6,579 results match your criteria Bioresource technology[Journal]


A comparison of microbial fuel cell and microbial electrolysis cell biosensors for real-time environmental monitoring.

Bioelectrochemistry 2018 Dec 1;126:105-112. Epub 2018 Dec 1.

McGill University, Bioresource Engineering Department, 21111 Lakeshore Rd., Ste-Anne-de-Bellevue, QC H9X 3V9, Canada; National Research Council of Canada, 6100 Royalmount Ave, Montreal, QC H4P 2R2, Canada. Electronic address:

This study compares the biosensing performance of a microbial fuel cell (MFC) and a microbial electrolysis cell (MEC). Initial tests provided a qualitative comparison of MFC and MEC currents after the anode compartment liquid (anolyte) was spiked with acetate, or sulphates of NH, Na, Mg, Fe, or a fertilizer solution. Current measurements showed that the MFC sensor had a faster response time, higher sensitivity, and faster recovery time after the spike. Read More

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December 2018

Reclassification of Paenibacillus thermophilus Zhou et al. 2013 as a later heterotypic synonym of Paenibacillus macerans (Schardinger 1905) Ash et al. 1994.

Int J Syst Evol Microbiol 2018 Dec 12. Epub 2018 Dec 12.

1​Central Region Agricultural Research Center, National Agriculture and Food Research Organization, Nasushiobara, Tochigi 329-2793, Japan.

The taxonomic status of Paenibacillus thermophilus was analyzed using genomic and phenotypic approaches. The results of RNA polymerase beta subunit gene sequence comparisons indicated that two type strains of P. thermophilus (DSM 24746 and JCM 17693) and Paenibacillus macerans ATCC 8244 shared 100 % sequence similarity. Read More

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December 2018

Effectiveness of pharmacist-led educational interventions on self-care activities and glycemic control of type 2 diabetes patients: a systematic review and meta-analysis.

Patient Prefer Adherence 2018 21;12:2457-2474. Epub 2018 Nov 21.

School of Pharmacy, Monash University Malaysia, Selangor 47500, Malaysia,

Background: Effectiveness of pharmacist-led educational interventions on self-care activities and glycemic control of type 2 diabetes mellitus (T2DM) patients is vague. The purpose of this review is to appraise the effect of pharmacist-led educational interventions on self-care activities and levels of glycated hemoglobin of T2DM patients.

Methods: Five electronic databases were searched from date of database inception to September 2017. Read More

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November 2018

Preservation of boar semen: An update.

Reprod Domest Anim 2018 Dec 8. Epub 2018 Dec 8.

Laboratory of Reproductive Medicine and Molecular Endocrinology, Center of Translational Medicine - Scientific and Technological Bioresource Nucleus (CEMT-BIOREN).

In the pork industry, artificial insemination and the storage of boar semen in liquid at 17°C are routinely applied to optimize the ejaculate and bring about rapid genetic changes that are reflected in the animal protein. Although the results are satisfactory, they are below what occurs with natural mating. It is currently possible to preserve boar semen with storage at 17°C and slow freezing, since to date there is only one study on vitrification, with negative results applicable only in the case of implementing an intracytoplasmic sperm injection. Read More

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December 2018
2 Reads

OsTSD2-mediated cell wall modification affects ion homeostasis and salt tolerance.

Plant Cell Environ 2018 Dec 7. Epub 2018 Dec 7.

Hainan Key Laboratory for Sustainable Utilisation of Tropical Bioresource, Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, 570288, China.

Salt stress is a major environmental threat to meeting the food demands of an increasing global population. The identification and exploitation of salt adaption mechanisms in plants is therefore vital for crop breeding. We here define the rice mutant (sstm1) whose salt-sensitivity was unambiguously assigned to a single T-DNA insertion through segregational analysis following backcrossing to the wild type line. Read More

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December 2018
1 Read

Automated adherent cell elimination by a high-speed laser mediated by a light-responsive polymer.

Commun Biol 2018 7;1:218. Epub 2018 Dec 7.

4Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5th, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565 Japan.

