7,598 results match your criteria Biopolymers[Journal]


High-efficient and synergetic antibacterial nanocomposite hydrogel with quaternized chitosan/Ag nanoparticles prepared by one-pot UV photochemical synthesis.

Biopolymers 2020 May 25:e23354. Epub 2020 May 25.

Research Institute of Materials Science, South China University of Technology, Guangzhou, China.

Hydrogel dressings have significant advantages such as absorption of tissue exudate, maintenance of proper moist environment, and promotion of cell proliferation. However, facile preparation method and high-efficient antibacterial hydrogel dressings are still a great challenge. In this study, a facile approach to prepare antibacterial nanocomposite hydrogel dressing to accelerate healing was explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23354DOI Listing

Hydrogen sulfide concentration in the milieu of the hydrated alanine dipeptide determines its polyproline II-beta propensity: Main chain contribution to the energetic origin of the formation of amyloid.

Biopolymers 2020 May 7:e23356. Epub 2020 May 7.

LSA Biophysics, University of Michigan, Ann Arbor, MI, U.S.A.

In view of the observation that the concentration of hydrogen sulfide in brains with Alzheimer's disease (AD) is lower than that in normal brains and in line with our previous studies indicating that additional content in the aqueous environment (milieu) of a peptide can change its local energetic preference from a polyproline II (P) to a β conformation (and therefore its tendency to form the β-chain structures that lead to the amyloid plaques associated with the disease), we have studied the effect of H S concentration on such propensity in a simple model peptide, the alanine dipeptide (ADP). The two concentration states are represented by ADP(H O) (H S) and ADP(H O) (H S) . Ab initio calculations of these structures show that the lowest energy of the former is a β conformation while that of the latter is a P, mirroring the observed AD results and strengthening our proposal that amyloid diseases are better viewed in the context of a protein milieu-folding paradigm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23356DOI Listing

Simulation of the conformational flexibility of the mycodextran under external forces.

Biopolymers 2020 May 5:e23357. Epub 2020 May 5.

Department of Theoretical Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Lublin, Poland.

Mycodextran-also known as nigeran-is an unbranched polysaccharide made of α-d-glucopyranose units alternatively connected by (1 → 3) and (1 → 4) glycosidic linkages produced intracellularly by Aspergillus niger and Penicillium crustosum. In this work we examine possible enforced conformational transitions in the glucopyranose rings in the nigeran oligosaccharide chains. In order to simulate such structural changes we used the Enforced Geometry Optimization (EGO) method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23357DOI Listing

Injectable and moldable hydrogels for use in sensitive and wide range strain sensing applications.

Biopolymers 2020 Apr 30:e23355. Epub 2020 Apr 30.

Department of Chemistry, Drexel University, Philadelphia, Pennsylvania, USA.

Recently, the use of hybrid double network (DN) hydrogels has become prominent due to their enhanced mechanical properties, which has opened the door for new applications of these soft materials. Only a few of these gels have demonstrated both injectable and moldable capabilities. In this work, we report the mechanical properties, gauge factor (GF) values and demonstrate both the injectability and moldability of a gelatin/polyacrylamide DN hydrogel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23355DOI Listing

Combining particle tracking microrheology and viscometry for the study of DNA aqueous solutions.

Biopolymers 2020 Mar 30:e23353. Epub 2020 Mar 30.

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, Greece.

We use video particle tracking microrheology (VPTMR) in order to investigate the viscoelasticity of salmon DNA and correlate it to its steady-flow shear-thinning viscosity. Aqueous solutions of DNA are tested in a wide concentration range from the dilute to the semidilute unentangled concentration regime. The observed mean squared displacement shows power-law scaling with lag-time which is equivalent to power-law behavior of the complex modulus as a function of frequency that is, |G (ω)| = S ∙ ω . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23353DOI Listing

Formation of α-synuclein aggregates in aqueous ethylammonium nitrate solutions.

Biopolymers 2020 Mar 23:e23352. Epub 2020 Mar 23.

Department of Applied Chemistry, National Defense Academy, Yokosuka, Kanagawa, Japan.

The effect of adding ethylammonium nitrate (EAN), which is an ionic liquid (IL), on the aggregate formation of α-synuclein (α-Syn) in aqueous solution has been investigated. FTIR and Raman spectroscopy were used to investigate changes in the secondary structure of α-Syn and in the states of water molecules and EAN. The results presented here show that the addition of EAN to α-Syn causes the formation of an intermolecular β-sheet structure in the following manner: native disordered state → polyproline II (PPII)-helix → intermolecular β-sheet (α-Syn amyloid-like aggregates: α-SynA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23352DOI Listing

α-Chitin dissolution, N-deacetylation and valorization in deep eutectic solvents.

