Search Our Scientific Publications & Authors

J Craniofac Surg 2020 May 28. Epub 2020 May 28.

Department of Adult and Development Age Human Pathology "Gaetano Barresi," Unit of Otorhinolaryngology, University of Messina, Messina, Italy.

Hairy polyps are histological benign lesions derived from 2 germinal layers which arise during fetal period, they can occur anywhere in the body. When they are localized in the oropharynx or nasopharynx can lead to upper airway obstruction in infants.We describe a case of a 2-days-old full-term female with intermittent upper airway obstruction, stridor, and feeding difficulty. Read More

Asian Pac J Cancer Prev 2020 May 1;21(5):1227-1234. Epub 2020 May 1.

Oral Oncology Center and Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.

Objective: This study aimed to evaluate the quality of life of patients with oral or oropharyngeal cancer by using specific questionnaires (QLQ-C30 and QLQ-HandN35), varying according to the location of the tumor (oral cavity or oropharynx) and the treatment performed (only surgery or surgery associated with radiotherapy).

Methods: Fifty patients were enrolled in this study and answered the EORTC QLQ-C30 and EORTC HandN35 questionnaires, before (baseline), at 1 week, and 3 months after treatment. Internal consistency reliability was calculated with the Cronbach coefficient. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 11. Epub 2020 May 11.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: The aim of the present study was to assess the prevalence of TERT promoter region mutations in tumor samples of patients with squamous cell carcinoma at different sites of the head and neck region and correlate it with patients' clinicopathologic data.

Study Design: Mutations in promoter region of the TERT gene were analyzed with polymerase chain reaction-based direct sequencing method using formalin-fixed, paraffin-embedded tumor samples of 189 HNSCCs. TERT promoter region mutations were assessed in terms of age, gender, location, smoking, alcohol consumption, and overall survival. Read More

Laryngoscope 2020 May 9. Epub 2020 May 9.

USC Caruso Department of Otolaryngology-Head and Neck Surgery, Los Angeles, California, U.S.A.

A rare complication of flap reconstruction following oncologic ablation is metastasis to the donor site. We present a novel case of cutaneous squamous cell carcinoma (SCCA) recurrence at the right upper-extremity donor site following tonsillar SCCA resection with supraclavicular artery island flap reconstruction. Following surgery, the patient presented with cutaneous recurrence at the right upper-extremity donor site. Read More

P R Health Sci J 2020 Mar;39(1):34-38

Department of Ophthalmology, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Objective: To describe the characteristics upon presentation of a cohort of Hispanic patients living in Puerto Rico with ocular mucous membrane pemphigoid (MMP).

Methods: Retrospective chart review of subjects with ocular MMP at one academic institution and one private practice. Patients with clinical evidence of ocular MMP, along with a positive mucous membrane biopsy revealing linear antibody or C3 deposition in the basement membrane zone, or with a positive indirect immunofluorescence assay were included. Read More

J Cancer Res Clin Oncol 2020 Jul 5;146(7):1677-1692. Epub 2020 May 5.

Department of Tumour Pathology, Maria Sklodowska-Curie Institute - Oncology Center, Cracow Branch, Cracow, Poland.

Purpose: HPV is involved in the development of some head and neck squamous-cell carcinomas (HNSCC). It was suggested that only transcriptionally active virus can induce carcinogenesis, therefore, the aim of our study was to analyze the frequency of active HPV infection, virus type, and its prognostic role in HNSCC patients.

Methods: Status of active HPV infection was assessed for 155 HNSCC patients based on p16 expression and HPV DNA presence. Read More

Malays J Pathol 2020 Apr;42(1)

Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Pathology, Kuala Lumpur, Malaysia.

No abstract available. Read More

Laryngoscope Investig Otolaryngol 2020 Apr 11;5(2):210-216. Epub 2020 Feb 11.

Department of Radiation Oncology Washington University School of Medicine in St. Louis St. Louis Missouri.