Conventional cell handling and sorting methods require manual labor, which decreases both cell quality and quantity. To purify adherent cultured cells, cell purification technologies that are high throughput without dissociation and can be utilized in an on-demand manner are expected. Here, we developed a Laser-induced, Light-responsive-polymer-Activated, Cell Killing (LiLACK) system that enables high-speed and on-demand adherent cell sectioning and purification. Read More

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December 2018

A novel intragenic deletion in in a Japanese patient with Dandy-Walker malformation.

Hum Genome Var 2019 5;6. Epub 2018 Dec 5.

8Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, 187-8551 Japan.

Dandy-Walker malformation (DWM) is a rare congenital malformation defined by hypoplasia of the cerebellar vermis and cystic dilatation of the fourth ventricle. Oligophrenin-1 is mutated in X-linked intellectual disability with or without cerebellar hypoplasia. Here, we report a Japanese DWM patient carrying a novel intragenic 13. Read More

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December 2018

Proteome modifications on tomato under extreme high light induced-stress.

Proteome Sci 2018 24;16:20. Epub 2018 Nov 24.

1Department of Bioresource Engineering, Macdonald Campus, McGill University, 21,111 Lakeshore Boulevard, Sainte-Anne-de-Bellevue, Quebec H9X 3V9 Canada.

Background: Abiotic stress reduces photosynthetic yield and plant growth, negatively impacting global crop production and is a major constraint faced by agriculture. However, the knowledge on the impact on plants under extremely high irradiance is limited. We present the first in-depth proteomics analysis of plants treated with a method developed by our research group to generate a light gradient using an extremely intense light. Read More

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November 2018

Draft Genome Sequence of Faecalimonas umbilicata JCM 30896, an Acetate-Producing Bacterium Isolated from Human Feces.

Microbiol Resour Announc 2018 Sep 6;7(9). Epub 2018 Sep 6.

Microbe Division/Japan Collection of Microorganisms, RIKEN BioResource Research Center, Tsukuba, Japan.

Here, we report the draft genome sequence of Faecalimonas umbilicata JCM 30896, an acetate-producing bacterium isolated from human feces. The genomic analysis reveals genes for acetate and vitamin B synthesis and will facilitate the study of the role of this strain in the human gut. Read More

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September 2018

Draft Genome Sequence of Blautia sp. Strain BCRC 81119, Isolated from Human Feces.

Microbiol Resour Announc 2018 Aug 2;7(4). Epub 2018 Aug 2.

Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan, Republic of China.

Blautia sp. strain BCRC 81119 was isolated from a fecal sample from a 34-year-old male in Taiwan. The genome assembly comprised 4,098,441 bp, with a 43. Read More

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Complete Genome Sequence of Ferriphaselus amnicola Strain OYT1, a Neutrophilic, Stalk-Forming, Iron-Oxidizing Bacterium.

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Japan Collection of Microorganisms, RIKEN BioResource Research Center, Tsukuba, Ibaraki, Japan.

Ferriphaselus amnicola is a freshwater, neutrophilic, iron-oxidizing bacterium that produces extracellular twisted-ribbon-like iron biominerals called stalks. Here, we report the 2.72-Mb closed genome sequence of F. Read More

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September 2018

Complete Genome Sequences of Seven Strains from Japan.

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Laboratory of Bioresource and Technology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kahiwa, Chiba, Japan.

We present the complete genomic RNA sequences of seven isolates of discovered in diseased legume plants in various regions in Japan. These sequences and the published viral sequences were compared with respect to nucleotide percentages. Their phylogenetic analysis showed that all the isolates belong to subgroup IA. Read More

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September 2018

Draft Genome Sequences of Mycolicibacter senuensis Isolate GF74 and Mycobacterium colombiense Isolates GF28 and GF76 from a Swine Farm in Japan.

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Department of Microbiology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.

Several nontuberculous mycobacteria (NTM) occasionally infect humans and animals. Here, we report the draft genome sequences of Mycolicibacter senuensis isolate GF74 (4,792,997 bp) and Mycobacterium colombiense isolates GF28 and GF76 (5,473,554 bp and 5,426,852 bp, respectively) isolated from a swine farm in Japan. These sequences provide further information on NTM research. Read More

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September 2018

Complete Genome Sequence of Lactobacillus curvatus NFH-Km12, Isolated from the Japanese Traditional Fish Fermented Food Kabura-zushi.

