6,044 results match your criteria Biosecurity and bioterrorism : biodefense strategy practice and science[Journal]


Divergent geography of Wangata and Typhimurium epidemiology in New South Wales, Australia.

One Health 2019 Jun 9;7:100092. Epub 2019 Apr 9.

Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales, Australia.

serovar Wangata is an important cause of salmonellosis in the state of New South Wales, Australia. Standard surveillance has not identified a common food source and cases have been attributed to an unknown environmental or wildlife reservoir. Investigation of the spatial distribution of cases may provide valuable insights into local risk factors for infection and the potential role of the environment and wildlife. Read More

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http://dx.doi.org/10.1016/j.onehlt.2019.100092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475636PMC

Occurrence of trypanosome infections in cattle in relation to season, livestock movement and management practices of Maasai pastoralists in Northern Tanzania.

Vet Parasitol Reg Stud Reports 2018 05 22;12:91-98. Epub 2018 Feb 22.

School of Veterinary Science, Faculty of Science, The University of Sydney, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Australia. Electronic address:

African animal trypanosomosis (AAT) is a parasitic disease considered to be one of the greatest constraints to cattle production in Tanzania. There is insufficient information on seasonal occurrence of AAT and management practices in Monduli District of the Maasai Steppe ecosystem to guide and prioritize AAT control programs. A cross-sectional survey was undertaken in 10 randomly selected villages of Monduli District. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.02.007DOI Listing

Helminth infections in chickens (Gallus domesticus) raised in different production systems in Brazil.

Vet Parasitol Reg Stud Reports 2018 05 13;12:55-60. Epub 2018 Feb 13.

Universidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatuba, Rua Clóvis Pestana, 793, CEP 16050-680 Araçatuba, SP, Brazil. Electronic address:

The current study evaluated helminth infections in birds raised in different production systems for different purposes (extensive/dual-purpose, semi-intensive/broiler, semi-intensive/hen, intensive/hen and intensive/broiler) in Brazil. A total of 374 birds was assessed for helminths at necropsy using standard parasitological methods. During the necropsies, organs from the gastrointestinal tract (crop, esophagus, proventriculus, gizzard, small intestine, large intestine and ceca) of each bird were collected and the contents fixed in 70% ethanol. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.02.003DOI Listing

Genomic sequence analysis reveals diversity of Australian Xanthomonas species associated with bacterial leaf spot of tomato, capsicum and chilli.

BMC Genomics 2019 Apr 23;20(1):310. Epub 2019 Apr 23.

Agriculture Victoria Research Division, Department of Economic Development, Jobs, Transport & Resources, AgriBio, La Trobe University, Bundoora, Victoria, 3083, Australia.

Background: The genetic diversity in Australian populations of Xanthomonas species associated with bacterial leaf spot in tomato, capsicum and chilli were compared to worldwide bacterial populations. The aim of this study was to confirm the identities of these Australian Xanthomonas species and classify them in comparison to overseas isolates. Analysis of whole genome sequence allows for the investigation of bacterial population structure, pathogenicity and gene exchange, resulting in better management strategies and biosecurity. Read More

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http://dx.doi.org/10.1186/s12864-019-5600-xDOI Listing

Experimental Infection of Turkeys with A Virulent Newcastle Disease Virus Isolated from Broiler Chickens.

Arch Razi Inst 2019 Mar 1;74(1):51-57. Epub 2019 Mar 1.

Postgraduate Student of Avian Medicine, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Newcastle disease (ND) is a highly contagious infection of many avian species, mainly chickens and turkeys, with a devastating impact on worldwide poultry production. The ND accounts for heavy losses in Iranian poultry flocks. There are some reports regarding the epidemiology of this infection in Iran. Read More

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http://archrazi.areeo.ac.ir/article_114052.html
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http://dx.doi.org/10.22092/ari.2017.115524.1149DOI Listing
March 2019
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Food Services Using Energy- and Protein-Fortified Meals to Assist Vulnerable Community-Residing Older Adults Meet Their Dietary Requirements and Maintain Good Health and Quality of Life: Findings from a Pilot Study.

Geriatrics (Basel) 2018 Sep 12;3(3). Epub 2018 Sep 12.

National Health and Medical Research Council (NHMRC) Centre of Research Excellence in Translating Nutritional Science to Good Health, Discipline of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia.

