Search Our Scientific Publications & Authors

Rheumatology (Oxford) 2020 Jun 28. Epub 2020 Jun 28.

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Objectives: To identify dysregulated microRNAs (miRNAs) and their gene targets in temporal arteries from GCA patients, and determine their association with GCA pathogenesis and related arterial wall remodelling.

Methods: We included 93 formalin-fixed, paraffin-embedded temporal artery biopsies (TABs) from treatment-naïve patients: 54 positive and 17 negative TABs from clinically proven GCA patients, and 22 negative TABs from non-GCA patients. miRNA expression analysis was performed with miRCURY LNA miRNome Human PCR Panels and quantitative real-time PCR. Read More

BMJ Case Rep 2020 Jun 21;13(6). Epub 2020 Jun 21.

Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

A 77-year-old man visited the hospital with a chronic cough persisting for 2.5 months accompanied with night sweats, weight loss (3.5 kg) and elevated C-reactive protein level. Read More

Ann Vasc Surg 2020 Jun 15. Epub 2020 Jun 15.

The Ohio State University.

Introduction: Temporal arteritis (TA) is a systemic inflammatory vasculitis of unclear etiology that affects medium sized vessels. The gold standard for diagnosis has traditionally been histological, by temporal artery biopsy. Improved imaging modalities have been increasingly used to aid diagnosis and are recommended in the newest 2018 European (EULAR) Guidelines. Read More

Radiology 2020 Jul;296(1):239-243

From the School of Medicine (P.A.) and Departments of Neurosciences (K.L., P.C., B.H.) and Radiology (J.H.), University of California San Diego Medical Center, 200 West Arbor Dr, San Diego, CA 92103.

HistoryA 25-year-old woman with recently diagnosed systemic lupus erythematosus and class IV lupus nephritis confirmed with biopsy and treated with mycophenolate mofetil presented with a 2-day history of progressively worsening edema of her face and lower extremities. She had no antecedent infection or vaccination. She was admitted to the hospital and treated with methylprednisolone, furosemide, and C1 esterase inhibitor. Read More

BMC Vet Res 2020 Jun 5;16(1):177. Epub 2020 Jun 5.

Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Foundation, Hannover, Germany.

Background: In dogs, meningiomas mostly cause chronic progressive clinical signs due to slow tumor growth.

Case Presentation: In contrast, three dogs were presented with the history of chronic generalized tonic-clonic seizures and peracute deterioration with sudden onset of neurological deficits in accordance with an extensive unilateral forebrain lesion. Magnetic resonance imaging examinations of the dogs revealed a well-delineated extraaxial T2W hyperintense mass in the rostral forebrain with homogeneous contrast enhancement. Read More

Semin Arthritis Rheum 2020 Jun 1;50(4):616-623. Epub 2020 Jun 1.

Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. Electronic address:

Background And Aim: Assessing cranial artery inflammation plays an important role in the diagnosis of cranial giant cell arteritis (C-GCA). However, current diagnostic tests are limited. The use of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT imaging is an established tool for assessing large vessel inflammation but is currently not used for assessment of the cranial arteries. Read More

Aging Dis 2020 May 9;11(3):603-617. Epub 2020 May 9.

1Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, China.

The complex pathology of chronic thoracic spinal cord compression involves vascular and neuroarchitectural repair processes that are still largely unknown. In this study, we used synchrotron radiation microtomography (SRμCT) to quantitatively characterize the 3D temporal-spatial changes in the vascular and neuronal network after chronic thoracic spinal cord compression in order to obtain further insights into the pathogenesis of this disease and to elucidate its underlying mechanisms. Direct 3D characterization of the spinal cord microvasculature and neural microstructure of the thoracic spinal cord was successfully reconstructed. Read More

Clin Rheumatol 2020 May 29. Epub 2020 May 29.

Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHULN, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Giant cell arteritis (GCA) is a granulomatous vasculitis involving large- and middle-sized arteries, with a predilection for cranial arteries. In this paper, we aim to describe a case of a biopsy- and ultrasound-proven GCA, presenting with anterior ischemic optic neuropathy (AION) and normal CRP and ESR at diagnosis and during follow-up, and to review the literature on GCA cases with low inflammatory markers, with a particular focus on the presence of eye involvement. Both CRP and ESR are important in the diagnosis of GCA; occurrence of this disease with normal acute phase reactants is unusual but does not rule out the diagnosis. Read More

J Neuroophthalmol 2020 Apr 16. Epub 2020 Apr 16.

Wilmer Eye Institute (OMS, RF, ADH), Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology (MAV), Division of Neuro-Ophthalmology (ADH, OMS); Division of Oculoplastics (RF), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Department of Pathology, Mayo Clinic, Rochester, Minnesota.

We present a case of vision loss secondary to neurosarcoidosis, which initially presented with severe bilateral vision loss, temporal headaches, and elevated erythrocyte sedimentation rate, concerning for giant cell arteritis. However, temporal artery biopsy was negative. Initial neuroimaging features were misinterpreted to represent a meningioma that did not account for his clinical presentation. Read More

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):112-119. Epub 2020 May 21.

Departments of Rheumatology, Internal Medicine and Pathology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain.

Objectives: A potential point of concern among clinicians is whether results derived from the clinical trials can be reasonably applied or generalised to a definable group of patients seen in real world. It can be the case of the GiACTA study that is a phase III randomised controlled trial of tocilizumab (TCZ) in giant cell arteritis (GCA). To address this question, we compared the clinical features and the responses to TCZ from the GiACTA trial patients with those from a series of GCA seen in the daily clinical practice. Read More

BMC Med Imaging 2020 May 21;20(1):54. Epub 2020 May 21.

Department of Cardiology, the first hospital of Lanzhou University, Lanzhou, 730000, China.

An amendment to this paper has been published and can be accessed via the original article. Read More

Cureus 2020 Apr 17;12(4):e7704. Epub 2020 Apr 17.

Malignant Hematology & Cellular Therapy, Moffitt Cancer Center at Memorial Healthcare System, Pembroke Pines, USA.

We present a case of a 59 year old female patient that presented with exertional chest pain and palpitations. A workup revealed an EKG with signs of right ventricular hypertrophy, a high Pro-BNP and 3 sets of negative troponin levels. A CT scan of the chest was negative for pulmonary embolism (PE) but revealed a nodular thickening of the atrial septum with right atrial extension encasing the right coronary artery. Read More

Minerva Pediatr 2020 May 15. Epub 2020 May 15.

Department of Pediatrics, Dr D. Y. Patil Hospital and Research Centre and D. Y. Patil Medical College, D.Y. Patil Education Society (Deemed-to-be-University), Kolhapur, Maharashtra, India.

Background: Accurate temperature measurement with little or no discomfort that is safe, without risk of hospital-acquired infections or perforations, is the preferred choice of medical professionals in pediatric settings. The objective was to discover the preferable site for body temperature measurement using non-contact infra-red thermometer (NCIT) among pediatric patients.

Methods: NCIT measurement at mid forehead (F), right temporal region (T), right side of neck- over-carotid artery area (N), jugular notch (J), sternum (S), umbilical region and sublingual region (U) were compared with digital axillary temperature (DAT) in a single attempt in 500 patients, aged between 2 to 5 years with fever. Read More

J Neurosurg 2020 May 15:1-10. Epub 2020 May 15.

1Neuroimaging Laboratory (LNI), Department of Neurology.

Objective: The objective of this study was to evaluate the efficacy and safety of a modified surgical approach for the treatment of temporal lobe epilepsy secondary to hippocampal sclerosis (HS). This modified approach, called temporopolar amygdalohippocampectomy (TP-AH), includes a transsylvian resection of the temporal pole and subsequent amygdalohippocampectomy utilizing the limen insula as an anatomical landmark.

