3,558 results match your criteria Bioscience Reports[Journal]


Circular RNAs in Gynecological Disease: promising biomarkers and diagnostic targets.

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Yongchuan Hospital of Chongqing Medical University, Chongqing, China

Circular RNAs (circRNAs) are a category of RNA molecules with covalently closed circles lacking both a 5' cap and a 3' tail. In recent years, circRNAs have attracted much attention and become a research hotspot of the RNA field following miRNAs and lncRNAs. CircRNAs exhibit tissue specificity, structural stability and evolutionary conservation. Read More

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http://dx.doi.org/10.1042/BSR20181641DOI Listing

Epigallocatechin-3-gallate inhibits doxorubicin-induced inflammation on human ovarian tissue.

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Gynecology and Physiopathology of Human Reproduction Unit, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital of Bologna, Italy, Bologna, 40138, Italy.

Chemotherapy protocol can destroy the reproductive potential of young cancer patients. Doxorubicin (DOX) is a potent anthracycline commonly used in the treatment of numerous malignancies. The purpose of the study was to evaluate the ovarian toxicity of DOX via inflammation and the possible protective effect of the green tea polyphenol epigallocatechin-3-gallate (EGCG). Read More

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http://dx.doi.org/10.1042/BSR20181424DOI Listing

The roles of sirtuin 1 and its activator, resveratrol in osteoarthritis.

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Xiangya Hospital, Central South University, Changsha, China.

Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process results in changes to joint tissues that ultimately contribute to the development of OA. Articular chondrocytes exhibit an aging-related decline in their proliferative and synthetic capacity. Sirtuin 1 (SIRT 1), a longevity gene related to many diseases associated with aging, is a NAD+-dependent protein deacetylase and master metabolic regulator. Read More

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http://dx.doi.org/10.1042/BSR20190189DOI Listing

LncRNA NRON downregulates lncRNA snaR and inhibits cancer cell proliferation in triple negative breast cancer (TNBC).

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

The First Affiliated Hospital of Zhengzhou University, zhengzhou, China

NRON mediates the degradation of tat protein to participate in HIV-1 infection. Interesting, our study observed the downregulation of NRON in triple negative breast cancer (TNBC) tissues compared with paired adjacent healthy tissues. In contrast, lncRNA snaR was upregulated in TNBC tissues and was inversely correlated with NRON. Read More

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http://dx.doi.org/10.1042/BSR20190468DOI Listing

Association between genetic polymorphisms and osteonecrosis in steroid treatment populations: a detailed stratified and dose-response meta-analysis.

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Yuxi Municipal Hospital of TCM Yuxi, China.

Background Steroid treatment has become recognized as an important risk factor for avascular osteonecrosis of the femoral head. However, not all patients who receive long-term, high-dose steroids develop osteonecrosis, indicating that there are individual differences in occurrence.MethodsWe explored the relationship between polymorphisms and steroid-induced osteonecrosis of the femoral head (SONFH) incidence with variables. Read More

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http://dx.doi.org/10.1042/BSR20190024DOI Listing
April 2019
1 Read

DUXAP10 inhibition attenuates the proliferation and metastasis of hepatocellular carcinoma cells by regulation of the Wnt/β-catenin and PI3K/Akt signaling pathways.

Biosci Rep 2019 Apr 17. Epub 2019 Apr 17.

Shaanxi Proxincial People's Hospital, Xi'an, China

The long non-coding RNA DUXAP10 has been involved in the development, progression and metastasis in several human cancers, but its biological function and underlying mechanism in HCC still undetermined. The present study was proposed to explore the effect of DUXAP10 on the growth and metastasis of HCC cells and the potential mechanisms involved. The results showed that DUXAP10 is dramatically elevated in HCC tumor tissues and cell lines. Read More

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http://dx.doi.org/10.1042/BSR20181457DOI Listing

MiR-205 suppresses epithelial-mesenchymal transition and inhibits tumor growth of human glioma through downregulation of HOXD9.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Liaocheng People's Hospital of Shandong, Liaocheng, 252000, China