The effects of "standard (STD)" vs. "protein- and energy-enriched (HEHP)" food-service meals on the nutrient intake, nutritional status, functional capacity, and wellbeing of older adults was investigated using a 12 week, double-blinded, parallel group design. All participants received dietetics counseling and either an STD (2. Read More

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http://dx.doi.org/10.3390/geriatrics3030060DOI Listing
September 2018

The relationship between food label use and dietary intake in adults: A systematic review.

Appetite 2019 Apr 19. Epub 2019 Apr 19.

Nutrition and Dietetics, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia. Electronic address:

Poor diet, resulting from high intake of ultra-processed packaged foods, is increasingly recognised as a key contributing factor to ill health. Food labels provide information on the nutritional content of packaged foods to consumers, which may influence consumption of nutrients such as energy, fat, saturated fat, trans-fats, sodium and added sugars. This review aims to summarise the current evidence for the association between use of food labels and dietary intake. Read More

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http://dx.doi.org/10.1016/j.appet.2019.03.025DOI Listing

Temporal, spatial and household dynamics of Typhoid fever in Kasese district, Uganda.

PLoS One 2019 22;14(4):e0214650. Epub 2019 Apr 22.

Department of Biosecurity Ecosystems and Veterinary Public Health, Makerere University, Kampala, Uganda.

Typhoid fever affects 21 million people globally, 1% of whom succumb to the disease. The social, economic and public health consequences of this disease disproportionately affect people in Africa and Asia. In order to design context specific prevention strategies, we need to holistically characterise outbreaks in these settings. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214650PLOS

Projecting impacts of global climate and land-use scenarios on plant biodiversity using compositional-turnover modelling.

Glob Chang Biol 2019 Apr 22. Epub 2019 Apr 22.

CSIRO Land and Water, Building 101, Black Mountain Laboratories, Clunies Ross St., Canberra, ACT, 2601, Australia.

Nations have committed to ambitious conservation targets in response to accelerating rates of global biodiversity loss. Anticipating future impacts is essential to inform policy decisions for achieving these targets, but predictions need to be of sufficiently high spatial resolution to forecast the local effects of global change. As part of the intercomparison of biodiversity and ecosystem services models of the IPBES, we present a fine-resolution assessment of trends in the persistence of global plant biodiversity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gcb.14663
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http://dx.doi.org/10.1111/gcb.14663DOI Listing
April 2019
1 Read

Serological Markers for Syphilis Among Persons Presenting with Syndromes Associated with Sexually Transmitted Infections Results from the Zimbabwe STI Etiology Study.

Sex Transm Dis 2019 Apr 17. Epub 2019 Apr 17.

University of Washington School of Medicine, Seattle, WA, USA.

Background: Syphilis prevalence in sub-Saharan Africa appears to be stable or declining but is still the highest globally. Ongoing sentinel surveillance in high-risk populations is necessary to inform management and detect changes in syphilis trends. We assessed serological syphilis markers among persons with sexually transmitted infections in Zimbabwe. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001006DOI Listing

Men who have sex with men with Mycoplasma genitalium-positive nongonococcal urethritis are more likely to have macrolide resistant strains than men with only female partners: a prospective study.

Sex Transm Dis 2019 Apr 17. Epub 2019 Apr 17.

Sydney Sexual Health Centre, Sydney, New South Wales, Australia Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR - NSW Health Pathology, Westmead, Australia Sydney Sexual Health Centre, Sydney, New South Wales, Australia; School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR - NSW Health Pathology, Westmead, Australia Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR - NSW Health Pathology, Westmead, Australia Western Sydney Sexual Health Centre, Parramatta, New South Wales, Australia Western Sydney Sexual Health Centre, Parramatta, New South Wales, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Australia.

Background: Mycoplasma genitalium was previously less common among men who have sex with men (MSM) compared with men with only female partners (MSW) in men with nongonococcal urethritis (NGU) in Sydney, Australia. We aimed to determine the prevalence of M. genitalium and of macrolide-resistant M. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001009DOI Listing
April 2019
1 Read

Misidentification of Risk Group 3/Security Sensitive Biological Agents by MALDI-TOF MS in Canada: November 2015-October 2017.

Can Commun Dis Rep 2018 May 3;44(5):110-115. Epub 2018 May 3.

Centre for Biosecurity, Public Health Agency of Canada, Ottawa, ON.

Background: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) is a technology increasingly used in diagnostic identification of microorganisms. However, anecdotal evidence suggests that this technology is associated with misidentification of Risk Group 3 (RG3)/Security Sensitive Biological Agents (SSBA) resulting in exposure risks to laboratory personnel.

