2,138 results match your criteria Biorheology[Journal]


Usefulness of whole blood viscosity estimated by de Simeone's formula to predict left ventricular thrombus formation within one year following acute anterior myocardial infarction.

Biorheology 2020 May 20. Epub 2020 May 20.

Department of Cardiology, Trabzon Ahi Evren Training and Research Hospital, University of Health Science, Trabzon, Turkey.

Background: Despite improvements in treatment of ST-segment myocardial infarction (STEMI), thrombus formation in the left ventricle is still a concerning complication that may lead to systemic thromboembolism and stroke.

Objectives: To evaluate the predictive value of estimated whole blood viscosity (WBV) for left ventricular thrombus development in patients surviving an acute anterior myocardial infarction (AAMI).

Materials & Methods: Seven hundred eighty AAMI patients who were treated percutaneously were enrolled consecutively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-200240DOI Listing

Porcine bile viscosity is proportional to density.

Biorheology 2020 Apr 21. Epub 2020 Apr 21.

Department of Mechanical Systems Engineering, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.

Background: The gallbladder filling and emptying cycle controls bile flow into the duodenum. Disruption of this emptying and refilling cycle leads to bile stasis and subsequent gallstone formation. The bile flow rate is inversely proportional to its viscosity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190238DOI Listing

Viscoelastic characterization of diabetic and non-diabetic human adipose tissue.

Biorheology 2020 Feb 17. Epub 2020 Feb 17.

Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.

Background: Obesity-induced chronic inflammation and fibrosis in adipose tissue contributes to the progression of type 2 diabetes mellitus (DM). While fibrosis is known to induce mechanical stiffening of numerous tissue types, it is unknown whether DM is associated with alterations in adipose tissue mechanical properties.

Objective: The purpose of this study was to investigate whether DM is associated with differences in bulk viscoelastic properties of adipose tissue from diabetic (DM) and non-diabetic (NDM) obese subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190234DOI Listing
February 2020

Viscoelastic behavior of cardiomyocytes carrying LMNA mutations.

Biorheology 2020 Feb 19. Epub 2020 Feb 19.

Department of Engineering and Architecture, University of Trieste, Trieste, Italy.

Background: Laminopathies are genetic diseases caused by mutations in the nuclear lamina.

Objective: Given the clinical impact of laminopathies, understanding mechanical properties of cells bearing lamin mutations will lead to advancement in the treatment of heart failure.

Methods: Atomic force microscopy (AFM) was used to analyze the viscoelastic behavior of neonatal rat ventricular myocyte cells expressing three human lamin A/C gene (LMNA) mutations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190229DOI Listing
February 2020

Preface.

Authors:
Herbert Lipowsky

Biorheology 2019 ;56(2-3):73-75

xx, xx, xx, xx.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190233DOI Listing

Relative shedding of glycosaminoglycans from the endothelial glycocalyx during inflammation and their contribution to stiffness of the glycocalyx.

Biorheology 2019 ;56(2-3):191-205

Department of Biomedical Engineering, Penn State University, University Park, PA, USA.

Background: The endothelial (EC) surface layer (glycocalyx) has been shown to act as a barrier to transvascular exchange of solutes, and adhesion of leukocytes (WBCs) during the inflammatory process. It is a labile structure whose components are readily shed by the action of proteases and endoglycosidases. Details of shedding of specific constituents of the glycocalyx remain to be determined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190225DOI Listing

Nitrite may serve as a combination partner and a biomarker for the anti-cancer activity of RRx-001.

Biorheology 2019 ;56(4):221-235

Koc University School of Medicine, Sariyer, Istanbul, Turkey.

Background: RRx-001 is an anti-cancer immunotherapeutic that increases the sensitivity of drug resistant tumors via multiple mechanisms which involve binding to hemoglobin and enhancing nitrite reductase activity of deoxyhemoglobin.

Objective: In the present study, the effect of clinically used doses of RRx-001 on erythrocyte deformability was examined.

