811 results match your criteria Bioscience Trends[Journal]


Insecticide Resistance of Aedes albopictus in Zhejiang Province, China.

Biosci Trends 2020 Jun 27. Epub 2020 Jun 27.

Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.

From 2003 until 2018, a total of 12 outbreaks with 1,654 confirmed dengue cases have been reported in Zhejiang Province. The emergence of insecticide resistance in mosquitoes will affect the control of dengue. Our study aims to investigate the current situation of insecticide resistance of Ae. Read More

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http://dx.doi.org/10.5582/bst.2020.03194DOI Listing

Exploration and correlation analysis of changes in Krebs von den Lungen-6 levels in COVID-19 patients with different types in China.

Biosci Trends 2020 Jun 21. Epub 2020 Jun 21.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

This study aimed to determine the clinical significance of Krebs von den Lungen-6 (KL-6) in patients with COVID-19, so as to find a marker with high sensitivity, specificity and easy detection to evaluate the lung injury and inflammation of COVID-19. Sixty-three COVID-19 patients and 43 non-COVID-19 patients with similar clinical phenotypes and/or imaging findings were enrolled to test the levels of KL-6 using chemiluminescent immunoassay. In addition, the blood gas, imaging and lymphocyte factors tests were collected from all participants. Read More

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http://dx.doi.org/10.5582/bst.2020.03197DOI Listing

Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma.

Biosci Trends 2020 Jun 14. Epub 2020 Jun 14.

Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.

Our purpose was to evaluate the correlation between endoplasmic reticulum ribosomal binding protein 1 (RRBP1) expression in cervical squamous cell carcinoma (CSCC) and poor patient prognosis. RRBP1 is a nascent transporter that is situated on the rough endoplasmic reticulum (ER). It adjusts to the secretion of proteins in cells and alleviates ER stress, thus stimulating cell proliferation. Read More

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http://dx.doi.org/10.5582/bst.2020.03136DOI Listing

Potential for jaktinib hydrochloride to treat cytokine storms in patients with COVID-19.

Biosci Trends 2020 Jun 12. Epub 2020 Jun 12.

Department of Infection and Imuunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a serious public health threat to the whole world, and the number of infected is still rising dramatically at this moment. Several studies have confirmed that cytokine storms play a critical role in causing a case to worsen from mild to severe or critical. The current treatment for cytokine storms is limited, so the international medical community is focusing on a specific and effective remedy. Read More

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http://dx.doi.org/10.5582/bst.2020.03106DOI Listing

High C-reactive protein/albumin ratio associated with reduced survival due to advanced stage of intrahepatic cholangiocarcinoma.

Biosci Trends 2020 Jun 5. Epub 2020 Jun 5.

Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.

C-reactive protein (CRP)- and albumin (Alb)-based scoring systems are available for predicting the prognosis of patients with diverse forms of gastrointestinal cancer, but their utility for patients with intrahepatic cholangiocarcinoma (ICC) is still unclear. This study aimed to elucidate whether a high CRP/Alb ratio is associated with the surgical outcome of ICC patients. Patients who underwent initial and curative resection for ICC were included in this study, and were divided into the High and Low CRP/Alb groups based on their preoperative CRP and Alb values. Read More

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http://dx.doi.org/10.5582/bst.2020.03167DOI Listing

The cytotoxicity of advanced glycation end products was attenuated by UCMSCs in human vaginal wall fibroblasts by inhibition of an inflammatory response and activation of PI3K/AKT/PTEN.

Biosci Trends 2020 Jun 3. Epub 2020 Jun 3.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Pelvic organ prolapse (POP) occurs when the pelvic organs (bladder, bowel or uterus) herniate into the vagina, causing incontinence, voiding, and bowel and sexual dysfunction, negatively impacting upon a woman's quality of life. Intermediate intermolecular cross-links and advanced glycation cross-links increase in prolapsed tissue. Stem cells are able to participate in tissue repair due to their ability to differentiate into multiple lineages, and thus into various types of connective tissue cells, so they therefore hold great promise for treating pelvic floor dysfunction. Read More

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http://dx.doi.org/10.5582/bst.2020.03125DOI Listing

Predicting intervention effect for COVID-19 in Japan: state space modeling approach.

