709 results match your criteria Bioscience Trends[Journal]


Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has antibacterial and anti-biofilm activity against Streptococcus pyogenes in vitro.

Biosci Trends 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University.

Streptococcus pyogenes causes several infectious diseases such as tonsillitis, cellulitis, and streptococcal toxic shock syndrome. As antibiotics are used for the general treatment of S. pyogenes infection, cases of treatment failure due to drug-resistant bacteria have increased. Read More

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http://dx.doi.org/10.5582/bst.2019.01005DOI Listing

Living donor liver transplantation for a patient with a history of total gastrectomy.

Biosci Trends 2019 Apr 15. Epub 2019 Apr 15.

Department of Transplantation and Pediatric Surgery, Kumamoto University Graduate School of Medical Sciences.

Adhesions due to previous upper abdominal surgery may complicate later liver transplantation. Here we report successful living donor liver transplantation (LDLT) in a patient with a history of total gastrectomy. A 32-year-old Japanese woman developed end-stage liver failure due to alcoholic cirrhosis. Read More

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http://dx.doi.org/10.5582/bst.2019.01037DOI Listing
April 2019
3 Reads

Sperm DNA fragmentation valued by SCSA and its correlation with conventional sperm parameters in male partner of recurrent spontaneous abortion couple.

Biosci Trends 2019 Apr 11. Epub 2019 Apr 11.

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

The objective of this study is to evaluate the predictive value of sperm DNA fragmentation Index (DFI) in unexplained recurrent spontaneous abortion (RSA) and to investigate its correlation with conventional sperm parameters. Besides, we aimed to reveal the necessity of establishing a DFI clinical threshold of each laboratory for the prognostic diagnosis of RSA and establish our own DFI threshold. Semen samples were collected from male partners of RSA patients (n = 139) and healthy recent fathers (control, n = 200). Read More

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http://dx.doi.org/10.5582/bst.2018.01292DOI Listing
April 2019
2 Reads

Predictive value of some pro-oxidants in type 2 diabetes mellitus with vascular complications.

Biosci Trends 2019 Apr 8. Epub 2019 Apr 8.

Department of Chemistry and Biochemistry, Medical Faculty, Trakia University.

The study aims to analyze oxidative stress levels in circulation of some reactive molecules and products of biomolecular modification in type 2 diabetes mellitus (T2DM) with diabetes-specific vascular complications in order to determine their predictive value. Also, the alterations of their serum concentration with reference to disease characteristics were assessed. Reactive oxygen species (ROS), nitric oxide radicals (•NO), malondialdehyde (MDA), protein carbonyl (CO) and 8-hydroxydeoxyguanosin (8-OHdG) in serum were measured in 93 patients with T2DM with vascular complications, 94 control subjects and 16 diabetic patients who had no evidence of vascular disease. Read More

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http://dx.doi.org/10.5582/bst.2019.01020DOI Listing
April 2019
1 Read

Daucosterol induces autophagic-dependent apoptosis in prostate cancer via JNK activation.

Biosci Trends 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurosurgery, Hospital of Chengdu University of Traditional Chinese Medicine.

Plant sterols (phytosterols) have been widely accepted as a natural anti-cancer agent in multiple malignant tumors. This study was designed to investigate the functions of daucosterol in prostate cancer progression and its possible molecular mechanisms. Our results showed that daucosterol inhibited cell proliferation and induced cell cycle arrest. Read More

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http://dx.doi.org/10.5582/bst.2018.01293DOI Listing

A Clinical scoring model to predict mortality in HIV/TB co-infected patients at end stage of AIDS in China: An observational cohort study.

Biosci Trends 2019 Mar 29. Epub 2019 Mar 29.

Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University.

We construct and validate a non-invasive clinical scoring model to predict mortality in HIV/TB patients at end stage of AIDS in China. There were 1,007 HIV/TB patients admitted to Beijing Ditan Hospital from August 2009 to January 2018 included in this study, who were randomly assigned to form derivation cohort and validation cohort. A clinical scoring model was developed based on predictors associated with mortality identified with Cox proportional hazard models. Read More

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https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_201
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http://dx.doi.org/10.5582/bst.2018.01309DOI Listing
March 2019
3 Reads

IPS-1 polymorphisms in regulating interferon response in HBV infection.

Biosci Trends 2019 Mar 29. Epub 2019 Mar 29.

Department of Infectious Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine.

Single nucleotide polymorphisms (SNP) influence the outcome of antiviral therapy in chronic hepatitis B patients. Interferon β promoter stimulator 1 polymorphisms (IPS-1) regulate interferon (IFN) mediated viral clearance in hepatitis B virus (HBV) infection. In our study, HepG2 and HepG2. Read More

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http://dx.doi.org/10.5582/bst.2018.01304DOI Listing

Chinese herbal medicine for acute upper respiratory tract infections and reproductive safety: A systematic review.

