56,759 results match your criteria Biosensors & Bioelectronics [Journal]


Current and future envision on developing biosensors aided by 2D molybdenum disulfide (MoS) productions.

Biosens Bioelectron 2019 Mar 6;132:248-264. Epub 2019 Mar 6.

Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, 01000 Kangar, Perlis, Malaysia.

Two-dimensional (2D) layered nanomaterials have triggered an intensive interest due to the fascinating physiochemical properties with the exceptional physical, optical and electrical characteristics that transpired from the quantum size effect of their ultra-thin structure. Among the family of 2D nanomaterials, molybdenum disulfide (MoS) features distinct characteristics related to the existence of direct energy bandgap, which significantly lowers the leakage current and surpasses other 2D materials. In this overview, we expatiate the novel strategies to synthesize MoS that cover techniques such as liquid exfoliation, chemical vapour deposition, mechanical exfoliation, hydrothermal reaction, and Van Der Waal epitaxial growth on the substrate. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.005DOI Listing

Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum.

Cereb Cortex 2019 Mar 16. Epub 2019 Mar 16.

Sorbonne Université, CNRS, Biological Adaptation and Ageing, Paris, France.

The calcium-regulated phosphodiesterase 1 (PDE1) family is highly expressed in the brain, but its functional role in neurones is poorly understood. Using the selective PDE1 inhibitor Lu AF64196 and biosensors for cyclic nucleotides including a novel biosensor for cGMP, we analyzed the effect of PDE1 on cAMP and cGMP in individual neurones in brain slices from male newborn mice. Release of caged NMDA triggered a transient increase of intracellular calcium, which was associated with a decrease in cAMP and cGMP in medium spiny neurones in the striatum. Read More

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http://dx.doi.org/10.1093/cercor/bhz041DOI Listing

Isolation of novel quorumsensing active bacteria from microbial mats in Shark Bay Australia.

FEMS Microbiol Ecol 2019 Mar 16. Epub 2019 Mar 16.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.

Quorum sensing is a potent system of genetic control allowing phenotypes to be coordinated across localized communities. In this study, quorum sensing systems in Shark Bay microbial mats were delineated using a targeted approach analyzing whole mat extractions as well as the creation of an isolate library. A library of 165 isolates from different mat types were screened using the AHL biosensor E. Read More

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http://dx.doi.org/10.1093/femsec/fiz035DOI Listing

Consumer electronics devices for DNA genotyping based on loop-mediated isothermal amplification and array hybridisation.

Talanta 2019 Jun 10;198:424-431. Epub 2019 Feb 10.

Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, E46022 Valencia, Spain; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Valencia, Spain; Unidad Mixta UPV-La Fe, Nanomedicine and Sensors, IIS La Fe, Valencia, Spain.

Consumer electronic technologies offer practical performances to develop compact biosensing systems intended for the point-of-care testing of DNA biomarkers. Herein a discrimination method for detecting single nucleotide polymorphisms, based on isothermal amplification and on-chip hybridisation, was developed and integrated into user-friendly optical devices: e.g. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.124DOI Listing

Cascade signal amplified assay of nucleic acids based on entropy-driven amplification strategy and Mg-dependent DNAzyme cleavage.

Talanta 2019 Jun 4;198:179-184. Epub 2019 Feb 4.

College of Life Science, South China Normal University, Guangzhou 510631, China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. Electronic address:

Nucleic acids-based biosensors are extremely important in modern life sciences and have been widely used for the detection of many biomarkers of disease and extensively applied in many fields, such as medical analysis, gene therapy, and pathogen determination. Therefore, it is necessary to develop some sensitive and selective methods for rapid detection of nucleic acids. In this work, an ultrasensitive and non-enzyme electrochemical biosensor has been developed for nucleic acids detection based on entropy-driven amplification (EDA) strategy and Mg-dependent DNAzyme cleavage method. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.02.008DOI Listing

Colorimetric determination of total protein content in serum based on the polydopamine/protein adsorption competition on microplates.

Talanta 2019 Jun 28;198:15-22. Epub 2019 Jan 28.

Department of Chemistry 'Ugo Schiff', University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Italy. Electronic address:

We report a facile, low-cost and safe analytical method for estimation of total protein content, even in complex matrix like human serum, by exploiting the competition between proteins and polydopamine (PDA) for surface binding. The surface coating has been examined by using a microplate reader taking the advantage of the PDA absorbance in the visible region, obtaining new insights into the modelling of polydopamine deposition and polymer/protein adsorption competition. This is helpful for rational development of imprinted biosensors, and potentially offering a with broad applications ranging from diagnostic tools in medicine to food analysis. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.095DOI Listing

Enzyme-Based Electrochemical Biosensors for Microfluidic Platforms to Detect Pharmaceutical Residues in Wastewater.