Objective: To investigate and characterize incidents related to the use of MALDI-TOF MS in Canada between November 6, 2015, and October 10, 2017. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449105PMC

A method for generating virus-free cassava plants to combat viral disease epidemics in Africa.

Physiol Mol Plant Pathol 2019 Jan;105:77-87

Genetic Technologies International Limited (GTIL), P.O. Box 47430-00100, Nairobi, Kenya.

Here, we report a method to clean cassava plants from viral infections that cause cassava mosaic and brown streak diseases in Africa. Infected plants of resistant or tolerant varieties from Malawi, Mozambique, Kenya, Tanzania and Uganda were cleaned in the UK using a combination of tissue culture, chemotherapy and thermotherapy. In the first cycle of our virus-indexing procedure, we successfully cleaned 27 of the 31 varieties (87%), and after an additional three cleaning cycles, all plants were virus-free. Read More

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http://dx.doi.org/10.1016/j.pmpp.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472600PMC
January 2019

Generation of a highly attenuated strain of Pseudomonas aeruginosa for commercial production of alginate.

Microb Biotechnol 2019 Apr 21. Epub 2019 Apr 21.

Robert C. Byrd Biotechnology Science Center, Progenesis Technologies, LLC, One John Marshall Drive, Suite 314, Huntington, WV, 25755, USA.

Alginate is an important polysaccharide that is commonly used as a gelling agent in foods, cosmetics and healthcare products. Currently, all alginate used commercially is extracted from brown seaweed. However, with environmental changes such as increasing ocean temperature and the increasing number of biotechnological uses of alginates with specific properties, there is an emerging need for more reliable and customizable sources of alginate. Read More

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http://dx.doi.org/10.1111/1751-7915.13411DOI Listing
April 2019
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Characterization and genome analysis of a novel bacteriophage vB_SpuP_Spp16 that infects Salmonella enterica serovar pullorum.

Virus Genes 2019 Apr 19. Epub 2019 Apr 19.

College of Veterinary Medicine, Qingdao Agricultural University, Shandong, 266109, China.

A novel virulent bacteriophage vB_SpuP_Spp16 (hereafter designated Spp16) that infects Salmonella enterica serovar pullorum was isolated. Transmission electron microscopy showed that Spp16 possessed an isometric polyhedral head (60 nm in diameter) and a short tail (10 nm in length) belonging to the family Podoviridae. Its complete genome was determined to be 41,832 bp, with a 39. Read More

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http://dx.doi.org/10.1007/s11262-019-01664-0DOI Listing

Emergence of human infection with Jingmen tick virus in China: A retrospective study.

EBioMedicine 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address:

Background: A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans.

Methods: We obtained skin-biopsy, blood and serum samples from patients with tick bites, and used high-throughput sequencing, in situ hybridisation, and serologic testing to diagnose and ascertain the cases of JMTV infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193023
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http://dx.doi.org/10.1016/j.ebiom.2019.04.004DOI Listing
April 2019
4 Reads

Southeast Asia Strategic Multilateral Dialogue on Biosecurity.

Emerg Infect Dis 2019 May;25(5)

A strategic multilateral dialogue related to biosecurity risks in Southeast Asia, established in 2014, now includes participants from Singapore, Malaysia, Indonesia, Thailand, Philippines, and the United States. This dialogue is conducted at the nonministerial level, enabling participants to engage without the constraints of operating in their official capacities. Participants reflect on mechanisms to detect, mitigate, and respond to biosecurity risks and highlight biosecurity issues for national leadership. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-1659_article.htm
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http://dx.doi.org/10.3201/eid2505.181659DOI Listing
May 2019
2 Reads

Assessing Cyberbiosecurity Vulnerabilities and Infrastructure Resilience.

Front Bioeng Biotechnol 2019 29;7:61. Epub 2019 Mar 29.

Argonne National Laboratory (DOE), Strategic Security Sciences Division, Lemont, IL, United States.

The convergence of advances in biotechnology with laboratory automation, access to data, and computational biology has democratized biotechnology and accelerated the development of new therapeutics. However, increased access to biotechnology in the digital age has also introduced additional security concerns and ultimately, spawned the new discipline of cyberbiosecurity, which encompasses cybersecurity, cyber-physical security, and biosecurity considerations. With the emergence of this new discipline comes the need for a logical, repeatable, and shared approach for evaluating facility and system vulnerabilities to cyberbiosecurity threats. Read More

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00061
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http://dx.doi.org/10.3389/fbioe.2019.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455068PMC
March 2019
1 Read

Removal of a Subset of Non-essential Genes Fully Attenuates a Highly Virulent Strain.

