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Biotechnology reports Amsterdam Netherl... Publications | PubFacts

375,351 results match your criteria Biotechnology reports Amsterdam Netherlands[Journal]


Different response of bacteria, archaea and fungi to process parameters in nine full-scale anaerobic digesters.

Microb Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Microbiology and Biotechnology, Ulm University, Ulm, Germany.

Biogas production is a biotechnological process realized by complex bacterial, archaeal and likely fungal communities. Their composition was assessed in nine full-scale biogas plants with distinctly differing feedstock input and process parameters. This study investigated the actually active microbial community members by using a comprehensive sequencing approach based on ribosomal 16S and 28S rRNA fragments. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-7915.13
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http://dx.doi.org/10.1111/1751-7915.13409DOI Listing
April 2019
1 Read

IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population.

Chemotherapy 2019 Apr 17:1-8. Epub 2019 Apr 17.

Department of Radiotherapy, Shaanxi Provincial Cancer Hospital Affiliated to Medical College, Xi'an Jiaotong University, Xi'an, China,

Background: Recent evidence suggested that IL1RN (interleukin-1 receptor antagonist) polymorphisms increased the susceptibility to cancers. The present study aimed to evaluate whether IL1RN was related to esophageal cancer susceptibility in a Northwest Han Chinese population.

Methods: The case-control study was conducted on 384 esophageal cancer patients and 499 healthy controls. Read More

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http://dx.doi.org/10.1159/000496400DOI Listing

Elastic properties and intrinsic strength of two-dimensional InSe flakes.

Nanotechnology 2019 Apr 17. Epub 2019 Apr 17.

University of Washington, Seattle, Washington, UNITED STATES.

Mechanical property of two-dimensional (2D) materials is critical for their applications in functional devices as well as for strain engineering. Here, we report the Young's modulus and breaking strength of multilayered InSe, an emerging 2D semiconductors of layered group III chalcogenide. Few-layer InSe flaks were exfoliated from bulk InSe crystal onto Si/SiO2 substrate with micro-fabricated holes, and indentation tests were carried using an Atomic Force Microscopy (AFM) probe. Read More

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http://iopscience.iop.org/article/10.1088/1361-6528/ab1a96
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http://dx.doi.org/10.1088/1361-6528/ab1a96DOI Listing
April 2019
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Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review.

Eur J Med Chem 2019 Apr 10;173:117-153. Epub 2019 Apr 10.

School of Chemistry, Chemical Engineering and Life Science, School of Materials Science and Engineering, Wuhan University of Technology, 205 Luoshi Road, Wuhan, 430070, PR China. Electronic address:

At present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.03.063DOI Listing

Four new guaiane sesquiterpenoids from agarwood of Aquilaria filaria.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address:

Six 8,12-epoxyguaiane sesquiterpenes (1-6), together with two known 2-(2-phenylethyl)chromone derivatives (7-8) were isolated from agarwood originating from Aquilaria filaria. Their structures were established by spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR, and comparison with the published data. The absolute configuration of compound 1 was unambiguously determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.007DOI Listing

Further terpenoids from Euphorbia tirucalli.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France. Electronic address:

The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.001DOI Listing

Two alpha-2 macroglobulin from Portunus trituberculatus involved in the prophenoloxidase system, phagocytosis and regulation of antimicrobial peptides.

Fish Shellfish Immunol 2019 Apr 14. Epub 2019 Apr 14.

School of Marine Science, Ningbo University, Zhejiang, Ningbo, 315211, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China. Electronic address:

Alpha-2 macroglobulin (A2M) is a ubiquitous protease inhibitor involved in the innate host defense system. Herein, two distinct A2M genes (designated as PtA2M-1 and PtA2M-2, respectively) were isolated from the swimming crab Portunus trituberculatus. PtA2M-1 and PtA2M-2 encoded proteins with 1541 or 1516 amino acids, respectively, containing the typically functional domains of A2M. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193027
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http://dx.doi.org/10.1016/j.fsi.2019.04.033DOI Listing
April 2019
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Clinical, immunologic, and molecular spectrum of patients with LPS-responsive beige-like anchor protein (LRBA) deficiency: a systematic review.

J Allergy Clin Immunol Pract 2019 Apr 14. Epub 2019 Apr 14.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

Background: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency and immune dysregulation syndrome caused by biallelic mutations in the LRBA gene. These mutations usually abrogate the protein expression of LRBA, leading to a broad spectrum of clinical phenotypes including autoimmunity, chronic diarrhea, hypogammaglobulinemia and recurrent infections.

Objective: Our aim was to systematically collect all studies reporting on the clinical manifestations, molecular and laboratory findings, and management of patients with LRBA deficiency. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.011DOI Listing

Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ aggregation.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50 - 50134, Florence, Italy; Interuniversity Center for the Study of Neurodegenerative Diseases (CIMN), Florence, Italy. Electronic address:

Oleuropein aglycone (OleA), the most abundant polyphenol in extra virgin olive oil (EVOO), and Hydroxythyrosol (HT), the OleA main metabolite, have attracted our interest due to their multitarget effects, including the interference with amyloid aggregation path. However, the mechanistic details of their anti-amyloid effect are not known yet. We report here a broad biophysical approach and cell biology techniques that enabled us to characterize the different molecular mechanisms by which OleA and HT modulate the Aβ fibrillation, a main histopathological feature of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.015DOI Listing

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

Cell Rep 2019 Apr;27(3):835-846.e5

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. Electronic address:

Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193042
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http://dx.doi.org/10.1016/j.celrep.2019.03.082DOI Listing
April 2019
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Phages Mediate Bacterial Self-Recognition.

