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Saudi J Med Med Sci 2018 Jan-Apr;6(1):32-35. Epub 2017 Dec 14.

Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

Pleomorphic adenoma is the most frequently encountered benign mixed tumor of the minor salivary gland and usually presents in the parotid; however, in the minor salivary gland, it is more common in the palate. Tumors of the minor salivary glands are uncommon, with the most common intraoral site reported being the hard and soft palate owing to the preponderance of minor salivary glands in this region followed by the lips. Pleomorphic adenoma arising from minor salivary glands of the lips tends to occur at an earlier age than it does at other sites. Read More

Virchows Arch 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil.

This study aimed to analyze the immunoexpression of cancer stem cell markers, CD44v6, and podoplanin in 91 patients with lip squamous cell carcinomas (LSCC). The immunostaining of podoplanin and CD44v6 was evaluated in ten high-power fields (× 400 magnification) at the invasive front of LSCC, using a semi-quantitative score method. Chi-square test or Fisher's exact test was used to verify the association of podoplanin and CD44v6 expressions with clinicopathologic variables. Read More

Afr Health Sci 2018 Dec;18(4):1098-1108

Department of Speech-Language Pathology and Audiology, Faculty of Humanities, University of Pretoria Private Bag X20, Hatfield 0028.

Background: There is limited description of the feeding characteristics of infants with unrepaired cleft lip and palate, exposed to HIV, but not necessarily infected.

Objective: To compare the feeding characteristics of infants with unrepaired cleft lip and palate and HIV-exposure, to infants with unrepaired cleft lip and palate only.

Method: A two-group comparative design with a validated measure, the Neonatal Feeding Assessment Scale was used. Read More

J Forensic Dent Sci 2018 May-Aug;10(2):88-91

Dental Consultant, Vellore, Tamil Nadu, India.

Background: The "gender determination" which is an important human identification procedure not only helps in establishing the biological profile from skeletal and dental remains but also in facial reconstruction of unidentified victims.

Aim: The aim of this study is to analyze predominant types of lip prints (cheiloscopy), accuracy of mandibular canine index (MCI) (odontometric), and facial index in the study population and to identify whether any correlation among the above parameters could help forensic dentistry in solving crimes.

Materials And Methods: A pilot study was conducted in 100 individuals, 50 males and 50 females aged between 20 and 25 years. Read More

Open Access Maced J Med Sci 2019 Jan 3;7(1):19-23. Epub 2019 Jan 3.

Institute of Pathology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Squamous cell carcinoma (SCC) of the lower lip is a relatively rare carcinoma, with the incidence of 1 to 2%, but it is the most common carcinoma in the oral cavity accounting for 25-30% of all malignant oral tumours.

Aim: This study aimed to determine the role of neovascularisation in the process of tumour progression.

Methods: We analysed the surgical specimens obtained from 60 patients with squamous cell carcinoma (SCC) of the lower lip. Read More

J Nepal Health Res Counc 2019 Jan 28;16(41):462-466. Epub 2019 Jan 28.

Department of Oral Pathology, KIST Medical College and Hospital, Imadole Kathmandu, Nepal.

Background: The nose is a pyramidal shaped structure situated in the midline of midface being attached to the facial skeleton. The shape, size and spatial location of the nose-philtrum-upper lip complex are important from aesthetic point of view. Hence, to study the nasal parameters, shape of nostril and philtrum among the undergraduate students remained as the main aim of this study. Read More

J Helminthol 2019 Feb 8:1-9. Epub 2019 Feb 8.

Department of Plant Pathology,Faculty of Agriculture,Tarbiat Modares University,Tehran,Iran.

This contribution provides morphological and molecular data for one new and one known species of the genus Pungentus. The first species, P. azarbaijanensis n. Read More

J Prosthet Dent 2019 Feb 26;121(2):225-228. Epub 2018 Oct 26.

Associate Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Tuberculosis (TB) of the oral cavity may be overlooked in the differential diagnosis of oral lesions and can be misdiagnosed and managed incorrectly. A 66-year-old man with complete dentures presented with a nonhealing mucosal ulcer in the upper lip. Despite the treatments performed by a local medical clinic, the ulcerative lesion on the denture-bearing area had not improved over 5 months. Read More

BMC Med Genomics 2019 Jan 31;12(Suppl 1):16. Epub 2019 Jan 31.