Objectives: We investigated how tonsillectomy during childhood may influence the distribution of human papillomavirus (HPV) positive cancer of the tonsils in adult life using p16 as a surrogate marker for HPV infection.

Study Design: Retrospective observational study.

Methods: A total of 280 patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC) and known p16 status were eligible for this study. Read More

Oral Oncol 2020 Apr 23;106:104719. Epub 2020 Apr 23.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria. Electronic address:

Objective: The incidence of oropharyngeal squamous cell carcinoma (OPSCC), especially human papillomavirus (HPV)-associated, is increasing worldwide. Immunotherapy become available for patients with carcinomas in the head and neck region, however without ideal biomarker. Markers like PD-L1 vary in the clone of the antibody used, and the method of evaluation. Read More

Viruses 2020 Apr 16;12(4). Epub 2020 Apr 16.

McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53705, USA.

Human head and neck cancers that develop from the squamous cells of the oropharynx (Oropharyngeal Squamous Cell Carcinomas or OPSCC) are commonly associated with the papillomavirus infection. A papillomavirus infection-based mouse model of oropharyngeal tumorigenesis would be valuable for studying the development and treatment of these tumors. We have developed an efficient system using the mouse papillomavirus (MmuPV1) to generate dysplastic oropharyngeal lesions, including tumors, in the soft palate and the base of the tongue of two immune-deficient strains of mice. Read More

Cureus 2020 Mar 17;12(3):e7297. Epub 2020 Mar 17.

Radiation Oncology, University of Louisville, Louisville, USA.

Simultaneous primary cancers are rare in the oropharynx. This report describes the first reported case of a collision tumor of squamous cell and adenoid cystic carcinoma in the soft palate. The patient was immunosuppressed with a history of liver transplantation, smoking and heavy alcohol drinking. Read More

Contemp Clin Dent 2019 Jul-Sep;10(3):531-541

Oral Health Division, Multidisciplinary Organizations for Technical and Health Education and Research, Kolkata, West Bengal, India.

Context: Oral submucous fibrosis (OSMF) is a high-risk premalignant condition of the oral cavity and oropharynx. Complete regression of the disease is still not possible with available treatment modalities.

Aims: The aim of the study was to evaluate the efficacy of curcumin, lycopene, and piperine as a combination in the management of OSMF. Read More

Int J Radiat Oncol Biol Phys 2020 Apr 13. Epub 2020 Apr 13.

Department of Human Oncology, University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin. Electronic address:

Purpose: We examined the capacity of the pan-fibroblast growth factor receptor (FGFR) inhibitor AZD4547 to augment radiation response across a panel of head and neck squamous cell carcinoma (HNSCC) cell lines and xenografts.

Methods And Materials: FGFR1, FGFR2, and FGFR3 RNA in situ hybridization expression was assessed in a cohort of HNSCC patient samples, cell lines, and patient-derived xenografts (PDXs). In vitro effects of AZD4547 and radiation on cell survival, FGFR signaling, apoptosis, autophagy, cell cycle, and DNA damage repair were evaluated. Read More

BMJ Case Rep 2020 Apr 14;13(4). Epub 2020 Apr 14.

Department of Medicine, NYU Langone Medical Center, New York, New York, USA.

In the era of highly active antiretroviral therapy (HAART), disseminated Kaposi sarcoma (KS) has become much rarer in the USA. We report a case of a 34-year-old man with KS of the skin, oropharynx, lung and rectum. Within the same lung nodule, we discovered significant burden of colesional in the context of a positive asymptomatic cryptococcal antigenemia, which was a previously unreported occurrence. Read More

Radiother Oncol 2020 Apr 1;148:14-20. Epub 2020 Apr 1.