Cell Rep 2019 Apr;27(3):737-749.e4

Department of Chemical Engineering, Pennsylvania State University, University Park, PA 16802-4400, USA. Electronic address:

Cells are social, and self-recognition is a conserved aspect of group behavior where cells assist kin and antagonize non-kin. However, the role of phage in self-recognition is unexplored. Here we find that a demarcation line is formed between different swimming Escherichia coli strains but not between identical clones; hence, motile cells discriminate between self and non-self. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.070DOI Listing

Crystal Structure and Directed Evolution of Specificity of NlaIV Restriction Endonuclease.

J Mol Biol 2019 Apr 14. Epub 2019 Apr 14.

International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland. Electronic address:

Specificity engineering is challenging, and particularly difficult for enzymes that have the catalytic machinery and specificity determinants in close proximity. Restriction endonucleases have been used as a paradigm for protein engineering, but successful cases are rare. Here, we present the results of a directed evolution approach to the engineering of a dimeric, blunt end cutting restriction enzyme NlaIV (GGN/NCC). Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.010DOI Listing

Control of Wheat Fusarium Head Blight by Heat-Stable Antifungal Factor (HSAF) from .

Plant Dis 2019 Apr 17:PDIS09181517RE. Epub 2019 Apr 17.

1 Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Jiangsu Key Laboratory for Food Quality and Safety, State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing 210014, P.R. China.

Heat-stable antifungal factor (HSAF), which belongs to the polycyclic tetramate macrolactam family, was isolated from fermentations and exhibited inhibitory activities against a wide range of fungal pathogens. In this study, the antifungal activity of HSAF against in vitro and in vivo was investigated. A total of 50% of mycelial growth of was suppressed with 4. Read More

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http://dx.doi.org/10.1094/PDIS-09-18-1517-REDOI Listing

Detection of serum and salivary IgE and IgG1 immunoglobulins specific for diagnosis of food allergy.

PLoS One 2019 17;14(4):e0214745. Epub 2019 Apr 17.

Laboratory of Biotechnology and Molecular Biology, State University of Ceará, Fortaleza, Ceará, Brazil.

Given the growing incidence and prevalence of life-threatening food allergies, health concerns have raised new perspectives for in vivo and in vitro diagnostic methodologies, pointing to saliva as a promising material, already used to diagnose other pathologies. Based on the above considerations, this study aimed to verify the possible use of saliva for the detection of IgE and IgG1 in the diagnosis of food allergy. This was a randomized, cross-sectional clinical study with a quantitative approach, developed at a hospital referral center in allergy in the state of Ceará, from January to July 2015. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214745PLOS

REEP3 and REEP4 determine the tubular morphology of the endoplasmic reticulum during mitosis.

Mol Biol Cell 2019 Apr 17:mbcE18110698. Epub 2019 Apr 17.

Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.

The endoplasmic reticulum (ER) is extensively remodeled during metazoan open mitosis. However, whether the ER becomes more tubular or more cisternal during mitosis is controversial, and dedicated factors governing the morphology of the mitotic ER have remained elusive. Here, we describe the ER membrane proteins REEP3 and REEP4 as major determinants of ER morphology in metaphase cells. Read More

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https://www.molbiolcell.org/doi/10.1091/mbc.E18-11-0698
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http://dx.doi.org/10.1091/mbc.E18-11-0698DOI Listing
April 2019
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Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

Murdoch Childrens Research Institute, 34361, Neonatal Research, Parkville, Victoria, Australia.

To characterize time-dependent and regionally-specific injury patterns associated with early ventilation of the preterm lung using a mass-spectrometry based proteomic approach. Preterm lambs delivered at gestational age 124-127d were randomized to receive 15-min (n=7) or 90-min (n=10) of mechanical ventilation at standardized settings (positive end-expiratory pressure 8 cmHO, tidal volume 6-8 mL/kg) and were compared with unventilated control lambs (n=7). At study completion, lung tissue was taken from standardized gravity-dependent and non-dependent regions, and assessed for lung injury via histology, qPCR and by proteomic analysis via Orbitrap-mass spectrometry. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2019-0084OC
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http://dx.doi.org/10.1165/rcmb.2019-0084OCDOI Listing
April 2019
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Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues.

Org Lett 2019 Apr 17. Epub 2019 Apr 17.

Division of Biotechnology , Dalian Institute of Chemical Physics , CAS, Dalian 116023 , China.

An Escherichia coli strain was constructed for the efficient import of nicotinamide adenine dinucleotide (NAD) analogues into cells by limiting extracellular degradation while expressing an efficient NAD importer. In vivo functions of three NAD analogues were characterized. Nicotinamide hypoxanthine dinucleotide was identified as an inhibitor of NAD synthesis. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00935DOI Listing

Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404).

J Nat Prod 2019 Apr 17. Epub 2019 Apr 17.

