2,123 results match your criteria Biorheology[Journal]


Endothelial barrier reinforcement relies on flow-regulated glycocalyx, a potential therapeutic target.

Biorheology 2019 Mar 29. Epub 2019 Mar 29.

Department of Bioengineering, Northeastern University, Boston, MA, USA.

Background: The onset of many disease processes depends on the function of the endothelial cell (EC) glycocalyx (GCX) which acts as a flow-dependent barrier to cellular infiltration and molecular transport across the blood vessel wall.

Objective: This review aims to examine these processes with the potential end goal of implementing GCX repair to restore EC barrier function and slow the progression of disease.

Methods: Cell and mouse studies were employed to examine the state of EC GCX in healthy versus disruptive flow conditions. Read More

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http://dx.doi.org/10.3233/BIR-180205DOI Listing

Blood flow distribution and the endothelial surface layer in the diabetic retina.

Biorheology 2019 Apr 1. Epub 2019 Apr 1.

Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

Diabetic retinopathy is known as a microvascular complication of hyperglycemia, with a breakdown of the blood-retinal barrier, loss of pericytes, formation of microhemorrhages, early decreases in perfusion and areas of ischemia, with the latter speculated to induce the eventual proliferative, angiogenic phase of the disease. Our animal models of diabetic retinopathy demonstrate similar decreases in retinal blood flow as seen in the early stages of diabetes in humans. Our studies also show an alteration in the retinal distribution of red blood cells, with the deep capillary layer receiving a reduced fraction, and with flow being diverted more towards the superficial vascular layer. Read More

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http://dx.doi.org/10.3233/BIR-180200DOI Listing

Rheological properties and efficacy of the formulation of hyaluronic acid with tamarind seed polysaccharide for arthritis.

Biorheology 2019 Mar 18. Epub 2019 Mar 18.

Across, 23, Geodudanji 1-Gil, Chuncheon, Korea.

Background: Tamarind seed polysaccharide (TSP) is used as a texturizing agent and a thickener in food and pharmaceutical products. There are no publications describing the addition of TSP to intra-articular injection formulations for arthritis.

Objective: The purpose of this study was to investigate the rheology and efficacy of the formulation of TSP with hyaluronic acid (HA) as a new material for injection for arthritis. Read More

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http://dx.doi.org/10.3233/BIR-190208DOI Listing
March 2019
2 Reads

Understanding endothelial glycocalyx function under flow shear stress from a molecular perspective.

Biorheology 2019 Jan 1. Epub 2019 Jan 1.

Department of Mechanical Engineering, University College London, Torrington Place, London, UK.

Background: The endothelial glycocalyx plays a pivotal role in regulating blood flow, filtering blood components, sensing and transducing mechanical signals. These functions are intimately related to its dynamics at the molecular level.

Objective: The objective of this research is to establish the relationship between the functions of the endothelial glycocalyx and its dynamics at the molecular level. Read More

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http://dx.doi.org/10.3233/BIR-180193DOI Listing
January 2019
1 Read

Microvascular hemodynamics: System properties1.

Authors:
Axel R Pries

Biorheology 2019 Feb 22. Epub 2019 Feb 22.

Department of Physiology, Charité Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

The hemodynamics of the microcirculation reflect system properties of the involved components. The blood itself is a complex suspension of water, small and large molecules and different cell types. Under most conditions, its rheologic properties are dominated by the different behaviour of fluid and cellular compartments. Read More

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http://dx.doi.org/10.3233/BIR-190207DOI Listing
February 2019

Shear-thickening fluids in biologically relevant agents.

Biorheology 2019 Feb 22. Epub 2019 Feb 22.

Asymptote Ltd., General Electric Healthcare, Cambridge, UK.

Background: The rheology of shear thickening fluids is well characterized for many physical applications, however the literature surrounding biologically or cryobiologically compatible shear thickening fluids is less well understood.

