48,848 results match your criteria Bipolar Affective Disorder


Salivary melatonin onset in youth at familial risk for bipolar disorder.

Psychiatry Res 2019 Feb 6;274:49-57. Epub 2019 Feb 6.

Department of Psychiatry, University of Michigan, Ann arbor, MI, United States.

Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR). Adolescent participants (n = 12) were a mean age 14 ± 2.3 years and included 8 females and 4 males. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2019.02.013DOI Listing
February 2019

Fine-mapping scan of bipolar disorder susceptibility loci in Latino pedigrees.

Am J Med Genet B Neuropsychiatr Genet 2019 Feb 19. Epub 2019 Feb 19.

Center of Emphasis in Neurosciences, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas.

We previously identified bipolar disorder (BD) susceptibility loci on 8q24, 14q32, and 2q12-14 in a genome-wide nonparametric linkage screen in a Latino cohort. We now perform a fine mapping analysis using a dense map of additional SNPs to identify BD susceptibility genes within these regions. One thousand nine hundred and thirty-eight individuals with Latino ancestry (880 individuals with BD Type I or Schizoaffective, Bipolar Type) from 416 Latino pedigrees from the United States, Mexico, Costa Rica, and Guatemala were genotyped with 3,074 SNPs to provide dense coverage of the 8q24 (11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.b.32715DOI Listing
February 2019

Diet quality and eating patterns in euthymic bipolar patients.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1221-1238

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.

Objective: As mood disorders and obesity are interrelated, and both are linked to increased morbidity and mortality, risk factors for obesity should be identified and closely monitored in patients with bipolar disorder (BD). The aim of this study was to determine the diet quality of BD patients and to investigate its putative associations with comorbid obesity and disorders of carbohydrate metabolism, as well as the relationship between diet and clinical features of BD.

Patients And Methods: Eating patterns in 113 euthymic BD patients and 160 healthy control subjects were assessed using data obtained from a food frequency questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26355/eurrev_201902_17016DOI Listing
February 2019

[Evolution of the levels of the caregiver burden in bipolar patients' family members who participated in a psychoeducational workshop].

Vertex 2018 Jul;XXIX(140):288-298

Fundación Bipolares de la República Argentina (FUBIPA). Capítulo de Trastornos del Ánimo de la Asociación de Psiquiatras Argentinos (APSA).

Purpose: Caregiver burden is a variable which measures the impact of a chronic disease on the people who are closer to the patient. Different investigations have shown that the burden suffered by family members of patients with bipolar disorder is similar to that suffered by the relatives of schizophrenic patients and superior to the excessive strain caused by chronic diseases, such as diabetes. Lowering burden levels has been proved to improve family members' welfare and also to reduce patients' relapse indexes. Read More

View Article

Download full-text PDF

Source

The importance and depth of reproducibility in rodent models of psychiatric diseases.

Pharmacol Biochem Behav 2019 Mar;178:1-2

School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbb.2019.01.009DOI Listing

The Link between Thyroid Autoimmunity, Depression and Bipolar Disorder.

Open Med (Wars) 2019 16;14:52-58. Epub 2019 Jan 16.

Department of Obstetrics and Gynaecology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Depression and bipolar disorder are two major psychiatric illnesses whose pathophysiology remains elusive. Newly emerging data support the hypothesis that the dysfunction of the immune system might be a potential factor contributing to the development of these mental disorders. The most common organ affected by autoimmunity is the thyroid; therefore, the link between autoimmune thyroid disorders and mental illnesses has been studied since the 1930s. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/med-2019-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371203PMC
January 2019

Interpretable Dynamic Treatment Regimes.

J Am Stat Assoc 2018 14;113(524):1541-1549. Epub 2018 Nov 14.

Department of Statistics, NC State University.

Precision medicine is currently a topic of great interest in clinical and intervention science. A key component of precision medicine is that it is evidence-based, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01621459.2017.1345743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373443PMC
November 2018

The use of component-wise gradient boosting to assess the possible role of cognitive measures as markers of vulnerability to pediatric bipolar disorder.