Methods: A total of 61 patients who were diagnosed with HS and underwent TP-AH between 2013 and 2017 were enrolled. Read More

Neuroophthalmology 2020 Jun 9;44(3):174-181. Epub 2019 Oct 9.

Department of Ophthalmology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

To determine whether temporal artery biopsy (TABx) or Doppler ultrasound (US) of the temporal artery is the preferred confirmatory test for giant cell arteritis, an online survey of ophthalmologists and neurologists in North America, Europe and Israel was conducted in 2019; Canadian rheumatologists were also included. There were 406 survey participants with an estimated survey response rate of 18%. Ninety-four per cent of North American practitioners preferred TABx compared with 74% of their European counterparts. Read More

Eur J Radiol 2020 Jul 19;128:109017. Epub 2020 Apr 19.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Dadao 1095(#), Wuhan 430030, PR China. Electronic address:

Purpose: To analyse the high-resolution computed tomography (HRCT) early imaging features and the changing trend of coronavirus disease 2019 (COVID-19) pneumonia.

Materials And Methods: Forty-six patients with COVID-19 pneumonia who had an isolated lesion on the first positive CT were enrolled in this study. The following parameters were recorded for each lesion: sites, sizes, location (peripheral or central), attenuation (ground-glass opacity or consolidation), and other abnormalities (supply pulmonary artery dilation, air bronchogram, interstitial thickening, etc. Read More

Cardiovasc Revasc Med 2020 Apr 29. Epub 2020 Apr 29.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States of America. Electronic address:

Background: The advent of transcatheter aortic valve replacement (TAVR) has changed which patients undergo surgical aortic valve replacement (SAVR). We sought to understand the impact of TAVR on the characteristics of SAVR patients in the United States.

Methods: A cohort of 2959 patients who underwent isolated SAVR at 11 US hospitals that perform both TAVR and SAVR from 2013 through 2017 were grouped by the Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database version (v)2. Read More

J Med Case Rep 2020 May 10;14(1):57. Epub 2020 May 10.

Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.

Background: Given the absence of consensus diagnostic criteria for giant cell arteritis, clinicians may encounter difficulty with identification of new-onset headache in patients older than age 50 years presenting with visual changes and elevated inflammatory markers, particularly if temporal artery biopsies are performed and negative.

Case Presentation: We present a case of a 57-year-old white man with headache, diplopia, and jaw paresthesia initially diagnosed and managed as steroid-refractory biopsy-negative giant cell arteritis. Further investigation disclosed evidence of soft tissue infiltration into Meckel's (trigeminal) cave bilaterally. Read More

Neurologist 2020 May;25(3):70-72

Department of Neurology, Mayo Clinic, Scottsdale, AZ.

Introduction: Older adults presenting with a new or changed headache pattern in the setting of a diagnosis of polymyalgia rheumatica (PMR) are at risk for incident giant cell arteritis. However, the differential diagnosis of headache has not been evaluated in patients with a negative temporal artery biopsy (TAB). Headache has not been described as a symptom of PMR. Read More

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii5-iii16

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

GCA is the most common form of primary systemic vasculitis affecting older people. It is considered a clinical emergency because it can lead to irreversible blindness in around 20% of untreated cases. High doses of glucocorticoids should be initiated promptly to prevent disease-related complications; however, glucocorticoids therapy usually results in significant toxicity. Read More

J Cereb Blood Flow Metab 2020 Apr 28:271678X20921974. Epub 2020 Apr 28.

Neurological Surgery, Washington University School of Medicine, , Saint Louis, MO, USA.

Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) has been associated with numerous pathophysiological sequelae, including large artery vasospasm and microvascular thrombosis. The focus of this review is to provide an overview of experimental animal model studies and human autopsy studies that explore the temporal-spatial characterization and mechanism of microvascular platelet aggregation and thrombosis following SAH, as well as to critically assess experimental studies and clinical trials highlighting preventative therapeutic options against this highly morbid pathophysiological process. Upon review of the literature, we discovered that microvascular platelet aggregation and thrombosis occur after experimental SAH across multiple species and SAH induction techniques in a similar time frame to other components of DCI, occurring in the cerebral cortex and hippocampus across both hemispheres. Read More

J Clin Rheumatol 2020 Apr 23. Epub 2020 Apr 23.