Department of Radiation Oncology, BC Cancer Vancouver Centre, Canada. Electronic address:

Purpose: To evaluate the predictive value of FDG-PET/CT for detection of residual disease after radical radiotherapy for patients with squamous cell carcinoma (SCC) of the oropharynx, comparing p16 positive (+) versus p16 negative (-) disease.

Methods And Materials: A retrospective analysis of patients with SCC of the oropharynx at our institution treated with radical radiotherapy between 2012 and 2016 was performed. The primary and lymph node metabolic responses were evaluated independently on the post-treatment FDG-PET/CT. Read More

BMC Cancer 2020 Apr 15;20(1):316. Epub 2020 Apr 15.

Yonsei Cancer Center, Division of Medical Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.

Background: We investigated whether head and neck squamous cell carcinoma (HNSCC) patient-derived xenografts (PDXs) reaffirm patient responses to anti-cancer therapeutics.

Methods: Tumors from HNSCC patients were transplanted into immunodeficient mice and propagated via subsequent implantation. We evaluated established PDXs by histology, genomic profiling, and in vivo anti-cancer efficacy testing to confirm them as the authentic in vivo platform. Read More

Am J Case Rep 2020 Apr 13;21:e921967. Epub 2020 Apr 13.

Department of Radiology, Vinmec Healthcare System, Nha Trang City, Vietnam.

BACKGROUND The prevalence of aberrant internal carotid artery (ICA) is extremely low in the general population. It commonly occurs in the neck. Close proximity of the pulsatile submucosal mass of the aberrant ICA to the nasopharyngeal wall is dangerous. Read More

JGH Open 2020 Apr 6;4(2):312-314. Epub 2019 Sep 6.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University Niigata Japan.

A 61-year-old woman with hypereosinophilia and elevated interleukin (IL)-5 level was admitted to our hospital after detection of multiple liver tumors. Liver biopsy demonstrated that the tumor consisted of scar tissue with remnants of eosinophilic infiltration, suggesting that it had formed by massive eosinophilic infiltration. The hypereosinophilia was treated mainly by prednisolone, and thereafter, the liver tumors disappeared. Read More

Oral Oncol 2020 Jun 10;105:104670. Epub 2020 Apr 10.

Department of Pathology, Cork University Hospital, Wilton, Cork, Ireland; ENTO Research Unit, College of Medicine and Health, University College Cork, College Road, Cork, Ireland. Electronic address:

Objectives: There is no consensus on the optimal approach to human papilloma virus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC). Our objective was to classify OPSCC as HPV positive or negative based on (1) morphology alone, (2) p16 status alone, (3) combined morphology and p16 status with additional HPV testing in discordant cases in keeping with 2012 College of American Pathologists (CAP) guidelines (combined approach), and to evaluate and compare survival outcomes.

Materials And Methods: Retrospective review of 168 patients, 146 with OPSCC and 22 with cervical SCC of unknown primary site (SCCUP). Read More

Clin Cancer Res 2020 Apr 8. Epub 2020 Apr 8.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: In oropharyngeal squamous cell carcinoma (OPC), high CD8 tumor-infiltrating lymphocyte (CD8TIL) density confers improved prognosis. We compared neoadjuvant durvalumab (PD-L1 inhibitor) with durvalumab + tremelimumab (CTLA-4 inhibitor) in terms of impact on CD8TIL density, safety, and efficacy in patients with OPC.

Patients And Methods: Patients with newly diagnosed stage II-IVA OPC or locoregionally recurrent OPC amenable to resection were included. Read More

Braz Oral Res 2020 6;34:e032. Epub 2020 Apr 6.

Universidade Federal de Minas Gerais - UFMG, Hospital das Clínicas, Department of Surgery of the School of Medicine and Head and Neck Surgery, Belo Horizonte, MG, Brazil.

About 92,000 new cases of oropharynx carcinoma are expected to occur annually worldwide. There is no consensus about the best therapy for these advanced tumors. The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Read More

Rep Pract Oncol Radiother 2020 May-Jun;25(3):355-359. Epub 2020 Mar 19.

