1,763 results match your criteria Biotechnology advances[Journal]


Progress and perspective on cyanobacterial glycogen metabolism engineering.

Biotechnol Adv 2019 Apr 9. Epub 2019 Apr 9.

Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China; Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China; Dalian National Laboratory for Clean Energy, Dalian, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address:

As important oxygenic photoautotrophs, cyanobacteria are also generally considered as one of the most promising microbial chassis for photosynthetic biomanufacturing. Diverse synthetic biology and metabolic engineering approaches have been developed to enable the efficient harnessing of carbon and energy flow toward the synthesis of desired metabolites in cyanobacterial cell factories. Glycogen metabolism works as the most important natural carbon sink mechanism and reserve carbon source, storing a large portion of carbon and energy from the Calvin-Benson-Bassham (CBB) cycle, and thus is traditionally recognized as a promising engineering target to optimize the efficacy of cyanobacterial cell factories. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.005DOI Listing
April 2019
4 Reads

Advances in phytochemical delivery systems for improved anticancer activity.

Biotechnol Adv 2019 Apr 9. Epub 2019 Apr 9.

Lake Erie College of Osteopathic Medicine, 5000 Lakewood Ranch Boulevard, Bradenton, FL 34211, USA. Electronic address:

Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.004DOI Listing
April 2019
11 Reads

Immobilization of lipases on hydrophobic supports: immobilization mechanism, advantages, problems, and solutions.

Biotechnol Adv 2019 Apr 8. Epub 2019 Apr 8.

Departamento de Biocatálisis, ICP-CSIC, Campus UAM-CSIC, Cantoblanco, 28049 Madrid, Spain. Electronic address:

Lipases are the most widely used enzymes in biocatalysis, and the most utilized method for enzyme immobilization is using hydrophobic supports at low ionic strength. This method allows the one step immobilization, purification, stabilization, and hyperactivation of lipases, and that is the main cause of their popularity. This review focuses on these lipase immobilization supports. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.003DOI Listing
April 2019
1 Read

A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products.

Biotechnol Adv 2019 Apr 6. Epub 2019 Apr 6.

Institute of Systems Biotechnology, Saarland University, Campus A1.5, 66123 Saarbrücken, Germany. Electronic address:

Lignin is one of the most abundant renewable resources on earth and is readily produced as a sidestream during biomass fractioning. So far, these large quantities of lignin have been severely underutilized, thereby wasting this valuable renewable. Recent technological advances in lignin recovery, breakdown, and conversion have now started forming the first sustainable value chains to take advantage of lignin. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.016DOI Listing
April 2019
3 Reads

Systems biology based metabolic engineering for non-natural chemicals.

Biotechnol Adv 2019 Apr 4. Epub 2019 Apr 4.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada. Electronic address:

Production of chemicals in microorganisms is no longer restricted to products arising from native metabolic potential. In this review, we highlight the evolution of metabolic engineering studies, from the production of natural chemicals fermented from biomass hydrolysates, to the engineering of microorganisms for the production of non-natural chemicals. Advances in synthetic biology are accelerating the successful development of microbial cell factories to directly produce value-added chemicals. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.001DOI Listing
April 2019
1 Read

Synthetic biology approaches for chromosomal integration of genes and pathways in industrial microbial systems.

Biotechnol Adv 2019 Apr 3. Epub 2019 Apr 3.

Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:

Industrial biotechnology is reliant on native pathway engineering or foreign pathway introduction for efficient biosynthesis of target products. Chromosomal integration, with intrinsic genetic stability, is an indispensable step for reliable expression of homologous or heterologous genes and pathways in large-scale and long-term fermentation. With advances in synthetic biology and CRISPR-based genome editing approaches, a wide variety of novel enabling technologies have been developed for single-step, markerless, multi-locus genomic integration of large biochemical pathways, which significantly facilitate microbial overproduction of chemicals, pharmaceuticals and other value-added biomolecules. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.002DOI Listing
April 2019
9.015 Impact Factor

Enzymatic and cell factory approaches to the production of human milk oligosaccharides.

Biotechnol Adv 2019 Mar 29. Epub 2019 Mar 29.