From the Division of Rheumatology, Allergy, and Immunology, Stony Brook University, Stony Brook, NY.

Medicine (Baltimore) 2020 Apr;99(16):e19835

Department of Physical Therapy, College of Health Sciences, Dankook University.

Rationale: Pusher syndrome is a disorder of postural control. It is associated with unilateral lesions on central vestibular system. In the current study, we attempted to identify and investigate neural connectivity of the parieto-insular vestibular cortex in a patient with pusher syndrome, using diffusion tensor imaging. Read More

J Ophthalmic Vis Res 2020 Apr-Jun;15(2):201-209. Epub 2020 Apr 6.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To assess the use of temporal artery biopsy (TAB) in diagnosing giant cell arteritis (GCA) and to evaluate patients' clinical and laboratory characteristics.

Methods: We conducted a retrospective chart review of patients with suspected GCA who underwent TAB and had complete workup in a tertiary center in Iran between 2008 and 2017. The 2016 American College of Rheumatology (ACR) revised criteria for early diagnosis of GCA were used for each patient for inclusion in this study. Read More

Ann Diagn Pathol 2020 Apr 8;46:151517. Epub 2020 Apr 8.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, OH 44195, USA. Electronic address:

Giant cell arteritis is a vasculitis that affects large- and medium-sized vessels in patients over the age of 50 years. The demonstration of granulomatous arteritis is the criterion standard to establish a definitive diagnosis. However, temporal arteritis is known to discontinuously involve the artery, and there is no standardization of the number of sections which should be examined in a length of sampled artery. Read More

Am J Cardiol 2020 Jun 2;125(12):1879-1883. Epub 2020 Apr 2.

Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

Tricuspid valve disease (TVD), particularly tricuspid regurgitation, is a common valvular pathology that is associated with increased morbidity and mortality. The prevalence of TVD in hospitalized patients has not been well characterized. We used the National Inpatient Sample to determine the overall and age- and sex-specific prevalence and temporal trends in prevalence of TVD in hospitalized patients in the US. Read More

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):95-98. Epub 2020 Apr 4.

Université Paris Descartes, and Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Systémiques Rares, Hôpital Cochin, AP-HP, Paris, France.

Objectives: Imaging techniques have an increasing place in the diagnosis of giant cell arteritis (GCA). Achieving a confident diagnosis of GCA is often challenging and temporal artery biopsy is still considered as the gold standard despite the delayed results. 3T-MRI with 2D sequences has been evaluated for the detection of mural inflammation in extracranial arteries to support the diagnosis of GCA. Read More

Neuropsychiatr Dis Treat 2020 23;16:789-800. Epub 2020 Mar 23.

Department of Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541004, People's Republic of China.

Purpose: Excitatory amino acid transporters (EAATs) have an indispensable function in the reuptake of extracellular glutamate. To investigate the relationship and the expression of neuronal and astrocytic markers after brain ischemia, the temporal profile of glial EAATs in both peripheral and core regions of the cortex was examined.

Methods: Transient common carotid artery occlusion was used to induce unilateral transient forebrain ischemia of Mongolian gerbils, and post-ischemic brains (6 h to 2 w) were collected and prepared for immunohistochemical and Western blotting analysis of glutamine synthetase (GS), GLT-1, GLAST, S100β, and NeuN, and for Alizarin red staining of calcium deposits. Read More

Prenat Diagn 2020 Jun 17;40(7):892-904. Epub 2020 May 17.

Division of Obstetric Ultrasonography, Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, P.R. China.

Objectives: Establish a fetal heart anatomical cross-sectional database that correlates with screening transverse ultrasound images suggested by international professional organizations to detect congenital heart defects.