Methods: A dose dependent effect of RRx-001 (1-1000 micro molar) on erythrocyte deformability was measured by ektacytometer under hypoxia (n = 8). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190213DOI Listing

Tensile behavior and extensional viscosity of bile.

Biorheology 2019 ;56(4):237-252

National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.

Background: Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied.

Objective: We investigated the stretching of bile and evaluated its extensional viscosity using a filament-breakup device. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190216DOI Listing

Correlation of the cell mechanical behavior and quantified cytoskeletal parameters in normal and cancerous breast cell lines.

Biorheology 2019 ;56(4):207-219

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Cancerous transformation of cells affects their mechanical behavior and cytoskeleton structure.

Objective: The objective of this research is to investigate a correlation between mechanical properties and cytoskeletal structure features in cancer cell formation.

Methods: Micropipette aspiration was used to compare mechanical properties of normal (MCF10A) and cancerous (T47D) epithelial breast cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190214DOI Listing

Mechanobiology of the abluminal glycocalyx.

Biorheology 2019 ;56(2-3):101-112

Department of Biomedical Engineering and Intercollege Graduate Program of Bioengineering, The Pennsylvania State University, University Park, PA, USA.

Background: Endothelial cells (ECs) sense the forces from blood flow through the glycocalyx, a carbohydrate rich luminal surface layer decorating most cells, and through forces transmitted through focal adhesions (FAs) on the abluminal side of the cell.

Objectives: This perspective paper explores a complementary hypothesis, that glycocalyx molecules on the abluminal side of the EC between the basement membrane and the EC membrane, occupying the space outside of FAs, work in concert with FAs to sense blood flow-induced shear stress applied to the luminal surface.

Results: First, we summarize recent studies suggesting that the glycocalyx repels the plasma membrane away from the basement membrane, while integrin molecules attach to extracellular matrix (ECM) ligands. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190212DOI Listing

Effect of arterial curvature on hemodynamics and mass transport.

Biorheology 2019 ;56(4):253-263

Institute of Thermal Science of Technology, Shandong University, Jinan, China.

Background: Atherosclerotic lesions develop preferentially at certain sites in the human arterial system, such as the inner wall of curved segments and the outer wall of bifurcations. Local wall shear stress (WSS) and concentration of low density lipoprotein (LDL) have been identified as two important factors contributing to these lesions.

Objective: To determine if a connection exists between arterial curvature and the formation of atherosclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190215DOI Listing
June 2020
1 Read

The cancer cell glycocalyx proteoglycan Glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis.

Biorheology 2019 ;56(2-3):151-161

Department of Biomedical Engineering, The City College of New York, New York, NY, USA.

Background: Previous studies have demonstrated that the glycosaminoglycans (GAGs) heparan sulfate (HS) and hyaluronic acid (HA) are mechanosensors for interstitial flow on cancer cells. The proteins that link the GAGs to the cancer cell for mechanotransduction, however, are not known.

Objective: To assess whether the HS proteoglycan core proteins, Glypican-1 and Syndecan-1, or the HA receptor, CD44, provides the mechanical linkage to the cell. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180203DOI Listing
April 2020
3 Reads

Endothelial glycocalyx restoration by growth factors in diabetic nephropathy.

Biorheology 2019 ;56(2-3):163-179

Bristol Renal, Bristol Heart Institute, Translational Health Sciences, Bristol Medical School, University of Bristol, UK.

The endothelial glycocalyx (eGlx) constitutes the first barrier to protein in all blood vessels. This is particularly noteworthy in the renal glomerulus, an ultrafiltration barrier. Leakage of protein, such as albumin, across glomerular capillaries results in albumin in the urine (albuminuria). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180199DOI Listing
April 2020
2 Reads

Endothelial surface glycocalyx (ESG) components and ultra-structure revealed by stochastic optical reconstruction microscopy (STORM).