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St., Suite 820, Houston, TX, 77030, USA.

Background: Cleft lip (CL) is one of the most common congenital birth defects with complex etiology. While genome-wide association studies (GWAS) have made significant advances in our understanding of mutations and their related genes with potential involvement in the etiology of CL, it remains unknown how these genes are functionally regulated and interact with each other in lip development. Currently, identifying the disease-causing genes in human CL is urgently needed. Read More

J Clin Exp Dent 2019 Jan 1;11(1):e62-e69. Epub 2019 Jan 1.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Background: To investigate the prevalence of malignant and potentially malignant lesions of the lip in an oral pathology service and to compare these data with a literature review.

Material And Methods: A total of 3173 biopsy reports and histopathological records were analyzed. Cases with a histological diagnosis of actinic cheilitis (AC) with or without epithelial dysplasia, in situ carcinoma, or lip squamous cell carcinoma (LSCC) were included. Read More

Cleft Palate Craniofac J 2019 Jan 29:1055665618823936. Epub 2019 Jan 29.

7 Plastic and Maxillofacial Surgery, Royal Children's Hospital, Parkville, VIC, Australia.

Objective:: Subclinical phenotypes of nonsyndromic cleft lip with or without cleft palate (CL ± P) may be identified from clinically "unaffected" relatives and could be associated with specific cleft-related gene mutations. It has been hypothesized that velopharyngeal insufficiency (VPI) may be a subclinical phenotype of interest in this population, but this has not been explored quantitatively with appropriate control cohorts. The aim of this case-control study was to compare VPI in at-risk clinically unaffected relatives of individuals with nonsyndromic CL ± P with a low-risk matched normative Australian cohort. Read More

Neurol India 2019 Jan-Feb;67(Supplement):S94-S99

Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Introduction: Sjogren's syndrome (SS) is a systemic autoimmune disease that apart from involving the exocrine glands can affect any organ. Involvement of the peripheral nervous system results in a wide spectrum of neuropathic manifestations.

Objective: To evaluate the clinico-electrophysiological patterns as well as pathological characteristics of neuropathy in SS patients presenting to a neuromuscular clinic in a tertiary hospital from South India. Read More

Clin Oral Investig 2019 Jan 23. Epub 2019 Jan 23.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Objectives: The objective of the study is to assess, by clinical follow-up, the efficacy of the dermatological cream Fludroxycortide 0.125 mg/g (Drenison®) in the treatment of actinic cheilitis (AC).

Material And Methods: Twenty-three patients diagnosed with AC participated in the study. Read More

J Hum Genet 2019 Jan 22. Epub 2019 Jan 22.

College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar.

A decade ago, we described novel de novo submicroscopic deletions of chromosome 14q11.2 in three children with developmental delay, cognitive impairment, and similar dysmorphic features, including widely-spaced eyes, short nose with flat nasal bridge, long philtrum, prominent Cupid's bow of the upper lip, full lower lip, and auricular anomalies. We suggested that this constituted a new multiple congenital anomaly-intellectual disability syndrome due to defects in CHD8 and/or SUPT16H. Read More

Cleft Palate Craniofac J 2019 Jan 22:1055665618825403. Epub 2019 Jan 22.

2 Department of Psychology, Montclair State University, Montclair, NJ, USA.

Objective:: Research has argued that a speaker's facial appearance can result in an "intelligibility cost" for the listener. The study investigated whether such an intelligibility cost exists for a visible repaired cleft lip and nasal asymmetry.

Setting:: University department. Read More

Comb Chem High Throughput Screen 2019 Jan 21. Epub 2019 Jan 21.

Department of Respiration, Jinhua Central Hospital, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang, 321000. China.

Objective: Explored the application and diagnostic value of high-resolution CT in the process of lymphocytic interstitial pneumonia clinical diagnosis, and analyzed one case of CT-guided percutaneous lung biopsy lymphocytic interstitial pneumonia.

Methods: The medical record of a patient with lymphocyte interstitial pneumonia (LIP) who came to the clinic on 2014-04-22 were analyzed and summarized retrospectively.

Results: The patient is a 55 years old female farmer. Read More

Nat Commun 2019 01 21;10(1):353. Epub 2019 Jan 21.

Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from 46 primary human muscosal, 65 primary canine oral and 28 primary equine melanoma cases from mucosal sites. Analysis of these data reveals recurrently mutated driver genes shared between species such as NRAS, FAT4, PTPRJ, TP53 and PTEN, and pathogenic germline alleles of BRCA1, BRCA2 and TP53. Read More

Front Immunol 2018 4;9:3015. Epub 2019 Jan 4.

Laboratory of Cell-Cell Interactions, Instituto de Ciências Biológicas, Departamento de Morfologia, Belo Horizonte, Brazil.

B-cells mediate humoral adaptive immune response via the production of antibodies and cytokines, and by inducing T-cell activation. These functions can be attributed to distinct B-cell subpopulations. Infection with , the causative agent of Chagas disease, induces a polyclonal B-cell activation and lytic antibody production, critical for controlling parasitemia. Read More

J Med Genet 2019 Jan 19. Epub 2019 Jan 19.

Epithelial Interactions in Cancer Department, Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal.

encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is involved in major cellular processes such as embryogenesis and maintenance of tissue architecture, it is no surprise that deleterious effects arise from its loss of function. E-cadherin is recognised as a tumour suppressor gene, and it is well established that genetic alterations cause diffuse gastric cancer and lobular breast cancer-the foremost manifestations of the hereditary diffuse gastric cancer syndrome. Read More

J Orofac Sci 2018 Jul-Dec;10(2):86-95. Epub 2019 Jan 2.

Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Affiliated to the Tamil Nadu Dr. M.G.R. Medical University.

Objective: Schizophrenia is a psychiatric disorder that requires long-term treatment. Long-term antipsychotic treatment is often associated with the emergence of tardive dyskinesia (TD), the severity of which is measured by Abnormal Involuntary Movement Scale (AIMS). This study examined the relationship among TD, orofacial musculature activity, and patient's awareness of AIM. Read More

J Cutan Med Surg 2019 Jan 17:1203475418825112. Epub 2019 Jan 17.

3 Department of Pathology, Dental School, University of São Paulo, Brazil.

Background:: The terms exfoliative cheilitis, factitial cheilitis, and morsicatio labiorum are used to describe self-inflicted lesions of the lip.

Objective:: Here we report and analyze clinical, pathological, and therapeutic data on 13 patients with a form of factitial cheilitis that we believe should be considered a separate entity.

Results:: Eight patients were male and 5 patients were female. Read More

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):451

Department of Oral Pathology and Microbiology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India.

Background: Twins are similar in many ways owing to the genetical and environmental factors. However, still, there are certain things that are not similar among them, and this is the challenge for personal identification among the twins.

Objectives: Our present study aimed to know and assess the similarities and differences present between the monozygotic (identical) and dizygotic (fraternal) twins in relation to lip prints, palm prints, fingerprints and blood group and to evaluate their heritability among parents and their offspring. Read More

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):401-405

Department of Conservative Dentistry and Endodontics, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.

Chondroid syringoma (CS) (mixed tumor of the skin) is a rare neoplasm of the sweat glands, which presents itself as a slow-growing, painless, nonulcerated, subcutaneous or intracutaneous mass often occurring in the head and neck region. The clinician may miss the diagnosis of this lesion due to its rarity. CS should be considered in the differential diagnosis of any subcutaneous nodules, especially in the head and neck region. Read More

Zootaxa 2018 Dec 3;4526(4):576-588. Epub 2018 Dec 3.

Lab of Plant Nematology/Research Center of Nematodes of Plant Quarantine, Department of Plant Pathology/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Agriculture, South China Agricultural University, Guangzhou, Guangdong, China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, Guangdong 510160, China.

A new species, Eudorylaimus piceae n. sp., extracted from rhizosphere soil of Picea crassifolia from Inner Mongolia, China was identified. Read More

Genet Test Mol Biomarkers 2019 Jan;23(1):45-50

16 WHO Collaborating Centre, University of Dundee Dental School, Dundee, Scotland.

Objective: Nonsyndromic orofacial cleft (NSOFC) including cleft lip with or without cleft palate (CL±P) and cleft palate (CP) are multifactorial developmental disorders with both genetic and environmental etiological factors. In this study we investigated the association between CL±P and CP, and two polymorphisms previously determined using genome-wide association studies, as well as the association between consanguinity and CL±P and CP.

