52,183 results match your criteria Bipolar Affective Disorder


Physical health among people with serious mental illness in the face of COVID-19: Concerns and mitigation strategies.

Gen Hosp Psychiatry 2020 Jun 30;66:30-33. Epub 2020 Jun 30.

Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

COVID-19 can worsen the physical health of individuals with serious mental illness, a vulnerable group already facing physical health disparities. COVID-19 is further reducing access to physical health care due to shutdown of services deemed "non-urgent" and overcrowding of emergency services. Management of chronic diseases, highly prevalent in this group, is undermined due to exacerbation of psychiatric disorders, reduction in availability of social support, and worsening of negative social determinants of health. Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2020.06.013DOI Listing

How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings.

Hum Brain Mapp 2020 Jul 9. Epub 2020 Jul 9.

Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, CHU Ste-Justine, Montreal, Canada.

Alcohol use disorder (AUD) and cannabis use disorder (CUD) are associated with brain alterations particularly involving fronto-cerebellar and meso-cortico-limbic circuitry. However, such abnormalities have additionally been reported in other psychiatric conditions, and until recently there has been few large-scale investigations to compare such findings. The current study uses the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium method of standardising structural brain measures to quantify case-control differences and to compare brain-correlates of substance use disorders with those published in relation to other psychiatric disorders. Read More

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http://dx.doi.org/10.1002/hbm.25114DOI Listing

In vivo human brain expression of histone deacetylases in bipolar disorder.

Transl Psychiatry 2020 Jul 8;10(1):224. Epub 2020 Jul 8.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.

The etiology of bipolar disorder (BD) is unknown and the neurobiological underpinnings are not fully understood. Both genetic and environmental factors contribute to the risk of BD, which may be linked through epigenetic mechanisms, including those regulated by histone deacetylase (HDAC) enzymes. This study measures in vivo HDAC expression in individuals with BD for the first time using the HDAC-specific radiotracer [C]Martinostat. Read More

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http://dx.doi.org/10.1038/s41398-020-00911-5DOI Listing

Association of Outdoor Artificial Light at Night With Mental Disorders and Sleep Patterns Among US Adolescents.

JAMA Psychiatry 2020 Jul 8. Epub 2020 Jul 8.

Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland.

Importance: Indoor nighttime light exposure influences sleep and circadian rhythms and is known to affect mood-associated brain circuits in animals. However, little is known about the association between levels of nighttime outdoor light and sleep and mental health in the population, especially among adolescents.

Objective: To estimate associations of outdoor artificial light at night (ALAN) with sleep patterns and past-year mental disorder among US adolescents. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2020.1935DOI Listing

Correlates of the Abnormal Involuntary Movement Scale in Veterans With Tardive Dyskinesia.

J Clin Psychopharmacol 2020 Jul/Aug;40(4):373-380

From the Behavioral Health Service, Corporal Michael J. Crescenz VA Medical Center.

Purpose/background: To add to limited evidence on the Abnormal Involuntary Movement Scale (AIMS) as a measure of tardive dyskinesia (TD) in clinical practice settings, the characteristics and correlates of AIMS scores were assessed.

Methods/procedures: Veterans with schizophrenia/schizoaffective, bipolar, or major depressive disorders receiving antipsychotics and at least 1 AIMS score during October 1, 2014, to September 30, 2015, were identified. Tardive dyskinesia was determined by the International Classification of Diseases, Ninth Revision, Clinical Modification, codes. Read More

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http://dx.doi.org/10.1097/JCP.0000000000001229DOI Listing

Nitrous oxide as a putative novel dual-mechanism treatment for bipolar depression: Proof-of-concept study design and methodology.

Contemp Clin Trials Commun 2020 Sep 23;19:100600. Epub 2020 Jun 23.

Pharmacology and Toxicology Department, University of Toronto, Toronto, Ontario, Canada.