Biopolymers 2020 May 12;111(5):e23351. Epub 2020 Mar 12.

National Institute of Chemistry, Ljubljana, Slovenia.

Chitin displays a highly rigid structure due to the vast intra- and intermolecular hydrogen bonding, thus hindering its dissolution and deacetylation using most solvents. Deep eutectic solvents (DESs) are special and environmentally friendly solvents composed of a hydrogen bond acceptor and a hydrogen bond donor. This allows them to dissolve chitin by disturbing its natural hydrogen bonding while establishing new bonds, hence turning the polymer more susceptible to solvents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23351DOI Listing

The congenital cataract-causing mutations P20R and A171T are associated with important changes in the amyloidogenic feature, structure and chaperone-like activity of human αB-crystallin.

Biopolymers 2020 May 28;111(5):e23350. Epub 2020 Feb 28.

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russia.

Cataract is the major reason for human blindness worldwide. α-Crystallin, as a key chaperone of eye lenses, keeps the lenticular tissues in its transparent state over time. In this study, cataract-causing familial mutations, P20R and A171T, were introduced in CRYАB gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23350DOI Listing

Engineering repeat proteins of the immune system.

Biopolymers 2020 Apr 7;111(4):e23348. Epub 2020 Feb 7.

Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, U.S.A.

Limitations associated with immunoglobulins have motivated the search for novel binding scaffolds. Repeat proteins have emerged as one promising class of scaffolds, but often are limited to binding protein and peptide targets. An exception is the repeat proteins of the immune system, which have in recent years served as an inspiration for binding scaffolds which can bind glycans and other classes of biomolecule. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23348DOI Listing

Solubilization of poorly water-soluble bioactive molecules in neutral aqueous media by complexation with renatured β-1,3-1,6-glucan nanoparticles.

Biopolymers 2020 Apr 6;111(4):e23349. Epub 2020 Feb 6.

Department of Nanobiochemistry, Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, Japan.

The design of scaffolds for solubilizing/dispersing poorly water-soluble bioactive molecules in neutral aqueous media is a major challenge of functional food, pharmaceuticals, and cosmetics development, as highlighted by the plethora of corresponding solubilization/dispersion strategies. Herein, renatured β-1,3-1,6-glucan (r-glucan) nanoparticles prepared by neutralization of alkali-denatured β-1,3-1,6-glucan and subsequent centrifugation are used as a host to disperse water-insoluble bioactive molecules (curcumin, all-trans-retinoic acid, and rebamipide) by simple mixing of host and guest solutions. Curcumin in the r-glucan cavity is found to be stacked in the form of J-aggregates and twisted along the helix, and is demonstrated to be retained for significantly longer than curcumin in the corresponding γ-cyclodextrin (γ-CD) complex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23349DOI Listing

Bright solitary waves as charge transport in DNA: A variational approximation.

Biopolymers 2020 Mar 24;111(3):e23346. Epub 2019 Dec 24.

African Centre for Advanced Studies, Yaounde, Cameroon.

Modeling energy and charge transfer in DNA has been a challenging issue because of many conformations DNA can take. Due to its simplicity, we propose a discrete variational approach to study the charge transfer mechanism in DNA based on the Holstein-Su-Schrieffer-Heeger model. It is shown that bright solitary waves may propagate through the DNA and the variational approximation provides explicit relations between experimental parameters and important characteristics of the waves such as amplitude, width, chirp and homogenous phase, and energy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23346DOI Listing

Quantification of morphochemical changes during in situ enzymatic hydrolysis of individual biomass particles based on autofluorescence imaging.

Biopolymers 2020 Mar 23;111(3):e23347. Epub 2019 Dec 23.

Department of Molecular Cell Biology, CARIM, GROW, MHeNs, NUTRIM, Maastricht University, Maastricht, ER, The Netherlands.

Enzymatic hydrolysis of biomass is an established method for producing biofuels. Lignocellulosic biomass such as corn stover is very inhomogeneous material with big variation on conversion rates between individual particles therefore leading to variable recalcitrance results. In this study, we used noninvasive optical microscopy techniques, such as two-photon microscopy and fluorescence lifetime imaging microscopy, to visualize and analyze morphological and chemical changes of individual corn stover particles pretreated with sulfuric acid during hydrolysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154748PMC

Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation.