Methods: DNA was extracted from saliva specimens from 171 triads consisting of affected individuals and their parents, as well as 189 control triads (matched for age, gender, and location) that were recruited from 11 referral hospitals in Saudi Arabia. Read More

Curr Health Sci J 2018 Jan-Mar;44(1):39-47. Epub 2018 Mar 21.

Oral Health Department, University of Medicine and Pharmacy of Craiova, Romania.

Purpose: The objective of this study was to review lip tumor diagnosed subjects from Oltenia region, in the past 5 years according to gender, age, home environment, profession, geographic area, smoking habit, associated diseases, tumor location, macroscopic aspect and histological type.

Material And Methods: The study was done at the Oral and Maxillo-Facial Clinic of the Emergency Clinical County Hospital of Craiova, and involved the analysis of patient file records, surgical registers, histopathological bulletins, from 2012-2016.

Results: Of the 175 subjects included in this study, all of them diagnosed with lip tumor pathology, 109 (62. Read More

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

Hematol Oncol Stem Cell Ther 2018 Dec 31. Epub 2018 Dec 31.

Department of Radiation Oncology, University of Turin School of Medicine, Mauriziano Umberto I Hospital, Turin, Italy. Electronic address:

Non-Hodgkin lymphoma (NHL) of the lip is extremely rare. It is usually indolent and in early stages a local approach is often indicated. We present a case report of a patient with extranodal NHL of the lip treated with chemotherapy and low-dose radiation treatment (RT). Read More

Lung India 2019 Jan-Feb;36(1):38-47

Department of Pathology, University of Pennsylvania, Philadelphia, PA, USA.

We reviewed the various physical signs of chronic obstructive pulmonary disease, their pathogenesis, and clinical importance. We searched PubMed, EMBASE, and the CINAHL from inception to March 2018. We used the following search terms: chronic obstructive pulmonary disease, physical examination, purse-lip breathing, breath sound intensity, forced expiratory time, abdominal paradox, Hoover's sign, barrel-shaped chest, accessory muscle use, etc. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Nov 16. Epub 2018 Nov 16.

Professor, Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address:

Objective: The aim of this study was to evaluate the expression of Twist and E-cadherin in lower lip squamous cell carcinoma (LLSCC) and their association with clinicopathologic parameters.

Study Design: Fifty-nine cases of LLSCC were analyzed by applying immunohistochemistry techniques in a semiquantitative manner. The systems proposed by Bryne et al. Read More

Tomography 2018 Dec;4(4):172-181

Departments of Clinical Sciences/Division of Radiology.

We investigated multivoxel proton magnetic resonance spectroscopy (H-MRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-grade glioma (LGG) and high-grade glioma (HGG). In total, 33 patients (HGG, 14; LGG, 9; and 10 MET) were included. H-MRS imaging (MRSI) data were assessed and neurochemical profiles for metabolites N-acetyl aspartate (NAA) + NAAG(NAA), Cr + PCr(total creatine, tCr), Glu + Gln(Glx), lactate (Lac), myo-inositol(Ins), GPC + PCho(total choline, tCho), and total lipids, and macromolecule (tMM) signals were estimated. Read More

Am J Hum Genet 2019 Jan 20;104(1):164-178. Epub 2018 Dec 20.

Department of Pediatrics, CHU Sainte-Justine Research Center and University of Montreal, Montreal, QC H3T 1C5, Canada. Electronic address:

SMARCC2 (BAF170) is one of the invariable core subunits of the ATP-dependent chromatin remodeling BAF (BRG1-associated factor) complex and plays a crucial role in embryogenesis and corticogenesis. Pathogenic variants in genes encoding other components of the BAF complex have been associated with intellectual disability syndromes. Despite its significant biological role, variants in SMARCC2 have not been directly associated with human disease previously. Read More

Int J Pediatr Otorhinolaryngol 2019 Feb 20;117:131-137. Epub 2018 Nov 20.

Department of Otolaryngology & Communication Enhancement, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, United States; Department of Otolaryngology, Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, United States. Electronic address:

Objective: To discuss the presentation, evaluation, and management of squamous cell carcinoma of the head and neck in the pediatric population.

