4,582 results match your criteria Bioscience Reports[Journal]


Prognostic and immune regulating roles of YIF1B in Pan-Cancer: a potential target for both survival and therapy response evaluation.

Biosci Rep 2020 Jul 10. Epub 2020 Jul 10.

Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, China.

The neurotransmitter serotonin has emerged as a tumor growth factor and immune response regulator through complex signaling pathways. Yip1 Interacting Factor Homolog B (YIF1B) is a membrane protein involved in serotonin receptor membrane trafficking and signal transmission in neuropathy. Participation of YIF1B in serotonin-induced tumor growth and immune regulation has not been previously investigated. Read More

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http://dx.doi.org/10.1042/BSR20201384DOI Listing

Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies.

Biosci Rep 2020 Jul 10. Epub 2020 Jul 10.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.

Genetic polymorphisms for tuberculosis (TB) susceptibility has been researched by some studies, but few have studied multiple innate immunity genes associated with TB. Evidence suggests that the toll-like receptor 2, 4 (TLR2, TLR4) and toll interacting protein (TOLLIP) may be associated with TB susceptibility. In this self-validated study, we explored the association between common single nucleotide polymorphisms (SNPs) of TLR2, TLR4 and TOLLIP in the Chinese Han and Tibetan populations. Read More

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http://dx.doi.org/10.1042/BSR20193141DOI Listing

Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p.

Biosci Rep 2020 Jul 10. Epub 2020 Jul 10.

Zhongshan Hospital of Fudan University, Shanghai, China.

Increasing evidence shows that circular RNAs (circRNAs) play a regulatory role in cancer. In the present study, we aimed to investigate the characteristics and effects of hsa_circ_0026134 in hepatocellular carcinoma (HCC). We investigated hsa_circ_0026134 expression in 20 pairs of clinical tissues from HCC patients; expression of hsa_circ_0026134 in different cell lines; effect of hsa_circ_0026134 on proliferation and invasion of HCC cell lines; and the regulatory mechanisms and interactions among hsa_circ_0026134, miR-127-5p, tripartite motif-containing protein 25 (TRIM25) and insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3). Read More

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http://dx.doi.org/10.1042/BSR20191418DOI Listing

Variants and expression changes in PPAR-encoding genes presented no significant association with overall schizophrenia cases.

Biosci Rep 2020 Jul 9. Epub 2020 Jul 9.

First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China.

A few studies suggested the contribution of PPARs to the etiology of schizophrenia (SCZ). However, it is still not clear whether PPAR genes have a direct association with SCZ. The potential linkage between SCZ and the variants within PPAR encoding genes (PPARA, PPARD, and PPARG) was tested in a large cohort Genome-wide association study (GWAS) study. Read More

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http://dx.doi.org/10.1042/BSR20201083DOI Listing
July 2020
2.637 Impact Factor

Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer.

Biosci Rep 2020 Jul 8. Epub 2020 Jul 8.

West China Second Hospital, Chengdu, China.

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) in hormone metabolism pathways might cause metabolic disturbances and contribute to the development of polycystic ovary syndrome (PCOS) and ovarian cancer, but the published studies were inconsistent. The aim of this study was to evaluate the MTHFR C677T (rs1801133) and A1298C (rs1801131) gene polymorphisms in the risk of PCOS and ovarian cancer by meta-analysis. A comprehensive electronic search was conducted in databases for studies published from 1995 to 2020. Read More

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http://dx.doi.org/10.1042/BSR20200995DOI Listing

Net platelet clot strength of Thromboelastography platelet mapping assay for identification of high on treatment platelet reactivity in post-PCI patients.

Biosci Rep 2020 Jul 8. Epub 2020 Jul 8.

First Affiliated Hospital of China Medical University, Shenyang, China.

High on treatment platelet reactivity (HTPR) leads to more prevalence of thrombotic event in patients undergoing percutaneous coronary interventions (PCI). Dual antiplatelet therapy with aspirin in addition to one P2Y12 inhibitor is commonly administrated to reduce HTPR. However, "one size fits all" antiplatelet strategy is widely implemented due to lacking benefits with tailored strategy. Read More

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http://dx.doi.org/10.1042/BSR20201346DOI Listing

Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients.

Biosci Rep 2020 Jul 8. Epub 2020 Jul 8.

Xiangya Hospital Central South University, Changsha, China.