Biorheology 2019 ;56(2-3):77-88

Department of Biomedical Engineering, The City College of the City University of New York, \unskip\break New York, NY, USA.

Background: In order to play different roles in vascular functions as a mechanosensor to blood flows and as a barrier to transvascular exchange, the endothelial surface glycocalyx (ESG) should have an organized structure. Due to the limitations of optical and electron microscopy, the ultra-structure of ESG has not been revealed until the recent development of super-resolution optical microscopy, STORM.

Objectives: To investigate the ESG components and their organization on bEnd3 (mouse brain microvascular endothelial cells) monolayer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180204DOI Listing
April 2020
3 Reads

Numerical investigation of the effects of blood rheology and wall elasticity in abdominal aortic aneurysm under pulsatile flow conditions.

Biorheology 2019 ;56(1):51-71

Mechanical Engineering Department, Boğaziçi University, Bebek, Istanbul, Turkey.

Background: Previous studies on aneurysm modeling have focused on the blood rheology and vessel elasticity separately. The combined effects of blood shear thinning properties and wall elasticity need to be revealed.

Objective: To provide insights on how pulsatile hemodynamics vary with blood rheology and vessel elasticity for a developed abdominal aortic aneurysm (AAA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180202DOI Listing
December 2019
2 Reads

Endothelial barrier reinforcement relies on flow-regulated glycocalyx, a potential therapeutic target.

Biorheology 2019 ;56(2-3):131-149

Department of Bioengineering, Northeastern University, Boston, MA, USA.

Background: The onset of many disease processes depends on the function of the endothelial cell (EC) glycocalyx (GCX) which acts as a flow-dependent barrier to cellular infiltration and molecular transport across the blood vessel wall.

Objective: This review aims to examine these processes with the potential end goal of implementing GCX repair to restore EC barrier function and slow the progression of disease.

Methods: Cell and mouse studies were employed to examine the state of EC GCX in healthy versus disruptive flow conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766428PMC
April 2020
1 Read

Blood flow distribution and the endothelial surface layer in the diabetic retina.

Biorheology 2019 ;56(2-3):181-189

Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

Diabetic retinopathy is known as a microvascular complication of hyperglycemia, with a breakdown of the blood-retinal barrier, loss of pericytes, formation of microhemorrhages, early decreases in perfusion and areas of ischemia, with the latter speculated to induce the eventual proliferative, angiogenic phase of the disease. Our animal models of diabetic retinopathy demonstrate similar decreases in retinal blood flow as seen in the early stages of diabetes in humans. Our studies also show an alteration in the retinal distribution of red blood cells, with the deep capillary layer receiving a reduced fraction, and with flow being diverted more towards the superficial vascular layer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180200DOI Listing
April 2020
4 Reads

Rheological properties and efficacy of the formulation of hyaluronic acid with tamarind seed polysaccharide for arthritis.

Biorheology 2019 ;56(1):31-38

Across, 23, Geodudanji 1-Gil, Chuncheon, Korea.

Background: Tamarind seed polysaccharide (TSP) is used as a texturizing agent and a thickener in food and pharmaceutical products. There are no publications describing the addition of TSP to intra-articular injection formulations for arthritis.

Objective: The purpose of this study was to investigate the rheology and efficacy of the formulation of TSP with hyaluronic acid (HA) as a new material for injection for arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190208DOI Listing
December 2019
4 Reads

Understanding endothelial glycocalyx function under flow shear stress from a molecular perspective.

Biorheology 2019 ;56(2-3):89-100

Department of Mechanical Engineering, University College London, Torrington Place, London, UK.

Background: The endothelial glycocalyx plays a pivotal role in regulating blood flow, filtering blood components, sensing and transducing mechanical signals. These functions are intimately related to its dynamics at the molecular level.