Introduction: Depressive symptoms predominate in the course of bipolar disorder (BD) and there is an urgent need to evaluate novel application of repurposed compounds that act on pre-specified treatment targets. Several lines of reasoning suggest that nitrous oxide (NO) is an ideal medication to study as a potential treatment and as a strategy to identify the underlying pathophysiology of bipolar depression. NO is a potent cerebral vasodilator and there is compelling evidence of reduced frontal cerebral blood flow (CBF; i. Read More

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http://dx.doi.org/10.1016/j.conctc.2020.100600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327241PMC
September 2020

DISC1 Regulates Mitochondrial Trafficking in a Miro1-GTP-Dependent Manner.

Front Cell Dev Biol 2020 19;8:449. Epub 2020 Jun 19.

Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

The disrupted in schizophrenia 1 (DISC1) protein is implicated in major mental illnesses including schizophrenia and bipolar disorder. A key feature of psychiatric disease is aberrant synaptic communication. Correct synaptic transmission is dependent on spatiotemporally regulated energy provision and calcium buffering. Read More

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http://dx.doi.org/10.3389/fcell.2020.00449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317294PMC

Efficacy and Safety of Quetiapine for Pediatric Bipolar Depression: A Systematic Review of Randomized Clinical Trials.

Cureus 2020 Jun 2;12(6):e8407. Epub 2020 Jun 2.

Psychiatry, Griffin Memorial Hospital, Norman, USA.

Quetiapine is a second-generation antipsychotic (SGA) approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia, mania, and aggression in children and adolescents. It is also commonly used as an off-label medication to treat children and adolescents with bipolar depression, although the FDA has not approved quetiapine for this purpose. We conducted a systematic review of randomized clinical trials (RCTs) using the MEDLINE database and included two studies that met our inclusion criteria. Read More

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http://dx.doi.org/10.7759/cureus.8407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331915PMC

Pharmacological Manipulation of K 7 Channels as a New Therapeutic Tool for Multiple Brain Disorders.

Front Physiol 2020 19;11:688. Epub 2020 Jun 19.

Department of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, TX, United States.

K 7 ("M-type," KCNQ) K currents, play dominant roles in controlling neuronal excitability. They act as a "brake" against hyperexcitable states in the central and peripheral nervous systems. Pharmacological augmentation of M current has been developed for controlling epileptic seizures, although current pharmacological tools are uneven in practical usefulness. Read More

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http://dx.doi.org/10.3389/fphys.2020.00688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317068PMC

Advances toward precision medicine for bipolar disorder: mechanisms & molecules.

Mol Psychiatry 2020 Jul 7. Epub 2020 Jul 7.

Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%, the effective treatment, and prevention of bipolar disorder represents an area of significant unmet medical need. While more than half a century has passed since the introduction of lithium into widespread use at the birth of modern psychopharmacology, that medication remains a mainstay for the acute treatment and prevention of recurrent mania/hypomania and depression that characterize bipolar disorder. However, the continued limited understanding of how lithium modulates affective behavior and lack of validated cellular and animal models have resulted in obstacles to discovering more effective mood stabilizers with fewer adverse side effects. Read More

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http://dx.doi.org/10.1038/s41380-020-0831-4DOI Listing

Childhood maltreatment and HPA axis gene expression in bipolar disorders: A gene network analysis.

Psychoneuroendocrinology 2020 Jun 6;120:104753. Epub 2020 Jun 6.

Unité INSERM UMR-S 1144 Optimisation thérapeutique en Neuropsychopharmacologie, Paris, France.

Introduction: Bipolar disorder (BD) is highly associated with childhood maltreatment (CM), the exposure to such early adversity being suggested to disrupt the expression of several biological pathways. This study aims at exploring associations between the mRNA levels of 9 HPA axis genes in lymphoblastoid cell lines from patients with BD according to their self-reported exposure to CM.

