1,731 results match your criteria Biotechnology Advances [Journal]


Towards development of electrogenetics using electrochemically active bacteria.

Biotechnol Adv 2019 Feb 16. Epub 2019 Feb 16.

School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Electronic address:

Owing to the ability for efficient electric interaction with electrodes, electrochemically active bacteria (EAB) attract considerable attention in biotechnology. These bacteria are involved not only in the generation of electricity from organic wastes in microbial fuel cells but also in the production of valued chemicals with the aid of electric energy in microbial electrosynthesis systems. It has been known that metabolic activities in EAB are affected by electrode potentials, while a recent work has found that in an EAB, Shewanella oneidensis MR-1, an Arc regulatory system regulates the expression of diverse catabolic genes by sensing electrode potentials. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.007DOI Listing
February 2019

The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challenges.

Biotechnol Adv 2019 Feb 16. Epub 2019 Feb 16.

Nutrition and Food Science Area, Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda.Vicent Andrés Estellés, s/n, 46100, Burjassot, València, Spain. Electronic address:

The recent progress in genetic engineering has brought multiple benefits to the food and agricultural industry by enhancing essential characteristics of agronomic traits. Powerful tools in the field of genome editing, such as siRNA-mediated RNA interference for targeted suppression of gene expression and transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs) for DNA repair have been widely used for commercial purposes. However, in the last few years, the discovery of the CRISPR-Cas9 system has revolutionized genome editing and has attracted attention as a powerful tool for several industrial applications. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.006DOI Listing
February 2019
1 Read

Engineered microbial host selection for value-added bioproducts from lignocellulose.

Biotechnol Adv 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

Lignocellulose is a rich and sustainable globally available carbon source and is considered a prominent alternative raw material for producing biofuels and valuable chemical compounds. Enzymatic hydrolysis is one of the crucial steps of lignocellulose degradation. Cellulolytic and hemicellulolytic enzyme mixes produced by different microorganisms including filamentous fungi, yeasts and bacteria, are used to degrade the biomass to liberate monosaccharides and other compounds for fermentation or conversion to value-added products. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.003DOI Listing
February 2019

Harnessing the catabolic versatility of Gordonia species for detoxifying pollutants.

Biotechnol Adv 2019 Feb 13. Epub 2019 Feb 13.

Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune University, Pune 411007, India; Department of Microbiology, Savitribai Phule Pune University, Pune 411007, India. Electronic address:

The genus Gordonia includes variedly pigmented aerobic, non-motile, non-sporulating Gram positive (sometimes variable) coccoid forms and rods. Different isolates display distinguishing physiological traits and biochemical properties that are significant in remediation applications. Strains inherently prevalent in soils, seawater, sediments and wastewaters can degrade hydrocarbons. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.004DOI Listing
February 2019

Advances in 2-phenylethanol production from engineered microorganisms.

Biotechnol Adv 2019 Feb 13. Epub 2019 Feb 13.

The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Research Centre of Industrial Microbiology, School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address:

2-Phenylethanol (2-PE) is an important flavor ingredient with a rose-like odor. Due to concerns about the toxic byproducts potentially found in 2-PE from chemical synthesis, consumers prefer the natural aroma compound, promoting the biosynthesis of 2-PE. Various microorganisms produce 2-PE naturally with low yield. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.005DOI Listing
February 2019
2 Reads

Site-directed chemically-modified magnetic enzymes: fabrication, improvements, biotechnological applications and future prospects.

Biotechnol Adv 2019 Feb 12. Epub 2019 Feb 12.

Life Sciences Department, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia. Electronic address:

Numerous enzymes of biotechnological importance have been immobilized on magnetic nanoparticles (MNP) via random multipoint attachment, resulting in a heterogeneous protein population with potential reduction in activity due to restriction of substrate access to the active site. Several chemistries are now available, where the modifier can be linked to a single specific amino acid in a protein molecule away from the active-site, thus enabling free access of the substrate. However, rarely these site-selective approaches have been applied to immobilize enzymes on nanoparticles. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.002DOI Listing
February 2019

Biological and chemical diversity go hand in hand: Basidomycota as source of new pharmaceuticals and agrochemicals.

Biotechnol Adv 2019 Feb 7. Epub 2019 Feb 7.

