49,286 results match your criteria Bipolar Affective Disorder


Seasonality Patterns of Internet Searches on Mental Health: Exploratory Infodemiology Study.

JMIR Ment Health 2019 Apr 24;6(4):e12974. Epub 2019 Apr 24.

Anxiety Treatment and Research Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Background: The study of seasonal patterns of public interest in psychiatric disorders has important theoretical and practical implications for service planning and delivery. The recent explosion of internet searches suggests that mining search databases yields unique information on public interest in mental health disorders, which is a significantly more affordable approach than population health studies.

Objective: This study aimed to investigate seasonal patterns of internet mental health queries in Ontario, Canada. Read More

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http://dx.doi.org/10.2196/12974DOI Listing

Stepwise treatment of acute bipolar depression.

Bipolar Disord 2019 Apr 23. Epub 2019 Apr 23.

Treatment Algorithm Group.

One of the most controversial mood disorder management topics is how to manage bipolar depression, as evidenced by varying guidelines and, in particular, whether antidepressants should be prescribed. In relation to the latter, the first issue is that of efficacy while the second issue is their potential 'cost' in that they may induce switching (into a hypo/manic state) or the induction of a mixed state and/or also worsen the long-term pattern of the disorder. Both issues are worthy of consideration before generating a framework of recommended treatment model. Read More

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http://dx.doi.org/10.1111/bdi.12780DOI Listing

A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 20. Epub 2019 Apr 20.

Bipolar Disorder Program (PROMAN), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.

Mental disorders are highly prevalent and important causes of medical burden worldwide. Co-occurrence of neurological and psychiatric symptoms are observed among mental disorders, representing a challenge for their differential diagnosis. Psychiatrists and neurologists have faced challenges in diagnosing old adults presenting behavioral changes. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.04.008DOI Listing

Hospital Stay in Synthetic Cannabinoid Users With Bipolar Disorder, Schizophrenia, or Other Psychotic Disorders Compared With Cannabis Users.

J Stud Alcohol Drugs 2019 Mar;80(2):230-235

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas.

Objective: The use of synthetic cannabinoid (SC) products has become popular in recent years, but data regarding their impact on hospital stays are limited. The impact of SC and cannabis use on hospital length of stay and doses of antipsychotics at discharge was assessed in this study.

Method: The sample consisted of inpatients with discharge diagnoses of bipolar disorder, schizophrenia, or other psychotic disorders. Read More

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Predicting psychosis-spectrum diagnoses in adulthood from social behaviors and neighborhood contexts in childhood.

Dev Psychopathol 2019 Apr 24:1-15. Epub 2019 Apr 24.

Centre for Research in Human Development and Department of Psychology,Concordia University,Montréal,Québec,Canada.

Research showing that risk for schizophrenia, bipolar disorder with psychosis, and other psychosis-spectrum diagnoses in adulthood is multidetermined has underscored the necessity of studying the additive and interactive factors in childhood that precede and predict future disorders. In this study, risk for the development of psychosis-spectrum disorders was examined in a 2-generation, 30-year prospective longitudinal study of 3,905 urban families against a sociocultural backdrop of changing economic and social conditions. Peer nominations of aggression, withdrawal, and likeability and national census information on neighborhood-level socioeconomic disadvantage in childhood, as well as changes in neighborhood socioeconomic conditions over the lifespan, were examined as predictors of diagnoses of schizophrenia, bipolar disorder, and other psychosis-spectrum disorders in adulthood relative to developing only nonpsychotic disorders or no psychiatric disorders. Read More

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http://dx.doi.org/10.1017/S095457941900021XDOI Listing

Response to the article entitled 'Mood stabilisers and risk of stroke in bipolar disorder'.

Br J Psychiatry 2019 May;214(5):305

Associate Professor,All India Institute of Medical Sciences,India.

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http://dx.doi.org/10.1192/bjp.2019.63DOI Listing

Retinal vascular abnormalities in schizophrenia and bipolar disorder: A window to the brain.