Methods: The sample consisted of 33 Caucasian patients with a diagnosis of BD type 1, assessed for the exposure to CM with the Childhood Trauma Questionnaire (CTQ). Read More

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http://dx.doi.org/10.1016/j.psyneuen.2020.104753DOI Listing

Cognitive performance and psychosocial functioning in unaffected siblings of bipolar disorder patients in comparison with healthy controls.

Asian J Psychiatr 2020 Jun 29;54:102246. Epub 2020 Jun 29.

Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

We aimed to evaluate the cognitive domains for endophenotypes and their bearing on psychosocial functioning in unaffected siblings of patients with bipolar type I disorder (BD-I). We recruited unaffected siblings (n = 60) and age (±2 years), gender and education-matched healthy control subjects (n = 60) after screening with Structured clinical interview for DSM-IV-TR axis I disorders (SCID-I) - Research Version, Young Mania rating scale (YMRS), Hamilton depression rating scale (HDRS) and Family Interview for Genetic Studies scale (FIGS). Cognitive functioning was evaluated using Addenbrooke's Cognitive Examination III Revised (ACE-III R) and Trail making tests A and B, whereas psychosocial functioning was evaluated using the Social and Occupational Functioning Assessment Scale (SOFAS). Read More

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http://dx.doi.org/10.1016/j.ajp.2020.102246DOI Listing

Novel therapeutic targets in mood disorders: Pentoxifylline (PTX) as a candidate treatment.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 4:110032. Epub 2020 Jul 4.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

Numerous pharmacological treatments for mood disorders are currently available; however, rates of treatment resistance, relapse and recurrence remain high. Therefore, novel treatments acting outside of the conventionally targeted monoamine system are urgently needed to improve patient outcomes. Emerging and converging evidence suggests that immune dysfunction, oxidative stress, impaired cerebral blood flow (CBF) and decreased neurotrophic factors all contribute to mood disorder pathophysiology and are therefore treatment targets of interest. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.110032DOI Listing

Applicability of two violence risk assessment tools in a psychiatric prison hospital population.

Behav Sci Law 2020 Jul 7. Epub 2020 Jul 7.

Universitätsklinikum Hamburg-Eppendorf, Institute of Sex Research, Sexual Medicine and Forensic Psychiatry, Hamburg, Germany.

The risk of violent behavior is known to be higher for patients who suffer from a severe mental disorder. However, specific prediction tools for clinical work in prison psychiatry are lacking. In this single-center study, two violence risk assessment tools (Forensic Psychiatry and Violence Tool, "FoVOx," and Mental Illness and Violence Tool, "OxMIV") were applied to a prison hospital population with a primary psychotic or bipolar disorder and subsequently compared. Read More

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http://dx.doi.org/10.1002/bsl.2474DOI Listing

Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection.

Int J Bipolar Disord 2020 Jul 4;8(1):23. Epub 2020 Jul 4.

Department of Psychiatry, University Hospital, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.

Background: Treatment in bipolar disorder (BD) is commonly applied as a multimodal therapy based on decision algorithms that lack an integrative understanding of molecular mechanisms or a biomarker associated clinical outcome measure. Pharmacogenetics/genomics study the individual genetic variation associated with drug response. This selective review of pharmacogenomics and pharmacogenomic testing (PGT) in BD will focus on candidate genes and genome wide association studies of pharmacokinetic drug metabolism and pharmacodynamic drug response/adverse event, and the potential role of decision support tools that incorporate multiple genotype/phenotype drug recommendations. Read More

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http://dx.doi.org/10.1186/s40345-020-00184-3DOI Listing

Older molecular brain age in severe mental illness.

Mol Psychiatry 2020 Jul 6. Epub 2020 Jul 6.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15312, USA.

Psychiatric disorders are associated with accelerated aging and enhanced risk for neurodegenerative disorders. Brain aging is associated with molecular, cellular, and structural changes that are robust on the group level, yet show substantial inter-individual variability. Here we assessed deviations in gene expression from normal age-dependent trajectories, and tested their validity as predictors of risk for major mental illnesses and neurodegenerative disorders. Read More

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http://dx.doi.org/10.1038/s41380-020-0834-1DOI Listing

Metabolic and psychiatric effects of acyl coenzyme A binding protein (ACBP)/diazepam binding inhibitor (DBI).