Department of Microbial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; German Center for Infection Research, partner site Hannover-Braunschweig, 38124 Braunschweig, Germany. Electronic address:

The Basidiomycota constitutes the second largest higher taxonomic group of the Fungi after the Ascomycota and comprises over 30.000 species. Mycelial cultures of Basidiomycota have already been studied since the 1950s for production of antibiotics and other beneficial secondary metabolites. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.011DOI Listing
February 2019
1 Read
9.015 Impact Factor

On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.

Biotechnol Adv 2019 Feb 7. Epub 2019 Feb 7.

Department of Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, United States; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, United States. Electronic address:

Fungi produce an abundance of bioactive secondary metabolites which can be utilized as antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are contiguously arranged in biosynthetic gene clusters (BGCs), which supports co-regulation of all genes required for any one metabolite. However, an ongoing challenge to harvest this fungal wealth is the finding that many of the BGCs are 'silent' in laboratory settings and lie in heterochromatic regions of the genome. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.001DOI Listing
February 2019
1 Read

Curcumin, the golden spice in treating cardiovascular diseases.

Biotechnol Adv 2019 Feb 1. Epub 2019 Feb 1.

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 14359-16471, Iran. Electronic address:

Cardiovascular diseases (CVDs) cause the largest mortality worldwide, and much attention has been focused to unravel the mechanisms and optimize the treatment regimens. Curcumin is an important bioactive component of turmeric that has been widely applied as traditional medicine to prevent and treat various diseases in some countries. Recent studies have demonstrated its potent activities in modulating multiple signaling pathways associated with cellular growth, proliferation, survival, inflammation and oxidative stress. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.010DOI Listing
February 2019
7 Reads

Collateral sensitivity of natural products in drug-resistant cancer cells.

Biotechnol Adv 2019 Jan 29. Epub 2019 Jan 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine anticancer drugs with different modes of action to avoid the development of resistance did not provide the expected success in the past, because tumors can be simultaneously non-responsive to many drugs (e.g. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.009DOI Listing
January 2019
9 Reads
9.015 Impact Factor

Phycobiliproteins: Molecular structure, production, applications, and prospects.

Biotechnol Adv 2019 Mar - Apr;37(2):340-353. Epub 2019 Jan 25.

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong 264003, China. Electronic address:

Phycobiliproteins (PBPs) are the main component of light-harvesting complexes in cyanobacteria and red algae. In addition to their important role in photosynthesis, PBPs have many potential applications in foods, cosmetics, medical diagnosis and treatment of diseases. However, basic researches and technological innovations are urgently needed for exploring those potentials, such as structure and function, their biosynthesis as well as downstream purification. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.008DOI Listing
January 2019
1 Read
9.015 Impact Factor

Newly isolated microorganisms with potential application in biotechnology.

Biotechnol Adv 2019 Mar - Apr;37(2):319-339. Epub 2019 Jan 18.

Laboratory of Bioflavors, Department of Food Science, School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil; Laboratory of Food Biotechnology, Food Engineering, Institute of Science and Technology, UFVJM, Diamantina, Minas Gerais, Brazil. Electronic address:

Nowadays, food, cosmetic, environmental and pharmaceutical fields are searching for alternative processes to obtain their major products in a more sustainable way. This fact is related to the increasing demand from the consumer market for natural products to substitute synthetic additives. Industrial biotechnology appears as a promising area for this purpose; however, the success of its application is highly dependent of the availability of a suitable microorganism. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.007DOI Listing
January 2019
1 Read

Harnessing cells to deliver nanoparticle drugs to treat cancer.

Biotechnol Adv 2019 Jan 11. Epub 2019 Jan 11.

School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, United States. Electronic address:

Clinical translation of nanoparticle drug (nanodrug) delivery systems for cancer therapy is primarily hindered by short half-life of nanodrugs in blood circulation and their poor ability of tumor targeting and penetration in vivo. Circulatory cells have garnered much attention in cancer therapy as drug delivery vehicles due to their biocompatibility, high mobility, biodegradability, tissue targeting capability, high drug loading capacity, ability to cross biological barriers and inherent ability to remain in blood circulation long enough to accumulate within the tumors. Here, we review the progress and potential of circulatory cells as nanodrug delivery vehicles, especially for cancer therapy. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.006DOI Listing
January 2019
1 Read

New bioproduction systems for chemicals and fuels: Needs and new development.

Authors:
An-Ping Zeng

Biotechnol Adv 2019 Jan 11. Epub 2019 Jan 11.

Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestrasse 15, D-21073 Hamburg, Germany; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District, 100029 Beijing, China. Electronic address:

Currently used bioproduction systems for chemicals and fuels are primarily based on sugar-containing substrates. They have inherent limitations regarding substrate sustainability and affordability, product spectrum and yield, and costs for up- and downstream processing. To overcome some of these major burdens new bioproduction strategies and systems are being developed, including biorefinery, electro-biotechnology (use of electricity for biosynthesis) and C1 bioeconomy using synthetic biological systems based on C1 carbon feedstocks such as CO, CO, methane, methanol and formic acid. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.003DOI Listing
January 2019
1 Read

Concise review: The challenges and opportunities of employing mesenchymal stromal cells in the treatment of acute pancreatitis.

Biotechnol Adv 2019 Jan 9. Epub 2019 Jan 9.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto M5S 3G9, Canada; Faculty of Dentistry, University of Toronto, Toronto M5G 1G6, Canada. Electronic address:

To date only small animal models have been employed to assess the effect of mesenchymal stromal cell (MSC) therapy on acute pancreatitis (AP), the most common cause of hospitalization for gastrointestinal diseases worldwide. We outline the challenges inherent in the small animal models of AP. We also point to specific benefits afforded by the adoption of larger animal models. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.005DOI Listing
January 2019
2 Reads

Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

Biotechnol Adv 2019 Jan 8. Epub 2019 Jan 8.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States. Electronic address:

Higher plant constituents have afforded clinically available anticancer drugs. These include both chemically unmodified small molecules and their synthetic derivatives currently used or those in clinical trials as antineoplastic agents, and an updated summary is provided. In addition, botanical dietary supplements, exemplified by mangosteen and noni constituents, are also covered as potential cancer chemotherapeutic agents. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.004DOI Listing
January 2019
6 Reads

Inulin and its enzymatic production by inulosucrase: Characteristics, structural features, molecular modifications and applications.

Biotechnol Adv 2019 Mar - Apr;37(2):306-318. Epub 2019 Jan 7.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:

Inulin, a natural fructan, cannot be hydrolyzed by digestive enzymes in the human body and plays a role as a dietary fiber and prebiotic. Due to its versatile physicochemical properties and physiological functions, inulin has been widely applied in food, pharmaceuticals, and many other fields. The microorganism-derived inulin-forming enzyme inulosucrase (ISase) (EC: 2. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.01.002DOI Listing
January 2019
6 Reads

Agrobacterium-mediated horizontal gene transfer: Mechanism, biotechnological application, potential risk and forestalling strategy.

Biotechnol Adv 2019 Jan - Feb;37(1):259-270. Epub 2018 Dec 21.

College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu 225009, China.

The extraordinary capacity of Agrobacterium to transfer its genetic material to host cell makes it evolve from phytopathogen to a powerful transgenic vector. Agrobacterium-mediated stable transformation is widely used as the preferred method to create transgenic plants for molecular plant biology research and crop breeding. Recent years, both mechanism and application of Agrobacterium-mediated horizontal gene transfer have made significant progresses, especially Agrobacterium-mediated transient transformation was developed for plant biotechnology industry to produce recombinant proteins. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.12.008DOI Listing
December 2018
1 Read

Regulation of glycolytic flux and overflow metabolism depending on the source of energy generation for energy demand.

Biotechnol Adv 2019 Mar - Apr;37(2):284-305. Epub 2018 Dec 18.

Kyushu Institute of Technology, Iizuka, Fukuoka 820-8502, Japan.

Overflow metabolism is a common phenomenon observed at higher glycolytic flux in many bacteria, yeast (known as Crabtree effect), and mammalian cells including cancer cells (known as Warburg effect). This phenomenon has recently been characterized as the trade-offs between protein costs and enzyme efficiencies based on coarse-graining approaches. Moreover, it has been recognized that the glycolytic flux increases as the source of energy generation changes from energetically efficient respiration to inefficient respiro-fermentative or fermentative metabolism causing overflow metabolism. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.12.007DOI Listing
December 2018
2 Reads

Engineering of filamentous fungi for efficient conversion of lignocellulose: Tools, recent advances and prospects.

Biotechnol Adv 2018 Dec 18. Epub 2018 Dec 18.