Objective: The objective of this research is to establish the relationship between the functions of the endothelial glycocalyx and its dynamics at the molecular level. Read More

View Article

Download full-text PDF

Source
https://www.medra.org/servlet/aliasResolver?alias=iospress&a
Publisher Site
http://dx.doi.org/10.3233/BIR-180193DOI Listing
April 2020
3 Reads

Microvascular hemodynamics: System properties1.

Authors:
Axel R Pries

Biorheology 2019 ;56(1):1-13

Department of Physiology, Charité Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

The hemodynamics of the microcirculation reflect system properties of the involved components. The blood itself is a complex suspension of water, small and large molecules and different cell types. Under most conditions, its rheologic properties are dominated by the different behaviour of fluid and cellular compartments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-190207DOI Listing
December 2019
1 Read

Shear-thickening fluids in biologically relevant agents.

Biorheology 2019 ;56(1):39-50

Asymptote Ltd., General Electric Healthcare, Cambridge, UK.

Background: The rheology of shear thickening fluids is well characterized for many physical applications, however the literature surrounding biologically or cryobiologically compatible shear thickening fluids is less well understood.

Objective: This study examined fluids consisting of corn-derived hydroxyethyl starch with a variety of sugars and cryoprotectants to characterize their shear-rate viscosity relationship. The objective was to establish if cryobiologically relevant materials could be used to afford biologics protection through shear-thickening. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597967PMC
December 2019
1 Read

Comparative adhesive and migratory properties of mesenchymal stem cells from different tissues.

Biorheology 2019 ;56(1):15-30

Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Background: Mesenchymal stem cells (MSC) are used in therapy, often by injection into the blood.

Objective: We aimed to compare the adhesive and migratory properties of MSC from umbilical cords (UCMSC), bone marrow (BMMSC) or trabecular bone (TBMSC), which might influence delivery to injured tissue.

Methods: MSC were perfused through glass capillaries coated with matrix proteins, collagen or fibronectin, or albumin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180185DOI Listing
December 2019
1 Read

The endothelial glycocalyx: Barrier functions versus red cell hemodynamics: A model of steady state ultrafiltration through a bi-layer formed by a porous outer layer and more selective membrane-associated inner layer.

Biorheology 2019 ;56(2-3):113-130

Department of Bioengineering, Imperial College, London, UK.

Background: Ultrastructural investigations of the endothelial glycocalyx reveal a layer adjacent to the cell surface with a structure consistent with the primary  ultrafilter of vascular walls. Theory predicts this layer can be no greater than 200-300 nm thick, a result  to be reconciled with observations that red cells and large macromolecules are excluded  from a region 1 micrometer or more from the cell membrane.

Objective: To determine whether this apparent inconsistency might be accounted for by a model of steady state water and protein transport through a glycocalyx bi-layer formed by a porous outer layer in series with a more selective inner layer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180198DOI Listing
April 2020
1 Read

Increased erythrocyte aggregation following an acute bout of eccentric isokinetic exercise does not exceed two days.

Biorheology 2018 ;55(1):15-24

Pamukkale University, Faculty of Medicine, Department of Physiology, Kinikli, Denizli, Turkey.

Background: Isokinetic exercise is used to reduce strength imbalance and to enhance performance.

Objective: The aim of this study was to investigate the acute effects of a single bout of eccentric isokinetic exercise on hemorheology (erythrocyte deformability and aggregation), total oxidant/antioxidant status (TOS/TAS) and oxidative stress index (OSI) in active individuals.

Methods: The study comprises 11 active, healthy, male subjects (mean age of 19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180175DOI Listing
June 2019
3 Reads

Rheological parameters of saliva in comparison with taste examination.

Biorheology 2018 ;55(1):51-60

Chair and Clinic of Conservative Dentistry and Periodontology, University of Medical Sciences, Collegium Stomatologicum, Bukowska 70, Poznań, Poland.

Background: It is generally unknown if taste sensitivity is dependent upon saliva viscosity. The rheological properties of saliva result from many factors and it has been shown to behave as a non-Newtonian fluid whose viscosity decreases with increasing shear rate. Taste sensitivity may be quantitatively assayed by electro-gustometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-180171DOI Listing
June 2019
3 Reads

Characterization of the visco-elastic properties of hyaluronic acid.