Cell Death Dis 2020 Jul 6;11(7):502. Epub 2020 Jul 6.

Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France.

Acyl coenzyme A binding protein (ACBP), also known as diazepam binding inhibitor (DBI) is a multifunctional protein with an intracellular action (as ACBP), as well as with an extracellular role (as DBI). The plasma levels of soluble ACBP/DBI are elevated in human obesity and reduced in anorexia nervosa. Accumulating evidence indicates that genetic or antibody-mediated neutralization of ACBP/DBI has anorexigenic effects, thus inhibiting food intake and inducing lipo-catabolic reactions in mice. Read More

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http://dx.doi.org/10.1038/s41419-020-2716-5DOI Listing
July 2020
5.014 Impact Factor

[Retinal investigations in patients with major depressive disorder, bipolar disorder or schizophrenia: A review of the literature].

J Fr Ophtalmol 2020 Jul 3. Epub 2020 Jul 3.

CHU de Nancy, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address:

Major depressive disorder, bipolar disorder and schizophrenia are currently among the most common psychiatric disorders, known to constitute a serious public health issue in terms of morbidity, mortality and functional handicap. Their pathophysiology is still unclear, but there is now increasing evidence supporting the existence of abnormalities of neurotransmission. As the retina is an extension of the central nervous system, it may be an interesting site of study which might provide a better understanding of the pathophysiology of psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.jfo.2019.10.029DOI Listing

Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.

BMC Psychiatry 2020 Jul 6;20(1):354. Epub 2020 Jul 6.

University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH, USA.

Background: Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use.

Methods: Adults with self-reported physician-diagnosed BD-I (N = 200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. Read More

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http://dx.doi.org/10.1186/s12888-020-02767-xDOI Listing

Augmenting Evidence-Based Care With a Texting Mobile Interventionist: A Pilot Randomized Controlled Trial.

Psychiatr Serv 2020 Jul 7:appips202000239. Epub 2020 Jul 7.

Department of Psychiatry and Behavioral Sciences, BRiTE Center, University of Washington, Seattle (Ben-Zeev, Buck, Meller, Hallgren); Department of Psychological and Brain Sciences, Dartmouth College, and Department of Psychiatry, Dartmouth Geisel School of Medicine, Hanover, New Hampshire (Hudenko).

Objective: This study aimed to evaluate the feasibility and clinical utility of training intensive psychiatric community care team members to serve as "mobile interventionists" who engage patients in recovery-oriented texting exchanges.

Methods: A 3-month pilot randomized controlled trial was conducted to compare the mobile interventionist approach as an add-on to assertive community treatment (ACT) versus ACT alone. Participants were 49 individuals with serious mental illness (62% with schizophrenia/schizoaffective disorder, 24% with bipolar disorder, and 14% with depression). Read More

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http://dx.doi.org/10.1176/appi.ps.202000239DOI Listing

Clinical Severity and Calcium Metabolism in Patients with Bipolar Disorder.

Brain Sci 2020 Jul 1;10(7). Epub 2020 Jul 1.

Department of Psychiatry, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.

Parathyroid hormone (PTH), vitamin D and serum calcium play a key role in several physiological and pathological conditions. Vitamin D and PTH receptors are largely expressed in the central nervous system and are involved in the modulation of inflammatory responses. Few studies investigated the association between calcium homeostasis imbalance and psychiatric disorders. Read More

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http://dx.doi.org/10.3390/brainsci10070417DOI Listing

Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study.

Brain Sci 2020 Jun 30;10(7). Epub 2020 Jun 30.

Department of Psychiatry, Pomeranian University of Medicine, 71-460 Szczecin, Poland.

Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The aim of this study was to evaluate the mobilization of stem cells into peripheral blood, in patients with bipolar disorder during stable phase, not treated with lithium salts. Read More

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http://dx.doi.org/10.3390/brainsci10070408DOI Listing

Links between Child and Adolescent Psychiatric Disorders and Cardiovascular Risk.

Can J Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Psychiatry, Hospital for Sick Children Department of Psychiatry, Faculty of Medicine, University of Toronto.

This narrative review, emphasizing children and adolescents, addresses the link between five psychiatric disorders and cardiovascular risk: attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, anxiety disorders, depression, and bipolar disorders. The evidence regarding cardiovascular risk factors, non-invasive measures of early atherosclerosis, and cardiovascular disease prevalence and/or mortality is summarized. Whereas multiple studies have examined stimulant treatment of ADHD in relation to cardiovascular death, and autonomic-vagal function in autism spectrum disorders, little is known regarding atherosclerotic cardiovascular disease in these conditions. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.06.023DOI Listing

Relationship Between Clozapine Levels and Acute Inflammatory Stress.

Prim Care Companion CNS Disord 2020 Jul 2;22(4). Epub 2020 Jul 2.

Napa State Hospital, 2100 Napa Vallejo Hwy, Napa, CA 94558.

Stress-induced changes in pharmacokinetics can significantly alter the plasma levels of some drugs such as clozapine. This report describes the case of a middle-aged man with schizoaffective disorder, bipolar type who showed sustained elevation in clozapine levels 3 days after discontinuation. Before the clozapine levels were drawn, he had developed acute bacterial pneumonia and signs of acute bacterial meningitis followed by neuroleptic malignant syndrome after he received multiple doses of intravenous haloperidol for worsening psychosis and aggressive behavior. Read More

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http://dx.doi.org/10.4088/PCC.19br02586DOI Listing

Polygenic prediction of the risk of perinatal depressive symptoms.

Depress Anxiety 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Background: Perinatal depression carries adverse effects on maternal health and child development, but genetic underpinnings remain unclear. We investigated the polygenic risk of perinatal depressive symptoms.

Methods: About 742 women from the prospective Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction cohort were genotyped and completed the Center for Epidemiologic Studies Depression scale 14 times during the prenatal period and twice up to 12 months postpartum. Read More

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http://dx.doi.org/10.1002/da.23066DOI Listing

Are eating disorders associated with bipolar disorder type I? Results of a Lebanese case-control study.

Perspect Psychiatr Care 2020 Jul 5. Epub 2020 Jul 5.

INSPECT-LB: Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie- Liban, Beirut, Lebanon.

Objectives: To assess the association between disordered eating and bipolar disorder (BD).

Methods/design: A case-control study, conducted between April and September 2018, enrolled 50 patients and 50 controls.

Results: Higher eating attitude test scores were significantly associated with the presence of BD. Read More

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http://dx.doi.org/10.1111/ppc.12567DOI Listing

Mood Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome-Wide Association Study.

Clin Pharmacol Ther 2020 Jul 5. Epub 2020 Jul 5.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Several anti-epileptic drugs (AED) have FDA approval for use as mood stabilizers in bipolar disorder (BD), but not all BD patients respond to these AED mood stabilizers (AED-MS). To identify genetic polymorphisms that contribute to the variability in AED-MS response, we performed a discovery genome-wide association study of 199 BD patients from the Mayo Clinic Bipolar Disorder Biobank. Most of these patients had been treated with the AED-MS valproate and/or lamotrigine. Read More

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http://dx.doi.org/10.1002/cpt.1982DOI Listing

[Inbreeding and serious mental illness in the first Spanish Bourbons].

Authors:
A Royuela-Rico

Rev Neurol 2020 Jul;71(2):61-68

Complejo Asistencial de Palencia-Hospital San Telmo, Palencia, España.