Objective: This study examined fluids consisting of corn-derived hydroxyethyl starch with a variety of sugars and cryoprotectants to characterize their shear-rate viscosity relationship. The objective was to establish if cryobiologically relevant materials could be used to afford biologics protection through shear-thickening. Read More

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http://dx.doi.org/10.3233/BIR-180196DOI Listing
February 2019

Comparative adhesive and migratory properties of mesenchymal stem cells from different tissues.

Biorheology 2019 Jan 24. Epub 2019 Jan 24.

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Background: Mesenchymal stem cells (MSC) are used in therapy, often by injection into the blood.

Objective: We aimed to compare the adhesive and migratory properties of MSC from umbilical cords (UCMSC), bone marrow (BMMSC) or trabecular bone (TBMSC), which might influence delivery to injured tissue.

Methods: MSC were perfused through glass capillaries coated with matrix proteins, collagen or fibronectin, or albumin. Read More

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http://dx.doi.org/10.3233/BIR-180185DOI Listing
January 2019

The endothelial glycocalyx: Barrier functions versus red cell hemodynamics: A model of steady state ultrafiltration through a bi-layer formed by a porous outer layer and more selective membrane-associated inner layer.

Biorheology 2019 Jan 10. Epub 2019 Jan 10.

Department of Bioengineering, Imperial College, London, UK.

Background: Ultrastructural investigations of the endothelial glycocalyx reveal a layer adjacent to the cell surface with a structure consistent with the primary  ultrafilter of vascular walls. Theory predicts this layer can be no greater than 200-300 nm thick, a result  to be reconciled with observations that red cells and large macromolecules are excluded  from a region 1 micrometer or more from the cell membrane.

Objective: To determine whether this apparent inconsistency might be accounted for by a model of steady state water and protein transport through a glycocalyx bi-layer formed by a porous outer layer in series with a more selective inner layer. Read More

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http://dx.doi.org/10.3233/BIR-180198DOI Listing
January 2019

Increased erythrocyte aggregation following an acute bout of eccentric isokinetic exercise does not exceed two days.

Biorheology 2018 ;55(1):15-24

Pamukkale University, Faculty of Medicine, Department of Physiology, Kinikli, Denizli, Turkey.

Background: Isokinetic exercise is used to reduce strength imbalance and to enhance performance.

Objective: The aim of this study was to investigate the acute effects of a single bout of eccentric isokinetic exercise on hemorheology (erythrocyte deformability and aggregation), total oxidant/antioxidant status (TOS/TAS) and oxidative stress index (OSI) in active individuals.

Methods: The study comprises 11 active, healthy, male subjects (mean age of 19. Read More

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http://dx.doi.org/10.3233/BIR-180175DOI Listing
January 2018
1 Read

Rheological parameters of saliva in comparison with taste examination.

Biorheology 2018 ;55(1):51-60

Chair and Clinic of Conservative Dentistry and Periodontology, University of Medical Sciences, Collegium Stomatologicum, Bukowska 70, Poznań, Poland.

Background: It is generally unknown if taste sensitivity is dependent upon saliva viscosity. The rheological properties of saliva result from many factors and it has been shown to behave as a non-Newtonian fluid whose viscosity decreases with increasing shear rate. Taste sensitivity may be quantitatively assayed by electro-gustometry. Read More

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http://dx.doi.org/10.3233/BIR-180171DOI Listing
January 2018

Characterization of the visco-elastic properties of hyaluronic acid.

Biorheology 2018 ;55(1):41-50

Biomedical Sciences Department, University of León, Spain.

Background: Hyaluronic acid (HA) is a polysaccharide present in almost all animal tissues, in which it carries out important biological functions, among them, the protection of the joints by lubricating them and dampening the tension in them.

Objective: This study compares the viscoelastic properties of several commercial preparations of HA, to determine their suitability for use as viscosupplementation therapy in joint pathology (osteoarthritis).