Epithelial-mesenchymal transition (EMT) plays a pivotal role in cancer progression. Hsa-miR-205 is considered one of the fundamental regulators of EMT. In this study, we found that miR-205 was downregulated in glioma tissues and human glioma cells U87 and U251. Read More

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http://dx.doi.org/10.1042/BSR20181989DOI Listing

Oleic acid ameliorates palmitic acid-induced ER stress and inflammation markers in naive and cerulein-treated exocrine pancreas cells.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Ariel University, Ariel University, Ariel, Illinois, 40700, Israel

Dietary fat overload (typical to obesity) increases the risk of pancreatic pathologies through mechanisms yet to be defined. We previously showed that saturated dietary fat induces pancreatic acinar lipotoxicity and cellular stress. The endoplasmic reticulum (ER) of exocrine pancreas cells is highly developed and thus predisposed to stress. Read More

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http://dx.doi.org/10.1042/BSR20190054DOI Listing

MPSSS impairs the immunosuppressive function of cancer-associated fibroblasts via the TLR4-NF-κB pathway.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

The polysaccharides MPSSS was extracted from and has been reported to effectively inhibit tumor growth and to eliminate the function of myeloid-derived immune suppressor cell-mediated T cell inhibition, thus improving the efficacy of cancer therapy. The exploration of how MPSSS affects the functions of CAFs (cancer associated fibroblasts) will provide a new perspective for understanding the antitumor effects of MPSSS. In this study, prostate CAFs were selected as target cells to study whether MPSSS affected cell proliferation and function. Read More

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http://dx.doi.org/10.1042/BSR20182171DOI Listing

SOX21-AS1 is associated with clinical stage and regulates cell proliferation in nephroblastoma.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Linyi Central Hospital, Linyi, China.

LncRNA SOX21 antisense RNA 1 (SOX21-AS1) dysregulated in many types of human cancer, and functioned as tumor suppressor or promoter depending on tumor types. However, there was no report about the role of SOX21-AS1 in nephroblastoma. In present study, we firstly found SOX21-AS1 expression was elevated in nephroblastoma tissues and cell lines compared with adjacent normal tissues and normal human embryonic kidney cell line, respectively. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20190602
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http://dx.doi.org/10.1042/BSR20190602DOI Listing
April 2019
1 Read

miR-26a prevents neural stem cells from apoptosis via β-catenin signaling pathway in cardiac arrest-induced brain damage.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

The First Affiliated Hospital of Zhongshan University, Guangzhou, Alaska, China

Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use of this kind of therapy. Read More

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http://dx.doi.org/10.1042/BSR20181635DOI Listing

Association between neutrophil-lymphocyte ratio and arterial stiffness in patients with acute coronary syndrome.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

the Second Xiangya Hospital of Central South University, Changsha, China.

The aim of this study was to assess the association between neutrophil-lymphocyte ratio (NLR) and arterial stiffness and provide a predictive index for diagnosing atherosclerosis in patients with acute coronary syndrome. We enrolled patients with acute coronary syndrome who were confirmed by coronary angiography. Data were collected by questionnaire and blood indexes. Read More

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http://dx.doi.org/10.1042/BSR20190015DOI Listing

NT5E is associated with unfavorable prognosis and regulates cell proliferation and motility in gastric cancer.

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

Qilu Hospital of Shandong University, Jinan, China.

Ecto-5'-nucleotidase (NT5E) is a glycosylphosphatidylinositol anchored cell surface protein, and has been suggested to be dysregulated in most types of human cancer including gastric cancer. The aim of this study was to present more evidence about the clinical and prognostic value of Ecto-5'-nucleotidase in gastric cancer patients, and preliminarily explore the biological function of Ecto-5'-nucleotidase in gastric cancer cells. In our study, high Ecto-5'-nucleotidase expression was observed in gastric cancer tissues and cell lines respectively compared to normal gastric mucosa tissues cells. Read More

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http://dx.doi.org/10.1042/BSR20190101DOI Listing

Green synthesis of silver nanoparticles using  and   extracts  in BALB/c mice infected with  .