Bipolar Disord 2019 Apr 22. Epub 2019 Apr 22.

Dept. of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.

Objectives: The examination of retinal microvascular abnormalities through fundus photography is currently the best available non-invasive technique for assessment of cerebral vascular status. Several studies in the last decade have reported higher incidences of adverse cerebrovascular events in Schizophrenia (SCZ) and bipolar disorder (BD). However, retinal microvasculature abnormalities in SCZ and BD have remained under-explored, and no study has compared this aspect of SCZ and BD till date. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bdi.12779
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http://dx.doi.org/10.1111/bdi.12779DOI Listing
April 2019
1 Read

Mental Health Apps in Psychiatric Treatment: A Patient Perspective on Real World Technology Usage.

JMIR Ment Health 2019 Apr 22;6(4):e12292. Epub 2019 Apr 22.

Wistia, Cambridge, MA, United States.

For many people who use mobile apps, the primary motivations are entertainment, news, gaming, social connections, or productivity. For those experiencing health problems, particularly those with chronic conditions such as psychiatric disorders, the stakes are much higher. The digital tools that they select may be the difference between improvement and decompensation or even life and death. Read More

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http://dx.doi.org/10.2196/12292DOI Listing

Lithium treatment, nephrogenic diabetes insipidus and the risk of hypernatraemia: a retrospective cohort study.

Ther Adv Psychopharmacol 2019 4;9:2045125319836563. Epub 2019 Apr 4.

Department of Clinical Sciences, Division of Psychiatry, Sunderby Research Unit, Umeå University, Umeå, Sweden.

Background: Hypernatraemia is a serious condition that can potentially become life threatening. It is known that lithium is associated with polyuria and nephrogenic diabetes insipidus, risk factors for hypernatraemia. In this study, we tested the hypothesis that lithium treatment was a risk factor for hypernatraemia. Read More

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http://dx.doi.org/10.1177/2045125319836563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457074PMC
April 2019
1 Read

[Clinical features of depressive episode with onset in adolescence and the risk of bipolar depression].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1. Vyp. 2):22-27

Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.

Aim: To study clinical features of depressive episode with the onset in late adolescence associated with the risk of bipolar affective disorder (BAD).

Material And Methods: Forty patients with BAD (ICD-10 F31), who experienced depressive state at the age of 15-18 years corresponding to the diagnostic criteria of 'Depressive episode' (F32), were examined. The duration of follow-up was from 3 to 5 years. Read More

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http://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhi
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http://dx.doi.org/10.17116/jnevro20191191222DOI Listing
January 2019
3 Reads

Temperament and character influence on depression treatment outcome.

J Affect Disord 2019 Apr 9;252:464-474. Epub 2019 Apr 9.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy. Electronic address:

Background: personality features have been repeatedly associated with depression treatment outcome in Major Depressive Disorder (MDD), however conclusive results are still lacking. Moreover, as for Bipolar Disorder (BD), results are only few and preliminary.

Aim: the aim of the present study was to perform an exploratory investigation of the influence of personality traits as assessed by the Temperament and Character Inventory (TCI), on principal depression treatment outcomes (non remission, non response and resistance). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183178
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http://dx.doi.org/10.1016/j.jad.2019.04.031DOI Listing
April 2019
2 Reads

Obstetric complications in bipolar disorder: The role of mental health disorders in the risk of caesarean section.

J Affect Disord 2019 Apr 8;252:458-463. Epub 2019 Apr 8.

Perinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clinic, IDIBAPS, Barcelona, Catalonia, Spain; Vulnerability, Psychopathology and Gender research group, Generalitat de Catalunya, Catalonia, Spain.

Background: Women with Bipolar Disorder (BD) during pregnancy present a negative impact on them and their babies' health. Caesarean Section (C-Section) is an intervention to reduce complications associated with childbirth, but it also has risks, including maternal infections, anaesthetic and psychological complications. There are few studies that analyse the C-Section rates in women with BD compared to the general population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183226
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http://dx.doi.org/10.1016/j.jad.2019.04.017DOI Listing
April 2019
2 Reads

Agitated depression in bipolar disorder.