Methods: 4 HA hydrogels: Durolane®, Synocrom_Forte_One®, Synvisc_One® and Viscoplus_Matrix® and 4 HA solutions: Ostenil®, Ostenil_Plus®, Viscoplus_Gel® and Orthovisc® were analyzed to compare their viscoelatsic rheological parameters using an oscillatory-rotational rheometer. Read More

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http://dx.doi.org/10.3233/BIR-180174DOI Listing
January 2018
17 Reads

Biomechanical properties of veins cultured in vitro under elevated internal pressure.

Biorheology 2018 07;1(0):25-40

Osaka University, Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Toyonaka, OsakaJapan.

Background: The venous response to elevated blood pressure (BP) is of major importance because it is closely related to the etiology of venous diseases and the competency of vein grafts. In vitro culture experiments may provide useful information on the function of vein grafts because it is easier to separate mechanical and hemodynamic effects from other systemic influences compared to in vivo experiments.

Objective: To study the effects of BP elevation on wall dimensions and mechanical properties of in vitro cultured veins. Read More

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http://dx.doi.org/10.3233/BIR-180168DOI Listing
July 2018
6 Reads

Depletion-model-based numerical simulation of the kinetics of red blood cell aggregation under sinusoidal pulsatile flow.

Biorheology 2018 07;1(0):1-14

Department of Ocean System Engineering, Jeju National University, Jeju, Korea.

Background: Previous numerical modeling studies on red blood cell (RBC) aggregation have elucidated the inverse relationship between shear rate and RBC aggregation under steady flow. However, information on the cyclic variation in RBC aggregation under pulsatile flow remains lacking.

Objective: RBC aggregation was simulated to investigate the complex interrelationships among the parameters of RBC motion under pulsatile flow. Read More

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http://dx.doi.org/10.3233/BIR-170147DOI Listing

Rheological characterization of an in vitro model for salmonid chyme to quantify changes in feed composition.

Biorheology 2018 ;54(5-6):167-184

FMF Freiburg Material Research Centre and Institute for Macromolecular Chemistry, University of Freiburg, 79104 Freiburg, Germany.

Background: Developments in the production of aquacultural salmonid feeds in the last 20 years have led to extruded diets with extremely low water content and a shift from mainly marine fish based ingredients towards plant content. These changes expose the industry to the vagaries of the highly dynamic plant protein market. Resulting variations in the precise composition of aqua feeds may carry unpredictable consequences for water quality, since some plant ingredients cause undesirable reductions in the mechanical stability of faeces. Read More

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http://dx.doi.org/10.3233/BIR-18167DOI Listing
November 2018
3 Reads

Cross-sectional distributions of normal and abnormal red blood cells in capillary tubes determined by a new technique.

Biorheology 2018 ;54(5-6):153-165

Kansai University, Suita, Japan.

Background: In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability.

Objective: To quantitatively evaluate the effect of RBC deformability on their axial accumulation at a flow condition comparable to that in arterioles by developing a new observation system for accurate measurements of radial RBC positions in the cross section of capillary tubes. Read More

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http://dx.doi.org/10.3233/BIR-18166DOI Listing
November 2018

Recovery time course of erythrocyte deformability following exposure to shear is dependent upon conditioning shear stress.

Biorheology 2018 ;54(5-6):141-152

Menzies Health Institute Queensland, Griffith University, Queensland, Australia.

Background: Red blood cell (RBC) deformability may increase, or decrease, following application of shear stress ("shear conditioning"), depending upon the specific magnitude and duration of exposure. However, the time course of altered RBC deformability following shear remains unresolved.

Objective: We utilised shear conditioning known to increase (10 Pa) or decrease (64 Pa) RBC deformability and subsequently rested the cells; serial measurements of deformability during the rest period facilitated defining the time course of recoverability. Read More

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http://dx.doi.org/10.3233/BIR-17151DOI Listing
November 2018
4 Reads

Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl:WI) rats.