Cogn Neuropsychiatry 2019 Feb 18:1-15. Epub 2019 Feb 18.

a Department of Psychiatry and Behavioral Sciences , The University of Texas Health Science Center at Houston , Houston , TX , USA.

Background And Aims: Cognitive impairments are primary hallmarks symptoms of bipolar disorder (BD). Whether these deficits are markers of vulnerability or symptoms of the disease is still unclear. This study used a component-wise gradient (CGB) machine learning algorithm to identify cognitive measures that could accurately differentiate pediatric BD, unaffected offspring of BD parents, and healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13546805.2019.1580190DOI Listing
February 2019

Distinct temporal brain dynamics in bipolar disorder and schizophrenia during emotion regulation.

Psychol Med 2019 Feb 18:1-9. Epub 2019 Feb 18.

University of Groningen, University Medical Center Groningen, Cognitive Neuroscience Center,Groningen,the Netherlands.

Background: Disturbances in emotion regulation (ER) are characteristic of both patients with bipolar disorder (BD) and schizophrenia (SZ). We investigated the temporal dynamics of brain activation during cognitive ER in BD and SZ to understand the contribution of temporal characteristics of disturbed ER to their unique and shared symptomatology.

Method: Forty-six participants performed an ER-task (BD, n = 15; SZ, n = 16; controls, n = 15) during functional magnetic resonance imaging, in which they were instructed to use cognitive reappraisal techniques to regulate their emotional responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0033291719000217DOI Listing
February 2019

Spanish validation of the Barcelona TEMPS-A questionnaire in patients with bipolar disorder and general population.

J Affect Disord 2019 Feb 12;249:199-207. Epub 2019 Feb 12.

Bipolar and Depression Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. Electronic address:

Background: The Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego (TEMPS-A) is a self-administered questionnaire intended to assess five affective temperaments: depressive, cyclothymic, hyperthymic, irritable and anxious. Our objective was to examine the psychometric properties of the TEMPS-A using a sample comprised by patients with bipolar disorder (BD) and healthy controls (HC) and to determine cut-off scores for each temperament.

Methods: Five hundred and ninety-eight individuals (327 BD and 271 HC) completed the TEMPS-A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.037DOI Listing
February 2019

Effects of illness duration on cognitive performances in bipolar depression are mediated by white matter microstructure.

J Affect Disord 2019 Feb 8;249:175-182. Epub 2019 Feb 8.

University Vita-Salute San Raffaele, Milano, Italy.

Background: Cognitive deficits are a core feature of bipolar disorder (BD), and persist during the euthymic phase. White matter (WM) microstructural abnormalities are widely considered a structural marker of BD. Features of illness chronicity, such as illness duration and number of mood episodes, have been associated with worsening of both clinical profile and brain structural alterations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.015DOI Listing
February 2019

Peripheral expression of long non-coding RNAs in bipolar patients.

J Affect Disord 2019 Feb 11;249:169-174. Epub 2019 Feb 11.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Long non-coding RNAs (lncRNAs) have established roles in the pathogenesis of diverse human disorders including neuropsychiatric disorders.

Methods: In the current study, we evaluated expression levels of six apoptosis-related lncRNAs (CCAT2, TUG1, PANDA, NEAT1, FAS-AS1 and OIP5-AS1) in the peripheral blood of bipolar disorder (BD) patients and healthy subjects to assess their contribution in the pathogenesis of BD.

Results: CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.034DOI Listing
February 2019

Whole-exome sequencing identifies variants associated with structural MRI markers in patients with bipolar disorders.

J Affect Disord 2019 Feb 11;249:159-168. Epub 2019 Feb 11.

Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea; Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Republic of Korea. Electronic address:

Background: Bipolar disorder (BD) is one of the most heritable psychiatric disorders. A growing number of whole-exome sequencing (WES) studies for BD has been performed, however, no research has examined the association between single nucleotide variants (SNVs) from WES and structural magnetic resonance imaging (MRI) data.

Methods: We sequenced whole-exomes in 53 patients with BD and 82 healthy control participants at an initial discovery stage and investigated the impacts of SNVs in risk genes from WES analysis on the cortical gray-matter thickness and integrity of white matter tracts and in the following stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.028DOI Listing
February 2019

Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders.

Cell Syst 2019 Jan 31. Epub 2019 Jan 31.

Institute for Systems Biology, Seattle, WA, USA; Institute of Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Transcriptional regulatory changes in the developing and adult brain are prominent features of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly understood. We integrated brain-specific DNase footprinting and TF-gene co-expression to reconstruct a transcriptional regulatory network (TRN) model for the human brain. We identified key regulator TFs whose predicted target genes were enriched for differentially expressed genes in the prefrontal cortex of individuals with psychiatric and neurodegenerative diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2019.01.002DOI Listing
January 2019

Long-acting injectable antipsychotics (LAIs) for maintenance treatment of bipolar and schizoaffective disorders: A systematic review.

Eur Neuropsychopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Barcelona Bipolar Disorders Program, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, 170 Villarroel st., Barcelona, Catalunya, Spain. Electronic address:

Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euroneuro.2019.02.003DOI Listing
February 2019

Risk of recurrence of mood disorders during pregnancy and the impact of medication: A systematic review.

J Affect Disord 2019 Feb 7;249:96-103. Epub 2019 Feb 7.

Amsterdam UMC, Vrije Universiteit Amsterdam, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Background: Mood disorders can be difficult to treat during pregnancy. There is still lack of evidence whether pregnancy influences their natural course and whether continuation of pharmacotherapy, despite potential risks for the unborn child, is beneficial in preventing recurrence of mood episodes during pregnancy.

Methods: Systematic review conducted according to the PRISMA guidelines, searching Pubmed, PsycINFO, Embase and Cochrane databases up till January 9th, 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.018DOI Listing
February 2019

Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population.

J Am Acad Child Adolesc Psychiatry 2019 Jan 9. Epub 2019 Jan 9.

Erasmus University Medical Center, Rotterdam, the Netherlands.

Objective: To examine the relationship between polygenic scores (PGS) for five major psychiatric disorders and two cognitive traits with brain MRI morphological measurements in a large population-based sample of children. Additionally, we tested whether differences in brain morphology mediated associations between PGS for psychiatric disorders and related behavioral phenotypes.

Method: The participants included 1,139 children from the Generation R Study assessed at 10 years-of-age with genotype and neuroimaging data available. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08908567193000
Publisher Site
http://dx.doi.org/10.1016/j.jaac.2018.09.443DOI Listing
January 2019
1 Read

Psychotic-Like Experiences in Offspring of Parents With Bipolar Disorder and Community Controls: A Longitudinal Study.

J Am Acad Child Adolesc Psychiatry 2018 Nov 2. Epub 2018 Nov 2.

University of Pittsburgh, PA.

Objective: To compare the prevalence and risk factors associated with Psychotic-Like-Experiences (PLE) in offspring of parents with bipolar disorder (BP) and offspring of community control parents.

Method: Delusional and hallucinatory subclinical psychotic experiences were evaluated at intake and longitudinally in a cohort study of 390 offspring of BP parents and 247 offspring of control parents aged 6-18 years old. The sample was followed up every 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaac.2018.09.440DOI Listing
November 2018

A Longitudinal Study of Family Functioning in Offspring of Bipolar Parents.

J Am Acad Child Adolesc Psychiatry 2018 Dec 18. Epub 2018 Dec 18.

Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA.

Objective: To compare the longitudinal course of family functioning in offspring of parents with bipolar disorder (BD), offspring of parents with non-BD psychopathology, and offspring of healthy control parents (HC).