Biosci Rep 2019 Apr 16. Epub 2019 Apr 16.

King Saud University, Riyadh, Egypt

Toxoplasmosis constitutes a global infection caused by oblige intracellular apicomplexan protozoan parasite. Although often asymptomatic, infection can result in more severe, potentially life threatening symptoms particularly in immunocompromised individuals. The present study evaluated the anti-Toxoplasma effects in experimental animals of silver nanoparticles synthesized in combination with extracts of natural plants ( and ) as an alternative method to standard sulfadiazine drug therapy. Read More

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http://dx.doi.org/10.1042/BSR20190379DOI Listing
April 2019
2 Reads

Functional study of the association of polymorphisms with asthma susceptibility in the Southwest Chinese Han population.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China, Chengdu, China

Background: Chitinase 3-like 1 ( ) is involved in the Th2 cell mediated pathway, tissue remodeling and fibrosis. Correlations of gene polymorphisms with asthma in previous studies have been inconsistent.This study was designed to investigate the association between polymorphisms and asthma in the southwest Chinese Han population. Read More

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http://dx.doi.org/10.1042/BSR20182008DOI Listing

Are SGLT2 polymorphisms linked to diabetes mellitus and cardiovascular disease? Prospective study and meta-analysis.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

VIVIT, Feldkirch, Arizona, Austria.

Inhibition of the sodium glucose co-transporter 2 (SGLT2) reduces cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) with atherosclerotic cardiovascular disease. So far, a link between common genetic variations of the SGLT2 encoding gene SLC5A2 and glucose homeostasis as well as cardiovascular disease has not been established. This study, therefore, aimed to investigate SLC5A2 SNPs in relation to type 2 diabetes and coronary artery disease (CAD) and prospectively the incidence of cardiovascular events. Read More

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http://dx.doi.org/10.1042/BSR20190299DOI Listing

Long non-coding RNA GEHT1 promoted the proliferation of ovarian cancer cells via modulating the protein stability of HIF1α.

Authors:
Dan Liu Hao Li

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Gynecology, The People`s Hospital of Hanchuan city, Hanchuan, China

Cancer cells preferentially metabolize glucose via the aerobic glycolysis pathway, which is also named as Warburg effect. Increasing evidence has suggested that suppression of glycolysis inhibits the progression of cancers. In this study, we found that the long non-coding RNA gastric carcinoma high expressed transcript 1 (GHET1) was overexpressed in ovarian cancer tissues and cell lines. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20181650
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http://dx.doi.org/10.1042/BSR20181650DOI Listing
April 2019
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Evaluation of the real-time fluorescence loop-mediated isothermal amplification assay for the detection of .

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, 63 Duobao Road,Liwan District, Guangzhou, Georgia, 510150, China

 is a major pathogenic bacterium causing perinatal infections in humans. In this study, a novel real-time fluorescence loop-mediated isothermal amplification technology was successfully developed and evaluated for the detection of  in a single reaction. Six specific primers were designed to amplify the corresponding six regions of fbs B gene of , using Bst DNA polymerase with DNA strand displacement activity at a constant temperature for 60 minutes. Read More

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http://dx.doi.org/10.1042/BSR20190383DOI Listing

Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, fuzhou, China

Circular RNAs (circRNAs) formed by back-splicing play multiple roles in the occurrence and development of cancer. Here, we found that hsa_circ_0004370 was upregulated in both esophageal cancer (EC) tissues and cell lines. Loss function of hsa_circ_0004370 by si-RNA significantly suppressed proliferation and invasion and promoted apoptosis in both EC cell lines. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182377
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http://dx.doi.org/10.1042/BSR20182377DOI Listing
April 2019
1 Read

A gene signature predict response to neoadjuvant chemotherapy in triple-negative breast cancer patients.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Cancer Hospital of Liaoning Province, Shenyang, China.