Bipolar Disord 2019 Apr 20. Epub 2019 Apr 20.

Psychological Medicine, University of Worcester, UK.

Objectives: It has been suggested that agitated depression (AD) is a common, severe feature in bipolar disorder. We aimed to estimate the prevalence of AD and investigate whether presence of AD was associated with episodic and lifetime clinical features in a large well-characterised bipolar disorder sample.

Method: The prevalence of agitation, based on semi-structured interview and medical case-notes, in the most severe depressive episode was estimated in 2925 individuals with DSM-IV bipolar disorder recruited into the UK Bipolar Disorder Research Network. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bdi.12778
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http://dx.doi.org/10.1111/bdi.12778DOI Listing
April 2019
1 Read

Food insecurity and work impairment in people with severe mental disorders in a rural district of Ethiopia: a cross-sectional survey.

Soc Psychiatry Psychiatr Epidemiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Purpose: In this study, we aimed to identify factors associated with severe food insecurity and work impairment in people with severe mental disorders (SMD) in a rural African setting, with a view to identifying potential areas for intervention.

Methods: A community-based, cross-sectional survey was conducted in Sodo district, south central Ethiopia. Key informant-identified people with possible SMD were referred for assessment by trained primary care workers and received confirmatory psychiatric diagnoses from psychiatric nurses using a standardized clinical interview. Read More

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http://link.springer.com/10.1007/s00127-019-01709-7
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http://dx.doi.org/10.1007/s00127-019-01709-7DOI Listing
April 2019
1 Read

Psychiatric Disorders and Alcohol Consumption Among Low-Income African Americans:Gender Differences.

Brain Sci 2019 Apr 18;9(4). Epub 2019 Apr 18.

Department of Family Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

Background: Although cooccurrence of nonsubstance use disorders (non-SUDs) and substance use is well-established in the literature, most of what we know in this regard is derived from studies that have recruited predominantly White sample populations. As a result, there is a gap in knowledge on this link among low-income African Americans (AAs). There is also a need to understand how low-income AA men and women differ in these associations. Read More

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http://dx.doi.org/10.3390/brainsci9040086DOI Listing

Clinical Characteristics of Obstructive Sleep Apnea in Psychiatric Disease.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Patients with serious psychiatric diseases (major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia and psychotic disorder) often complain about sleepiness during the day, fatigue, low energy, concentration problems, and insomnia; unfortunately, many of these symptoms are also frequent in patients with Obstructive Sleep Apnea (OSA). However, existing data about the clinical appearance of OSA in Psychiatric Disease are generally missing. The aim of our study was a detailed and focused evaluation of OSA in Psychiatric Disease, in terms of symptoms, comorbidities, clinical characteristics, daytime respiratory function, and overnight polysomnography data. Read More

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https://www.mdpi.com/2077-0383/8/4/534
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http://dx.doi.org/10.3390/jcm8040534DOI Listing
April 2019
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Temperament correlates in adult ADHD: A systematic review.

J Affect Disord 2019 Apr 8;252:394-403. Epub 2019 Apr 8.

Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy. Electronic address:

Background: Attention deficit and hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in children, but adult-ADHD is still an under-diagnosed and untreated condition. Treating adult-ADHD is complex and requires effective strategies for ADHD symptoms and comorbidities. Because of its high comorbidity rate with mood disorders and the growing interest in symptoms of emotional dysregulation in these patients, our aim was to collect studies that investigated temperament correlates in adult people with ADHD, to better understand the association between them and the eventual role of temperament as a prognostic-therapeutic marker. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183303
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http://dx.doi.org/10.1016/j.jad.2019.04.006DOI Listing
April 2019
2 Reads

Schizophrenia and Bipolar Illness in the Relatives of University Scientists: An Epidemiological Report on the Creativity-Psychopathology Relationship.