We enrolled 122 patients with glioma who received surgery treatment in our hospital from June 2010 to May 2012, and 60 healthy individuals. We found that the plasma miR-720 in the glioma group was significantly higher than that in the healthy control group (3.19±1. Read More

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http://dx.doi.org/10.1042/BSR20201449DOI Listing

Comments on "Association of FcepsilonRIbeta polymorphisms with risk of asthma and allergic rhinitis: evidence based on 29 case-control studies".

Biosci Rep 2020 Jul 8. Epub 2020 Jul 8.

Hubei University of Chinese Medicine, Wuhan, China.

Guo H. et al. (Bioscience reports (2018) 38, BSR20180177) published a meta-analysis concerning the association between 5 nucleotide polymorphisms (SNPs) in the high-affinity IgE receptor beta chain (FcεRIβ) gene, namely E237G, -109 C/T, RsaI_in2, RsaI_ex7, and I181L, and risk of asthma and allergic rhinitis based on available 29 case-control studies. Read More

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http://dx.doi.org/10.1042/BSR20193424DOI Listing

Novel prognostic prediction model constructed through machine learning on the basis of methylation-driven genes in kidney renal clear cell carcinoma.

Biosci Rep 2020 Jul 7. Epub 2020 Jul 7.

School of Computer Science and Technology, Xidian University, Xi'an, China.

Kidney renal clear cell carcinoma (KIRC) is a common tumor with poor prognosis and is closely related to many aberrant gene expressions. DNA methylation is an important epigenetic modification mechanism and a novel research target. Thus, exploring the relationship between methylation-driven genes and KIRC prognosis is important. Read More

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http://dx.doi.org/10.1042/BSR20201604DOI Listing

High lncSNHG15 expression may predict poor cancer prognosis: A meta-analysis based on the PRISMA and the Bio-informatics Analysis.

Biosci Rep 2020 Jul 7. Epub 2020 Jul 7.

The Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Background:  SNHG15 has been reported to be aberrantly expressed in various tumor tissues and could serve as a promising prognostic cancer biomarker. Previous studies on SNHG15 yielded inconsistent results with insufficient sampling. Here, a meta-analysis was conducted to investigate the prognostic value of SNHG15 in multiple cancers. Read More

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http://dx.doi.org/10.1042/BSR20194468DOI Listing

Concentrated Growth Factor inhibit UVA-induced photoaging in Human Dermal Fibroblasts via the MAPK/AP-1 pathway.

Biosci Rep 2020 Jul 6. Epub 2020 Jul 6.

Hebei Medical University, Shijiazhuang, China.

Ultraviolet (UV) radiation-induced photoaging is one of the contributors to skin aging. UV light triggers oxidative stress, producing a large number of matrix metalloproteinases and degrading the extracellular matrix in skin cells, thereby causing a series of photoaging symptoms. Concentrated growth factor (CGF) is a leukocyte- and platelet-rich fibrin biomaterial that plays a protective role in the occurrence and development of skin photoaging. Read More

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http://dx.doi.org/10.1042/BSR20193566DOI Listing

Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma.

Biosci Rep 2020 Jul 6. Epub 2020 Jul 6.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

As the most common neoplasm in digestive system, hepatocellular carcinoma (HCC) is one of the most important leading cause of cancer death worldwide. Its high-frequency metastasis and relapse rate lead to the poor survival of HCC patients. However, the mechanism of HCC metastasis is still unclear. Read More

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http://dx.doi.org/10.1042/BSR20201001DOI Listing

Association between vitamin D receptor BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk: an updated meta-analysis.

Biosci Rep 2020 Jul 6. Epub 2020 Jul 6.

Affiliated Heping Hospital, Changzhi Medical College, Changzhi, China.

Background: Many studies have reported the association between vitamin D receptor (VDR) polymorphism and osteoporosis risk. However, their results were conflicting. Six previous meta-analyses have been published to analyze VDR BsmI, FokI, and Cdx2 polymorphisms on osteoporosis risk. Read More

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http://dx.doi.org/10.1042/BSR20201200DOI Listing

Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats.

Biosci Rep 2020 Jul;40(7)

State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.

The present study was designed to investigate the anti-apoptosis effect of Ma xing shi gan decoction (MXD) on PM2.5-induced lung injury via protein kinase B (Akt)/mTOR/p70S6K pathway. A UPLC-MS/MS system was introduced for component analysis of MXD. Read More

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http://dx.doi.org/10.1042/BSR20193738DOI Listing

MiR-96-5p alleviates inflammatory responses by targeting NAMPT and regulating the NF-κB pathway in neonatal sepsis.

Biosci Rep 2020 Jul;40(7)

Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, Hubei, China.

