Secretory expression of negative regulatory region of human Notch1 in E.coli and preparation of a functional polyclonal antibody.
Biotechnol Appl Biochem 2018 Jan 17. Epub 2018 Jan 17.
Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, 650201, China.
Notch signaling is a highly conserved pathway existed in multicellular organisms. It plays roles in normal human body development, human cancer initiation, progression and metastasis. The Notch negative regulatory region (NRR) is critical for Notch signaling, and cleavage at the S2 site in the NRR ultimately leads to the activation of Notch signaling. Read More