10,643 results match your criteria Biopsy Lip


Immunohistochemical evaluation of HLA-G and FoxP3+ T regulatory cells in oral cavity and lower lip squamous cell carcinomas.

Braz Oral Res 2019 11;33:e020. Epub 2019 Apr 11.

Universidade Federal do Rio Grande do Norte - UFRN, Department of Clinical Analysis and Toxicology, Natal, RN, Brazil.

Human Leukocyte Antigen G (HLA-G) is a molecule involved in the tumor immunosuppression and also in the generation of regulatory T (Treg) cells, thus leading to evasion to the immune system host, and consequently, contributing to tumor progression in several cancers. The aim of this study was to evaluate the immunoexpression of HLA-G by tumor cells and FoxP3+ Treg cells in 25 oral tongue squamous cell carcinomas (SCCs) and 25 lower lip SCCs and analyze their relationship with clinical parameters. HLA-G expression was higher in oral tongue SCCs than in lower lip SCCs. Read More

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http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0020DOI Listing

Low-level laser as a complementary therapy in orofacial granulomatosis management: a case report.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Mar 1. Epub 2019 Mar 1.

Department of Stomatology and Oral and Maxillofacial Surgery, Hospital Metropolitano Odilon Behrens (HMOB), Belo Horizonte, MG, Brazil.

Orofacial granulomatosis (OFG) is a chronic inflammatory disease that typically affects the soft tissues of the orofacial region. The most common clinical manifestation of OFG is lip swelling, which may be associated with intrabuccal ulcerations and increased growth of the gingiva and mucosa, as well as cutaneous erythema and facial edema. The treatment for OFG is challenging, and sometimes considered unsatisfactory. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.02.024DOI Listing

Development and Validation of Nomogram for Prediction of Malignant Transformation in Oral Leukoplakia: A Large-Scale Cohort Study.

J Oral Pathol Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

Objectives: Oral leukoplakia (OL) is the well-known disorder of oral mucosa, which has potential to be malignant and can lead to squamous cell carcinoma (OSCC). In the following study, we developed a comprehensive nomogram for predicting the malignant progression of OL, based on analysis of clinicopathological variables.

Materials And Methods: A retrospective analysis of patients diagnosed with OL was performed between 1998 and 2017 at the Peking University School and Hospital of Stomatology. Read More

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http://dx.doi.org/10.1111/jop.12862DOI Listing

Superficial radiotherapy for non-melanoma skin cancer of the lip: a 44-year Italian experience.

J Dermatolog Treat 2019 Apr 11:1-17. Epub 2019 Apr 11.

a Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Sezione Fotoradioterapia , UO Dermatologia , Milan , Italy.

Background: Radiotherapy is a valuable therapeutic option for the treatment of non-melanoma skin cancer (NMSC) in the ageing population, in non-surgical candidates, or when the tumour is extensive or localised in a cosmetically-sensitive area such as the lips.

Objective: We report our 44-year experience in treating basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the vermilion lip using superficial radiotherapy.

Methods: Forty-seven patients with biopsy-proven BCC or SCC of the lip were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605137DOI Listing
April 2019
5 Reads

Glomus Tumor of the Oral Cavity: Report of a Rare Case and Literature Review.

Braz Dent J 2019 Mar-Apr;30(2):185-190. Epub 2019 Apr 4.

School of Dentistry, Oral Pathology Section, Department of Clinical and Preventive Dentistry, UFPE - Universidade Federal de Pernambuco, Recife, PE, Brazil.

Glomus tumor is a benign neoplasm composed of a perivascular proliferation of glomic cells that resembles the normal glomus body. Usually, it appears as a solitary, symptomatic small blue-red nodule, located in the deep dermis or subcutis of upper or lower extremities of young to middle-aged adults. Cases affecting the oral cavity are very rare, with only 23 well-documented cases reported in the English-language literature. Read More

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http://dx.doi.org/10.1590/0103-6440201902222DOI Listing
April 2019
6 Reads

Giant arteriovenous malformation of the face and upper lip.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):32-35

Department of Oral Pathology, Navodaya Dental College and Hospital, Raichur, Karnataka, India.

A 35-year-old male patient reported with the chief complaint of a large swelling in the right side of the upper lip. The lesion measured 6.5 cm measuring from the infraorbital region to the lower border of mandible on the right side of the face and 7. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_185_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421929PMC
February 2019
1 Read

Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer.

Autops Case Rep 2019 Apr-Jun;9(2):e2018075. Epub 2019 Mar 22.

Federal University of Minas Gerais (UFMG), Oral Surgery and Pathology Department, School of Dentistry. Belo Horizonte, MG, Brazil.

