375,864 results match your criteria Biotechnology & Genetic Engineering Reviews[Journal]


Patterns of bacterial and archaeal communities in sediments in response to dam construction and sewage discharge in Lhasa River.

Ecotoxicol Environ Saf 2019 Apr 19;178:195-201. Epub 2019 Apr 19.

Department of Water Resources and Hydropower Engineering, Wuhan University, Wuhan, 430000, China. Electronic address:

The increased anthropogenic activities in the Tibetan Plateau may threaten the river environmental safety. However, limited information is available on the Lhasa River in the Tibetan Plateau, which is known as the remaining pure land on Earth. Here, we firstly investigated the distribution patterns of bacterial and archaeal communities in sediments in response to dam construction and sewage discharge along the reaches of the Lhasa River. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.03.107DOI Listing

Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.

Eur J Med Chem 2019 Apr 6;173:213-227. Epub 2019 Apr 6.

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi'an, 710069, China. Electronic address:

TMCA (3,4,5-trimethoxycinnamic acid) ester and amide are privileged structural scaffolds in drug discovery which are widely distributed in natural products and consequently produced diverse therapeutically relevant pharmacological functions. Owing to the potential of TMCA ester and amide analogues as therapeutic agents, researches on chemical syntheses and modifications have been carried out to drug-like candidates with broad range of medicinal properties such as antitumor, antiviral, CNS (central nervous system) agents, antimicrobial, anti-inflammatory and hematologic agents for a long time. At the same time, SAR (structure-activity relationship) studies have draw greater attention among medicinal chemists, and many of the lead compounds were derived for various disease targets. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.009DOI Listing

Improved electrocatalytic activity of Au@FeO magnetic nanoparticles for sensitive dopamine detection.

Colloids Surf B Biointerfaces 2019 Apr 16;180:1-8. Epub 2019 Apr 16.

Electroorganic Division, CSIR-Central Electrochemical Research Institute, Karaikudi 630003, India. Electronic address:

Substantially, noble metals are important for the development of low-cost, sensitive, selective, superior performance, and portable electrochemical sensors. Herein, we describe gold (Au) nanoparticles (NPs) systematically decorated with magnetic FeO nanocomposites on the fabrication of sensitive dopamine sensor is described. Magnetic Au@FeO nanocomposites were prepared by reducing HAuCl on the surfaces of FeO nanoparticles. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.034DOI Listing

Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages.

Phytomedicine 2018 Dec 10;59:152785. Epub 2018 Dec 10.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address:

Background: Bavachin is a natural product isolated from Psoralea corylifolia L. that has been applied as a traditional medicine in Asian countries. However, the anti-inflammatory effects of bavachin on LPS-induced inflammation and NLRP3 inflammasome activation by macrophages remain unclear. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.008DOI Listing
December 2018

The use of rapid, small-scale column tests to determine the efficiency of bauxite residue as a low-cost adsorbent in the removal of dissolved reactive phosphorus from agricultural waters.

J Environ Manage 2019 Apr 19;241:273-283. Epub 2019 Apr 19.

Civil Engineering, National University of Ireland, Galway, Ireland. Electronic address:

Bauxite residue, the by-product produced in the alumina industry, is a potential low-cost adsorbent in the removal of phosphorus (P) from aqueous solution, due to its high composition of residual iron oxides such as hematite. Several studies have investigated the performance of bauxite residue in removing P; however, the majority have involved the use of laboratory "batch" tests, which may not accurately estimate its actual performance in filter systems. This study investigated the use of rapid, small-scale column tests to predict the dissolved reactive phosphorus (DRP) removal capacity of bauxite residue when treating two agricultural waters of low (forest run-off) and high (dairy soiled water) phosphorus content. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03014797193049
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http://dx.doi.org/10.1016/j.jenvman.2019.04.042DOI Listing
April 2019
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Efficacy of live attenuated vaccine derived from the Streptococcus agalactiae on the immune responses of Oreochromis niloticus.

Fish Shellfish Immunol 2019 Apr 19. Epub 2019 Apr 19.

School of Fisheries and Aquaculture Sciences, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia; Institute of Tropical Aquaculture, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.

Streptococcus agalactiae species have been recognized as the main pathogen causing high mortality in fish leading to significant worldwide economical losses to the aquaculture industries. Vaccine development has become a priority in combating multidrug resistance in bacteria; however, there is a lack of commercial live attenuated vaccine (LAV) against S. agalactiae in Malaysia. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.052DOI Listing

Identification and bioactivity of a granulocyte colony-stimulating factor b homologue from large yellow croaker (Larimichthys crocea).