State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China; National Glycoengineering Research Center, Shandong University, Qingdao 266237, China. Electronic address:

Filamentous fungi, as the main producers of lignocellulolytic enzymes in industry, need to be engineered to improve the economy of large-scale lignocellulose conversion. Investigation of the cellular processes involved in lignocellulolytic enzyme production, as well as optimization of enzyme mixtures for higher hydrolysis efficiency, have provided effective targets for the engineering of lignocellulolytic fungi. Recently, the development of efficient genetic manipulation systems in several lignocellulolytic fungi opens up the possibility of systems engineering of these strains. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.12.004DOI Listing
December 2018
1 Read

Cell-free supplement mixtures: Elucidating the history and biochemical utility of additives used to support in vitro protein synthesis in E. coli extract.

Biotechnol Adv 2019 Jan - Feb;37(1):246-258. Epub 2018 Dec 17.

Department of Chemical and Biological Engineering, Iowa State University, USA. Electronic address:

Cell-free protein synthesis (CFPS) has become an established biotechnology tool for rapid protein expression. Over the past few decades many advances have elevated CFPS from a niche, low-efficiency system to one now capable of biomanufacturing custom proteins. Many research papers and reviews exist on the advances made in CFPS genetic template and cell extract preparation for use in E. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07349750183020
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http://dx.doi.org/10.1016/j.biotechadv.2018.12.006DOI Listing
December 2018
7 Reads

Production of biofuels and chemicals from xylose using native and engineered yeast strains.

Biotechnol Adv 2019 Mar - Apr;37(2):271-283. Epub 2018 Dec 14.

Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul 08826, South Korea. Electronic address:

Numerous metabolic engineering strategies have allowed yeasts to efficiently assimilate xylose, the second most abundant sugar component of lignocellulosic biomass. During the investigation of xylose utilization by yeasts, a global rewiring of metabolic networks upon xylose cultivation has been captured, as opposed to a pattern of glucose repression. A clear understanding of the xylose-induced metabolic reprogramming in yeast would shed light on the optimization of yeast-based bioprocesses to produce biofuels and chemicals using xylose. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.12.003DOI Listing
December 2018
2 Reads

Standardizing CAR-T therapy: Getting it scaled up.

Biotechnol Adv 2019 Jan - Feb;37(1):239-245. Epub 2018 Dec 10.

Department of Molecular & Immunological Research, Bio-therapeutic Department, Chinese PLA General Hospital, Beijing 100853, China. Electronic address:

CAR-T therapy, grafting the specificity of a monoclonal antibody onto a T cell to target certain cancer cells, has been recognized as a promising therapeutic approach for cancer control as evidenced by the two CAR-T products proved by FDA in 2017. However, the unique heterogeneity of CAR-T therapy has restricted its production in a limited number of institutions and made it a boutique oncotherapy. By reviewing outstanding issues surrounding the commercial scale production of CAR-T therapy, we conclude that achieving mass production of CAR-T therapy without sacrificing its personalized nature is a worldwild challenge for making CAR-T a key element in the next generation of precision medicine, which can be achieved by standardizing 7 prominent factors that collectively determine the scale of CAR-T manufacturing. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.12.002DOI Listing
December 2018
2 Reads

Tools and strategies for constructing cell-free enzyme pathways.

Biotechnol Adv 2019 Jan - Feb;37(1):91-108. Epub 2018 Dec 3.

Department of Molecular Sciences, Macquarie University, Sydney, Australia; Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, Australia. Electronic address:

Single enzyme systems or engineered microbial hosts have been used for decades but the notion of assembling multiple enzymes into cell-free synthetic pathways is a relatively new development. The extensive possibilities that stem from this synthetic concept makes it a fast growing and potentially high impact field for biomanufacturing fine and platform chemicals, pharmaceuticals and biofuels. However, the translation of individual single enzymatic reactions into cell-free multi-enzyme pathways is not trivial. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.007DOI Listing
December 2018
3 Reads

Bioactivity of soy-based fermented foods: A review.

Biotechnol Adv 2019 Jan - Feb;37(1):223-238. Epub 2018 Dec 4.

College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China. Electronic address:

For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, fermented soy milk, Tempeh and soy sauce. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.12.001DOI Listing
December 2018
10 Reads

Tracking antigen specific T-cells: Technological advancement and limitations.

Biotechnol Adv 2019 Jan - Feb;37(1):145-153. Epub 2018 Nov 30.

Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD 4072, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, QLD 4072, Australia. Electronic address:

Assessing T-cell mediated immune status can help to understand the body's response to disease and also provide essential diagnostic information. However, detection and characterization of immune response are challenging due to the rarity of signature biomolecules in biological fluid and require highly sensitive and specific assay technique for the analysis. Until now, several techniques spanning from flow cytometry to microsensors have been developed or under investigation for T-cell mediated immune response monitoring. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.010DOI Listing
November 2018
1 Read

New horizons in culture and valorization of red microalgae.

Biotechnol Adv 2019 Jan - Feb;37(1):193-222. Epub 2018 Nov 28.

CNRS, SIGMA Clermont, Institut Pascal, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France. Electronic address:

Research on marine microalgae has been abundantly published and patented these last years leading to the production and/or the characterization of some biomolecules such as pigments, proteins, enzymes, biofuels, polyunsaturated fatty acids, enzymes and hydrocolloids. This literature focusing on metabolic pathways, structural characterization of biomolecules, taxonomy, optimization of culture conditions, biorefinery and downstream process is often optimistic considering the valorization of these biocompounds. However, the accumulation of knowledge associated with the development of processes and technologies for biomass production and its treatment has sometimes led to success in the commercial arena. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.014DOI Listing
November 2018
2 Reads

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies.

Biotechnol Adv 2019 Jan - Feb;37(1):177-192. Epub 2018 Nov 27.

Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada. Electronic address:

Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.013DOI Listing
November 2018
1 Read

From biotechnology principles to functional and low-cost metallic bionanocatalysts.

Biotechnol Adv 2019 Jan - Feb;37(1):154-176. Epub 2018 Nov 24.

Nanotechnology Centre, VŠB - Technical University of Ostrava, 17. listopadu 15/2172, Ostrava, Czech Republic; ENET Centre, VŠB - Technical University of Ostrava, 17. listopadu 15/2172, Ostrava, Czech Republic.

Chemical, physical and mechanical methods of nanomaterial preparation are still regarded as mainstream methods, and the scientific community continues to search for new ways of nanomaterial preparation. The major objective of this review is to highlight the advantages of using green chemistry and bionanotechnology in the preparation of functional low-cost catalysts. Bionanotechnology employs biological principles and processes connected with bio-phase participation in both design and development of nano-structures and nano-materials, and the biosynthesis of metallic nanoparticles is becoming even more popular due to; (i) economic and ecologic effectiveness, (ii) simple one-step nanoparticle formation, stabilisation and biomass support and (iii) the possibility of bio-waste valorisation. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.012DOI Listing
November 2018
12 Reads

Dietary phytochemicals in colorectal cancer prevention and treatment: A focus on the molecular mechanisms involved.

Biotechnol Adv 2018 Nov 23. Epub 2018 Nov 23.

Nutrition and Food Science Group, Dept. of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo, Vigo Campus, Vigo, (Spain); Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Ancona 60131, Italy. Electronic address:

Worldwide, colorectal cancer (CRC) remains a major cancer type and leading cause of death. Unfortunately, current medical treatments are not sufficient due to lack of effective therapy, adverse side effects, chemoresistance and disease recurrence. In recent decades, epidemiologic observations have highlighted the association between the ingestion of several phytochemical-enriched foods and nutrients and the lower risk of CRC. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.011DOI Listing
November 2018
3 Reads

Biomaterials of PVA and PVP in medical and pharmaceutical applications: Perspectives and challenges.

Biotechnol Adv 2019 Jan - Feb;37(1):109-131. Epub 2018 Nov 22.

″Petru Poni″ Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania. Electronic address:

Poly(vinyl alcohol) (PVA) has attracted considerable research interest and is recognized among the largest volume of synthetic polymers that have been produced worldwide for almost one century. This is due to its exceptional properties which dictated its extensive use in a wide variety of applications, especially in medical and pharmaceutical fields. However, studies revealed that PVA-based biomaterials present some limitations that can restrict their use or performances. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.008DOI Listing
November 2018
14 Reads

A comprehensive review on histone-mediated transfection for gene therapy.

Biotechnol Adv 2019 Jan - Feb;37(1):132-144. Epub 2018 Nov 23.

Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China. Electronic address:

Histone has been considered to be an effective carrier in non-viral gene delivery due to its unique properties such as efficient DNA binding ability, direct translocation to cytoplasm and favorable nuclear localization ability. Meanwhile, the rapid development of genetic engineering techniques could facilitate the construction of multifunctional fusion proteins based on histone molecules to further improve the transfection efficiency. Remarkably, histone has been demonstrated to achieve gene transfection in a synergistic manner with cationic polymers, affording to a significant improvement of transfection efficiency. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.009DOI Listing
November 2018
10 Reads

Quorum sensing inhibitors as antipathogens: biotechnological applications.

Biotechnol Adv 2019 Jan - Feb;37(1):68-90. Epub 2018 Nov 22.

Department of Chemical Engineering, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

The mechanisms through which microbes communicate using signal molecules has inspired a great deal of research. Microbes use this exchange of information, known as quorum sensing (QS), to initiate and perpetuate infectious diseases in eukaryotic organisms, evading the eukaryotic defense system by multiplying and expressing their pathogenicity through QS regulation. The major issue to arise from such networks is increased bacterial resistance to antibiotics, resulting from QS-dependent mediation of the formation of biofilm, the induction of efflux pumps, and the production of antibiotics. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.006DOI Listing
November 2018
11 Reads

Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering.

Biotechnol Adv 2018 Nov 17. Epub 2018 Nov 17.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Plants, fungi, and microorganisms are equipped with biosynthesis machinery for producing thousands of secondary metabolites. These compounds have important functions in nature as a defence against predators or competitors as well as other ecological significances. The full utilization of these compounds for food, medicine, and other purposes requires a thorough understanding of their structures and the distinct biochemical pathways of their production in cellular systems. Read More

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November 2018
21 Reads

Anhydrobiosis: Inside yeast cells.

Biotechnol Adv 2019 Jan - Feb;37(1):51-67. Epub 2018 Nov 16.

UMR Procédés Alimentaires et Microbiologiques, Univ. Bourgogne Franche-Comté, AgroSup Dijon, PAM UMR A 02.102, F-, Dijon 21000, France.

Under natural conditions yeast cells as well as other microorganisms are regularly subjected to the influence of severe drought, which leads to their serious dehydration. The dry seasons are then changed by rains and there is a restoration of normal water potential inside the cells. To survive such seasonal changes a lot of vegetative microbial cells, which belong to various genera and species, may be able to enter into a state of anhydrobiosis, in which their metabolism is temporarily and reversibly suspended or delayed. Read More

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November 2018
8 Reads

Advances in thermochemical conversion of woody biomass to energy, fuels and chemicals.

Authors:
Shusheng Pang

Biotechnol Adv 2018 Nov 14. Epub 2018 Nov 14.

Department of Chemical and Process Engineering, University of Canterbury, Christchurch, New Zealand; School of Mechanical and Power Engineering, Henan Polytechnic University, Jiaozuo, China; Henan Centre for Outstanding Overseas Scientists, School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou, China. Electronic address:

Biomass has been recognised as a promising resource for future energy and fuels. The biomass, originated from plants, is renewable and application of its derived energy and fuels is close to carbon-neutral by considering that the growing plants absorb CO for photosynthesis. However, the complex physical structure and chemical composition of the biomass significantly hinder its conversion to gaseous and liquid fuels. Read More

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November 2018
10 Reads

Engineering stilbene metabolic pathways in microbial cells.

Biotechnol Adv 2018 12 9;36(8):2264-2283. Epub 2018 Nov 9.

Induced Resistance and Plant Bioprotection, Faculty of Sciences University of Reims Champagne-Ardenne, PO Box 1039, EA 4707, SFR Condorcet FR CNRS 3417, Reims Cedex 51687, France.

Numerous in vitro and in vivo studies on biological activities of phytostilbenes have brought to the fore the remarkable properties of these compounds and their derivatives, making them a top storyline in natural product research fields. However, getting stilbenes in sufficient amounts for routine biological activity studies and make them available for pharmaceutical and/or nutraceutical industry applications, is hampered by the difficulty to source them through synthetic chemistry-based pathways or extraction from the native plants. Hence, microbial cell cultures have rapidly became potent workhorse factories for stilbene production. Read More

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December 2018
12 Reads

Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development.

Biotechnol Adv 2019 Jan - Feb;37(1):28-50. Epub 2018 Nov 5.