Method: Offspring of BD parents (256 parents and 481 offspring), non-BD parents (82 parents and 162 offspring) and HC parents (88 parents and 175 offspring) ages 7-18 at intake, from the Bipolar Offspring Study (BIOS), were followed for an average of 4.3 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaac.2018.10.011DOI Listing
December 2018

Structural Brain Alterations in Youth With Psychosis and Bipolar Spectrum Symptoms.

J Am Acad Child Adolesc Psychiatry 2019 Jan 17. Epub 2019 Jan 17.

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; Center for Neurobehavioral Genetics, University of California, Los Angeles; University of California, Los Angeles.

Objective: Adults with established diagnoses of serious mental illness (bipolar disorder and schizophrenia) exhibit structural brain abnormalities, yet less is known about how such abnormalities manifest earlier in development.

Method: We analyzed the cross-sectional data publicly available from the Philadelphia Neurodevelopmental Cohort (PNC). Structural magnetic resonance neuroimaging data (sMRI) were collected on a subset of the PNC (N=989, ages 9-22 years old). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08908567193004
Publisher Site
http://dx.doi.org/10.1016/j.jaac.2018.11.012DOI Listing
January 2019
2 Reads

Feasibility and early outcomes of a tailored quitline protocol for smokers with mental health conditions.

Nicotine Tob Res 2019 Feb 15. Epub 2019 Feb 15.

Optum Healthcare Analytics.

Introduction: Adults with mental health conditions (MHCs) smoke at higher rates, are more nicotine dependent, and have more trouble quitting smoking than those without MHCs. About half of smokers who call state-funded quitlines report MHCs, and those with such conditions have cessation rates 8-10% lower than those without MHCs. This paper describes a clinical pilot of a tailored protocol for quitline callers with MHCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ntr/ntz023DOI Listing
February 2019

Antenatal caregiving representations among expectant mothers with severe mental illness: a cross-sectional study.

J Reprod Infant Psychol 2019 Feb 15:1-14. Epub 2019 Feb 15.

a Department of Psychology , University of Copenhagen , Copenhagen , Denmark.

Objective: The study explores predictors of antenatal caregiving representations among mothers with a history of severe mental illness (SMI).

Background: Attachment research has demonstrated that multifactorial assessment of antenatal caregiving representations predicts later maternal behaviour and child attachment. However, the field lacks research among clinical groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02646838.2019.1578868DOI Listing
February 2019

Postpartum Psychosis in a Young VA Patient: Diagnosis, Implications, and Treatment Recommendations.

Fed Pract 2018 Feb;35(2):28-33

is a Psychiatry Resident, and is an Assistant Clinical Professor of Psychiatry, both at the University of San Francisco Fresno Psychiatry Residency Program. Dr. Gedzior is a Staff Psychiatrist at VA Central California Health Care System in Fresno, California. is a Pharmacist at Valley Children's Hospital in Fresno.

Consider including a mood stabilizer with an antipsychotic medication because of the close association with bipolar disorder. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248224PMC
February 2018

Is care really shared? A systematic review of collaborative care (shared care) interventions for adult cancer patients with depression.

BMC Health Serv Res 2019 Feb 14;19(1):120. Epub 2019 Feb 14.

Discipline of Psychiatry, School of Medicine, The University of Queensland, Herston, Qld, Australia.

Background: Collaborative care involves active engagement of primary care and hospital physicians in shared care of patients beyond usual discharge summaries. This enhances community-based care and reduces dependence on specialists and hospitals. The model, successfully implemented in chronic care management, may have utility for treatment of depression in cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12913-019-3946-zDOI Listing
February 2019

Agmatine as a potential therapeutic intervention in bipolar depression: the preclinical landscape.

Expert Opin Ther Targets 2019 Feb 15. Epub 2019 Feb 15.

a Neuroscience Graduate Program, McMaster University , 1280 Main Street West, Hamilton , ON , Canada .