Biopolymers 2020 May 5;111(5):e23343. Epub 2019 Dec 5.

Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL, 33431, U.S.A.

Human calcitonin (hCT) is a 32-residue peptide that aggregates to form amyloid fibrils under appropriate conditions. In this study, we investigated the effect of the intramolecular disulfide bond formed at the N-terminal region of the peptide in the aggregation kinetics of hCT. Our results indicate that the presence of the disulfide bond in hCT plays a crucial role in forming the critical nucleus needed for fibril formation, facilitating the rate of hCT amyloidogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23343DOI Listing

Effect of the concentration of protein and nanoparticles on the structure of biohybrid nanocomposites.

Biopolymers 2020 Feb 3;111(2):e23342. Epub 2019 Dec 3.

Institute of Experimental Physics, Slovak Academy of Sciences, Košice, Slovakia.

We present colloidal nanocomposites formed by incorporating magnetite Fe O nanoparticles (MNPs) with lysozyme amyloid fibrils (LAFs). Preparation of two types of solutions, with and without addition of salt, was carried out to elucidate the structure of MNPs-incorporated fibrillary nanocomposites and to study the effect of the presence of salt on the stability of the nanocomposites. The structural morphology of the LAFs and their interaction with MNPs were analyzed by atomic force microscopy and small-angle x-ray scattering measurements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23342DOI Listing
February 2020

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting.

Biopolymers 2020 Jan 14;111(1):e23336. Epub 2019 Nov 14.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

The pharmacological therapy for gastrointestinal (GI) diseases, such as inflammatory bowel diseases, continues to present challenges in targeting efficacy. The need for maximal local drug exposure at the inflamed regions of the GI tract has led research to focus on a disease-targeted drug delivery approach. Smart nanomaterials responsive to the reactive oxygen species (ROS) concentrated in the inflamed areas, can be formulated into nanoplatforms to selectively release the active compounds, avoiding unspecific drug delivery to healthy tissues and limiting systemic absorption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23336DOI Listing
January 2020
2.385 Impact Factor

Assessment of biological activities of chitosan Schiff base tagged with medicinal plants.

Biopolymers 2020 Mar 7;111(3):e23338. Epub 2019 Nov 7.

Department of Chemistry, COMSAT University, Islamabad, Abbottabad Campus-22060, KPK, Pakistan.

A chitosan Schiff base with an aromatic aldehyde was synthesized and characterized by FTIR and NMR spectroscopies. Furthermore, the degree of substitution was calculated based on the ratios of the area of the proton of the imine (A ) and the area of the peak of the proton of the pyranose ring (A ). The antimicrobial activities were determined against bacterial and fungal strains, as well as multiple drug-resistant (MDR) bacteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23338DOI Listing

Combination mode of antimalarial drug mefloquine and human serum albumin: Insights from spectroscopic and docking approaches.

Biopolymers 2020 Feb 6;111(2):e23337. Epub 2019 Nov 6.

Faculty of Science, Biochemistry Programme, Biomolecular Research Group, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.

The interaction between mefloquine (MEF), the antimalarial drug, and human serum albumin (HSA), the main carrier protein in blood circulation, was explored using fluorescence, absorption, and circular dichroism spectroscopic techniques. Quenching of HSA fluorescence with MEF was characterized as static quenching and thus confirmed the complex formation between MEF and HSA. Association constant values for MEF-HSA interaction were found to fall within the range of 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23337DOI Listing
February 2020
2.385 Impact Factor

Unfolding of CBP21, a lytic polysaccharide monooxygenase, without dissociation of its copper ion cofactor.

Biopolymers 2020 Jan 5;111(1):e23339. Epub 2019 Nov 5.

Graduate School of Science and Technology, Niigata University, Niigata, Japan.

Chitin-binding protein 21 (CBP21) from Serratia marcescens is a lytic polysaccharide monooxygenase that contains a copper ion as a cofactor. We aimed to elucidate the unfolding mechanism of CBP21 and the effects of Cu on its structural stability at pH 5.0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23339DOI Listing
January 2020
2.385 Impact Factor

Molecular mechanism of the association and dissociation of Deltarasin from the heterodimeric KRas4B-PDEδ complex.

Biopolymers 2019 Nov 30;110(11):e23333. Epub 2019 Sep 30.

Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México City, Mexico.

