57,522 results match your criteria Bipolar Affective Disorder

Trauma exposure and co-occurring ICD-11 post-traumatic stress disorder and complex post-traumatic stress disorder in adults with lived experience of psychiatric disorder.

Acta Psychiatr Scand 2022 Jun 26. Epub 2022 Jun 26.

National Centre for Mental Health, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, Wales.

Objective: To establish factors associated with ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD) in a large sample of adults with lived experience of psychiatric disorder and examine the psychiatric burden associated with the two disorders.

Methods: 1305 adults were recruited from the National Centre for Mental Health (NCMH) cohort. ICD-11 PTSD/CPTSD were assessed with the International Trauma Questionnaire (ITQ). Read More

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Aging in bipolar disorder: Cognitive performance and clinical factors based on an adulthood-lifespan perspective.

J Affect Disord 2022 Jun 22. Epub 2022 Jun 22.

Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain.

Background: The evolution of cognitive performance throughout the lifespan in bipolar disorder (BD) is understudied. This cross-sectional study aims to describe the cognitive performance across age groups.

Methods: A sample of 654 participants was recruited for this study (BD = 432 and healthy controls -HC- =222). Read More

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Mental health during the COVID-19 pandemic, impact of childhood trauma in psychiatric disorders, and predictable biomarkers for bipolar disorder.

Kenji Hashimoto

Eur Arch Psychiatry Clin Neurosci 2022 Jun 25. Epub 2022 Jun 25.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

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Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life.

Braz J Psychiatry 2022 Jun 24. Epub 2022 Jun 24.

Departamento de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

Objective: : Maternal attention-deficit/hyperactivity disorder has not been investigated in relation to parenting skills in adolescent mothers. This study investigated whether maternal inattention and hyperactivity/impulsivity symptoms early in pregnancy predict poorer parenting skills and infant maltreatment during the first year of life in adolescent mothers living in adverse environmental conditions.

Methods: : The participants in this study were 80 adolescent mothers aged 14-19 years and their babies who were taking part in a randomized controlled trial on the effects of a home-visiting program on infant development. Read More

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Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients.

Braz J Psychiatry 2022 Jun 24. Epub 2022 Jun 24.

Department of Nutrition and Dietetics, Gaziantep University Faculty of Health Science, Gaziantep, Turkey.

Objective: Bipolar I disorder (BD-I) is a type of bipolar spectrum disorder characterized by manic or mixed episodes. Detecting microRNA regulations as epigenetic actors in BD-I is important to elucidate the pathogenesis of the disease and reveal the potential of microRNAs (miRNAs) as biomarkers.

Methods: We evaluated the expression profile of six candidate miRNAs (hsa-miR-145-5p, hsa-miR376a-3p, hsa-miR-3680-5p, hsa-miR-4253-5p, hsa-miR-4482-3p, and hsa-miR-4725) in patients with BD-I and in healthy controls (aged 11-50 years). Read More

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Familial Brain Calcifications With Leukoencephalopathy: A Novel Variant.

Neurol Genet 2022 Aug 20;8(4):e200001. Epub 2022 May 20.

Department of Neurology and Rehabilitation Medicine (J.S., A.J.E., E.J.H.), University of Cincinnati; and Department of Human Genetics (A.S.), Cincinnati Children's Hospital Medical Center, OH.

Objective: To describe a family with primary familial brain calcifications (PFBCs) and leukoencephalopathy associated with a novel variant in .

Methods: We present 3 generations of a family with PFBC associated with a previously unreported variant in .

Results: A 24-year-old woman with migraine, bipolar disorder, and functional neurologic disorder was found to have bilateral calcifications of the basal ganglia and frontally predominant periventricular white matter disease. Read More

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Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis.

Microorganisms 2022 May 29;10(6). Epub 2022 May 29.

Second Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.

There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota-gut-brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Read More

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White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder.

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Diffusion Magnetic Resonance Imaging (dMRI) studies have reported abnormalities in emotion regulation circuits in BD; however, no study has examined the contribution of previous illness on these mechanisms. Using global probabilistic tractography, we aimed to identify neural correlates of previous BD illness and the extent to which these can help predict one-year recurrence of depressive episodes. dMRI data were collected in 70 adults with early-onset BD who were clinically followed for up to 18 years and 39 healthy controls. Read More

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Circulating miRNAs as Potential Biomarkers for Patient Stratification in Bipolar Disorder: A Combined Review and Data Mining Approach.