Biorheology 2018 ;55(1):41-50

Biomedical Sciences Department, University of León, Spain.

Background: Hyaluronic acid (HA) is a polysaccharide present in almost all animal tissues, in which it carries out important biological functions, among them, the protection of the joints by lubricating them and dampening the tension in them.

Objective: This study compares the viscoelastic properties of several commercial preparations of HA, to determine their suitability for use as viscosupplementation therapy in joint pathology (osteoarthritis).

Methods: 4 HA hydrogels: Durolane®, Synocrom_Forte_One®, Synvisc_One® and Viscoplus_Matrix® and 4 HA solutions: Ostenil®, Ostenil_Plus®, Viscoplus_Gel® and Orthovisc® were analyzed to compare their viscoelatsic rheological parameters using an oscillatory-rotational rheometer. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-180174DOI Listing
June 2019
41 Reads

Biomechanical properties of veins cultured in vitro under elevated internal pressure.

Biorheology 2018 07;1(0):25-40

Osaka University, Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Toyonaka, OsakaJapan.

Background: The venous response to elevated blood pressure (BP) is of major importance because it is closely related to the etiology of venous diseases and the competency of vein grafts. In vitro culture experiments may provide useful information on the function of vein grafts because it is easier to separate mechanical and hemodynamic effects from other systemic influences compared to in vivo experiments.

Objective: To study the effects of BP elevation on wall dimensions and mechanical properties of in vitro cultured veins. Read More

View Article

Download full-text PDF

Source
https://www.medra.org/servlet/aliasResolver?alias=iospress&a
Publisher Site
http://dx.doi.org/10.3233/BIR-180168DOI Listing
July 2018
26 Reads

Depletion-model-based numerical simulation of the kinetics of red blood cell aggregation under sinusoidal pulsatile flow.

Biorheology 2018 07;1(0):1-14

Department of Ocean System Engineering, Jeju National University, Jeju, Korea.

Background: Previous numerical modeling studies on red blood cell (RBC) aggregation have elucidated the inverse relationship between shear rate and RBC aggregation under steady flow. However, information on the cyclic variation in RBC aggregation under pulsatile flow remains lacking.

Objective: RBC aggregation was simulated to investigate the complex interrelationships among the parameters of RBC motion under pulsatile flow. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-170147DOI Listing
July 2018
4 Reads

Rheological characterization of an in vitro model for salmonid chyme to quantify changes in feed composition.

Biorheology 2018 ;54(5-6):167-184

FMF Freiburg Material Research Centre and Institute for Macromolecular Chemistry, University of Freiburg, 79104 Freiburg, Germany.

Background: Developments in the production of aquacultural salmonid feeds in the last 20 years have led to extruded diets with extremely low water content and a shift from mainly marine fish based ingredients towards plant content. These changes expose the industry to the vagaries of the highly dynamic plant protein market. Resulting variations in the precise composition of aqua feeds may carry unpredictable consequences for water quality, since some plant ingredients cause undesirable reductions in the mechanical stability of faeces. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-18167DOI Listing
November 2018
4 Reads

Cross-sectional distributions of normal and abnormal red blood cells in capillary tubes determined by a new technique.

Biorheology 2018 ;54(5-6):153-165

Kansai University, Suita, Japan.

Background: In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability.

Objective: To quantitatively evaluate the effect of RBC deformability on their axial accumulation at a flow condition comparable to that in arterioles by developing a new observation system for accurate measurements of radial RBC positions in the cross section of capillary tubes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-18166DOI Listing
November 2018
3 Reads

Recovery time course of erythrocyte deformability following exposure to shear is dependent upon conditioning shear stress.

Biorheology 2018 ;54(5-6):141-152

Menzies Health Institute Queensland, Griffith University, Queensland, Australia.