Introduction: There is an argument about inbreeding as a risk factor in the development of major mental illnesses like bipolar disorder or schizophrenia. The genealogical trees of European royal dynasties represent an opportunity to study this relationship. Felipe V was the first Bourbon king to rule in Spain, who was thought to have possibly suffered a severe mental disorder. Read More

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http://dx.doi.org/10.33588/rn.7102.2019508DOI Listing

A meta-analysis comparing cognitive function across the mood/psychosis diagnostic spectrum.

Psychol Med 2020 Jun 22:1-9. Epub 2020 Jun 22.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.

Background: The nature and degree of cognitive impairments in schizoaffective disorder is not well established. The aim of this meta-analysis was to characterise cognitive functioning in schizoaffective disorder and compare it with cognition in schizophrenia and bipolar disorder. Schizoaffective disorder was considered both as a single category and as its two diagnostic subtypes, bipolar and depressive disorder. Read More

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http://dx.doi.org/10.1017/S0033291720002020DOI Listing

Correspondence: Actigraphic patterns, impulsivity and mood instability in bipolar disorder, borderline personality disorder and healthy controls.

Acta Psychiatr Scand 2020 Jul 5. Epub 2020 Jul 5.

Psychiatry, McGill University Faculty of Medicine, Montreal, Quebec, Canada.

We would like to commend McGowan and colleagues for their study addressing shared core symptoms of Borderline Personality Disorder (BPD) and Bipolar Disorder (BD) (1). These researchers established significant correlations between dysregulated circadian rest-activity variables (including low interdaily stability and weak amplitude) and symptoms of impulsivity and mood instability among their study participants with BPD. These patterns were neither observed in participants with BD nor in healthy controls. Read More

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http://dx.doi.org/10.1111/acps.13207DOI Listing

From putative brain tumor marker to high cognitive abilities: emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.

J Chem Neuroanat 2020 Jul 2:101846. Epub 2020 Jul 2.

Department of Psychiatry, Otto-von-Guericke University, Magdeburg, Germany.

ADAM (a disintergin and metalloprotease) 12 is a member of the large family of multidomain metalloprotease-disintegrins, which possess cell-binding and metalloprotease properties. The enzyme is responsible for the shedding of a number of membrane-bound proteins (heparin-binding-EGF, insulin-like growth factor 2-binding proteins 3 and 5, oxytocinase, glycoprotein non-metastatic melanoma protein B and basigin). In rat and human CNS, ADAM12 is predominantly localized in white and gray matter oligodendrocytes. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2020.101846DOI Listing

Frequency-specific alteration of functional connectivity density in bipolar disorder depression.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 1:110026. Epub 2020 Jul 1.

The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; MOE Key Lab for Neuroinformation|MOE Key Lab for Neuroinformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, China; Department of Radiology, First Affiliated Hospital to Army Medical University, Chongqing, China. Electronic address:

Functional dysconnectivity has been widely reported in bipolar disorder during depressive episodes (BDD). However, the frequency-specific alterations of functional connectivity (FC) in BDD remain poorly understood. To address this issue, the FC patterns across slow-5 (0. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.110026DOI Listing

The influence of stage of illness on functional outcomes after psychological treatment in bipolar disorder: A systematic review.

Bipolar Disord 2020 Jul 4. Epub 2020 Jul 4.

Centre for Mental Health, Faculty of Health Arts and Design, Swinburne University, Melbourne, Australia.

Objectives: The aim of this study was to advance understanding of stage of illness in bipolar disorder (BD), by interrogating the literature for evidence of an influence of stage of illness on functional (i.e., non-symptom) outcomes following psychosocial intervention. Read More

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http://dx.doi.org/10.1111/bdi.12974DOI Listing

A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Atorvastatin for Nephrogenic Diabetes Insipidus in Lithium-Users.

Bipolar Disord 2020 Jul 4. Epub 2020 Jul 4.

Geri-PARTy Research Group, Jewish General Hospital, Montreal, Canada.