Biosci Trends 2019 Mar 31. Epub 2019 Mar 31.

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

Acute upper respiratory tract infections (AURTIs) are common and self-limited in people with normal immunity but sometimes lead to poor clinical outcomes under specific conditions such as pregnancy if not treated appropriately. Chinese herbal medicines (CHM), which are widely used to treat AURTIs, have proven to be effective in preclinical and clinical studies. This review focuses on the bioactivities of typical CHM and the adverse reactions they cause, and especially issues with reproductive safety when treating AURTIs. Read More

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http://dx.doi.org/10.5582/bst.2018.01298DOI Listing
March 2019
2 Reads

Novel HDAC6 selective inhibitors with 4-aminopiperidine-1- carboxamide as the core structure enhanced growth inhibitory activity of bortezomib in MCF-7 cells.

Biosci Trends 2019 ;13(1):91-97

Department of Medicinal Chemistry, School of Pharmacy, Qingdao University.

In epigenetics, histone deacetylases (HDACs) are well validated targets for the development of anticancer drugs. In this work, we reported the design and synthesis of a series of twenty two novel (E)-N-hydroxycinnamamide-based HDAC inhibitors with 4-aminopiperidine1-carboxamide as the core structure. Most newly synthesized compounds displayed high inhibition rates toward HDAC at the concentration of 1 μM. Read More

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http://dx.doi.org/10.5582/bst.2019.01049DOI Listing
January 2019
1 Read

Preoperative evaluation of the degree of liver fibrosis based on matter-element analysis using serological indicators in patients with hepatocellular carcinoma.

Biosci Trends 2019 ;13(1):70-76

Department of Hepatopancreatobilary Surgery, The First College of Clinical Medical Sciences, Three Gorges University.

Evaluation of the degree of liver fibrosis is an important basis for the clinical diagnosis and treatment of patients with hepatocellular carcinoma (HCC). It is meaningful to make a preoperative evaluation with non-invasive methods. In the current study, 12 commonly used preoperative serological indicators from 161 HCC patients with different degree of liver fibrosis were collected retrospectively, and 8 of the indicators (ALB, PA, TBil, INR, AST, GGT, ALP, and PT) were ultimately used in matter-element analysis to create a formula. Read More

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http://dx.doi.org/10.5582/bst.2018.01311DOI Listing
January 2019
1 Read

Effects of BENC-511, a novel PI3K inhibitor, on the proliferation and apoptosis of A549 human lung adenocarcinoma cells.

Biosci Trends 2019 ;13(1):40-48

Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University.

The small chemical compound 8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene (S14161) was recently identified as an inhibitor of phosphoinositide 3-kinase (PI3K) and reported to inhibit tumor growth. However, its chiral structure and poor solubility prevent its further use. Compound 6-bromo-8-ethoxy-3-nitro-2H-chromene (BENC-511) is an analogue of S14161 produced by structural optimization. Read More

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http://dx.doi.org/10.5582/bst.2019.01006DOI Listing
January 2019

Improvement in the diagnosis and treatment of T2 gallbladder carcinoma is pivotal to improvement in the overall prognosis for this disease.

Biosci Trends 2019 ;13(1):1-9

Department of Oncology, XinHua Hospital, Shanghai Jiao Tong University.

Since the American Joint Committee on Cancer (AJCC) subdivided the T2 stage of gallbladder carcinoma (GBC) into T2a and T2b, the diagnosis and treatment of those stages have been a subject of heated discussion and controversy. T2 is a stage of GBC that might be treatable. Based on the extent of lymph node metastasis and distant metastasis, T2 GBC can be classified into various pathological stages such as IIA, IIB, IIIB, and IVB, leading to controversy in clinical settings. Read More

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http://dx.doi.org/10.5582/bst.2019.01039DOI Listing
January 2019
2 Reads

Combined machine learning and functional magnetic resonance imaging allows individualized prediction of high-altitude induced psychomotor impairment: The role of neural functionality in putamen and pallidum.

Biosci Trends 2019 Mar 27;13(1):98-104. Epub 2019 Feb 27.

Department of Occupational and Environmental Health, the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical University.

Hypoxia exposure during high-altitude expedition cause psychomotor impairment. Neuroimaging studies indicated that the impairment may be significantly associated with neuron loss and decreased regional homogeneity (ReHo) in several brain regions, suggesting the neural functionality in these regions may be utilized to predict psychomotor impairment under exposure. In this study, 69 subjects come from Shaanxi-Tibet immigrant cohort. Read More

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http://dx.doi.org/10.5582/bst.2019.01002DOI Listing
March 2019
1.663 Impact Factor

Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury.