Biorheology 2018 ;54(5-6):127-140

Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.

Background: Age- and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents. Read More

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http://dx.doi.org/10.3233/BIR-17148DOI Listing
November 2018
3 Reads

Remodeling of the arterial wall: Response to restoration of normal blood flow after flow reduction.

Biorheology 2018 ;54(2-4):95-108

Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan.

Background: Although many studies have shown that arteries change diameter in response to chronic change in blood flow (BF), keeping wall shear stress (WSS) at physiologically normal levels, relatively little is known about the effects of flow restoration after flow reduction and also the role of vascular smooth muscle (VSM) during such a remodeling process.

Objective: To elucidate the biomechanical responses of the arterial wall to the restoration of normal BF after flow reduction and compare the results with our previous results observed in response to decreased BF alone.

Methods: Carotid artery BF in the Wistar rat was decreased by ligation and then restored to normal levels by release of the ligation. Read More

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http://dx.doi.org/10.3233/BIR-17146DOI Listing
November 2018
18 Reads

Articular cartilage response to a sliding load using two different-sized spherical indenters1.

Biorheology 2018 ;54(2-4):109-126

Laboratory of Physiology and Biomechanics of the Masticatory System, Center for Oral Medicine, Dental and Maxillo-Facial Surgery, University of Zurich, Switzerland.

Background: Cartilage surface contact geometry influences the deformational behavior and stress distribution throughout the extracellular matrix (ECM) under load.

Objective: To test the correlation between the mechanical and cellular response of articular cartilage when loaded with two different-sized spherical indenters under dynamic reciprocating sliding motion.

Methods: Articular cartilage explants were subjected to a reciprocating sliding load using a 17. Read More

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http://dx.doi.org/10.3233/BIR-16110DOI Listing
November 2018
3 Reads

In vitro measurement of platelet adhesion to intact endothelial cells under low shear conditions.

Biorheology 2018 ;54(2-4):51-65

Department of Mechanical Systems Engineering, Tokyo City University, Tokyo, Japan.

Background: Prediction of thrombus formation at intact arterial walls under low shear flow conditions is clinically important particularly for better prognoses of embolisation in cerebral aneurysms. Although a new mathematical model for this purpose is necessary, little quantitative information has been known about platelet adhesion to intact endothelial cells.

Objective: The objective of this study is to measure the number of platelets adhering to intact endothelial cells with a focus upon the influence of the shear rate. Read More

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http://dx.doi.org/10.3233/BIR-17139DOI Listing
November 2018
1 Read

Possible erythrocyte contributions to and exacerbation of the post-thrombolytic no-reflow phenomenon.

Biorheology 2018 ;54(2-4):81-93

Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73014, USA.

Background: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation.

Objective: To assess possible red cell contributions to post-thrombolytic no-reflow phenomenon. Read More

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http://dx.doi.org/10.3233/BIR-17144DOI Listing
November 2018
6 Reads

Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD).

Biorheology 2018 ;54(2-4):67-80

College of Engineering, Swansea University, Bay Campus, Swansea SA1 8EN, UK.

Background: The rheological properties of sputum may influence lung function and become modified in disease.

Objective: This study aimed to correlate the viscoelastic properties of sputum with clinical data on the severity of disease in patients with chronic obstructive pulmonary disease (COPD).

Methods: Sputum samples from COPD patients were investigated using rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM). Read More

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http://dx.doi.org/10.3233/BIR-17141DOI Listing
November 2018
11 Reads

Simultaneous assessment of blood coagulation and hematocrit levels in dielectric blood coagulometry.

Biorheology 2017 ;54(1):25-35

Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.

Background: In a whole blood coagulation test, the concentration of any in vitro diagnostic agent in plasma is dependent on the hematocrit level but its impact on the test result is unknown.

Objective: The aim of this work was to clarify the effects of reagent concentration, particularly Ca2+, and to find a method for hematocrit estimation compatible with the coagulation test.