Microbiol Resour Announc 2018 Jul 12;7(1). Epub 2018 Jul 12.

Laboratory of Food Hygiene, Department of Food Bioscience and Biotechnology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.

Kabura-zushi is a traditional Japanese fermented food made from yellowtail, rice, salt, and kōji. In this study, the complete genomic sequence of Lactobacillus curvatus NFH-Km12, isolated from this unique food, is reported. NFH-Km12 has a 1. Read More

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Analysis of 51 proposed hypertrophic cardiomyopathy genes from genome sequencing data in sarcomere negative cases has negligible diagnostic yield.

Genet Med 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Purpose: Increasing numbers of genes are being implicated in Mendelian disorders and incorporated into clinical test panels. However, lack of evidence supporting the gene-disease relationship can hinder interpretation. We explored the utility of testing 51 additional genes for hypertrophic cardiomyopathy (HCM), one of the most commonly tested Mendelian disorders. Read More

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December 2018

Advances in microbial lignin degradation and its applications.

Curr Opin Biotechnol 2018 Dec 7;56:179-186. Epub 2018 Dec 7.

Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan. Electronic address:

Lignocellulosic biomass represents a crucial resource for achieving sustainable development by replacing petroleum-based production systems. Lignin, a major component of plant cell walls, has significant potential as a bioresource; however, it is an obstacle in lignocellulosic biomass utilization due to its recalcitrance. Consequently, decomposition or removal of lignin is a crucial step to utilize cell wall components. Read More

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December 2018

Carboxylated nanocellulose foams as superabsorbents.

J Colloid Interface Sci 2018 Dec 1;538:433-439. Epub 2018 Dec 1.

Bioresource Processing Research Institute of Australia (BioPRIA), Department of Chemical Engineering, Monash University, VIC 3800, Australia. Electronic address:

Hypothesis: Carboxylated nanocellulose fibres formed into foam structures can demonstrate superabsorption capacity. Their performance can be engineered by changing process variables.

Experiments: TEMPO-oxidised cellulose nanofibres of varying concentration and surface charge are produced from hardwood kraft pulp. Read More

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December 2018

Arthropod venoms: Biochemistry, Ecology and Evolution.

Toxicon 2018 Dec 6. Epub 2018 Dec 6.

Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012. India. Electronic address:

Comprising of over a million described species of highly diverse invertebrates, Arthropoda is amongst the most successful animal lineages to have colonized aerial, terrestrial, and aquatic domains. Venom, one of the many fascinating traits to have evolved in various members of this phylum, has underpinned their adaptation to diverse habitats. Over millions of years of evolution, arthropods have evolved ingenious ways of delivering venom in their targets for self-defence and predation. Read More

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December 2018

Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning.

Neurobiol Learn Mem 2018 Dec 7. Epub 2018 Dec 7.

Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan; Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan; School of Life Science, South China Normal University, Guangzhou 510631, China. Electronic address:

CaMKII is a pivotal kinase that plays essential roles in synaptic plasticity. Apart from its signaling function, the structural function of CaMKII is becoming clear. CaMKII - F-actin interaction stabilizes actin cytoskeleton in a dendritic spine. Read More

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December 2018

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

Background: Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes.

Methods: We did two separate genome-wide association studies (GWAS) and a meta-analysis of pulmonary arterial hypertension. Read More

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December 2018

Complex structural variants in Mendelian disorders: identification and breakpoint resolution using short- and long-read genome sequencing.

Genome Med 2018 Dec 7;10(1):95. Epub 2018 Dec 7.

Department of Haematology, University of Cambridge, NHS Blood and Transplant Centre, Cambridge, CB2 0PT, UK.

Background: Studies have shown that complex structural variants (cxSVs) contribute to human genomic variation and can cause Mendelian disease. We aimed to identify cxSVs relevant to Mendelian disease using short-read whole-genome sequencing (WGS), resolve the precise variant configuration and investigate possible mechanisms of cxSV formation.