Graduate School of Pharmaceutical Sciences , Kumamoto University , 5-1 Oe-honmachi , Kumamoto 862-0973 , Japan.

Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b01032DOI Listing

Production of l-Ribulose Using an Encapsulated l-Arabinose Isomerase in Yeast Spores.

J Agric Food Chem 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology , Jiangnan University , Wuxi , Jiangsu 214122 , People's Republic of China.

The rare sugar l-ribulose is produced from the abundant sugar l-arabinose by enzymatic conversion. An l-arabinose isomerase (AI) from Geobacillus thermodenitrificans was efficiently expressed and encapsulated in Saccharomyces cerevisiae spores. Deletion of the yeast OSW2 gene, which causes a mild defect in the integrity of the spore wall, substantially improved the activity of encapsulated AI, without damaging its superior enzymatic properties of thermostability, pH tolerance,and resistance toward SDS and proteinase treatments. Read More

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http://pubs.acs.org/doi/10.1021/acs.jafc.9b00640
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http://dx.doi.org/10.1021/acs.jafc.9b00640DOI Listing
April 2019
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Radiosynthesis, radiochemical, and biological characterization of Lu-labeled diethylenetriamine penta-acetic acid.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences, Islamabad, Pakistan.

Diethylenetriamine penta-acetic acid (DTPA), when complexed with a gamma (γ)-emitter radioisotope like Tc, is used for renal function diagnosis and many other diagnostic applications. The main aim of this study was to develop a novel and versatile single-step methodology for the synthesis of a new Lu-labeled radiopharmaceutical with high radiochemical yield, which can be used for diagnostic purposes and therapeutic purposes also. The single and well-defined Lu-DTPA complex was radiochemically characterized by paper chromatography, thin-layer chromatography, high-performance liquid chromatography, and electrophoresis techniques. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28712
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http://dx.doi.org/10.1002/jcb.28712DOI Listing
April 2019
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Extraction and Identification of Anthocyanins in Corn Cob and Corn Husk from Cacahuacintle Maize.

J Food Sci 2019 Apr 17. Epub 2019 Apr 17.

Dept. of Food and Biotechnology, Facultad de Química, Univ. Nacional Autónoma de México., C.P, 04510, Mexico City, Mexico.

Pigmented maize has been extensively studied due to its high anthocyanin content. This study has been focused mainly on kernel, although the whole plant of purple corn is a potential source of anthocyanins. First, general parameters of extraction (solvent system, solvent-to-solid ratio, number of extractions, and acid type) were established depending on the total anthocyanins content. Read More

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http://dx.doi.org/10.1111/1750-3841.14589DOI Listing

Heat stress suppresses Brassica napus seed oil accumulation by inhibition of photosynthesis and BnWRI1 pathway.

Plant Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China.

Heat stress during Brassica napus seed filling severely impairs yield and oil content. However, the mechanisms underlying heat-stress effects on B. napus seed photosynthesis and oil accumulation remain elusive. Read More

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http://dx.doi.org/10.1093/pcp/pcz052DOI Listing

Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.

Food Funct 2019 Apr 17. Epub 2019 Apr 17.

Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, China. and National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China and College of Light Industry and Food Science, Zhongkai University of Agricultural Engineering, Guangzhou 510225, China and Department of Flavor Chemistry, Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart 70599, Germany and College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.

The purpose of this study was to assess the potential effects of polysaccharides from edible mushroom Grifola frondosa (GFP) on lipid metabolic disorders and gut microbiota dysbiosis, and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in high-fat diet (HFD)-exacerbated hyperlipidemic and hypercholesterolemic rats. Results showed that oral administration of GFP markedly alleviated dyslipidaemia through decreasing the serum levels of total triglycerides, total cholesterol, and free fatty acids, and significantly suppressing hepatic lipid accumulation and steatosis. Besides, the excretion of fecal bile acids was also promoted by oral administration of GFP. Read More

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http://dx.doi.org/10.1039/c9fo00075eDOI Listing

Equatorial ligand plane perturbations lead to a spin-state change in an iron(iii) porphyrin dimer.

Dalton Trans 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, India.

A complete reversal of the spin state of iron(iii) is observed upon a small change to the diporphyrin bridge from ethane to ethene by keeping all other factors intact. Combined analysis using single crystal X-ray structure determination, Mössbauer, variable-temperature magnetic, 1H NMR and EPR studies has confirmed the spin states of iron(iii) complexes both in solid and solution phases. Read More

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http://dx.doi.org/10.1039/c9dt01182jDOI Listing

Packaging of DNA origami in viral capsids.

Nanoscale 2019 Apr 17. Epub 2019 Apr 17.

Geza Ad Ltd, Givatayim 53251, Israel.

Here we show the encapsulation of 35 nm diameter, nearly-spherical, DNA origami by self-assembly of SV40-like (simian virus 40) particles. The self-assembly of this new type of nanoparticles is highly reproducible and efficient. The structure of these particles was determined by cryo-EM. Read More

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http://dx.doi.org/10.1039/c8nr10113bDOI Listing

Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders.

Otol Neurotol 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology Head and Neck Surgery, Hannover Medical School, Hannover.

Objective: To provide an overview of biotechnology and pharmaceutical companies active in the field of inner ear and central hearing disorders and their therapeutic approaches.