Fish Shellfish Immunol 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, 361005, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

Granulocyte colony-stimulating factor (GCSF) is a pleiotropic cytokine that plays a key role in regulation of hematopoiesis, innate and adaptive immune responses in mammals. However, bioactivity of GCSF in teleost fish remains largely unknown. In this study, a GCSFb homologue from large yellow croaker (Larimichthys crocea) (LcGCSFb) was cloned by RACE-PCR techniques. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.048DOI Listing

A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent.

Mitochondrion 2019 Apr 19. Epub 2019 Apr 19.

Department of Inborn Errors of Metabolism, FSBI 'Research Centre for Medical Genetics', Moscow, Russia.

We present a 14-year-old girl with loss of motor functions, tetraplegia, epilepsy and nystagmus, caused by a novel heteroplasmic m.641A>T transition in an evolutionary conserved region of mitochondrial genome, affecting the aminoacyl stem of mitochondrial tRNA-Phe. In silico prediction, respirometry, Western blot and enzymatic analyses in skin fibroblasts support the pathogenicity of the m. Read More

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http://dx.doi.org/10.1016/j.mito.2019.04.004DOI Listing

Genetic status of indigenous poultry (red jungle fowl) from India.

Gene 2019 Apr 19. Epub 2019 Apr 19.

Department of Biotechnology, Assam University, Silchar, Assam Pin-788011, India; University of Kalyani, Nadia, West Bengal Pin-741235, India. Electronic address:

The global biodiversity of domesticated red jungle fowl (Gallus gallus) is gradually eroding by replacement with commercial poultry breeds and results loss of valuable genetic and physical traits like resistance to disease, extreme environment, etc. posing a threat to the poultry genetic resources. Very fewer reports exist on Indian poultry diversity, especially native chicken of India. Read More

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http://dx.doi.org/10.1016/j.gene.2019.04.051DOI Listing

Nuclease activity decreases the RNAi response in the sweetpotato weevil Cylas puncticollis.

Insect Biochem Mol Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, B-9000, Ghent, Belgium. Electronic address:

RNA interference (RNAi) refers to the process of suppression of gene expression in eukaryotes, which has a great potential for the control of pest and diseases. Unfortunately, the efficacy of this technology is limited or at best variable in some insects. In the African sweet potato weevil (SPW) Cylas puncticollis, a devastating pest that affects the sweet potato production in Sub-Saharan Africa (SSA), the RNAi response was highly efficient when dsRNA was delivered by injection, but it showed a reduced response by oral feeding. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.04.001DOI Listing

Differential expression patterns of sodium potassium ATPase alpha and beta subunit isoforms in mouse brain during postnatal development.

Neurochem Int 2019 Apr 19. Epub 2019 Apr 19.

Ruhr University Bochum, Faculty of Chemistry and Biochemistry, Biochemistry II, Bochum, Germany; Ruhr University Bochum, International Graduate School for Neuroscience, Germany. Electronic address:

The sodium potassium ATPase (Na/K ATPase) is essential for the maintenance of a low intracellular Na and a high intracellular K concentration. Loss of function of the Na/K ATPase due to mutations in Na/K ATPase genes, anoxic conditions, depletion of ATP or inhibition of the Na/K ATPase function using cardiac glycosides such as digitalis, causes a depolarization of the resting membrane potential. While in non-excitable cells, the uptake of glucose and amino acids is decreased if the function of the Na/K ATPase is compromised, in excitable cells the symptoms range from local hyper-excitability to inactivating depolarization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01970186183045
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http://dx.doi.org/10.1016/j.neuint.2019.04.009DOI Listing
April 2019
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Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer.

Life Sci 2019 Apr 19. Epub 2019 Apr 19.

College of Pharmacy, Dalian Medical University, Dalian 116044, China. Electronic address:

Aims: To investigate the antitumor effect of 7-O-geranylquercetin (GQ) combining with survivin siRNA (siSuvi) or IL-10 siRNA (siIL-10) to breast cancer.

Main Methods: Xenograft tumor model was established by subcutaneously inoculating human breast cancer MCF-7 cells in BALB/c nude mice. Transfection efficiency of siRNA mediated by cationic liposome CDO14 in MCF-7 cells and tumor bearing mice was measured by flow cytometer and living imaging sysytem, respectively. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.047DOI Listing

Co-spray-dried urea cross-linked hyaluronic acid and sodium ascorbyl phosphate as novel inhalable dry powder formulation.