Objective: Lithium remains an important treatment for mood disorders but is associated with kidney disease. Nephrogenic diabetes insipidus (NDI) is associated with up to 3-fold risk of incident chronic kidney disease amongst lithium users. There is limited randomized controlled trials (RCT) for treatments of lithium-induced NDI, and existing therapies can be poorly tolerated. Read More

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http://dx.doi.org/10.1111/bdi.12973DOI Listing

Transient effects of multi-infusion ketamine augmentation on treatment-resistant depressive symptoms in patients with treatment-resistant bipolar depression - An open-label three-week pilot study.

Brain Behav 2020 Jul 3:e01674. Epub 2020 Jul 3.

Department of Psychiatry Wenzhou Seventh People's Hospital, Wenzhou, China.

Introduction: While the psychiatric benefits of ketamine have been verified through clinical trials, there is limited information about ketamine augmentation in patients with treatment-resistant bipolar depression (TRBPD). Hence, in the present study, we investigate the therapeutic efficacy and functional brain alterations associated with multi-infusion ketamine augmentation in patients with TRBPD.

Methods: The present three-week study included 38 patients with TRBPD, all of whom received a series of nine ketamine injections over the study period. Read More

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http://dx.doi.org/10.1002/brb3.1674DOI Listing

Bipolar disorder in megalencephalic leukoencephalopathy with subcortical cysts: a case report.

BMC Psychiatry 2020 Jul 3;20(1):349. Epub 2020 Jul 3.

Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Tokyo, 187-8551, Japan.

Background: Megalencephalic leukoencephalopathy with subcortical cysts (MLC), or Van der Knaap disease, is a rare spongiform leukodystrophy that is characterized by macrocephaly, progressive motor dysfunction, and mild mental retardation. It is very rare for mental illness such as psychotic disorders, affective disorders and anxiety disorders to occur in MLC.

Case Presentation: A 17-year-old boy was admitted to our hospital after he developed symptoms of depressive state with catatonia after being diagnosed as having MLC with confirmed MLC1 mutation. Read More

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http://dx.doi.org/10.1186/s12888-020-02750-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333431PMC

Hippocampal subfield morphology in monozygotic twins discordant for affective disorders.

Neuropsychopharmacology 2020 Jul 3. Epub 2020 Jul 3.

Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Unipolar and bipolar disorders aggregate in families and have been associated with a reduced gray-matter volume in hippocampal and prefrontal cortex. Here we used structural MRI to clarify whether abnormalities in hippocampal subfield and prefrontal cortical morphology are associated with familial vulnerability (i.e. Read More

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http://dx.doi.org/10.1038/s41386-020-0756-2DOI Listing

Factors associated with 30-day readmissions following medical hospitalizations among Medicaid beneficiaries with schizophrenia, bipolar disorder, and major depressive disorder.

Psychiatry Res 2020 Jun 1;291:113168. Epub 2020 Jun 1.

Department of Psychiatry, Fetter Health Care Network, Charleston, SC, USA.

While evidence suggests that adults with serious mental illness have an elevated rate of 30-day readmissions after medical hospitalizations, most studies are of patients who are privately insured or Medicare beneficiaries, and little is known about the differential experiences of people with schizophrenia, bipolar disorder, and major depression. We used the Truven Health Analytics MarketScan® Medicaid Multi-State Database to study 43,817 Medicaid enrollees from 11 states, age 18-64, who were discharged from medical hospitalizations in 2011. Our outcome was unplanned all-cause readmissions within 30 days of discharge. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113168DOI Listing

Clinical impact of antipsychotic and benzodiazepine reduction: findings from a multicomponent psychotropic reduction program within long-term aged care.

Int Psychogeriatr 2020 Jun 18:1-13. Epub 2020 Jun 18.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.

Objectives: To explore the relationships between dose changes to antipsychotic and/or benzodiazepine medications and resident outcomes, including variations in neuropsychiatric symptoms, quality of life (QoL), and social withdrawal, within a multicomponent, interdisciplinary antipsychotic and benzodiazepine dose reduction program.

Design: Prospective, observational, longitudinal study.