Laboratory of Biochemistry, Institut Químic de Sarrià, University Ramon Llull, 08017 Barcelona, Spain. Electronic address:

Infant formula milk companies try to develop fortified formula milk that mimics human milk as closely as possible, since it is well-known that breast milk has considerable implications in the development of the infant in the first years of life. Human milk is unique in terms of complex oligosaccharides content, known as human milk oligosaccharides (HMOs). Their role in the development of intestinal flora blocking the attachment of pathogens and modulating the immune system of the infant are currently recognized. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750193005
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http://dx.doi.org/10.1016/j.biotechadv.2019.03.014DOI Listing
March 2019
3 Reads

Glycerol as a substrate for Saccharomyces cerevisiae based bioprocesses - Knowledge gaps regarding the central carbon catabolism of this 'non-fermentable' carbon source.

Biotechnol Adv 2019 Mar 28. Epub 2019 Mar 28.

Department of Life Sciences and Chemistry, Jacobs University gGmbH, Campus Ring 1, Bremen, Germany. Electronic address:

Glycerol is an interesting alternative carbon source in industrial bioprocesses due to its higher degree of reduction per carbon atom compared to sugars. During the last few years, significant progress has been made in improving the well-known industrial platform organism Saccharomyces cerevisiae with regard to its glycerol utilization capability, particularly in synthetic medium. This provided a basis for future metabolic engineering focusing on the production of valuable chemicals from glycerol. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.017DOI Listing

Advances in CRISPR-Cas systems for RNA targeting, tracking and editing.

Biotechnol Adv 2019 Mar 27. Epub 2019 Mar 27.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Brain Center, School of Pharmaceutical Sciences, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei, China; Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China. Electronic address:

Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) systems, especially type II (Cas9) systems, have been widely used in gene/genome targeting. Modifications of Cas9 enable these systems to become platforms for precise DNA manipulations. However, the utilization of CRISPR-Cas systems in RNA targeting remains preliminary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750193005
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http://dx.doi.org/10.1016/j.biotechadv.2019.03.016DOI Listing
March 2019
3 Reads

Sustainability in the biopharmaceutical industry: Seeking a holistic perspective.

Biotechnol Adv 2019 Mar 26. Epub 2019 Mar 26.

Department of Process & Chemical Engineering, University College Cork, Ireland.

Biopharmaceuticals manufacturing is a critical component of the modern healthcare system, with emerging new treatments composed of increasingly complex biomolecules offering solutions to chronic and debilitating disorders. While this sector continues to grow, it strongly exhibits "boom-to-bust" performance which threatens its long-term viability. Future trends within the industry indicate a shift towards continuous production systems using single use technologies that raises sustainability issues, yet research in this area is sparse and lacks consideration of the complex interactions between environmental, social and economic concerns. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.015DOI Listing
March 2019
1 Read

Lignocellulolytic systems of soil bacteria: A vast and diverse toolbox for biotechnological conversion processes.

Biotechnol Adv 2019 Mar 22. Epub 2019 Mar 22.

Laboratory of Environmental Microbiology, Institute of Microbiology of the CAS, Průmyslová 595, Vestec 252 50, Czech Republic. Electronic address:

Lignocellulose from plant biomass represents an abundant and renewable source for the production of environmentally friendly chemicals and biofuels. However, its recalcitrant nature entails the use of complex biochemical reactions that are still challenging. Since the degradation of lignocellulose is the current bottleneck of the conversion processes, the search for novel enzymes and microbial strains for degrading plant biomass is of high importance. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.013DOI Listing
March 2019
1 Read

Neural tissue engineering with structured hydrogels in CNS models and therapies.

Biotechnol Adv 2019 Mar 19. Epub 2019 Mar 19.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom. Electronic address:

The development of techniques to create and use multiphase microstructured hydrogels (granular hydrogels or microgels) has enabled the generation of cultures with more biologically relevant architecture and use of structured hydrogels is especially pertinent to the development of new types of central nervous system (CNS) culture models and therapies. We review material choice and the customisation of hydrogel structure, as well as the use of hydrogels in developmental models. Combining the use of structured hydrogel techniques with developmentally relevant tissue culture approaches will enable the generation of more relevant models and treatments to repair damaged CNS tissue architecture. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.009DOI Listing
March 2019
2 Reads

Production of protein-based polymers in Pichia pastoris.