Introduction: Present antidepressant treatments are only helpful in a quarter of patients with bipolar depression, and new strategies are warranted. Increasing evidence suggests that accelerated polyamine metabolism is associated with the pathophysiology of depression. Polyamines regulate stress responses, inflammation, and neuronal signaling in the central and enteric nervous system. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
Publisher Site
http://dx.doi.org/10.1080/14728222.2019.1581764DOI Listing
February 2019
3 Reads

The associations between subjective and objective cognitive functioning across manic or hypomanic, depressed, and euthymic states in Chinese bipolar patients.

J Affect Disord 2019 Feb 6;249:73-81. Epub 2019 Feb 6.

School of Nursing, Sun Yat-sen University, Guangzhou 510078, China.

Background: Patients may present cognitive deficits during all stages of bipolar disorder (BD). Few studies have examined self-reported cognitive difficulties and its relation to neurocognitive dysfunction during symptomatic periods of BD. This study aimed to compare subjective cognitive functioning and explore associations between subjective and objective cognitive functioning across different BD clinical states, and investigate the predicting and moderating roles of mood symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.025DOI Listing
February 2019
1 Read

'Conceivably Neglected' - Are prescribers sufficiently aware of the risks of prescribing sodium valproate to women with mental illness?

Australas Psychiatry 2019 Feb 14:1039856219828175. Epub 2019 Feb 14.

Consultant Psychiatrist and staff specialist, Fellow Royal Australian and New Zealand College of Psychiatrists, Redcliffe-Caboolture Mental Health Service, Metro-North Mental Health Service, Brisbane, QLD, Australia.

Objectives:: To describe prescription of sodium valproate (SV) for bipolar mood disorder to potentially child-bearing women within one public mental health service and describe risks of fetal exposure, and safe prescribing practices among psychiatrists.

Methods:: A 24-month retrospective chart review with descriptive analysis; narrative review of literature and guidelines.

Results:: Review of 383 charts demonstrated prescription of valproate to 20% of 98 women aged 15-45, with little evidence of advice regarding risk and contraception. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1039856219828175DOI Listing
February 2019

High concentrations of serum interleukin-6 and interleukin-8 in patients with bipolar disorder.

Medicine (Baltimore) 2019 Feb;98(7):e14419

Department of Psychiatry, The Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu.

Immune system dysregulation plays a key role in the physiopathology of bipolar disorder (BD) and major depressive disorder (MDD). However, whether interleukins might be biomarkers to distinguish these 2 affective disorders is unclear. Here, we assessed the differences in serum levels of interleukin 6 (IL-6) and interleukin 8 (IL-8) as well as C-reactive protein (CRP) in patients with MDD and BD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014419DOI Listing
February 2019
8 Reads

Objective and biological markers in bipolar spectrum presentations.

Expert Rev Neurother 2019 Feb 14. Epub 2019 Feb 14.

a Department of Psychiatry , University of British Columbia , 2255 Wesbrook Mall, Vancouver , BC , Canada V6T 2A1.

Introduction: Subthreshold presentations of bipolarity (BSPs) pose a diagnostic conundrum, in terms of whether they should be conceptualized and treated similarly as traditionally defined bipolar disorders (BD). While it has been argued that BSPs are on a pathophysiologic continuum with traditionally defined BDs, there has been limited examination of biological and objective markers in these presentations to validate this assertion. Areas covered: The authors review studies examining genetic, neurobiological, cognitive and peripheral markers in BSPs, encompassing clinical and non-clinical populations with subthreshold hypo/manic symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1580145DOI Listing
February 2019
1 Read

Elevated Familial Cardiovascular Burden Among Adolescents With Familial Bipolar Disorder.

Front Psychiatry 2019 29;10. Epub 2019 Jan 29.

Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Bipolar disorder (BD) is one of the most heritable medical conditions, and certain phenotypic characteristics are especially familial in BD. BD is also strongly associated with elevated and premature cardiovascular disease (CVD) morbidity and mortality. Thus, far, little is known regarding the familiality of cardiovascular risk in BD. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fpsyt.2019.00008
Publisher Site
http://dx.doi.org/10.3389/fpsyt.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361809PMC
January 2019
3 Reads

Hormonal imbalance and pituitary adenoma during antipsychotic treatment in an adolescent with bipolar affective disorder.

Riv Psichiatr 2019 Jan-Feb;54(1):37-39

Child and Adolescent Psychiatry Department, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania.

In this paper we present the case of a female teenager patient who was diagnosed with bipolar affective disorder and during psychotropic treatment with risperidone, the prolactin levels ranged between 55 ng/mL and 85 ng/mL at monthly repeated dosing. During this period, the patient presented somatic alterations in her state of health. The patient benefited from brain imaging, which revealed that in sella turcica is distinguished a well-defined and relatively homogeneous formation, measuring approximately 11/8 mm, suggestive of a pituitary adenoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1708/3104.30939DOI Listing
February 2019
1 Read

Association of functioning and quality of life with objective and subjective measures of sleep and biological rhythms in major depressive and bipolar disorder.

Aust N Z J Psychiatry 2019 Feb 13:4867419829228. Epub 2019 Feb 13.

1 Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.

Objective:: Disruptions in biological rhythms and sleep are a core aspect of mood disorders, with sleep and rhythm changes frequently occurring prior to and during mood episodes. Wrist-worn actigraphs are increasingly utilized to measure ambulatory activity rhythm and sleep patterns.

Methods:: A comprehensive study using subjective and objective measures of sleep and biological rhythms was conducted in 111 participants (40 healthy volunteers [HC], 38 with major depressive disorder [MDD] and 33 with bipolar disorder [BD]). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0004867419829228DOI Listing
February 2019

Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study.

Nutrients 2019 Feb 12;11(2). Epub 2019 Feb 12.

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 4300700, China.

We applied Mendelian randomization analyses to investigate the potential causality between blood minerals (calcium, magnesium, iron, copper, and zinc) and osteoporosis (OP), gout, rheumatoid arthritis (RA), type 2 diabetes (T2D), Alzheimer's disease (AD), bipolar disorder (BD), schizophrenia , Parkinson's disease and major depressive disorder. Single nucleotide polymorphisms (SNPs) that are independent (² < 0.01) and are strongly related to minerals ( < 5 × 10) are selected as instrumental variables. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2072-6643/11/2/378
Publisher Site
http://dx.doi.org/10.3390/nu11020378DOI Listing
February 2019
2 Reads

Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder.

J Affect Disord 2019 Feb 6;249:63-72. Epub 2019 Feb 6.

Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland; Department of Psychiatry, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Psychiatry, Länsi-Pohja Healthcare District; Department of Psychiatry, the Middle Ostrobothnia Central Hospital, Soite; Mental Health Services, Joint Municipal Authority of Wellbeing in Raahe District; Mental Health Services and Basic Health Care District of Kallio; and Department of Psychiatry, Kainuu Central Hospital, Kainuu Social and Healthcare District, Finland.

Background: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders.

Methods: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.011DOI Listing
February 2019
1 Read

Agomelatine for depression: expanding the horizons?

Expert Opin Pharmacother 2019 Feb 13:1-10. Epub 2019 Feb 13.

a Department of Psychiatry , University of Melbourne, Austin Hospital , Heidelberg , Australia.

Introduction: Agomelatine is an antidepressant with unique pharmacological actions; it is both a melatonin agonist and selective serotonin antagonist. Both actions combined are necessary for antidepressant efficacy. Effects on melatonin receptors enable resynchronisation of disrupted circadian rhythms with beneficial effects on sleep patterns. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2019.1574747DOI Listing
February 2019

The role of pre-, peri-, and postnatal risk factors in bipolar disorder and adult ADHD.