Plasma cell cheilitis (PCC) is an inflammatory disorder of unknown etiology that affects the lip. It is characterized histologically by a dense infiltrate of plasma cells with a variety of clinical features. The response to different therapeutic modalities is controversial, especially regarding the effectiveness of corticosteroids. Read More

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http://dx.doi.org/10.4322/acr.2018.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433141PMC
March 2019
1 Read

Acinetobacter baumannii orofacial cellulitis: report of 2 cases.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

Acinetobacter baumannii infection of skin and soft tissues is uncommon and usually associated with trauma. The present report describes 2 pediatric cases of cellulitis in the orofacial region, caused by A. baumannii infection with a fatal outcome. Read More

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http://dx.doi.org/10.1016/j.oooo.2019.02.012DOI Listing
February 2019

Magnetic resonance imaging and proton magnetic resonance spectroscopy for differentiating between enhanced gliomas and malignant lymphomas.

World Neurosurg 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.

Objective: Although the treatment strategies for malignant lymphomas and gliomas differ, it is usually difficult to preoperatively distinguish between the two. Magnetic resonance spectroscopy (MRS) was recently reported to be useful for preoperative diagnoses; however, MRS data analysis using LCModel, which is a quantitative and objective method, was performed in only a few of the existing reports.

Methods: The clinical characteristics, conventional magnetic resonance imaging findings and MRS parameters using LCModel were evaluated to identify the factors that can help distinguish between malignant lymphomas and enhanced gliomas. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.261DOI Listing
April 2019
6 Reads

Pain Reduction in Extensive Apical Surgery of the Anterior Maxilla: A Comparative Clinical Study.

J Oral Maxillofac Surg 2019 Apr 29;77(4):715-720. Epub 2018 Sep 29.

Assistant Lecturer, Department of Pedodontics and Preventive Dentistry, Dental Teaching Hospital, College of Dentistry, University of Baghdad, Baghdad, Iraq.

Purpose: The purpose of this study was to compare the outcomes of 2 different anesthetic techniques (local infiltration vs infraorbital nerve block) for eliminating pain during apical surgeries that are associated with extensive periapical pathology in the anterior maxilla.

Materials And Methods: Patients were randomly divided into 2 groups: patients in group I were anesthetized labially by local infiltration injections, whereas those in group II received a single infraorbital nerve block. Palatal injections were given for the 2 groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391183110
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http://dx.doi.org/10.1016/j.joms.2018.09.029DOI Listing
April 2019
3 Reads

Hard- and soft-tissue symmetry comparison in patients with Class III malocclusion.

Am J Orthod Dentofacial Orthop 2019 Apr;155(4):509-522

Department of Orthodontics, Gülhane Faculty of Dentistry, Sağlık Bilimleri University, Etlik, Ankara, Turkey.

Objective: Our aim was to describe hard- and soft-tissue asymmetry in people who have a skeletal Class III malocclusion, and to compare with those without asymmetry. We also performed a regional analysis of a possible correlation between facial soft- and hard-tissue asymmetries.

Methods: This retrospective study was performed with the use of the computed tomographic scans of 60 subjects. Read More

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http://dx.doi.org/10.1016/j.ajodo.2018.05.021DOI Listing

Voxel-based micro-finite element analysis of dental implants in a human cadaveric mandible: Tissue modulus assignment and sensitivity analyses.

J Mech Behav Biomed Mater 2019 Mar 13;94:229-237. Epub 2019 Mar 13.

Department of Mechanical Engineering, Penn State University, University Park, PA, United States. Electronic address:

The success of dental implant treatment is related to the complex 3-dimensional (3D) biomechanics of the implant-bone interaction. In this work, 3D numerical models are built based on micro X-ray computed tomography (micro-CT) images of a cadaveric mandible specimen with implants placed in it. The simulation results show that the computed strain values in bone are sensitive to the uncertainties in trabecular tissue modulus and fairly insensitive to the modulus of implants and teeth and the detailed geometry of the fixed boundary condition. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.03.008DOI Listing

Serious complication as a result of lip augmentation with vitamin E.

J Cosmet Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Nowadays lip augmentation with FDA-approved fillers is becoming popular. However, because of financial concerns many patients seek for unregistered materials. Here, we report two cases who use vitamin E for lip augmentation. Read More

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http://dx.doi.org/10.1111/jocd.12926DOI Listing

Cleft Rhinoplasty Study and Evolution.

J Craniofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Division of Plastic Surgery, Department of Surgery, University of Kentucky, Lexington, KY.

Background: Most patients with a cleft lip will have a cleft lip nasal deformity. The nasal deformities are complex and are difficult to surgically correct as a result of the anatomical issues and deficiencies. In this study, the authors analyzed and reviewed nasal pathology and surgical maneuvers in patients with cleft lip nasal deformity treated by the senior author over the past 15 years. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005304DOI Listing
March 2019
1 Read

The nasolabial subcutaneous pedicle flap for lower-lip defect reconstruction.