Front Psychiatry 2019 2;10:175. Epub 2019 Apr 2.

Mental Health Center Amager, Copenhagen, Denmark.

A potential link between creativity and mental illness has been a longstanding topic for human studies and empirical research. The major problem is defining creativity and establishing its measurable indicators. A few high-quality epidemiological studies have been undertaken and point to a link between creativity and vulnerability to mental illness. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454109PMC

Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.

Am J Geriatr Psychiatry 2019 Mar 6. Epub 2019 Mar 6.

McLean Hospital Division of Geriatric Psychiatry (EJM, DGH, BPF), Belmont, MA; Department of Psychiatry (DGH, CR, EJ, MS, BPF), Harvard Medical School, Boston. Electronic address:

Objective: This study compared brain energy metabolism, as measured by cerebral concentrations of glutamate (Glu), glutamine (Gln), and N-acetyl aspartate (NAA), in older age bipolar depression (OABD) to that of psychiatrically healthy comparison subjects using proton (H) magnetic resonance spectroscopy imaging at 4-Tesla. Metabolite levels were assessed in OABD subjects before and after 8 weeks of lamotrigine therapy with the goal of determining relationships between cerebral energy metabolism, depression symptom severity, and changes in depression symptom response.

Methods: Individuals (n = 21, mean age: 62. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10647481193027
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http://dx.doi.org/10.1016/j.jagp.2019.02.017DOI Listing
March 2019
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Meningioma and psychiatric symptoms: An individual patient data analysis.

Asian J Psychiatr 2019 Mar 28;42:94-103. Epub 2019 Mar 28.

Department of Psychiatry, Dr Ram Manohar Lohia Hospital PGIMER, New Delhi, India.

Meningioma is a slow-growing benign tumor arising from meninges and is usually asymptomatic. Though neuropsychiatric symptoms are common in patients with brain tumors, they often can be the only manifestation in cases of meningioma. Meningiomas might present with mood symptoms, psychosis, memory disturbances, personality changes, anxiety, or anorexia nervosa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18762018183113
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http://dx.doi.org/10.1016/j.ajp.2019.03.029DOI Listing
March 2019
3 Reads

The effect of adjunctive nutraceuticals in bipolar disorder: A systematic review of randomized placebo-controlled trials.

J Affect Disord 2019 Apr 8;252:334-349. Epub 2019 Apr 8.

Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Italy; U.O.C. Clinica Psichiatrica, A.O.U. Policlinico-Vittorio Emanuele, Presidio "G. Rodolico", Catania, Italy.

Background: Nutraceuticals are a group of compounds of growing interest for mental health professionals. Given the implication of certain nutrients in the onset of bipolar disorder, it has been hypothesized that nutraceuticals might be effective in improving symptoms of the condition (i.e. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.039DOI Listing
April 2019
1 Read

The unmasking of hidden severe hyponatremia after long-term combination therapy in exacerbated bipolar patients: a case series.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy.

Hyponatremia is occasionally unmasked in psychiatric patients during hospitalization after routine blood and urinary tests, and correlates in most cases with an inappropriate secretion of antidiuretic hormone, mainly due to iatrogenic factors. Only a few studies have regarded the combination of psychotropic drugs as triggers of chronic, asymptomatic hyponatremia in bipolar patients, who require to be hospitalized because of the exacerbation of their mental illness. We presented three clinical cases of patients affected by a long-term psychiatric disorder and under polypharmacotherapy for several months. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000265DOI Listing
April 2019
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The Delayed Diagnosis of Thyroid Storm in Patients with Psychosis: A Report of Two Cases.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Japan.

We herein report two cases of patients with thyroid storm with a delayed diagnosis due to psychosis. The patients were a 63-year-old woman with bipolar II disorder and a 37-year-old man with major depressive disorder. The psychoses in both patients were well controlled with medication. Read More

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http://dx.doi.org/10.2169/internalmedicine.2681-19DOI Listing
April 2019
1 Read

Arnold-Chiari Type I Manifesting as Bipolar Disorder.