Methods: We performed short-read WGS and analysis of breakpoint junctions to identify cxSVs in a cohort of 1324 undiagnosed rare disease patients. Read More

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December 2018

Berberis lycium Royle fruit extract mitigates oxi-inflammatory stress by suppressing NF-κB/MAPK signalling cascade in activated macrophages and Treg proliferation in splenic lymphocytes.

Inflammopharmacology 2018 Dec 6. Epub 2018 Dec 6.

Pharmacology and Toxicology Lab, Food and Nutraceutical Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, HP, 176061, India.

Although Berberis plant species have been advocated as immune modulators, information regarding their mechanism(s) of action is limited. Therefore, in the present study we assessed the efficacy of Berberis lycium Royle fruit extract (BLFE) in the attenuation of lipopolysaccharide (LPS)-induced oxi-inflammatory aggravation and concanavalin A (Con-A)-induced proliferation in murine peritoneal macrophages and lymphocytes, respectively. BLFE strongly suppressed production of the oxidative and inflammatory effector molecules nitric oxide (NO), reactive oxygen species (ROS), inducible nitric oxide synthase (iNOS), inflammatory cytokines (TNF-α/IL-6/IL-1β/IFN-γ) as well as chemokines (MCP-1 and RANTES), with a concomitant enhancement in heme oxygenase-1 (HO-1) and IL-10 levels. Read More

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December 2018
5 Reads

Alpinia calcarata: potential source for the fabrication of bioactive silver nanoparticles.

Nano Converg 2018 Dec 6;5(1):37. Epub 2018 Dec 6.

Department of Botany, Bioresource Tech Laboratory, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, 495009, India.

In the present study silver nanoparticles fabricated by using leaf extract of Alpinia calcarata. We have also studied the effect of various experimental parameters viz., metal ion concentration, pH and incubation period on nanoparticle biosynthesis. Read More

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December 2018
2 Reads

Association of diabetes-related self-care activities with glycemic control of patients with type 2 diabetes in Pakistan.

Patient Prefer Adherence 2018 9;12:2377-2385. Epub 2018 Nov 9.

School of Pharmacy, Monash University, Jalan Lagoon Selatan 45700, Selangor, Malaysia,

Objective: Association of various self-care activities on glycemic control of people with diabetes (PWD) in Pakistan is yet to be explored. The current study aimed to evaluate the association of various diabetes-related self-care activities with glycated hemoglobin (HbA1c) levels and to examine the predictive relationship of patients' demographic variables with their self-care activities.

Patients And Methods: A cross-sectional study was conducted on adult PWD (N=218) who were diagnosed with type 2 diabetes mellitus of at least 1 year duration. Read More

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November 2018

Off- and on-target effects of genome editing in mouse embryos.

J Reprod Dev 2018 Dec 6. Epub 2018 Dec 6.

Experimental Animal Division, RIKEN BioResource Research Center, Ibaraki 305-0074, Japan.

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based genome editing technology has enabled manipulation of the embryonic genome. Unbiased whole genome sequencing comparing parents to progeny has revealed that the rate of Cas9-induced mutagenesis in mouse embryos is indistinguishable from the background rate of de novo mutation. However, establishing the best practice to confirm on-target alleles of interest remains a challenge. Read More

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December 2018

Secondary metabolites from the fermented rice of the fungus Monascus purpureus and their bioactivities.

Nat Prod Res 2018 Dec 5:1-10. Epub 2018 Dec 5.

b Bioresource Collection and Research Center (BCRC) , Food Industry Research and Development Institute (FIRDI) , Hsinchu , Taiwan.

Phytochemical investigation of the EtOAc-soluble fraction of the ethanolic extract of a yellow mutant of the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) grown on rice resulted in the isolation of one new azaphilone derivative, monapurpureusone (1), one acetophenone metabolite isolated for the first time from natural source, monapurpureusin (2), along with four known compounds, TW94a (3), ergosterol (4), monascin (5), and ankaflavin (6). The structures and relative configurations of these compounds were elucidated by spectroscopic analyses, including 1D- and 2D-NMR spectroscopy and mass spectrometry, and by the comparison of their NMR data with those of related compounds. Some phytochemicals were evaluated for both anti-inflammatory activity through the measurement of nitric oxide (NO) production levels in lipopolysaccharide (LPS)-stimulated murine-derived macrophages RAW264. Read More

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December 2018
1 Read

Lichen-associated bacterium, a novel bioresource of polyhydroxyalkanoate (PHA) production and simultaneous degradation of naphthalene and anthracene.

