11,220 results match your criteria Biosens Bioelectron[Journal]


Highly stable Ru-complex-grafted 2D metal-organic layer with superior electrochemiluminescent efficiency as a sensing platform for simple and ultrasensitive detection of mucin 1.

Biosens Bioelectron 2019 Mar 15;135:95-101. Epub 2019 Mar 15.

Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address:

This work utilized ultrathin metal-organic layer (MOL) to immobilize luminophores for effectively shortening the ion/electron-transport distance and relieving the diffusional constraints of ion/electron, which greatly enhanced the ECL efficiency and intensity. Moreover, the MOL's immobilization amount of luminophores should be higher than these of bulk MOFs because MOLs possess more accessible postmodification sites for the luminophores with minimal diffusion barriers. As expected, our proof-of-concept experiment indicated that the Hf-MOL's loading number of Ru(bpy)(mcpbpy) was about 1. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.026DOI Listing

Fabrication of hierarchical MIL-68(In)-NH/MWCNT/CdS composites for constructing label-free photoelectrochemical tetracycline aptasensor platform.

Biosens Bioelectron 2019 Apr 4;135:88-94. Epub 2019 Apr 4.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.

It is essential to develop a highly efficient detection platform for tetracycline (Tc). Herein, based on well-designed hierarchical MIL-68(In)-NH/MWCNT/CdS composites as a highly efficient transducer, a label-free visible light driven photoelectrochemical (PEC) aptasensor was systematically fabricated. Characterization results indicate that the forming of MIL-68(In)-NH/CdS heterojunction remarkable facilitated the transfer and inhibited the recombination of charge carriers. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.062DOI Listing

Permselective glucose sensing with GLUT1-rich cancer cell membranes.

Biosens Bioelectron 2019 Apr 12;135:82-87. Epub 2019 Apr 12.

School of Biomedical Engineering, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Enzymatic blood glucose detection with selectivity is one of the most important conundrums, because human blood contains many components that can hinder enzyme-substrate reactions. Meanwhile, cancer cells express much higher levels of glucose transporter-1 on their cell membrane to selectively and excessively uptake more α-D-glucose than do normal cells. Inspired by such cellular permselectivity for glucose, herein we significantly improved the selectivity of a glucose sensor by using a breast cancer cell membrane (BCCM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193028
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http://dx.doi.org/10.1016/j.bios.2019.04.007DOI Listing
April 2019
1 Read
6.409 Impact Factor

Direct quantification of cancerous exosomes via surface plasmon resonance with dual gold nanoparticle-assisted signal amplification.

Biosens Bioelectron 2019 Apr 13;135:129-136. Epub 2019 Apr 13.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, China. Electronic address:

Sensitive detection of cancerous exosomes is critical to early diseases diagnosis and prognosis. Herein, a sensitive aptasensor was demonstrated for exosomes detection by surface plasmon resonance (SPR) with dual gold nanoparticle (AuNP)-assisted signal amplification. Dual nanoparticle amplification was achieved by controlled hybridization attachment of AuNPs resulting from electronic coupling between the Au film and AuNPs, as well as coupling effects in plasmonic nanostructures. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.013DOI Listing

Fully integrated and slidable paper-embedded plastic microdevice for point-of-care testing of multiple foodborne pathogens.

Biosens Bioelectron 2019 Apr 11;135:120-128. Epub 2019 Apr 11.

Department of BioNano Technology, Gachon University 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, South Korea. Electronic address:

This study presents a slidable paper-embedded plastic microdevice fully integrated with DNA extraction, loop-mediated isothermal amplification (LAMP), and colorimetric detection functionalities. The developed microdevice consists of three layers that allow a sliding movement to mix the sample and reagents for DNA purification, amplification, and detection in a sequential manner. An FTA card was employed in the main chamber for DNA extraction and purification from intact bacterial cells. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.011DOI Listing

On-line regeneration of electrochemical biosensor for in vivo repetitive measurements of striatum Cu under global cerebral ischemia/reperfusion events.

Biosens Bioelectron 2019 Mar 9;135:111-119. Epub 2019 Mar 9.

School of Chemistry and Chemical Engineering, Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan 411201, PR China. Electronic address:

The detection of Cu ion, one of the metal ions substantial in cerebral physiology, is critical in studying brain activities and understanding brain functions. However, repetitive measurements of Cu in the progress of physiological and pathological events is still challenging, because lack of the platform for repetitive on-line detection-regeneration cycle. Herein we report the design of a regenerated electrochemical biosensor combined with the in vivo microdialysis system. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.014DOI Listing

An ultra-sensitive aptasensor on optical fibre for the direct detection of bisphenol A.

Biosens Bioelectron 2019 Feb 22;135:102-110. Epub 2019 Feb 22.

Dipartimento di Chimica "Ugo Schiff" and CSGI, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.