Front Microbiol 2019 3;10:664. Epub 2019 Apr 3.

J. Craig Venter Institute, Rockville, MD, United States.

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent subspecies () can be fully attenuated targeted deletion of non-essential genes encoding, among others, potential virulence traits. Five genomic regions, representing approximately 10% of the original genome, were successively deleted using as an engineering platform. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00664
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http://dx.doi.org/10.3389/fmicb.2019.00664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456743PMC
April 2019
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Genome Sequence of a Staphylococcus xylosus Clinical Isolate, Strain SMA0341-04 (UGA5), from Siaya County Referral Hospital in Siaya, Kenya.

Microbiol Resour Announc 2019 Apr 18;8(16). Epub 2019 Apr 18.

Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

We report here the genome sequence of a clinical isolate, strain SMA0341-04 (UGA5), which contains one chromosome and at least one plasmid. Notably, strain SMA0341-04 (UGA5) contains the tetracycline efflux major facilitator superfamily (MFS) transporter () gene. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.01625-18
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http://dx.doi.org/10.1128/MRA.01625-18DOI Listing
April 2019
1 Read

APBioNet's annual International Conference on Bioinformatics (InCoB) returns to India in 2018.

BMC Genomics 2019 Apr 18;19(Suppl 9):266. Epub 2019 Apr 18.

Department of Molecular Sciences, Macquarie University, Sydney, NSW, 2109, Australia.

InCoB, one of the largest annual bioinformatics conferences in the Asia-Pacific region since its launch in 2002, returned to New Delhi, India after 12 years, with a conference attendance of 314 delegates. The 2018 conference had sessions on Big Data and Algorithms, Next Generation Sequencing and Omics Science, Structure, Function and Interactions, Disease and Drug Discovery and Plant and Agricultural Bioinformatics. The conference also featured an industry track as well as panel discussions on Women in Bioinformatics and Democratization vs. Read More

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http://dx.doi.org/10.1186/s12864-019-5582-8DOI Listing
April 2019
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Description of a Natural Infection with Decapod Iridescent Virus 1 in Farmed Giant Freshwater Prawn, .

Viruses 2019 Apr 17;11(4). Epub 2019 Apr 17.

Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences; Laboratory for Marine Fisheries Science and Food Production Processes, National Laboratory for Marine Science and Technology (Qingdao); Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs; Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Qingdao 266071, China.

is a valuable freshwater prawn in Asian aquaculture. In recent years, a new symptom that was generally called "white head" has caused high mortality in farms in China. Samples of , , , , , and Cladocera from a farm suffering from white head in Jiangsu Province were collected and analyzed in this study. Read More

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http://dx.doi.org/10.3390/v11040354DOI Listing

Consensus-based clinical research priorities for emergency nursing in Australia.

Australas Emerg Care 2018 May 12;21(2):43-50. Epub 2018 Apr 12.

Nursing and Midwifery Directorate Northern Sydney Local Health District, St Leonards, NSW, Australia; Faculty of Health, University of Technology Sydney, Sydney, Australia. Electronic address:

Introduction: Research is vital to responding to contemporary challenges of providing safe, high quality emergency nursing care, yet the research priorities for emergency nursing practice in Australia are unknown. This study aimed to establish research priorities for emergency nursing in Australia.

Methods: A two-stage descriptive, exploratory study was conducted. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2588994X183001
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http://dx.doi.org/10.1016/j.auec.2018.03.001DOI Listing
May 2018
2 Reads

The discovery of three new hare lagoviruses reveals unexplored viral diversity in this genus.

Virus Evol 2019 Jan 9;5(1):vez005. Epub 2019 Apr 9.

Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Our knowledge of mammalian viruses has been strongly skewed toward those that cause disease in humans and animals. However, recent metagenomic studies indicate that most apparently healthy organisms carry viruses, and that these seemingly benign viruses may comprise the bulk of virus diversity. The bias toward studying viruses associated with overt disease is apparent in the lagoviruses (family that infect rabbits and hares: although most attention has been directed toward the highly pathogenic members of this genus-rabbit haemorrhagic disease virus and European brown hare syndrome virus-a number of benign lagoviruses have also been identified. Read More

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https://academic.oup.com/ve/article/doi/10.1093/ve/vez005/54
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http://dx.doi.org/10.1093/ve/vez005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456799PMC
January 2019
1 Read

Surveillance of laboratory exposures to human pathogens and toxins: Canada 2017.

Can Commun Dis Rep 2018 Nov 1;44(11):297-304. Epub 2018 Nov 1.