Biosci Trends 2020 May 28. Epub 2020 May 28.

Nospare Inc. Tokyo, Japan.

Japan has observed a surge in the number of confirmed cases of the coronavirus disease (COVID-19) that has caused a serious impact on the society especially after the declaration of the state of emergency on April 7, 2020. This study analyzes the real time data from March 1 to April 22, 2020 by adopting a sophisticated statistical modeling based on the state space model combined with the well-known susceptible-infected-recovered (SIR) model. The model estimation and forecasting are conducted using the Bayesian methodology. Read More

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http://dx.doi.org/10.5582/bst.2020.03133DOI Listing

Does immune privilege result in recovered patients testing positive for COVID-19 again?

Authors:
Jufeng Xia

Biosci Trends 2020 May 16. Epub 2020 May 16.

Graduate School of Frontier Science, The University of Tokyo, Tokyo, Japan.

Recently, an increasing number of reports have indicated that a few patients who were believed to have recovered from COVID-19 initially tested negative but later tested positive. Several hospitals in different countries have detected SARS-CoV-2 RNA in the semen and cerebrospinal fluid of patients with severe COVID-19. Given the fact that the testes and central nervous system are both immune privilege sites and the fact that Ebola virus and Zika virus can avoid immune clearance and continue proliferating and spreading by hiding in those sites, the question of whether SARS-CoV-2 is present in immune privilege sites, it attacks those sites, and it spreads again after proliferating in those sites needs to be investigated. Read More

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http://dx.doi.org/10.5582/bst.2020.03154DOI Listing

The impact of social capital on civil society organizations delivering voluntary counseling and testing HIV/AIDS service: a cross-sectional study in China.

Biosci Trends 2020 May 16. Epub 2020 May 16.

School of Health Services Management, Anhui Medical University, Hefei, Anhui, China.

In China, Voluntary HIV Counseling and Testing (VCT) services are mostly provided by Civil Society Organizations (CSOs). This cross-sectional study investigated the association between CSOs' social capital and VCT service availability in eight Chinese provinces during July-December 2015. Data on CSOs' characteristics were collected through questionnaire-based interviews. Read More

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http://dx.doi.org/10.5582/bst.2020.03110DOI Listing

A breathing movement sensor for chest radiography during inspiration in children aged less than 3 years: a prospective randomized controlled study.

Biosci Trends 2020 May 17. Epub 2020 May 17.

Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan.

Chest radiographs should be obtained at the peak of inspiration so that radiological findings can be precisely interpreted. However, this is not easily achieved, particularly in young children who do not follow the instruction to hold their breath. We developed a sensor that detects the breathing movements and conducted a randomized controlled study to determine whether the sensor would increase the proportion of chest radiographs obtained in the inspiration phase. Read More

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http://dx.doi.org/10.5582/bst.2020.03024DOI Listing

Introduction on collective quarantine of close contacts of patients with COVID-19 for medical observation in China: from the perspective of frontline staff.

Biosci Trends 2020 May 9. Epub 2020 May 9.

Malu Community Health Service Center, Jiading District, Shanghai, China.

The World Health Organization (WHO) has deemed coronavirus disease 2019 (COVID-19) to be a pandemic. The strict prevention and control measures taken by China have proven to be effective, creating a window of opportunity for other countries. The tracking and management of contacts of patients with COVID-19 are important components of prevention and control measures. Read More

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http://dx.doi.org/10.5582/bst.2020.03094DOI Listing

An international comparison analysis of reserve and supply system for emergency medical supplies between China, the United States, Australia, and Canada.

Biosci Trends 2020 May 9. Epub 2020 May 9.

Department of Health Policy Research, Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai, China.

Coronavirus disease 19 (COVID-19) has become a pandemic around the world. With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. Taking China, the United States, Australia, and Canada as examples, this study compares and analyzes the reserve and supply systems of emergency medical supplies and problems exposed in response to the COVID-19 epidemic. Read More

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http://dx.doi.org/10.5582/bst.2020.03093DOI Listing

Current status of laparoscopic radical hilar cholangiocarcinoma in Mainland China.