Methods: Fetuses with suspected congenital heart defects identified using the following cardiac image sequences obtained from transverse slices beginning from the upper abdomen and ending in the upper thorax were the subjects of this study: (1) four-chamber view, (2) left ventricular outflow tract view, (3) three-vessel right ventricular outflow tract view, and (4) the three-vessel tracheal view. A database of digital two-dimensional images of the transverse sweep was created for fetuses with confirmed congenital heart defects. Read More

Case Rep Nephrol 2020 26;2020:1426401. Epub 2020 Mar 26.

Penn Medicine Princeton Medical Center, Princeton Hypertension and Nephrology, 1 Plainsboro Rd, Plainsboro Township, NJ 08536, USA.

Microscopic polyangiitis (MPA) is an idiopathic autoimmune disease characterized by systemic vasculitis. While the lungs and kidneys are the major organs affected by MPA, it is known to involve multiple organ systems throughout the body. Temporal artery involvement is a very rare finding in MPA. Read More

Arthritis Res Ther 2020 04 7;22(1):72. Epub 2020 Apr 7.

Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes is important to decide the treatment algorithm of GCA.

Methods: We enrolled 139 newly diagnosed GCA patients treated with glucocorticoids between 2007 and 2014 in a retrospective, multi-center registry. Read More

Sci Rep 2020 Apr 3;10(1):5877. Epub 2020 Apr 3.

Department of Surgical Sciences, Section of Otolaryngology, Uppsala University Hospital, SE, 751 85, Uppsala, Sweden.

Human spiral ganglion (HSG) cell bodies located in the bony cochlea depend on a rich vascular supply to maintain excitability. These neurons are targeted by cochlear implantation (CI) to treat deafness, and their viability is critical to ensure successful clinical outcomes. The blood supply of the HSG is difficult to study due to its helical structure and encasement in hard bone. Read More

Zhonghua Shao Shang Za Zhi 2020 Mar;36(3):219-223

Department of Burns and Cutaneous Surgery, Burn Center of PLA, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.

To evaluate the clinical effects of anterolateral thigh free flap with fascia lata in the repair of dura mater defect after resection of head squamous cell carcinoma. From June 2016 to June 2018, Xijing Hospital of Air Force Medical University applied the free transplantation of anterolateral thigh flap with fascia lata to repair the dura mater defect of 12 patients with head squamous cell carcinoma, including 9 males and 3 females, aged from 35 to 74 years. The size of scalp soft tissue defects in patients after carcinoma resection ranged from 12 cm×10 cm to 24 cm×21 cm, and the size of dura mater defect of patients ranged from 7 cm×6 cm to 16 cm×14 cm. Read More

Rev Fac Cien Med Univ Nac Cordoba 2020 03 12;77(1):4-9. Epub 2020 Mar 12.

Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno".

Introduction: Giant cell arteritis (GCA) is the most frequent systemic vasculitis in patients older than 50 years. The diagnosis is based on the clinical history, laboratory findings and imaging studies associated with a temporal artery biopsy (TAB). However, the biopsy result could be inconclusive in up to 40% of the cases. Read More

J Craniofac Surg 2020 Mar 27. Epub 2020 Mar 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Daegu Fatima Hospital, Daegu, South Korea.

A pseudoaneurysm is an uncommon pathology arising from any artery in the human body. It typically presents as a pulsatile swelling in contact with a blood vessel. Of pseudoaneurysms of the head and neck region, the most common site is the superficial temporal artery while that of the dorsal nasal artery is extremely rare. Read More

BMJ Case Rep 2020 Mar 25;13(3). Epub 2020 Mar 25.

Internal Medicine, Hospital Santo António dos Capuchos, Lisboa, Portugal.