Neonatal septicemia is a serious infectious disease in the neonatal period. MicroRNAs (miRNAs) have been reported to participate in the inflammatory responses in neonatal sepsis. The aim of the present study was to explore the effects and molecular mechanism of miR-96-5p on regulating the inflammatory responses in neonatal sepsis. Read More

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http://dx.doi.org/10.1042/BSR20201267DOI Listing

RNA-Sequencing and Bioinformatics Analysis of Long Noncoding RNAs and mRNAs in the asthenozoospermia.

Biosci Rep 2020 Jul 2. Epub 2020 Jul 2.

The First Affiliated Hospital of Hainan Medical University, Haikou, China.

Asthenozoospermia is one of the major causes of human male infertility. Long non-coding RNAs (lncRNAs) play critical roles in the spermatogenesis processes. This study aims to investigate the intricate regulatory network associated with asthenozoospermia. Read More

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http://dx.doi.org/10.1042/BSR20194041DOI Listing

A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens.

Biosci Rep 2020 Jul;40(7)

Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.

Dihydropyrimidine dehydrogenase (PydA) catalyzes the first step of the reductive pyrimidine degradation (Pyd) pathway in bacteria and eukaryotes, enabling pyrimidines to be utilized as substrates for growth. PydA homologs studied to date catalyze the reduction of uracil to dihydrouracil, coupled to the oxidation of NAD(P)H. Uracil reduction occurs at a flavin mononucleotide (FMN) site, and NAD(P)H oxidation occurs at a flavin adenine dinucleotide (FAD) site, with two ferredoxin domains thought to mediate inter-site electron transfer. Read More

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http://dx.doi.org/10.1042/BSR20201642DOI Listing

Meta-analysis of the relationship between methylenetetrahydrofolate reductase C677T and A1298C polymorphism and venous thromboembolism in the Caucasian and Asian.

Biosci Rep 2020 Jul;40(7)

The First Affiliated Hospital of Air Force Medical University (XiJing Hospital), Respiratory and Critical Care Medicine, Xi'an, Shaanxi 710032, P.R. China.

Recent years, it is a highly debated topic that whether methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and A1298C polymorphism could increase susceptibility to venous thromboembolism (VTE) in the Asian and Caucasian. Therefore, we expect to settle that controversy evidentially. Basic methods: Electronic databases (Pubmed, embase, Cochrane library, scopus, OvidSP, Wiley Online library, Springer link, EBSCO, Elsevier Science Direct, Google scholar) without date limitation were searched. Read More

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http://dx.doi.org/10.1042/BSR20200860DOI Listing

Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy.

Biosci Rep 2020 Jul;40(7)

Department of Clinical Laboratory Medicine, The University of Tokyo, Tokyo, Japan.

Background: Liver regeneration is an extremely complicated process that is regulated by a number of signaling pathways. Sphingosine 1-phosphate (S1P), a potent bioactive lipid mediator playing crucial roles in various cellular responses through its receptors, has been attracting attention in the fields of hepatology, where S1P lyase (SPL), an irreversibly degrading enzyme of S1P, reportedly has a stimulatory role in growth of hepatocellular carcinoma (HCC).

Aim Of The Study: To examine whether SPL might play a stimulatory role in liver regeneration. Read More

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http://dx.doi.org/10.1042/BSR20200592DOI Listing

Identification and validation of the phosphorylation sites on Aristaless-related homeobox (ARX).

Biosci Rep 2020 Jul 1. Epub 2020 Jul 1.

Xiamen University, Xiamen, China.

The Aristaless-related homeobox protein (ARX) is a transcription factor expressed in the developing forebrain, skeletal muscle, testis, and a variety of other tissues. It is known to have context-dependent transcriptional activator and repressor activity, although how it can achieve these opposing functions remains poorly understood. We hypothesized phosphorylation status might play a role in pivoting ARX between functioning as an activator or repressor. Read More

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http://dx.doi.org/10.1042/BSR20194513DOI Listing

Uterine fibroids may play a protecting role against endometrial carcinoma in Chinese women with gynecological diseases.

Biosci Rep 2020 Jul;40(7)

Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China.

Background: It has been reported that uterine fibroids (UFs) may increase the risk of endometrial carcinoma (EC) with the underlying mechanism largely unknown. Here, we explore whether UF could be an influential factor for EC.

Methods: We have collected and analyzed clinical data from 4537 Chinese patients to study the co-incidence of UF and EC. Read More

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http://dx.doi.org/10.1042/BSR20200350DOI Listing

Prognostic value of immune checkpoint molecules in breast cancer.

Biosci Rep 2020 Jul;40(7)

Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Zhejiang, Hangzhou 310022, People's Republic of China.