J Pharm Sci 2019 Apr 19. Epub 2019 Apr 19.

Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Faculty of Medicine and Health, The University of Sydney, 431 Glebe Point Road, Glebe, NSW 2037, Australia. Electronic address:

The pathogenesis and progression of several lung disorders is propagated by inflammatory and oxidative processes which can be controlled by adjunctive inhaled therapies. The present study aimed to develop an inhalable dry powder formulation consisting of co-spray-dried urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate (SD HA-CL - SAP), a novel combination which was recently shown to possess anti-inflammatory, antioxidant and wound healing properties. Native HA and SAP were co-spray dried (SD HA - SAP) and evaluated as control formulation. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.04.015DOI Listing
April 2019
2 Reads

Recent advances in gelatin-based therapeutics.

Expert Opin Biol Ther 2019 Apr 22. Epub 2019 Apr 22.

a NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7 , Vitoria-Gasteiz 01006 , Spain .

Introduction: Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules. Areas covered: The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. Read More

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http://dx.doi.org/10.1080/14712598.2019.1610383DOI Listing

Involvement of miR-770-5p in trastuzumab response in HER2 positive breast cancer cells.

PLoS One 2019 22;14(4):e0215894. Epub 2019 Apr 22.

Biotechnology Institute, Ankara University, Ankara, Turkey.

miRNAs may play effective roles in breast cancer so modulating their expression levels could have therapeutic benefits. Recent studies have found the combination of miRNA-based therapeutics with conventional drugs as promising. This study aimed to find drug-responsive miRNAs, and explore their anticancer activities in HER2+ breast cancer cells and regulatory role in the trastuzumab response. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215894PLOS

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage.

PLoS Pathog 2019 Apr 22;15(4):e1007625. Epub 2019 Apr 22.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can cause a range of diseases from self-limiting dengue fever to life-threatening dengue hemorrhagic fever and shock syndrome. Thrombocytopenia is a major characteristic observed in both mild and severe dengue disease and is significantly correlated with the progression of dengue severity. Previous studies have shown that DENV nonstructural protein 1 (NS1), which can be secreted into patients' blood, can stimulate immune cells via Toll-like receptor 4 (TLR4) and can cause endothelial leakage. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007625DOI Listing

Prevalence, intensity and associated risk factors of soil transmitted helminth infections: A comparison between Negritos (indigenous) in inland jungle and those in resettlement at town peripheries.

PLoS Negl Trop Dis 2019 Apr 22;13(4):e0007331. Epub 2019 Apr 22.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: Formerly known as the Malaysian hunter gatherers, the Negrito Orang Asli (OA) were heavily dependent on the forest for sustenance and early studies indicated high prevalence of intestinal parasitism. Initiation of a redevelopment program in the 1970s aimed to demarginalize the OA was expected to reduce soil transmitted helminth (STH) infections. Gradually, the OA were relocated to new resettlement areas at the peripheries. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007331DOI Listing

A benchmark-driven approach to reconstruct metabolic networks for studying cancer metabolism.

PLoS Comput Biol 2019 Apr 22;15(4):e1006936. Epub 2019 Apr 22.

Department of Biotechnology, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran.

Genome-scale metabolic modeling has emerged as a promising way to study the metabolic alterations underlying cancer by identifying novel drug targets and biomarkers. To date, several computational methods have been developed to integrate high-throughput data with existing human metabolic reconstructions to generate context-specific cancer metabolic models. Despite a number of studies focusing on benchmarking the context-specific algorithms, no quantitative assessment has been made to compare the predictive performance of these methods. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006936DOI Listing

Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm.

PLoS Comput Biol 2019 Apr 22;15(4):e1006842. Epub 2019 Apr 22.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America.

Many proteins fold into highly regular and repetitive three dimensional structures. The analysis of structural patterns and repeated elements is fundamental to understand protein function and evolution. We present recent improvements to the CE-Symm tool for systematically detecting and analyzing the internal symmetry and structural repeats in proteins. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006842DOI Listing

Recombinant Expression of Zinc Transporter SLC39A6 and Its Functional Antibody Production.

Monoclon Antib Immunodiagn Immunother 2019 Apr;38(2):70-74

1 Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.