Background: Red blood cell (RBC) deformability may increase, or decrease, following application of shear stress ("shear conditioning"), depending upon the specific magnitude and duration of exposure. However, the time course of altered RBC deformability following shear remains unresolved.

Objective: We utilised shear conditioning known to increase (10 Pa) or decrease (64 Pa) RBC deformability and subsequently rested the cells; serial measurements of deformability during the rest period facilitated defining the time course of recoverability. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-17151DOI Listing
November 2018
5 Reads

Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl:WI) rats.

Biorheology 2018 ;54(5-6):127-140

Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Hungary.

Background: Age- and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-17148DOI Listing
November 2018
4 Reads

Remodeling of the arterial wall: Response to restoration of normal blood flow after flow reduction.

Biorheology 2018 ;54(2-4):95-108

Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan.

Background: Although many studies have shown that arteries change diameter in response to chronic change in blood flow (BF), keeping wall shear stress (WSS) at physiologically normal levels, relatively little is known about the effects of flow restoration after flow reduction and also the role of vascular smooth muscle (VSM) during such a remodeling process.

Objective: To elucidate the biomechanical responses of the arterial wall to the restoration of normal BF after flow reduction and compare the results with our previous results observed in response to decreased BF alone.

Methods: Carotid artery BF in the Wistar rat was decreased by ligation and then restored to normal levels by release of the ligation. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-17146DOI Listing
November 2018
42 Reads

Articular cartilage response to a sliding load using two different-sized spherical indenters1.

Biorheology 2018 ;54(2-4):109-126

Laboratory of Physiology and Biomechanics of the Masticatory System, Center for Oral Medicine, Dental and Maxillo-Facial Surgery, University of Zurich, Switzerland.

Background: Cartilage surface contact geometry influences the deformational behavior and stress distribution throughout the extracellular matrix (ECM) under load.

Objective: To test the correlation between the mechanical and cellular response of articular cartilage when loaded with two different-sized spherical indenters under dynamic reciprocating sliding motion.

Methods: Articular cartilage explants were subjected to a reciprocating sliding load using a 17. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-16110DOI Listing
November 2018
5 Reads

In vitro measurement of platelet adhesion to intact endothelial cells under low shear conditions.

Biorheology 2018 ;54(2-4):51-65

Department of Mechanical Systems Engineering, Tokyo City University, Tokyo, Japan.

Background: Prediction of thrombus formation at intact arterial walls under low shear flow conditions is clinically important particularly for better prognoses of embolisation in cerebral aneurysms. Although a new mathematical model for this purpose is necessary, little quantitative information has been known about platelet adhesion to intact endothelial cells.

Objective: The objective of this study is to measure the number of platelets adhering to intact endothelial cells with a focus upon the influence of the shear rate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-17139DOI Listing
November 2018
3 Reads

Possible erythrocyte contributions to and exacerbation of the post-thrombolytic no-reflow phenomenon.

Biorheology 2018 ;54(2-4):81-93

Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73014, USA.

Background: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation.

Objective: To assess possible red cell contributions to post-thrombolytic no-reflow phenomenon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-17144DOI Listing
November 2018
8 Reads

Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD).

Biorheology 2018 ;54(2-4):67-80

College of Engineering, Swansea University, Bay Campus, Swansea SA1 8EN, UK.

Background: The rheological properties of sputum may influence lung function and become modified in disease.

Objective: This study aimed to correlate the viscoelastic properties of sputum with clinical data on the severity of disease in patients with chronic obstructive pulmonary disease (COPD).

Methods: Sputum samples from COPD patients were investigated using rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-17141DOI Listing
November 2018
13 Reads

Simultaneous assessment of blood coagulation and hematocrit levels in dielectric blood coagulometry.

Biorheology 2017 ;54(1):25-35

Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan.

Background: In a whole blood coagulation test, the concentration of any in vitro diagnostic agent in plasma is dependent on the hematocrit level but its impact on the test result is unknown.