J Dent Sci 2018 Jun 20;13(2):177-178. Epub 2017 Oct 20.

Division of Oral and Maxillofacial Surgery, Department of Dentistry, Tri-Service General Hospital, Taiwan, ROC.

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http://dx.doi.org/10.1016/j.jds.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388862PMC
June 2018
3 Reads

Alveolar soft-part sarcoma of the masseter and mandibular ramus: Report of a case and review of the literature.

J Dent Sci 2018 Mar 28;13(1):75-79. Epub 2013 Jun 28.

Oral Pathology Department, Faculty of Dentistry, Universidad Andrés Bello, Viña del Mar, Chile.

Alveolar soft-part sarcomas are clinically and morphologically distinct soft-tissue sarcomas, with an unknown histogenesis. When the tumors affect the region of the head and neck, they are often located in the orbit and tongue. We report a case of an alveolar soft-part sarcoma in the left masseter of a 28-year-old female. Read More

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http://dx.doi.org/10.1016/j.jds.2013.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388804PMC

In Silico and In Vivo Studies Detect Functional Repair Mechanisms in a Volumetric Muscle Loss Injury.

Tissue Eng Part A 2019 Mar 18. Epub 2019 Mar 18.

1 Department of Biomedical Engineering and University of Virginia, Charlottesville, Virginia.

Impact Statement: Despite medical advances, volumetric muscle loss (VML) injuries to craniofacial muscles represent an unmet clinical need. We report an implantable tissue-engineered construct that leads to substantial tissue regeneration and functional recovery in a preclinical model of VML injury that is dimensionally relevant to unilateral cleft lip repair, and a series of corresponding computational models that provide biomechanical insight into mechanism(s) responsible for the VML-induced functional deficits and recovery following tissue-engineered muscle repair implantation. This unique combined approach represents a critical first step toward establishing a crucial biomechanical basis for the development of efficacious regenerative technologies, considering the spectrum of VML injuries. Read More

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http://dx.doi.org/10.1089/ten.tea.2018.0280DOI Listing

MTHFR C677T polymorphism and risk of nonsyndromic cleft lip with or without cleft palate in the Moroccan population.

Appl Clin Genet 2019 7;12:51-54. Epub 2019 Mar 7.

Laboratory of Medical Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy Casablanca, University Hassan II, Casablanca, Morocco,

Background: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common craniofacial malformations observed. Several studies suggest that the decrease in folate has been associated with a higher risk of NSCL/P. The present study aimed to determine the association of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism gene with the occurrence of NSCL/P in the Moroccan population. Read More

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http://dx.doi.org/10.2147/TACG.S194166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410759PMC

Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: an experience from the Egyptian National Cancer Institute.

J Investig Med 2019 Mar 13. Epub 2019 Mar 13.

Surgical Pathology, National Cancer Institute, Cairo, Egypt.

Human papilloma virus (HPV) is now a well-known risk factor for head and neck cancer besides smoking and alcohol. Most studies mentioned that patients affected with high-risk HPV cancers have a better outcome, and many clinical trials are trying to prove that such group of patients can receive a different and less aggressive treatment than the HPV-negative group. Although such field has received great interest within different countries and continents, African and Egyptian populations are not yet well studied within the literature. Read More

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http://dx.doi.org/10.1136/jim-2018-000968DOI Listing
March 2019
1 Read

Oral mucosal complications in orthodontic treatment.

Minerva Stomatol 2019 Apr;68(2):84-88

Department of Orthodontics, Vita-Salute San Raffaele University, Milan, Italy -

Background: Orthodontic therapy is used to solve numerous oral problems, but the use of fixed oral devices can also impact negatively the oral cavity, if the treatment is not steadily under control. The aim of this study is to evaluate tooth, bone and soft tissues lesions due to the presence of fixed orthodontic appliances.

Methods: One hundred patients with fixed orthodontic appliances were included in the study. Read More

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https://www.minervamedica.it/index2.php?show=R18Y2019N02A008
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http://dx.doi.org/10.23736/S0026-4970.18.04127-4DOI Listing
April 2019
5 Reads

Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability.