A 60-year-old man was hospitalised with persistent fever, arm pain, dry cough and cholestasis. Diagnostic workup was remarkable for elevated inflammatory markers. Infectious diseases and autoimmune screening were negative. Read More

World J Gastroenterol 2020 Mar;26(9):960-972

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Background: In clinical practice, the diagnosis is sometimes difficult with contrast-enhanced ultrasound (CEUS) when the case has an atypical perfusion pattern. Color parametric imaging (CPI) is an analysis software for CEUS with better detection of temporal differences in CEUS imaging using arbitrary colors. It measures the differences in arrival time of the contrast agent in lesions so that the perfusion features of atypical hemangioma and colorectal cancer (CRC) liver metastasis can be distinguished. Read More

J Am Coll Cardiol 2020 May 16;75(17):2156-2165. Epub 2020 Mar 16.

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: E-selectin and intercellular adhesion molecule (ICAM)-1 are biomarkers of endothelial activation, which has been implicated in the pathogenesis of heart failure (HF) with preserved ejection fraction (HFpEF). However, the temporal associations between E-selectin and ICAM-1 with subclinical cardiac dysfunction are unclear.

Objectives: This study sought to assess the longitudinal associations of E-selectin and ICAM-1 with subclinical alterations in cardiac function. Read More

Radiol Med 2020 Mar 19. Epub 2020 Mar 19.

University of Toronto, Toronto, Canada.

Temporal artery biopsy (TAB) is frequently still required in patients with suspected cranial giant cell arteritis (GCA). The literature on the performance characteristics of TAB versus imaging is conflicting, and several meta-analyses suggest that TAB is more sensitive than ultrasound. False-positive ultrasound results can occur. Read More

Clin Med (Lond) 2020 Mar;20(2):224-226

Great Western Hospital, Swindon, UK.

Giant cell arteritis (GCA) is an important condition to suspect and treat early, as failure to do so can result in anterior ischaemic optic neuropathy and subsequent permanent visual loss.A 71-year-old woman presented to her local emergency department with a 1-week history of constant, moderate-severe global headache associated with intermittent periorbital pain. Two weeks later she developed sudden horizontal diplopia. Read More

Curr Opin Rheumatol 2020 May;32(3):201-207

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Giant cell arteritis (GCA) has classically been diagnosed by temporal artery biopsy and treated with high-dose, long-term glucocorticoid therapy. Noninvasive imaging increasingly is employed for diagnostic purposes, but further studies are needed to determine the role of imaging in monitoring longitudinal disease activity. Glucocorticoid-sparing therapy mitigates the numerous adverse effects of glucocorticoids. Read More

Skinmed 2020 1;18(1):54-55. Epub 2020 Jan 1.

Oakland University William Beaumont School of Medicine, Royal Oak, MI.

A 79-year-old woman presented to the emergency room with a chief complaint of headache of 1 month's duration. Her medical history consisted of hypertension, congestive heart failure, anemia, chronic kidney disease, and hyperlipidemia. She reported the headache as waxing and waning, and occurring bilaterally in the frontal and occipital regions. Read More

Age Ageing 2020 Apr;49(3):487-489

Département de Gériatrie, APHP, Hôpital Bichat, 75018 Paris, France.

A 70-year-old patient was admitted with rapidly progressive cognitive decline associated with limitations in activities of daily living, weight loss and cerebellar ataxia. The diagnosis of giant cell arteritis (GCA) with vascular involvement was made, based on the presence of a metabolically active vasculitis of the brachiocephalic trunk on 18FDG-PET imaging. Temporal artery biopsy also revealed pan-arteritis. Read More

Cureus 2020 Jan 29;12(1):e6814. Epub 2020 Jan 29.

Epidemiology and Public Health, Deakin University, Victoria, AUS.

Background Management of elderly patients with Non-ST Elevation Myocardial Infarction (NSTEMI) continues to be a source of controversy due to underrepresentation in large-scale clinical trials and the increased risk of adverse outcomes after both invasive (Percutaneous coronary intervention and Coronary artery bypass grafting) and non-invasive therapies. Recent randomized clinical trials have shown improved short term and intermediate term outcomes among high risk NSTEMI patients receiving early invasive management versus conservative medical management. However, how this is reflected in U. Read More

Intern Med 2020 May 26;59(10):1323-1330. Epub 2020 Feb 26.