Zinc transporter ZIP6 (SLC39A6) or LIV-1 is a protein that belongs to a subfamily of proteins group that displays structural specifications of zinc transporters in the cell membrane. Overexpression of this protein is observed in breast, prostate, and kidney tumor cells. Lately, LIV-1 is a dependable marker for detection of estrogen receptor positive breast cancer, which can be used to detect luminal breast cancer type A. Read More

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http://dx.doi.org/10.1089/mab.2018.0045DOI Listing

Analyses of Livestock-Associated Pan-Genomes Suggest Virulence Is Not Primary Interest in Evolution of Its Genome.

OMICS 2019 Apr;23(4):224-236

1 Department of Animal Behaviour & Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India.

is not only part of normal flora but also an opportunistic pathogen relevant to microbial genomics, public health, and veterinary medicine. In addition to being a well-known human pathogen, causes various infections in economically important livestock animals such as cows, sheep, goats, and pigs. There are very few studies that have examined the pan-genome of or the host-specific strains' pan-genomes. Read More

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http://dx.doi.org/10.1089/omi.2019.0005DOI Listing

Metabolomics-Based Biosignatures of Prostate Cancer in Patients Following Radiotherapy.

OMICS 2019 Apr;23(4):214-223

1 Department of Biochemistry, Cellular and Molecular Biology, School of Medicine, Georgetown University, Washington, District of Columbia.

Metabolomics offers new promise for research on prostate cancer (PCa) and its personalized treatment. Metabolomic profiling of radiation-treated PCa patients is particularly important to reveal their new metabolomic status, and evaluate the radiation effects. In addition, bioinformatics-integrated metabolomics-based approaches for disease profiling and assessment of therapy could help develop precision biomarkers in a context of PCa. Read More

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http://dx.doi.org/10.1089/omi.2019.0006DOI Listing

Exposure assessment and risk characterization of aflatoxins intake through consumption of maize products in the adult populations of Serbia, Croatia and Greece.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Apr 22:1-12. Epub 2019 Apr 22.

a Department of Food Safety and Quality Management , Faculty of Agriculture, University of Belgrade , Belgrade , Republic of Serbia.

The main objective of this research was to perform an exposure assessment of aflatoxins intake through consumption of maize products in Serbia, Croatia, and Greece. Food consumption survey of maize-based products has been performed during 2017 in the three countries with at least 1,000 interviewees per country covering their dietary habits and body weight. Values for the concentration of aflatoxins were extracted from available research published in the last ten years. Read More

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http://dx.doi.org/10.1080/19440049.2019.1600748DOI Listing

Chemical constituents and HRESI-MS analysis of an Algerian endemic plant - Verbascum atlanticum batt. - extracts and their antioxidant activity.

Nat Prod Res 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Unité de recherche: Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine , Constantine , Algérie.

This is the first report on the phytochemistry and antioxidant activity of ethyl acetate and n- butanol extracts from an Algerian endemic plant Verbascum atlanticum Batt. (Scrophulariaceae). Both extracts were subjected to a phytochemical study by semi-preparative HPLC, which led to the isolation and identification of nine compounds: methyl linolenate (1), methyl linoleate (2), Phytol-1(3), Martynoside (4), Isomartynoside (5), Cis-martynoside (6), Ilwensisaponin C (7), Ilwensisaponin B (8), Ilwensisaponin A (9). Read More

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http://dx.doi.org/10.1080/14786419.2019.1602829DOI Listing

Combination of Human Umbilical Vein Endothelial Cell Vaccine and Docetaxel Generates Synergistic Anti-Breast Cancer Effects.

Cancer Biother Radiopharm 2019 Apr 22. Epub 2019 Apr 22.

1 The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, P.R. China.

A human umbilical vein endothelial cell (HUVEC) vaccine is a promising anti-angiogenesis therapy, but the modest therapeutic antitumor efficacy restricts its clinical use. Preclinical evidence supports the combination of antiangiogenic agents and chemotherapy for cancer treatment. In the present study, docetaxel (DOC) was combined with HUVEC vaccine to develop a HUVEC-DOC treatment regime. Read More

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http://dx.doi.org/10.1089/cbr.2018.2721DOI Listing

Curcumin-Synthetic Analogs Library Screening by Docking and Quantitative Structure-Activity Relationship Studies for AXL Tyrosine Kinase Inhibition in Cancers.

J Comput Biol 2019 Apr 22. Epub 2019 Apr 22.