We present a plasmonic biosensor capable of detecting the presence of bisphenol A in ultra-low concentrations, yielding a wavelength shift of 0.15 ± 0.01 nm in response to a solution of 1 fM concentration with limit of detection of 330 ± 70 aM The biosensing device consists of an array of gold nano-antennae with a total length of 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193016
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http://dx.doi.org/10.1016/j.bios.2019.02.043DOI Listing
February 2019
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Early stage detection and screening of ovarian cancer: A research opportunity and significant challenge for biosensor technology.

Biosens Bioelectron 2019 Mar 20;135:71-81. Epub 2019 Mar 20.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6. Electronic address:

Women diagnosed with late-stage ovarian cancer suffer a very high rate of mortality. Accordingly, it is imperative to detect and diagnose the disease as early as possible in its development. Achievement of this aim implies relatively large scale screening of women at an age of clinically significance through assay of biomarkers for disease present in blood or serum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193024
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http://dx.doi.org/10.1016/j.bios.2019.03.041DOI Listing
March 2019
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Sampling and multiplexing in lab-on-paper bioelectroanalytical devices for glucose determination.

Biosens Bioelectron 2019 Apr 5;135:64-70. Epub 2019 Apr 5.

Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo, 33006, Oviedo, Spain. Electronic address:

In this work, we present a multiplexed (eight simultaneous measurements) paper-based electrochemical device developed in a very simple way and using low-cost materials, such as paper, carbon ink and multifunctional connector headers. Meanwhile, we have also combined the paper-based electrochemical platform with a glass-fiber strip in order to integrate easily a sampling step. Both approaches, simultaneous measuring and sampling, have been applied to the determination of glucose using bienzymatic biosensors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193028
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http://dx.doi.org/10.1016/j.bios.2019.04.006DOI Listing
April 2019
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Application of conducting polymers to wound care and skin tissue engineering: A review.

Biosens Bioelectron 2019 Apr 6;135:50-63. Epub 2019 Apr 6.

Nanyang Environment and Water Research Institute, Residues and Resource Reclamation Center, 1 Cleantech Loop, CleanTech, Singapore, 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore. Electronic address:

The use of intrinsically conducting polymers (CPs) in wound care and skin tissue engineering presents a novel opportunity for accelerated wound healing, enhanced antibacterial activity and the potential for controlled drug delivery. Through their increased electrical conductivity, CPs can facilitate the application of electrical stimulation directly to the wound area, which has been linked to faster wound healing. The release of drugs or biological agents to the wound site can likewise be modulated through the use of an external electrical stimuli. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193028
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http://dx.doi.org/10.1016/j.bios.2019.04.001DOI Listing
April 2019
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Enzyme-free glucose sensor based on layer-by-layer electrodeposition of multilayer films of multi-walled carbon nanotubes and Cu-based metal framework modified glassy carbon electrode.

Biosens Bioelectron 2019 Apr 9;135:45-49. Epub 2019 Apr 9.

College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, PR China. Electronic address:

A high-performance nonenzymatic glucose sensor was successfully prepared by a layer by layer strategy through electrodeposition assembling multilayer films of Cu-metal-organic frameworks/multi-walled carbon nanotubes (Cu-MOF/MWNTs) modified glassy carbon electrodes (GCE). Different multilayer films of Cu-MOF/MWNTs modified GCE (Cu-MOF/MWNTs/GCE) were prepared by repeating the electrodeposition of MWNTs onto the GCE in an MWNTs solution (MWNTs/GCE) and electrodeposition of the Cu-MOF layer onto the MWNTs film surface to form a Cu-MOF/MWNTs composite layer in the crystallization solution of Cu-MOF. Results confirmed that this method to fabricate multilayer composite films on the GCE was fast and convenient, and that multilayer composite films were stable and unified. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.064DOI Listing
April 2019
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Electrochemical simultaneous analysis of dopamine and epinephrine using double imprinted One MoNomer acryloylated graphene oxide-carbon black composite polymer.

Biosens Bioelectron 2019 Apr 11;135:36-44. Epub 2019 Apr 11.

Analytical Division, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

A novel One MoNomer dual imprinted graphene oxide/carbon black composite polymer was developed applying 'surface-grafting from' approach on the screen printed carbon electrode for the electrochemical sensing of dopamine and epinephrine. Acryloylated-graphene oxide/carbon black was synthesized for the first time. This served both as a crosslinker and monomer leading to the fast electron transfer from the redox centre to the electrode. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.016DOI Listing

Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor.

Biosens Bioelectron 2019 Apr 11;135:30-35. Epub 2019 Apr 11.

Department of Genetics, Faculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tzankov Blvd., 1164, Sofia, Bulgaria. Electronic address:

An automated DNA hybridization transfer in a microflow reactor is demonstrated by moving paramagnetic beads between two spatially separate solutions with different pH values. The microbeads-based microfluidic platform is fully automated and programmable. It employs a robust chemical procedure for specific DNA hybridization transfer in microfluidic devices under isothermal conditions based on reversible pH alterations. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.014DOI Listing

Bimetallic cerium and ferric oxides nanoparticles embedded within mesoporous carbon matrix: Electrochemical immunosensor for sensitive detection of carbohydrate antigen 19-9.