Centre for Biosecurity, Public Health Agency of Canada, Ottawa, ON.

Background: Under Canada's and , the Public Health Agency of Canada (PHAC) is mandated with monitoring laboratory incident notifications through the Laboratory Incident Notification Canada (LINC) surveillance system. The year 2017 marks the second complete year of data.

Objective: To describe the laboratory exposure and laboratory-acquired infection incidents that occurred in Canada in 2017 by sector, human pathogens and toxins involved, number of affected persons, incident type and root causes. Read More

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https://www.canada.ca/content/dam/phac-aspc/documents/servic
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http://dx.doi.org/10.14745/ccdr.v44i11a05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449110PMC
November 2018
1 Read

Estimation of swine movement network at farm level in the US from the Census of Agriculture data.

Sci Rep 2019 Apr 17;9(1):6237. Epub 2019 Apr 17.

Department of Electrical & Computer Engineering, Kansas State University, Manhattan, Kansas, United States of America.

Swine movement networks among farms/operations are an important source of information to understand and prevent the spread of diseases, nearly nonexistent in the United States. An understanding of the movement networks can help the policymakers in planning effective disease control measures. The objectives of this work are: (1) estimate swine movement probabilities at the county level from comprehensive anonymous inventory and sales data published by the United States Department of Agriculture - National Agriculture Statistics Service database, (2) develop a network based on those estimated probabilities, and (3) analyze that network using network science metrics. Read More

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http://www.nature.com/articles/s41598-019-42616-w
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http://dx.doi.org/10.1038/s41598-019-42616-wDOI Listing
April 2019
1 Read

The Welfare of Cows in Indian Shelters.

Animals (Basel) 2019 Apr 16;9(4). Epub 2019 Apr 16.

Centre for Animal Welfare and Ethics, School of Veterinary Science, The University of Queensland, Gatton Campus, Australia 4343, Australia.

Cow shelters (gaushalas) are unique traditional institutions in India, where aged, infertile, diseased, rescued, and abandoned cows are sheltered for the rest of their life, until they die of natural causes. These institutions owe their existence to the reverence for the cow as a holy mother goddess for Hindus, the majority religion in India. There is a religious and legal prohibition on cow slaughter in most Indian states. Read More

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https://www.mdpi.com/2076-2615/9/4/172
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http://dx.doi.org/10.3390/ani9040172DOI Listing
April 2019
4 Reads

Genomic Sequences from Papua New Guinea: Lack of Genetic Connectivity with Northern Australian or East Timorese Genomes, and New Recombination Findings.

Plant Dis 2019 Apr 16:PDIS09181666RE. Epub 2019 Apr 16.

2 UWA Institute of Agriculture, Faculty of Science, The University of Western Australia, Crawley, WA, Australia.

(ZYMV) isolates were obtained in Papua New Guinea (PNG) from cucumber () or pumpkin ( spp.) plants showing mosaic symptoms growing at Kongop in the Mount Hagen District, Western Highlands Province, or Zage in the Goroka District, Eastern Highlands Province. The samples were blotted onto FTA cards, which were sent to Australia, where they were subjected to high-throughput sequencing. Read More

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http://dx.doi.org/10.1094/PDIS-09-18-1666-REDOI Listing

Decision-making in livestock biosecurity practices amidst environmental and social uncertainty: Evidence from an experimental game.

PLoS One 2019 17;14(4):e0214500. Epub 2019 Apr 17.

Department of Animal and Veterinary Sciences, University of Vermont, Burlington, Vermont, United States of America.

Livestock industries are vulnerable to disease threats, which can cost billions of dollars and have substantial negative social ramifications. Losses are mitigated through increased use of disease-related biosecurity practices, making increased biosecurity an industry goal. Currently, there is no industry-wide standard for sharing information about disease incidence or on-site biosecurity strategies, resulting in uncertainty regarding disease prevalence and biosecurity strategies employed by industry stakeholders. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214500PLOS

Albumin modified cationic nanocarriers to potentially create a new platform for drug delivery systems.

ACS Appl Mater Interfaces 2019 Apr 17. Epub 2019 Apr 17.

Cationic nanocarriers have emerged as promising nanoparticles systems for the effective delivery of nucleic acid and anticancer drugs to cancer cells. Positive charge is desirable for promoting cell internalization, while it also causes some adverse effects, such as toxicity and rapid clearance by mononuclear phagocytic systems. Herein, a new strategy of modifying cationic polymer micelles with albumin forming a protein corona to improve the surface physiochemical properties is reported. Read More

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http://pubs.acs.org/doi/10.1021/acsami.9b05599
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http://dx.doi.org/10.1021/acsami.9b05599DOI Listing
April 2019
2 Reads

Remote Sensing Data to Detect Hessian Fly Infestation in Commercial Wheat Fields.