Triple-negative breast cancer (TNBC) accounts for about 15% of all breast cancer cases. TNBC is highly aggressive and associated with poor prognosis. This study aimed to compare gene expression between TNBC patients with pathological complete response (pCR) and those with not complete response (nCR) to neoadjuvant chemotherapy (NAC). Read More

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http://dx.doi.org/10.1042/BSR20190414DOI Listing

LncRNA-MALAT1 promotes neovascularization in diabetic retinopathy through regulating miR-125b/VE-cadherin axis.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

The Second Xiangya Hospital of Central South University, Changsha, 410008, China

Background:  Diabetic retinopathy (DR) is currently the leading cause of blindness and visual disability in adults with diabetes mellitus (DM). Neovascularization has been identified as an important clinical property in DR, however, the exact mechanisms in DR neovascularization are still unclear and need further elucidation.

Methods: qRT-PCR was conducted to detect the expression level of lncRNA-MALAT1, miR-125b and VE-cadherin in human retina microvascular endothelial cells (hRMECs) treated with high glucose (HG). Read More

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http://dx.doi.org/10.1042/BSR20181469DOI Listing

Clinical and pathological significance of Homo sapiens ceramide synthase 2(CerS-2) in diverse human cancers.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China

Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. Read More

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http://dx.doi.org/10.1042/BSR20181743DOI Listing

Genetic Diversity and Drug Susceptibility Patterns of the Complex in Yunnan, China.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Kunming Medical University, Kunming, China

Tuberculosis (TB) is a infectious disease caused by  (Mtb) which has been threatening global public health for many years. High genetic diversity is dominant feature of Mtb Increasing cases of Multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem to TB control in China. Spontaneous mutations in the Mtb genome can alter proteins which are the target of drugs, making the bacteria become drug resistant. Read More

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http://dx.doi.org/10.1042/BSR20181746DOI Listing

Hydroxyurea promotes TET1 expression and induces apoptosis in osteosarcoma cells.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Ten-eleven translocation (TET) proteins are abnormally expressed in various cancers. Osteosarcoma cells were treated with hydroxyurea to investigate the expression pattern of TET proteins in these cells. The expression of TET1 was increased in U2OS cells after treatment with hydroxyurea. Read More

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http://dx.doi.org/10.1042/BSR20190456DOI Listing

CircLMTK2 acts as a novel tumor suppressor in gastric cancer.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 of Dong'an Road, Shanghai, 200032, China

Recently, circRNAs have been found to play regulatory roles in cancer. In the present study, we aimed to investigate the characteristics and effect of circLMTK2 and its potential role as a novel biomarker in cases of gastric cancer (GC). 111 pairs of clinical tissues from patients were collected for circLMTK2 expression investigation. Read More

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http://dx.doi.org/10.1042/BSR20190363DOI Listing

miR-20a regulates sensitivity of colorectal cancer cells to NK cells by targeting MICA.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

This site is designed to facilitate the manuscript submission and peer review process. It collects Personally Identifiable Information ("PII") such as name, e-mail address, telephone number, postal address, organizational affiliation, areas of expertise, IP address, and system usage. This PII information is collected to secure the site, ensure that there are no conflicts-of-interest during the peer review process, address ethics violations, facilitate communications regarding manuscript submissions and peer reviews, and to track/report on submissions and system usage. Read More

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http://dx.doi.org/10.1042/BSR20180695DOI Listing

Notch signaling pathway regulates CD4CD25CD127 regulatory T cells and T helper 17 cells function in gastric cancer patients.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

The First Affiliated Hospital of Xinxiang Medical University, Weihui, China

Regulatory T cells (Tregs) and T helper 17 (Th17) cells contributes to cancer progression and prognosis. However, regulatory factors associated with Tregs-Th17 balance were not completely understood. We previously demonstrated an immune-modulatory capacity by Notch signaling inactivation to reverse Tregs-Th17 disequilibrium in chronic hepatitis C. Read More

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http://dx.doi.org/10.1042/BSR20182044DOI Listing

Associations between cytotoxic T-lymphocyte-associated antigen 4 gene polymorphisms and diabetes mellitus: a meta-analysis of 76 case-control studies.