Authors:
Benjamin Cogné Sophie Ehresmann Eliane Beauregard-Lacroix Justine Rousseau Thomas Besnard Thomas Garcia Slavé Petrovski Shiri Avni Kirsty McWalter Patrick R Blackburn Stephan J Sanders Kévin Uguen Jacqueline Harris Julie S Cohen Moira Blyth Anna Lehman Jonathan Berg Mindy H Li Usha Kini Shelagh Joss Charlotte von der Lippe Christopher T Gordon Jennifer B Humberson Laurie Robak Daryl A Scott Vernon R Sutton Cara M Skraban Jennifer J Johnston Annapurna Poduri Magnus Nordenskjöld Vandana Shashi Erica H Gerkes Ernie M H F Bongers Christian Gilissen Yuri A Zarate Malin Kvarnung Kevin P Lally Peggy A Kulch Brina Daniels Andres Hernandez-Garcia Nicholas Stong Julie McGaughran Kyle Retterer Kristian Tveten Jennifer Sullivan Madeleine R Geisheker Asbjorg Stray-Pedersen Jennifer M Tarpinian Eric W Klee Julie C Sapp Jacob Zyskind Øystein L Holla Emma Bedoukian Francesca Filippini Anne Guimier Arnaud Picard Øyvind L Busk Jaya Punetha Rolph Pfundt Anna Lindstrand Ann Nordgren Fayth Kalb Megha Desai Ashley Harmon Ebanks Shalini N Jhangiani Tammie Dewan Zeynep H Coban Akdemir Aida Telegrafi Elaine H Zackai Amber Begtrup Xiaofei Song Annick Toutain Ingrid M Wentzensen Sylvie Odent Dominique Bonneau Xénia Latypova Wallid Deb Sylvia Redon Frédéric Bilan Marine Legendre Caitlin Troyer Kerri Whitlock Oana Caluseriu Marine I Murphree Pavel N Pichurin Katherine Agre Ralitza Gavrilova Tuula Rinne Meredith Park Catherine Shain Erin L Heinzen Rui Xiao Jeanne Amiel Stanislas Lyonnet Bertrand Isidor Leslie G Biesecker Dan Lowenstein Jennifer E Posey Anne-Sophie Denommé-Pichon Claude Férec Xiang-Jiao Yang Jill A Rosenfeld Brigitte Gilbert-Dussardier Séverine Audebert-Bellanger Richard Redon Holly A F Stessman Christoffer Nellaker Yaping Yang James R Lupski David B Goldstein Evan E Eichler Francois Bolduc Stéphane Bézieau Sébastien Küry Philippe M Campeau

Am J Hum Genet 2019 Mar 28;104(3):530-541. Epub 2019 Feb 28.

Centre Hospitalier Universitaire Sainte-Justine Research Centre, University of Montreal, Montreal, QC H3T 1C5, Canada; Department of Pediatrics, University of Montreal, Montreal, QC H3T1J4, Canada. Electronic address:

Acetylation of the lysine residues in histones and other DNA-binding proteins plays a major role in regulation of eukaryotic gene expression. This process is controlled by histone acetyltransferases (HATs/KATs) found in multiprotein complexes that are recruited to chromatin by the scaffolding subunit transformation/transcription domain-associated protein (TRRAP). TRRAP is evolutionarily conserved and is among the top five genes intolerant to missense variation. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407527PMC
March 2019
8 Reads
10.931 Impact Factor

Clinicopathologic Trends in Pediatric Oral Biopsies: A 10-Year Institutional Archival Study.

Int J Appl Basic Med Res 2019 Jan-Mar;9(1):44-48

Department of Microbiology, A B Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangalore, Karnataka, India.

Aim: The aim of this study is to determine the clinicopathologic trends in oral pathological biopsies in children aged 14 years and below received for histopathological diagnosis in the institution.

Materials And Methods: The archives of the Department of Oral Pathology and Microbiology were retrospectively analyzed. Biopsy records of all oral lesions from pediatric patients, aged 0-14 years, in the files of the Department of Oral Pathology and Microbiology, A B Shetty Memorial Institute of Dental Sciences, Mangalore, DK, from 2007 to 2017 were considered. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_253_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385541PMC

Pleomorphic Adenoma of the Upper Lip: A Case Report.

Saudi J Med Med Sci 2018 Jan-Apr;6(1):32-35. Epub 2017 Dec 14.

Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

Pleomorphic adenoma is the most frequently encountered benign mixed tumor of the minor salivary gland and usually presents in the parotid; however, in the minor salivary gland, it is more common in the palate. Tumors of the minor salivary glands are uncommon, with the most common intraoral site reported being the hard and soft palate owing to the preponderance of minor salivary glands in this region followed by the lips. Pleomorphic adenoma arising from minor salivary glands of the lips tends to occur at an earlier age than it does at other sites. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_109_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196673PMC
December 2017
1 Read

The stem cell markers expression CD44v6 and podoplanin in lip cancer: clinical significance.

Virchows Arch 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil.

This study aimed to analyze the immunoexpression of cancer stem cell markers, CD44v6, and podoplanin in 91 patients with lip squamous cell carcinomas (LSCC). The immunostaining of podoplanin and CD44v6 was evaluated in ten high-power fields (× 400 magnification) at the invasive front of LSCC, using a semi-quantitative score method. Chi-square test or Fisher's exact test was used to verify the association of podoplanin and CD44v6 expressions with clinicopathologic variables. Read More

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http://dx.doi.org/10.1007/s00428-019-02539-3DOI Listing
February 2019
3 Reads

Feeding difficulties in infants with unrepaired cleft lip and palate and HIV-exposure.