Department of Radiation Oncology, MS Ramaiah Medical College and Hospital, Bengaluru, India.

Aim: We conducted a study to validate the MDASI-HN based nomogram, which is used to predict the acute toxicities in head and neck cancer patients undergoing radiation therapy with or without chemotherapy.

Background: Tolerance to radiation varies from patient to patient and also depends on various other factors like tumor volume, dose of radiation, chemotherapy. Predicting the toxicities allow us to identify potential candidates who are likely to have a higher toxicity and, in addition, evaluates the nomogram when done on an independent group of patients. Read More

Zhonghua Zhong Liu Za Zhi 2020 Mar;42(3):247-251

Medical Affairs Office, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the causes and influencing factors of unplanned reoperation in head and neck neoplasms. A retrospective analysis was conducted on the clinical data of the operation treated patients with head and neck neoplasm in Cancer Hospital Chinese Academy of Medical Sciences from 2016 to 2018. Among 15 113 cases of head and neck neoplasms, 122 cases underwent unplanned reoperation, with an incidence of 0. Read More

Pathol Res Pract 2020 Mar 19:152924. Epub 2020 Mar 19.

Department of Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 675 N St Clair St, Galter 15-200, Chicago, IL 60611, United States.

We describe the case of a human papillomavirus-mediated adenocarcinoma of palatine tonsil in a 51-year-old male. Histologically, the tumor exhibited a predominantly cribriform and tubular (glandular) growth of cuboidal and columnar cells with moderate amount of pale eosinophilic cytoplasm and oval or spindled nuclei with finely dispersed or coarse chromatin and small to medium-sized nucleoli. Foci of nuclear anaplasia and multinucleation, numerous mitotic figures, and necrosis (individual-cell and confluent) were seen. Read More

JAMA 2019 Feb;321(5):493-503

Interdepartmental Division of Critical Care Medicine and Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Importance: Recognizing patients in whom endotracheal intubation is likely to be difficult can help alert physicians to the need for assistance from a clinician with airway training and having advanced airway management equipment available.

Objective: To identify risk factors and physical findings that predict difficult intubation.

Data Sources: The databases of MEDLINE and EMBASE were searched from 1946 to June 2018 and from 1947 to June 2018, respectively, and the reference lists from the retrieved articles and previous reviews were searched for additional studies. Read More

World Neurosurg 2020 Apr;136:444-453

Department of Neurological Surgery, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, USA. Electronic address:

Background: Cervicomedullary compression in young children has been described in the context of Chiari type 1 malformation, with symptoms associated with the extent of tonsillar herniation below McRae line. Historically, Chiari type 1 malformation has been defined by tonsillar herniation of at least 5 mm. However, in certain populations, including very young children, Chiari symptoms may be present without this finding. Read More

Am J Speech Lang Pathol 2020 May 23;29(2):864-872. Epub 2020 Mar 23.

Graduate Program of Human Communication Disorders, Dysphagia Laboratory, Federal University of Santa Maria, Rio Grande do Sul, Brazil.

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Read More

J Voice 2020 Mar 19. Epub 2020 Mar 19.

Graduate Program in Human Communication Health at the Federal University of Pernambuco, Health Sciences Center, Speech-Language Pathology and Audiology Department, Recife, Pernambuco, Brazil (Programa de Pós-Graduação em Saúde da Comunicação Humana da Universidade Federal de Pernambuco, Centro de Ciências da Saúde, Departamento de Fonoaudiologia), Av. Prof. Artur de Sá, s/n - Cidade Universitária, Recife/PE, Brazil. Electronic address:

Objective: To verify the immediate effect of the flexible resonance tube vocal technique on the oropharyngeal geometry and vocal acoustic parameters of individuals with Parkinson's disease (PD) and to study the correlation between oropharyngeal geometry and the intensity and fundamental frequency (f0) parameters of the voice.