Biosens Bioelectron 2019 Apr 11;135:22-29. Epub 2019 Apr 11.

Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, 450001, PR China. Electronic address:

A label-free electrochemical immunosensor was successfully developed for sensitively detecting carbohydrate antigen 19-9 (CA19-9) as a cancer marker. To achieve this, a series of bimetallic cerium and ferric oxide nanoparticles embedded within the mesoporous carbon matrix (represented by CeO/FeO@mC) was obtained from the bimetallic CeFe-based metal organic framework (CeFe-MOF) by calcination at different high temperatures. The formed CeO or FeO nanoparticles were uniformly distributed within the highly graphitized mesoporous carbon matrix at the calcination temperature of 500 °C (represented by CeO/FeO@mC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193029
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http://dx.doi.org/10.1016/j.bios.2019.04.018DOI Listing
April 2019
2 Reads

Specific detection of avian influenza H5N2 whole virus particles on lateral flow strips using a pair of sandwich-type aptamers.

Biosens Bioelectron 2019 Jun 1;134:123-129. Epub 2019 Apr 1.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Anam-dong, Seongbuk-gu, Seoul, 136-701, Republic of Korea. Electronic address:

We report a selection of a cognate pair of aptamers for whole avian influenza virus particles of H5N2 by using graphene-oxide based systemic evolution of ligands by exponential enrichment (GO-SELEX), and the application of a pair of sandwich-type binding aptamers on the lateral flow strips. The aptamers were characterized by GO-FRET assay, and Kd values of the selected aptamers were estimated to be from 6.913 × 10 to 1. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.061DOI Listing
June 2019
2 Reads

Phosphorene-gold nanocomposite based microfluidic aptasensor for the detection of okadaic acid.

Biosens Bioelectron 2019 Apr 5;135:14-21. Epub 2019 Apr 5.

School of Engineering, University of Guelph, Guelph, ON, N1G 2W1, Canada. Electronic address:

Okadaic acid (OA) is one of the most prevalent and largely distributed bio-toxin in the world. Consumption of OA results in a series of digestive ailments such as nausea and diarrhea. This study demonstrates the preparation and functioning of an electrochemical microfluidic biochip for the detection of OA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193027
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http://dx.doi.org/10.1016/j.bios.2019.03.056DOI Listing
April 2019
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3D hierarchical hollow hydrangea-like Fe@ɛ-MnO microspheres with excellent electrochemical performance for dopamine and hydrogen peroxide.

Biosens Bioelectron 2019 May 11;133:250-257. Epub 2019 Mar 11.

Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China. Electronic address:

Construction a sensor to accurately detect dopamine (DA) and hydrogen peroxide (HO) is meaningful due to their close relation to the health of organisms. In this work, one-step hydrothermal method was employed to synthesize hierarchical hollow hydrangea-like Fe@ɛ-MnO microspheres constructed by interconnected nanosheets, and the growth mechanism of the microspheres (n/n = 0.6) was also investigated in detail. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.017DOI Listing

Two-layer three-dimensional DNA walker with highly integrated entropy-driven and enzyme-powered reactions for HIV detection.

Biosens Bioelectron 2019 May 13;133:243-249. Epub 2019 Mar 13.

Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Here, we propose a new two-layer three-dimensional (3-D) DNA walker sensor with highly integrated entropy-driven and enzyme-powered reactions for the first time. The 3-D DNA walker sensor is constructed by assembling densely carboxyfluorescein-labeled single strand oligonucleotides (inner-layer tracks) and nucleic acid complex S (outer-layer tracks) on a microparticle. In the presence of the target, outer and inner tracks are activated in turn, thereby releasing a great deal of the signal reporters for signal reading. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.015DOI Listing

A dual-response biosensor for electrochemical and glucometer detection of DNA methyltransferase activity based on functionalized metal-organic framework amplification.

Biosens Bioelectron 2019 Jun 29;134:117-122. Epub 2019 Mar 29.

College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, PR China; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210023, PR China. Electronic address:

DNA methylation is catalyzed by DNA methyltransferase (MTase) and concerned with many biological processes including pathogenesis of various human diseases. The monitoring of MTase activity is thus of great significance in disease diagnosis and drug screening. Herein, we developed a facile way to synthesize biocompatible invertase enzyme modified metal-organic framework (Invertase/MOF) materials, and explored its application in constructing a dual-response Dam MTase sensor for the first time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193026
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http://dx.doi.org/10.1016/j.bios.2019.03.051DOI Listing
June 2019
2 Reads

An ultrasensitive electrochemiluminescence biosensor for MicroRNA detection based on luminol-functionalized Au NPs@ZnO nanomaterials as signal probe and dissolved O as coreactant.

Biosens Bioelectron 2019 Apr 6;135:8-13. Epub 2019 Apr 6.