Prim Care Companion CNS Disord 2019 Apr 11;21(2). Epub 2019 Apr 11.

Department of Psychiatry, New York Medical College, New York, New York, USA.

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http://www.psychiatrist.com/PCC/article/Pages/2019/v21n02/18
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http://dx.doi.org/10.4088/PCC.18l02368DOI Listing
April 2019
2 Reads

Oral Ketamine for Depression: A Systematic Review.

J Clin Psychiatry 2019 Apr 16;80(3). Epub 2019 Apr 16.

Mood Disorder Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: Intravenous (IV) ketamine has rapid and robust antidepressant effects; however, poor accessibility of the IV route often limits its use. Numerous alternative routes of administration are being investigated. Oral ketamine is particularly appealing for its ease of use with the potential for high accessibility. Read More

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http://dx.doi.org/10.4088/JCP.18r12475DOI Listing
April 2019
6 Reads

Association of Rare Copy Number Variants With Risk of Depression.

JAMA Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, United Kingdom.

Importance: The role of large, rare copy number variants (CNVs) in neuropsychiatric disorders is well established, but their association with common psychiatric disorders, such as depression, remains unclear.

Objective: To examine the association of a group of 53 CNVs associated with neurodevelopmental disorders and burden of rare CNVs with risk of depression.

Design, Setting, And Participants: This case-control study used data from the UK Biobank study sample, which comprised 502 534 individuals living in the United Kingdom. Read More

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http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapsychiatry.2019.0566DOI Listing
April 2019
3 Reads

Increased levels of plasma IL-1b and BDNF can predict resistant depression patients.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):361-369. Epub 2019 Apr 11.

Dante Pazzanese Institute of Cardiology, São Paulo, SP, Brasil.

Background: There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result in Coronary Artery Disease occurrence.

Objective: This study aimed to compare the subclinical atherosclerosis markers, inflammatory profile, and BDNF production in Resistant Depression (RD) or Bipolar Affective Disorder (BAD) patients under conventional treatment.

Methods: The population evaluated was comprised of 34 RD, 43 BAD, and 41 controls. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.361DOI Listing
March 2019
2 Reads

Barriers and facilitators perceived by people with bipolar disorder for the practice of exercise: a qualitative study.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):1-8. Epub 2019 Apr 1.

Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Introduction: Exercising regularly has benefits for people with bipolar disorder. Nevertheless, as a group, these patients tend to be less physically active than the general population and little is known from the viewpoint of the patients about the barriers and facilitators to such a practice.

Objective: To know the barriers and facilitators perceived by people with bipolar disorder for the practice of exercise. Read More

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http://dx.doi.org/10.1590/2237-6089-2017-0069DOI Listing
April 2019
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Mood Prediction of Patients With Mood Disorders by Machine Learning Using Passive Digital Phenotypes Based on the Circadian Rhythm: Prospective Observational Cohort Study.

J Med Internet Res 2019 Apr 17;21(4):e11029. Epub 2019 Apr 17.

Korea University College of Medicine, Department of Psychiatry, Seoul, Republic of Korea.

Background: Virtually, all organisms on Earth have their own circadian rhythm, and humans are no exception. Circadian rhythms are associated with various human states, especially mood disorders, and disturbance of the circadian rhythm is known to be very closely related. Attempts have also been made to derive clinical implications associated with mood disorders using the vast amounts of digital log that is acquired by digital technologies develop and using computational analysis techniques. Read More

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http://dx.doi.org/10.2196/11029DOI Listing
April 2019
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Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia.

Psychol Med 2019 Apr 17:1-12. Epub 2019 Apr 17.

Division of Adult Psychiatry,Department of Psychiatry,Geneva University Hospitals,Chemin du Petit-Bel-Air,1225 Chêne-Bourg,Switzerland.