Methods: Scientific and grey literature was searched using broad search terms to identify companies and their hearing-related therapeutic approaches. For each approach its lead indication, product, therapeutic modality, target, mechanism of action and current phase of clinical development was collated. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002194DOI Listing

Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti.

Parasite 2019 17;26:23. Epub 2019 Apr 17.

Department of Infectious Diseases, National Institute of Health (Istituto Superiore di Sanità, ISS), V.le Regina Elena 299, 00161 Rome, Italy.

Aedes aegypti, the main arbovirus vector of the Yellow fever, Dengue, Chikungunya and Zika viruses, is widely distributed in tropical and subtropical areas throughout the world. Preventive control efforts have been implemented worldwide aimed at reducing its impact on human health. The recent reduction of chemicals available for vector control due to their negative impact on the environment and human health and the increase in mosquito resistance to insecticides have driven the research community to identify and evaluate sustainable alternatives to synthetic insecticides. Read More

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http://dx.doi.org/10.1051/parasite/2019024DOI Listing

Population dynamics at neuraminidase position 151 of influenza A (H1N1)pdm09 virus in clinical specimens.

J Gen Virol 2019 Apr 17. Epub 2019 Apr 17.

3​Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.

Influenza A virus mutates rapidly, allowing it to escape natural and vaccine-induced immunity. Neuraminidase (NA) is a surface protein capable of cleaving the glycosidic linkages of neuraminic acids to release newly formed virions from infected cells. Genetic variants within a viral population can influence the emergence of pandemic viruses as well as drug susceptibility and vaccine effectiveness. Read More

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http://dx.doi.org/10.1099/jgv.0.001258DOI Listing

Gordonia sediminis sp. nov., an actinomycete isolated from mangrove sediment.

Int J Syst Evol Microbiol 2019 Apr 17. Epub 2019 Apr 17.

3​Natural Product Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

The taxonomic position of an actinomycete designated AMA 120, isolated from mangrove sediment, was clarified by phenotypic, chemotaxonomic and phylogenetic studies. The 16S rRNA gene sequence revealed that strain AMA 120 was most closely related to Gordonia rhizosphera NBRC 16068 (98.9 %), Gordonia polyisoprenivorans NBRC 16320 (98. Read More

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http://dx.doi.org/10.1099/ijsem.0.003399DOI Listing

Antimicrobial Effects and Mechanisms of Ethanol Extracts of Seeds Against and Methicillin-Resistant .

Foodborne Pathog Dis 2019 Apr 17. Epub 2019 Apr 17.

4 Department of Food Science, Fu Jen Catholic University, New Taipei City, Taiwan.

seeds contain many bioactive compounds commonly used in traditional Chinese medicine. In this study, the antibacterial activity and possible mechanism of seed ethanol extract (PCEE) against foodborne pathogens were investigated. Both methicillin-resistant (MRSA) and had similar minimum inhibitory concentrations and minimum bactericidal concentrations of PCEE at 50 and 100 μg/mL, respectively. Read More

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http://dx.doi.org/10.1089/fpd.2018.2595DOI Listing

Detection of proteins associated with extracellular matrix regulation in the aqueous humour of patients with primary glaucoma.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a R.S. Mehta Jain Department of Biochemistry and Cell Biology , KBIRVO, Vision Research Foundation, Sankara Nethralaya , Chennai , India .

Purpose: The protein composition of aqueous humour (AH) has held significant relevance and remains to be the prime sample in the discovery of biomarkers in glaucoma. The purpose of this study is to analyze the aqueous humour protein concentrations in primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) and further examine the proteome changes compared to cataract control.

Methods: Aqueous humour was collected from 90 POAG, 72 PACG, 78 cataract (control) in this study. Read More

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http://dx.doi.org/10.1080/02713683.2019.1608261DOI Listing

Altered thalamo–cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studies

J Psychiatry Neurosci 2019 Apr 17;44(3):1-16. Epub 2019 Apr 17.

From the Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden (Gaudio, Olivo, Schiöth); the Centre for Integrated Research, Area of Diagnostic Imaging, Universita Campus Bio-Medico di Roma, Rome, Italy (Gaudio); the Department of Physiology and Pharmacology, Neuroimaging Laboratory, Sapienza University, Rome, Italy (Carducci, Piervincenzi); and the Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia (Schiöth).

Background: Anorexia nervosa and bulimia nervosa are complex mental disorders, and their etiology is still not fully understood. This paper reviews the literature on diffusion tensor imaging studies in patients with anorexia nervosa and bulimia nervosa to explore the usefulness of white matter microstructural analysis in understanding the pathophysiology of eating disorders.

Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify diffusion tensor imaging studies that compared patients with an eating disorder to control groups. Read More

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http://dx.doi.org/10.1503/jpn.180121DOI Listing

[Effects of biochar on soil nutrition and microbial community diversity under continuous cultivated cucumber soils in greenhouse].

Ying Yong Sheng Tai Xue Bao 2019 Apr;30(4):1359-1366

College of Horticulture, Hebei Normal University of Science & Technology, Changli 066600, Hebei, China.