Afr Health Sci 2018 Dec;18(4):1098-1108

Department of Speech-Language Pathology and Audiology, Faculty of Humanities, University of Pretoria Private Bag X20, Hatfield 0028.

Background: There is limited description of the feeding characteristics of infants with unrepaired cleft lip and palate, exposed to HIV, but not necessarily infected.

Objective: To compare the feeding characteristics of infants with unrepaired cleft lip and palate and HIV-exposure, to infants with unrepaired cleft lip and palate only.

Method: A two-group comparative design with a validated measure, the Neonatal Feeding Assessment Scale was used. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354895PMC
December 2018
1 Read

Nonsense variants in STAG2 result in distinct sex-dependent phenotypes.

J Hum Genet 2019 May 14;64(5):487-492. Epub 2019 Feb 14.

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

We herein report two individuals with novel nonsense mutations in STAG2 on Xq25, encoding stromal antigen 2, a component of the cohesion complex. A male fetus (Case 1) clinically presented with holoprosencephaly, cleft palate and lip, blepharophimosis, nasal bone absence, and hypolastic left heart by ultrasonography at 15 gestational weeks. Another female patient (Case 2) showed a distinct phenotype with white matter hypoplasia, cleft palate, developmental delay (DD), and intellectual disability (ID) at 7 years. Read More

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http://dx.doi.org/10.1038/s10038-019-0571-yDOI Listing
May 2019
1 Read
2.462 Impact Factor

Comparison of cheiloscopy, odontometric, and facial index for sex determination in forensic dentistry.

J Forensic Dent Sci 2018 May-Aug;10(2):88-91

Dental Consultant, Vellore, Tamil Nadu, India.

Background: The "gender determination" which is an important human identification procedure not only helps in establishing the biological profile from skeletal and dental remains but also in facial reconstruction of unidentified victims.

Aim: The aim of this study is to analyze predominant types of lip prints (cheiloscopy), accuracy of mandibular canine index (MCI) (odontometric), and facial index in the study population and to identify whether any correlation among the above parameters could help forensic dentistry in solving crimes.

Materials And Methods: A pilot study was conducted in 100 individuals, 50 males and 50 females aged between 20 and 25 years. Read More

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http://dx.doi.org/10.4103/jfo.jfds_102_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344791PMC
February 2019
1 Read

Assessment of Density of Neovascularization in Lower Lip Squamous Cell Carcinoma in Relation To Neoplasm Differentiation Grade in Patients with and without Neck Lymph Nodes Metastasis.

Open Access Maced J Med Sci 2019 Jan 3;7(1):19-23. Epub 2019 Jan 3.

Institute of Pathology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Squamous cell carcinoma (SCC) of the lower lip is a relatively rare carcinoma, with the incidence of 1 to 2%, but it is the most common carcinoma in the oral cavity accounting for 25-30% of all malignant oral tumours.

Aim: This study aimed to determine the role of neovascularisation in the process of tumour progression.

Methods: We analysed the surgical specimens obtained from 60 patients with squamous cell carcinoma (SCC) of the lower lip. Read More

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http://dx.doi.org/10.3889/oamjms.2019.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352486PMC
January 2019
1 Read

Nasal Parameters, Nostrils Shapes and Philtral Column Shape: A Morphometric Analysis in Nepalese Medical Undergraduate Students.

J Nepal Health Res Counc 2019 Jan 28;16(41):462-466. Epub 2019 Jan 28.

Department of Oral Pathology, KIST Medical College and Hospital, Imadole Kathmandu, Nepal.

Background: The nose is a pyramidal shaped structure situated in the midline of midface being attached to the facial skeleton. The shape, size and spatial location of the nose-philtrum-upper lip complex are important from aesthetic point of view. Hence, to study the nasal parameters, shape of nostril and philtrum among the undergraduate students remained as the main aim of this study. Read More

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January 2019
1 Read

New and known species of the genus Pungentus Thorne & Swanger, 1936 (Dorylaimida, Nordiidae) from Iran.

J Helminthol 2019 Feb 8:1-9. Epub 2019 Feb 8.

Department of Plant Pathology,Faculty of Agriculture,Tarbiat Modares University,Tehran,Iran.

This contribution provides morphological and molecular data for one new and one known species of the genus Pungentus. The first species, P. azarbaijanensis n. Read More

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http://dx.doi.org/10.1017/S0022149X18001232DOI Listing
February 2019

Oral tuberculosis mimicking a traumatic denture ulcer.

J Prosthet Dent 2019 Feb 26;121(2):225-228. Epub 2018 Oct 26.