Methods: Medical records of pediatric (≤20 years) patients treated for squamous cell carcinoma of the head and neck between 1996 and 2016 were reviewed. Data pertaining to clinical presentation, diagnostic methods, treatment plan, complications, recurrence, follow-up, or outcome were collected. Read More

Int J Pediatr Otorhinolaryngol 2019 Mar 7;118:1-5. Epub 2018 Dec 7.

Department of Psychiatry, Hospital Canselor Tuanku Mukhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Objective: There is a dearth of studies on long term hearing status and behavioural patterns among cleft lip and/or palate children after their primary lip and palate closure in Malaysia. This study describes the audiology status and behavioural patterns in a group of school aged children with cleft lip and/or palate.

Method: A cross sectional study was carried out where caretakers of cleft lip and/or palate were asked to complete the translated Malay language version of Strength Difficulties Questionnaire. Read More

Int J Surg Case Rep 2018 22;53:471-474. Epub 2018 Nov 22.

Department of Oncology, Hanoi Medical University, No 1 Ton That Tung Street, Dong Da District, Hanoi, Viet Nam; Department of Oncology and Palliative Care, Hanoi Medical University Hospital, No 1 Ton That Tung Street, Dong Da District, Hanoi, Viet Nam; Department of Head and Neck Surgery, Vietnam National Cancer Hospital, No 30 Cau Buou Street, Thanh Tri District, Hanoi, Viet Nam. Electronic address:

Introduction: Squamous cell carcinoma (SCC) of lower lip comprises over 25% of oral cancer. Surgical treatment plan for SCC patients includes tumor excision, lymph node dissection and reconstruction.

Case Presentation: A 68-year-old patient was admitted with 1-year history of tumor in his lower lip. Read More

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e21-e22

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A.

This is the first reported case of necrotizing nasal and sinus herpes infection with orbital involvement. A 94-year-old male with a past medical history of hypertension, congestive heart failure, and chronic kidney disease presented with necrotic nasal cellulitis and a red left eye with blurry vision. Onset was 2 weeks prior with an upper lip fever blister. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13664

Department of Nephrology, Yueyang hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, China.

Introduction: Renal glucosuria is a renal tubular disorder caused by genetic conditions, drugs, and poisons. Mutations in the SLC5A2 gene are recently found to be responsible for the inherited renal glucosuria, while undifferentiated connective tissue disease (UCTD) was not considered pathogenic for renal glucosuria. Here, we present a case of acquired renal glucosuria in a UCTD patient. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13630

Department of Oral Medicine.

Rationale: Biopsy is very important for the diagnosis of oral lichen planus (OLP) on the lips. Traditional Chinese medicine (TCM) can be used to coordinate the whole body, soften and eliminate swellings and masses, and regulate the functions of qi and blood. Therefore, TCM could be an effective and safe treatment for OLP. Read More

Oral Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathology, Ankara A.Y. Oncology Education and Research Hospital, Ankara, Turkey.

Objectives: This study was aimed to overview the treatment protocols of lip cancer and find out a cutoff point of tumor diameter and depth of invasion (DOI) for the survival parameters.

Materials And Methods: One hundred and ninety-one patients with lip SCC were studied.

Results: The average age of the patients was 62 years. Read More

Rom J Morphol Embryol 2018 ;59(3):949-953

"Victor Babeş" National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania;

Ionizing radiation was used in the past for treatment of several benign cutaneous conditions, and particularly hemangiomas. Even though radiotherapy was generally effective, it significantly augmented the risk for malignancies, resulting in a consequent heavy decline of its use for benign conditions. However, radiation-induced neoplasia is still encountered in adult patients irradiated during childhood or adolescence. Read More

Rom J Morphol Embryol 2018 ;59(3):839-849

Department of Dental Materials, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania;

Lip cancers account for 10-12% of the total head and neck cancers and, although squamous cell carcinoma is by far the most common lower lip cancer, the basal cell carcinoma (BCC) seems to be more common for the upper lip. Most BCCs have a clinically indolent behavior, but there are also local aggressive and∕or metastatic cases, with the incidence of such cases being estimated at about 1-10% of all cases of BCC. Many of the molecular mechanisms underlying this aggression are still unknown, which is why our study aimed to investigate the potential prognosis of a few markers, such as C-X-C chemokine receptor type 4 (CXCR4), alpha-smooth muscle actin (α-SMA) and Wiskott-Aldrich syndrome like (WASL) in upper lip BCCs. Read More

J Craniomaxillofac Surg 2019 Jan 16;47(1):106-111. Epub 2018 Nov 16.