Methods: Forty individuals participated-20 with PD and 20 healthy individuals, with a mean age of 60.95 (± 5. Read More

Am J Pathol 2020 04 19;190(4):862-873. Epub 2020 Mar 19.

Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas; Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas; Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York. Electronic address:

Group A streptococcus (GAS) is a major pathogen that impacts health and economic affairs worldwide. Although the oropharynx is the primary site of infection, GAS can colonize the female genital tract and cause severe diseases, such as puerperal sepsis, neonatal infections, and necrotizing myometritis. Our understanding of how GAS genes contribute to interaction with the primate female genital tract is limited by the lack of relevant animal models. Read More

J Craniofac Surg 2020 Mar 17. Epub 2020 Mar 17.

Department of Pathology, Inönü University, Turgut Özal Medicine Center, Malatya, Turkey.

Schwannoma is a benign slow growing nerve sheath tumor that is typically encapsulated and composed of well-differentiated schwann cells. Schwannomas may take origin from different nerves such as cranial, spinal nerves, and the sympathetic chain. Approximately 25% to 45% of all occur in the head and neck only 1% of them are located in the oral cavity. Read More

Med Oral Patol Oral Cir Bucal 2020 May 1;25(3):e431-e438. Epub 2020 May 1.

Faculdade de Odontologia de Piracicaba - UNICAMP Departamento de Diagnóstico Oral - Semiologia Av. Limeira, 901 CEP 13.414-903 Piracicaba, São Paulo, Brasil

Background: Although new digital pathology tools have improved the positive cell quantification, there is a heterogeneity of the quantification methods in the literature. The aim of this study was to evaluate and propose a novel dendritic cells quantification method in squamous cell carcinoma comparing it with a conventional quantification method.

Material And Methods: Twenty-six squamous cell carcinomas HIV-positive cases affecting the oropharynx, lips and oral cavity were selected. Read More

Anticancer Res 2020 Mar;40(3):1631-1636

Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C

Lymphangioma insults in adults are uncommon and the occurrence in the oropharynx is extremely rare. Although disease history and clinical symptoms may help in distinguishing it from malignant tumors, the pathophysiology of lymphangioma via histological examinations should be established for convenient and precise diagnosis. We present a 20-year-old male with lymphangioma in the right oropharynx, and the multiple-angle examination and treatment plan used. Read More

Cancer Cytopathol 2020 Mar 4. Epub 2020 Mar 4.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: High-risk human papillomavirus-positive (hrHPV+) oropharyngeal squamous cell carcinomas comprise a subset of head and neck squamous cell carcinomas (HNSCCs) with a distinct biology and prognosis. Commonly, the diagnosis of HNSCC is rendered on fine-needle aspiration (FNA). Because cell blocks may be insufficient for determining HPV status using microscopy-based techniques, the ability of liquid-based assays was examined in the current study. Read More

Forensic Sci Med Pathol 2020 Mar 3. Epub 2020 Mar 3.

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Adelaide, SA, 5005, Australia.

The carcass of a 15-year-old female Bottlenose dolphin (Tursiops aduncus) was retrieved from the Port River near Adelaide, South Australia, Australia. The animal was emaciated with five thick nylon fishing lines emerging from the oropharynx attached to a tangle of nylon and monofilament fishing line that also contained wire and eight fishing hooks. The mouth had been cut by the line and a circumferential curvilinear superficial abrasion/indentation from fishing line encircled the entire distal rostrum. Read More

J Am Soc Cytopathol 2020 May - Jun;9(3):177-184. Epub 2020 Feb 11.

Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.

Introduction: Human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) has been recognized to have an excellent response to treatment and has a distinct pathologic staging. For this reason, HPV testing is recommended in cytology specimens of metastatic OPSCC, although the guidelines for testing are not clearly defined. The aim of the current study was to establish a threshold for interpretation of p16 in aspirates from metastatic OPSCC. Read More

J Clin Microbiol 2020 04 23;58(5). Epub 2020 Apr 23.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

HNO 2020 Mar;68(3):215-226

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.