Associate Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Tuberculosis (TB) of the oral cavity may be overlooked in the differential diagnosis of oral lesions and can be misdiagnosed and managed incorrectly. A 66-year-old man with complete dentures presented with a nonhealing mucosal ulcer in the upper lip. Despite the treatments performed by a local medical clinic, the ulcerative lesion on the denture-bearing area had not improved over 5 months. Read More

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http://dx.doi.org/10.1016/j.prosdent.2018.04.024DOI Listing
February 2019
2 Reads

Network-based identification of critical regulators as putative drivers of human cleft lip.

BMC Med Genomics 2019 Jan 31;12(Suppl 1):16. Epub 2019 Jan 31.

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St., Suite 820, Houston, TX, 77030, USA.

Background: Cleft lip (CL) is one of the most common congenital birth defects with complex etiology. While genome-wide association studies (GWAS) have made significant advances in our understanding of mutations and their related genes with potential involvement in the etiology of CL, it remains unknown how these genes are functionally regulated and interact with each other in lip development. Currently, identifying the disease-causing genes in human CL is urgently needed. Read More

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https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s12920-018-0458-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357351PMC
January 2019
7 Reads

Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil.

J Clin Exp Dent 2019 Jan 1;11(1):e62-e69. Epub 2019 Jan 1.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

Background: To investigate the prevalence of malignant and potentially malignant lesions of the lip in an oral pathology service and to compare these data with a literature review.

Material And Methods: A total of 3173 biopsy reports and histopathological records were analyzed. Cases with a histological diagnosis of actinic cheilitis (AC) with or without epithelial dysplasia, in situ carcinoma, or lip squamous cell carcinoma (LSCC) were included. Read More

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http://www.medicinaoral.com/medoralfree01/aop/55133.pdf
Publisher Site
http://dx.doi.org/10.4317/jced.55133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343992PMC
January 2019
8 Reads

Speech Phenotyping in Unaffected Family Members of Individuals With Nonsyndromic Cleft Lip With or Without Palate.

Cleft Palate Craniofac J 2019 Jan 29:1055665618823936. Epub 2019 Jan 29.

7 Plastic and Maxillofacial Surgery, Royal Children's Hospital, Parkville, VIC, Australia.

Objective:: Subclinical phenotypes of nonsyndromic cleft lip with or without cleft palate (CL ± P) may be identified from clinically "unaffected" relatives and could be associated with specific cleft-related gene mutations. It has been hypothesized that velopharyngeal insufficiency (VPI) may be a subclinical phenotype of interest in this population, but this has not been explored quantitatively with appropriate control cohorts. The aim of this case-control study was to compare VPI in at-risk clinically unaffected relatives of individuals with nonsyndromic CL ± P with a low-risk matched normative Australian cohort. Read More

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http://dx.doi.org/10.1177/1055665618823936DOI Listing
January 2019
13 Reads

Patterns of peripheral neuropathy in Sjogren's syndrome in a tertiary care hospital from South India.

Neurol India 2019 Jan-Feb;67(Supplement):S94-S99

Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Introduction: Sjogren's syndrome (SS) is a systemic autoimmune disease that apart from involving the exocrine glands can affect any organ. Involvement of the peripheral nervous system results in a wide spectrum of neuropathic manifestations.

Objective: To evaluate the clinico-electrophysiological patterns as well as pathological characteristics of neuropathy in SS patients presenting to a neuromuscular clinic in a tertiary hospital from South India. Read More

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http://dx.doi.org/10.4103/0028-3886.250714DOI Listing
January 2019
13 Reads
1.084 Impact Factor

Fludroxycortide cream as an alternative therapy for actinic cheilitis.

Clin Oral Investig 2019 Jan 23. Epub 2019 Jan 23.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Objectives: The objective of the study is to assess, by clinical follow-up, the efficacy of the dermatological cream Fludroxycortide 0.125 mg/g (Drenison®) in the treatment of actinic cheilitis (AC).

Material And Methods: Twenty-three patients diagnosed with AC participated in the study. Read More

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http://link.springer.com/10.1007/s00784-019-02823-1
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http://dx.doi.org/10.1007/s00784-019-02823-1DOI Listing
January 2019
7 Reads

A distinct neurodevelopmental syndrome with intellectual disability, autism spectrum disorder, characteristic facies, and macrocephaly is caused by defects in CHD8.

J Hum Genet 2019 Apr 22;64(4):271-280. Epub 2019 Jan 22.

College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar.