Biosensors (Basel) 2019 Mar 15;9(1). Epub 2019 Mar 15.

Department of Electrical and Electronics Engineering, Universidad de los Andes, Cra. 1E No. 19a-40, Bogotá, DC 111711, Colombia.

Emerging water pollutants such as pharmaceutical contaminants are suspected to induce adverse effects to human health. These molecules became worrisome due to their increasingly high concentrations in surface waters. Despite this alarming situation, available data about actual concentrations in the environment is rather scarce, as it is not commonly monitored or regulated. Read More

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http://dx.doi.org/10.3390/bios9010041DOI Listing

Separation and Detection of and Using a Microfluidic Device Integrated with an Optical Fibre.

Biosensors (Basel) 2019 Mar 14;9(1). Epub 2019 Mar 14.

Department of Chemical and Environmental Engineering, University Putra Malaysia, Selangor 43400, Malaysia.

This paper describes the development of an integrated system using a dry film resistant (DFR) microfluidic channel consisting of pulsed field dielectrophoretic field-flow-fractionation (DEP-FFF) separation and optical detection. The prototype chip employs the pulse DEP-FFF concept to separate the cells ( and ) from a continuous flow, and the rate of release of the cells was measured. The separation experiments were conducted by changing the pulsing time over a pulsing time range of 2⁻24 s and a flow rate range of 1. Read More

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https://www.mdpi.com/2079-6374/9/1/40
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http://dx.doi.org/10.3390/bios9010040DOI Listing
March 2019
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Recent advances in thread-based microfluidics for diagnostic applications.

Biosens Bioelectron 2019 Mar 8;132:171-185. Epub 2019 Mar 8.

School of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, China. Electronic address:

Over the past decades, researchers have been seeking attractive substrate materials to keep microfluidics improving to outbalance the drawbacks and issues. Cellulose substrates, including thread, paper and hydrogels are alternatives due to their distinct structural and mechanical properties for a number of applications. Thread have gained considerable attention and become promising powerful tool due to its advantages over paper-based systems thus finds numerous applications in the development of diagnostic systems, smart bandages and tissue engineering. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.009DOI Listing

Nanoplasmonic swarm biosensing using single nanoparticle colorimetry.

Biosens Bioelectron 2019 Mar 4;132:162-170. Epub 2019 Mar 4.

Department of Bioengineering, University of California, Los Angeles, CA 90095, USA. Electronic address:

We demonstrate a swarm biosensing platform that detects analyte based on the change in plasmonic signal from thousands of single nanoparticles sensors, leading to increased quantitative accuracy. Following dark field microscopy, we perform computational image registration and analyses to compile the hue change from thousands of single gold nanoparticles acting as individual quantitative biosensors. This platform demonstrated a limit of detection of 10 pM with a dynamic range of at least 4 orders of magnitude in buffer solution, and the successful detection of c-reactive protein (CRP) in serum compatible with 3-tier clinical cutoffs within a 10-fold difference without the need for a blocking step. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193017
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http://dx.doi.org/10.1016/j.bios.2019.02.056DOI Listing
March 2019
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Construction of ligand assay systems by protein-based semisynthetic biosensors.

Curr Opin Chem Biol 2019 Mar 12;50:10-18. Epub 2019 Mar 12.

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. Electronic address:

Proteins as causative agents of diseases such as cancers, diabetes and neurological disorders are attractive drug targets. For developing chemicals selectively acting on key disease-causing proteins, one useful concept is the direct conversion of such target proteins into biosensors. This approach provides ligand-binding assay systems based on protein-based biosensors, which can quantitatively evaluate interactions between the protein and a specific ligand in many environments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13675931183017
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http://dx.doi.org/10.1016/j.cbpa.2019.02.011DOI Listing
March 2019
1 Read

Introducing three new ABC Editors.

Anal Bioanal Chem 2019 Mar 14. Epub 2019 Mar 14.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Annunziata, 98168, Messina, Italy.

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http://dx.doi.org/10.1007/s00216-019-01706-4DOI Listing

A palladium-catalyzed multi-component annulation approach towards the synthesis of phenanthrenes.

Org Biomol Chem 2019 Mar 15. Epub 2019 Mar 15.

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, P. R. China.