Centre for Comparative Genomics, Murdoch University, Perth 6150, Australia; Perron Institute for Neurological and Translational Science, Perth 6009, Australia. Electronic address:

Aptamers are short single-stranded nucleic acid sequences capable of binding to target molecules in a way similar to antibodies. Due to various advantages such as prolonged shelf life, low batch to batch variation, low/no immunogenicity, freedom to incorporate chemical modification for enhanced stability and targeting capacity, aptamers quickly found their potential in diverse applications ranging from therapy, drug delivery, diagnosis, and functional genomics to bio-sensing. Aptamers are generated by a process called SELEX. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.11.001DOI Listing
November 2018
15 Reads

CRISPR-Cpf1-mediated genome editing and gene regulation in human cells.

Biotechnol Adv 2019 Jan - Feb;37(1):21-27. Epub 2018 Nov 3.

Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China. Electronic address:

Clustered regularly interspaced short palindromic repeat (CRISPR) system is being championed as a robust and flexible tool for genome editing. Compared with CRISPR associated protein 9 (Cas9), the CRISPR from Prevotella and Francisella 1 (Cpf1) protein has some distinct characteristics, including RNase activity, T-rich protospacer adjacent motif (PAM) preference and generation of sticky cutting ends. The extremely low propensity of off-target effects and relatively high editing efficiency represent prominent advantages of Cpf1 over Cas9. Read More

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November 2018
11 Reads

Biobased adipic acid - The challenge of developing the production host.

Biotechnol Adv 2018 12 30;36(8):2248-2263. Epub 2018 Oct 30.

Department of Biology and Biological Engineering, Division of Industrial Biotechnology, Chalmers University of Technology, Gothenburg SE-412 96, Sweden. Electronic address:

Adipic acid is a platform chemical, and is the most important commercial dicarboxylic acid. It has been targeted for biochemical conversion as an alternative to present chemical production routes. From the perspective of bioeconomy, several kinds of raw material are of interest including the sugar platform (derived from starch, cellulose or hemicellulose), the lignin platform (aromatics) and the fatty acid platform (lipid derived). Read More

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December 2018
20 Reads

Microbial production of small medicinal molecules and biologics: From nature to synthetic pathways.

Biotechnol Adv 2018 12 29;36(8):2219-2231. Epub 2018 Oct 29.

School of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USA. Electronic address:

Natural products are promising chemicals due to their structural diversity and bioactivities. Over the decades, a vast variety of gene clusters encoding natural products have been identified and overexpressed in microbes. Recently, the development of metabolic engineering, synthetic biology and bioinformatics strategies have facilitated target discovery and design. Read More

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December 2018
3 Reads

Microbial production of bacteriocins: Latest research development and applications.

Biotechnol Adv 2018 12 29;36(8):2187-2200. Epub 2018 Oct 29.

Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island 627833, Singapore. Electronic address:

Bacteriocins are low molecular weight peptides secreted by the predator bacterial cells to kill sensitive cells present in the same ecosystem competing for food and other nutrients. Exceptionally few bacteriocins along with their native antibacterial property also exhibit additional anti-viral and anti-fungal properties. Bacteriocins are generally produced by Gm+, Gm- and archaea bacteria. Read More

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December 2018
13 Reads
9.015 Impact Factor

The Yin and Yang of carbon nanomaterials in atherosclerosis.

Biotechnol Adv 2018 12 17;36(8):2232-2247. Epub 2018 Oct 17.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

With unique characteristics such as high surface area, capacity of various functionalization, low weight, high conductivity, thermal and chemical stability, and free radical scavenging, carbon nanomaterials (CNMs) such as carbon nanotubes (CNTs), fullerene, graphene (oxide), carbon nanohorns (CNHs), and their derivatives have increasingly been utilized in nanomedicine and biomedicine. On the one hand, owing to ever-increasing applications of CNMs in technological and industrial fields as well as presence of combustion-derived CNMs in the ambient air, the skepticism has risen over the adverse effects of CNMs on human being. The influences of CNMs on cardiovascular system and cardiovascular diseases (CVDs) such as atherosclerosis, of which consequences are ischemic heart disease and ischemic stroke, as the main causes of death, is of paramount importance. Read More

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December 2018
3 Reads
9.020 Impact Factor

Hidden antibiotics: Where to uncover?

Biotechnol Adv 2018 12 17;36(8):2201-2218. Epub 2018 Oct 17.