Biosci Trends 2020 May 9. Epub 2020 May 9.

Division of Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Our purpose was to explore the status of laparoscopic radical resection of hilar cholangiocarcinoma (LRRHcca) in Mainland China. Studies published before February 2020 were retrieved from CNKI database, Pubmed database and Wanfang database. Search terms included "hilar cholangiocarcinoma", "Klatskin tumor", "laparoscopy", "radical operation". Read More

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http://dx.doi.org/10.5582/bst.2020.03010DOI Listing

Design, synthesis, and biological evaluation of 4-phenoxybenzenesulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.

Biosci Trends 2020 May 9. Epub 2020 May 9.

Department of Medical Chemistry, School of Pharmacy, Weifang Medical University, Weifang, Shandong, China.

A series of 4-phenoxybenzenesulfonyl pyrrolidine derivatives were designed, synthesized, and evaluated as matrix metalloproteinases (MMPs) inhibitors. All of the synthesized compounds displayed inhibitory activity against MMP-2 and MMP-9. Compounds 4a, 4e, and 4i displayed more potent activity than the other compounds. Read More

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http://dx.doi.org/10.5582/bst.2020.01051DOI Listing
May 2020
1.663 Impact Factor

Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China.

Biosci Trends 2020 Apr 30. Epub 2020 Apr 30.

Department of Severe hepatopathy, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

To investigate the characteristic of coagulation function in 303 patients with Coronavirus disease 2019 (COVID-19), we evaluated the correlation between coagulation function and disease status. We retrospectively analyzed 303 patients diagnosed with COVID-19 and evaluated the clinical data of 240 patients who were discharged. The coagulation function of the two groups (mild and severe) was compared. Read More

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http://dx.doi.org/10.5582/bst.2020.03086DOI Listing

Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.

Biosci Trends 2020 Apr 30. Epub 2020 Apr 30.

Isotope Science Center, The University of Tokyo, Tokyo, Japan.

Salmonella enterica serovar Typhimurium (Salmonella), a pathogenic bacterium, is a major cause of foodborne diseases worldwide. Salmonella injects multiple virulence factors, called effectors, into cells and causes multiple rearrangements of cellular biological reactions that are important for Salmonella proliferation and virulence. Previously, we reported that Salmonella infection causes loss of MTR4 and RRP6, which are nuclear RNA degradation factors, resulting in the stabilization and accumulation of unstable nuclear RNAs. Read More

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http://dx.doi.org/10.5582/bst.2020.03085DOI Listing

Suggestions on surgical treatment during coronavirus disease 2019 (COVID-19) pandemic.

Biosci Trends 2020 Apr 27. Epub 2020 Apr 27.

The Second Department of Hepatopancreatobiliary Surgery, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 virus, is now generating a global epidemic, leading to a severe public health emergency. Until April 12, 2020 around 1,700,954 confirmed cases and 105,633 deaths have been reported all over the world. The World Health Organization (WHO) has declared COVID-19 as a Public Health Emergency of International Concern. Read More

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http://dx.doi.org/10.5582/bst.2020.03098DOI Listing

Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database.

Biosci Trends 2020 May 22;14(2):139-143. Epub 2020 Apr 22.

Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

In late March and early April 2020, the antimalarial drug, chloroquine, has been approved as an emergency treatment for the coronavirus disease 2019 (COVID-19) in the United States and in Europe. Although infrequent, neuropsychiatric symptoms have been reported in patients who received chloroquine for the treatment of malaria or autoimmune diseases. In this study, aiming to investigate these adverse events (AEs) using a large self-reporting database, we conducted a disproportionality analysis for the detection of neuropsychiatric AE signals associated with the use of chloroquine (or hydroxychloroquine), reported to FDA Adverse Event Reporting System (FAERS) database between the fourth quarter of 2012 and the fourth quarter of 2019. Read More

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http://dx.doi.org/10.5582/bst.2020.03082DOI Listing

Asymptomatic carriers of COVID-19 as a concern for disease prevention and control: more testing, more follow-up.

