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Br J Oral Maxillofac Surg 2020 Jul 3. Epub 2020 Jul 3.

University Hospitals Leuven, Campus Sint-Rafaël, Department of Oral and Maxillofacial Surgery, Kapucijnenvoer 33, 3000 Leuven, Belgium; OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, Catholic University of Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium.

We have investigated the long-term incidence of neurosensory disturbances after modified bilateral sagittal split osteotomy, and identified associated risk factors. We prospectively studied 376 patients, and their self-reported neurosensory disturbances were evaluated six months, and one, two, and three years postoperatively. The correlations between the following risk factors and neurosensory disturbances were investigated using univariate analysis and stepwise multivariate analysis: age at operation, sex, type of movement (advancement, setback, or rotation), concurrent genioplasty, type of detachment, iliac crest bone graft, and use of dicalcium phosphate synthetic bone graft. Read More

J Helminthol 2020 Jun 19;94:e164. Epub 2020 Jun 19.

Departamento de Biología Animal, Biología Vegetal y Ecología, Universidad de Jaén, Campus 'Las Lagunillas' s/n, Edificio B3, 23071Jaén, Spain.

Two species of the genus Aporcella, one new and one previously known, collected from cultivated fields in Iran are studied. Description, morphometrics, illustrations (both line and microphotographs) and D2-D3 sequences are provided for Aporcella talebii sp. n. Read More

J Stomatol Oral Maxillofac Surg 2020 Jul 1. Epub 2020 Jul 1.

Division of Oral and Maxillofacial Surgery, Department of Reconstructive Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 19-1, Uchimaru, 020-8505 Morioka, Iwate, Japan.

Cryosurgery is a recognized method for the treatment of mucoceles in the oral cavity. In this study, cryosurgery was used for mucoceles at the lip or buccal mucosa, and the effect and the indication were evaluated clinically. The subjects were patients with a clinical diagnosis of mucocele on the lip or buccal mucosa and who chose cryosurgery after procedures for both surgical excision and cryosurgery for the lesion were explained. Read More

Clin Genet 2020 Jul 3. Epub 2020 Jul 3.

Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Neural tube defects (NTD) are among the most common congenital anomalies, affecting about 1:1000 births. In most cases, the etiology of NTD is multifactorial and the genetic variants associated with them remain largely unknown. There is extensive evidence from animal models over the past two decades implicating SHROOM3 in neural tube formation; however, its exact role in human disease has remained elusive. Read More

J Biol Regul Homeost Agents 2020 May-Jun;34(3 Suppl. 1):117-127

Cleft Lip and Palate Center, Plastic and Reconstructive Surgery Unit, Santa Chiara Hospital, Pisa, Italy.

Cleft lip and/or palate patients (CLP) undergo corrective surgery that can affect facial growth. The aim of this study was to analyze facial growth and maxillary development of CLP subjects after surgery according to P.I. Read More

Clin Cosmet Investig Dent 2020 23;12:219-224. Epub 2020 Jun 23.

Department of Restorative Dentistry, Howard University College of Dentistry, Washington, DC, USA.

A case of a 19-year-old female patient is presented to a private practice dental clinician with swelling of the lower lip and inflammation of the anterior dorsal tongue. The patient presented with moderate oral pain as well as abdominal pain. The lesions were biopsied and noted for a granulomatous histopathologic appearance. Read More

J Cutan Pathol 2020 Jun 23. Epub 2020 Jun 23.

Department of Pathology, Dental School- University of São Paulo, Brazil.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare disease characterized by the triad of recurrent orofacial edema, relapsing facial paralysis and plicated tongue. Histopathological features of MRS have not been extensively analyzed.

Methods: The present study investigated the histopathological aspects of oral lesions from 47 MRS patients. Read More

Actas Dermosifiliogr 2020 Jun 20. Epub 2020 Jun 20.

Instituto de Biomedicina "Dr. Jacinto Convit". Venezuela. Médico Pediatra. Dermatólogo. Adjunta de la Consulta de Atención a Pacientes con Enfermedad de Hansen, Venezuela.

Background And Objective: Hansen disease, or leprosy, is caused by Mycobacterium leprae or Mycobacterium lepromatosis. Because these bacteria enter the body via the upper airways, they generate clinical manifestations in the nasal mucous membranes and the mouth. We aimed to describe the characteristics of oral lesions in patients with Hansen disease. Read More

J Liposome Res 2020 Jun 22:1-9. Epub 2020 Jun 22.