A decade ago, we described novel de novo submicroscopic deletions of chromosome 14q11.2 in three children with developmental delay, cognitive impairment, and similar dysmorphic features, including widely-spaced eyes, short nose with flat nasal bridge, long philtrum, prominent Cupid's bow of the upper lip, full lower lip, and auricular anomalies. We suggested that this constituted a new multiple congenital anomaly-intellectual disability syndrome due to defects in CHD8 and/or SUPT16H. Read More

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http://dx.doi.org/10.1038/s10038-019-0561-0DOI Listing
April 2019
1 Read
2.462 Impact Factor

Effect of the Visual Presentation of a Craniofacial Syndrome on Speech Intelligibility in Noise.

Cleft Palate Craniofac J 2019 Jan 22:1055665618825403. Epub 2019 Jan 22.

2 Department of Psychology, Montclair State University, Montclair, NJ, USA.

Objective:: Research has argued that a speaker's facial appearance can result in an "intelligibility cost" for the listener. The study investigated whether such an intelligibility cost exists for a visible repaired cleft lip and nasal asymmetry.

Setting:: University department. Read More

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http://journals.sagepub.com/doi/10.1177/1055665618825403
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http://dx.doi.org/10.1177/1055665618825403DOI Listing
January 2019
10 Reads

A Case Analysis on CT Guided Percutaneous Lung Puncture Biopsy of Lymphocyte Mesenchymal Pneumonia.

Comb Chem High Throughput Screen 2018 ;21(10):806-810

Department of Respiration, Jinhua Central Hospital, Zhejiang University Jinhua Hospital, Jinhua, Zhejiang 321000, China.

Objective: To explore the application and diagnostic value of high-resolution CT in the process of lymphocytic interstitial pneumonia clinical diagnosis, and analyze one case of CT-guided percutaneous lung biopsy lymphocytic interstitial pneumonia.

Methods: The medical record of a patient with lymphocyte interstitial pneumonia (LIP) who came to the clinic on 2014-04-22 were analyzed and summarized retrospectively.

Results: The patient was a 55 years old female farmer. Read More

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http://dx.doi.org/10.2174/1386207322666190122112025DOI Listing
January 2018
5 Reads

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.

Nat Commun 2019 01 21;10(1):353. Epub 2019 Jan 21.

Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from 46 primary human muscosal, 65 primary canine oral and 28 primary equine melanoma cases from mucosal sites. Analysis of these data reveals recurrently mutated driver genes shared between species such as NRAS, FAT4, PTPRJ, TP53 and PTEN, and pathogenic germline alleles of BRCA1, BRCA2 and TP53. Read More

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http://www.nature.com/articles/s41467-018-08081-1
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http://dx.doi.org/10.1038/s41467-018-08081-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341101PMC
January 2019
8 Reads

Activation of Human CD11b B1 B-Cells by -Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease.

Front Immunol 2018 4;9:3015. Epub 2019 Jan 4.

Laboratory of Cell-Cell Interactions, Instituto de Ciências Biológicas, Departamento de Morfologia, Belo Horizonte, Brazil.

B-cells mediate humoral adaptive immune response via the production of antibodies and cytokines, and by inducing T-cell activation. These functions can be attributed to distinct B-cell subpopulations. Infection with , the causative agent of Chagas disease, induces a polyclonal B-cell activation and lytic antibody production, critical for controlling parasitemia. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03015
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http://dx.doi.org/10.3389/fimmu.2018.03015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328447PMC
January 2019
31 Reads

Clinical spectrum and pleiotropic nature of germline mutations.

J Med Genet 2019 Apr 19;56(4):199-208. Epub 2019 Jan 19.

Epithelial Interactions in Cancer Department, Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal.

encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is involved in major cellular processes such as embryogenesis and maintenance of tissue architecture, it is no surprise that deleterious effects arise from its loss of function. E-cadherin is recognised as a tumour suppressor gene, and it is well established that genetic alterations cause diffuse gastric cancer and lobular breast cancer-the foremost manifestations of the hereditary diffuse gastric cancer syndrome. Read More

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105807
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http://dx.doi.org/10.1136/jmedgenet-2018-105807DOI Listing
April 2019
7 Reads

A Study on Drug-Induced Tardive Dyskinesia: Orofacial Musculature Involvement and Patient's Awareness.

J Orofac Sci 2018 Jul-Dec;10(2):86-95. Epub 2019 Jan 2.

Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Affiliated to the Tamil Nadu Dr. M.G.R. Medical University.

Objective: Schizophrenia is a psychiatric disorder that requires long-term treatment. Long-term antipsychotic treatment is often associated with the emergence of tardive dyskinesia (TD), the severity of which is measured by Abnormal Involuntary Movement Scale (AIMS). This study examined the relationship among TD, orofacial musculature activity, and patient's awareness of AIM. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333421PMC
January 2019
7 Reads

Ointment Pseudo-Cheilitis: A Disease Distinct from Factitial Cheilitis. A Series of 13 Patients from São Paulo, Brazil.

J Cutan Med Surg 2019 Jan 17:1203475418825112. Epub 2019 Jan 17.