In this study, we examined the effects of biochar addition on the soil nutrition and microbial community diversity in continuous cultivated cucumber soils, using 95% soils of planting cucumbers for 6 and 10 years mixed with 5% biochar as treatment and no biochar addition as control, all plants cultivated in the pots. The results showed that adding biochar increased per plant yield of cucumber by 11.4% and 62. Read More

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http://dx.doi.org/10.13287/j.1001-9332.201904.036DOI Listing

[Effects of Chinese milk vetch intercropped with rape under straw mulching on soil aggregate and organic carbon character].

Ying Yong Sheng Tai Xue Bao 2019 Apr;30(4):1235-1242

College of Agronomy and Biotechnology, Southwest University/Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education/Engineering Research Center of South Upland Agriculture, Ministry of Education, Beibei 400716, Chongqing, China.

There are severe soil erosion, shallow soil, reduction of soil organic matter, and poor soil and water conservation in purple soil areas in Southwest China, which become the main limiting factors for the sustainable development of agriculture. A series of buckets and field experiments in the field were employed to explore the soil aggregate and soil organic carbon in response to Chinese milk vetch intercropped with rape under straw mulching, aiming to improve soil aggregate structure and increase organic carbon content. Results showed that intercropped Chinese milk vetch increased soil micro-aggregate content in rape rhizosphere, and reduced soil aggregate mean mass diameter. Read More

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http://dx.doi.org/10.13287/j.1001-9332.201904.006DOI Listing

Missense changes in the catalytic domain of coagulation factor X account for minimal function preventing a perinatal lethal condition.

Haemophilia 2019 Apr 17. Epub 2019 Apr 17.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

Introduction: Inherited deficiencies in the coagulation pathway provide diversified models to investigate the molecular bases of perinatal lethality associated with null-like variants. Differently from X-linked haemophilias, homozygous/doubly heterozygous null variants in the rare autosomally inherited deficiency of factor X (FX) might be incompatible with perinatal survival.

Aim: To provide experimental evidence about the null/close-to-null FX function. Read More

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http://dx.doi.org/10.1111/hae.13761DOI Listing

CmMYB#7, an R3 MYB transcription factor, acts as a negative regulator of anthocyanin biosynthesis in chrysanthemum.

J Exp Bot 2019 Apr 17. Epub 2019 Apr 17.

College of Agriculture & Biotechnology, Zhejiang University, Zijingang Campus, Hangzhou, PR China.

'Jimba', a well-known white flowered chrysanthemum cultivar, occasionally and spontaneously produces red colored petals under natural cultivation, but there is little information about the molecular regulatory mechanism underlying this process. We analysed the expression patterns of 91 MYB transcription factors in 'Jimba' and 'Turning red Jimba' and identified an R3 MYB, CmMYB#7, whose expression was significantly decreased in 'Turning red Jimba' compared with 'Jimba', and confirmed it is a passive repressor of anthocyanin biosynthesis. CmMYB#7 competed with CmMYB6, which together with CmbHLH2 is an essential component of the anthocyanin activation complex, for interaction with CmbHLH2 through the bHLH binding site in the R3 MYB domain. Read More

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http://dx.doi.org/10.1093/jxb/erz121DOI Listing

Copper-catalyzed ring-opening C(sp)-N coupling of cycloketone oxime esters: access to 1°, 2° and 3° alkyl amines.

Chem Commun (Camb) 2019 Apr 17. Epub 2019 Apr 17.

Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China. and Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

A novel copper-catalyzed C(sp3)-N coupling of cycloketone oxime esters with nitrogen nucleophiles has been realized. All of the N-aryl/alkylanilines, anilines and benzophenone imine could be employed in this protocol to produce a variety of 1°, 2° and 3° alkyl amines in one or two steps. These resultant cyano-containing alkyl amines were proven to be versatile synthetic building blocks in a variety of chemical transformations. Read More

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http://dx.doi.org/10.1039/c9cc02030fDOI Listing

Who Owns the Data in a Medical Information Commons?

J Law Med Ethics 2019 Mar;47(1):62-69

Amy L. McGuire, J.D., Ph.D., is the Leon Jaworski Professor of Biomedical Ethics and Director of the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Dr. McGuire serves on the program committee for the Greenwall Foundation Faculty Scholars Program in Bioethics and is immediate past president of the Association of Bioethics Program Directors. She received a B.A. in psychology from the University of Pennsylvania, a J.D. from the University of Houston, and a Ph.D. from the Institute for Medical Humanities at the University of Texas Medical Branch. Jessica L. Roberts, J.D., is the Alumnae College Professor in Law at the University of Houston Law Center and a past recipient of a Greenwall Faculty Scholar grant. She earned a B.A. in Political Science from the University of Southern California and a J.D. from Yale Law School. Sean Aas, Ph.D., M.A., is a Senior Research Scholar at the Kennedy Institute of Ethics and an Assistant Professor in the Philosophy Department at Georgetown. He is also, presently, a Greenwall Foundation Faculty Scholar. He earned a B.A. and B.S. in Philosophy and Mathematics at The Evergreen State College, a M.A. in Philosophy from Georgia State University, and a Ph.D. in Philosophy from Brown University. Barbara J. Evans, MS, Ph.D., J.D., LL.M., is the Mary Ann and Lawrence E. Faust Professor of Law and Director of the Center for Biotechnology & Law at the University of Houston Law Center and holds a joint appointment as Professor of Electrical and Computer Engineering at the UH Cullen College of Engineering. She holds a B.S.E.E. from the University of Texas at Austin, M.S. and Ph.D. degrees from Stanford University, a J.D. from Yale Law School, and an LL.M. in Health Law from University of Houston.