The formation of the KRas4B-PDEδ complex activates different signaling pathways required for the development and maintenance of cancer. Previous experimental and theoretical studies have allowed researchers to design an inhibitor of the KRas4B-PDEδ complex, "Deltarasin." This inhibitor binds to the prenyl-binding pocket of PDEδ and subsequently inhibits the proliferation of human pancreatic ductal adenocarcinoma cells that depend on oncogenic KRas4B. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23333DOI Listing
November 2019
1 Read

Self-assembly in amphiphilic macromolecules with solvent exposed hydrophobic moieties.

Biopolymers 2019 Dec 9;110(12):e23330. Epub 2019 Sep 9.

Department of Chemical, Biological and Macro-Molecular Sciences, S. N. Bose National Centre for Basic Sciences, Sector III, Block JD, Salt Lake, Kolkata, India.

Self-assembly by amphiphilic molecules with solvent exposed hydrophobic groups are relevant in biomolecular systems as well as in technological applications. Here we study such self-assembly in these systems using a model system of spherical particles having charge at core but solvent repelling surface, using Monte-Carlo simulations and mean field treatment. We find that solvophobicity mediated attraction leads aggregation, while electrostatic repulsions control stability of finite clusters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23330DOI Listing
December 2019

Optimizing the fold stability of the circularly permuted Trp-cage motif.

Biopolymers 2019 Dec 3;110(12):e23327. Epub 2019 Sep 3.

Department of Chemistry, University of Washington, Seattle, Washington, United States of America.

Through optimization of the linker region and key stabilizing mutations, it has been possible to improve the stability of the circularly permuted (cp) Trp-cage miniprotein. However, even the most stable Trp-cage circular permutants are still less stable than the analogous standard topology (std) Trp-cages. Extending mutational studies of Trp-cage fold stability to cp-species, including analogs lacking chain terminal charges, has uncovered and quantitated some additional stabilizing and destabilizing interactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23327DOI Listing
December 2019

Comprehensive structural modeling and preparation of human 5-HT G-protein coupled receptor in functionally active form.

Biopolymers 2020 Jan 30;111(1):e23329. Epub 2019 Aug 30.

Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.

The serotonin 2A receptor (5-HT R) is an important member of the G-protein coupled receptor (GPCR) family involved in an array of neuromodulatory functions. Although the high-resolution structures of truncated versions of GPCRs, captured in ligand-bound conformational states, are available, the structures lack several functional regions, which have crucial roles in receptor response. Here, in order to understand the structure and dynamics of the ligand-free form of the receptor, we have performed meticulous modeling of the 5-HT R with the third intracellular loop (ICL3). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23329DOI Listing
January 2020
1 Read

Bioactive glass functionalized chondroitin sulfate hydrogel with proangiogenic properties.

Biopolymers 2019 Dec 27;110(12):e23328. Epub 2019 Aug 27.

Department of Applied Chemistry, Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.

Blood vessels play an important role in bone defect repair and growth, and a critical challenge of bone defect repair is the promotion of blood vessel formation. Most of the current methods promote vascularization by adding specific growth factors, which are costly and easy to inactivate. In this study, we developed a covalently cross-linked aminated bioactive glass nanoparticle-chondroitin sulfate methacrylate (ABGN-CSMA) organic-inorganic composite hydrogel with angiogenic properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23328DOI Listing
December 2019

Molecular folding science.

Biopolymers 2019 06;110(6):e23314

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, U.S.A.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/bip.23314
Publisher Site
http://dx.doi.org/10.1002/bip.23314DOI Listing
June 2019
2 Reads

Cellular architecture and migration behavior of fibroblast cells on polyhydroxyoctanoate (PHO): A natural polymer of bacterial origin.

Biopolymers 2019 Nov 26;110(11):e23324. Epub 2019 Jul 26.

Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Krakow, Poland.

Biodegradable and biocompatible novel materials of natural origin are gaining more and more attention in recent years. These so called biopolymers, characterized by their biointegrity and biocompatibility, find completely new and promising applications in biomedical sciences. The presented work focuses on the medium chain length elastomeric polyhydroxyalkanoate biopolymer-polyhydroxyoctanoate (PHO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23324DOI Listing
November 2019
2 Reads

Sequence characteristics responsible for protein-protein interactions in the intrinsically disordered regions of caseins, amelogenins, and small heat-shock proteins.

Biopolymers 2019 Sep 8;110(9):e23319. Epub 2019 Jul 8.

Research School of Chemistry, The Australian National University, Acton, Australian Capital Territory, Australia.