Key Laboratory of Ministry of Education of Luminescence and Real-Time Analytical Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:

In this work, the ZnO nanostars with excellent catalytic performance were firstly used as the coreaction accelerator of luminol-O system to construct a biosensor for ultrasensitively detecting microRNA-21 (miRNA-21) in cancer cells. Specifically, ZnO nanostars could expedite the reduction of dissolved O, generating more reactive oxygen species (ROSs) to extremely promote electrochemiluminescence (ECL) luminous efficiency of luminol. Thus luminol-functionalized Au NPs@ZnO (L-Au NPs@ZnO) nanomaterials were employed as signal probe to fabricate sensing nano-platform for achieving significant ECL emission as "signal on" state. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.004DOI Listing

A paper-based electrochemical immunosensor with reduced graphene oxide/thionine/gold nanoparticles nanocomposites modification for the detection of cancer antigen 125.

Biosens Bioelectron 2019 Apr 5;135:1-7. Epub 2019 Apr 5.

Intelligence and Information Engineering College of Tangshan University, Tangshan, 063000, China.

A paper-based electrochemical immunosensor was developed for the detection of cancer antigen 125 (CA125) by screen-printing technique. The reduced graphene oxide/thionine/gold nanoparticles (rGO/Thi/AuNPs) nanocomposites were compounded and coated onto the working electrode of immunosensor for CA125 antibody (anti-CA125) immobilization and detection signal amplification. The detection principle was based on the fact that the immunocomplex formed by specify binding of CA125 antibody and antigen could reduce the current response of thionine, which was proportional to the corresponding concentration of CA125 antigen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193027
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http://dx.doi.org/10.1016/j.bios.2019.03.063DOI Listing
April 2019
2 Reads

Dual-signal-amplified electrochemiluminescence biosensor for microRNA detection by coupling cyclic enzyme with CdTe QDs aggregate as luminophor.

Biosens Bioelectron 2019 Jun 3;134:109-116. Epub 2019 Apr 3.

Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. Electronic address:

In this work, a dual-signal-amplified electrochemiluminescence (ECL) biosensor was proposed for the first time to detect microRNAs (miRNAs) based on cyclic enzyme and seeded-watermelon-like mesoporous nanospheres (mSiO@CdTe@SiO, mSQS NSs). mSQS NSs were successfully fabricated by inlaying the CdTe quantum dots (QDs) into the mesoporous silica (mSiO) and future coating the surface with the silica layer. The obtained mSQS NSs contained tens of QDs and exhibited much stronger ECL signal than single QDs. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.005DOI Listing
June 2019
1 Read

A 96-well wax printed Prussian Blue paper for the visual determination of cholinesterase activity in human serum.

Biosens Bioelectron 2019 Jun 19;134:97-102. Epub 2019 Mar 19.

Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy. Electronic address:

In the last decades, there is a growing search for analytical strategies to ensure clinical analysis without the need of laboratory set-up and skilled personnel. Indeed, user-friendly and low-cost devices are highly valued in the era of sustainability for their capability to be applied in low-resource contexts, such as developing countries. To address this issue, herein we report a 96-well paper-based and laboratory setup-free optical platform for the detection of butyrylcholinesterase enzyme (BChE) activity in human serum. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.037DOI Listing

LSPR based optical fiber sensor with chitosan capped gold nanoparticles on BSA for trace detection of Hg (II) in water, soil and food samples.

Biosens Bioelectron 2019 Jun 22;134:90-96. Epub 2019 Mar 22.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India. Electronic address:

Mercury is a diversely bioaccumulating heavy metal pollutant toxic to all life forms. In this work, an optical biosensor has been developed and calibrated for universal detection and quantification of mercuric ions, in the range 0.1-540 parts per billion, in biological and environmental samples. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.046DOI Listing
June 2019
3 Reads

An extended core nanocoax pillar architecture for enhanced molecular detection.

Biosens Bioelectron 2019 Jun 22;134:83-89. Epub 2019 Mar 22.

Department of Physics, Boston College, Chestnut Hill, MA 02467, United States. Electronic address:

Biosensors that incorporate nanomaterials and nanofabrication techniques enable molecular detection of chemical and biological macromolecules with a high degree of specificity and ultrasensitivity. Here, we present a novel fabrication process that yields a nanostructure capable of detecting biological macromolecules. The extended core nanocoax (ECC) structure builds on a previously reported nanocoaxial-based sensor. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.045DOI Listing
June 2019
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Binding-induced formation of DNAzyme on an Au@Ag nanoparticles/TiO nanorods electrode: Stimulating biocatalytic precipitation amplification for plasmonic photoelectrochemical bioanalysis.

Biosens Bioelectron 2019 Jun 30;134:103-108. Epub 2019 Mar 30.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. Electronic address:

Photoelectrochemical (PEC) DNA bioanalysis has been drawing more attention in recent years due to the advantages of PEC technique and the vital importance of DNA biomolecules. DNAzymes are unique catalytic nucleic acid molecules that are capable of catalyzing specific biochemical reactions. Using the target-binding-induced conformation change of hairpin DNA probe to hemin/G-quadruplex-based DNAzyme and a plasmonic Au@Ag nanoparticles (NPs)/TiO nanorods (NRs)/fluorine-doped tin oxide (FTO) heterostructured photoelectrode, this work reported a novel and sensitive PEC DNA analysis on the basis of a DNAzyme-stimulated biocatalytic precipitation (BCP) strategy. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.059DOI Listing
June 2019
1 Read
6.409 Impact Factor

Electrochemical genosensor for the direct detection of tailed PCR amplicons incorporating ferrocene labelled dATP.