Department of the Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Purpose: To describe the effectiveness and safety of a sclerotherapy protocol with 5% ethanolamine oleate (EO) at 0.1 mL/3 mm for oral vascular anomalies (OVAs). Our hypothesis is that EO applied at a concentration of 5% may decrease the number of sessions necessary for clinical healing. Read More

Cleft Palate Craniofac J 2018 Dec 9:1055665618817654. Epub 2018 Dec 9.

1 Division of Speech & Language Pathology, CLINTEC, Karolinska Institutet, Stockholm, Sweden.

Case Rep Pathol 2018 31;2018:1392975. Epub 2018 Oct 31.

Department of Pathology, Farwaniya Hospital, Kuwait.

Background: The transformation of nonosseous soft tissue into bone is known as osseous metaplasia (OM). This condition most commonly affects the musculoskeletal and central nervous systems and it is a well-known phenomenon in different soft tissue organs. Rarely, OM can affect the uterus, which can extend into the cervix. Read More

World Neurosurg 2018 Nov 26. Epub 2018 Nov 26.

Department of Neurosurgery, Juntendo University, Tokyo, Japan.

Objective: To describe microsurgical anatomy of the rhomboid lip (RL) and to consider its role by presenting histology and clinical cases.

Methods: We examined 10 (20 sides) formalin-fixed adult human cadaveric heads injected with colored silicone. A total of 20 RLs were examined posteriorly. Read More

J Stomatol Oral Maxillofac Surg 2018 Nov 26. Epub 2018 Nov 26.

Department of Oral and Maxillofacial surgery, Belgium.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Barts and The London School of Medicine and Dentistry, London, United Kingdom.

Importance: Cutaneous squamous cell carcinoma (cSCC) is the most common skin cancer with metastatic potential, but epidemiologic data are poor. Changes to the National Cancer Registration and Analysis Service (NCRAS) in England have allowed more accurate data analysis of primary and metastatic cSCC since 2013.

Objective: To assess the national incidence of cSCC and metastatic cSCC (mcSCC) in England from 2013 through 2015. Read More

Med Sci Monit 2018 Nov 28;24:8608-8620. Epub 2018 Nov 28.

Department of Orthodontics, Faculty of Dentistry, Akdeniz University, Antalya, Turkey.

BACKGROUND In cleft lip and palate (CLP) patients, the shape of the facial soft tissues shows variety in 3 dimensions (3D). Two-dimensional (2D) photographs and radiographs are insufficient in the examination of these anomalies. The aim of this retrospective study was to examine the soft tissue and craniofacial characteristics of individuals with nonsyndromic unilateral cleft lip and palate (UCLP), bilateral cleft lip and palate (BCLP), skeletal Class III malocclusions, or skeletal Class I malocclusions using 3D facial imaging. Read More

J Exp Clin Cancer Res 2018 Nov 27;37(1):286. Epub 2018 Nov 27.

Department of Oncology, University of Torino, via Santena 5/bis, 10126, Turin, Italy.

Background: Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER). Interfering with these mechanisms may overcome the resistance to doxorubicin, a still unmet need in TNBC.

Methods: We analyzed a panel of human and murine breast cancer cells for their resistance to doxorubicin, Pgp expression, lysosome and proteasome activity, nitrite production, ER-dependent cell death and immunogenic cell death parameters. Read More

J Clin Med 2018 Nov 24;7(12). Epub 2018 Nov 24.

School of Medicine for International Students, I-Shou University, Kaohsiung 82445, Taiwan.

Oral squamous cell carcinoma (OSCC) is one of the most common cancer types worldwide and can be divided into three major subsites: buccal mucosal SCC (BMSCC), tongue SCC (TSCC), and lip SCC (LSCC). The autophagy marker microtubule-associated protein light chain 3B (MAP1LC3B) and adaptor sequestosome 1(SQSTM1) are widely used proteins to evaluate autophagy in tumor tissues. However, the role of MAP1LC3B and SQSTM1 in OSCC is not fully understood, particularly in certain subsites. Read More