Milk caseins and dental amelogenins are intrinsically disordered proteins (IDPs) that associate with themselves and others. Paradoxically, they are also described as hydrophobic proteins, which is difficult to reconcile with a solvent-exposed conformation. We attempt to resolve this paradox. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23319DOI Listing
September 2019
1 Read

Dual stimuli-responsive polypeptide prepared by thiol-ene click reaction of poly(l-cysteine) and N, N-dimethylaminoethyl acrylate.

Biopolymers 2019 Sep 5;110(9):e23318. Epub 2019 Jul 5.

Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.

Stimuli-responsive polymers that can undergo conformational changes with external triggers have enabled themselves as smart materials for various utilizations, among which biodegradability is of particular importance to be engineered for biomedical application. In this study, a thermo and pH dual responsive polypeptide (N, N-dimethylaminoethyl acrylate-modified poly(l-cysteine)) (PLC-g-DMAEA) was prepared by the combination of N-carboxyanhydride ring-open polymerization and thiol-ene click chemistry. The biodegradable poly(l-cysteine) (PLC) with pendant thiol groups provided an easily clickable backbone for postmodification, which was demonstrated by reacting with a well-known monomer of N, N-dimethylaminoethyl acrylate (DMAEA) to achieve both temperature and pH responsiveness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23318DOI Listing
September 2019
2.385 Impact Factor

A procedure combining molecular docking and semiempirical method PM7 for identification of selective Shp2 inhibitors.

Biopolymers 2019 Nov 3;110(11):e23320. Epub 2019 Jul 3.

Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil.

Shp2 and Shp1 make up a small family of protein tyrosine phosphatases. Finding selective inhibitors for Shp2 is useful because although its inhibition is advantageous for the treatment of some types of cancer, inhibition of Shp1 may have the opposite effect, since it acts as a suppressor of tumors. We combined molecular docking and semiempirical molecular orbital-based calculations to produce data that were effective for the identification of selective inhibitors for Shp2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23320DOI Listing
November 2019
1 Read

Tuning the mechanical and physicochemical properties of cross-linked protein films.

Biopolymers 2019 Oct 1;110(10):e23321. Epub 2019 Jul 1.

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.

Films derived from natural sources such as proteins provide an advantage over synthetic films due to their noncytotoxicity, biodegradability, and vast functionality. A new protein source gained from the cataractous eye protein isolate (CEPI) obtained after surgery has been investigated for this purpose. Glycerol has been employed as the plasticizer and glutaraldehyde (GD) as a cross-linker. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23321DOI Listing
October 2019
2 Reads

Conformation and cooperative order-disorder transition in aqueous solutions of β-1,3-d-glucan with different degree of branching varied by the Smith degradation.

Biopolymers 2019 Sep 10;110(9):e23315. Epub 2019 Jun 10.

Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.

β-1,3-d-glucan with different degrees of branching were obtained by selectively and gradually removing side chains from schizophyllan, a water-soluble triple helical polysaccharide, using the Smith degradation. Size exclusion chromatography combined with a multi-angle light scattering detection was performed in aqueous 0.1 M NaCl. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23315DOI Listing
September 2019

Oligomers of α-ABpeptoid/β -peptide hybrid.

Biopolymers 2019 Jun 31;110(6):e23289. Epub 2019 May 31.

Department of Chemistry and Division of Advanced Material Science, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.

Peptoids, oligomers of N-substituted glycines, have been attracting increasing interest due to their advantageous properties as peptidomimetics. However, due to the lack of chiral centers and amide hydrogen atoms, peptoids, in general, do not form folding structures except that they have α-chiral side chains. We have recently developed "peptoids with backbone chirality" as a new class of peptoid foldamers called α-ABpeptoids and demonstrated that they could have folding conformations owing to the methyl groups on chiral α-carbons in the backbone structure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23289DOI Listing
June 2019
6 Reads

Polypeptoids synthesis based on Ugi reaction: Advances and perspectives.

Biopolymers 2019 Jun 15;110(6):e23288. Epub 2019 May 15.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

Polypeptoids are peptidomimetic polymers invented in the early 1990s. Although polypeptoid chemistry is developing rapidly, the simple synthesis of polypeptoids and sequence-controlled polypeptoids still remains a challenge. Fortunately, we have seen a drastic rising trend in the area of Ugi reaction for polypeptoid chemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23288DOI Listing
June 2019
3 Reads
2.385 Impact Factor

Peptoids as tools and sensors.

Authors:
Adrian S Culf

Biopolymers 2019 Jun 9;110(6):e23285. Epub 2019 May 9.