The Biotechnology Lab (MedBiotech), BioInova Research center, Rabat Medical and Pharmacy School, Mohammed V University in Rabat, Rabat, Morocco.

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https://www.liebertpub.com/doi/10.1089/cmb.2019.0052
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http://dx.doi.org/10.1089/cmb.2019.0052DOI Listing
April 2019
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Eudesmane Glycosides from Ambrosia artemisiifolia (Common Ragweed) as Potential Neuroprotective Agents.

J Nat Prod 2019 Apr 22. Epub 2019 Apr 22.

Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.

In Alzheimer's disease, amyloid-β (Aβ) accumulation in the brain results in neuronal cell death and is one of the major causes of dementia. Because the current therapeutic agents are not yet sufficiently effective or safe, there have been attempts to find new neuroprotective chemicals against Aβ-induced cytotoxicity. A 70% EtOH extract of whole plants of Ambrosia artemisiifolia (common ragweed) was selected after the screening of a natural extract library. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00841DOI Listing

Stabilizing Terminal Ni(III)-Hydroxide Complex Using NNN-Pincer Ligands: Synthesis and Characterization.

Inorg Chem 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry , Indian Institute of Technology Bombay , Powai - 400076 , Mumbai , Maharashtra , India.

The reaction of [Ni(COD)] (COD; cyclooctadiene) in THF with the NNN-pincer ligand bis(imino)pyridyl (L) reveals a susceptibility to oxidation in an inert atmosphere ([O] level <0.5 ppm), resulting in a transient Ni:dioxygen adduct. This reactive intermediate abstracts a hydrogen atom from THF and stabilizes an uncommon Ni(III) complex. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00466DOI Listing

A2ML1 and otitis media: novel variants, differential expression and relevant pathways.

Hum Mutat 2019 Apr 22. Epub 2019 Apr 22.

Department of Otolaryngology, University of Colorado School of Medicine (CUSOM), Aurora, Colorado, USA.

A genetic basis for otitis media is established, however the role of rare variants in disease etiology is largely unknown. Previously a duplication variant within A2ML1 was identified as a significant risk factor for otitis media in an indigenous Filipino population and in US children. In this report exome and Sanger sequencing was performed using DNA samples from the indigenous Filipino population, Filipino cochlear implantees, US probands, and Finnish and Pakistani families with otitis media. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.23769
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http://dx.doi.org/10.1002/humu.23769DOI Listing

Projecting impacts of global climate and land-use scenarios on plant biodiversity using compositional-turnover modelling.

Glob Chang Biol 2019 Apr 22. Epub 2019 Apr 22.

CSIRO Land and Water, Building 101, Black Mountain Laboratories, Clunies Ross St., Canberra, ACT, 2601, Australia.

Nations have committed to ambitious conservation targets in response to accelerating rates of global biodiversity loss. Anticipating future impacts is essential to inform policy decisions for achieving these targets, but predictions need to be of sufficiently high spatial resolution to forecast the local effects of global change. As part of the intercomparison of biodiversity and ecosystem services models of the IPBES, we present a fine-resolution assessment of trends in the persistence of global plant biodiversity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gcb.14663
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http://dx.doi.org/10.1111/gcb.14663DOI Listing
April 2019
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The MYB transcription factor EMA1 stimulates emission of methyl anthranilate from Medicago truncatula hairy roots.

Plant J 2019 Apr 22. Epub 2019 Apr 22.

Ghent University, Department of Plant Biotechnology and Bioinformatics, Technologiepark 71, B-9052, Ghent, Belgium.

Plants respond to herbivore or pathogen attacks by activating specific defense programs that include the production of bioactive specialized metabolites to eliminate or deter the attackers. Volatiles play an important role in the interaction of a plant with its environment. Through transcript profiling of jasmonate-elicited Medicago truncatula cells we identified Emission of Methyl Anthranilate (EMA) 1, a MYB transcription factor that is involved in the emission of the volatile compound methyl anthranilate when expressed in M. Read More

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http://dx.doi.org/10.1111/tpj.14347DOI Listing

Administration of enrofloxacin during late pregnancy failed to induce lesions in the resulting newborn foals.

Equine Vet J 2019 Apr 22. Epub 2019 Apr 22.

Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.

Background: A recent study demonstrated that enrofloxacin and ciprofloxacin cross the equine placenta without causing gross cartilage or tendon lesions in the 9-month foetus; however, long-term effects of in utero fluoroquinolone exposure are unknown.