Biotechnol Adv 2019 Mar 19. Epub 2019 Mar 19.

Wageningen Food & Biobased Research, NL-6708 WG Wageningen, The Netherlands.

Materials science and genetic engineering have joined forces over the last three decades in the development of so-called protein-based polymers. These are proteins, typically with repetitive amino acid sequences, that have such physical properties that they can be used as functional materials. Well-known natural examples are collagen, silk, and elastin, but also artificial sequences have been devised. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.012DOI Listing

New frontiers in agriculture productivity: Optimised microbial inoculants and in situ microbiome engineering.

Biotechnol Adv 2019 Mar 16. Epub 2019 Mar 16.

Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW, Australia; Global Centre for Land-based Innovation, Western Sydney University, Penrith, NSW, Australia. Electronic address:

Increasing agricultural productivity is critical to feed the ever-growing human population. Being linked intimately to plant health, growth and productivity, harnessing the plant microbiome is considered a potentially viable approach for the next green revolution, in an environmentally sustainable way. In recent years, our understanding of drivers, roles, mechanisms, along with knowledge to manipulate the plant microbiome, have significantly advanced. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.010DOI Listing
March 2019
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Emerging strategies for engineering microbial communities.

Biotechnol Adv 2019 Mar 15. Epub 2019 Mar 15.

Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27708, USA. Electronic address:

From biosynthesis to bioremediation, microbes have been engineered to address a variety of biotechnological applications. A promising direction in these endeavors is harnessing the power of designer microbial consortia that consist of multiple populations with well-defined interactions. Consortia can accomplish tasks that are difficult or potentially impossible to achieve using monocultures. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.011DOI Listing
March 2019
2 Reads

Biotechnology of health-promoting bacteria.

Biotechnol Adv 2019 Mar 12. Epub 2019 Mar 12.

Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands. Electronic address:

Over the last decade, there has been an increasing scientific and public interest in bacteria that may positively contribute to human gut health and well-being. This interest is reflected by the ever-increasing number of developed functional food products containing health-promoting bacteria and reaching the market place as well as by the growing revenue and profits of notably bacterial supplements worldwide. Traditionally, the origin of probiotic-marketed bacteria was limited to a rather small number of bacterial species that mostly belong to lactic acid bacteria and bifidobacteria. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.008DOI Listing

Biotin interference in immunoassays based on biotin-strept(avidin) chemistry: An emerging threat.

Biotechnol Adv 2019 Mar 11. Epub 2019 Mar 11.

University College Cork, Irish Separation Science Cluster ISSC Ireland, Innovative Chromatography Group, Western Rd, Cork T12 YN60, Ireland; University College Cork, School of Chemistry, College Road, Cork T12 YN60, Ireland.

Biotinylated antibodies/antigens are currently used in many immunoassay formats in clinical settings for diversified analytes and biomarkers to offer high detection selectivity and sensitivity. Biotin cannot be synthesized by mammals and must be taken as an essential supplement. Normal intake of biotin from various foods and milk causes no effect on the streptavidin/biotin-based immunoassays. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.007DOI Listing
March 2019
4 Reads

Metabolic engineering for the optimization of hydrogen production in Escherichia coli: A review.

Biotechnol Adv 2019 Mar 8. Epub 2019 Mar 8.

Department of Biomedicine, Biotechnology and Public Health-Biochemistry and Molecular Biology, Instituto Universitario de Investigación de Biomoléculas (INBIO), Spain. Electronic address:

Hydrogen is a potential sustainable energy source and it could become an alternative to fossil fuel combustion, thus helping to reduce greenhouse gas emissions. The biological production of hydrogen, instead of its chemical synthesis, is a promising possibility since this process requires less energy and is more sustainable and eco-friendly. Several microorganisms have been used for this purpose, but Escherichia coli is one of the most widely used in this field. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.006DOI Listing

Synthetic biology and metabolic engineering of actinomycetes for natural product discovery.

Biotechnol Adv 2019 Mar 7. Epub 2019 Mar 7.

Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Building 220, 2800 Kgs. Lyngby, Denmark. Electronic address:

Actinomycetes are one of the most valuable sources of natural products with industrial and medicinal importance. After more than half a century of exploitation, it has become increasingly challenging to find novel natural products with useful properties as the same known compounds are often repeatedly re-discovered when using traditional approaches. Modern genome mining approaches have led to the discovery of new biosynthetic gene clusters, thus indicating that actinomycetes still harbor a huge unexploited potential to produce novel natural products. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.005DOI Listing

Corrigendum to "Next generation organoids for biomedical research and applications" [Biotechnology Advances 36 (2018) 132-149].

Biotechnol Adv 2019 May - Jun;37(3):505. Epub 2019 Mar 8.

Yale Stem Cell Center, Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.001DOI Listing

Microbial engineering for easy downstream processing.

Biotechnol Adv 2019 Mar 6. Epub 2019 Mar 6.

Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Department of Chemical Engineering, Tsinghua University, Beijing 100084, China. Electronic address:

Downstream is a very expensive process for microbial fermentation. It usually involves complicated equipment and processes to obtain desired chemicals or materials from intra- or/and extracellular spaces of microorganisms. Recently, it becomes possible to simplify the microbial cell separation processes by morphologically engineering the shapes of small microorganisms. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.004DOI Listing
March 2019
1 Read

Medium chain carboxylic acids production from waste biomass: Current advances and perspectives.

Biotechnol Adv 2019 Mar 5. Epub 2019 Mar 5.

State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, PR China.

Alternative chemicals to diverse fossil-fuel-based products is urgently needed to mitigate the adverse impacts of fossil fuel depletion on human development. To this end, researchers have focused on the production of biochemical from readily available and affordable waste biomass. This is consistent with current guidelines for sustainable development and provides great advantages related to economy and environment. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.003DOI Listing
March 2019
1 Read

Cellulosic ethanol production: Progress, challenges and strategies for solutions.

Biotechnol Adv 2019 May - Jun;37(3):491-504. Epub 2019 Mar 5.

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Science and School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China. Electronic address:

Lignocellulosic biomass is a sustainable feedstock for fuel ethanol production, but it is characterized by low mass and energy densities, and distributed production with relatively small scales is more suitable for cellulosic ethanol, which can better balance cost for the feedstock logistics. Lignocellulosic biomass is recalcitrant to degradation, and pretreatment is needed, but more efficient pretreatment technologies should be developed based on an in-depth understanding of its biosynthesis and regulation for engineering plant cell walls with less recalcitrance. Simultaneous saccharification and co-fermentation has been developed for cellulosic ethanol production, but the concept has been mistakenly defined, since the saccharification and co-fermentation are by no means simultaneous. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750193003
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http://dx.doi.org/10.1016/j.biotechadv.2019.03.002DOI Listing
March 2019
11 Reads
9.015 Impact Factor

Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation.

Biotechnol Adv 2019 Feb 27. Epub 2019 Feb 27.

Fungal Physiology, Westerdijk Fungal Biodiversity Institute & Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. Electronic address:

Fungal strain engineering is commonly used in many areas of biotechnology, including the production of plant biomass degrading enzymes. Its aim varies from the production of specific enzymes to overall increased enzyme production levels and modification of the composition of the enzyme set that is produced by the fungus. Strain engineering involves a diverse range of methodologies, including classical mutagenesis, genetic engineering and genome editing. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.017DOI Listing
February 2019
1 Read

Harmonization of immunoassays for biomarkers in diabetes mellitus.

Biotechnol Adv 2019 Feb 23. Epub 2019 Feb 23.

Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich, University of Tübingen, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.

Harmonization of biomarkers is important for the comparability of laboratory results as it allows the definition of universal reference values and clinical decision limits. In diabetology, immunoassays are widely used to determine HbA1c, C-peptide, insulin, and autoantibodies to beta cell proteins, which are essential biomarkers for the diagnosis and classification of diabetes mellitus. Furthermore, as large clinical studies have identified HbA1c as a predictor for the development of diabetic complications, HbA1c has evolved as the general treatment target. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.015DOI Listing
February 2019
6 Reads
9.015 Impact Factor

Sowing seeds for the future: The need for on-site plant diagnostics.