Genes (Basel) 2022 Jun 10;13(6). Epub 2022 Jun 10.

Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.

Bipolar disorder is a debilitating psychiatric condition that is shaped in a concerted interplay between hereditary and triggering risk factors. Profound depression and mania define the disorder, but high clinical heterogeneity among patients complicates diagnosis as well as pharmacological intervention. Identification of peripheral biomarkers that capture the genomic response to the exposome may thus progress the development of personalized treatment. Read More

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No Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders: A Retrospective Study.

Brain Sci 2022 Jun 19;12(6). Epub 2022 Jun 19.

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Italy.

Background: We investigated, for the first time, whether there are any sex differences in retrospective self-reported childhood maltreatment (CM) in Italian adult patients with major depressive disorder (MDD) or bipolar disorder (BD). Furthermore, the potential impacts of patients' age on the CM self-report were investigated.

Methods: This retrospective study used the data documented in the electronic medical records of patients who were hospitalized for a 4-week psychiatric rehabilitation program. Read More

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Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations.

Biomolecules 2022 Jun 20;12(6). Epub 2022 Jun 20.

Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.

In 2002, the novel human gene G72 was associated with schizophrenia susceptibility. This gene encodes a small protein of 153 amino acids, named pLG72, which represents a rare case of primate-specific protein. In particular, the rs2391191 single nucleotide polymorphism (resulting in in the R30K substitution) was robustly associated to schizophrenia and bipolar disorder. Read More

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Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis.

Biomedicines 2022 Jun 9;10(6). Epub 2022 Jun 9.

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain.

Bipolar disorder (BD) is a multifactorial chronic psychiatric disease highly defined by genetic, clinical, environmental and social risk factors. The present systematic review and meta-analysis aimed to examine the relationship between inflammatory and neurotrophic factors and clinical, social and environmental factors involved in the development and the characterization of BD. Web of Science, PubMed, PsycINFO, Scopus and Science Direct were searched by two independent reviewers. Read More

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Mechanisms Underlying Antipsychotic-Induced NAFLD and Iron Dysregulation: A Multi-Omic Approach.

Biomedicines 2022 May 24;10(6). Epub 2022 May 24.

Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA.

Atypical antipsychotic (AA) medications are widely prescribed for the treatment of psychiatric disorders, including schizophrenia, bipolar disorder and treatment-resistant depression. AA are associated with myriad metabolic and endocrine side effects, including systemic inflammation, weight gain, dyslipidemia and insulin resistance, all of which are associated with increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is highly prevalent in patients with mental illness, and AA have been shown to increase incidence of NAFLD pre-clinically and clinically. Read More

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Euthymic patients with predominantly manic polarity avoid happy faces in a dot probe task.

Int J Bipolar Disord 2022 Jun 23;10(1):16. Epub 2022 Jun 23.

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt, Germany.

Background: Some studies suggest a mood-congruent attentional bias in bipolar patients. However, for euthymic patients, especially in dependence on the predominant polarity, there is little and inconsistent data. A clearer understanding of emotion-related attentional biases and their relationship to dysfunctional emotion regulation could help improving the diagnostics and treatment of bipolar disorder (BD). Read More

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Structural elucidation of two novel degradants of lurasidone and their formation mechanisms under free radical-mediated oxidative and photolytic conditions via liquid chromatography-photodiode array/ultraviolet-tandem mass spectrometry and one-dimensional/two-dimensional nuclear magnetic resonance spectroscopy.

J Mass Spectrom 2022 Jul;57(7):e4871

Center of Excellence for Modern Analytical Technologies (CEMAT), Huahai Pharmaceutical Co., Ltd., Linhai, Zhejiang, China.

Lurasidone is an antipsychotic drug clinically used for the treatment of schizophrenia and bipolar disorder. During a mechanism-based forced degradation study of lurasidone, two novel degradation products were observed under free radical-mediated oxidative (via AIBN) and solution photolytic conditions. The structures of the two novel degradants were identified through an approach combining HPLC, LC-MS (n = 1, 2), preparative HPLC purification and NMR spectroscopy. Read More

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REM-Sleep Deprivation Induces Mitochondrial Biogenesis in the Rat Hippocampus.