Background: Bipolar disorder I (BD-I) is defined by episodes of mania, depression and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood. Read More

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http://dx.doi.org/10.1017/S0033291719000801DOI Listing
April 2019
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Roles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorder.

Indian J Psychiatry 2019 Mar-Apr;61(2):161-166

Department of Psychiatry, Aydın Government Hospital, Aydin, Turkey.

Background: The C677T and A1298C mutations of 5,10-methylenetetrahydrofolate reductase (MTHFR) have been linked with conditions such as depression, bipolar disorder, and schizophrenia, but there are not clear the relationship between MTHFR polymorphisms and obsessive-compulsive disorder (OCD).

Aim: The current study was planned to investigate the link between the MTHFR polymorphisms and OCD in patients to reveal any potential correlations that may be used as a novel marker in diagnosis of people who are in high-risk group of developing OCD.

Materials And Methods: Blood samples from 64 highly characterized symptomatic cases and 64 gender- and age-matched control participants were analyzed for MTHFR C677T and A1298C gene variants. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_370_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425796PMC
April 2019
1 Read

Impulsivity differences between bipolar and unipolar depression.

Indian J Psychiatry 2019 Mar-Apr;61(2):156-160

Department of Psychiatry, Faculty of Medicine, Sakarya University, Sakarya, Turkey.

Background: Even though particularly bipolar depression and unipolar depression seem to be similar, they show differences in terms of the etiology, phenomenology, course, and treatment process. Bipolar depression is associated with mood lability, motor retardation, and hypersomnia to a larger extent. Early age of onset, a high frequency of depressive episodes, and history of bipolar disease in the family are suggestive of bipolar disorder (BD) rather than major depression. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_166_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425788PMC
April 2019
1 Read

Outcomes of Psychoeducation and a Text Messaging Adherence Intervention Among Individuals With Hypertension and Bipolar Disorder.

Psychiatr Serv 2019 Apr 17:appips201800482. Epub 2019 Apr 17.

Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland (Levin, Sajatovic, Rahman, Aebi, Cassidy, Blixen, Klein, Fuentes-Casiano); Neurological and Behavioral Outcomes Center (Levin, Sajatovic, Tatsuoka, Blixen) and Department of Medicine (Rahman), University Hospitals Cleveland Medical Center, Cleveland; Department of Psychiatry, University of California, San Diego, La Jolla (Depp, Cushman, Johnston, Moore); Department of Psychology, Cleveland State University, Cleveland (Eskew).

Objective: This study evaluated the feasibility, acceptability, and preliminary efficacy of psychoeducation plus an automated text messaging intervention (Individualized Texting for Adherence Building-Cardiovascular [iTAB-CV]) to improve adherence to antihypertensives and bipolar disorder medication.

Methods: After a psychoeducation program, iTAB-CV was administered for 2 months. In month 1, participants received one educational-motivational and one mood rating text daily. Read More

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https://psychiatryonline.org/doi/10.1176/appi.ps.201800482
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http://dx.doi.org/10.1176/appi.ps.201800482DOI Listing
April 2019
2 Reads

The brief assessment of cognition in affective disorders: Normative data for the Italian population.

J Affect Disord 2019 Apr 8;252:245-252. Epub 2019 Apr 8.

Department of Neurosciences and Mental Health, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; Department of Psychiatry and Behavioural Sciences, University of Texas at Houston, USA. Electronic address:

Background: To date there are no validated tests in Italian to assess cognitive functions in Bipolar Disorder. Therefore, this study aimed to provide normative data for the Italian version of the Brief Assessment of Cognition in Affective Disorders (BAC-A), a battery targeting neuro- and affective-cognition in affective disorders.

Methods: Data were collected from 228 healthy participants (age range: 18-67; mean age: 34. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.063DOI Listing
April 2019
1 Read

Comorbidity in social anxiety disorder: diagnostic and therapeutic challenges.

Drugs Context 2019 2;8:212573. Epub 2019 Apr 2.

Department of Psychiatry, Istanbul Medical School, Istanbul University, Istanbul, Turkey.