Biosci Trends 2020 Apr 22. Epub 2020 Apr 22.

School of Public Health, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, China.

Following a containment phase of two months, China has transitioned to the mitigation phase. However, China still faces the risk of COVID-19 spreading due to not only to sporadic new cases and imported cases but also asymptomatic carriers. According to daily reports from the National Health Commission of the People's Republic of China from March 31, 2020 to April 7, 2020, the number of new asymptomatic cases reported daily greatly exceeded that of new imported cases. Read More

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http://dx.doi.org/10.5582/bst.2020.03069DOI Listing

A practice of anesthesia scenario design for emergency cesarean section in patients with COVID-19 infection based on the role of standard patient.

Biosci Trends 2020 Apr 22. Epub 2020 Apr 22.

Department of Anesthesiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

The new coronavirus (COVID-19) has been characterized as a world pandemic by WHO since March 11, 2020. Although it is likely that COVID-19 transmission is primarily via droplets and close contact, airborne transmission and fecal-oral route remains a possibility. The medical staff working in the operating room, such as anesthesiologists, surgeons and nurses, are at high risk of exposure to virus due to closely contacting patients. Read More

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http://dx.doi.org/10.5582/bst.2020.03066DOI Listing

Comparative transcriptome analysis of transcultured human skin-derived precursors (tSKPs) from adherent monolayer culture system and tSKPs-derived fibroblasts (tFBs) by RNA-Seq.

Biosci Trends 2020 May 23;14(2):104-114. Epub 2020 Apr 23.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Transcultured human skin derived precursors (tSKPs) from adherent monolayer culture system have similar characteristics as traditional skin derived precursors (SKPs), making tSKPs a suitable candidate for regenerative medicine. tSKPs can differentiate into fibroblasts. However, little is known about the molecular mechanism of the transition from tSKPs to fibroblasts. Read More

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http://dx.doi.org/10.5582/bst.2019.01345DOI Listing
May 2020
1.663 Impact Factor

Identification and characterization of the V3 promoter of the ST3GAL4 gene.

Biosci Trends 2020 May 15;14(2):144-150. Epub 2020 Apr 15.

Instituto Mexicano del Seguro Social, Centro de Investigación Biomédica de Oriente, Laboratorio de Biología Molecular, Metepec, Puebla, Mexico.

The ST3GAL4 gene encodes the enzyme Galβ1-4GlcNAc α2,3 sialyltransferase (ST3Gal IV). This enzyme participates in the synthesis of the sialyl Lewis x antigen. In different cancer types altered expression of this antigen has been reported. Read More

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http://dx.doi.org/10.5582/bst.2019.01331DOI Listing

NEK7: a potential therapy target for NLRP3-related diseases.

Biosci Trends 2020 May 16;14(2):74-82. Epub 2020 Apr 16.

Department of Geriatrics Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

NLRP3 inflammasome plays an essential role in innate immunity, yet the activation mechanism of NLRP3 inflammasome is not clear. In human or animal models, inappropriate NLRP3 inflammasome activation is implicated in many NLRP3-related diseases, such as tumors, inflammatory diseases and autoimmune diseases. Until now, a great number of inhibitors have been used to disturb the related signaling pathways, such as IL-1β blockade, IL-18 blockade and caspase-1 inhibitors. Read More

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http://dx.doi.org/10.5582/bst.2020.01029DOI Listing

Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19).

Biosci Trends 2020 May 13;14(2):156-158. Epub 2020 Apr 13.

Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao, China.

Drugs that are specifically efficacious against SARS-CoV-2 have yet to be established. Chloroquine and hydroxychloroquine have garnered considerable attention for their potential to treat coronavirus disease 2019 (COVID-19). Increasing evidence obtained from completed clinical studies indicates the prospects for chloroquine/hydroxychloroquine to treat COVID-19. Read More

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http://dx.doi.org/10.5582/bst.2020.03072DOI Listing

Macrolide treatment for COVID-19: Will this be the way forward?

Biosci Trends 2020 May 5;14(2):159-160. Epub 2020 Apr 5.