Clinical Laboratory, Zhejiang Province Tongde Hospital, Hangzhou, Zhejiang, China.

A novel antioxidant glutathione liposomes (GSH-LIP) were prepared and applied for diabetic nephropathy therapy. GSH-LIP not only improve the bioavailability and antioxidant capacity of glutathione to scavenge redundant ROS inducing by oxidative stress, but also effectively inhibit the activity of AR and sorbitol accumulation in polyol pathway. The imaging in vivo showed that GSH-LIP could target kidney and significantly improve renal pathology. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2020 Jun;29(2):67-72

School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Currently, there are no clear recommendations for diagnostic management of lip inflammation and cheilitis, which is evident in the varied nomenclature and subtypes found in medical literature on cheilitis. This can confound diagnostic management. We therefore recently put forth a proposal for cheilitis classification, defining three groups of cheilitis based on duration and etiology: mainly reversible cheilitis, mainly irreversible cheilitis, and cheilitis connected to other diseases. Read More

Mol Genet Genomic Med 2020 Jun 17:e1355. Epub 2020 Jun 17.

Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, USA.

Background: The development of the face occurs during the early days of intrauterine life by the formation of facial processes from the first Pharyngeal arch. Derangement in these well-organized fusion events results in Orofacial clefts (OFC). Van der Woude syndrome (VWS) is one of the most common causes of syndromic cleft lip and/or palate accounting for 2% of all cases. Read More

Braz Dent J 2020 Mar-Apr;31(2):186-189

Department of Oral Pathology, São Leopoldo Mandic, Campinas, SP, Brazil.

This report describes the diagnostic process of a rare disorder in a Brazilian female child. The patient presented initially as a 7-year-old with multiple whitish submucosal nodules of a fibrous consistency in the lower lip, but with an inconclusive pathology report. When she turned 9 years of age, she presented with exacerbation of the original clinical findings, which then involved the upper lip, buccal mucosa, tongue and lingual frenulum. Read More

Development 2020 Jun 18. Epub 2020 Jun 18.

Departments of Pathology & Laboratory Medicine and Biology, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC, USA

Cleft palate (CP), one of the most common congenital diseases, arises from failures in secondary palatogenesis during embryonic development. Several human genetic syndromes featuring CP and ectodermal dysplasia have been linked to mutations in genes regulating cell-cell adhesion, yet mouse models have largely failed to recapitulate these findings. Here, we utilize lentiviral-mediated genetic approaches in mice to provide the first direct evidence that the nectin-afadin axis is essential for proper palate shelf elevation and fusion. Read More

Indian J Otolaryngol Head Neck Surg 2020 Jun 26;72(2):214-220. Epub 2019 Nov 26.

Department of ENT, ESI PGIMSR, Basaidarapur, Guru Gobind Singh Indraprastha University, New Delhi, India.

We report four cases of embryonal rhabdomyosarcoma treated successfully with multimodality therapy which included surgery, chemotherapy and radiotherapy. Our first case was a 2 year old who admitted with the chief complaint of swelling of the upper lip. Biopsy was taken, which showed embryonal rhabdomyosarcoma. Read More

Am J Otolaryngol 2020 May 26;41(5):102556. Epub 2020 May 26.

Department of Otorhinolaryngology Head and Neck Surgery, Konya Training and Research Hospital, University of Health Sciences Turkey, Konya, Turkey.

Turk Patoloji Derg 2020 Jun 11. Epub 2020 Jun 11.

Department of Pathology, Faculty of Medicine, Usak University, UŞAK, TURKEY.

Sirenomelia, which is also known as mermaid syndrome and characterized by the fusion of the lower extremities, is the most severe form of caudal regression syndrome and one of the rare and lethal congenital malformations. The anomalies that might be seen in this syndrome include pelvic-sacral dysplasia, genital anomalies, bilateral pelvic renal fusion accompanied by renal dysplasia, colon atresia, unilateral umbilical artery, and imperforated anus. The incidence of sirenomelia is 0. Read More

BMC Health Serv Res 2020 Jun 11;20(1):528. Epub 2020 Jun 11.

Department of Plastic Surgery, Skåne University Hospital, Malmö, Sweden.