Authors:
Min Chen ShuMin Li

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Ningbo No.6 Hospital, Ningbo, China

Background: Several genetic association studies already investigated potential roles of cytotoxic T-lymphocyte-associated antigen 4 ( ) gene polymorphisms in diabetes mellitus (DM), with inconsistent results. Therefore, we performed this meta-analysis to better assess the relationship between gene polymorphisms and DM in a larger pooled population.

Methods: PubMed, Embase, Web of Science and CNKI were systematically searched for eligible studies. Read More

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http://dx.doi.org/10.1042/BSR20190309DOI Listing

Strong association of tissue inhibitor of metalloproteinase (TIMP) -2 and -3 promoter SNPs with risk of CRC in Kashmiri population.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Basic Medical Sciences, King Saud Bin Abdulaziz University for Health Scineces, Jeddah, Jeddah, 21423, Saudi Arabia

The tissue inhibitors of metalloproteinases (TIMPs) including TIMP2 and TIMP3 are the key physiological inhibitors of matrix metalloproteinases (MMPs) and along with MMPs, TIMPs play a vital role in the coordinated proteolytic breakdown and remodeling of the extracellular matrix (ECM) and the basement membrane that represent the barriers to any malignant tumor invasion and progression. The aim of this study was to analyze the association of TIMP2-418G/C and TIMP3-1296T/C promoter SNPs with colorectal cancer (CRC) susceptibility and development risk and also to evaluate the modifying effects of possible TIMP2-418G/C and TIMP3-1296T/C SNPs'genotypes on different risk factors of CRC in ethnic population of Kashmir, India through a case-control setup. The genotype frequencies of TIMP2-418G/C and TIMP3-1296T/C promoter SNPs were compared between 142 CRC patients and 184 individually matched healthy controls by using PCR-RFLP method. Read More

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http://dx.doi.org/10.1042/BSR20190478DOI Listing

PDK-1 mediated Hippo-YAP-IRS2 signaling pathway and involved in the apoptosis of non-small cell lung cancer cells.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Respiratory Medicine, Yanan University Affiliated Hospital, No. 43 of North Street, Yan'an, 716000, China

Pyruvate dehydrogenase kinase-1 (PDK-1), a gatekeeper enzyme, was involved in cancer progression, such as tumor angiogenesis, cell survival and growth. Recent evidence indicated that PDK-1 may be involved in lung cancer, however, the function and underlying mechanism of PDK-1 is remaining unclear. In the present study, our aim was to investigate the role and mechanisms of PDK-1 in human non-small cell lung cancer (NSCLC) cells. Read More

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http://dx.doi.org/10.1042/BSR20182099DOI Listing

Microarray profiling of lung long non-coding RNAs and mRNAs in lipopolysaccharide-induced acute lung injury mouse model.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, NO.37, Guo Xue Xiang, Chengdu, 610041, China.

Long noncoding RNAs (LncRNAs) are involved in various biological processes as well as many respiratory diseases, while the role of lncRNAs in acute lung injury (ALI) remains unclear. The present study aimed to profile the expression of lung lncRNAs and mRNAs in lipopolysaccharide-induced ALI mouse model. C57BL/6 mice were exposed to lipopolysaccharide or phosphate buffered saline for 24 hours, and lncRNAs and mRNAs were profiled by Arraystar mouse LncRNA Array V3. Read More

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http://dx.doi.org/10.1042/BSR20181634DOI Listing