Biosens Bioelectron 2019 Jun 30;134:76-82. Epub 2019 Mar 30.

Departament d'Enginyeria Química, Universitat Rovira i Virgili, 26 Països Catalans, 43007, Tarragona, Spain; Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís Companys, 23, 08010, Barcelona, Spain. Electronic address:

An electrochemical genosensor for the detection and quantification of Karlodinium armiger is presented. The genosensor exploits tailed primers and ferrocene labelled dATP analogue to produce PCR products that can be directly hybridised on a gold electrode array and quantitatively measured using square wave voltammetry. Tailed primers consist of a sequence specific for the target, followed by a carbon spacer and a sequence specifically designed not to bind to genomic DNA, resulting in a duplex flanked by single stranded binding primers. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.060DOI Listing
June 2019
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6.409 Impact Factor

A portable nucleic acid detection system using natural convection combined with a smartphone.

Biosens Bioelectron 2019 Jun 29;134:68-75. Epub 2019 Mar 29.

Department of Molecular Sciences, Macquarie University, Sydney, Australia; Biomolecular Discovery and Design Research Centre, Macquarie University, Sydney, Australia. Electronic address:

The development of portable nucleic acid diagnostic devices has the potential to expand the availability of molecular diagnostics into low-resource settings. One of the promising solutions for rapid and simple DNA amplification is the use of Rayleigh-Bernard natural convection which is caused by a buoyancy-driven thermal gradient of liquid when heated from below. This natural convection avoids the use of the complex and sophisticated hardware that is required for precise maintenance of temperature cycles in conventional PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193026
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http://dx.doi.org/10.1016/j.bios.2019.03.050DOI Listing
June 2019
3 Reads

A review of microfabricated electrochemical biosensors for DNA detection.

Biosens Bioelectron 2019 Jun 29;134:57-67. Epub 2019 Mar 29.

Department of Biomedical Engineering, University of Strathclyde, Glasgow, G4 0NS, UK.

This review article presents an overview of recent work on electrochemical biosensors developed using microfabrication processes, particularly sensors used to achieve sensitive and specific detection of DNA sequences. Such devices are important as they lend themselves to miniaturisation, reproducible mass-manufacture, and integration with other previously existing technologies and production methods. The review describes the current state of these biosensors, novel methods used to produce them or enhance their sensing properties, and pathways to deployment of a complete point-of-care biosensing system in a clinical setting. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.055DOI Listing
June 2019
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Electrochemical dual-aptamer-based biosensor for nonenzymatic detection of cardiac troponin I by nanohybrid electrocatalysts labeling combined with DNA nanotetrahedron structure.

Biosens Bioelectron 2019 Jun 29;134:49-56. Epub 2019 Mar 29.

Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, 510006, China; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou, 510006, China; Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, 510006, China. Electronic address:

The accurate detection of biomarkers for acute myocardial infarction (AMI) plays an important role in clinical diagnosis and management process. In this work, we developed an electrochemical biosensor by using magnetic metal organic framework (MMOF) nanocatalysts and DNA nanotetrahedron (NTH) based dual-aptamer probes for nonenzymatic detection of cardiac troponin I (cTnI), a gold standard biomarker for the early diagnosis of AMI. Firstly, the NTH-assisted dual-aptamer (Tro4 and Tro6) capture probes were immobilized on the screen-printed gold electrode (SPGE) for the highly enhanced capture the target cTnI with steady support and optimized interface density. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.049DOI Listing
June 2019
2 Reads

Simple "signal-on" photoelectrochemical aptasensor for ultrasensitive detecting AFB1 based on electrochemically reduced graphene oxide/poly(5-formylindole)/Au nanocomposites.

Biosens Bioelectron 2019 Jun 28;134:42-48. Epub 2019 Mar 28.

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, PR China. Electronic address:

A simple "signal-on" photoelectrochemical (PEC) aptasensor is constructed for Aflatoxin B1 (AFB1) detection based on electrochemically reduced graphene oxide/poly(5-formylindole)/Au (erGO/P5FIn/Au) nanocomposites. The nanocomposites are synthesized by simple electrochemical deposition method and show good photoelectrochemical performance. Poly(5-formylindole) (P5FIn) can generate electron-hole pairs under light irradiation, leading to the formation of robust cathode photocurrent. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.048DOI Listing

Novel strategy to improve the sensing performances of split ATP aptamer based fluorescent indicator displacement assay through enhanced molecular recognition.

Biosens Bioelectron 2019 Jun 27;134:36-41. Epub 2019 Mar 27.

College of Chemistry and Molecular Engeering, Zhengzhou University, Zhengzhou, 450001, China.