Methods: Whole blood coagulation tests by dielectric blood coagulometry (DBCM) and rotational thromboelastometry were performed with various concentrations of Ca2+ or on samples with different hematocrit levels. Read More

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http://dx.doi.org/10.3233/BIR-16118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676769PMC
May 2018
8 Reads

Impact of training volume and intensity on RBC-NOS/NO pathway and endurance capacity.

Biorheology 2017 ;54(1):37-50

Department of Molecular and Cellular Sport Medicine, Institute of Sport Medicine and Cardiovascular Research, German Sport University Cologne, Germany.

Background: Acute exercise increases red blood cell-nitric oxide synthase (RBC-NOS) activation and RBC deformability but the effect of regular training remains unclear.

Objective: To detect the chronic effect of enduring moderate and high intensity training on the RBC-NOS/NO pathway and to detect a relation between RBC deformability and endurance capacity.

Methods: 38 healthy male subjects were randomly assigned to one of three training groups: High Volume Training (HVT; 120-140 beats per minute (bpm)), High Intensity Training (HIT; 160-180 bpm) and Moderate Intensity Training (MIT; 140-160 bpm). Read More

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http://dx.doi.org/10.3233/BIR-16121DOI Listing
May 2018
3 Reads

Effect of ovariectomy and Sideritis euboea extract administration on large artery mechanics, morphology, and structure in middle-aged rats.

Biorheology 2017 ;54(1):1-23

Laboratory for Research of the Musculoskeletal System, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available.

Objective: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of the carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea".

Methods: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups. Read More

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http://dx.doi.org/10.3233/BIR-16113DOI Listing
May 2018
11 Reads

The autodigestion hypothesis: Proteolytic receptor cleavage in rheological and cardiovascular cell dysfunction1.

Biorheology 2016 ;53(5-6):179-191

Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.

Transformation of circulating leukocytes from a dormant into an activated state with changing rheological properties leads to a major shift of their behavior in the microcirculation. Low levels of pseudopod formation or expression of adhesion molecules facilitate relatively free passage through microvessels while activated leukocytes with pseudopods and enhanced levels of adhesion membrane proteins become trapped in microvessels, attach to the endothelium and migrate into the tissue. The transformation of leukocytes into an activated state is seen in many diseases. Read More

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http://dx.doi.org/10.3233/BIR-17131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389039PMC

Prediction of the level and duration of shear stress exposure that induces subhemolytic damage to erythrocytes.

Biorheology 2016 ;53(5-6):237-249

Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Background: Current generation mechanical circulatory assist devices are designed to minimize high shears to blood for prolonged durations to avoid hemolysis. However, red blood cells (RBC) demonstrate impaired capacity to deform when exposed to shear stress (SS) well below the "hemolytic threshold".

Objective: We endeavored to identify how changes in the magnitude and duration of SS exposure alter RBC deformability and subsequently develop a model to predict erythrocyte subhemolytic damage. Read More

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http://dx.doi.org/10.3233/BIR-16120DOI Listing
July 2017
1 Read

Creep compliance rheology with a probe-like cylindrical geometry.

Biorheology 2016 ;53(5-6):221-236

Department of Mechanical and Aerospace Engineering, University of California Los Angeles, CA, USA.

Background: Rheology experiments have been performed on the vitreous humor, a soft gel that rests inside of the eye, to study its viscoelastic behavior and underlying macromolecular structure. A significant challenge for experimentalists is preserving the macromolecular structure when removing vitreous from in vivo conditions.

Objective: We have developed a novel probe-like rheometer geometry that allows us to perform shear rheology experiments on the vitreous humor in situ. Read More

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http://dx.doi.org/10.3233/BIR-16112DOI Listing
July 2017
10 Reads

Effect of circulating tissue factor on hypercoagulability in type 2 diabetes mellitus studied by rheometry and dielectric blood coagulometry.

