Structure-based analysis of Clot as a thioredoxin-related protein of 14 kDa in Drosophila via experimental and computational approaches.
- Kiyoung Kim
Biotechnol Appl Biochem 2017 Oct 28. Epub 2017 Oct 28.
Department of Medical Biotechnology, Soonchunhyang University, Asan, 31538, Korea.
The clot gene is required for the biosynthesis of drosopterins, the red components of Drosophila eye pigments. However, the enzymatic role of Clot in Drosophila eye pigment formation and the molecular mechanisms underlying Clot function are not fully elucidated. In this study, we cloned and characterized Clot derived from Drosophila cDNA, and results showed that Clot exhibited ∼30% sequence identity with mammalian TRP14. Read More