J Microbiol Biotechnol 2018 Nov 16. Epub 2018 Nov 16.

Korean Lichen Research Institute, Sunchon National University, Suncheon, Republic of Korea.

Lichens are generally known as self-sufficient symbiotic life-form between fungus and algae/cyanobacteria, also provide shelter for a wide range of beneficial bacteria. Besides, bacterial derived biodegradable polyhydroxyalkanoate (PHA) is currently grabbing the attention of many researchers as a promising alternative of non-degradable plastics. This study was conducted to develop a new method of PHA production using unexplored lichen-associated bacteria, which can simultaneously degrade two ubiquitous industrial toxins, anthracene and naphthalene. Read More

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November 2018
1 Read

Eighty Years of Mycopathologia: A Retrospective Analysis of Progress Made in Understanding Human and Animal Fungal Pathogens.

Mycopathologia 2018 Nov 30. Epub 2018 Nov 30.

Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Mycopathologia was founded in 1938 to 'diffuse the understanding of fungal diseases in man and animals among mycologists.' This was an important mission considering that pathogenic fungi for humans and animals represent a tiny minority of the estimated 1.5-5 million fungal inhabitants on Earth. Read More

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November 2018
1 Read

Elucidating functions of DP1 and DP2 subunits from the Thermococcus kodakarensis family D DNA polymerase.

Extremophiles 2018 Nov 30. Epub 2018 Nov 30.

Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 819-0395, Japan.

DNA polymerase D (PolD), originally discovered in Pyrococcus furiosus, has no sequence homology with any other DNA polymerase family. Genes encoding PolD are found in most of archaea, except for those archaea in the Crenarchaeota phylum. PolD is composed of two proteins: DP1 and DP2. Read More

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November 2018
2 Reads

Eelgrass Sediment Microbiome as a Nitrous Oxide Sink in Brackish Lake Akkeshi, Japan.

Microbes Environ 2018 Dec 1. Epub 2018 Dec 1.

College of Bioresource Sciences, Nihon University.

Nitrous oxide (NO) is a powerful greenhouse gas; however, limited information is currently available on the microbiomes involved in its sink and source in seagrass meadow sediments. Using laboratory incubations, a quantitative PCR (qPCR) analysis of NO reductase (nosZ) and ammonia monooxygenase subunit A (amoA) genes, and a metagenome analysis based on the nosZ gene, we investigated the abundance of NO-reducing microorganisms and ammonia-oxidizing prokaryotes as well as the community compositions of NO-reducing microorganisms in in situ and cultivated sediments in the non-eelgrass and eelgrass zones of Lake Akkeshi, Japan. Laboratory incubations showed that NO was reduced by eelgrass sediments and emitted by non-eelgrass sediments. Read More

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December 2018

Tinea Corporis Due to Trichophyton erinacei Probably Transmitted from a Hedgehog.

Med Mycol J 2018 ;59(4):E77-E79

Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine.

A 26-year-old female homemaker presented with an approximately 2-month history of an erythematous lesion with agminated seropapules in the right popliteal fossa associated with scales and crusts. The lesion was initially treated as contact dermatitis, but there was no improvement. KOH examination revealed filamentous fungi. Read More

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January 2018
3 Reads

A novel strategy for isolation and purification of fucoxanthinol and fucoxanthin from the diatom Nitzschia laevis.

Food Chem 2019 Mar 2;277:566-572. Epub 2018 Nov 2.

BIC-ESAT, College of Engineering, Peking University, Beijing 100871, China; Institute for Food and Bioresource Engineering, College of Engineering, Peking University, Beijing 100871, China. Electronic address:

In this study, the microalga Nitzschia laevis (N. laevis) can accumulate a marine carotenoid fucoxanthinol. In particular, fucoxanthinol was firstly isolated from microalgae, accompanied by its derivative fucoxanthin. Read More

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March 2019
2 Reads
3.391 Impact Factor

Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling.