In this paper, we explore the perspectives of expert stakeholders about who owns data in a medical information commons (MIC) and what rights and interests ought to be recognized when developing a governance structure for an MIC. We then examine the legitimacy of these claims based on legal and ethical analysis and explore an alternative framework for thinking about participants' rights and interests in an MIC. Read More

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http://dx.doi.org/10.1177/1073110519840485DOI Listing

Importance of Participant-Centricity and Trust for a Sustainable Medical Information Commons.

J Law Med Ethics 2019 Mar;47(1):12-20

Amy L. McGuire, J.D., Ph.D., is the Leon Jaworski Professor of Biomedical Ethics and Director of the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Dr. McGuire serves on the program committee for the Greenwall Foundation Faculty Scholars Program in Bioethics and is immediate past president of the Association of Bioethics Program Directors. Mary A. Majumder, J.D., Ph.D., is an Associate Professor of Medicine at the Center for Medical Ethics and Health Policy, Baylor College of Medicine. Angela G. Villanueva, M.P.H., is a Research Associate at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Jessica Bardill, Ph.D., is an Assistant Professor of Indigenous Canadian Literatures and Cultures at Concordia University in Montreal, Quebec. Juli M. Bollinger, M.S., is a Research Associate in the Center for Medical Ethics and Health Policy at the Baylor College of Medicine and a Research Associate and Associate Faculty at the Berman Institute of Bioethics at Johns Hopkins University. Eric Boerwinkle, Ph.D., is the Dean of the University of Texas Health Science Center at Houston, School of Public Health and the Associate Director, Human Genome Sequencing Center at Baylor College of Medicine. Tania Bubela, Ph.D., J.D., is the Dean of the Faculty of Health Sciences at Simon Fraser University and a Fellow of the Canadian Academy of Health Sciences. Patricia Deverka, M.D., M.S., M.B.E., is Director, Value Evidence and Outcomes at Geisinger National Precision Health, where she focuses Outcomes at Geisinger National Precision Health, where she focuses systems and policymakers. Barbara Evans, MS, Ph.D., J.D., LL.M., is the Mary Ann and Lawrence E. Faust Professor of Law and Director of the Center for Biotechnology & Law at the University of Houston Law Center and holds a joint appointment as Professor of Electrical and Computer Engineering at the UH Cullen College of Engineering. Nanibaa' A. Garrison, Ph.D. (Navajo), is an Assistant Professor at the Treuman Katz Center for Pediatric Bioethics at Seattle Children's Hospital and Research Institute and at the Department of Pediatrics at the University of Washington School of Medicine. David Glazer is an engineering director at Verily Life Sciences, where he helps life science organizations use cloud computing to accelerate and scale their work with big data. Melissa M. Goldstein, J.D., is an Associate Professor in the Department of Health Policy and Management at the Milken Institute School of Public Health at the George Washington University. Henry T. Greely, J.D., is the Deane F. and Kate Edelman Johnson Professor of Law and a professor (by courtesy) of Genetics at Stanford University, where he directs the Center for Law and the Biosciences. He is President of the International Neuroethics Society, co-chair of the Neuroethics Work Group of the NIH BRAIN Initiative, and a member of the National Academies' Committee on Science, Technology, and Law. Scott D. Kahn, Ph.D., is the Chief Information Officer at LunaDNA where he is responsible for all informatics and data science strategy. Bartha M. Knoppers, Ph.D., (Comparative Medical Law), is a Full Professor, Canada Research Chair in Law and Medicine and Director of the Centre of Genomics and Policy of the Faculty of Medicine at McGill University. Barbara A. Koenig, Ph.D., is Professor of Bioethics and Medical Anthropology, based at the Institute for Health & Aging, University of California, San Francisco. She also serve as Director of the UCSF Program in Bioethics. J. Mark Lambright, M.B.A., is the Chairman, Trident Advisors, LLC - CEO (Interim), Private Access, Inc. Mark Lambright has been a senior executive of a number of healthcare and technology companies ranging in size from startup to multi-billion in revenue. John Mattison, M.D., is Assistant Medical Director, KP, SCAL, Chief Health Information Officer. Founder of CDA/CCD (XML standard for healthcare interoperability). Co-Editor of Healthcare Information Technology (2017 McGraw Hill). Christopher J. O'Donnell, M.D., M.P.H., is Chief, Cardiology Section and Director, Center for Population Genomics, of the Boston VA Healthcare System and co-Principal Investigator (Chief Scientist) of the national VA Million Veteran Program; and is VA Contact Principal Investigator of the NIH All of Us Research Program. He is also a faculty member of the Department of Medicine, Brigham and Women's Hospital and Associate Professor of Medicine, Harvard Medical School. Arti K. Rai, J.D., is the Elvin R. Latty Professor of Law and co-Director of the Center for Innovation Policy at Duke Law. Laura L. Rodriguez, Ph.D., is the Director of the Division of Policy, Communications, and Education at the National Human Genome Research Institute. Tania Simoncelli, M.S., is the Director of Science Policy at the Chan Zuckerberg Initiative. Formerly Executive Director, Count Me In at the Broad Institute, Assistant Director of Forensic Science and Biomedical Innovation, White House Office of Science & Technology Policy, and Science Advisor to the American Civil Liberties Union. Sharon F. Terry, M.A., is the president and CEO of Genetic Alliance. Adrian Thorogood, B.C.L./LL.B., is a lawyer and Academic Associate at the Centre of Genomics and Policy at McGill University in Montreal, Canada. He manages the Regulatory and Ethics Work Stream of the Global Alliance for Genomics and Health. Michael S. Watson, M.S., Ph.D., is the Executive Director, American College of Medical Genetics and Genomics and ACMG Foundation for Genetic and Genomic Medicine and an Adjunct Professor of Pediatrics at Washington University School of Medicine. John T. Wilbanks is the Chief Commons Officer at Sage Bionetworks, and co-PI on awards for AllofUs Research Program, ELSI Issues in Unregulated Mobile Research, CTSA Center for Data To Health. Robert Cook-Deegan, M.D., is a Professor in the School for the Future of Innovation in Society at Arizona State University.