Sci Rep 2019 Apr 16;9(1):6109. Epub 2019 Apr 16.

Department of Entomology, Kansas State University, Manhattan, KS, 66506, USA.

Remote sensing data that are efficiently used in ecological research and management are seldom used to study insect pest infestations in agricultural ecosystems. Here, we used multispectral satellite and aircraft data to evaluate the relationship between normalized difference vegetation index (NDVI) and Hessian fly (Mayetiola destructor) infestation in commercial winter wheat (Triticum aestivum) fields in Kansas, USA. We used visible and near-infrared data from each aerial platform to develop a series of NDVI maps for multiple fields for most of the winter wheat growing season. Read More

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http://dx.doi.org/10.1038/s41598-019-42620-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467867PMC

Network properties of salmonella epidemics.

Sci Rep 2019 Apr 16;9(1):6159. Epub 2019 Apr 16.

Centre for Complex Systems, Faculty of Engineering and IT, University of Sydney, Sydney, NSW, 2006, Australia.

We examine non-typhoidal Salmonella (S. Typhimurium or STM) epidemics as complex systems, driven by evolution and interactions of diverse microbial strains, and focus on emergence of successful strains. Our findings challenge the established view that seasonal epidemics are associated with random sets of co-circulating STM genotypes. Read More

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http://www.nature.com/articles/s41598-019-42582-3
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http://dx.doi.org/10.1038/s41598-019-42582-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467889PMC
April 2019
3 Reads

Can Sequence Phylogenies Safely Infer the Origin of the Global Virome?

MBio 2019 Apr 16;10(2). Epub 2019 Apr 16.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

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http://mbio.asm.org/lookup/doi/10.1128/mBio.00289-19
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http://dx.doi.org/10.1128/mBio.00289-19DOI Listing
April 2019
1 Read

Clonal Dispersal of VGII in an Endemic Region of Cryptococcosis in Colombia.

J Fungi (Basel) 2019 Apr 15;5(2). Epub 2019 Apr 15.

Microbiology Group, Instituto Nacional de Salud, Bogota 11321, Colombia.

This study characterized the genotype and phenotype of VGII isolates from Cucuta, an endemic region of cryptococcal disease in Colombia, and compared these traits with those from representative isolates from the Vancouver Island outbreak (VGIIa and VGIIb). Genetic diversity was assessed by multilocus sequence typing (MLST) analysis. Phenotypic characteristics, including growth capacity under different temperature and humidity conditions, macroscopic and microscopic morphology, phenotypic switching, mating type, and activity of extracellular enzymes were studied. Read More

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https://www.mdpi.com/2309-608X/5/2/32
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http://dx.doi.org/10.3390/jof5020032DOI Listing
April 2019
1 Read

Further characterisation of Leucocytozoon podargii in wild tawny frogmouths (Podargus strigoides) in Western Australia.

Parasitol Res 2019 Apr 15. Epub 2019 Apr 15.

School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, 6150, Australia.

The present study assessed the prevalence and morphology of Leucocytozoon podargii from wild tawny frogmouths (Podargus strigoides) in Western Australia (WA) and genetically characterised the cytochrome b gene (cyt b) of L. podargii in wild tawny frogmouths from WA and Queensland (QLD). The prevalence of L. Read More

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http://dx.doi.org/10.1007/s00436-019-06317-7DOI Listing

Characteristics of Selected Active Substances used in Disinfectants and their Virucidal Activity Against ASFV.

J Vet Res 2019 Mar 22;63(1):17-25. Epub 2019 Mar 22.

Department of Swine Diseases, National Veterinary Research Institute, 24-100 Puławy, Poland.

African swine fever (ASF), caused by African swine fever virus (ASFV), is currently one of the most important and serious diseases of pigs, mainly due to the enormous sanitary and socio-economic consequences. It leads to serious economic losses, not only because of the near 100% mortality rate, but also through the prohibitions of pork exports it triggers. Currently neither vaccines nor safe and effective chemotherapeutic agents are available against ASFV. Read More

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http://dx.doi.org/10.2478/jvetres-2019-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458555PMC

Changing landscapes of Southeast Asia and rodent-borne diseases: decreased diversity but increased transmission risks.