Biotechnol Adv 2019 Feb 23. Epub 2019 Feb 23.

School of Biotechnology, Dublin City University, Dublin 9, Ireland; Hamad Bin Khalifa University and Research, Development and Innovation, Qatar Foundation, P O Box 5825, Doha, Qatar. Electronic address:

Point-of-care technology is a term used to describe any treatment given at the "site-of-need". The span of point-of-care has broadened, growing from its current dominant usage in clinical settings to encompass many sectors, such as water and food testing. This review focuses on applications of point-of-care/use technology in phytodiagnostics, a field which requires accurate diagnostic systems with increasing urgency due to the demands of global food needs in conjunction with persistent crop loss due to pathogens and increased awareness of the environmental impacts of extensive agrochemical usage. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.014DOI Listing
February 2019
1 Read

Apoptosis: A mammalian cell bioprocessing perspective.

Biotechnol Adv 2019 May - Jun;37(3):459-475. Epub 2019 Feb 20.

Biological Systems Engineering Laboratory, Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom. Electronic address:

Apoptosis is a form of programmed and controlled cell death that accounts for the majority of cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is instigated by several stresses experienced by the cells within a bioreactor. Understanding the factors that cause apoptosis as well as developing strategies that can protect cells is crucial for robust bioprocess development. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.012DOI Listing
February 2019
1 Read

Phycobiliproteins from cyanobacteria: Chemistry and biotechnological applications.

Biotechnol Adv 2019 May - Jun;37(3):422-443. Epub 2019 Feb 21.

CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros de Leixões, Avenida General Norton de Matos s/n, 4450-208 Matosinhos, Portugal; FCUP - Faculty of Science, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal. Electronic address:

Phycobiliproteins are a group of water soluble proteins with an associated chromophore, responsible for the light-harvesting in cyanobacteria. They are divided in four main types: phycoerythrin, phycocyanin, phycoerythrocyanin and allophycocyanin, and they are characterized according to their structure and light quality absorption. Phycobiliproteins from cyanobacteria have been described as potential bioactive compounds, and recognized as high-valued natural products for biotechnological applications. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.010DOI Listing
February 2019
3 Reads

Electroconductive materials as biomimetic platforms for tissue regeneration.

Biotechnol Adv 2019 May - Jun;37(3):444-458. Epub 2019 Feb 20.

Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.. Electronic address:

In many diseases, tissue regeneration is compromised and/or insufficient to restore tissue/organ function. Therefore, novel regenerative therapies are being developed to enhance resident and transplanted cell proliferation and functional differentiation. Numerous biomaterials engineered to include nanocomponents have emerged as promising candidates to fulfil the need of mimicking the properties of the healthy extracellular matrix. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.011DOI Listing
February 2019
1 Read

The fungal cell wall as a target for the development of new antifungal therapies.

Biotechnol Adv 2019 Feb 21. Epub 2019 Feb 21.

Instituto de Biología Funcional y Genómica and Departamento de Microbiología y Genética, Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Salamanca, Salamanca, Spain. Electronic address:

In the past three decades invasive mycoses have globally emerged as a persistent source of healthcare-associated infections. The cell wall surrounding the fungal cell opposes the turgor pressure that otherwise could produce cell lysis. Thus, the cell wall is essential for maintaining fungal cell shape and integrity. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.008DOI Listing
February 2019
3 Reads

A 'culture' shift: Application of molecular techniques for diagnosing polymicrobial infections.

Biotechnol Adv 2019 May - Jun;37(3):476-490. Epub 2019 Feb 20.

Emergency Medicine, Stanford University, Stanford, California 94305, USA. Electronic address:

With the advancement of microbiological discovery, it is evident that many infections, particularly bloodstream infections, are polymicrobial in nature. Consequently, new challenges have emerged in identifying the numerous etiologic organisms in an accurate and timely manner using the current diagnostic standard. Various molecular diagnostic methods have been utilized as an effort to provide a fast and reliable identification in lieu or parallel to the conventional culture-based methods. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447436PMC
February 2019
4 Reads
9.015 Impact Factor

Biomaterializing the promise of cardiac tissue engineering.

Biotechnol Adv 2019 Feb 20. Epub 2019 Feb 20.