Objectives: To assess effects of foetal exposure to enrofloxacin on the resulting foal's cartilage and tendon strength.

Study Design And Methods: Healthy mares at 280 days' gestation were allocated into four groups: untreated (n = 5), therapeutic treatment (7. Read More

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http://dx.doi.org/10.1111/evj.13131DOI Listing

Structures of a highly variable cell-wall anchored protein-encoding the spj gene from ST8/SCCmecIVl community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA/J) isolated from 2003 onwards: An indicator of a strongly invasive pathotype.

Microbiol Immunol 2019 Apr 22. Epub 2019 Apr 22.

Department of Epidemiology, Genomics, and Evolution, International Medical Education and Research Center, Niigata, Japan.

The cell wall-anchored protein-encoding spj gene on staphylococcal cassette chromosome mec IVl (SCCmecIVl) varied in size due to its 22- and 86-amino acid (aa) repeat domains. Of the two repeats, the 22-aa repeats were more flexible, comprising three 11-aa units, and were classified into three groups with eleven types. The 11/22-aa repeats were longer in bulluos impetigo cases, shorter in invasive cases, and absent in a fatal case, with the last one being rapidly diagnosed by PCR. Read More

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http://dx.doi.org/10.1111/1348-0421.12684DOI Listing

Arabinose biosynthesis is critical for salt stress tolerance in Arabidopsis.

New Phytol 2019 Apr 22. Epub 2019 Apr 22.

CAS Center for Excellence in Molecular Plant Sciences, Shanghai Center for Plant Stress Biology, Chinese Academy of Sciences, Shanghai, 201602, China.

The capability to maintain cell wall integrity is critical for plants to adapt to unfavorable conditions. L-arabinose (Ara) is a constituent of several cell wall polysaccharides and many cell wall-localized glycoproteins, but so far the contribution of Ara metabolism to abiotic stress tolerance is still poorly understood. Here, we report that mutations in the MUR4 (also known as HSR8) gene, which is required for the biosynthesis of UDP-Arap in Arabidopsis, lead to a reduced root elongation under high concentrations of NaCl, KCl, NaNO , or KNO . Read More

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http://dx.doi.org/10.1111/nph.15867DOI Listing

Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A-E from the Wrinkled Peach Mushroom, Rhodotus palmatus.

Org Lett 2019 Apr 22. Epub 2019 Apr 22.

Department of Microbial Drugs , Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7 , 38124 Braunschweig , Germany.

Rhodatin (1), a meroterpenoid featuring a unique pentacyclic scaffold with both spiro and spiroketal centers, and five unusual acorane-type sesquiterpenoids, named rhodocoranes A-E (2-6, respectively), are the first natural products isolated from the basidiomycete Rhodotus palmatus. Their structures were elucidated by two-dimensional NMR experiments and HRESIMS, while the absolute configuration of the substance family was determined by Mosher's method utilizing 2. Rhodatin strongly inhibited hepatitis C virus, whereas 4 displayed cytotoxicity and selective antifungal activity. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01017DOI Listing

Gas-Phase Deprotonation of Benzhydryl Cations: Carbene Basicity, Multiplicity, and Rearrangements.

J Org Chem 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry and Chemical Biology , Rutgers, The State University of New Jersey , New Brunswick , New Jersey 08901 , United States.

Many fundamental properties of carbenes, particularly basicity, remain poorly understood. Herein, an experimental and computational examination of the deprotonation of a series of benzhydryl cations has been undertaken. These studies represent the first attempt at providing experimental values for diarylcarbene basicities. Read More

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http://dx.doi.org/10.1021/acs.joc.9b00496DOI Listing

CARD9 protects lung cancer development by suppressing the expansion of myeloid-derived suppressor cells and IDO production.

Int J Cancer 2019 Apr 22. Epub 2019 Apr 22.

The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210093, China.

Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor protein and highly expressed in myeloid cells. Our previous study demonstrates a critical protective effect of CARD9 in the development of colitis-associated colon cancer. Nevertheless, the effect of CARD9 in lung cancer is still unclear. Read More

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http://dx.doi.org/10.1002/ijc.32355DOI Listing

Polycomb complex mediated epigenetic reprogramming alters TGF-β signaling via a novel EZH2/miR-490/TGIF2 axis thereby inducing migration and EMT potential in glioblastomas.

Int J Cancer 2019 Apr 22. Epub 2019 Apr 22.

Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi- 110016, IN.