Ecol Appl 2019 Apr 15:e01886. Epub 2019 Apr 15.

CIRAD, UMR TETIS, F-34093, Montpellier, France.

The reduction in biodiversity from land use change due to urbanization and agricultural intensification appears to be linked to major epidemiological changes in many human diseases. Increasing disease risks and the emergence of novel pathogens result from increased contact among wildlife, domesticated animals, and humans. We investigated the relationship between human alteration of the environment and the occurrence of generalist and synanthropic rodent species in relation to the diversity and prevalence of rodent-borne pathogens in Southeast Asia, a hotspot of threatened and endangered species, and a foci of emerging infectious diseases. Read More

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http://dx.doi.org/10.1002/eap.1886DOI Listing

Aedes aegypti HPX8C modulates immune responses against viral infection.

PLoS Negl Trop Dis 2019 04 15;13(4):e0007287. Epub 2019 Apr 15.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Mosquitoes act as vectors of numerous pathogens that cause human diseases. Dengue virus (DENV) transmitted by mosquito, Aedes aegypti, is responsible for dengue fever epidemics worldwide with a serious impact on human health. Currently, disease control mainly relies on vector targeted intervention strategies. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007287
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http://dx.doi.org/10.1371/journal.pntd.0007287DOI Listing
April 2019
1 Read

Cyberbiosecurity: A New Perspective on Protecting U.S. Food and Agricultural System.

Front Bioeng Biotechnol 2019 29;7:63. Epub 2019 Mar 29.

Department of Agricultural and Applied Economics, Virginia Tech, Blacksburg, VA, United States.

Our national data and infrastructure security issues affecting the "bioeconomy" are evolving rapidly. Simultaneously, the conversation about cyber security of the U.S. Read More

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https://www.frontiersin.org/article/10.3389/fbioe.2019.00063
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http://dx.doi.org/10.3389/fbioe.2019.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450256PMC
March 2019
1 Read

Burden of measles in Nigeria: a five-year review of casebased surveillance data, 2012-2016.

Pan Afr Med J 2019 22;32(Suppl 1). Epub 2019 Jan 22.

Nigeria Field Epidemiology and Laboratory Training Program, Abuja, Nigeria.

Introduction: measles is a vaccine preventable, highly transmissible viral infection that affects mostly children under five years. We reviewed surveillance data on measles from Nigeria over a five-year period to highlights its burden and make recommendations for improvements.

Methods: we conducted a secondary data analysis of measles specific Integrated Disease Surveillance and Response (IDSR) records of all states in Nigeria over a five-year period. Read More

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http://www.panafrican-med-journal.com/content/series/32/1/5/
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http://dx.doi.org/10.11604/pamj.supp.2019.32.1.13564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445333PMC
April 2019
8 Reads

Methicillin-Resistant Nasal Colonization among Healthcare Workers at Kampala International University Teaching Hospital, Southwestern Uganda.

Can J Infect Dis Med Microbiol 2019 10;2019:4157869. Epub 2019 Mar 10.

Department of Microbiology, Faculty of Medicine, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.

Whereas is a pathogen, it colonizes healthy people as normal flora without causing any symptoms or illness. Probably because of greater exposure, healthcare workers (HCWs) are more colonized, serving as reservoir for endogenous infections as well as dissemination. In developing countries including Uganda, there is scarcity of the literature on carriage among HCWs, making infection control difficult. Read More

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https://www.hindawi.com/journals/cjidmm/2019/4157869/
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http://dx.doi.org/10.1155/2019/4157869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431477PMC
March 2019
2 Reads

Salivary α-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study.

Am J Clin Nutr 2019 Apr;109(4):1029-1037

Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.

Background: Several studies recently reported contradicting results regarding the link between amylase 1 (AMY1) copy numbers (CNs), obesity, and type 2 diabetes.

Objective: The aim of this study was to assess the impact of AMY1 CN on anthropometrics and glycemic outcomes in obese individuals following a 2-phase dietary weight loss intervention.

Methods: Using the paralog ratio test, AMY1 CNs were accurately measured in 761 obese individuals from the DiOGenes study. Read More

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http://dx.doi.org/10.1093/ajcn/nqy363DOI Listing

Disruption of SpoIIID decreases sporulation, increases extracellular proteolytic activity and virulence in Bacillus anthracis.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, 100071, China; College of Food Science and Technology, Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai Ocean University, No. 999, Huchenghuan Road, Shanghai, 201306, PR China. Electronic address:

Endospores are important for maintenance of the B. anthracis lifecycle and necessary for its effective spread between hosts. Our experiments with B. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.056DOI Listing
April 2019
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Contagious agalactia monitoring in caprine herds through regular bulk tank milk sampling.