Mechanisms of natural resistance of Balb/c mice to experimental liver amoebiasis.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Unidad de Investigación en Medicina Experimental, Universidad Nacional Autónoma de México, Avenida Universidad 3000, México, 04510, Mexico

is the parasite responsible for human amoebiasis. The analysis of the natural resistance mechanisms of some rodents to amebic liver abscess (ALA) may reveal alternative pathogenicity mechanisms to those previously discovered in the experimental model of ALA in hamsters. In this work the natural resistance of BALB/c mice to ALA was explored by performing: 1) chemotaxis analysis with a specifically designed chamber; 2) amebic survival in fresh and decomplemented serum; 3) histological temporal course analysis of ALA development in mice with different treatments (hypocomplementemic, hyperimmune and treated with iNOS and NADPH oxidase inhibitors) and 4) mouse liver amebic infection by both implantation of ALA from hamsters and inoculation of parasites into the peritoneal cavity. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182333
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http://dx.doi.org/10.1042/BSR20182333DOI Listing
April 2019
1 Read

Association between epicardial adipose tissue and adverse outcomes in coronary heart disease patients with percutaneous coronary intervention.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China

We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue volume (EATV) was measured using multi-slice computed tomography. Read More

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http://dx.doi.org/10.1042/BSR20182278DOI Listing

Mesenchymal stem cells and their mitochondrial transfer: A double-edged sword.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Guangzhou Women and Children's Medical Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China

Mitochondrial dysfunction has been linked to many diseases including organ degeneration and cancer. Mesenchymal stem cells/stromal cells (MSCs) provide a valuable source for stem cell-based therapy and represent an emerging therapeutic approach for tissue regeneration. Increasing evidence suggests that MSCs can directly donate mitochondria to recover cell injury and rescue mitochondrial damage-provoked tissue degeneration. Read More

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http://dx.doi.org/10.1042/BSR20182417DOI Listing
April 2019
1 Read

Octamer binding transcription factor-4 expression is associated with cervical cancer malignancy and histological differentiation: A systematic review and meta-analysis.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Taihe Hospital, Shiyan, Washington, 442012, China

Objective: The relationship between the expression of octamer binding transcription factor 4  (OCT-4) and clinicopathological features of cervical cancer (CC) is evaluated in detail.

Methods: The findings on the relationship collected by retrieving PubMed, EMBASE, Cochrane library, Wan Fang and Chinese National Knowledge Infrastructure(CNKI) databases results and tracing back to the literature and published in public, which began in setting up the literature database and ended in May 2018. The literatures are screened, extracted and evaluated according to the inclusion and exclusion criteria, and meta-analysis was carried out via RevMan 5. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182328
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http://dx.doi.org/10.1042/BSR20182328DOI Listing
April 2019
1 Read

Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Oncology, Hubei Cancer Hospital, Wuhan, China

Background: Circular RNAs (circRNAs) have been reported as the competing endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) implicating in the initiation and progression of breast cancer. However, the functions of circRNAs in breast cancer have not been completely clarified. In the present study, we aimed to identify differentially expressed circRNAs in breast cancer tumor tissues, and their roles and downstream targets were investigated in the progression of breast cancer. Read More

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http://dx.doi.org/10.1042/BSR20181919DOI Listing

L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways.

Biosci Rep 2019 Apr 11. Epub 2019 Apr 11.

Ningbo Hospital of Zhejiang University, Ningbo, China.

The present study aims to evaluate the anticancer effect of L-securinine on androgen-independent prostate cancer (AIPC) DU145 cells. L-securinine (2.5 μM, 5 μM, and 10 μM) treatment for 24h, 48 and 72h displayed strong growth inhibitory effect on DU145 cells in a concentration and time-dependent fashion, but has less toxicity toward normal androgen-dependent LNCaP cells. Read More

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http://dx.doi.org/10.1042/BSR20190469DOI Listing
April 2019
2 Reads

MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR.

Biosci Rep 2019 Apr 11. Epub 2019 Apr 11.

Affiliated Hospital of Jining Medical University, Jining, China

Autism is a known as severe neurobehavioral syndrome, with males affected more often than females. Previous studies have revealed that microRNAs (miRNAs) play a critical role in the search for novel therapeutic strategies for autism. Therefore, we evaluate the ability of miR-153 to influence brain-derived neurotrophic factor (BDNF) of autism as well as proliferation and apoptosis of hippocampal neuron through the JAK-STAT signaling pathway by targeting leptin receptor (LEPR). Read More

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http://dx.doi.org/10.1042/BSR20181904DOI Listing

Novel Role of Snail 1 in Promoting Tumor Neoangiogenesis.