An efficient palladium-catalyzed three-component cascade reaction has been developed for the facile construction of phenanthrene frameworks. The transformation is driven by a controlled reaction sequence of Suzuki-Miyaura coupling followed by the insertion of alkynes, and finally, annulation to yield phenanthrene derivatives via C-H activation. This methodology is able to accommodate a variety of substrates and affords the anticipated products in good to excellent yields. Read More

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http://dx.doi.org/10.1039/c9ob00228fDOI Listing

An Observational Study With the Janssen Autism Knowledge Engine (JAKE) in Individuals With Autism Spectrum Disorder.

Front Neurosci 2019 27;13:111. Epub 2019 Feb 27.

Neuroscience Therapeutic Area, Janssen Research & Development, Pennington, NJ, United States.

The Janssen Autism Knowledge Engine (JAKE®) is a clinical research outcomes assessment system developed to more sensitively measure treatment outcomes and identify subpopulations in autism spectrum disorder (ASD). Here we describe JAKE and present results from its digital phenotyping (My JAKE) and biosensor (JAKE Sense) components. An observational, non-interventional, prospective study of JAKE in children and adults with ASD was conducted at nine sites in the United States. Read More

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http://dx.doi.org/10.3389/fnins.2019.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402449PMC
February 2019

Cell-free expression, purification and characterization of Drosophila melanogaster odorant receptor OR42a and its co-receptor.

Protein Expr Purif 2019 Mar 11;159:27-33. Epub 2019 Mar 11.

Department of Biology and Chemistry, National University of Defense Technology, Changsha, 410000, Hunan, China. Electronic address:

Olfactory receptors (OR), a group of classic membrane proteins, plays a vital role in insect reproduction and acclimatization. Deciphering the molecular mechanism of insect olfaction could enhance pest control and environmental protection. Studies on ORs have faced a major bottleneck due to the notoriously strong hydrophobicity of ORs, which results in difficult expression in heterologous cell systems. Read More

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http://dx.doi.org/10.1016/j.pep.2019.03.001DOI Listing

Biotin interference in immunoassays based on biotin-strept(avidin) chemistry: An emerging threat.

Biotechnol Adv 2019 Mar 11. Epub 2019 Mar 11.

University College Cork, Irish Separation Science Cluster ISSC Ireland, Innovative Chromatography Group, Western Rd, Cork T12 YN60, Ireland; University College Cork, School of Chemistry, College Road, Cork T12 YN60, Ireland.

Biotinylated antibodies/antigens are currently used in many immunoassay formats in clinical settings for diversified analytes and biomarkers to offer high detection selectivity and sensitivity. Biotin cannot be synthesized by mammals and must be taken as an essential supplement. Normal intake of biotin from various foods and milk causes no effect on the streptavidin/biotin-based immunoassays. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.007DOI Listing

Development of an Impedimetric Aptasensor for Label Free Detection of Patulin in Apple Juice.

Molecules 2019 Mar 13;24(6). Epub 2019 Mar 13.

BAE: Biocapteurs-Analyses-Environnement, Universite de Perpignan Via Domitia, 52 Avenue Paul Alduy, 66860 Perpignan CEDEX, France.

In the present work, an aptasensing platform was developed for the detection of a carcinogenic mycotoxin termed patulin (PAT) using a label-free approach. The detection was mainly based on a specific interaction of an aptamer immobilized on carbon-based electrode. A long linear spacer of carboxy-amine polyethylene glycol chain (PEG) was chemically grafted on screen-printed carbon electrodes (SPCEs) via diazonium salt in the aptasensor design. Read More

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http://dx.doi.org/10.3390/molecules24061017DOI Listing

Improvement of High Affinity and Selectivity on Biosensors Using Genetically Engineered Phage by Binding Isotherm Screening.

Viruses 2019 Mar 12;11(3). Epub 2019 Mar 12.

Research Center for Energy Convergence and Technology, Pusan National University, Busan 46241, Korea.

The genetically engineered M13 bacteriophage (M13 phage), developed via directed evolutionary screening process, can improve the sensitivity of sensors because of its selective binding to a target material. Herein, we propose a screening method to develop a selective and sensitive bioreporter for toxic material based on genetically engineered M13 phage. The paraquat (PQ)-binding M13 phage, developed by directed evolution, was used. Read More

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http://dx.doi.org/10.3390/v11030248DOI Listing

Iridium oxide (IV) nanoparticle-based lateral flow immunoassay.

Biosens Bioelectron 2019 Feb 28;132:132-135. Epub 2019 Feb 28.