Division of Cardiology, Department of Medicine, Duke University Health System, Durham, NC, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. Electronic address:

During an average individual's lifespan, the human heart pumps nearly 200 million liters of blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that native myocardium under this incredible demand is extraordinarily complex, both structurally and functionally. As a result, successful engineering of adult-mimetic functional cardiac tissues is likely to require utilization of highly specialized biomaterials representative of the native extracellular microenvironment. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.009DOI Listing
February 2019

Towards development of electrogenetics using electrochemically active bacteria.

Biotechnol Adv 2019 Feb 16. Epub 2019 Feb 16.

School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Electronic address:

Owing to the ability for efficient electric interaction with electrodes, electrochemically active bacteria (EAB) attract considerable attention in biotechnology. These bacteria are involved not only in the generation of electricity from organic wastes in microbial fuel cells but also in the production of valued chemicals with the aid of electric energy in microbial electrosynthesis systems. It has been known that metabolic activities in EAB are affected by electrode potentials, while a recent work has found that in an EAB, Shewanella oneidensis MR-1, an Arc regulatory system regulates the expression of diverse catabolic genes by sensing electrode potentials. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.007DOI Listing
February 2019
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The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challenges.

Biotechnol Adv 2019 May - Jun;37(3):410-421. Epub 2019 Feb 16.

Nutrition and Food Science Area, Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda.Vicent Andrés Estellés, s/n, 46100, Burjassot, València, Spain. Electronic address:

The recent progress in genetic engineering has brought multiple benefits to the food and agricultural industry by enhancing the essential characteristics of agronomic traits. Powerful tools in the field of genome editing, such as siRNA-mediated RNA interference for targeted suppression of gene expression and transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs) for DNA repair have been widely used for commercial purposes. However, in the last few years, the discovery of the CRISPR-Cas9 system has revolutionized genome editing and has attracted attention as a powerful tool for several industrial applications. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.006DOI Listing
February 2019
3 Reads
9.015 Impact Factor

Engineered microbial host selection for value-added bioproducts from lignocellulose.

Biotechnol Adv 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

Lignocellulose is a rich and sustainable globally available carbon source and is considered a prominent alternative raw material for producing biofuels and valuable chemical compounds. Enzymatic hydrolysis is one of the crucial steps of lignocellulose degradation. Cellulolytic and hemicellulolytic enzyme mixes produced by different microorganisms including filamentous fungi, yeasts and bacteria, are used to degrade the biomass to liberate monosaccharides and other compounds for fermentation or conversion to value-added products. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.003DOI Listing
February 2019

Harnessing the catabolic versatility of Gordonia species for detoxifying pollutants.

Biotechnol Adv 2019 May - Jun;37(3):382-402. Epub 2019 Feb 13.

Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, Pune 411007, India; Department of Microbiology, Savitribai Phule Pune University, Pune 411007, India. Electronic address:

The genus Gordonia includes variedly pigmented aerobic, non-motile, non-sporulating Gram positive (sometimes variable) coccoid forms and rods. Different isolates display distinguishing physiological traits and biochemical properties that are significant in remediation applications. Strains inherently prevalent in soils, seawater, sediments and wastewaters can degrade hydrocarbons. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.004DOI Listing
February 2019
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Advances in 2-phenylethanol production from engineered microorganisms.

Biotechnol Adv 2019 May - Jun;37(3):403-409. Epub 2019 Feb 13.

The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Research Centre of Industrial Microbiology, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address:

2-Phenylethanol (2-PE) is an important flavor ingredient with a rose-like odor. Due to concerns about the toxic byproducts potentially found in 2-PE from chemical synthesis, consumers prefer the natural aroma compound, promoting the biosynthesis of 2-PE. Various microorganisms produce 2-PE naturally with low yield. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.005DOI Listing
February 2019
16 Reads

Site-directed chemically-modified magnetic enzymes: fabrication, improvements, biotechnological applications and future prospects.

Biotechnol Adv 2019 May - Jun;37(3):357-381. Epub 2019 Feb 12.