Recent advancement in understanding cancer etiology has highlighted epigenetic deregulation as an important phenomenon leading to poor prognosis in Glioblastoma (GBM). Polycomb Repressive Complex 2 (PRC2) is one such important epigenetic modifier reportedly altered in GBM. However, its defined mechanism in tumorigenesis still remains elusive. Read More

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http://dx.doi.org/10.1002/ijc.32360DOI Listing

Cytotoxicity and bioadhesive properties of poly--isopropylacrylamide hydrogel.

Heliyon 2019 Apr 9;5(4):e01474. Epub 2019 Apr 9.

Department of Molecular Biology, National University of Río Cuarto-CONICET, National Route N° 36, 601 Km, Rio Cuarto, X5804ZAB, Argentina.

Several hydrogel surfaces present properties that simulate the mechanical and physicochemical features of extracellular matrix (ECM), providing a platform that mimic the native cellular milieus. Poly--isopropylacrylamide (PNIPAM) hydrogels are receiving attention in biomedical field due to their thermosensibility and soft texture. However, more extensive biocompatibility and cellular interactions studies with cell lines are needed. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458465PMC

An update on carbohydrases: growth performance and intestinal health of poultry.

Heliyon 2019 Apr 6;5(4):e01437. Epub 2019 Apr 6.

National Institute for Biotechnology and Genetic Engineering (NIBGE), Jhang Road, Faisalabad, Pakistan.

Poultry is an imperative domesticated livestock species that provides high quality protein and micronutrients as meat and eggs. In poultry production, feed is the single major input constituting 70-75% of total production cost. Feed mainly consists of cereal grains, those provide energy to the birds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183653
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http://dx.doi.org/10.1016/j.heliyon.2019.e01437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454264PMC
April 2019
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CRISPR-interference-based modulation of mobile genetic elements in bacteria.

Synth Biol (Oxf) 2019 15;4(1):ysz008. Epub 2019 Mar 15.

Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.

Spontaneous mutagenesis of synthetic genetic constructs by mobile genetic elements frequently results in the rapid loss of engineered functions. Previous efforts to minimize such mutations required the exceedingly time-consuming manipulation of bacterial chromosomes and the complete removal of insertional sequences (ISes). To this aim, we developed a single plasmid-based system (pCRIS) that applies CRISPR-interference to inhibit the transposition of bacterial ISes. Read More

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http://dx.doi.org/10.1093/synbio/ysz008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462304PMC

RNA profile of control and nicotine treated Murine Leydig single cell represented in TPM data.

Data Brief 2019 Jun 27;24:103825. Epub 2019 Mar 27.

School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, PR China.

Data provided in this article is RNA profile represented in RPKM and RPKM based TPM value for the research article titled Nicotine inhibits Murine Leydig cell differentiation and maturation via regulating Hedgehog signal pathway Jiajie et al., 2019. Nicotine treatment changes the RNA profile of Murine Leydig cells. Read More

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http://dx.doi.org/10.1016/j.dib.2019.103825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454091PMC

First Description of Macrolide-Resistant in Adults with Community-Acquired Pneumonia in Italy.

Biomed Res Int 2019 17;2019:7168949. Epub 2019 Mar 17.

Department of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy.

Background: is a common cause of community-acquired pneumonia (CAP). This cross-sectional study aimed to determine the prevalence of macrolide-resistant strains in a convenience series of 234 adult hospitalised and nonhospitalised subjects with a diagnosis of CAP in January 2013 to April 2015 in South Italy.

Methods: Respiratory samples were subjected to real-time PCR. Read More

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http://dx.doi.org/10.1155/2019/7168949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441498PMC

Influence of Mineral Supplementation on the Results from Analysis of Flavonol Glycoside Content in Dietary Supplements.

Prev Nutr Food Sci 2019 Mar 6;24(1):75-83. Epub 2018 Nov 6.

Department of Food Science and Biotechnology, Chungbuk National University, Chungbuk 28644, Korea.

Flavonoids are a major component of extract (GBE). Several studies have investigated chelate formation and the redox reaction between flavonoids and metal ions; however, the effect of mineral supplements on the results from the analysis of the flavonol glycoside content in products containing GBE dietary supplement remains unknown. In this study, the effects of commonly used mineral supplements on the recovery of quercetin from GBE-containing dietary supplements were investigated using conventional methods of flavonol glycoside determination. Read More

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http://dx.doi.org/10.3746/pnf.2019.24.1.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456232PMC
March 2019
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Antidiarrheal, Analgesic, and Anthelmintic Activities of Honeys in the Sundarbans Mangrove Forest, Bangladesh.