Objective: The aim of this work was to clarify the effects of reagent concentration, particularly Ca2+, and to find a method for hematocrit estimation compatible with the coagulation test.

Methods: Whole blood coagulation tests by dielectric blood coagulometry (DBCM) and rotational thromboelastometry were performed with various concentrations of Ca2+ or on samples with different hematocrit levels. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-16118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676769PMC
May 2018
12 Reads

Impact of training volume and intensity on RBC-NOS/NO pathway and endurance capacity.

Biorheology 2017 ;54(1):37-50

Department of Molecular and Cellular Sport Medicine, Institute of Sport Medicine and Cardiovascular Research, German Sport University Cologne, Germany.

Background: Acute exercise increases red blood cell-nitric oxide synthase (RBC-NOS) activation and RBC deformability but the effect of regular training remains unclear.

Objective: To detect the chronic effect of enduring moderate and high intensity training on the RBC-NOS/NO pathway and to detect a relation between RBC deformability and endurance capacity.

Methods: 38 healthy male subjects were randomly assigned to one of three training groups: High Volume Training (HVT; 120-140 beats per minute (bpm)), High Intensity Training (HIT; 160-180 bpm) and Moderate Intensity Training (MIT; 140-160 bpm). Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-16121DOI Listing
May 2018
6 Reads

Effect of ovariectomy and Sideritis euboea extract administration on large artery mechanics, morphology, and structure in middle-aged rats.

Biorheology 2017 ;54(1):1-23

Laboratory for Research of the Musculoskeletal System, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available.

Objective: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of the carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea".

Methods: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-16113DOI Listing
May 2018
26 Reads

The autodigestion hypothesis: Proteolytic receptor cleavage in rheological and cardiovascular cell dysfunction1.

Biorheology 2016 ;53(5-6):179-191

Department of Bioengineering, The Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.

Transformation of circulating leukocytes from a dormant into an activated state with changing rheological properties leads to a major shift of their behavior in the microcirculation. Low levels of pseudopod formation or expression of adhesion molecules facilitate relatively free passage through microvessels while activated leukocytes with pseudopods and enhanced levels of adhesion membrane proteins become trapped in microvessels, attach to the endothelium and migrate into the tissue. The transformation of leukocytes into an activated state is seen in many diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-17131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389039PMC
July 2017
1 Read

Prediction of the level and duration of shear stress exposure that induces subhemolytic damage to erythrocytes.

Biorheology 2016 ;53(5-6):237-249

Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Background: Current generation mechanical circulatory assist devices are designed to minimize high shears to blood for prolonged durations to avoid hemolysis. However, red blood cells (RBC) demonstrate impaired capacity to deform when exposed to shear stress (SS) well below the "hemolytic threshold".

Objective: We endeavored to identify how changes in the magnitude and duration of SS exposure alter RBC deformability and subsequently develop a model to predict erythrocyte subhemolytic damage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-16120DOI Listing
July 2017
4 Reads

Creep compliance rheology with a probe-like cylindrical geometry.

Biorheology 2016 ;53(5-6):221-236

Department of Mechanical and Aerospace Engineering, University of California Los Angeles, CA, USA.

Background: Rheology experiments have been performed on the vitreous humor, a soft gel that rests inside of the eye, to study its viscoelastic behavior and underlying macromolecular structure. A significant challenge for experimentalists is preserving the macromolecular structure when removing vitreous from in vivo conditions.

Objective: We have developed a novel probe-like rheometer geometry that allows us to perform shear rheology experiments on the vitreous humor in situ. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-16112DOI Listing
July 2017
13 Reads

Effect of circulating tissue factor on hypercoagulability in type 2 diabetes mellitus studied by rheometry and dielectric blood coagulometry.

Biorheology 2016 ;53(5-6):209-219

LE Development Department, R&D Division, Medical Business Unit, Imaging Products & Solutions Sector, Sony Corporation, Tokyo, Japan.