Biorheology 2016 ;53(5-6):209-219

LE Development Department, R&D Division, Medical Business Unit, Imaging Products & Solutions Sector, Sony Corporation, Tokyo, Japan.

Background: Hypercoagulability in type 2 diabetes mellitus (T2DM) patients increases their risk of cardiovascular diseases.

Objective: The aim of this work was to investigate the hypercoagulation mechanism in T2DM patients in terms of circulating tissue factor (TF).

Methods: Whole blood coagulation tests by damped oscillation rheometry and dielectric blood coagulometry (DBCM) were performed. Read More

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http://dx.doi.org/10.3233/BIR-16107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389046PMC
July 2017
3 Reads

Viscoelastic properties of normal rat liver measured by ultrasound elastography: Comparison with oscillatory rheometry.

Biorheology 2016 ;53(5-6):193-207

School of Biomedical Engineering, Shenzhen University, Shenzhen, China.

Background: Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established.

Objective: To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to conventional rheometry methods. Read More

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http://dx.doi.org/10.3233/BIR-16091DOI Listing
July 2017
22 Reads
1.590 Impact Factor

Osteoarthritic synovial fluid and correlations with protein concentration.

Biorheology 2016 Nov;53(3-4):123-136

Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, BC, Canada.

Background: Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. The effects of osteoarthritis on the extensional rheology of synovial fluid in the knees are not fully understood and consequently require further study.

Objective: The purpose of this work is to study the extensional rheology of osteoarthritic synovial fluid and to investigate a possible correlation between synovial fluid protein concentration and extensional rheology. Read More

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http://dx.doi.org/10.3233/BIR-15086DOI Listing
November 2016

Osteoarthritic synovial fluid rheology and correlations with protein concentration.

Biorheology 2016 Nov;53(3-4):111-122

Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, BC, Canada.

Background: Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. Osteoarthritis is particularly common in the knees. The effects of osteoarthritis on the rheology of synovial fluid in the knees are not fully understood and consequently require further study. Read More

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http://dx.doi.org/10.3233/BIR-15078DOI Listing
November 2016

Biphasic impairment of erythrocyte deformability in response to repeated, short duration exposures of supraphysiological, subhaemolytic shear stress.

Biorheology 2016 Nov;53(3-4):137-149

School of Allied Health Sciences, Griffith University, Queensland, Australia.

Introduction: Despite current generation mechanical assist devices being designed to limit shear stresses and minimise damage to formed elements in blood, severe secondary complications suggestive of impaired rheological functioning are still observed. At present, the precise interactions between the magnitude-duration of shear stress exposure and the deformability of red blood cells (RBC) remain largely undescribed for repeated subhaemolytic shear stress duty-cycles of less than 15 s. Given that the time taken for blood to traverse mechanical devices (e. Read More

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http://dx.doi.org/10.3233/BIR-15108DOI Listing
November 2016
2 Reads

The effect of acute and short term normobaric hyperoxia on hemorheologic parameters.

Authors:
Pinar Ulker

Biorheology 2016 Nov;53(3-4):171-177

Department of Physiology, Medical Faculty, Akdeniz University, Kampus, 07070, Antalya, Turkey. Tel.: +90 242 2496960; Fax: +90 242

Backround:Possible toxic effects of hyperoxia have been reported previously. However, the number of studies investigating the influence of hyperoxia on blood cells is limited and there are no data regarding its hemorheological effects.

Objective: The aim of this study was to investigate the effects of acute hyperoxia, performed in human subjects at normal atmospheric pressure, on the rheological properties of blood. Read More

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http://dx.doi.org/10.3233/BIR-16096DOI Listing
November 2016
10 Reads

Large artery biomechanical, geometrical, and structural remodeling elicited by long-term propranolol administration in an animal model.

Biorheology 2016 Nov;53(3-4):151-170

Laboratory of Biomechanics, Center of Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Background: Limited attention has been paid to the role of beta-adrenergic blocking agents on large artery function/structure, despite being clinically useful for treating many forms of cardiovascular disease.