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons (MIC). Read More

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http://dx.doi.org/10.1177/1073110519840480DOI Listing

Co-infection of peste des petits ruminants and goatpox in a mixed flock of sheep and goats in Kanam, North Central Nigeria.

Vet Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Central Diagnostic Laboratory, National Veterinary Research Institute, Vom, Nigeria.

Peste-des-petits-ruminants (PPR) and Goat pox (GTP) are two devastating and economically important transboundary animal diseases of small ruminants in Africa and Asia that have been difficult to control. This study however, investigated an outbreak of PPR and GTP in a mixed flock of indigenous sheep and goats in Kanam, North Central Nigeria. A total of nine sera and seven tissues (lungs, spleen, scab and skin) samples were collected and analysed in the laboratory using competitive enzyme linked immunosorbent assay (cELISA) for PPR antibodies and polymerase chain reaction (PCR) for detection of PPR virus (PPRV) and GTP virus (GTPV). Read More

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http://dx.doi.org/10.1002/vms3.170DOI Listing

Investigating the diagnostic performance of HOTTIP, PVT1, and UCA1 long noncoding RNAs as a predictive panel for the screening of colorectal cancer patients with lymph node metastasis.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, hahid Beheshti University of Medical Sciences, Tehran, Iran.

Like other noncoding RNAs (ncRNAs), dysregulation of long ncRNAs (lncRNAs) has been associated with various clinicopathological features of colorectal cancer (CRC) patients such as lymph node metastasis (LNM). Recently, three aberrant expressed oncogenic lncRNA (onco-lncRNAs), including HOXA transcript at the distal tip (HOTTIP), plasmacytoma variant translocation 1 (PVT1), and urothelial carcinoma associated 1 (UCA1) have been reported in LNM. Herein, we compared the diagnostic performance of these lncRNAs as individual biomarkers and as a discriminating panel between LNM CRC patients, nonmetastatic lymph nodes (NLN) and normal healthy subjects. Read More

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http://dx.doi.org/10.1002/jcb.28739DOI Listing

Selenium enriched Coriolus versicolor mushroom biomass: potential novel food supplement with improved selenium bioavailability.

J Sci Food Agric 2019 Apr 16. Epub 2019 Apr 16.

University of Belgrade, Faculty of Agriculture, Department of Food and Industrial Microbiology, Belgrade, Serbia.

Background: The ability of Coriolus versicolor medicinal mushroom to accumulate and transform selenium from selenourea and sodium selenite into an organic form L-selenomethionine during growth in liquid medium is examined in this paper. Additionally, the impact of supplementation on biological activity of the selenated mushroom methanol extracts, as well as their chemical composition is studied.

Results: Selenium accumulation was more efficient with sodium selenite application, but biomass yield was significantly lower (1. Read More

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http://dx.doi.org/10.1002/jsfa.9756DOI Listing

A preliminary study of an alternative method for evaluating skin sensitizing potential of chemicals.

Int J Cosmet Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.

The skin, being a barrier between the human body and the environment, is exposed to a series of exogenous chemicals and physical factors. Allergic contact dermatitis (ACD) is one of the most common inflammatory skin diseases that occurs in the general population with a prevalence of 20% [1]. The inflammatory condition is induced by a single or multiple exposure to chemical substances, called haptens, which activate the innate immunity (irritative contact dermatitis) or both innate and acquired immunity (allergic contact dermatitis) [2]. Read More

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http://dx.doi.org/10.1111/ics.12530DOI Listing

Cancer Stem Cells: Acquisition, Characteristics, Therapeutic Implications, Targeting Strategies and Future Prospects.

Stem Cell Rev 2019 Apr 16. Epub 2019 Apr 16.

Amity Institute of Biotechnology, Amity University, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai, Maharashtra, 410206, India.