Background: Hypercoagulability in type 2 diabetes mellitus (T2DM) patients increases their risk of cardiovascular diseases.

Objective: The aim of this work was to investigate the hypercoagulation mechanism in T2DM patients in terms of circulating tissue factor (TF).

Methods: Whole blood coagulation tests by damped oscillation rheometry and dielectric blood coagulometry (DBCM) were performed. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-16107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389046PMC
July 2017
5 Reads

Viscoelastic properties of normal rat liver measured by ultrasound elastography: Comparison with oscillatory rheometry.

Biorheology 2016 ;53(5-6):193-207

School of Biomedical Engineering, Shenzhen University, Shenzhen, China.

Background: Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established.

Objective: To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to conventional rheometry methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-16091DOI Listing
July 2017
50 Reads
1.590 Impact Factor

Osteoarthritic synovial fluid and correlations with protein concentration.

Biorheology 2016 Nov;53(3-4):123-136

Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, BC, Canada.

Background: Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. The effects of osteoarthritis on the extensional rheology of synovial fluid in the knees are not fully understood and consequently require further study.

Objective: The purpose of this work is to study the extensional rheology of osteoarthritic synovial fluid and to investigate a possible correlation between synovial fluid protein concentration and extensional rheology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-15086DOI Listing
November 2016
2 Reads

Osteoarthritic synovial fluid rheology and correlations with protein concentration.

Biorheology 2016 Nov;53(3-4):111-122

Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, BC, Canada.

Background: Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. Osteoarthritis is particularly common in the knees. The effects of osteoarthritis on the rheology of synovial fluid in the knees are not fully understood and consequently require further study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-15078DOI Listing
November 2016
2 Reads

Biphasic impairment of erythrocyte deformability in response to repeated, short duration exposures of supraphysiological, subhaemolytic shear stress.

Biorheology 2016 Nov;53(3-4):137-149

School of Allied Health Sciences, Griffith University, Queensland, Australia.

Introduction: Despite current generation mechanical assist devices being designed to limit shear stresses and minimise damage to formed elements in blood, severe secondary complications suggestive of impaired rheological functioning are still observed. At present, the precise interactions between the magnitude-duration of shear stress exposure and the deformability of red blood cells (RBC) remain largely undescribed for repeated subhaemolytic shear stress duty-cycles of less than 15 s. Given that the time taken for blood to traverse mechanical devices (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-15108DOI Listing
November 2016
3 Reads

The effect of acute and short term normobaric hyperoxia on hemorheologic parameters.

Authors:
Pinar Ulker

Biorheology 2016 Nov;53(3-4):171-177

Department of Physiology, Medical Faculty, Akdeniz University, Kampus, 07070, Antalya, Turkey. Tel.: +90 242 2496960; Fax: +90 242

Backround:Possible toxic effects of hyperoxia have been reported previously. However, the number of studies investigating the influence of hyperoxia on blood cells is limited and there are no data regarding its hemorheological effects.

Objective: The aim of this study was to investigate the effects of acute hyperoxia, performed in human subjects at normal atmospheric pressure, on the rheological properties of blood. Read More

View Article

Download full-text PDF

Source
http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/BIR-16096DOI Listing
November 2016
18 Reads

Large artery biomechanical, geometrical, and structural remodeling elicited by long-term propranolol administration in an animal model.

Biorheology 2016 Nov;53(3-4):151-170

Laboratory of Biomechanics, Center of Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Background: Limited attention has been paid to the role of beta-adrenergic blocking agents on large artery function/structure, despite being clinically useful for treating many forms of cardiovascular disease.

Objective: To assess long-term consequences of beta-blocker administration on the biomechanical properties, geometry, and histological structure of two major elastic arteries.

Methods: Healthy male rats received water with their food, while beta-blockade was produced in rats by adding propranolol in their drinking water. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/BIR-16090DOI Listing
November 2016
2 Reads