J Neural Transm (Vienna) 2019 Feb 13. Epub 2019 Feb 13.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Heinrich-Hoffmann-Str. 10, 60528, Frankfurt am Main, Germany.

Gene-environment-development interactions are suggested to play a crucial role in psychiatric disorders. However, it is not clear if there are specific risk gene interactions with particular pre-, peri-, and postnatal risk factors for distinct disorders, such as adult attention-deficit-/hyperactivity disorder (aADHD) and bipolar disorder (BD). In this pilot study, the first aim was to investigate retrospective self-reports of pre-, peri-, and postnatal complications and risk factors from 126 participants (aADHD, BD, and healthy controls) and their mothers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01983-4DOI Listing
February 2019
1 Read

Addressing Mental Health Concerns in Primary Care: Practices Among Medical Residents in a Rural Setting.

J Clin Psychol Med Settings 2019 Feb 13. Epub 2019 Feb 13.

Elmira College, Elmira, USA.

Behavioral health issues like anxiety and depression negatively impact numerous aspects of primary care, including medical regimen adherence, communication, physical well-being, and engagement in beneficial health behaviors. This study aimed to examine internal and family medicine residents': (1) patterns of addressing mental health concerns (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10880-019-09609-3DOI Listing
February 2019

[Breakthrough in understanding the molecular causes of psychiatric disorders].

Nervenarzt 2019 Feb;90(2):99-106

Institut für Humangenetik, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland.

A long-established hypothesis is that genetic factors contribute to the development of psychiatric diseases, including common illnesses such as schizophrenia and the affective disorders; however, reliable molecular identification of these factors represents a far more recent innovation. This has been rendered possible by technological advances in the individual characterization of the human genome and the combining of large genetic datasets at the international level. For the first time, the results of genome-wide analyses provide researchers with systematic insights into disease-relevant biological mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00115-018-0670-6DOI Listing
February 2019

Comorbidity of Bipolar-I Disorder and Conduct Disorder: A Familial Risk Analysis.

Acta Psychiatr Scand 2019 Feb 13. Epub 2019 Feb 13.

Pediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA.

Objective: To investigate the association between pediatric bipolar-I (BP-I) disorder and conduct disorder (CD) using familial risk analysis.

Method: We compared diagnoses in relatives of youth in four proband groups defined by the presence or absence of BP-I and CD: 1) probands with neither CD nor BP-I (probands: N=550; relatives: N=1,656), 2) probands with CD and without BP-I (probands: N=40; relatives: N=127), 3) probands with BP-I and without CD (probands: N=197; relatives: N=579), and 4) probands with both CD and BP-I (probands: N=176; relatives: N=488). All subjects were evaluated with structured diagnostic interviews and diagnoses of relatives were made blind to the diagnoses of probands. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/acps.13013
Publisher Site
http://dx.doi.org/10.1111/acps.13013DOI Listing
February 2019
3 Reads

Targeting the immune system in the treatment of bipolar disorder.

Psychopharmacology (Berl) 2019 Feb 13. Epub 2019 Feb 13.

Mood Disorder Psychopharmacology Unit, Department of Psychiatry and Pharmacology, University Health Network, University of Toronto, 399 Bathurst Street, MP 9-325, Toronto, ON, M5T 2S8, Canada.

Rationale: Immune dysfunction has been strongly implicated in the pathophysiology of bipolar disorder (BD). As such, numerous clinical trials have investigated the effects of anti-inflammatory agents in the treatment of BD.

Objectives: Review clinical studies evaluating the effects of anti-inflammatory agents in the treatment of BD during all illness phases (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00213-019-5175-xDOI Listing
February 2019

The 'SILENT Alarm': When History Taking Reveals a Potentially Fatal Toxicity.

Eur J Case Rep Intern Med 2018 26;5(6):000843. Epub 2018 Jun 26.

Internal Medicine 'T', Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, affiliated to the Sackler School of Medicine, Tel-Aviv, Israel.