Front Plant Sci 2018 20;9:1697. Epub 2018 Nov 20.

Department of Biochemistry, University of Missouri, Columbia, MO, United States.

Mitogen-Activated Protein Kinase (MAPK) cascades are conserved signaling modules that integrate multiple signaling pathways. One level of control on the activity of MAPKs is through their negative regulators, MAPK phosphatases (MKPs). Therefore, MKPs also play an integrative role for plants responding to diverse environmental stimulus; but the mechanism(s) by which these phosphatases contribute to specific signals remains largely unknown. Read More

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November 2018

Author Correction: Identifying long-term stable refugia for relict plant species in East Asia.

Nat Commun 2018 12 4;9(1):5241. Epub 2018 Dec 4.

Botanic Institute of Barcelona (IBB, CSIC-ICUB), Passeig del Migdia s/n, 08038, Barcelona, Catalonia, Spain.

In the original version of this Article, an incorrect sample size was provided for the number of relict species (443 instead of 442) and the number of relict forests (423 instead of 422). These errors have been corrected in both the PDF and HTML versions of the Article. Read More

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December 2018
3 Reads
10.742 Impact Factor

Styryl-Cinnamate Hybrid Inhibits Glioma by Alleviating Translation, Bioenergetics and Other Key Cellular Responses Leading to Apoptosis.

Exp Cell Res 2018 Dec 1. Epub 2018 Dec 1.

Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur-176061 (H.P.), India; Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow- 226031 (U.P.), India. Electronic address:

Gliomas are lethal and aggressive form of brain tumors with resistance to conventional radiation and cytotoxic chemotherapies; inviting continuous efforts for drug discovery and drug delivery. Interestingly, small molecule hybrids are one such pharmacophore that continues to capture interest owing to their pluripotent medicinal effects. Accordingly, we earlier reported synthesis of potent Styryl-cinnamate hybrids (analogues of Salvianolic acid F) along with its plausible mode of action (MOA). Read More

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December 2018
1 Read

A new aliphatic ester of hydroxysalicylic acid from fermented Carica papaya L. preparation with a potential hair growth stimulating activity.

Nat Prod Res 2018 Dec 4:1-6. Epub 2018 Dec 4.

a Division of Systematic Forest and Forest Products Sciences, Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences , Kyushu University , Fukuoka , Japan.

An aliphatic ester of hydroxysalicylic acid (6), reported for the first time from a natural source in addition to five known compounds were isolated from the fermented Carica papaya L. preparation, a commercialized functional food. The known compounds were identified as 5-hydroxymethylfurfuraldehyde (1), trans-caffeic acid (2), butyl 4-hydroxybenzoate (butylparaben) (3), lycopene (4), benzyl isothiocyanate (5). Read More

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December 2018

An apple transcription factor, MdDREB76, confers salt and drought tolerance in transgenic tobacco by activating the expression of stress-responsive genes.

Plant Cell Rep 2018 Dec 3. Epub 2018 Dec 3.

Department of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur, 176 061, India.

Key Message: An apple gene, MdDREB76 encodes a functional transcription factor and imparts salinity and drought stress endurance to transgenic tobacco by activating expression of stress-responsive genes. The dehydration-responsive element (DRE)-binding protein (DREB) transcription factors are well known to be involved in regulating abiotic stress-mediated gene expression in plants. In this study, MdDREB76 gene was isolated from apple (Malus x domestica), which encodes a functional transcription factor protein. Read More

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December 2018
1 Read

Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort.

Alzheimers Dement (N Y) 2018 26;4:645-651. Epub 2018 Nov 26.

Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan.

Introduction: The objective of this study was to determine the frequency and clinical and cognitive characteristics of preclinical Alzheimer's disease (AD) in a Japanese population to effectively design and conduct future preventive trials on preclinical AD.

Methods: Three-year longitudinal data from cognitively normal participants who underwent cerebrospinal fluid biomarker measurement and/or amyloid positron emission tomography in the Japanese Alzheimer's Disease Neuroimaging Initiative, were analyzed. Comparisons between participants with and without amyloid β (Aβ) accumulation, and between those with and without elevated tau levels tau among participants with Aβ accumulation were performed. Read More

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November 2018
3 Reads

Anticancer, antimicrobial and antioxidant potential of sterically tuned bis-N-heterocyclic salts.