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. Using structure-based drug selection for identification of SARS-CoV-2 protease inhibitors, old drugs such as macrolides (MAC) were predicted to be effective for COVID-19. Read More

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http://dx.doi.org/10.5582/bst.2020.03058DOI Listing

Mobile field hospitals, an effective way of dealing with COVID-19 in China: sharing our experience.

Biosci Trends 2020 Apr 1. Epub 2020 Apr 1.

Hepatobiliary Surgery, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.

During the COVID-19 outbreak, China made great progress in controlling the epidemic, and the number of confirmed and suspected cases continues to decrease thanks to the various efforts employed. Mobile field hospitals have played a huge role in the centralized management of patients and they have effectively reduced transmission. This article describes some of our experiences operating mobile field hospitals in order to provide a reference and to better inform countries that are dealing with this crisis. Read More

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http://dx.doi.org/10.5582/bst.2020.01110DOI Listing

Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.

Biosci Trends 2020 May 1;14(2):115-122. Epub 2020 Apr 1.

School of Kinesiology, Shanghai University of Sport, Shanghai, China.

Dimethylarginine dimethylaminohydrolase-1 (DDAH1) maintains nitric oxide (NO) bioavailability by degrading asymmetric dimethylarginine (ADMA), which is an endogenous inhibitor of nitric oxide synthase (NOS). It has been well established that DDAH1 and exercise play crucial roles in promoting cardiac angiogenesis under pathological conditions. However, the role of DDAH1 in exercise-induced cardiac angiogenesis remains unclear. Read More

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http://dx.doi.org/10.5582/bst.2019.01351DOI Listing

Corrigendum.

Authors:

Biosci Trends 2020 ;14(1):E1

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http://dx.doi.org/10.5582/bst.2020.E1DOI Listing
January 2020

Health care reform in China from the perspective of physicians.

Biosci Trends 2020 May 27;14(2):151-155. Epub 2020 Mar 27.

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.

Health care reform is a worldwide problem. To address the problems of costs, access, quality, efficiency, and equity, China initiated healthcare reform in 2009. The progress of China's healthcare reform has been internationally recognized as the reform has expanded insurance coverage and improved access to and reduced the costs of care over the ten-year period from 2008 to 2018. Read More

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http://dx.doi.org/10.5582/bst.2020.01015DOI Listing

Analysis of COVID-19 infection spread in Japan based on stochastic transition model.

Biosci Trends 2020 May 19;14(2):134-138. Epub 2020 Mar 19.

International Health Care Center, National Center for Global Health and Medicine, Tokyo, Japan.

To assess the effectiveness of response strategies of avoiding large gatherings or crowded areas and to predict the spread of COVID-19 infections in Japan, we developed a stochastic transmission model by extending the Susceptible-Infected-Removed (SIR) epidemiological model with an additional modeling of the individual action on whether to stay away from the crowded areas. The population were divided into three compartments: Susceptible, Infected, Removed. Susceptible transitions to Infected every hour with a probability determined by the ratio of Infected and the congestion of area. Read More

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http://dx.doi.org/10.5582/bst.2020.01482DOI Listing

Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway.

Biosci Trends 2020 May 13;14(2):96-103. Epub 2020 Mar 13.

Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.

4-anilinoquinazoline-containing inhibitors of the epidermal growth factor receptor (EGFR) are widely used in non-small cell lung cancer patients with mutated EGFR, but they are less effective in multiple myeloma (MM), a fatal malignancy derived from plasma cells. The present study designed a series of novel compounds by conjugating a peroxide bridge to the 4-anilinoquinazoline pharmacophore. Further studies showed that these agents such as 4061 and 4065B displayed potent activity to induce MM cell apoptosis by upregulating pro-apoptotic p53 and Bax while downregulating pro-survival Bcl-2. Read More

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http://dx.doi.org/10.5582/bst.2019.01302DOI Listing

A steroidal saponin form Paris vietnamensis (Takht.) reverses temozolomide resistance in glioblastoma cells via inducing apoptosis through ROS/PI3K/Akt pathway.

Biosci Trends 2020 May 14;14(2):123-133. Epub 2020 Mar 14.

Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an, China.

Glioblastoma is one of the most difficult cancers to treat with a 5-year overall survival rate less than 5%. Temozolomide (TMZ) is an effective drug for prolonging the overall survival time of patients, while drug-resistance is an important clinical problem at present. Pennogenin-3-α-L-rhamnopyranosyl-(1→4)-[α-Lrhamno-pyranosyl-(1→2)]- β-D-glucopyranoside (N45), a steroidal saponin, was isolated from the rhizomes of Paris vietnamensis (Takht. Read More

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http://dx.doi.org/10.5582/bst.2020.01005DOI Listing

Overexpression of DJ-1 enhances colorectal cancer cell proliferation through the cyclin-D1/MDM2-p53 signaling pathway.

Biosci Trends 2020 May 4;14(2):83-95. Epub 2020 Mar 4.

The Second Affiliated Hospital Nanchang University, Nanchang University, Nanchang, Jiangxi, China.

Emerging evidence indicates that DJ-1 is highly expressed in different cancers. It modulates cancer progression, including cell proliferation, cell apoptosis, invasion, and metastasis. However, its role in colorectal cancer (CRC) remains poorly defined. Read More

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http://dx.doi.org/10.5582/bst.2019.01272DOI Listing

COVID-19: Real-time dissemination of scientific information to fight a public health emergency of international concern.

Biosci Trends 2020 Mar 25;14(1):1-2. Epub 2020 Feb 25.

International Health Care Center, National Center for Global Health and Medicine, Tokyo, Japan.

Rapidly sharing scientific information is an effective way to reduce public panic about COVID-19, and doing so is the key to providing real-time guidance to epidemiologists working to contain the outbreak, clinicians managing patients, and modelers helping to understand future developments and the possible effectiveness of various interventions. This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. As an academic journal, we will continue to quickly and transparently share data with frontline healthcare workers who need to know the epidemiological and clinical features of COVID-19. Read More

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http://dx.doi.org/10.5582/bst.2020.01056DOI Listing

Effects of different mark-up drug policies on drug-related expenditures in tertiary public hospitals: an interrupted time series study in Shanghai, China, 2015-2018.

Biosci Trends 2020 Mar 25;14(1):16-22. Epub 2020 Feb 25.

Key Lab of Health Technology Assessment, National Health Commission, School of Public Health, Fudan University, Shanghai, China.

Irrational use of drugs remains a major challenge especially in developing countries, which contributed to a heavy pharmaceutical expenditure burden. Price regulation has been taken to curb the growth of pharmaceutical expenditures in many countries. This study aimed to investigate the impact of different mark-up drug policies on drug-related expenditures in tertiary public hospitals in Shanghai, China. Read More

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http://dx.doi.org/10.5582/bst.2019.01350DOI Listing

Technical details of and prognosis for the "China stitch", a novel technique for totally laparoscopic hand-sewn esophagojejunostomy.

Biosci Trends 2020 Mar 25;14(1):56-63. Epub 2020 Feb 25.

Oncology Surgery Department, Beijing Shijitan Hospital, Capital Medical University (Peking University Ninth School of Clinical Medicine), Beijing, China.

The current study describes the technical details of and the clinical prognosis for the "China stitch", a novel technique for hand-sewn esophagojejunostomy in totally laparoscopic total gastrectomy. This study also explores the feasibility and safety of the technique. Clinical data of 20 patients with esophagogastric junction cancer in Beijing Shijitan Hospital, Capital Medical University from January 2017 to April 2018 were retrospectively analyzed. Read More

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http://dx.doi.org/10.5582/bst.2019.01329DOI Listing

Suppression of tumor growth and metastasis by ethanol extract of Angelica dahurica Radix in murine melanoma B16F10 cells.

Biosci Trends 2020 Mar 25;14(1):23-34. Epub 2020 Feb 25.

Anti-Aging Research Center, Dong-eui University, Busan, Korea.