In Vivo 2022 Jul-Aug;36(4):1726-1733

Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea

Background/aim: Sleep loss is proposed as a trigger for manic episodes in bipolar disorder in humans. It has been shown that sleep and wakefulness can affect changes in mitochondrial gene expression, oxidative phosphorylation (OXPHOS) activity, and morphology in the brain. In this study, we investigated alterations in mitochondrial bioenergetic function in the brain of rats after 72-h rapid eye movement sleep deprivation (REM-SD). Read More

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A Systematic Review and Meta-Analysis of Metabolic Syndrome Prevalence in Chinese Inpatients with Bipolar Disorder.

Horm Metab Res 2022 Jun 23. Epub 2022 Jun 23.

psychiatry, Zhejiang Chinese Medical University, Hangzhou, China.

To study prevalence of metabolic syndrome in Chinese patients with bipolar disorder. We searched Chinese literature related to the study in prevalence of metabolic syndrome in bipolar disorder in Chinese language,among which results such as comments, letters, reviews and case reports were excluded. The prevalence of metabolic syndrome in bipolar disorder was synthesized and discussed. Read More

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Natural Language Processing and Psychosis: On the Need for Comprehensive Psychometric Evaluation.

Schizophr Bull 2022 Jun 23. Epub 2022 Jun 23.

University of Georgia, Department of Psychology, Athens, GA, USA.

Background And Hypothesis: Despite decades of "proof of concept" findings supporting the use of Natural Language Processing (NLP) in psychosis research, clinical implementation has been slow. One obstacle reflects the lack of comprehensive psychometric evaluation of these measures. There is overwhelming evidence that criterion and content validity can be achieved for many purposes, particularly using machine learning procedures. Read More

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Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania: a randomized, double-blind and placebo-controlled trial.

Psychiatry Clin Neurosci 2022 Jun 23. Epub 2022 Jun 23.

Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Aim: Palmitoylethanolamide (PEA) is an endogenous fatty acid amide with neuroprotective and anti-inflammatory actions. This is a randomized, double-blind, placebo-controlled clinical trial to investigate the efficacy and safety of PEA combination therapy in acute mania.

Methods: Patients in acute phase of mania were assigned into two parallel groups given either lithium (blood level of 0. Read More

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COVID-19 ethnic inequalities in mental health and multimorbidities: protocol for the COVEIMM study.

Soc Psychiatry Psychiatr Epidemiol 2022 Jun 23. Epub 2022 Jun 23.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.

Purpose: The COVID-19 pandemic may have exacerbated ethnic health inequalities, particularly in people with multiple long-term health conditions, the interplay with mental health is unclear. This study investigates the impact of the pandemic on the association of ethnicity and multimorbidity with mortality/service use among adults, in people living with severe mental illnesses (SMI).

Methods: This study will utilise secondary mental healthcare records via the Clinical Record Interactive Search (CRIS) and nationally representative primary care records through the Clinical Practice Interactive Research Database (CPRD). Read More

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Carbamazepine Overdose after Psychiatric Conditions: A Case Study for Postmortem Analysis in Human Bone.

Toxics 2022 Jun 13;10(6). Epub 2022 Jun 13.

Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, 30120 Murcia, Spain.

Carbamazepine is the main option used as a preventive medication to treat bipolar disorder when there is no response to lithium. Carbamazepine toxicity is defined as serum levels greater than 12 μg/mL, with severe toxicity occurring over 40 μg/mL, reduced to 30 μg/mL when combined with pharmacological treatment, i.e. Read More

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Cardiac Morbidity and Mortality Associated with the Use of Lamotrigine.

Epilepsia 2022 Jun 23. Epub 2022 Jun 23.

National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark.

Objective: The US Food and Drug Administration recently issued a warning against the use of the antiseizure medication lamotrigine in people at risk of cardiac rhythm and conduction abnormalities. This study assessed the risk of cardiac morbidity and mortality in new users of lamotrigine.