Department of Rheumatology, Tokyo Medical University Hospital, Japan.

We describe a case of eosinophilic temporal arteritis in a 61-year-old woman with hypereosinophilic syndrome, who developed subcutaneous nodules in the temporal areas and digital cyanosis with small nodules on the sides of her fingers. Ultrasound revealed occlusion and corkscrew-like changes of the temporal and digital arteries, respectively. Temporal artery biopsy revealed eosinophilic vasculitis without giant cell formation. Read More

Am J Ophthalmol Case Rep 2020 Mar 1;17:100583. Epub 2020 Jan 1.

Tennessee Retina, 345 23rd Ave N, Ste 350, Nashville, TN, 37203, USA.

Purpose: Herein we present a case of giant cell arteritis presenting with nodular posterior scleritis and exudative retinal detachment mimicking a choroidal mass.

Observations: A 67-year-old man presented with sudden onset left-sided periorbital pain, blurry vision, and a choroidal lesion in the posterior pole. Despite treatment with high-dose oral prednisone for suspected nodular posterior scleritis mimicking a choroidal mass, the vision in his left eye did not recover, and he developed optic nerve pallor on exam. Read More

World Neurosurg 2020 May 19;137:341-344. Epub 2020 Feb 19.

Department of Neurosurgery, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan. Electronic address:

Background: Early and late images of I-iomazenil (I-IMZ) single-photon emission computed tomography (SPECT) are considered to show cerebral blood flow and neuronal activity, respectively, and this modality may demonstrate temporal dysfunction of the frontal lobes in obstructive hydrocephalus. In this report, we examined I-IMZ SPECT in a patient with chronic obstructive hydrocephalus owing to compression of the aqueduct by a partially thrombosed aneurysm of the left posterior cerebral artery for the first time.

Case Description: A woman aged 77 years presented with progression of cognitive decline, gait disturbance, and urinary incontinence. Read More

Int J Oral Maxillofac Surg 2020 Feb 15. Epub 2020 Feb 15.

Department of Head and Neck, Facial Surgery, Ohara General Hospital, Fukushima, Japan.

The objectives of this study were to evaluate survival in 141 patients with stage II-IV oral squamous cell carcinoma (OSCC) treated with preoperative intra-arterial chemotherapy with docetaxel, cisplatin, and peplomycin combined with intravenous chemotherapy using 5-fluorouracil (IADCPIVF) via the superficial temporal artery, and to clarify the prognostic factors. The study population included 59 patients with stage II OSCC, 34 with stage III, and 48 with stage IV. After IADCPIVF, 139 patients underwent surgery; minimally invasive surgeries (MIS) including excisional biopsy were performed on 96 patients with a remarkably good response to IADCPIVF. Read More

Singapore Dent J 2020 Feb 14:1-5. Epub 2020 Feb 14.

Department of Pathology, National University Hospital, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.

The superficial temporal artery (STA) is a structure that is particularly vulnerable to injury, given its prominent location in the head and neck region. Pseudoaneurysms of this artery may be encountered during the management of maxillofacial trauma. This article presents a review of the relevant literature on this topic. Read More

Acta Pharmacol Sin 2020 Jun 5;41(6):745-752. Epub 2020 Feb 5.

First Department of Surgery, Vascular Unit, Laiko General Hospital, National & Kapodistrian University of Athens, 11527, Athens, Greece.

Circulating or tissue-related biomarkers are of clinical value for risk stratification in patients with abdominal aortic aneurysms. Relaxin-2 (RL2) has been linked to the presence and size of arterial aneurysms, and to the extent of atherosclerosis in human subjects. Here, we assessed the expression levels of RL2 in aneurysmal (AA, n = 16) and atherosclerotic (ATH, n = 22) arteries, and established the correlation between RL2 levels and the presence/size of AA and the clinical severity of atherosclerosis. Read More