The roots of Angelica dahurica have long been used as a traditional medicine in Korea to treat various diseases such as toothache and cold. In this study, we investigated the effect of ethanol extract from the roots of this plant on metastatic melanoma, a highly aggressive skin cancer, in B16F10 melanoma cells and B16F10 cell inoculated-C57BL/6 mice. Our results showed that the ethanol extracts of Angelicae dahuricae Radix (EEAD) suppressed cell growth and induced apoptotic cell death in B16F10 cells. Read More

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http://dx.doi.org/10.5582/bst.2019.01230DOI Listing

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

Biosci Trends 2020 Mar 19;14(1):72-73. Epub 2020 Feb 19.

Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, China.

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future. Read More

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http://dx.doi.org/10.5582/bst.2020.01047DOI Listing

Electrocardiographic abnormalities among people with HIV in Shanghai, China.

Biosci Trends 2020 Mar 20;14(1):9-15. Epub 2020 Feb 20.

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

People living with HIV (PLWH) have an excess risk of cardiovascular diseases (CVD). Electrocardiographic (ECG) abnormalities are independently predictive of incident cardiovascular events in the general population. Our study aimed to evaluate the prevalence and correlates of ECG abnormalities among PLWH in Shanghai, China. Read More

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http://dx.doi.org/10.5582/bst.2020.01013DOI Listing

Challenges to the system of reserve medical supplies for public health emergencies: reflections on the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in China.

Biosci Trends 2020 Mar 17;14(1):3-8. Epub 2020 Feb 17.

Department of Health Policy Research, Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai, China.

On December 31, 2019, the Wuhan Municipal Health Commission announced an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), China is now at a critical period in the control of the epidemic. The Chinese Government has been taking a series of rapid, comprehensive, and effective prevention and control measures. As the pandemic has developed, a fact has become apparent: there is a serious dearth of emergency medical supplies, and especially an extreme shortage of personal protective equipment such as masks and medical protective clothing. Read More

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http://dx.doi.org/10.5582/bst.2020.01043DOI Listing

Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment.

Biosci Trends 2020 Mar 9;14(1):64-68. Epub 2020 Feb 9.

Department of Respiratory Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. Read More

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http://dx.doi.org/10.5582/bst.2020.01030DOI Listing
March 2020
1.663 Impact Factor

Long-term outcomes of living donor liver transplantation in patients with a prior history of nonhepatic malignancy.

Biosci Trends 2020 Mar 5;14(1):42-47. Epub 2020 Feb 5.

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Posttransplant malignancy has become a significant cause of mortality. Data on the long-term outcomes of patients with pretransplant nonhepatic malignancy (PTM) after living donor liver transplantation (LDLT) are scarce, although the recipients of other organs with PTM have been reported to have a poor survival. Fifteen patients with PTM (4. Read More

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http://dx.doi.org/10.5582/bst.2019.01313DOI Listing

Neutrophil to lymphocyte ratio as a potential predictive marker for treatment with pembrolizumab as a second line treatment in patients with non-small cell lung cancer.

Biosci Trends 2020 Mar 4;14(1):48-55. Epub 2020 Feb 4.

Clinic of Medical Oncology, MHAT "Nadezhda", Sofia, Bulgaria.

The aim of this multicentric retrospective study is to evaluate the predictive and prognostic performance of neutrophil to lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and their dynamics in patients with non-small cell lung cancer (NSCLC) treated with pembrolizumab as a second line. Patients with metastatic NSCLC (n = 119), whose tumors expressed programmed death-ligand 1 (PD-L1) ≥ 1%, were retrospectively analyzed between Apr 2017 and Apr 2019. All patients received platinum-containing chemotherapy as a first line treatment. Read More

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http://dx.doi.org/10.5582/bst.2019.01279DOI Listing
March 2020
1.663 Impact Factor

Fast time perception is associated with high levels of anxiety in cancer patients prior to starting chemotherapy.

Biosci Trends 2020 Mar 6;14(1):35-41. Epub 2020 Feb 6.

Clinic of Medical Oncology, UMHAT "St. Marina", Varna, Bulgaria.