Adenoidectomy, paracentesis, and tonsillar interventions are the most common operations in childhood. Hypertrophy of the lymphatic tissue of Waldeyer's ring can lead to individually distinct, acute, and chronic symptoms as well as anatomical and functional changes. When presented with affected children in otolaryngologic practice, the combination of parental interview, questionnaire-based screening for obstructive sleep apnea syndrome, and physical examination including ear microscopy, inspection of the oropharynx and, if necessary, the nasopharynx, has proven its worth. Read More

World J Oncol 2020 Feb 2;11(1):1-8. Epub 2020 Feb 2.

Otolaryngology, Georgetown University School of Medicine, Veterans Affairs Medical Center, Washington, DC, USA.

Background: The rise in human papillomavirus (HPV) infection rates over the last few decades in the USA has contributed to a significant increase in the overall incidence of patients diagnosed with squamous cell carcinoma of the head and neck. These head and neck carcinomas develop in the oropharynx, with more than 90% of them caused by infection with high-risk HPV type 16. Patients diagnosed with HPV-induced oropharyngeal squamous cell carcinomas (OPSCCs) have a better prognosis and treatment response than those diagnosed with head and neck cancers caused by alcohol consumption and tobacco use. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):183-185

Sarcomatoid carcinoma, a malignant tumor containing both epithelial-derived malignant cells and malignant mesenchymal cells. Microscopically, cancer cells and sarcoma cells migrate to each other, and CK and Vimentin are simultaneously expressed. A rare case of tonsillar sarcomatoid carcinoma is discussed in our department with dysphagia as the first symptom. Read More

Iran J Otorhinolaryngol 2020 Jan;32(108):53-56

Department of Otorhinolaryngology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India, Pin-751019.

Introduction: Giant cavernous hemangioma involving the nose extending to the nasopharynx and oropharynx with complete obstruction of the airway is very unusual and is yet to be described in the literature. In the present case, we have described a giant cavernous hemangioma successfully managed with endoscopic excision.

Case Report: A 38-year-old male patient presented with recurrent nasal bleeding for 24 months and progressive obstruction of the right nasal cavity for 8 months. Read More

Molecules 2020 Feb 16;25(4). Epub 2020 Feb 16.

Rudjer Boskovic Institute, Laboratory for Oxidative Stress, Bijenička cesta 54, 10000 Zagreb, Croatia.

Tumor growth is associated with oxidative stress, which causes lipid peroxidation. The most intensively studied product of lipid peroxidation is 4-hydroxy-2-nonenal (HNE), which is considered as a "second messenger of free radicals" that binds to proteins and acts as a growth-regulating signaling factor. The incidence of squamous cell carcinoma of the oropharynx is associated with smoking, alcohol and infection of human papilloma virus (HPV), with increasing incidence world-wide. Read More

J Forensic Sci 2020 Feb 18. Epub 2020 Feb 18.

Department of Forensic Medicine, Seth Gordhandas Sunderdas Medical College & King Edward Memorial Hospital, Parel, Mumbai, Maharashtra, India.

Barium contrast radiography is a usual procedure performed for detecting lesions of the digestive tract using barium sulfate on X-ray irradiation. The aspiration of barium contrast is an uncommon but well-documented complication occurring accidentally during examinations of the upper gastrointestinal system using contrast media. Certain conditions that affect the anatomical and functional integrity of the oropharynx and esophagus can be predisposing factors. Read More

BMC Cancer 2020 Feb 14;20(1):125. Epub 2020 Feb 14.

Department of Radiation Oncology, London Health Sciences Centre, Western University, 800 Commissioners Rd. E, London, Ontario, N6A 5W9, Canada.