Background: The objective of the Swedish cleft lip and palate (CLP) registry is to promote quality control, research and improvement of treatment, by comparison of the long-term results of surgery, orthodontics and speech from all six Swedish CLP centres. The purpose of the study was to investigate the coverage and reporting degree of the Swedish CLP registry, and to describe the design of the registry and discuss questions of reliability and validity of the data included.

Methods: All six Swedish CLP centres participate in the registry. Read More

Clin Rheumatol 2020 Jun 5. Epub 2020 Jun 5.

The Department of Internal Medicine, The Division of Rheumatology, Akdeniz University Medical School, Antalya, Turkey.

Objectives: This study compared the clinical and serological characteristics of seronegative and seropositive primary Sjögren syndrome (pSS) and examined whether current classification criteria for pSS cover seronegative pSS.

Methods: The study group comprised 375 patients (341 women and 34 men) diagnosed with pSS. A clinical diagnosis by an expert rheumatologist was considered the "gold standard" for the diagnosis of pSS. Read More

Clin Case Rep 2020 May 3;8(5):804-807. Epub 2020 Mar 3.

Mazandaran University of Medical Sciences Sari Iran.

Eosinophilic ulcer (EU) is a rare self-limiting chronic benign lesion of the oral mucosa. It is an uncommon and benign disease, which may leading to diagnostic difficulties. Biopsy is recommended to rule out any malignant etiology. Read More

Z Rheumatol 2020 May 30. Epub 2020 May 30.

Klinik für Rheumatologie und Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

A 64-year-old male patient developed over a period of 20 years a peripheral neuropathy symmetrically affecting the upper and lower limbs. The histological examination of a sural nerve biopsy revealed a severe axonal neuropathy. Despite extensive laboratory investigations including immunological and metabolic tests the origin could not be identified. Read More

Thromb Haemost 2020 Jul 30;120(7):1004-1024. Epub 2020 May 30.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.

Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Read More

J Cosmet Dermatol 2020 May 28. Epub 2020 May 28.

Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Background: Reconstruction of upper labial myomucosal defects is surgically challenging.

Aims: We evaluated whether central defects could be repaired using bilateral, buccinator myomucosal advancement flaps (b-BMAFs).

Methods: We evaluated five patients with early-stage, minor salivary gland mucoepidermoid carcinomas (low-grade [n = 2], intermediate-grade [n = 2], and high-grade [n = 1]) who underwent central, upper labial myomucosal reconstruction using b-BMAFs after cancer ablation. Read More

Cleft Palate Craniofac J 2020 May 28:1055665620926348. Epub 2020 May 28.

Univ. Lille, CHU Lille, INSERM, Oral and Maxillofacial Surgery Department, U1008-Controlled Drug Delivery Systems and Biomaterial, Lille, France.

Parental prenatal counseling is of paramount significance since parents often experience an emotional crisis with feelings of disappointment and helplessness. Three-dimensional (3D) printed model of the unborn child's face presenting with cleft lip and palate, based on ultrasonographic information, could be used to provide visual 3D information, further enhancing the prospective parent's comprehension of their unborn child's pathology and morphology, helping them to be psychologically prepared and improving the communication with the caretaking team. Prospective parents appreciate if prenatal counseling is available with the most detailed information as well as additional resources. Read More

Surg Laparosc Endosc Percutan Tech 2020 May 26. Epub 2020 May 26.

Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, Jilin Province, People's Republic of China.

Background: Mental nerve (MN) injuries are reported during transoral endoscopic thyroidectomy vestibular approach. Effect of trocar insertion and position on MN are examined in the present study.

Materials And Methods: Ten millimeter incision was made at the center of the lower lip oral vestibule. Read More

Vet Pathol 2020 Jul 26;57(4):550-553. Epub 2020 May 26.

Friedrich-Loeffler-Institute, Greifswald-Insel Riems, Germany.

Infection of small ruminants with peste des petits ruminants virus (PPRV) and goatpox virus (GTPV) are endemic and can have devastating economic consequences in Asia and Africa. Co-infection with these viruses have recently been reported in goats and sheep in Nigeria. In this study, we evaluated samples from the lips of a red Sokoto goat, and describe co-infection of keratinocytes with PPRV and GTPV using histopathology and transmission electron microscopy. Read More

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

Unidad de Inmunología e Histocompatibilidad, Hospital Dr. Carlos G. Durand, Buenos Aires, Argentina.