Biosci Trends 2019 Mar 27;13(1):23-31. Epub 2019 Feb 27.

Department of General Surgery, Second Affiliated Hospital of Xi'an Jiaotong University.

Cholestasis is a pathological process in which bile drainage is poor for a variety of reasons. Many studies have shown that cholestatic liver injury is a neutrophil-mediated inflammatory response, and oxidative stress induced by neutrophils is the main mechanism of liver cell death. The literature summarizes the bile acid signaling pathway, the neutrophil chemotaxis recruitment process during cholestasis, and the oxidative stress damage produced by neutrophil activation, summarizes the latest research progress. Read More

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http://dx.doi.org/10.5582/bst.2018.01247DOI Listing

Prognosis for patients with hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) after surgical treatment.

Biosci Trends 2019 Mar 27;13(1):77-85. Epub 2019 Feb 27.

Department of Hepatobiliary Surgery, Zhangzhou Affiliated Hospital, Fujian Medical University.

Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is rarely seen in clinical practice, and its treatment strategies and prognosis are still a subject of debate. To ascertain the characteristics of and prognosis for HCC with BDTT, 49 patients with HCC with BDTT were studied out of 763 consecutive patients with HCC who underwent surgical treatment from July 2004 to May 2018. The clinical characteristics of and prognosis for those 49 patients were reviewed and analyzed retrospectively. Read More

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http://dx.doi.org/10.5582/bst.2018.01234DOI Listing

Efficacy and safety of external-beam radiation therapy for hepatocellular carcinoma: An overview of current evidence according to the different target population.

Biosci Trends 2019 Mar 24;13(1):10-22. Epub 2019 Feb 24.

Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area).

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. During the recent years, external-beam radiation therapy (EBRT) has been safely and effectively employed for the management of HCC. We overviewed the current evidence regarding the efficacy and safety of EBRT for HCC according to the different target population. Read More

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http://dx.doi.org/10.5582/bst.2018.01261DOI Listing

Programmed death ligand-1, tumor infiltrating lymphocytes and HLA expression in Chinese extrahepatic cholangiocarcinoma patients: Possible immunotherapy implications.

Biosci Trends 2019 Mar 15;13(1):58-69. Epub 2019 Feb 15.

School of Clinical Medicine, Tsinghua University.

Immunotherapy might be an effective treatment in extrahepatic cholangiocarcinoma (eCCA), a tumor with extremely limited therapeutic options. Our study is to characterize the programmed death ligand-1 (PD-L1) protein expression and cancer microenvironment profiles in surgically resected eCCA samples. PD-L1 positivity was observed on tumor cells (32. Read More

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http://dx.doi.org/10.5582/bst.2019.01003DOI Listing
March 2019
1 Read
1.663 Impact Factor

By regulating miR-182-5p/BCL10/CYCS, sufentanil reduces the apoptosis of umbilical cord mesenchymal stem cells caused by ropivacaine.

Biosci Trends 2019 Mar 17;13(1):49-57. Epub 2019 Feb 17.

Obstetrics and Gynecology Hospital of Fudan University.

Sufentanil is a type of opioid analgesic and is usually used to facilitate painless labor in combination with the local anesthetic ropivacaine. One aim of the current study was to investigate the effects of sufentanil and ropivacaine on umbilical cord mesenchymal stem cells (UCMSCs). A second aim of this study was to determine whether sufentanil attenuated the cytotoxicity of ropivacaine in vitro. Read More

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http://dx.doi.org/10.5582/bst.2018.01291DOI Listing
March 2019
2 Reads

Fibrosis-4 index predicts mortality in HIV/HCV co-infected patients receiving combination antiretroviral therapy in rural China.

Biosci Trends 2019 Mar 5;13(1):32-39. Epub 2019 Feb 5.

Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University.

End-stage liver disease (ESLD) is among leading causes of death for people living with HIV and HCV. Little is known how liver fibrosis score predicts mortality in HIV/HCV co-infected population under combination antiretroviral therapy (cART). A retrospective cohort study of 691 HIV/HCV co-infected patients receiving cART in Yunnan, China from 2005 to 2016 was carried out to explore the association between Fibrosis-4 index (FIB-4) and all-cause mortality. Read More

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https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_201
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http://dx.doi.org/10.5582/bst.2018.01299DOI Listing
March 2019
8 Reads

Structural analyses of a hemolytic compound found in an extract of Hypsizygus marmoreus fruiting bodies at a low pH.

Biosci Trends 2019 Mar 30;13(1):86-90. Epub 2019 Jan 30.

Department of Applied Biochemistry, Tokai University.