Z Naturforsch C 2018 Nov 30. Epub 2018 Nov 30.

Department of Pharmacy, COMSATS University, Abbotabad 22060, Pakistan, Phone: +92-992-383591.

The current study was conducted to evaluate the antimicrobial, antioxidant, antileishmanial and cytotoxic potential of designed derivatives of 1,1'-(1,3-phenylenebis(methylene))bis(3-alkyl/aryl-1H-benzimidazol-3-ium) salts. The antibacterial potential of the test compounds was investigated against Staphylococcus aureus, Pseudomonas aeruginosa and two methicillin-resistant S. aureus (MRSA) strains (MRSA10, MRSA11), where compound 6 showed the best results. Read More

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November 2018
3 Reads

Phytochemical studies of Jurinea macrocephala roots from Western Himalaya.

Nat Prod Res 2018 Nov 30:1-4. Epub 2018 Nov 30.

a Academy of Scientific and Innovative Research, CSIR- Institute of Himalayan Bioresource Technology , Palampur , Himachal Pradesh , India.

Phytochemical investigation of the Jurinea macrocephala roots afforded six compounds namely β-sitosterol (1), lupenone (2), physcion (3), ptiloepoxide (4), 20, 21α-epoxytaraxastan-3β-ol (5) and chlorogenic acid (6). All the compounds were isolated for the first time in roots. The structures of the compounds were established by analysis of their spectroscopic (H and C NMR) and spectrometric (MS) data, as well as by comparison of these with those reported in the literature. Read More

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November 2018

Genome and Transcriptome Sequencing of the Astaxanthin-Producing Green Microalga, Haematococcus pluvialis.

Genome Biol Evol 2018 Nov 29. Epub 2018 Nov 29.

Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Key Laboratory of Plant Epigenetic, Shenzhen Key Laboratory of Marine Bioresource & Eco-environmental Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, China.

Haematococcus pluvialis is a freshwater species of Chlorophyta, family Haematococcaceae. It is well known for its capacity to synthesize high amounts of astaxanthin, which is a strong antioxidant that has been utilized in aquaculture and cosmetics. To improve astaxanthin yield and to establish genetic resources for H. Read More

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November 2018

Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages.

PLoS Pathog 2018 Nov 29;14(11):e1007372. Epub 2018 Nov 29.

Center for AIDS Research, Kumamoto University, Kumamoto, Japan.

Apolipoprotein E (ApoE) belongs to a class of cellular proteins involved in lipid metabolism. ApoE is a polymorphic protein produced primarily in macrophages and astrocytes. Different isoforms of ApoE have been associated with susceptibility to various diseases including Alzheimer's and cardiovascular diseases. Read More

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November 2018
1 Read

Toxicity Concerns of Therapeutic Nanomaterials.

J Nanosci Nanotechnol 2019 Apr;19(4):1889-1907

Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061 (H.P.), India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061 (H.P.), India.

In the modern era, research on the synthesis of nanoparticles (NPs) has been growing exponentially. Due to their small size together with extra-ordinary physico-chemical properties, a variety of NPs i.e. Read More

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Soil Bacteria Isolated From Tunisian Arid Areas Show Promising Antimicrobial Activities Against Gram-Negatives.

Front Microbiol 2018 13;9:2742. Epub 2018 Nov 13.

Laboratory of Plant Improvement and Valorization of Agroresources, National School of Engineering of Sfax, Sfax, Tunisia.

Arid regions show relatively fewer species in comparison to better-watered biomes, but the competition for the few nutrients is very distinct. Here, in total 373 bacterial strains were isolated from rhizospheric soils obtained from three different sampling sites in Tunisia. Their potential for the production of antimicrobial compounds was evaluated. Read More

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November 2018

Medaka Population Genome Structure and Demographic History Described via Genotyping-by-Sequencing.

G3 (Bethesda) 2018 Nov 27. Epub 2018 Nov 27.

Kitasato University School of Medicine.