Split aptamer strategy was often used to improve the sensitivity of aptasensor. However, traditional split aptamer strategy can not be directly used to improve the label-free aptamer based Thioflavin T (ThT) displacement assay for ATP because the split ATP aptamer display much lower enhancement effects on the fluorescence of ThT than intact aptamer. In order to address this issue, this is the first report using G-rich DNA sequence to enhance the affinity of the two split ATP aptamer halves to ThT and offer lower limit of detection (LOD), wider linear range and higher selectivity through the enhanced molecular recognition. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.047DOI Listing

Silver-based metal-organic gels as novel coreactant for enhancing electrochemiluminescence and its biosensing potential.

Biosens Bioelectron 2019 Jun 29;134:29-35. Epub 2019 Mar 29.

Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. Electronic address:

Metal-organic gels (MOGs), a kind of soft materials, were reported as a brand new category of novel solid coreactants for enhancing electrochemiluminescence (ECL) of Ru (bpy) and derivatives. In this work, silver-based MOGs (Ag-MOGs) prepared by a one-step mixing and heating approach were demonstrated as novel efficient solid-state coreactants which differ from the previous research on ECL coreactant nanomaterials. It was discussed that the possible enhancement mechanism was due to the amino-rich groups and the electro-catalytic effect of Ag-MOGs, endowing them promising coreactants for the enhancement of Ru (bpy) ECL. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.058DOI Listing
June 2019
6.409 Impact Factor

Target trapping and in situ single-cell genetic marker detection with a focused optical beam.

Biosens Bioelectron 2019 May 28;133:236-242. Epub 2019 Feb 28.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Optical trapping of single particles or cells with the capability of in situ bio-sensing or genetic profiling opens the possibility of rapid screening of biological specimens. However, common optical tweezers suffer from the lack of long-range forces. Consequently, their application areas are predominantly limited to target manipulation instead of biological diagnostics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193010
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http://dx.doi.org/10.1016/j.bios.2019.02.009DOI Listing
May 2019
7 Reads

Glucose oxidase mimicking half-sandwich nickel(II) complexes of coumarin substituted N-heterocyclic carbenes as novel molecular electrocatalysts for ultrasensitive and selective determination of glucose.

Biosens Bioelectron 2019 Jun 29;134:24-28. Epub 2019 Mar 29.

Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Kanakapura, Ramanagaram, Bangalore, 562112, India.

Glucose oxidase mimicking nickel-based porous structures with organic anchors are developed as cheap and reliable electrochemical sensors for the quantitative detection of glucose. A series of sterically and electronically modulated, air- and moisture-stable half-sandwich nickel(II) NHC complexes were prepared and characterized. Under the optimized electrocatalytic conditions, the nickel complex immobilized glassy carbon electrodes (GCEs) displayed high sensitivity (0. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.057DOI Listing
June 2019
1 Read

Bimetallic ZrHf-based metal-organic framework embedded with carbon dots: Ultra-sensitive platform for early diagnosis of HER2 and HER2-overexpressed living cancer cells.

Biosens Bioelectron 2019 Jun 22;134:8-15. Epub 2019 Mar 22.

Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, Zhengzhou 450002, PR China. Electronic address:

We report here a new bimetallic ZrHf metal-organic framework (ZrHf-MOF) embedded with abundant carbon dots (CDs) (denoted as CDs@ZrHf-MOF), which exhibits strong fluorescence and rich-amino-functionalization. The CDs@ZrHf-MOF can be applied as the scaffold for anchoring aptamer strands to determine human epidermal growth factor receptor-2 (HER2) and living HER2-overexpressed MCF-7 cells. The basic characterizations reveal that the CDs are embedded within the interior cavities of ZrHf-MOF without varying the nanostructure, leading to good biocompatibility, strong fluorescence, and high electrochemical activity of CDs@ZrHf-MOF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193024
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http://dx.doi.org/10.1016/j.bios.2019.03.043DOI Listing
June 2019
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Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva.

Biosens Bioelectron 2019 Jun 29;134:16-23. Epub 2019 Mar 29.

Key Laboratory of Micro-systems and Micro-structures Manufacturing, Ministry of Education and School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150010, China.

Saliva has been reported to contain various cytokine biomarkers which are associated with some severe diseases such as cancers. Non-invasive saliva diagnosis using wearable or portable devices may pave a new avenue for monitoring conditions of the high risk population. Here, a graphene-based fully integrated portable nanosensing system, the entire size of which is smaller than a smart-phone and can be handheld, is presented for on-line detection of cytokine biomarkers in saliva. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.053DOI Listing
June 2019
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An electrochemical sensing platform based on ladder-shaped DNA structure and label-free aptamer for ultrasensitive detection of ampicillin.

Biosens Bioelectron 2019 May 22;133:230-235. Epub 2019 Mar 22.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Herein, an electrochemical aptasensor is described for detection of ampicillin (Ampi). The sensing strategy is based on the application of a ladder-shaped DNA structure as a multi-layer physical block on the surface of gold electrode. Attributing to the electrostatic repulsion and physical prevention of the ladder-shaped DNA structure, ultrasensitive detection of Ampi was achieved with a detection limit as low as 1 pM. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.044DOI Listing

A high-sensitivity thermal analysis immunochromatographic sensor based on au nanoparticle-enhanced two-dimensional black phosphorus photothermal-sensing materials.