Nanobioelectronics & Biosensors Group, Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193 Bellaterra, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), P. Lluís Companys 23, 08010 Barcelona, Spain. Electronic address:

Lateral flow biosensors are paper-based devices that allow the detection of different types of analytes with quickness, robustness and selectivity, without leaving behind paper sensors benefits as low-cost, recyclability and sustainability. Nanomaterials have been widely reported in lateral flow biosensors, offering new sensing strategies based on optical or electrical detection techniques. Looking for other advantageous nanomaterials, we propose for the first time the use of iridium oxide (IV) nanoparticles in lateral flow assays for the detection of human immunoglobulin as a model protein. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.049DOI Listing
February 2019

Poly(lactic) acid/carbon nanotube composite microneedle arrays for dermal biosensing.

Anal Chem 2019 Mar 14. Epub 2019 Mar 14.

Minimally invasive, reliable and low-cost in vivo biosensors that enable real-time detection and monitoring of clinically rele-vant molecules and biomarkers can significantly improve patient healthcare. Microneedle array (MNA) based electrochemi-cal sensors offer exciting prospects in this respect, as they can sample directly from the skin. However, their acceptability is dependent on developing a highly scalable and cost-effective fabrication strategy. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b04980DOI Listing

[Von Willebrand disease in the elderly].

Rev Prat 2018 Dec;68(10):1125-1131

Service d'hématologie biologique, site constitutif du centre de référence maladie rare de la maladie de Willebrand, hôpital Lariboisière, AP-HP, Paris, France.

Von Willebrand disease in the elderly. Von Willebrand disease (VWD) is a rare inherited haemorrhagic disorder, the prevalence of symptomatic individuals is around 1/10 000. Von Willebrand factor level increases with advanced age, explaining a lower frequency and a lower severity of cutaneous haemorrhagic symptoms with aging. Read More

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December 2018

Wrinkled two-dimensional ultrathin Cu(ii)-porphyrin framework nanosheets hybridized with polypyrrole for flexible all-solid-state supercapacitors.

Dalton Trans 2019 Mar 14. Epub 2019 Mar 14.

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, P. R. China.

Two-dimensional (2D) metal porphyrin frameworks (MPFs) with a π-conjugated skeleton, high surface area, and more accessible active sites have been applied as active materials for supercapacitors, but the poor electrical conductivity limits the enhancement of electrochemical performance. Moreover, MPF-based flexible supercapacitors have been rarely reported. Here, for the first time, we fabricated wrinkled 2D ultrathin 5,10,15,20-tetrakis(4-carboxylphenyl)porphyrin copper(ii) (Cu-TCPP) nanosheets through the surfactant-assisted synthetic method. Read More

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http://dx.doi.org/10.1039/c8dt05069dDOI Listing

Directly functionalized cucurbit[7]uril as a biosensor for the selective detection of protein interactions by 129Xe hyperCEST NMR.

Chemistry 2019 Mar 13. Epub 2019 Mar 13.

UNITED STATES.

Advancement of hyperpolarized 129Xe MRI technology toward clinical settings demonstrates the considerable interest in this modality for diagnostic imaging. The number of contrast agents, termed biosensors, for 129Xe MRI that respond to specific biological targets, has grown and diversified. Directly functionalized xenon-carrying macrocycles, such as the large family of cryptophane-based biosensors, are good for localization-based imaging and provide contrast before and after binding events occur. Read More

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http://dx.doi.org/10.1002/chem.201900610DOI Listing

Enhanced His@AuNCs oxidase-like activity by reduced graphene oxide and its application for colorimetric and electrochemical detection of nitrite.

Anal Bioanal Chem 2019 Mar 13. Epub 2019 Mar 13.

Key Laboratory of Bioelectrochemistry & Environmental of Gansu Province, Lanzhou, 730070, Gansu, China.

Enzyme-mimicking (nanozyme)-based biosensors are attractive owing to their unique catalytic efficiency, multifunctionality, and tunable activity, but examples of oxidase-like nanozymes are quite rare. Herein, we demonstrated that histidine-capped gold nanoclusters (His@AuNCs) possessed intrinsic oxidase-like activity, which could directly oxidize 3,3',5,5'-tetramethylbenzidine (TMB) to blue colored ox-TMB without HO. The assembly of reduced graphene oxide (RGO) with His@AuNCs could further improve its oxidase-like activity and the His@AuNCs/RGO nanocomposites had a lower Michaelis constant (K) and higher catalytic constant (K) for TMB oxidation. Read More

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http://dx.doi.org/10.1007/s00216-019-01655-yDOI Listing

True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study.

BMJ 2019 Mar 13;364:l729. Epub 2019 Mar 13.

Coronary Research Group, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Objective: To determine the distribution, and specifically the true 99th centile, of high sensitivity cardiac troponin I (hs-cTnI) for a whole hospital population by applying the hs-cTnI assay currently used routinely at a large teaching hospital.