The current study determined the structure of a hemolytic compound found in an extract from the fruiting bodies of the edible mushroom Hypsizygus marmoreus when its pH was lowered. The hemolytic compound was purified using the modified Bligh and Dyer method followed by chromatography using reversed phase and silica gel columns. Structural analyses of the purified hemolytic compound were performed using NMR and ESI-MS. Read More

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http://dx.doi.org/10.5582/bst.2019.01008DOI Listing

"History, Tradition, and Progress": The ceremony of 150 Anniversary of the National Center for Global Health and Medicine held in Tokyo, Japan.

Biosci Trends 2019 Mar 25;13(1):105-106. Epub 2019 Jan 25.

National Center for Global Health and Medicine.

"History, Tradition, and Progress", a grand ceremony in celebration of the 150 Anniversary of the National Center for Global Health and Medicine (NCGM) was held in Tokyo, Japan on December 3, 2018. Hundreds of distinguished guests from home and abroad attended the grand ceremony. The NCGM is a national research and development agency, which is a type of independent administrative entity. Read More

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https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_201
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http://dx.doi.org/10.5582/bst.2019.01018DOI Listing
March 2019
6 Reads

Prevention of mother-to-child transmission (PMTCT) continues to play a vital role in the response to HIV/AIDS: Current status and future perspectives.

Biosci Trends 2019 Mar 25;13(1):107-109. Epub 2019 Jan 25.

Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University.

Prevention of mother-to-child transmission (PMTCT) program offer a range of services for women of reproductive age living with or at risk of contracting the human immunodeficiency virus (HIV) in order to maintain their health and to protect their infants from acquiring HIV. The program has made significant progress in eliminating HIV. Thanks to the provision of PMTCT services, around 1. Read More

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http://dx.doi.org/10.5582/bst.2019.01009DOI Listing

Comparative study of preciseness in the regional variation of influenza in Japan among the National Official Sentinel Surveillance of Infectious Diseases and the National Database of Electronic Medical Claims.

Biosci Trends 2018 ;12(6):636-640

School of Pharmacy, Nihon University.

In Japan, national official surveillance for influenza has been performed at about 5,000 sentinel hospitals/clinics by the National Official Sentinel Surveillance of Infectious Diseases (NOSSID). Meanwhile, all electronic medical claims nationwide in the National Database of Electronic Medical Claims (NDBEMC) were recently disclosed by the Ministry of Health, Labour and Welfare of Japan. We compared the regional variation of influenza incidence among prefectures between the NOSSID and NDBEMC. Read More

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http://dx.doi.org/10.5582/bst.2018.01279DOI Listing
January 2018
1 Read

Purification, crystallization and preliminary X-ray crystallographic studies on the C-terminal domain of the flagellar protein FliL from Helicobacter pylori.

Biosci Trends 2018 ;12(6):630-635

Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University.

FliL is an inner membrane protein, occupying a position between the rotor and the stator of the bacterial flagellar motor. Its proximity to, and interactions with, the MS (membrane and supramembranous) ring, the switch complex and the stator proteins MotA/B suggests a role in recruitment and/or stabilization of the stator around the rotor, although the precise role of FliL in the flagellum remains to be established. In this study, recombinant C-terminal domain of Helicobacter pylori FliL (amino-acid residues 81-183) has been expressed in Escherichia coli and purified to > 98% homogeneity. Read More

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http://dx.doi.org/10.5582/bst.2018.01218DOI Listing
January 2018
1 Read

A freeze-and-thaw method to reuse agarose gels for DNA electrophoresis.

Authors:
Noboru Sasagawa

Biosci Trends 2018 ;12(6):627-629

Department of Applied Biochemistry, School of Engineering, Tokai University.

A novel protocol to reuse agarose following agarose gel electrophoresis was established in this study. By repeated freeze-and-thaw of the agarose gel, ethidium bromide and other buffer components in the gel were safely removed from the gel without generation of any toxic fume. The agarose recovered using this method can be used for further electrophoretic experiments without any issues. Read More

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http://dx.doi.org/10.5582/bst.2018.01267DOI Listing
January 2018

En bloc resection for intra-abdominal/retroperitoneal desmoid-type fibromatosis with adjacent organ involvement: A case series and literature review.

Biosci Trends 2018 ;12(6):620-626

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Hepato-PancreatoBiliary Surgery, Peking University Cancer Hospital and Institute.

Surgical treatment for intra-abdominal/retroperitoneal desmoid-type fibromatosis (IA/RPDF) is still controversial. Studies regarding en bloc resection in IA/RPDF with adjacent organ involvement are scanty. This study aims to evaluate the safety and effectiveness of en bloc resection in IA/RPDF with adjacent organ involvement. Read More

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http://dx.doi.org/10.5582/bst.2018.01285DOI Listing
January 2018

Integrating multiple of the median values of serological markers with the risk cut-off value in Down syndrome screening.

Biosci Trends 2018 ;12(6):613-619

Obstetrics and Gynecology Hospital of Fudan University.