Comorbid disorders are highly prevalent in patients with social anxiety disorder, occurring in as many as 90% of patients. The presence of comorbidity may affect the course of the disease in several ways such as comorbidity in patients with social anxiety disorder (SAD) is related to earlier treatment-seeking behavior, increased symptom severity, treatment resistance and decreased functioning. Moreover, comorbidities cause significant difficulties in nosology and diagnosis, and may cause treatment challenges. Read More

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http://dx.doi.org/10.7573/dic.212573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448478PMC
April 2019
1 Read

Immunoneuropsychiatry - novel perspectives on brain disorders.

Nat Rev Neurol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune responses that involve both innate and adaptive immunity. Autoimmunity, chronic inflammation, infection and psychosocial stress can tip the scales towards disruption of higher-order networks. Read More

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http://www.nature.com/articles/s41582-019-0174-4
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http://dx.doi.org/10.1038/s41582-019-0174-4DOI Listing
April 2019
12 Reads

Functional connectomics of affective and psychotic pathology.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA 02478;

Converging evidence indicates that groups of patients with nominally distinct psychiatric diagnoses are not separated by sharp or discontinuous neurobiological boundaries. In healthy populations, individual differences in behavior are reflected in variability across the collective set of functional brain connections (functional connectome). These data suggest that the spectra of transdiagnostic symptom profiles observed in psychiatric patients may map onto detectable patterns of network function. Read More

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http://dx.doi.org/10.1073/pnas.1820780116DOI Listing
April 2019
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Investigating the jumping to conclusion bias in bipolar disorder.

Cogn Neuropsychiatry 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Psychiatry Department , Ankara Yıldırım Beyazıt University , Ankara , Turkey.

Introduction: Hemsley and Garety described the "jumping to conclusions bias" in which patients with delusions may reach unreasonable results with insufficient information. In this study patients with bipolar disorder and healthy volunteers were compared in terms of jumping to conclusions bias using the beads in the jar task.

Methods: 37 patients with DSM-5 diagnosis of bipolar disorder and 30 healthy controls were tested with the Beads Task (BT), Tower of London Test (ToL) and Barrat Impulsiveness Scale (BIS). Read More

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http://dx.doi.org/10.1080/13546805.2019.1606708DOI Listing
April 2019
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Comparison of 71 bipolar disorder pharmacotherapies for kidney disorder risk: The potential hazards of polypharmacy.

J Affect Disord 2019 Apr 8;252:201-211. Epub 2019 Apr 8.

Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Internal Medicine, Division of Translational Informatics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address:

Background: This study compared the largest set of bipolar disorder pharmacotherapies to date (71 drugs and drug combinations) for risk of kidney disorders (KDs).

Methods: This retrospective observational study used the IBM MarketScan® database to analyze data on 591,052 adults with bipolar disorder without prior nephropathy, for onset of KDs (of "moderate" or "high" severity) following psychopharmacotherapy (lithium, mood stabilizing anticonvulsants [MSAs], antipsychotics, antidepressants), or "No drug". Cox regression models included fixed pre-treatment covariates and time-varying drug exposure covariates to estimate the hazard ratio (HR) of each treatment versus "No drug". Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.009DOI Listing
April 2019
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Low working memory capacity in euthymic bipolar I disorder: No relation to reappraisal on emotion regulation.

J Affect Disord 2019 Apr 8;252:174-181. Epub 2019 Apr 8.

Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Emotion regulation (ER) applies behavioral and cognitive strategies to modify the appearance and intensity of emotions. Working memory capacity (WMC) plays an important role in the ER process, particularly through its influence on the efficiency of ER strategies.

Methods: We investigated interactions between WMC and three ER strategies, namely cognitive reappraisal, expressive suppression, and rumination, in 43 euthymic patients with bipolar I disorder and 48 healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.042DOI Listing
April 2019
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Supporting Self-Management in Bipolar Disorder: Mixed-Methods Knowledge Translation Study.