Design: Prospective, observational cohort study.

Setting: University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, between 29 June 2017 and 24 August 2017. Read More

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http://dx.doi.org/10.1136/bmj.l729DOI Listing

Design and Manufacturing of a Disposable, Cyclo-Olefin Copolymer, Microfluidic Device for a Biosensor .

Sensors (Basel) 2019 Mar 7;19(5). Epub 2019 Mar 7.

Institut für Mikrosensoren, -Aktoren und -Systeme, Universität Bremen, 28359 Bremen, Germany.

This contribution outlines the design and manufacturing of a microfluidic device implemented as a biosensor for retrieval and detection of bacteria RNA. The device is fully made of Cyclo-Olefin Copolymer (COC), which features low auto-fluorescence, biocompatibility and manufacturability by hot-embossing. The RNA retrieval was carried on after bacteria heat-lysis by an on-chip micro-heater, whose function was characterized at different working parameters. Read More

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http://dx.doi.org/10.3390/s19051178DOI Listing
March 2019
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Erratum: Luan, E.X.; Shoman, H.; Ratner, D.M.; Cheung, K.C.; Chrostowski, L. Silicon Photonic Biosensors Using Label-Free Detection. 2018, , 3519.

Sensors (Basel) 2019 Mar 7;19(5). Epub 2019 Mar 7.

Department of Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4, Canada.

The authors wish to make the following corrections in their published paper in Sensors [... Read More

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http://dx.doi.org/10.3390/s19051161DOI Listing

Supramolecular steric hindrance effect on morphologies and photophysical behaviors of spirocyclic aromatic hydrocarbon nanocrystals.

Nanoscale 2019 Mar 13. Epub 2019 Mar 13.

Centre for Molecular Systems and Organic Devices (CMSOD), Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications (NUPT), 9 Wenyuan Road, Nanjing 210023, P.R. China. and Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an 710072, P.R. China.

Three pyrene-based spirocyclic aromatic hydrocarbons (Py-SAHs) were prepared to clarify the roles of molecular segments in regulating the morphologies and photophysical properties of organic microcrystals. Due to the different supramolecular steric hindrance (SSH) effect between bulky groups and pyrene rings, distinct nanocrystal morphologies with unique photoluminescence properties were realized. Read More

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http://dx.doi.org/10.1039/c9nr01064eDOI Listing

Genetically Encoded FRET-Based Tension Sensors.

Curr Protoc Cell Biol 2019 Mar 13:e85. Epub 2019 Mar 13.

Group of Molecular Mechanotransduction, Max Planck Institute of Biochemistry, Martinsried, Germany.

Genetically encoded Förster resonance energy transfer (FRET)-based tension sensors measure piconewton-scale forces across individual molecules in living cells or whole organisms. These biosensors show comparably high FRET efficiencies in the absence of tension, but FRET quickly decreases when forces are applied. In this article, we describe how such biosensors can be generated for a specific protein of interest, and we discuss controls to confirm that the observed differences in FRET efficiency reflect changes in molecular tension. Read More

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http://doi.wiley.com/10.1002/cpcb.85
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http://dx.doi.org/10.1002/cpcb.85DOI Listing
March 2019
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Tuning the response selectivity of graphene oxide fluorescence by organometallic complexation for neurotransmitter detection.

Nanoscale 2019 Mar 13. Epub 2019 Mar 13.

Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea.

It is of great interest to design nanomaterial biosensors that can selectively detect target molecules without the use of fragile and expensive antibodies. Here, we report a chemical approach to modulate the response selectivity of graphene oxide (GO) fluorescence for neurotransmitters, in order to design an optical biosensor for the selective detection of dopamine without using antibodies. To this end, GO was functionalized with six different amino acids, followed by the immobilization of seven metal ions, resulting in the production of forty-two different GO nanohybrids (denoted GO-AA-MI derivatives). Read More

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http://dx.doi.org/10.1039/c9nr00643eDOI Listing

Intelligent food packaging; a review of smart sensing technologies for monitoring food quality.

ACS Sens 2019 Mar 13. Epub 2019 Mar 13.

Food safety is a major factor affecting public health and the well-being of society. A possible solution to control food-borne illnesses is through real-time monitoring of the food quality throughout the food supply chain. The development of emerging technologies, such as active and intelligent packaging has been greatly accelerated in recent years, with a focus to inform consumers about food quality. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00440
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http://dx.doi.org/10.1021/acssensors.9b00440DOI Listing
March 2019
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When Biology Gets Personal: Hidden Challenges of Privacy and Ethics in Biological Big Data.