Background: Common Variable Immunodeficiency (CVID) is characterized by an impaired antibody production and a higher susceptibility to encapsulated bacterial infections. Lung disease is considered to be the most important cause of morbidity and mortality.

Methods: We analyzed clinical, radiological and functional characteristics in 80 patients with CVID assisted in the Unidad Inmunologia e Histocompatibilidad at Durand Hospital from 1982 to 2018. Read More

Am J Med Genet A 2020 Jul 22;182(7):1812-1814. Epub 2020 May 22.

Division of Maternal Fetal Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.

3MC syndromes are rare heterogeneous autosomal recessive conditions previously designated as Mingarelli, Malpuech, Michels, and Carnevale syndromes, characterized by dysmorphic facial features, facial clefts, growth restriction, and intellectual disability. 3MC is secondary to mutations in the MASP1, MASP3, COLEC11, and COLEC10 genes. The number of patients with 3MC syndrome with known mutations in the COLEC11 or MASP1 is, to date, less than 50. Read More

Cells 2020 May 16;9(5). Epub 2020 May 16.

Department of Experimental and Clinical Medicine and Center of Excellence "DENOthe", University of Florence, 50134 Florence, Italy.

In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism has also been proposed. Human and animal models of NASH have been associated with elevated levels of long chain ceramides and pro-apoptotic sphingolipid metabolites, implicated in regulating fatty acid oxidation and inflammation. Read More

Int J Nanomedicine 2020 23;15:2841-2858. Epub 2020 Apr 23.

School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.

Introduction: Osthole (Ost) is a coumarin compound that strengthens hippocampal neurons and neural stem cells against Aβ oligomer-induced neurotoxicity in mice, and is a potential drug for the treatment of Alzheimer's disease (AD). However, the effectiveness of the drug is limited by its solubility and bioavailability, as well as by the low permeability of the blood-brain barrier (BBB). In this study, a kind of transferrin-modified Ost liposomes (Tf-Ost-Lip) was constructed, which could improve the bioavailability and enhance brain targeting. Read More

Otolaryngol Head Neck Surg 2020 May 19:194599820918855. Epub 2020 May 19.

Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

Objective: To examine the microRNA (miRNA) expression profile of cutaneous squamous cell carcinoma (cSCC) tumors from aggressive head and neck locations compared with nonaggressive anatomic sites and normal controls.

Study Design: Retrospective analysis of miRNA expression.

Setting: Tertiary care center. Read More

Int J Surg Case Rep 2020 11;70:96-100. Epub 2020 May 11.

Department of Oral and Maxillo-Facial Surgery, Cambridge University Hospitals, Hills Road, Cambridge, CB2 0QQ, United Kingdom. Electronic address:

Introduction: Renal cell carcinoma (RCC) is the most common malignant tumour of the kidney. It usually presents in an occult manner, rarely with the classical triad of haematuria, abdominal mass and abdominal pain. Up to a third of patients have metastasis on presentation and only a few case reports have involved the mandible. Read More

Cureus 2020 Apr 13;12(4):e7662. Epub 2020 Apr 13.

Allergy and Immunology, Rutgers New Jersey Medical School, Newark, USA.

This case report represents a rare life-threatening hypersensitivity reaction of tocilizumab drug when it is used to treat giant cell arteritis. An elderly female with history of bilateral giant cell arteritis with anterior ischemic optic neuropathy of the right eye was started on tocilizumab after developing glucocorticoid-related complications. She received one month of the tocilizumab therapy along with the prednisone taper. Read More

Med Oral Patol Oral Cir Bucal 2020 Jul 1;25(4):e468-e473. Epub 2020 Jul 1.

Faculdade de Odontologia UFMG Department of Oral Surgery and Pathology Av. Antônio Carlos, 6627 sala 3204, Pampulha Belo Horizonte, Minas Gerais, Brasil, 31270-901

Background: This study compared three different concentrations of EO (1.25%, 2.5% and 5%) for the treatment of oral vascular anomalies (OVAs). Read More

Cancer Med 2020 Jul 7;9(13):4490-4494. Epub 2020 May 7.

Departments of Pathology & Laboratory Medicine and Paediatrics, University of Calgary, Alberta Children's Hospital, Calgary, Alberta, Canada.