Since last two decades, the major cancer research has focused on understanding the characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to their ability to initiate tumor growth, self-renewal property and multi-drug resistance. The discovery of the mechanism of acquisition of stem-like properties by carcinoma cells via epithelial-mesenchymal transition (EMT) has paved a way towards a deeper understanding of CSCs and presented a possible avenue for the development of therapeutic strategies. In spite of years of research, various challenges, such as identification of CSC subpopulation, lack of appropriate experimental models, targeting cancer cells and CSCs specifically without harming normal cells, are being faced while dealing with CSCs. Read More

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http://link.springer.com/10.1007/s12015-019-09887-2
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http://dx.doi.org/10.1007/s12015-019-09887-2DOI Listing
April 2019
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Efficacy of mechanical vibration in regulating mesenchymal stem cells gene expression.

In Vitro Cell Dev Biol Anim 2019 Apr 15. Epub 2019 Apr 15.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

This study aimed at investigating the expression of osteoblast and chondrocyte-related genes in mesenchymal stem cells (MSCs), derived from rabbit adipose tissue, under mechanical vibration. The cells were placed securely on a vibrator's platform and subjected to 300 Hz of sinusoidal vibration, with a maximum amplitude of 10 μm, for 45 min per day, and for 14 consequent days, in the absence of biochemical reagents. The negative control group was placed in the conventional culture medium with no mechanical loading. Read More

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http://dx.doi.org/10.1007/s11626-019-00340-9DOI Listing

Analysis of Fatty Acid Esters of Hydroxyl Fatty Acid in Selected Plant Food.

Plant Foods Hum Nutr 2019 Apr 16. Epub 2019 Apr 16.

Division of Molecular Medicine Ruđer Bošković Institute, Zagreb, Croatia.

Metabolic syndrome, characterized by obesity, low-grade inflammation, insulin resistance, hyperglycemia, dyslipidemia and hypertension, is a major risk factor for cardiovascular mortality. Preclinical studies on recently discovered classes of lipids - fatty acid esters of hydroxy fatty acids (FAHFA) have revealed their anti-inflammatory and insulin-sensitizing potential. The FAHFA levels are significantly decreased in insulin-resistant individuals, their application exhibited anti-inflammatory effects and restoring the glucose-insulin homeostasis. Read More

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http://link.springer.com/10.1007/s11130-019-00728-8
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http://dx.doi.org/10.1007/s11130-019-00728-8DOI Listing
April 2019
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PARP-1 inhibition provides protection against elastase-induced emphysema by mitigating the expression of matrix metalloproteinases.

Mol Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Biochemistry, Panjab University, Chandigarh, 160014, India.

In our previous study, we have shown that PARP-1 inhibition (genetic or pharmacological) ameliorates elastase-induced inflammation and emphysema. Since matrix metalloproteinases (MMPs) particularly MMP-2 and MMP-9 are known to play a critical role in emphysema development, the present work was designed to evaluate the effects of PARP-1 inhibition on their expression utilizing elastase-induced mouse model of emphysema. Our data show that olaparib administration at a dose of 5 mg/kg b. Read More

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http://link.springer.com/10.1007/s11010-019-03510-1
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http://dx.doi.org/10.1007/s11010-019-03510-1DOI Listing
April 2019
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Spatio-temporal localization of LlBOP following early events of floral abscission in yellow lupine.

Protoplasma 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, CSIC, 1 Profesor Albareda Street, 18008, Granada, Spain.

The phenomenon of excessive flower abscission in yellow lupine is a process of substantial interest to the agricultural industries, because it substantially affects the yield. The aim of this work was to provide an analysis of the changes taking place precisely in the abscission zone (AZ) during early stages of flower separation. We put particular emphasis on mRNA accumulation of BOP (BLADE ON PETIOLE) gene encoding a transcriptional factor so far considered to be essential for AZ formation. Read More

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http://dx.doi.org/10.1007/s00709-019-01365-3DOI Listing

Interaction of carbohydrate-binding modules with poly(ethylene terephthalate).

Appl Microbiol Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Institute of Molecular Enzyme Technology, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, D-52425, Jülich, Germany.

Poly(ethylene terephthalate) (PET) is one of the most widely applied synthetic polymers, but its hydrophobicity is challenging for many industrial applications. Biotechnological modification of PET surface can be achieved by PET hydrolyzing cutinases. In order to increase the adsorption towards their unnatural substrate, the enzymes are fused to carbohydrate-binding modules (CBMs) leading to enhanced activity. Read More

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http://link.springer.com/10.1007/s00253-019-09760-9
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http://dx.doi.org/10.1007/s00253-019-09760-9DOI Listing
April 2019
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Field study on the factors affecting egg weight loss, early embryonic mortality, hatchability, and chick mortality with the use of classification tree technique.

Poult Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Animal Biotechnology and Genetics, UTP University of Science and Technology, Mazowiecka 28 St., 85-084 Bydgoszcz, Poland.

The aim of this research was to study the factors affecting hatchability, percentage of egg weight loss during incubation, early embryonic mortality, and chick mortality in the first seven days of life in the field. This study was performed on 20,817,600 hatching eggs originating from 7 different breeder flocks. The factors responsible for variability of investigated traits were the following: genotype (ROSS 308, ROSS PM3), hen age (25 to 30, 31 to 45, 46 to 50, and 51 to 60 wk), egg storage time (0 to 13 d), and setter and hatcher type (Digital, Airstreamer, Vision, Focus, Biostreamer), which were determined using the classification tree technique. Read More

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http://dx.doi.org/10.3382/ps/pez180DOI Listing