3 Department of Pathology, Dental School, University of São Paulo, Brazil.

Background:: The terms exfoliative cheilitis, factitial cheilitis, and morsicatio labiorum are used to describe self-inflicted lesions of the lip.

Objective:: Here we report and analyze clinical, pathological, and therapeutic data on 13 patients with a form of factitial cheilitis that we believe should be considered a separate entity.

Results:: Eight patients were male and 5 patients were female. Read More

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http://dx.doi.org/10.1177/1203475418825112DOI Listing
January 2019
16 Reads

Heritability and correlation of lip print, palm print, fingerprint pattern and blood group in twin population.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):451

Department of Oral Pathology and Microbiology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India.

Background: Twins are similar in many ways owing to the genetical and environmental factors. However, still, there are certain things that are not similar among them, and this is the challenge for personal identification among the twins.

Objectives: Our present study aimed to know and assess the similarities and differences present between the monozygotic (identical) and dizygotic (fraternal) twins in relation to lip prints, palm prints, fingerprints and blood group and to evaluate their heritability among parents and their offspring. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_216_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306610PMC
January 2019
1 Read

Benign chondroid syringoma affecting the upper lip: Report of a rare case and review of literature.

J Oral Maxillofac Pathol 2018 Sep-Dec;22(3):401-405

Department of Conservative Dentistry and Endodontics, Dental College, Regional Institute of Medical Sciences, Imphal, Manipur, India.

Chondroid syringoma (CS) (mixed tumor of the skin) is a rare neoplasm of the sweat glands, which presents itself as a slow-growing, painless, nonulcerated, subcutaneous or intracutaneous mass often occurring in the head and neck region. The clinician may miss the diagnosis of this lesion due to its rarity. CS should be considered in the differential diagnosis of any subcutaneous nodules, especially in the head and neck region. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_35_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306603PMC
January 2019
4 Reads

A new species of the genus Eudorylaimus Andrássy, 1959 (Nematoda: (Dorylaimida: Qudsianematidae) associated with Picea crassifolia in China.

Zootaxa 2018 Dec 3;4526(4):576-588. Epub 2018 Dec 3.

Lab of Plant Nematology/Research Center of Nematodes of Plant Quarantine, Department of Plant Pathology/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Agriculture, South China Agricultural University, Guangzhou, Guangdong, China Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, Guangdong 510160, China.

A new species, Eudorylaimus piceae n. sp., extracted from rhizosphere soil of Picea crassifolia from Inner Mongolia, China was identified. Read More

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https://biotaxa.org/Zootaxa/article/view/zootaxa.4526.4.9
Publisher Site
http://dx.doi.org/10.11646/zootaxa.4526.4.9DOI Listing
December 2018
4 Reads

Molecular Screening of VAX1 Gene Polymorphisms Uncovered the Genetic Heterogeneity of Nonsyndromic Orofacial Cleft Among Saudi Arabian Patients.

Genet Test Mol Biomarkers 2019 Jan;23(1):45-50

16 WHO Collaborating Centre, University of Dundee Dental School, Dundee, Scotland.

Objective: Nonsyndromic orofacial cleft (NSOFC) including cleft lip with or without cleft palate (CL±P) and cleft palate (CP) are multifactorial developmental disorders with both genetic and environmental etiological factors. In this study we investigated the association between CL±P and CP, and two polymorphisms previously determined using genome-wide association studies, as well as the association between consanguinity and CL±P and CP.

Methods: DNA was extracted from saliva specimens from 171 triads consisting of affected individuals and their parents, as well as 189 control triads (matched for age, gender, and location) that were recruited from 11 referral hospitals in Saudi Arabia. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0207DOI Listing
January 2019
3 Reads

Epidemiological Aspects in Lip Tumors in Oltenia Region of Romania During 2012-2016.

Curr Health Sci J 2018 Jan-Mar;44(1):39-47. Epub 2018 Mar 21.

Oral Health Department, University of Medicine and Pharmacy of Craiova, Romania.

Purpose: The objective of this study was to review lip tumor diagnosed subjects from Oltenia region, in the past 5 years according to gender, age, home environment, profession, geographic area, smoking habit, associated diseases, tumor location, macroscopic aspect and histological type.

Material And Methods: The study was done at the Oral and Maxillo-Facial Clinic of the Emergency Clinical County Hospital of Craiova, and involved the analysis of patient file records, surgical registers, histopathological bulletins, from 2012-2016.

Results: Of the 175 subjects included in this study, all of them diagnosed with lip tumor pathology, 109 (62. Read More

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http://dx.doi.org/10.12865/CHSJ.44.01.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295190PMC
March 2018
1 Read

Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
Publisher Site
http://dx.doi.org/10.1186/s13223-018-0316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320604PMC
January 2019
9 Reads