JMIR Ment Health 2019 04 15;6(4):e13493. Epub 2019 Apr 15.

Centre for Mental Health, Swinburne University of Technology, Melbourne, Australia.

Background: Self-management is increasingly recognized as an important method through which individuals with bipolar disorder (BD) may cope with symptoms and improve quality of life. Digital health technologies have strong potential as a method to support the application of evidence-informed self-management strategies in BD. Little is known, however, about how to most effectively maximize user engagement with digital platforms. Read More

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http://mental.jmir.org/2019/4/e13493/
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http://dx.doi.org/10.2196/13493DOI Listing
April 2019
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Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.

Genes Brain Behav 2019 Apr 15:e12570. Epub 2019 Apr 15.

Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, North Carolina.

Genome-wide association studies linked diacylglycerol kinase eta (DGKH) and iota (DGKI) to mood disorders, including bipolar disorder and schizophrenia, and both genes are expressed throughout the brain. Here, we generated and behaviorally characterized female mice lacking Dgkh alone, Dgki alone, and double Dgkh/Dgki knockout (dKO) mice. We found that fewer than 30% of newborn pups raised by dKO females survived to weaning, while over 85% of pups survive to weaning when raised by wild type (WT) females. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gbb.12570
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http://dx.doi.org/10.1111/gbb.12570DOI Listing
April 2019
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Comments on "Stressful Life Events and Relapse in Bipolar Affective Disorder".

Indian J Psychol Med 2019 Mar-Apr;41(2):199-200

Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

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http://www.ijpm.info/text.asp?2019/41/2/199/253374
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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_42_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436407PMC
April 2019
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'From my point of view, my wife has recovered': A qualitative investigation of caregivers' perceptions of recovery and peer support services for people with bipolar disorder in a Chinese community.

Int J Soc Psychiatry 2019 Apr 15:20764019842287. Epub 2019 Apr 15.

3 Yale Program for Recovery and Community Health, Yale School of Medicine, Yale University, New Haven, CT, USA.

Background: Bipolar disorder (BD) is a chronic mental disorder, and family members play a key role in taking care of the affected individuals. The recovery movement has gradually transformed mental health services, for example, through the introduction of peer support services (sharing of expert-by-experience knowledge), and it has challenged the prevailing view that people with mental illness cannot recover.

Aims: Through this study, the researchers explored how family caregivers in a Chinese context conceptualise recovery, how caregivers interact with peer support workers (PSWs) and how they perceive peer support services. Read More

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http://dx.doi.org/10.1177/0020764019842287DOI Listing
April 2019
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Childbirth and prevention of bipolar disorder: an opportunity for change.

Lancet Psychiatry 2019 Apr 10. Epub 2019 Apr 10.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

The recent conceptualisation of bipolar disorder as a neuroprogressive illness has highlighted the potential importance of prevention and early intervention in high-risk populations. Undiagnosed bipolar disorder early in the disease course is associated with adverse clinical outcomes and impaired functioning for patients, which in turn has economic consequences. Despite the mounting evidence that childbirth is one of the most potent and specific triggers of manic symptoms, studies are not available on the effectiveness of targeted interventions in the prevention of bipolar disorder in women who have recently given birth. Read More

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http://dx.doi.org/10.1016/S2215-0366(19)30092-6DOI Listing
April 2019
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Tamoxifen has an anti-manic effect but not protect the brain against oxidative stress in an animal model of mania induced by ouabain.

J Psychiatr Res 2019 Mar 26;113:181-189. Epub 2019 Mar 26.

Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address:

Studies have suggested the involvement of oxidative stress in the physiopathology of bipolar disorder. Preclinical data have shown that PKC inhibitors may act as mood-stabilizing agents and protect the brain in animal models of mania. The present study aimed to evaluate the effects of Lithium (Li) or tamoxifen (TMX) on behavioral changes and oxidative stress parameters in an animal model of mania induced by ouabain (OUA). Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.03.020DOI Listing
March 2019
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