Medaka is a model organism in medicine, genetics, developmental biology and population genetics. Lab stocks composed of more than 100 local wild populations are available for research in these fields. Thus, medaka represents a potentially excellent bioresource for screening disease-risk- and adaptation-related genes in genome-wide association studies. Read More

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November 2018

Kinetic modeling and sensitivity analysis for higher ethanol production in self-cloning xylose-using Saccharomyces cerevisiae.

J Biosci Bioeng 2018 Nov 24. Epub 2018 Nov 24.

Laboratory of Synthetic Biology, Graduate School of Systems Life Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:

We constructed a xylose-utilizing Saccharomyces cerevisiae strain using endogenous xylose-assimilating genes (strain K7-XYL). Such self-cloning yeast is expected to make a great contribution to cost reduction of ethanol production processes. However, it is difficult to modify self-cloning yeast for optimal performance because the available gene source is limited. Read More

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November 2018
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Highly self-diffused Sn doping in α-FeO nanorod photoanodes initiated from β-FeOOH nanorod/FTO by hydrogen treatment for solar water oxidation.

Nanoscale 2018 Dec 27;10(47):22560-22571. Epub 2018 Nov 27.

Division of Biotechnology, Safety, Environment and Life Science Institute, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 570-752, Republic of Korea.

In this study, we present an advanced strategy of low-temperature hydrogen annealing combined with high- temperature quenching in air for activating α-FeO nanorod photoanodes to boost the photoelectrochemical performance. We report that various low-temperature annealing conditions (340, 360, 380, and 400 °C) under hydrogen gas flow convert β-FeOOH into magnetite (FeO) as well as introduce Sn diffusion from FTO substrates to its surface. Furthermore, high-temperature quenching (800 °C) resulted in the phase change of magnetite (FeO) into hematite (α-FeO) and self Sn doping into the hematite lattice. Read More

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December 2018
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7.394 Impact Factor

Extract of the Microalga Nitzschia laevis Prevents High-Fat-Diet Induced Obesity in Mice by Modulating the Composition of Gut Microbiota.

Mol Nutr Food Res 2018 Nov 26:e1800808. Epub 2018 Nov 26.

Institute for Food and Bioresource Engineering, College of Engineering, Peking University, Beijing, 100871, China.

Scope: The aim of the present study is to investigate the efficacy of Nitzschia laevis extract (NLE) in preventing obesity in mice fed with a high-fat diet (HFD), and the potential underlying mechanisms focusing on modulation of the gut microbiota profile.

Methods And Results: Physiological, histological, and biochemical parameters and gut microbiota compositions are compared among four experimental groups fed respectively with the following diets for 8 weeks: Normal chow diet, HFD, HFD + low concentration of NLE, and HFD + high concentration of NLE. The results demonstrate that NLE supplementation significantly reduces body weight gain and effectively prevents lipid accumulation in the white adipose tissue and liver of the mice. Read More

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November 2018
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Plastidial starch phosphorylase is highly associated with starch accumulation process in developing squash (Cucurbita sp.) fruit.

Physiol Plant 2018 Nov 25. Epub 2018 Nov 25.

College of Bioresource Sciences, Nihon University, Kameino Fujisawa, 252-0880, Japan.

We investigated changes in starch content and starch metabolic enzyme activities in developing and postharvest squash of distinct species, Cucurbita maxima and C. moschata, which accumulate high and low levels of starch, respectively. The total activity of starch phosphorylase in developing fruits significantly correlated (r = 0. Read More

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November 2018
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Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2.

Neuropsychopharmacol Rep 2018 Nov 24. Epub 2018 Nov 24.

Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

Aim: Tryptophan hydroxylase 2 (Tph2) is a rate-limiting enzyme for the biosynthesis of 5-hydroxytryptamine (5-HT, serotonin). Previous studies have reported that C1473G polymorphism of the murine Tph2 gene leads to decreased 5-HT levels in the brain and abnormal behavioral phenotypes, such as impaired anxiety- and depression-like behaviors. In this study, to confirm the effect of the C1473G polymorphism on mouse phenotypes, we conducted a comprehensive battery of behavioral tests and measured the amounts of brain free amino acids involved in the production of 5-HT. Read More

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November 2018
6 Reads