To assess the predictive value of integrating multiple of the median (MOM) with the risk cut-off value for serological screening of Down syndrome. In this retrospective study, women with singleton pregnancies who underwent triple serological screening for Down syndrome were followed, and their screening results and pregnancy outcomes were recorded. The range of MoM value of each indicator was calculated, different protocols integrating various MoM values with the risk cut-off value were compared. Read More

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https://www.jstage.jst.go.jp/article/bst/12/6/12_2018.01232/
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http://dx.doi.org/10.5582/bst.2018.01232DOI Listing
January 2018
10 Reads

Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis.

Biosci Trends 2018 ;12(6):587-594

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.

Obesity has become a severe public health problem worldwide. Crocin, a natural product, has been reported to have a number of pharmacological activities, including anti-inflammatory, anti-cancer, neuroprotective, antihypertensive, and cardioprotective action. The aims of the current study were to identify the beneficial effects of crocin on obesity, adipocyte differentiation, and lipolysis and to evaluate the possible role of AMPK. Read More

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https://www.jstage.jst.go.jp/article/bst/12/6/12_2018.01240/
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http://dx.doi.org/10.5582/bst.2018.01240DOI Listing
January 2018
10 Reads

The effect of His-tag and point mutation on the activity of irisin on MC3T3-E1 cells.

Biosci Trends 2018 ;12(6):580-586

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University; The Joint Laboratory for Reproductive Medicine of Sichuan University-The Chinese University of Hong Kong; Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education; Reproductive Endocrinology and Regulation Laboratory, West China Second University Hospital, Sichuan University.

Irisin is a myokine secreted from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) and has an effect on bone formation. There are limited studies about the structure of irisin and its functional unit. In order to clarify the candidate domain responsible for irisin action, we constructed several irisin variants and tested their influence on the proliferation and osteogenesis of MC3T3-E1 cells. Read More

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https://www.jstage.jst.go.jp/article/bst/12/6/12_2018.01207/
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http://dx.doi.org/10.5582/bst.2018.01207DOI Listing
January 2018
5 Reads

Stent placement for benign portal vein stenosis following pancreaticoduodenectomy in a hybrid operating room.

Biosci Trends 2019 Jan 28;12(6):641-644. Epub 2018 Dec 28.

Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.

Benign portal vein stenosis is a rare complication following pancreaticoduodenectomy. Because a direct surgical approach to the portal vein is difficult due to severe adhesions following pancreaticoduodenectomy, portal vein stent placement is considered a good treatment option. Herein, we report 3 cases of severe portal vein stenosis following pancreaticoduodenectomy that were treated with portal venous stent placement in a hybrid operating room, combining a conventional operating room with an angiography suite. Read More

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http://dx.doi.org/10.5582/bst.2018.01296DOI Listing
January 2019
2 Reads

Danzhi Jiangtang Capsule ameliorates kidney injury via inhibition of the JAK-STAT signaling pathway and increased antioxidant capacity in STZ-induced diabetic nephropathy rats.

Biosci Trends 2019 Jan 28;12(6):595-604. Epub 2018 Dec 28.

Department of Endocrinology, the First Affiliated Hospital of Anhui University of TCM.

Danzhi Jiangtang Capsule (DJC), a traditional Chinese medicinal formula, has been used clinically in treating diabetes and diabetic nephropathy (DN). We previously demonstrated that DJC is capable of improving renal function in patients and rats with DN, but the mechanisms underlying these therapeutic benefits of DJC are not quite clear yet. In this study, STZ-induced diabetic rats were orally administered DJC for 8 weeks. Read More

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https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_201
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http://dx.doi.org/10.5582/bst.2018.01255DOI Listing
January 2019
18 Reads
1.663 Impact Factor

Regulation on introducing process of the highly difficult new medical technologies: A survey on the current status of practice guidelines in Japan and overseas.

Biosci Trends 2019 Jan 28;12(6):560-568. Epub 2018 Dec 28.

Departments of Gastrointestinal Tract Surgery, Fukushima Medical University.

Since serious problematic cases regarding the technical safety of technically demanding operations were reported in Japan, the Ministry of Health, Labor and Welfare issued new regulations on June 10, 2016 requiring each hospital to check the status of informed consent, skill of surgery team and governance system of the surgical unit, when the highly difficult new medical technologies were introduced to a hospital. In order to firmly establish this new system for highly difficult new medical technologies, it is very important and informative to survey the current situation for guidelines and consensus regarding introduction of medical technology with special skills in Japan and overseas. Based on the survey of questionnaires, document retrieval, and expert interviews, we found that documentation related to the introduction process of highly difficult medical technologies is very rare, and the regulations were mainly issued by academic societies. Read More

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http://dx.doi.org/10.5582/bst.2018.01226DOI Listing
January 2019
2 Reads

The beneficial and deleterious role of dietary polyphenols on chronic degenerative diseases by regulating gene expression.