Biosens Bioelectron 2019 May 20;133:223-229. Epub 2019 Mar 20.

State Key Laboratory for Food Nutrition and Safety; College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, PR China. Electronic address:

For the first time, a quantitative photothermal-sensing immunochromatographic sensor (PT-ICS) is described using Au nanoparticle-enhanced two-dimensional black phosphorus (BP-Au) as signal component for the photothermal-sensing antibody probe. BP-Au has good photothermal properties at 808 nm, and the photothermal conversion efficiency of the BP-Au nanosheet increased by 12.9% over the black phosphorus nanosheet alone. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.039DOI Listing
May 2019
2 Reads

Ultra-sensitive electrochemical detection of bacteremia enabled by redox-active gold nanoparticles (raGNPs) in a nano-sieving microfluidic system (NS-MFS).

Biosens Bioelectron 2019 May 20;133:215-222. Epub 2019 Mar 20.

Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan ROC; Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan ROC; Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan, ROC. Electronic address:

Early diagnosis of bacterial infections is crucial to improving survival rates by enabling treatment with appropriate antibiotics within the first few hours of infection. This paper presents a highly sensitive amperometric biosensor for the detection of several pathogenic bacterial cells in blood plasma around 30 min. The proposed device is based on an electropolymerized self-assembled layer on gold nanoparticles operated in a portable nano-sieving microfluidic system (NS-MFS). Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.040DOI Listing
May 2019
2 Reads

All-solid-state metal-mediated Z-scheme photoelectrochemical immunoassay with enhanced photoexcited charge-separation for monitoring of prostate-specific antigen.

Biosens Bioelectron 2019 Jun 29;134:1-7. Epub 2019 Mar 29.

Key Laboratory for Analytical Science of Food Safety and Biology (MOE & Fujian Province), State Key Laboratory of Photocatalysis on Energy and Environment, Department of Chemistry, Fuzhou University, Fuzhou, 350116, PR China. Electronic address:

An all-solid-state metal-mediated Z-scheme photoelectrochemical (PEC) immunoassay was designed for sensitive detection of prostate-specific antigen (PSA) by using WO-Au-CdS nanocomposite as photoactive material and copper ion (Cu) as an inhibitor. The Z-scheme PEC system comprising of CdS nanoparticle (photosystem I; PS I), WO nanorod (photosystem II; PS II) and gold nanoparticle (Au NP; solid electron mediator) was reasonably established by a simple and green synthetic method. As an important part of Z-scheme system, the sandwiched gold nanoparticles between electron donor materials and hole provider materials could accelerate electron transfer from positive conduction band (CB) of WO to negative valence band (VB) of CdS, thus resulting in high-efficient separation of the carriers. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.052DOI Listing

Ultra-selective fiber optic SPR platform for the sensing of dopamine in synthetic cerebrospinal fluid incorporating permselective nafion membrane and surface imprinted MWCNTs-PPy matrix.

Biosens Bioelectron 2019 May 13;133:205-214. Epub 2019 Mar 13.

Department of Physics, Indian Institute of Technology Delhi, New Delhi 110016, India. Electronic address:

Surface plasmon resonance (SPR) based dopamine sensor is realized using the state-of-art technique of molecular imprinting over an optical fiber substrate. Polypyrrole (PPy) is depicted as an effective polymer for the imprinting of dopamine through a green synthesis approach. Sensitivity of the probe is enhanced by the augmenting effect of surface imprinting of dopamine in polypyrrole over multiwalled carbon nanotubes (MWCNTs). Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.023DOI Listing

Molybdenum disulfide-integrated photonic barcodes for tumor markers screening.

Biosens Bioelectron 2019 May 11;133:199-204. Epub 2019 Mar 11.

Pancreatitis Center, Precision Medicine Center, and Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China. Electronic address:

As a new class of two-dimensional (2D) materials, molybdenum disulfide (MoS) has huge potential in biomedical area; while its applications in multiplex bioassays are still a challenge. Here, we present novel MoS-integrated silica colloidal crystal barcode (SCCB) for multiplex microRNA (miRNA) screening. MoS was adsorbed on SCCBs by electrostatic interaction, and quantum dots (QDs) decorated hairpin probes were coupled on MoS by covalent linkage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193021
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http://dx.doi.org/10.1016/j.bios.2019.02.066DOI Listing
May 2019
2 Reads

An electrochemical biosensor based on Hairpin-DNA modified gold electrode for detection of DNA damage by a hybrid cancer drug intercalation.

Biosens Bioelectron 2019 May 14;133:160-168. Epub 2019 Mar 14.