Life Sciences Department, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia. Electronic address:

Numerous enzymes of biotechnological importance have been immobilized on magnetic nanoparticles (MNP) via random multipoint attachment, resulting in a heterogeneous protein population with potential reduction in activity due to restriction of substrate access to the active site. Several chemistries are now available, where the modifier can be linked to a single specific amino acid in a protein molecule away from the active-site, thus enabling free access of the substrate. However, rarely these site-selective approaches have been applied to immobilize enzymes on nanoparticles. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.002DOI Listing
February 2019
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9.015 Impact Factor

Biological and chemical diversity go hand in hand: Basidiomycota as source of new pharmaceuticals and agrochemicals.

Biotechnol Adv 2019 Feb 7. Epub 2019 Feb 7.

Department of Microbial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; German Center for Infection Research, partner site Hannover-Braunschweig, 38124 Braunschweig, Germany. Electronic address:

The Basidiomycota constitutes the second largest higher taxonomic group of the Fungi after the Ascomycota and comprises over 30.000 species. Mycelial cultures of Basidiomycota have already been studied since the 1950s for production of antibiotics and other beneficial secondary metabolites. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.011DOI Listing
February 2019
6 Reads
9.015 Impact Factor

On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.

Biotechnol Adv 2019 Feb 7. Epub 2019 Feb 7.

Department of Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, United States; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:

Fungi produce an abundance of bioactive secondary metabolites which can be utilized as antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are contiguously arranged in biosynthetic gene clusters (BGCs), which supports co-regulation of all genes required for any one metabolite. However, an ongoing challenge to harvest this fungal wealth is the finding that many of the BGCs are 'silent' in laboratory settings and lie in heterochromatic regions of the genome. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.001DOI Listing
February 2019
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Curcumin, the golden spice in treating cardiovascular diseases.

Biotechnol Adv 2019 Feb 1. Epub 2019 Feb 1.

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 14359-16471, Iran. Electronic address:

Cardiovascular diseases (CVDs) cause the largest mortality worldwide, and much attention has been focused to unravel the mechanisms and optimize the treatment regimens. Curcumin is an important bioactive component of turmeric that has been widely applied as traditional medicine to prevent and treat various diseases in some countries. Recent studies have demonstrated its potent activities in modulating multiple signaling pathways associated with cellular growth, proliferation, survival, inflammation and oxidative stress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750193001
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http://dx.doi.org/10.1016/j.biotechadv.2019.01.010DOI Listing
February 2019
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Collateral sensitivity of natural products in drug-resistant cancer cells.

Biotechnol Adv 2019 Jan 29. Epub 2019 Jan 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine anticancer drugs with different modes of action to avoid the development of resistance did not provide the expected success in the past, because tumors can be simultaneously non-responsive to many drugs (e.g. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.009DOI Listing
January 2019
24 Reads
9.015 Impact Factor

Phycobiliproteins: Molecular structure, production, applications, and prospects.

Biotechnol Adv 2019 Mar - Apr;37(2):340-353. Epub 2019 Jan 25.

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong 264003, China. Electronic address:

Phycobiliproteins (PBPs) are the main component of light-harvesting complexes in cyanobacteria and red algae. In addition to their important role in photosynthesis, PBPs have many potential applications in foods, cosmetics, medical diagnosis and treatment of diseases. However, basic researches and technological innovations are urgently needed for exploring those potentials, such as structure and function, their biosynthesis as well as downstream purification. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.008DOI Listing
January 2019
2 Reads
9.015 Impact Factor

Newly isolated microorganisms with potential application in biotechnology.

Biotechnol Adv 2019 Mar - Apr;37(2):319-339. Epub 2019 Jan 18.

Laboratory of Bioflavors, Department of Food Science, School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil; Laboratory of Food Biotechnology, Food Engineering, Institute of Science and Technology, UFVJM, Diamantina, Minas Gerais, Brazil. Electronic address:

Nowadays, food, cosmetic, environmental and pharmaceutical fields are searching for alternative processes to obtain their major products in a more sustainable way. This fact is related to the increasing demand from the consumer market for natural products to substitute synthetic additives. Industrial biotechnology appears as a promising area for this purpose; however, the success of its application is highly dependent of the availability of a suitable microorganism. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.007DOI Listing
January 2019
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Harnessing cells to deliver nanoparticle drugs to treat cancer.