Biosci Trends 2019 Jan 28;12(6):526-536. Epub 2018 Dec 28.

Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University.

Dietary polyphenols, a natural component in many kinds of foods such as fruits and vegetables, play essential roles in a wide range of plant functions. Importantly, the discovery of the functions of polyphenols including anti-oxidant, anti-carcinogenic and anti-inflammatory has been appealing to researchers' attentions. Dietary polyphenols have shown protective effects on chronic degenerative diseases (CDD) such as cardiovascular diseases, cancers, and neurodegenerative diseases by regulating gene expression. Read More

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http://dx.doi.org/10.5582/bst.2018.01172DOI Listing
January 2019

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes.

Biosci Trends 2019 Jan 22;12(6):605-612. Epub 2018 Dec 22.

Department of Orthopedic surgery, Zhongshan Hospital, Fudan University.

Mitochondrial damage is involved in the pathogenesis of osteoarthritis. Metformin, one of the most common prescriptions for patients with type 2 diabetes, can reportedly activate Sirtuin 3 (SIRT3) expression which protects mitochondria from oxidative stress. In this study, we investigated the inhibitory property of metformin on mitochondrial damage by focusing on the interleukin-1 beta (IL-1β)-stimulated osteoarthritis model by using primary murine chondrocytes. Read More

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http://dx.doi.org/10.5582/bst.2018.01263DOI Listing
January 2019
4 Reads

On medical application of neural networks trained with various types of data.

Biosci Trends 2019 Jan 17;12(6):553-559. Epub 2018 Dec 17.

Department of International Trial, Center for Clinical Sciences; Hospital International Health Care Center, National Center for Global Health and Medicine.

Neural networks have garnered attention over the past few years. A neural network is a typical model of machine learning that is used to identify visual patterns. Neural networks are used to solve a wide variety of problems, including image recognition problems and time series prediction problems. Read More

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https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_201
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http://dx.doi.org/10.5582/bst.2018.01264DOI Listing
January 2019
11 Reads

Update review of skin adverse events during treatment of lung cancer and colorectal carcinoma with epidermal growth receptor factor inhibitors.

Biosci Trends 2019 Jan 17;12(6):537-552. Epub 2018 Dec 17.

Department of Integrative Oncology, China-Japan Friendship Hospital.

The past decades have witnessed a rapid increase in the use of molecularly targeted therapies. One class of agents includes the epidermal growth factor receptor inhibitors (EGFRIs), which afford patients longer progression-free survival (PFS) times, especially among non-small cell lung cancer (NSCLC) and metastatic colorectal carcinoma (mCRC). Certain adverse effects, particularly skin toxicity, are mainly manifested as rash, xerosis, pruritus, nails changes, hair changes and mucositis. Read More

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http://dx.doi.org/10.5582/bst.2018.01246DOI Listing
January 2019
8 Reads

Tissue-specific alternative splicing of pentatricopeptide repeat (PPR) family genes in Arabidopsis thaliana.

Biosci Trends 2019 Jan 17;12(6):569-579. Epub 2018 Dec 17.

School of Materials Science, Japan Advanced Institute of Science and Technology (JAIST).

Alternative splicing is a post- and co-transcriptional regulatory mechanism of gene expression. Pentatricopeptide repeat (PPR) family proteins were recently found to be involved in RNA editing in plants. The aim of this study was to investigate the tissue-specific expression and alternative splicing of PPR family genes and their effects on protein structure and functionality. Read More

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http://dx.doi.org/10.5582/bst.2018.01178DOI Listing
January 2019

Prescription surveillance for early detection system of emerging and reemerging infectious disease outbreaks.

Biosci Trends 2018 ;12(5):523-525

School of Pharmacy, Nihon University.

Based on prescriptions filled at external pharmacies, prescription surveillance (PS) in Japan has been reporting the estimated numbers of influenza and varicella patients and people prescribed certain drugs since 2009. Every morning, this system estimates the numbers of patients from the numbers of prescriptions filled nationwide for neuraminidase inhibitors, anti-herpes virus drugs, antibiotic drugs, antipyretic analgesics, and multi-ingredient cold medications. Moreover, it can detect "unexplained" infectious diseases that are not explained as infectious diseases monitored by other surveillance systems. Read More

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http://dx.doi.org/10.5582/bst.2018.01201DOI Listing
January 2018
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The relation between social cohesion and the care burden of family healthcare providers.

Biosci Trends 2018 ;12(5):520-522

Department of Nursing, Tokyo Ariake University of Medical and Health Sciences.