University of Central Florida. NanoBioelectrochemistry Laboratory, Department of Chemistry, University of Central Florida, 4000 Central Florida Blvd., Orlando, FL 32816, United States. Electronic address:

An efficient and new electrochemical biosensor for detection of DNA damage, induced by the interaction of the hybrid anti-cancer compound (7ESTAC01) with DNA, was studied by differential pulse voltammetry (DPV). The biosensor consists of a Stem-Loop DNA (SL-DNA) probe covalently attached to the gold electrode (GE) surface that hybridizes to a complementary DNA strand (cDNA) to form a double-stranded DNA (dsDNA). The interaction and DNA damage induced by 7ESTAC01 was electrochemically studied based on the oxidation signals of the electroactive nucleic acids on the surface of the GE by DPV. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193022
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http://dx.doi.org/10.1016/j.bios.2019.02.071DOI Listing
May 2019
8 Reads

Quench-type electrochemiluminescence immunosensor for detection of amyloid β-protein based on resonance energy transfer from luminol@SnS-Pd to Cu doped WO nanoparticles.

Biosens Bioelectron 2019 May 19;133:192-198. Epub 2019 Mar 19.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China; Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, PR China.

A highly efficient quench-type electrochemiluminescence (ECL) immunosensor was proposed for the trace detection of amyloid β-protein (Aβ). In this work, tin disulfide nanoflowers (SnS NFs) with large specific surface area, favorable catalytic property and chemical stability were prepared and used as substrate material. Taking advantage of the excellent catalytic ability and biocompatibility, palladium nanoparticles (Pd NPs) were in situ reduced on SnS NFs to obtain SnS-Pd. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.035DOI Listing
May 2019
1 Read

Multi-site dynamic recording for Aβ oligomers-induced Alzheimer's disease in vitro based on neuronal network chip.

Biosens Bioelectron 2019 May 14;133:183-191. Epub 2019 Mar 14.

Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China. Electronic address:

Alzheimer's disease (AD) is a chronic central neurodegenerative disease. The pathological features of AD are the extracellular deposition of senile plaques formed by amyloid-β oligomers (AβOs) and the intracellular accumulation of neurofibrillary tangles. However, due to the lack of effective method and experimental models to study the cognitive decline, communication at cell resolution and the implementation of interventions, the diagnosis and treatment on AD still progress slowly. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.025DOI Listing
May 2019
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An aptamer-based hook-effect-recognizable three-line lateral flow biosensor for rapid detection of thrombin.

Biosens Bioelectron 2019 May 19;133:177-182. Epub 2019 Mar 19.

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei University, Wuhan 430062, China; Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China. Electronic address:

In this paper, a three-line LFB was successfully developed by adding a thrombin line to a conventional two-line LFB for the detection of thrombin in a wide range of human serum. We introduced a thrombin line between the test line and the control line. The concentration of thrombin in the sample was quantitatively related to the signal formation on the three lines of the LFB. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.036DOI Listing

Integrated microfluidic pneumatic circuit for point-of-care molecular diagnostics.

Biosens Bioelectron 2019 May 12;133:169-176. Epub 2019 Mar 12.

Department of Biomedical Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104, Republic of Korea. Electronic address:

Developing simple, portable, rapid, and easy-to-use diagnostic technologies is essential for point-of-care (POC) blood molecular testing. Integrated microfluidic devices that include the functionalities of blood separation, microfluidic pumping, and molecular detection are desirable for POC testing; however, current technologies still rely on off-chip sample processing or require bulky equipment. We report a fully-integrated microfluidic diagnostic device, i. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.018DOI Listing
May 2019
1 Read

A novel ultrasensitive electrochemiluminescence biosensor for glutathione detection based on poly-L-lysine as co-reactant and graphene-based poly(luminol/aniline) as nanoprobes.

Biosens Bioelectron 2019 May 9;133:154-159. Epub 2019 Mar 9.

Key Laboratory of Applied Chemistry of Chongqing Municipality, Institute of Bioorganic and Medicinal Chemistry, Southwest University, 400715, China; School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address:

In this work, an ultrasensitive electrochemiluminescence (ECL) biosensor was constructed using poly-L-lysine (PLL) as a novel co-reactant of luminol and poly(luminol/aniline) nanorods loaded reduced graphene oxide (PLA@rGO) as nanoprobe, which enable highly sensitivity detection of glutathione (GSH). To the best of our knowledge, it is the first time that PLL was used for the co-reactant of luminol. Notably, about a 5-fold enhancement was obtained compared with the individual PLA@rGO using GCE. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.016DOI Listing

Label-free detection of Staphylococcus aureus bacteria using long-period fiber gratings with functional polyelectrolyte coatings.

Biosens Bioelectron 2019 May 14;133:147-153. Epub 2019 Mar 14.

Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, NJ 07030, United States. Electronic address:

Highly sensitive long-period fiber gratings (LPFG) was developed for label-free and rapid detection of Staphylococcus aureus (S. aureus). Specifically, the LPFG was functionalized with antibody and nanopitted polyelectrolyte coatings to facilitate bacterial adhesion and thus enhance the sensitivity of bacteria detection. Read More

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http://dx.doi.org/10.1016/j.bios.2019.03.024DOI Listing
May 2019
1 Read
6.409 Impact Factor