Immune checkpoint blockade treatments bring remarkable clinical benefits to fighting several solid malignancies. However, the efficacy of immune checkpoint blockade in breast cancer remains controversial. Several clinical trials of immune checkpoint blockades focused on the effect of CTLA4 and PD1/PDL1 checkpoint inhibitors on breast cancer. Read More

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http://dx.doi.org/10.1042/BSR20201054DOI Listing

Weighted gene co-expression network analysis to define pivotal modules and genes in diabetic heart failure.

Biosci Rep 2020 Jul;40(7)

Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Cancer Institute, Zhejiang University School of Medicine, Hangzhou, P. R. China.

This research was carried out to reveal specific hub genes involved in diabetic heart failure, as well as remarkable pathways that hub genes locate. The GSE26887 dataset from the GEO website was downloaded. The gene co-expression network was generated and central modules were analyzed to identify key genes using the WGCNA method. Read More

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http://dx.doi.org/10.1042/BSR20200507DOI Listing

Identification of feature autophagy-related genes in patients with acute myocardial infarction based on bioinformatics analyses.

Biosci Rep 2020 Jul;40(7)

Department of Structural Heart Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Objective: To identify feature autophagy-related genes (ARGs) in patients with acute myocardial infarction (AMI) and further investigate their value in the diagnosis of AMI.

Methods: Gene microarray expression data of AMI peripheral blood samples were downloaded from the GSE66360 dataset. The data were randomly classified into a discovery cohort (21 AMI patients and 22 healthy controls) and a validation cohort (28 AMI patients and 28 healthy controls). Read More

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http://dx.doi.org/10.1042/BSR20200790DOI Listing

Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer.

Biosci Rep 2020 Jul;40(7)

The Second Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.

Background: The minichromosome maintenance (MCM) family, a core component of DNA replication, is involved in cell cycle process. Abnormal proliferation has been identified as a crucial process in the evolution of colorectal cancer (CRC). However, the roles of the MCM family in CRC remain largely unknown. Read More

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http://dx.doi.org/10.1042/BSR20201503DOI Listing

Comprehensive analysis of the effect of rs2295080 and rs2536 polymorphisms within the mTOR gene on cancer risk.

Biosci Rep 2020 Jul;40(7)

Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China.

There is still no conclusion on the potential effect of the rs2295080 and rs2536 polymorphisms of mTOR (mammalian target of rapamycin) gene on different cancers. Herein, we performed a comprehensive assessment using pooled analysis, FPRP (false-positive report probability), TSA (trial sequential analysis), and eQTL (expression quantitative trait loci) analysis. Eighteen high-quality articles from China were enrolled. Read More

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http://dx.doi.org/10.1042/BSR20191825DOI Listing

miR-143-3p impacts on pulmonary inflammatory factors and cell apoptosis in mice with mycoplasmal pneumonia by regulating TLR4/MyD88/NF-κB pathway.

Biosci Rep 2020 Jul;40(7)

Department of Pediatric Respiratory Medicine, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu Province, China.

miR-143-3p is correlated with inflammatory pain responses, such as hsa-miR-143-3p expression reduction in fibromyalgia. The present study aimed to explore the effects of miR-143-3p and Toll-like receptor (TLR) 4/myeloid differentiation factor 88 (MyD88)/NF-κB signaling pathway on pulmonary inflammatory factors levels and alveolar epithelial cell apoptosis in mycoplasmal pneumonia mice. Twenty mice were selected as normal group. Read More

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http://dx.doi.org/10.1042/BSR20193419DOI Listing

The association between adiponectin gene rs182052 polymorphism and cancer risk: a meta-analysis.

Biosci Rep 2020 Jun;40(6)

Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions.

Methods: The PubMed, Embase, and Web of Science databases were searched until July 11, 2019. Read More

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http://dx.doi.org/10.1042/BSR20192410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322108PMC

RASA1 inhibits the progression of renal cell carcinoma by decreasing the expression of miR-223-3p and promoting the expression of FBXW7.

Biosci Rep 2020 Jul;40(7)

Cancer Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

RAS p21 protein activator 1 (RASA1), also known as p120-RasGAP, is a RasGAP protein that functions as a signaling scaffold protein, regulating pivotal signal cascades. However, its biological mechanism in renal cell carcinoma (RCC) remains unknown. In the present study, RASA1, F-box/WD repeat-containing protein 7 (FBXW7), and miR-223-3p expression were assessed via quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blot. Read More

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http://dx.doi.org/10.1042/BSR20194143DOI Listing