This study aimed to clarify the relationship between social cohesion and family care burden. The social capital indicators of Kondo et al. and the short version of the Zarit Care Burden Interview Scale in Japanese (J-ZBI_8) were used. Read More

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http://dx.doi.org/10.5582/bst.2018.01175DOI Listing
January 2018
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Correlation between the use of antibiotics and development of a resistant bacterial infection in patients in the ICU.

Biosci Trends 2018 ;12(5):517-519

Clinical Laboratory, Qilu Hospital Affiliated with Shandong University.

The current study analyzed the correlation between the use of antibiotics and development of a resistant bacterial infection in 454 patients in intensive care units (ICUs), and this study also examined factors related to development of an infection in order to facilitate more rational use of antibiotics and to reduce the incidence of resistant bacterial infections. Potential subjects were patients who were admitted to the ICU in 2016, and 454 such patients were selected using cluster sampling. Patient information was documented using an original questionnaire, Patients in the ICU with a Resistant Bacterial Infection. Read More

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http://dx.doi.org/10.5582/bst.2018.01130DOI Listing
January 2018
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The importance of non-tuberculous mycobacteria identification in Chinese patients infected with HIV.

Biosci Trends 2018 ;12(5):515-516

Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University.

The increased co-incidence of tuberculosis (TB) and AIDS is compounded by the emergence of opportunistic infections with non-tuberculous mycobacteria (NTM) in patients with HIV/AIDS, and the treatment for these infections differs from that for TB. The high frequency of NTM strains found in patients infected with HIV raises concerns about accurate species identification before deciding proper treatment. A total of 101 isolates from 2014, 137 from 2015, and 162 from 2016 were subjected to 16S rDNA sequencing to identify the species. Read More

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https://www.jstage.jst.go.jp/article/bst/12/5/12_2018.01254/
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http://dx.doi.org/10.5582/bst.2018.01254DOI Listing
January 2018
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Considerations on PCR-based methods for malaria diagnosis in China malaria diagnosis reference laboratory network.

Biosci Trends 2018 ;12(5):510-514

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Key Laboratory of Parasite and Vector Biology, Ministry of Health.

Precise diagnosis is a key measurement for malaria control and elimination, traditional microscopy and rapid diagnostic tests cannot satisfy the requirements especially in the low transmission endemic areas or in the malaria elimination phase. Polymerase chain reaction (PCR) with high sensitivity and specificity can be considered as a diagnostic standard while no uniform PCR assay was established due to variations in their performance and lack of formal external quality assurance programs for validation for PCR assays in use. Here, 24 articles including 43 paired comparative evaluations limited to paired comparison of diagnostic performance between real-time PCR and conventional PCR to detect plasmodium in blood samples of human subjects from clinics or the field are systematically summarized. Read More

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http://dx.doi.org/10.5582/bst.2018.01198DOI Listing
January 2018
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HIV/AIDS responses in China should focus on the impact of global integration.

Authors:
Qi Tang Hongzhou Lu

Biosci Trends 2018 ;12(5):507-509

Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University.

China has made substantial progress in tackling its Human immunodeficiency virus (HIV) epidemic, however, the number of people living with HIV / acquired immunodeficiency syndrome (AIDS) continues to increase, with the number of all-cause deaths rising. There are a total 75.6 million people living with HIV and 2. Read More

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http://dx.doi.org/10.5582/bst.2018.01269DOI Listing
January 2018
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Novel compound heterozygous mutations in SLC26A4 gene in a Chinese family with enlarged vestibular aqueduct.

Biosci Trends 2018 ;12(5):502-506

Beijing Tongren Hospital, Capital Medical University; Beijing Institute of Otolaryngology; Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education.

In order to investigate the genetic causes of hearing loss in a Chinese proband with nonsyndromic hearing loss and enlarged vestibular aqueduct (EVA), we conducted clinical and genetic evaluations in a deaf proband and her parents with normal hearing. 20 exons and flanking splice sites of the SLC26A4 gene were screened for pathogenic mutations by PCR amplification and bidirectional sequencing. As a control, a group of 400 healthy newborns from the same ethnic background were subjected to SLC26A4 gene screening using the same method. Read More

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https://www.jstage.jst.go.jp/article/bst/12/5/12_2018.01260/
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http://dx.doi.org/10.5582/bst.2018.01260DOI Listing
January 2018
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Bao Yuan decoction and Tao Hong Si Wu decoction improve lung structural remodeling in a rat model of myocardial infarction: Possible involvement of suppression of inflammation and fibrosis and regulation of the TGF-β1/Smad3 and NF-κB pathways.

Biosci Trends 2018 ;12(5):491-501

Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.