The roots of precision cancer therapy began at the Mayo Clinic in 1914 when surgical pathologist Albert C. Broders began collecting data showing that cancers of the same histologic type behaved differently. In March 1920, based upon 6 years of clinical follow-up, Broders published his first paper, utilizing data from over 500 cases of squamous cell carcinoma of the lip that he had blindly divided into four histologic grades based upon degree of differentiation, showing that numerical tumor "grading" allowed him to predict patient prognosis. Read More

Sisli Etfal Hastan Tip Bul 2019 26;53(3):256-262. Epub 2019 Aug 26.

Department of Plastic Reconstructive and Aesthetic Surgery, Uludag Faculty of Medicine, Bursa, Turkey.

Objectives: Reconstruction of wide lower lip defects is still a challenging subject in terms of obtaining functional and aesthetically acceptable results. Lower lip reconstruction with depressor anguli oris muscle was first described by Tobin in 1983. Since the sensory innervation of this composite muscle flap is provided by the mental nerve, it has been advocated that the mental nerve should be preserve during flap elevation. Read More

Respir Med Case Rep 2020 18;30:101059. Epub 2020 Apr 18.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Lymphoid interstitial pneumonia (LIP) is categorized as a rare form of interstitial lung disease. Most cases are associated with autoimmune disease.

Case Report: A 78-year-old male with Crohn's disease, presented with progressive dyspnea and dry cough for few weeks. Read More

Dentomaxillofac Radiol 2020 May 29:20190318. Epub 2020 May 29.

Diagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Objectives: Ultra-high frequency ultrasound (UHFUS) is a recently developed diagnostic technique involving the use of ultrasound frequencies up to 70 MHz, allowing to obtain 30 µm resolution of targets located within 1 cm from the surface. Oral mucosa can be affected by diverse pathological conditions, which are currently investigated by means of clinical examination. In this scenario, intraoral UHFUS can provide additional information and support clinical assessment of oral mucosa. Read More

Int J Pediatr Otorhinolaryngol 2020 Jul 21;134:110052. Epub 2020 Apr 21.

Department of Rehabilitation Sciences, Ghent University, Corneel Heymanslaan 10, 2P1, 9000, Gent, Belgium; Faculty of Humanities, Department of Speech-Language Pathology and Audiology, University of Pretoria, Lynnwood Road Hillcrest, Pretoria, South Africa.

Objectives: workshops and specialized training programs are often inaccessible for speech and language pathologists (SLPs) based in resource-limited countries given the lack of supply, the long travel distances and the excessive participation fees. To stimulate life-long learning opportunities for all, this study described and measured the effect of a free, two-day cleft care workshop for SLPs in Uganda. The workshop included different topics related to the assessment and treatment of children with a cleft of the palate with or without a cleft of the lip (CP ± L). Read More

Photodiagnosis Photodyn Ther 2020 Jun 30;30:101798. Epub 2020 Apr 30.

Department of Dermatology, Maoming People's Hospital, Maoming, Guangdong, China. Electronic address:

Background: Keratoacanthoma (KA) is a cutaneous neoplasm, which is similar to squamous cell carcinoma (SCC) clinically, cytologically, and histopathologically. Surgical resection is the first choice for treating KA, but it may be impractical when a KA is located in a cosmetically sensitive area.

Observation: We describe a patient with a nodule on the right upper lip. Read More

CNS Spectr 2020 Apr;25(2):266

Smell and Taste Treatment and Research Foundation, Chicago, Illinois.

Study Objective: Specific taste quality deficits in ALS has not heretofore been described.

Method: Case Study: A 71 year old right handed female presented with a two year course of progressive reduction in strength in her hands, arms and legs with difficulty tying shoe laces, opening jars, writing and walking. She described nocturnal muscle spasms involving all extremities. Read More

Am J Dermatopathol 2020 Apr 21. Epub 2020 Apr 21.

Department of Cellular Pathology, Hospital Universitario El Bierzo, Ponferrada, Spain.

Syphilis is a sexually transmitted disease caused by Treponema pallidum. The primary stage of the disease (the chancre) mainly involves the genital areas. Extragenital areas are involved in 5%-14% of cases, many of which occur in the oral cavity. Read More

Med Arch 2020 Feb;74(1):65-68

Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram, Chennai, India.

