17 = AD and 16 = no AD). Read More

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November 2018