Pac Symp Biocomput 2019 ;24:386-390

Computational Biology and Bioinformatics Program, Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, 06511, USA*This work is partially supported by NIH grant U01EB023686.,

High-throughput technologies for biological data acquisition are advancing at an increasing pace. Most prominently, the decreasing cost of DNA sequencing has led to an exponential growth of sequence information, including individual human genomes. This session of the 2019 Pacific Symposium on Biocomputing presents the distinctive privacy and ethical challenges related to the generation, storage, processing, study, and sharing of individuals' biological data generated by multitude of technologies including but not limited to genomics, proteomics, metagenomics, bioimaging, biosensors, and personal health trackers. Read More

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January 2019
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Recent Developments in Printing Flexible and Wearable Sensing Electronics for Healthcare Applications.

Sensors (Basel) 2019 Mar 11;19(5). Epub 2019 Mar 11.

College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha 5825, Qatar.

Wearable biosensors attract significant interest for their capabilities in real-time monitoring of wearers' health status, as well as the surrounding environment. Sensor patches are embedded onto the human epidermis accompanied by data readout and signal conditioning circuits with wireless communication modules for transmitting data to the computing devices. Wearable sensors designed for recognition of various biomarkers in human epidermis fluids, such as glucose, lactate, pH, cholesterol, etc. Read More

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http://dx.doi.org/10.3390/s19051230DOI Listing

Conjugated Polymers for Assessing and Controlling Biological Functions.

Adv Mater 2019 Mar 12:e1806712. Epub 2019 Mar 12.

Department of Micro and Nanosystems, KTH Royal Institute of Technology, 10044, Stockholm, Sweden.

The field of organic bioelectronics is advancing rapidly in the development of materials and devices to precisely monitor and control biological signals. Electronics and biology can interact on multiple levels: organs, complex tissues, cells, cell membranes, proteins, and even small molecules. Compared to traditional electronic materials such as metals and inorganic semiconductors, conjugated polymers (CPs) have several key advantages for biological interactions: tunable physiochemical properties, adjustable form factors, and mixed conductivity (ionic and electronic). Read More

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http://dx.doi.org/10.1002/adma.201806712DOI Listing

Technological Interventions for Medication Adherence in Adult Mental Health and Substance Use Disorders: A Systematic Review.

JMIR Ment Health 2019 Mar 12;6(3):e12493. Epub 2019 Mar 12.

Outpatient Addiction Services, Department of Psychiatry, Cambridge Health Alliance, Somerville, MA, United States.

Background: Medication adherence is critical to the effectiveness of psychopharmacologic therapy. Psychiatric disorders present special adherence considerations, notably an altered capacity for decision making and the increased street value of controlled substances. A wide range of interventions designed to improve adherence in mental health and substance use disorders have been studied; recently, many have incorporated information technology (eg, mobile phone apps, electronic pill dispensers, and telehealth). Read More

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http://dx.doi.org/10.2196/12493DOI Listing

Real-Time Detection of Markers in Blood.

Nano Lett 2019 Mar 12. Epub 2019 Mar 12.

Department of Dermatology, Cutaneous Biology Research Institute , Yonsei University College of Medicine , Seoul , 03722 , Republic of Korea.

The real-time selective detection of disease-related markers in blood using biosensors has great potential for use in the early diagnosis of diseases and infections. However, this potential has not been realized thus far due to difficulties in interfacing the sensor with blood and achieving transparent circuits that are essential for detecting of target markers (e.g. Read More

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http://pubs.acs.org/doi/10.1021/acs.nanolett.8b04775
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http://dx.doi.org/10.1021/acs.nanolett.8b04775DOI Listing
March 2019
2 Reads

Wearable Electrochemical Alcohol Biosensors.

Curr Opin Electrochem 2018 Aug 23;10:126-135. Epub 2018 May 23.

Department of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA.

The rapid development of wearable sensing platforms in recent years has led to an array of viable monitoring applications for various target analytes. As a significant biomarker with high impact in diverse areas, the reliable on-body detection and continuous monitoring of alcohol has become a focus of many such systems. Currently, several commercial sensing platforms are available that are capable of transdermal monitoring of alcohol consumption using insensible sweat. Read More

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http://dx.doi.org/10.1016/j.coelec.2018.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407881PMC

The Sensor Proteins BcSho1 and BcSln1 Are Involved in, Though Not Essential to, Vegetative Differentiation, Pathogenicity and Osmotic Stress Tolerance in .

Front Microbiol 2019 25;10:328. Epub 2019 Feb 25.

Plant Protection Station of Pizhou City, Xuzhou, China.