J Dairy Sci 2019 Apr 10. Epub 2019 Apr 10.

Laboratoire de Lyon, UMR Mycoplasmoses des Ruminants, ANSES, Université de Lyon, F-69364, Lyon, France; VetAgro Sup, UMR Mycoplasmoses des Ruminants, Université de Lyon, F-69280, Marcy-L'étoile, France.

Surveillance and control of Mycoplasma spp. responsible for contagious agalactia (CA) in caprine herds are important challenges in countries with a large small-ruminant dairy industry. In the absence of any clinical signs, being able to determine the potential circulation of mycoplasmas within a herd could help to prevent biosecurity issues during animal exchanges between farms and improve health management practices. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00220302193033
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http://dx.doi.org/10.3168/jds.2018-15889DOI Listing
April 2019
5 Reads

The inhibitory effect of nisin on Mycobacterium avium ssp. paratuberculosis and its effect on mycobacterial cell wall.

J Dairy Sci 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathobiological Sciences, University of Wisconsin, Madison 53706. Electronic address:

Infection with Mycobacterium avium ssp. paratuberculosis (M. paratuberculosis) is a widespread problem in the United States and worldwide, and it constitutes a significant health problem for dairy animals with a potential effect on human health. Read More

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http://dx.doi.org/10.3168/jds.2018-16106DOI Listing

Transcriptional regulation of Yersinia pestis biofilm formation.

Microb Pathog 2019 Apr 10;131:212-217. Epub 2019 Apr 10.

Department of Transfusion, General Hospital of Central Theater Command, Wuhan, 430070, Hubei, China. Electronic address:

Yersinia pestis, the causative agent of plague, is transmitted primarily by infected fleas in nature. Y. pestis can produce biofilms that block flea's proventriculus and promote flea-borne transmission. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.011DOI Listing
April 2019
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Reversible Gene Expression Control in Using an Optimized CRISPRi System.

Appl Environ Microbiol 2019 Apr 12. Epub 2019 Apr 12.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China

Many genes in the bacterial pathogen , the causative agent of three plague pandemics, remain uncharacterized, greatly hampering the development of measures for plague prevention and control. Clustered regularly interspaced short palindromic repeats interference (CRISPRi) has been shown to be an effective tool for gene knockdown in model bacteria. In this system, a catalytically-dead Cas9 (dCas9) and a small guide RNA (sgRNA) form a complex, binding to the specific DNA target through base pairing, thereby impeding RNA polymerase binding and causing target gene repression. Read More

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http://dx.doi.org/10.1128/AEM.00097-19DOI Listing
April 2019
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SET domain containing 1B gene (SETD1B) is mutated in primary hepatic neuroendocrine tumors.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Beijing 302 Hospital/5th Medical Center of Chinese PLA General of Hospital, Beijing 100039, China.

Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequencing of 22 paired tissues from PHNET patients and identified 22 recurring mutations of somatic genes involved in the following activities: epigenetic modification (BPTF, MECP2 and WDR5), cell cycle (TP53, ATM, MED12, DIDO1 and ATAD5) and neural development (UBR4, MEN1, GLUL and GIGYF2). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32334
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http://dx.doi.org/10.1002/ijc.32334DOI Listing
April 2019
3 Reads

Virology at the Lorne Infection and Immunity Conference 2019.

Virol Sin 2019 Apr 11. Epub 2019 Apr 11.

CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong, VIC, 3220, Australia.

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http://dx.doi.org/10.1007/s12250-019-00115-2DOI Listing

Presence of Newcastle disease viruses of sub-genotypes Vc and VIn in backyard chickens and in apparently healthy wild birds from Mexico in 2017.

Virus Genes 2019 Apr 12. Epub 2019 Apr 12.

Southeast Poultry Research Laboratory, US National Poultry Research Center, 934 College Station Rd, Athens, GA, 30605, USA.

Virulent Newcastle disease viruses (NDV) have been present in Mexico since 1946, and recently, multiple outbreaks have been reported in the country. Here, we characterized eleven NDV isolated from apparently healthy wild birds and backyard chickens in three different locations of Jalisco, Mexico in 2017. Total RNA from NDV was reverse-transcribed, and 1285 nucleotides, which includes 3/4 of the fusion gene, was amplified and sequenced using a long-read MinION sequencing method. Read More

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http://dx.doi.org/10.1007/s11262-019-01663-1DOI Listing