Objective: To assess long-term consequences of beta-blocker administration on the biomechanical properties, geometry, and histological structure of two major elastic arteries.

Methods: Healthy male rats received water with their food, while beta-blockade was produced in rats by adding propranolol in their drinking water. Read More

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http://dx.doi.org/10.3233/BIR-16090DOI Listing
November 2016

Rheological effects of macromolecular interactions in synovial fluid.

Biorheology 2016 Jul;53(2):49-67

Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada.

The rheological properties of synovial fluid (SF) are largely attributed to the presence of high molecular weight hyaluronan (HA). However, rheological differences between SF and pure HA solutions suggest that SF proteins actively contribute towards the bulk viscoelasticity of this biological fluid. Due to various experimental challenges involved with the rheometry of low-viscosity biological fluids, the macromolecular interactions in SF and their relative rheological importance are still a matter of active discussion. Read More

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http://dx.doi.org/10.3233/BIR-15104DOI Listing

Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline.

Biorheology 2016 07;53(2):93-107

Siberian State Medical University, Tomsk, Russia.

Background: Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. Read More

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http://dx.doi.org/10.3233/BIR-15100DOI Listing
July 2016
12 Reads

Heterogeneous phase fibrinolysis rates by damped oscillation rheometry.

Biorheology 2016 07;53(2):81-92

School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK, USA.

Background: Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion in a monolithic structure differs from the physical situation of thrombolytic therapy where surface reactions dominate. Read More

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http://dx.doi.org/10.3233/BIR-15089DOI Listing
July 2016
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Optical twisting to monitor the rheology of single cells.

Biorheology 2016 05;53(2):69-80

School of Physics and Astronomy, University of St Andrews, UK.

Background: Biological cells exhibit complex mechanical properties which determine their responses to applied force.

Objective: We developed an optical method to probe the temporal evolution of power-law rheology of single cells.

Methods: The method consisted in applying optically a constant mechanical torque to a birefringent microparticle bound to the cell membrane, and observing dynamics of the particle's in-plane rotation. Read More

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http://dx.doi.org/10.3233/BIR-15084DOI Listing
May 2016
2 Reads

Deformation and rupture of Dunaliella salina at high shear rates without the use of thickeners.

Biorheology 2016 03;53(1):1-11

Wissenschaftszentrum Weihenstephan für Ernährung und Landnutzung, Lehrstuhl für Systemverfahrenstechnik, Technical University of Munich (TUM), Freising, Germany.

Background: High-density cultures require operating below the critical threshold of shear stress, in order to avoid reducing the specific growth rate of the cells. When determining this threshold, direct inspection of the cells in flow provides insight into the conditions of shearing.

Objective: Aim of this study was using a novel rheo-optical setup for the observation of cells in laminar shear flow and the determination of the critical shear stress required to damage them in their natural environment. Read More

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http://dx.doi.org/10.3233/BIR-15057DOI Listing
March 2016
1 Read

The expression dynamics of mechanosensitive genes in extra-embryonic vasculature after heart starts to beat in chick embryo.

Biorheology 2016 02;53(1):33-47

Vascular Biology Laboratory, AU-KBC Research Centre, Chennai, Tamil Nadu, India.

Background: Fluid flow plays an important role in vascular development. However, the detailed mechanisms, particularly the link between flow and modulation of gene expression during vascular development, remain unexplored. In chick embryo, the key events of vascular development from initiation of heart beat to establishment of effective blood flow occur between the stages HH10 and HH13. Read More

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http://dx.doi.org/10.3233/BIR-15075DOI Listing
February 2016
5 Reads
1.590 Impact Factor

Protective effects of drag-reducing polymers in a rat model of monocrotaline-induced pulmonary hypertension.

Biorheology 2016 01;53(1):13-22

Department of Cardiovascular Diseases, The Second Clinical Medical College, Yangzhou University, Yangzhou, China.