High-osmolarity glycerol (HOG) signaling pathway belongs to mitogen-activated protein kinase (MAPK) cascades that regulate responses of organism to diverse extracellular stimuli. The membrane spanning proteins Sho1 and Sln1 serve as biosensors of HOG pathway in . In this study, we investigated the biological functions of and in the gray mold fungus . Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00328
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http://dx.doi.org/10.3389/fmicb.2019.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397835PMC
February 2019
1 Read

IN.PACT™ Admiral™ drug-coated balloons in peripheral artery disease: current perspectives.

Med Devices (Auckl) 2019 12;12:53-64. Epub 2019 Feb 12.

Cardiovascular Pathology, CVPath Institute, Inc., Gaithersburg, MD, USA,

Endovascular therapy has evolved as a main treatment option especially in patients with short (<25 cm) femoropopliteal lesion. The latest guideline recommends the use of drug-eluting devices (both drug-coated balloons [DCBs] and drug-eluting stents) in short femoro-popliteal lesions as class IIb recommendation. DCB usage is also recommended for in-stent restenosis lesions (class IIb). Read More

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http://dx.doi.org/10.2147/MDER.S165620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385763PMC
February 2019

Ultra-flat Gold QCM Electrodes Fabricated with Pressure Forming Template Stripping for Protein Studies at the Nanoscale.

Langmuir 2019 Mar 12. Epub 2019 Mar 12.

Single-molecule imaging of proteins using atomic force microscopy (AFM) is crucially dependent on protein attachment to ultra-flat substrates. The technique of template stripping (TS), which can be used to create large areas of atomically flat gold, has been used to great effect for this purpose. However, this approach requires an epoxy which can swell in solution, causing surface roughening and substantially increasing the thickness of any sample, preventing its use on acoustic resonators in liquid. Read More

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http://pubs.acs.org/doi/10.1021/acs.langmuir.8b03782
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http://dx.doi.org/10.1021/acs.langmuir.8b03782DOI Listing
March 2019
2 Reads

Sensitivity Enhancement of Two-Dimensional Materials Based on Genetic Optimization in Surface Plasmon Resonance.

Sensors (Basel) 2019 Mar 8;19(5). Epub 2019 Mar 8.

School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, China.

Sensitivity is an important performance index for evaluating surface plasmon resonance (SPR) biosensors. Sensitivity enhancement has always been a hot topic. It is found that the different refractive indices of samples require different combinations of prism and metal film for better sensitivity. Read More

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http://dx.doi.org/10.3390/s19051198DOI Listing

An Exfoliated Graphite-Based Electrochemical Immunosensor on a Dendrimer/Carbon Nanodot Platform for the Detection of Carcinoembryonic Antigen Cancer Biomarker.

Biosensors (Basel) 2019 Mar 8;9(1). Epub 2019 Mar 8.

Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa.

An electrochemical immunosensor for the quantification of carcinoembryonic antigen (CEA) using a nanocomposite of polypropylene imine dendrimer (PPI) and carbon nanodots (CNDTs) on an exfoliated graphite electrode (EG) is reported. The carbon nanodots were prepared by pyrolysis of oats. The nanocomposites (PPI and CNDTs) were characterized using X-ray powder diffraction (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), high-resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM). Read More

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http://dx.doi.org/10.3390/bios9010039DOI Listing

A chiral assembly of gold nanoparticle trimer-based biosensors for ultrasensitive detection of the major allergen tropomyosin in shellfish.

Biosens Bioelectron 2019 Feb 21;132:84-89. Epub 2019 Feb 21.

Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China. Electronic address:

A biosensor based on a chiral assembly of polymer of gold nanoparticle (AuNP) trimers was developed for the detection and quantification of the major shellfish allergen tropomyosin (TROP). TROP and anti-TROP monoclonal antibodies (mAb) were immobilized on 20 nm and 30 nm 16-mercaptohexadecanoic acid (16-MHDA) functionalized AuNPs to assemble a trimer, which has a Circular dichroism (CD) signal. The free TROP from samples was quantified as an inhibitor for the formation of the AuNP trimer. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.038DOI Listing
February 2019
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Oxygen-reducing microbial cathodes monitoring toxic shocks in tap water.

Biosens Bioelectron 2019 Feb 21;132:115-121. Epub 2019 Feb 21.

Center for Microbial Ecology and Technology (CMET), Campus Coupure - Ghent University, Coupure Links 653, 9000 Ghent, Belgium. Electronic address:

Electroactive biofilms (EABs) have recently attracted considerable research interest for their possible use as amperometric biosensors in environmental or bioprocess monitoring, for example for in situ detection of toxic compounds. Almost exclusively, corresponding research has focused on heterotrophic, anodic EABs. These biofilms require sufficiently high organic loads and anoxic conditions to deliver a stable baseline current. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.037DOI Listing
February 2019

Characteristics of BENZOPYRAN Laser Dyes in Annealed Silica XEROGEL.