Prev Nutr Food Sci 2019 Mar 31;24(1):49-55. Epub 2019 Mar 31.

Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh.

This study evaluated the antidiarrheal, analgesic, and anthelmintic activities of honey samples from the Sundarbans mangrove forest of Bangladesh. Composite raw honey (RH), and its diethyl ether (DEH), ethanol (ETH), methanol (MEH), and distilled water (DWH) fractions were investigated. RH and its fractions strongly inhibited castor oil-induced diarrheal episodes in mice at a concentration of 250 mg/kg body weight (b. Read More

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http://dx.doi.org/10.3746/pnf.2019.24.1.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456236PMC

Heavy metals accumulation from sewage sludge in the Nile tilapia (Trewavas, 1983) during a sludge-earthworm-fish short-term cycling.

Ital J Food Saf 2019 Mar 19;8(1):7257. Epub 2019 Mar 19.

Biotechnology Research Center, NIETCR, Al Neelain University, Khartoum.

Municipal sewage sludge from waste-water treatment is an important nutritional source for sustainable agriculture. Here, we report on the assessment of the accumulation of heavy metals in Nile tilapia (Trewavas 1983) fed on earthworms reared on soil treated with different concentrations of sewage sludge (25% and 100%) during sludge-earthworm-fish short-term cycling. In this short-term cycling the Nile tilapia collected from the White Nile were chosen as final consumers, whereas the earthworms reared on loam soil mixed with different ratios of sludge were used as a feed for the final consumers. Read More

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http://dx.doi.org/10.4081/ijfs.2019.7257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452095PMC

Optimization of solvent-free enzymatic esterification in eutectic substrate reaction mixture.

Biotechnol Rep (Amst) 2019 Jun 2;22:e00333. Epub 2019 Apr 2.

DECHEMA Research Institute, Industrial Biotechnology, Theodor-Heuss-Allee 25, 60486, Frankfurt a.M., Germany.

The lipase catalyzed esterification of (-)-menthol and lauric acid (LA) was studied in a eutectic mixture formed by both substrates((-)-menthol:LA 3:1, mol/mol). No additional reaction solvent was necessary, since the (-)-menthol:LA deep eutectic solvent (DES) acts as combined reaction medium and substrate pool. Therefore, the esterification is conducted under solvent-free conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2215017X183032
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http://dx.doi.org/10.1016/j.btre.2019.e00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453777PMC
June 2019
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Food waste accounting methodologies: Challenges, opportunities, and further advancements.

Glob Food Sec 2019 Mar;20:93-100

European Commission, Joint Research Centre (JRC), Via E. Fermi, 2749, 21027 Ispra, VA, Italy.

About one third of the food produced globally is wasted along the food chain, representing a burden for the environment and an inefficiency of the food system. Tackling food waste is a priority on the global political agenda to guarantee food security. Defining a methodology for food waste quantification is key to monitoring progress towards the achievement of reduction targets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22119124173015
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http://dx.doi.org/10.1016/j.gfs.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472538PMC

Comparing the Potential of Near- and Mid-Infrared Spectroscopy in Determining the Freshness of Strawberry Powder from Freshly Available and Stored Strawberry.

J Anal Methods Chem 2019 17;2019:2360631. Epub 2019 Mar 17.

College of Agriculture & Biotechnology/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Zijingang Campus, Hangzhou 310058, China.

The quality of strawberry powder depends on the freshness of the fruit that produces the powder. Therefore, identifying whether the strawberry powder is made from freshly available, short-term stored, or long-term stored strawberries is important to provide consumers with quality-assured strawberry powder. Nevertheless, such identification is difficult by naked eyes, as the powder colours are very close. Read More

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http://dx.doi.org/10.1155/2019/2360631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441537PMC

Exosomes from N-Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non-N-Myc amplified cells: implications of intra-tumour heterogeneity.

J Extracell Vesicles 2019 11;8(1):1597614. Epub 2019 Apr 11.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.

Neuroblastoma accounts for 15% of childhood cancer mortality. Amplification of the oncogene N-Myc is a well-established poor prognostic marker for neuroblastoma. Whilst N-Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of N-Myc in the aggressiveness of the disease is poorly understood. Read More

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http://dx.doi.org/10.1080/20013078.2019.1597614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461098PMC