Centre for Industrial Biotechnology and Biocatalysis (InBio.be), Department Biochemical and Microbial Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.

The struggle of humans versus pathogens is a never ending battle. Since the discovery of antibiotics humans have tipped the scales in their favour, but today bacteria are nullifying this advantage by developing resistance mechanisms against these molecules. The plethora of different antibiotics active against pathogens is shrinking while the discovery of new molecules is arduous. Read More

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December 2018
1 Read

Strain engineering for microbial production of value-added chemicals and fuels from glycerol.

Biotechnol Adv 2018 Oct 17. Epub 2018 Oct 17.

Department of Chemical Engineering, Waterloo, Ontario, Canada. Electronic address:

While the widespread reliance on fossil fuels is driven by their low cost and relative abundance, this fossil-based economy has been deemed unsustainable and, therefore, the adoption of sustainable and environmentally compatible energy sources is on the horizon. Biorefinery is an emerging approach that integrates metabolic engineering, synthetic biology, and systems biology principles for the development of whole-cell catalytic platforms for biomanufacturing. Due to the high degree of reduction and low cost, glycerol, either refined or crude, has been recognized as an ideal feedstock for the production of value-added biologicals, though microbial dissimilation of glycerol sometimes can be difficult particularly under anaerobic conditions. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.10.006DOI Listing
October 2018
11 Reads

The physiology and biotechnology of dark fermentative biohydrogen production.

Biotechnol Adv 2018 12 12;36(8):2165-2186. Epub 2018 Oct 12.

Archaea Physiology & Biotechnology Group, Archaea Biology and Ecogenomics Division, Department of Ecogenomics and Systems Biology, Universität Wien, Wien, Austria. Electronic address:

A CO-neutral energy production alternative compared to conventional fossil fuel utilization is biohydrogen (H) production. Three basic mechanisms for microbial H production exist: photosynthetic H production, photo-fermentative H production, and dark fermentative H production (DFHP). Despite surmounting reports in literature on the characterization and optimization of DFHP systems, H production has not yet reached an industrial scale. Read More

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December 2018
3 Reads

Synthetic biology tools for engineering Yarrowia lipolytica.

Biotechnol Adv 2018 12 11;36(8):2150-2164. Epub 2018 Oct 11.

Department of Bioengineering and Imperial College Centre for Synthetic Biology, Imperial College London, London, United Kingdom. Electronic address:

The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this review, we present recently developed synthetic biology tools that facilitate the manipulation of Y. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261845PMC
December 2018
2 Reads

Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.

Biotechnol Adv 2019 Jan - Feb;37(1):1-20. Epub 2018 Oct 9.

Harbor Branch Oceanographic Institute, Florida Atlantic University, 5600 U.S. 1 North, Fort Pierce, FL 34946, USA. Electronic address:

Due to the worldwide prevalence of multidrug-resistant pathogens and high incidence of diseases such as cancer, there is an urgent need for the discovery and development of new drugs. Nearly half of the FDA-approved drugs are derived from natural products that are produced by living organisms, mainly bacteria, fungi, and plants. Commercial development is often limited by the low yield of the desired compounds expressed by the native producers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343487PMC
October 2018
1 Read

Fate of degraded pollutants in waste gas biofiltration: An overview of carbon end-points.

Biotechnol Adv 2018 Oct 9. Epub 2018 Oct 9.

Department of Chemical and Process Engineering, University of Canterbury, New Zealand. Electronic address:

The fate of the carbon from degraded pollutants in biofiltration is not well understood. The issue of missing carbon needs to be addressed quantitatively to better understand and model biofilter performance. Elucidating the various carbon end-points in various phases should contribute to the fundamental understanding of the degradation kinetics and metabolic pathways as a function of various environmental parameters. Read More

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October 2018
2 Reads

Multiscale heterogeneity in filamentous microbes.

Biotechnol Adv 2018 12 5;36(8):2138-2149. Epub 2018 Oct 5.

Microbial Biotechnology, Institute of Biology, Leiden University, Sylviusweg 72, 2333, BE, Leiden, The Netherlands.. Electronic address:

Microbial cells within clonal populations can display different morphologies or carry out different tasks. This heterogeneity is beneficial at the population level and allows microbes to spread risk or separate incompatible activities. Heterogeneity is also evident in filamentous bacteria and fungi, which form mycelial networks consisting of interconnected hyphae. Read More

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December 2018
1 Read