Our study explored the potential relationship between time perception and the level of anxiety in cancer patients prior to starting chemotherapy. Time perception was assessed in 162 chemonaïve patients with solid tumors by evaluating each subject's prospective estimation of how fast one minute passed compared to the actual amount of time passed. The median value of time perception was used to stratify the patients into two categories of fast and slow time perception. Read More

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http://dx.doi.org/10.5582/bst.2019.01296DOI Listing

Drug treatment options for the 2019-new coronavirus (2019-nCoV).

Authors:
Hongzhou Lu

Biosci Trends 2020 Mar 28;14(1):69-71. Epub 2020 Jan 28.

Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. Read More

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http://dx.doi.org/10.5582/bst.2020.01020DOI Listing

Male rats exhibit higher pro-BDNF, c-Fos and dendritic tree changes after chronic acoustic stress.

Biosci Trends 2019 ;13(6):546-555

Department of Neurosciences, Health Sciences University Centre, Guadalajara, Jalisco, Mexico.

Prolonged or intense exposure to environmental noise (EN) has been associated with a number of changes in auditory organs as well as other brain structures. Notably, males and females have shown different susceptibilities to acoustic damage as well as different responses to environmental stressors. Rodent models have evidence of sex-specific changes in brain structures involved in noise and sound processing. Read More

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http://dx.doi.org/10.5582/bst.2019.01288DOI Listing

The impact of apurinic-apyrimidinic endonuclease I on hepatocyte immuno-inflammatory factors and cell apoptosis.

Biosci Trends 2019 ;13(6):539-545

Oncology Surgery Department, Beijing Shijitan Hospital, Capital Medical University (Peking University Ninth School of Clinical Medicine), Beijing. China.

To explore the effect of apurinic-apyrimidinic endonuclease I (APE-1) on hepatocyte immune inflammatory factors and cell apoptosis. The gene expression profiles of peripheral blood of patients with or without immune tolerance after liver transplantation were obtained from the Gene Expression Omnibus (GEO). Differentially expressed genes were analyzed with a program in the R language, and the APE-1 gene was identified as a gene related to immune tolerance of liver transplantation. Read More

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http://dx.doi.org/10.5582/bst.2019.01316DOI Listing

Progress on drug pricing negotiations in China.

Biosci Trends 2020 Jan 26;13(6):464-468. Epub 2019 Dec 26.

Department of Health Policy Research, Shanghai Health Development Research Center (Shanghai Medical Information Center), Shanghai, China.

On November 28, 2019, the National Healthcare Security Administration (NHSA) and the Ministry of Human Resources and Social Security (MOHRSS) of China announced the results of drug pricing negotiations. Seventy first-negotiated drugs with 60.7% average price decrease and twenty-seven re-negotiated medicines with 26. Read More

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http://dx.doi.org/10.5582/bst.2019.01339DOI Listing
January 2020

PRKCH polymorphism is associated with rheumatoid arthritis in a Chinese population.

Biosci Trends 2020 Jan 26;13(6):556-561. Epub 2019 Dec 26.

Department of Rheumatology and Immunology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.

Genetic factors have been widely considered to have a substantial effect on the susceptibility to rheumatoid arthritis (RA). The purpose of this study was to determine whether the four newly discovered polymorphisms in a genome-wide association study (GWAS) meta-analysis confer susceptibility to RA in a Chinese Han population. We conducted a case-control study involving 359 RA cases and 873 age-and gender-matched controls and performed genotyping of four single nucleotide polymorphisms (SNPs), rs227163, rs726288, rs3783782 and rs2469434, using the dye terminator-based SNaPshot method. Read More

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http://dx.doi.org/10.5582/bst.2019.01247DOI Listing
January 2020

The state of minimally invasive pancreaticoduodenectomy in Chinese mainland: A systematic literature review.

Biosci Trends 2020 Jan 24;13(6):488-501. Epub 2019 Dec 24.

Division of Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

The development of Minimally invasive pancreaticoduodenectomy (MIPD) in Chinese mainland has been extremely quick. However, the safety and oncologic outcomes remain controversial. This review evaluates the current status of MIPD in Chinese mainland. Read More

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http://dx.doi.org/10.5582/bst.2019.01278DOI Listing
January 2020