Biosci Rep 2019 Apr 11. Epub 2019 Apr 11.

The Chinese People's Liberation Army, Beijing, China.

Snail1 plays an important role in epithelial to mesenchymal transition (EMT) during tumor metastasis; however, whether Snai1 potentiates the process of neoangiogenesis is completely unknown. In this study, tube formation assay was used to evaluate neoangiogenesis in vitro. The expression of Snai1 and other pro-neoangiogenic factors was measured by qRT-PCR. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182161
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http://dx.doi.org/10.1042/BSR20182161DOI Listing
April 2019
1 Read

MicroRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targeting TLR4.

Biosci Rep 2019 Apr 11. Epub 2019 Apr 11.

The Third Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Changchun, 130033, China

Fibroblast-like synoviocytes (FLSs) play a crucial role in rheumatoid arthritis (RA) pathogenesis. While microRNA (miR)-506 has been implicated in the progression of multiple diseases, its role in RA remains to be explored. This study evaluated the function of miR-506 in the regulation of RA-FLSs. Read More

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http://dx.doi.org/10.1042/BSR20182500DOI Listing

Identification of a prognostic twenty-eight-genes expression signature for gastric cancer with lymphatic metastasis.

Biosci Rep 2019 Apr 10. Epub 2019 Apr 10.

Tianjin Medical University, Tianjin, China

Gastric cancer (GC) patients have high mortality due to late-stage diagnosis, which is closely associated with lymph node metastasis. Exploring the molecular mechanisms of lymphatic metastasis may inform the research into early diagnostics of GC. In this study, we obtained RNA-Seq data from TCGA and used Limma package to identify differentially expressed genes (DEGs) between lymphatic metastases and non-lymphatic metastases in GC tissues. Read More

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http://dx.doi.org/10.1042/BSR20182179DOI Listing

The enhanced immunological activity of  flower polysaccharide on Newcastle disease vaccine in chicken.

Biosci Rep 2019 Apr 10. Epub 2019 Apr 10.

Jiangsu Agri-animal Husbandry Vocational College, Taizhou, China.

The extracts of exhibit multiple pharmacological activities. In present study,  flower polysaccharides (PTFP) were extracted by water decoction and ethanol precipitation, and the immunologic modulations of PTFP against Newcastle disease (ND) vaccine was investigated in chickens. The results showed that in certain range of concentrations, PTFP treatment can dose-dependently enhance lymphocyte proliferation. Read More

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http://dx.doi.org/10.1042/BSR20190224DOI Listing

Topical therapeutic corneal and scleral tissue cross-linking (TXL) solutions: in vitro  formaldehyde release studies using cosmetic preservatives.

Biosci Rep 2019 Apr 10. Epub 2019 Apr 10.

Ophthalmology, Columbia University, 635 W 165th Street, Eye Institute Research Annex Room 715, New York, New York, 10032, United States

Our recent tissue cross-linking studies using formaldehyde releasers (FARs) suggest that corneal and scleral tissue strengthening may be possible without using ultraviolet irradiation or epithelial removal, two requirements for the photochemical method in widespread clinical use.  Thus, this study was carried out in order to better understand these potential therapeutic solutions by studying the effects of concentration, pH, buffer, time, and tissue reactivity on formaldehyde release of these FARs. Three FARs, sodium hydroxymethyl glycinate (SMG), 1,3-dimethylol-5,5-dimethylhydantoin (DMDM), and diazolidinyl urea (DAU) were studied using a chromotropic acid colorimetric FA assay. Read More

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http://dx.doi.org/10.1042/BSR20182392DOI Listing
April 2019
4 Reads

A novel method to investigate the effects of gene mutations at the cellular level using a dual expression lentiviral vector.