J Fluoresc 2019 Mar 9. Epub 2019 Mar 9.

Institute for Single Crystals, NAS of Ukraine, 60 Nauky Ave, Kharkiv, 61001, Ukraine.

The spectroscopic and laser characteristics of two benzopyrane derivatives for 600-670 nm spectrum region of lasing in preliminarily annealed silica xerogel matrices in non-selective cavity under laser pumping at 551 nm have been measured and analysed. The influence of molecular structure of the dyes on their non-radiating losses has been revealed. The specific output laser energy of the studied matrices was approximately equal to the ones for corresponding methanol solutions under the same pumping conditions. Read More

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http://link.springer.com/10.1007/s10895-019-02357-5
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http://dx.doi.org/10.1007/s10895-019-02357-5DOI Listing
March 2019
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Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1.

BMJ Case Rep 2019 Mar 8;12(3). Epub 2019 Mar 8.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

A man in his early 60s with myotonic dystrophy type 1 (DM1) and an extensive history of non-melanoma skin cancer presented with multiple pearly, erythematous papules on his face, head, trunk and extremities, clinically consistent with basal cell carcinoma (BCC). Due to the numerous BCC and history of multiple and early-onset BCC, examination was concerning for a hereditary BCC syndrome. Subsequent histopathology confirmed BCC. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22723
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http://dx.doi.org/10.1136/bcr-2018-227233DOI Listing
March 2019
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Point-of-care testing based on smartphone: The current state-of-the-art (2017-2018).

Biosens Bioelectron 2019 Feb 19;132:17-37. Epub 2019 Feb 19.

State Key Laboratory of Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

Smartphone-based point-of-care testing (POCT) is rapidly emerging as a potential alternative to the traditional laboratory-based diagnostic testing owing to economic considerations and availability of medical equipment especially in resource-limited areas. A smartphone, combined with a biosensor and other related accessories, can offer high accuracy and sensitivity for medical testing. Moreover, the ubiquity of smartphone has propelled the development considerably, and accordingly research in recent years has shown promising progress in POCT. Read More

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http://dx.doi.org/10.1016/j.bios.2019.01.068DOI Listing
February 2019
3 Reads
6.409 Impact Factor

Electrochemical cardiovascular platforms: Current state of the art and beyond.

Biosens Bioelectron 2019 Feb 19;131:287-298. Epub 2019 Feb 19.

Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520-IEMN, F-59000 Lille, France. Electronic address:

Cardiovascular diseases (CVD) remain the leading cause of death within industrialized nations as well as an increasing cause of mortality and morbidity in many developing countries. Smoking, alcohol consumption and increased level of blood cholesterol are the main CVD risk factors. Other factors, such as the prevalence of overweight/obesity and diabetes, have increased considerably in recent decades and are indirect causes of CVD. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.010DOI Listing
February 2019
2 Reads

Automated FRET quantification reveals distinct subcellular ERK activation kinetics in response to graded EGFR signaling in Drosophila.

Genes Cells 2019 Mar 9. Epub 2019 Mar 9.

Laboratory for Morphogenetic Signaling, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Threshold responses to an activity gradient allow a single signaling pathway to yield multiple outcomes. Extracellular signal-regulated kinase (ERK) is one such signal, which couples receptor tyrosine kinase signaling with multiple cellular responses in various developmental processes. Recent advances in the development of fluorescent biosensors for live imaging have enabled the signaling activities accompanying embryonic development to be monitored in real time. Read More

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http://doi.wiley.com/10.1111/gtc.12679
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http://dx.doi.org/10.1111/gtc.12679DOI Listing
March 2019
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Facile fabrication of flexible glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink.

Biosens Bioelectron 2019 Jan 31;131:257-266. Epub 2019 Jan 31.

Weldon School of Biomedical Engineering, Birck Nanotechnology Center, Center for Implantable Device, Purdue University, West Lafayette, IN, USA. Electronic address:

Glutamate excitotoxicity is a pathology in which excessive glutamate can cause neuronal damage and degeneration. It has also been linked to secondary injury mechanisms in traumatic spinal cord injury. Conventional bioanalytical techniques used to characterize glutamate levels in vivo, such as microdialysis, have low spatiotemporal resolution, which has impeded our understanding of this dynamic event. Read More

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http://dx.doi.org/10.1016/j.bios.2019.01.051DOI Listing
January 2019
1 Read