Introduction: Allergic reactions can manifest in various forms ranging from mild, almost unnoticeable reactions to life threatening anaphylaxis. Stomatitis venenata or contact stomatitis is described as a contact allergy of the oral mucosa which can occur due to repeated contact with the causative agent. Dental and cosmetic products, dental materials and dental therapeutic agents are the common allergens of the oral cavity. Read More

Hua Xi Kou Qiang Yi Xue Za Zhi 2020 Apr;38(2):149-154

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Objective: This research aims to collect speech samples from patients with cleft palate, establish a mandarin-based database of cleft palate speech after sample analysis and classification, and provide a reference for the diagnosis of hypernasal or cleft palate, clinical education, and standard training for professional speech therapists and related research.

Methods: A total of 768 speech samples were collected from patients and volunteers from the Speech Therapy Center, West China Hospital of Stomatology, between May 2016 and March 2018. These samples were edited and categoried before being saved into the cleft lip and palate biologic information database. Read More

J Am Coll Cardiol 2020 06 17;75(23):2950-2973. Epub 2020 Apr 17.

Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool, United Kingdom; Aalborg University, Aalborg, Denmark.

Coronavirus disease-2019 (COVID-19), a viral respiratory illness caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), may predispose patients to thrombotic disease, both in the venous and arterial circulations, because of excessive inflammation, platelet activation, endothelial dysfunction, and stasis. In addition, many patients receiving antithrombotic therapy for thrombotic disease may develop COVID-19, which can have implications for choice, dosing, and laboratory monitoring of antithrombotic therapy. Moreover, during a time with much focus on COVID-19, it is critical to consider how to optimize the available technology to care for patients without COVID-19 who have thrombotic disease. Read More

Cleft Palate Craniofac J 2020 Apr 15:1055665620919312. Epub 2020 Apr 15.

Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Idi-Araba, Nigeria.

Objective: To carry out a survey of breastfeeding practices and related challenges among mothers with orofacial cleft babies attending the cleft clinic of a tertiary health institution.

Methodology: This was a cross-sectional descriptive study using an interviewer-administered questionnaire. Sample population was all mothers of babies aged between 1 and 18 months with nonsyndromic orofacial clefts attending the cleft clinic of a tertiary health institution in Nigeria. Read More

Heliyon 2020 Apr 6;6(4):e03746. Epub 2020 Apr 6.

Department of Pathology, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan, China.

Among several types of ovarian tumors, Sertoli-Leydig cell tumors are considered significantly rare, accounting for less than 1% of all primary ovarian tumors. Hirsutism caused by ovarian tumors accounts for approximately 1% of all cases of hirsutism. We report a case of a woman with a ovarian Sertoli-Leydig cell tumor who presented with hirsutism. Read More

Acta Paediatr 2020 Apr 11. Epub 2020 Apr 11.

Institute of Neuroscience and Physiology, Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Aim: The aim of this study was to investigate language ability in internationally adopted children aged 7-8 years with and without a unilateral cleft lip and palate.

Methods: We compared 27 internationally adopted children with a unilateral cleft lip and palate, adopted from China, with a group of 29 children without a cleft lip and palate, adopted from different countries. Participants were recruited from two cleft lip and palate teams in Sweden and through adoption organisations. Read More

Life Sci 2020 Jul 7;252:117646. Epub 2020 Apr 7.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells causing resistance to immunotherapies in cancer tumors. In the current study, various immunogenic and therapeutic features of the combination therapies with non-liposomal Doxorubicin (Dox) and the E75 immunogenic peptide (Pep), derived from the human epidermal receptor-2 (HER-2), are investigated in parallel with their liposomal formulations (Lip-Dox (Doxil®) and Lip-Pep). Therefore, triple injection doses of Lip-Pep were preceded with Dox and Lip-Dox injections in TUBO/breast tumor-bearing BALB/c mice. Read More

Head Neck Pathol 2020 Apr 8. Epub 2020 Apr 8.

Department of Diagnostic Sciences, Texas A&M University College of Dentistry, Dallas, USA.

Plexiform schwannoma represents an unusual schwannoma variant, characterized by multinodular growth grossly and/or microscopically. A review of the English-language literature reveals only 28 previously reported cases involving the oral cavity, and herein we present 8 additional cases. Among these 36 patients, the average age at diagnosis was 28 years (range 5 to 62 years), with a female-to-male ratio of 1. Read More