Introduction: The combination of acute/sub-acute neurological and metabolic derangements should always raise the suspicion of toxicity, either endogenous or exogenous. The adverse effects of psychiatric medications are especially difficult to determine since the psychiatric background of patients is often inaccessible.

Clinical Presentation: A 66-year-old man presented to the emergency department with dysarthria and uncontrolled tremor, rapidly deteriorating into a complex of severe neurological and metabolic derangements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346880PMC
June 2018
2 Reads

Baseline and follow-up activity and functional connectivity in reward neural circuitries in offspring at risk for bipolar disorder.

Neuropsychopharmacology 2019 Feb 13. Epub 2019 Feb 13.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Bipolar disorder (BD) is a serious psychiatric illness with demonstrated abnormalities in reward processing circuitry. Examining this circuitry in youth at familial risk for BD may provide further insight into the underlying mechanisms of BD development. In this study, we compared offspring of bipolar parents (OBP, n = 32), offspring of comparison parents with non-BD psychopathology (OCP, n = 36), and offspring of healthy parents (OHP, n = 39) during a functional magnetic resonance imaging reward processing task. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41386-019-0339-2DOI Listing
February 2019
1 Read

The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study.

Trials 2019 Feb 12;20(1):120. Epub 2019 Feb 12.

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.

Background: The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) antagonists. These drugs, licensed to treat hypertension and angina, have previously been used in bipolar disorder, but without clear results. Neither is much known about the broader effects of these drugs on the brain and behaviour. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3175-0DOI Listing
February 2019
1 Read

Cariprazine for the treatment of bipolar depression: a review.

Expert Rev Neurother 2019 Feb 12. Epub 2019 Feb 12.

a Mood Disorders Psychopharmacology Unit , University Health Network , Toronto , Canada.

Introduction: Depressive symptoms and episodes dominate the course of bipolar disorder. The morbidity of bipolar disorder is disproportionately mediated by depressive symptoms; economic costs of bipolar disorder are also disproportionately due to unremitting depressive symptoms. Relatively few treatment options have established unequivocal efficacy in the treatment of bipolar depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737175.2019.1580571DOI Listing
February 2019
1 Read

Successful lithium treatment in a patient on hemodialysis.

Bipolar Disord 2019 Feb 12. Epub 2019 Feb 12.

Antes Center for Mental Health Care, Rotterdam, the Netherlands.

In 2010 a 69-year old patient with bipolar I disorder, type 2 diabetes and hypertension was referred to the Nephrology outpatient clinic of the Maasstad Hospital for progressive kidney disease. Her creatinine was 205 μmol/L (estimated Glomerular Filtration Rate (eGFR) 22 mL/min/1.73m ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bdi.12756DOI Listing
February 2019
1 Read

Metabolomic Biomarkers in Mental Disorders: Bipolar Disorder and Schizophrenia.

Adv Exp Med Biol 2019 ;1118:271-293

Laboratory of Chemical Biology, Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Psychiatric disorders are some of the most impairing human diseases. Among them, bipolar disorder and schizophrenia are the most common. Both have complicated diagnostics due to their phenotypic, biological, and genetic heterogeneity, unknown etiology, and the underlying biological pathways, and molecular mechanisms are still not completely understood. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-3-030-05542-4_14
Publisher Site
http://dx.doi.org/10.1007/978-3-030-05542-4_14DOI Listing
January 2019
3 Reads

Interactome Studies of Psychiatric Disorders.

Adv Exp Med Biol 2019 ;1118:163-173

Proteomics and Biomarkers, Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.

High comorbidity and complexity have precluded reliable diagnostic assessment and treatment of psychiatric disorders. Impaired molecular interactions may be relevant for underlying mechanisms of psychiatric disorders but by and large remain unknown. With the help of a number of publicly available databases and various technological tools, recent research has filled the paucity of information by generating a novel dataset of psychiatric interactomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-05542-4_8DOI Listing
January 2019