Background: Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients with HPV-negative disease. Treatment options for HPV+ OPC can involve either a primary radiotherapy (RT) approach (± concomitant chemotherapy) or a primary surgical approach (± adjuvant radiation) with transoral surgery (TOS). These two treatment paradigms have different spectrums of toxicity. Read More

PLoS One 2020 14;15(2):e0228327. Epub 2020 Feb 14.

Department of Microbiology, Immunology, and Pathology, Prion Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United states of America.

Chronic wasting disease (CWD) continues to spread or be recognized in the United States, Canada, and Europe. CWD is diagnosed by demonstration of the causative misfolded prion protein (PrPCWD) in either brain or lymphoid tissue using immunodetection methods, with immunohistochemistry (IHC) recognized as the gold standard. In recent years, in vitro amplification assays have been developed that can detect CWD prion seeding activity in tissues, excreta, and body fluids of affected cervids. Read More

Braz Oral Res 2020 7;34:e009. Epub 2020 Feb 7.

Universidade Federal de Santa Maria (UFSM), School of Dentistry, Department of Pathology, Santa Maria, RS, Brazil.

The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharynx, hypopharynx, or larynx cancer. A cross-sectional study was conducted with 90 cancer patients in follow up at the Santa Maria University Hospital in southern Brazil who had completed conformal 3D radiotherapy at least three months earlier. Read More

Oral Oncol 2020 Apr 7;103:104585. Epub 2020 Feb 7.

Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States.

Objectives: This study examines the utility of surveillance imaging in detecting locoregional failures (LRF), distant failures (DF) and second primary tumors (SPT) in patients with human papillomavirus (HPV) associated oropharyngeal cancer (OPC) after definitive chemoradiotherapy (CRT).

Methods And Materials: An institutional database identified 225 patients with biopsy proven, non- metastatic HPV+ OPC treated with definitive CRT between 2004 and 2015, whose initial post-treatment imaging was negative for disease recurrence (DR). Two groups were defined: patients with <2 scans/year Group 1 and patients with ≥2 scans/year Group 2. Read More

Pathobiology 2020 7;87(2):75-86. Epub 2020 Feb 7.

Radiation and Clinical Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland.

Introduction: Human papillomavirus with a high oncogenic potential (HR-HPV) is responsible for more than a half of squamous cell carcinomas of the oropharynx. The HR-HPV-dependent cases of this tumour have a better prognosis compared to the HR-HPV-negative cases, despite the usually more advanced disease at the time of diagnosis. In addition to genetic and epigenetic factors, the causes of this more favourable course of the disease are also seen in the participation of the tumour microenvironment, including the patient's immune system. Read More

Vestn Otorinolaringol 2019 ;84(6):11-16

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia, 117997.

The article presents modern ideas about the etiology, pathogenesis, and features of the clinical picture of chronic tonsillar pathology. Specific attention is paid to the classification of chronic tonsillitis, in particular the classification of B.S. Read More

TH Open 2020 Jan 23;4(1):e33-e35. Epub 2020 Jan 23.

Department of Pathology, Baylor College of Medicine, Houston, Texas, United States.

Angiotensin-converting enzyme (ACE) inhibitors are extensively prescribed to treat patients with hypertension, congestive heart failure, and diabetic nephropathy. A small fraction of these patients (approximately 0.7%) develop angioedema, manifested by swelling of the lips and oropharynx. Read More

J Mol Diagn 2020 Mar 22;22(3):419-428. Epub 2020 Jan 22.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Rapid and accurate identification of human papillomavirus (HPV) is important for both clinical management and population screening. Analytic validation of Atila AmpFire Multiplex HPV assays on formalin-fixed, paraffin-embedded (FFPE) cervix/vulva and oropharynx diagnostic tissue samples was performed. The AmpFire assay incorporates a novel isothermal multiplex amplification coupled with real-time fluorescent detection to detect and genotype 15 high-risk (HR) HPV genotypes. Read More