Intervention: The Reducing Use of Sedatives (RedUSe) project involved 150 Australian Long-Term Care Facilities (LTCFs) incorporating auditing and benchmarking of prescribing, education, and multidisciplinary sedative reviews. Read More

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http://dx.doi.org/10.1017/S1041610220000940DOI Listing

The experience of patients with bipolar disorder from diagnosis disclosure: A qualitative study.

Med J Islam Repub Iran 2020 20;34:36. Epub 2020 Apr 20.

Mental Health Research Center, Tehran Institute of Psychiatry- School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran.

Disclosure of the diagnosis is an essential part of the treatment process and an important part of patient rights. However, it can be a very stressful experience, especially in mental health disorders. Patients with bipolar disorder have a unique experience of receiving and managing their diagnosis. Read More

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http://dx.doi.org/10.34171/mjiri.34.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320983PMC

The antidepressant efficacy of the muscarinic antagonist scopolamine: Past findings and future directions.

Adv Pharmacol 2020 18;89:357-386. Epub 2020 Jun 18.

Janssen R&D, LLC, Neuroscience Therapeutic Area, San Diego, CA, United States. Electronic address:

Scopolamine is a nonselective muscarinic antagonist that has shown relatively rapid antidepressant effects, although to date the results are from limited clinical studies. Scopolamine reportedly has downstream signaling effects thought to be linked to neuroplasticity within glutamatergic synapses and consequent antidepressant action. In psychiatry, clinically validated pathways are unusual and thus merit further research in an effort develop more effect medicines for patients with mood disorders. Read More

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http://dx.doi.org/10.1016/bs.apha.2020.04.002DOI Listing

Effects of psychotherapy on comorbid bipolar disorder and substance use disorder: a systematic review.

Bipolar Disord 2020 Jul 2. Epub 2020 Jul 2.

Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.

Objectives: This review aim is to examinewhether psychotherapy is more or less effective in patients with SUD, compared to those without;whether there is a differential effect of a particular psychotherapy in patients with SUD METHODS: A quantitative systematic review following the Cochrane Handbook of Systematic Reviews was used.

Results: Five studies of psychotherapy for BD and two studies of an integrated psychotherapy for comorbid BD and SUD were included in the review. Five studies provided a sub-analysis of the effect of SUD on overall outcomes with only one finding an overall detrimental effect. Read More

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http://dx.doi.org/10.1111/bdi.12971DOI Listing

A Preliminary Study of the Effects of Treatment with Lithium Versus Quetiapine on Attention of Adolescents with Bipolar Disorder.

J Child Adolesc Psychopharmacol 2020 Jun 30. Epub 2020 Jun 30.

Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Despite attentional deficits being a prominent feature of bipolar disorder, there are limited data on the effects of common treatments for bipolar disorder on attention. Thus, we sought to compare the effects of lithium versus quetiapine on attention in adolescents with bipolar disorder. Adolescents ages 10-17 with bipolar disorder, type I, who were experiencing a manic or mixed episode, were recruited from outpatient settings and the inpatient psychiatric units at Cincinnati Children's Hospital Medical Center during their first manic episode. Read More

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http://dx.doi.org/10.1089/cap.2019.0169DOI Listing

Patient-level Characteristics and Inequitable Access to Inpatient Electroconvulsive Therapy for Depression: A Population-based Cross-sectional Study: Caractéristiques au niveau du patient et accès inéquitable à la thérapie électroconvulsive pour patients hospitalisés.

Can J Psychiatry 2020 Jul 2:706743720935647. Epub 2020 Jul 2.

Department of Psychiatry, University of Toronto, Ontario, Canada.

Objective: A variety of patient characteristics drive the use of electroconvulsive therapy (ECT) in depression. However, the extent to which each characteristic influences the receipt of ECT, and whether they are appropriate, is unknown. The aim of this study is to identify patient-level characteristics associated with receiving inpatient ECT for depression. Read More

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http://dx.doi.org/10.1177/0706743720935647DOI Listing