Biosci Rep 2019 Apr 10. Epub 2019 Apr 10.

Wuhan University of Science and Technology, Wuhan, China

One of the conventional methods to study effects of gene mutations is that gene mutants are transfected into mammalian cells, and the dominant effects of gene mutants in the cells are examined. However, the result obtained using this method is not always satisfactory due to the interference of endogenous expression. Whether there is a better method to investigate the effects of gene mutations in cells remains to be examined. Read More

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http://dx.doi.org/10.1042/BSR20182383DOI Listing

Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Rostock University Medical Center, Rostock, Germany.

We aimed to identify differences in cytokine/chemokine levels in the aqueous humor (AH) of primary open-angle glaucoma (POAG) patients who suffered from scarring, compared to POAG patients with no scarring after trabeculectomy surgery. Identification of differently expressed cytokines and chemokines may help to understand scarring and fibrotic processes following trabeculectomy, and to make predictions for the outcome of fistulating surgery in the future. Furthermore, the identification of cell signaling pathways involved in fibrosis offers the opportunity for a more specific antifibrotic therapy with reduced side effects, and an improvement in long-term surgical outcome. Read More

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http://dx.doi.org/10.1042/BSR20181894DOI Listing

The resistant effect of SIRT1 in oxidative stress-induced senescence of rat nucleus pulposus cell is regulated by Akt-FoxO1 pathway.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: The senescence of nucleus pulposus (NP) cells induced by oxidative stress is one of the important causes of intervertebral disc degeneration (IDD). Herein, we investigated the role and action mechanism of silent information regulator 1 (SIRT1) in oxidative stress-induced senescence of rat NP cell.

Methods: Premature senescence of rat NP cells was induced by sublethal concentration of hydrogen peroxide (100μM). Read More

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http://dx.doi.org/10.1042/BSR20190112DOI Listing

SNP rs2596542 in MICA is associated with risk of hepatocellular carcinoma: a meta-analysis.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China.

The association of major histocompatibility complex class I chain-related gene A ( ) single nucleotide polymorphism (SNP) rs2596542G>A and hepatocellular carcinoma (HCC) has been broadly studied, with inconsistent results. Therefore, we conducted the current meta-analysis to better elucidate the roles of SNP rs2596542G>A in HCC. Eligible articles were searched in PubMed, CNKI, Wanfang, Embase, VIP, Web of Science, and CBM databases up to November 2018. Read More

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http://dx.doi.org/10.1042/BSR20181400DOI Listing

Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Department of Traditional Chinese medicine, Huadong Hospital, Shanghai, 200040, China

Background: Colon cancer is a leading cause of cancer-related deaths worldwide. The epithelial-mesenchymal transition (EMT) plays an important role in tumor metastasis of colon cancer.

Methods: We firstly evaluated the effects of EMT related transcription factors on the prognosis of colon cancer through analysis the data obtained from The Cancer Genome Atlas (TCGA). Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20190452
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http://dx.doi.org/10.1042/BSR20190452DOI Listing
April 2019
1 Read

LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Ankang Central Hospital, Ankang, China

The dysregulated expression of LSINCT5 has been found in various human tumors, and was generally related to cancer progression and unfavorable prognosis. Although the role of LSINCT5 in osteosarcoma was reported not long ago, the sample size of of that study was limited. Our study presented more evidence about the clinical significance and biological function of LSINCT5 in osteosarcoma. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20190612
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http://dx.doi.org/10.1042/BSR20190612DOI Listing
April 2019
2 Reads

Epstein-Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Tianjin Cancer Hospital, Tianjin, China

The aim of this study was to evaluate the relationship of Epstein-Barr virus (EBV) infection and multiple myeloma (MM) and its impact on clinical characteristics and prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010 to May 2018 and 50 PBMCs samples from healthy donors were obtained. Polymerase chain reaction (PCR) was carried out for detection of EBV-DNA. Read More

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http://dx.doi.org/10.1042/BSR20190284DOI Listing
April 2019
1 Read
2.637 Impact Factor