Objectives: Drag-reducing polymers (DRPs) are blood-soluble macromolecules which may increase blood flow and reduce vascular resistance. The purpose of the present study was to observe the effect of DRPs on monocrotaline-induced pulmonary hypertension (PH) in the rat model.

Methods: A total of 64 male Wistar rats were randomly divided into four groups: Group I (pulmonary hypertension model + DRP treatment); Group II (pulmonary hypertension model + saline treatment); Group III (control + DRP treatment); Group IV (control + saline treatment). Read More

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http://dx.doi.org/10.3233/BIR-15062DOI Listing
January 2016
21 Reads

Hemorheological effects of secoisolariciresinol in ovariectomized rats.

Biorheology 2016 01;53(1):23-31

E.D. Goldberg Institute of Pharmacology and Regenerative Medicine, Russian Academy of Sciences, Tomsk, Russia.

Background: Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor.

Objective: We evaluated effects of secoisolariciresinol (SECO), a phytoestrogen, on hemorheological parameters and lipid peroxidation in a model of the age-related and/or surgical menopause induced by ovariectomy in rats.

Methods: Arterial blood was sampled from sham-operated female rats, ovariectomized rats (OVX), and OVX treated with SECO (OVXSECO) (20 mg/kg/day intragastrically for two weeks). Read More

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http://dx.doi.org/10.3233/BIR-15066DOI Listing
January 2016
15 Reads

Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation.

Biorheology 2015 ;52(5-6):353-77

Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

Integrins are a group of heterodimeric transmembrane receptors that play essential roles in cell-cell and cell-matrix interaction. Integrins are important in many physiological processes and diseases. Integrins acquire affinity to their ligand by undergoing molecular conformational changes called activation. Read More

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http://dx.doi.org/10.3233/BIR-15085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869873PMC
November 2016
8 Reads

Laudatio for Harry Goldsmith.

Authors:
Giles R Cokelet

Biorheology 2015 ;52(5-6):301-2

Bozeman, MT, USA.

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http://dx.doi.org/10.3233/BIR-150676DOI Listing
November 2016

Laudatio for Harry Goldsmith.

Authors:
Shu Chien

Biorheology 2015 ;52(5-6):295-9

Department of Bioengineering and Medicine; Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.3233/BIR-150675DOI Listing
November 2016
1 Read

Preface.

Biorheology 2015 ;52(5-6):293-4

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http://dx.doi.org/10.3233/BIR-150674DOI Listing
November 2016
2 Reads

Using cell monolayer rheology to probe average single cell mechanical properties.

Biorheology 2015 ;52(4):269-78

Biological Experimental Physics, Department of Physics FR 7.2, Saarland University, Germany.

The cell monolayer rheology technique consists of a commercial rotational rheometer that probes the mechanical properties of a monolayer of isolated cells. So far we have described properties of an entire monolayer. In this short communication, we show that we can deduce average single cell properties. Read More

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http://dx.doi.org/10.3233/BIR-15070DOI Listing
October 2016
4 Reads

Hemodynamics of the renal artery ostia with implications for their structural development and efficiency of flow.

Biorheology 2015 ;52(4):257-68

School of Chemical, Biological and Materials Engineering, University of Oklahoma, 100 E. Boyd SEC T301, Norman, OK, 73019, USA.

Background: Energy losses at tube or blood vessel orifices depend on the extent of flare as measured by the dimensionless ratio of the fillet radius of curvature to diameter (r/D).

Objective: The goal of this study was to assess the effect of ostial fillet radii on energy losses at the aorta-renal artery junctions since as much as a quarter of cardiac output passes through the kidneys.

Method: Pressure loss coefficients K for the renal artery ostia as a function of r/D have been determined for representative anatomical variants using finite volume simulations. Read More

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http://dx.doi.org/10.3233/BIR-15069DOI Listing
October 2016
3 Reads