Chronic heart failure (CHF) leads to pulmonary structural remodeling, which may be a key factor for poor clinical outcomes in patients with end-stage heart failure, and few effective therapeutic options are presently available. The aim of the current study was to explore the mechanism of action and pulmonary-protective effects of treatment with Bao Yuan decoction combined with Tao Hong Si Wu decoction (BYTH) on lung structural remodeling in rats with ischemic heart failure. In a model of myocardial infarction (MI) induced by ligation of the left anterior descending (LAD) artery, rats were treated with BYTH. Read More

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http://dx.doi.org/10.5582/bst.2018.01242DOI Listing
January 2018
9 Reads

Total laparoscopic versus robot-assisted laparoscopic pancreaticoduodenectomy.

Biosci Trends 2018 ;12(5):484-490

Department of Hepaticobiliarypancreatic and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, People's hospital of Hangzhou medical college.

In this study, the clinical effectiveness of the robot-assisted laparoscopic pancreatico-duodenectomy (RPD) and Total laparoscopic pancreaticoduodenectomy LPD were retrospectively reviewed. From December 2013 to September 2017, 20 patients underwent robot-assisted laparoscopic pancreaticoduodenectomy and 80 patients underwent Total laparoscopic pancreaticoduodenectomy. The clinical data of the RPDs and the first 20 LPDs were reviewed retrospectively. Read More

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https://www.jstage.jst.go.jp/article/bst/12/5/12_2018.01236/
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http://dx.doi.org/10.5582/bst.2018.01236DOI Listing
January 2018

Impact of three-dimensional visualization technology on surgical strategies in complex hepatic cancer.

Biosci Trends 2018 ;12(5):476-483

Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University.

Surgical resection is still the mainstay of treatment for primary liver cancer (PLC). It is unclear whether three-dimensional visualization (3DV) preoperative evaluation and simulated liver resection would affect the surgical strategies and improve the R0 resection rates of patients with complex PLC when compared with the 2D evaluation using computed tomography or magnetic resonance imaging. In the study, patients with complex PLC who were subjected to laparotomy underwent both 2D and 3DV evaluation before operation. Read More

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http://dx.doi.org/10.5582/bst.2018.01194DOI Listing
January 2018
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A novel compound heterozygous mutation in the GJB2 gene is associated with non-syndromic hearing loss in a Chinese family.

Biosci Trends 2018 ;12(5):470-475

Department of Cellular Biology and Genetics, Hunan Provincial Key Laboratory of Dong Medicine, Hunan University of Medicine.

Autosomal recessive (AR) non-syndromic hearing loss (NSHL) is the most common form of hereditary deafness. Mutations in the gap junction protein beta 2 (GJB2) gene encoding connexin 26 (Cx26) account for about 50% of cases of ARNSHL. In the current study, a combination of exome sequencing and Sanger sequencing in a Chinese Dong family with ARNSHL allowed identification of a novel compound heterozygous mutation c. Read More

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https://www.jstage.jst.go.jp/article/bst/12/5/12_2018.01156/
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http://dx.doi.org/10.5582/bst.2018.01156DOI Listing
January 2018
13 Reads

The pregnancy outcomes of intrauterine insemination with husband's sperm in natural cycles versus ovulation stimulated cycles: A retrospective study.

Biosci Trends 2018 ;12(5):463-469

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

To compare the clinical outcomes of intrauterine insemination (IUI) with or without ovulation induction (OI), IUI cycles from January 2008 to December 2017 in Zhoushan Maternity and Child Healthcare Hospital were included, consisting of 455 natural cycles and 536 OI cycles. The overall clinical pregnancy rate did not differ between the two groups (P > 0.05). Read More

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http://dx.doi.org/10.5582/bst.2018.01164DOI Listing
January 2018
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Differential expression of APE1 in hepatocellular carcinoma and the effects on proliferation and apoptosis of cancer cells.

Biosci Trends 2018 ;12(5):456-462

Oncology Surgery Department, Beijing Shijitan Hospital, Capital Medical University (Peking University Ninth School of Clinical Medicine).

This research aimed to investigate the differential expression of apurinic-apyrimidinic endonuclease 1 (APE1) in hepatocellular carcinoma (HCC) tissues and cells and the effects on proliferation and apoptosis of cancer cells. Immunohistochemical techniques were used to detect the expression of APE1 in 80 cases of HCC and the corresponding paracancerous tissue microarrays; meanwhile, Western blots were used to detect the expression of APE1 in both human HCC BEL-7402, BEL-7405, HCC-9204, Hep3B, HepG2, SMMC-7721 and Huh-7 cells, and normal hepatocyte L-02 cells. The relationship between APE1 expression and clinical pathological characteristics of HCC was statistically analyzed. Read More

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https://www.jstage.jst.go.jp/article/bst/12/5/12_2018.01239/
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http://dx.doi.org/10.5582/bst.2018.01239DOI Listing
January 2018
5 Reads