Biotechnol Adv 2019 Jan 11. Epub 2019 Jan 11.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, United States. Electronic address:

Clinical translation of nanoparticle drug (nanodrug) delivery systems for cancer therapy is primarily hindered by short half-life of nanodrugs in blood circulation and their poor ability of tumor targeting and penetration in vivo. Circulatory cells have garnered much attention in cancer therapy as drug delivery vehicles due to their biocompatibility, high mobility, biodegradability, tissue targeting capability, high drug loading capacity, ability to cross biological barriers and inherent ability to remain in blood circulation long enough to accumulate within the tumors. Here, we review the progress and potential of circulatory cells as nanodrug delivery vehicles, especially for cancer therapy. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.006DOI Listing
January 2019
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New bioproduction systems for chemicals and fuels: Needs and new development.

Authors:
An-Ping Zeng

Biotechnol Adv 2019 Jan 11. Epub 2019 Jan 11.

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District, 100029 Beijing, China; Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestrasse 15, D-21073 Hamburg, Germany. Electronic address:

Currently used bioproduction systems for chemicals and fuels are primarily based on sugar-containing substrates. They have inherent limitations regarding substrate sustainability and affordability, product spectrum and yield, and costs for up- and downstream processing. To overcome some of these major burdens new bioproduction strategies and systems are being developed, including biorefinery, electro-biotechnology (use of electricity for biosynthesis) and C1 bioeconomy using synthetic biological systems based on C1 carbon feedstocks such as CO, CO, methane, methanol and formic acid. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.003DOI Listing
January 2019
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Concise review: The challenges and opportunities of employing mesenchymal stromal cells in the treatment of acute pancreatitis.

Biotechnol Adv 2019 Jan 9. Epub 2019 Jan 9.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto M5S 3G9, Canada; Faculty of Dentistry, University of Toronto, Toronto M5G 1G6, Canada. Electronic address:

To date only small animal models have been employed to assess the effect of mesenchymal stromal cell (MSC) therapy on acute pancreatitis (AP), the most common cause of hospitalization for gastrointestinal diseases worldwide. We outline the challenges inherent in the small animal models of AP. We also point to specific benefits afforded by the adoption of larger animal models. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.005DOI Listing
January 2019
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Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

Biotechnol Adv 2019 Jan 8. Epub 2019 Jan 8.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States. Electronic address:

Higher plant constituents have afforded clinically available anticancer drugs. These include both chemically unmodified small molecules and their synthetic derivatives currently used or those in clinical trials as antineoplastic agents, and an updated summary is provided. In addition, botanical dietary supplements, exemplified by mangosteen and noni constituents, are also covered as potential cancer chemotherapeutic agents. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.004DOI Listing
January 2019
11 Reads

Inulin and its enzymatic production by inulosucrase: Characteristics, structural features, molecular modifications and applications.

Biotechnol Adv 2019 Mar - Apr;37(2):306-318. Epub 2019 Jan 7.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:

Inulin, a natural fructan, cannot be hydrolyzed by digestive enzymes in the human body and plays a role as a dietary fiber and prebiotic. Due to its versatile physicochemical properties and physiological functions, inulin has been widely applied in food, pharmaceuticals, and many other fields. The microorganism-derived inulin-forming enzyme inulosucrase (ISase) (EC: 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750193000
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http://dx.doi.org/10.1016/j.biotechadv.2019.01.002DOI Listing
January 2019
10 Reads

Agrobacterium-mediated horizontal gene transfer: Mechanism, biotechnological application, potential risk and forestalling strategy.

Biotechnol Adv 2019 Jan - Feb;37(1):259-270. Epub 2018 Dec 21.

College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu 225009, China.

The extraordinary capacity of Agrobacterium to transfer its genetic material to host cell makes it evolve from phytopathogen to a powerful transgenic vector. Agrobacterium-mediated stable transformation is widely used as the preferred method to create transgenic plants for molecular plant biology research and crop breeding. Recent years, both mechanism and application of Agrobacterium-mediated horizontal gene transfer have made significant progresses, especially Agrobacterium-mediated transient transformation was developed for plant biotechnology industry to produce recombinant proteins. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.12.008DOI Listing
December 2018
2 Reads