Methods: In a Danish population-based cohort study, we followed cohort members aged ≥15 years for the first two years after they initiated lamotrigine therapy. Read More

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Social behavior and spatial orientation in rat strains with genetic predisposition to catatonia (GC) and stereotypes (PM).

Vavilovskii Zhurnal Genet Selektsii 2022 May;26(3):281-289

Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Various psychopathologies, including schizophrenia, bipolar disorder and major depression, are associated with abnormalities in social behavior and learning. One of the syndromes that may also take place in these disorders is catatonia. Catatonia is a psychomotor syndrome in which motor excitement, stereotypy, stuporous state, including the phenomenon of "waxy flexibility" (catalepsy), can be observed. Read More

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A Missing Link in Affect Regulation: The Cerebellum.

Soc Cogn Affect Neurosci 2022 Jun 22. Epub 2022 Jun 22.

Temple University, Philadelphia, PA 19122, USA.

The cerebellum is one third the size of the cerebrum yet holds twice the number of neurons. Historically, its sole function was thought to be in the calibration of smooth movements through the creation and ongoing modification of motor programs. This traditional viewpoint has been challenged by findings showing that cerebellar damage can lead to striking changes in non-motor behavior, including emotional changes. Read More

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Evolution of first episode psychosis diagnoses and health service use among young Māori and non-Māori-A New Zealand national cohort study.

Early Interv Psychiatry 2022 Jun 22. Epub 2022 Jun 22.

Department of Māori/Indigenous Health Innovation (MIHI), University of Otago Christchurch, Christchurch, New Zealand.

Aims: The validity of diagnostic classification in early psychosis has important implications for early intervention; however, it is unknown if previously found disparities between Māori (Indigenous people of New Zealand) and non-Māori in first episode diagnoses persist over time, or how these differences impact service use.

Methods: We used anonymized routine mental health service data and a previously established cohort of over 2400 13-25-year-old youth diagnosed with FEP between 2009 and 2012, to explore differences in diagnostic stability of psychosis diagnoses, comorbid (non-psychosis) diagnoses, and mental health service contacts between Māori and non-Māori in the five-year period following diagnosis.

Results: Differences in schizophrenia and affective psychosis diagnoses between Māori and non-Māori were maintained in the five-year period, with Māori being more likely to be diagnosed with schizophrenia (51% vs. Read More

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A systematic review comparing caregiver burden and psychological functioning in caregivers of individuals with schizophrenia spectrum disorders and bipolar disorders.

BMC Psychiatry 2022 Jun 23;22(1):422. Epub 2022 Jun 23.

Orygen, 35 Poplar Road, Melbourne, Victoria, 3052, Australia.

Background: Informal primary caregivers provide crucial supports to loved ones experiencing serious mental illnesses with profound outcomes for the caregivers themselves. A comprehensive understanding of how different serious mental illnesses change the caregiving experience may provide important insight into the ways in which caregivers can be better supported in their role. The aim of this review was to synthesize the comparative literature examining caregiver burden and psychological functioning (anxiety, depression, distress, and psychological wellbeing) between caregivers of people with schizophrenia spectrum disorders and bipolar disorder. Read More

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Mental Health Conditions and Severe COVID-19 Outcomes after Hospitalization, United States.

Emerg Infect Dis 2022 Jul;28(7):1533-1536

Among 664,956 hospitalized COVID-19 patients during March 2020-July 2021 in the United States, select mental health conditions (i.e., anxiety, depression, bipolar, schizophrenia) were associated with increased risk for same-hospital readmission and longer length of stay. Read More

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Sex differences in fronto-limbic white matter tracts in youth with mood disorders.

Psychiatry Clin Neurosci 2022 Jun 22. Epub 2022 Jun 22.

Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, Queensland, 4575, Australia.

Aims: Depression and bipolar disorder patients have previously been shown to have impaired white matter (WM) integrity compared to healthy controls. This study aimed to investigate potential sex differences that may provide further insight into the pathophysiology of these highly debilitating mood disorders.

Methods: Participants (17-30 years of age), N=168 depression (60% females) and N=107 bipolar disorder (74% females) and N=61 controls (64% females), completed clinical assessment, self-report measures and a neuropsychological assessment battery. Read More

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