Sussex Research Laboratories, Inc., Ottawa, Ontario, Canada.

A review of molecular tools and sensors assembled on N-substituted glycine, or α-peptoid, oligomers between 2013 and November 2018 with the following sections: (a) Peptoids as crystal growth modifiers, (b) Peptoids as catalysts, (c) Ion and molecule sequestration and transport, (d) Peptoid sensors, (e) Macromolecule recognition, (f) Cellular transporters, (g) Medical imaging, (h) Future direction and (i) Summary and outlook. Peptoids are a promising class of peptide mimic making them an excellent platform for functional molecule preparation. Attributes of peptoid oligomers include: (a) the ease of precise sequence definition and mono-dispersity; (b) access to a vast chemical space within simple and repeating chemical preparative steps and (c) thermal, chemical and biological stability all lending support for their application in a number of areas, with some that have been realised to date. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23285DOI Listing
June 2019
1 Read

Quantitative characterization of the concentration-dependent interaction between molecules of Dextran 70 in aqueous solution: Measurement and analysis in the context of thermodynamic and compressible sphere models.

Biopolymers 2019 Oct 6;110(10):e23284. Epub 2019 May 6.

Laboratory of Biochemistry & Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Public Health Service, Bethesda, Maryland.

The static light scattering and sedimentation equilibrium of solutions of Dextran 70 were measured as functions of concentration up to 100 g/L in pH 7.4 phosphate-buffered saline at temperatures between 5 and 37 °C. The concentration dependence of scattering intensity and the apparent molar mass obtained from sedimentation equilibrium were found to be nearly independent of temperature over this range to within the uncertainty of measurement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815238PMC
October 2019
2 Reads

Peptoids in Wonderland.

Biopolymers 2019 Apr;110(4):e23279

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23279DOI Listing
April 2019
1 Read

Peptoid microsphere coatings: The effects of helicity, temperature, pH, and ionic strength.

Biopolymers 2019 Jun 22;110(6):e23283. Epub 2019 Apr 22.

Ralph E. Martin Department of Chemical Engineering, University of Arkansas Fayetteville, Fayetteville, Arkansas.

Peptoids are peptidomimetic oligomers that predominantly harness similarities to peptides for biomimetic functionality. They have potential for use in biomedical applications and biosensors due to resistance to proteolytic degradation and low immunogenicity. The incorporation of chiral, aromatic side chains in the peptoid sequence allows for the formation of distinct secondary structures and self-assembly into supramolecular assemblies, including microspheres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23283DOI Listing
June 2019
2 Reads

A novel numerical model for protein sequences analysis based on spherical coordinates and multiple physicochemical properties of amino acids.

Biopolymers 2019 Aug 12;110(8):e23282. Epub 2019 Apr 12.

Department of Biomedical Engineering, College of Engineering, and Centre for Quantitative Biology, Peking University, Beijing, China.

How to characterize short protein sequences to make an effective connection to their functions is an unsolved problem. Here we propose to map the physicochemical properties of each amino acid onto unit spheres so that each protein sequence can be represented quantitatively. We demonstrate the usefulness of this representation by applying it to the prediction of cell penetrating peptides. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23282DOI Listing
August 2019
2 Reads

Helical side chain chemistry of a peptoid-based SP-C analogue: Balancing structural rigidity and biomimicry.

Biopolymers 2019 Jun 10;110(6):e23277. Epub 2019 Apr 10.

Department of Bioengineering, Stanford University, Stanford, California.

Surfactant protein C (SP-C) is an important constituent of lung surfactant (LS) and, along with SP-B, is included in exogenous surfactant replacement therapies for treating respiratory distress syndrome (RDS). SP-C's biophysical activity depends upon the presence of a rigid C-terminal helix, of which the secondary structure is more crucial to functionality than precise side-chain chemistry. SP-C is highly sequence-conserved, suggesting that the β-branched, aliphatic side chains of the helix are also important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661009PMC
June 2019
2 Reads

Collagen type I and hyaluronic acid based hybrid scaffolds for heart valve tissue engineering.

Biopolymers 2019 Aug 8;110(8):e23278. Epub 2019 Apr 8.

Department of Materials, University of Oxford, Oxford, UK.

Tissue engineers have achieved limited success so far in designing an ideal scaffold for aortic valve; scaffolds lack in mechanical compatibility, appropriate degradation rate, and microstructural similarity. This paper, therefore, has demonstrated a carbodiimide-based sequential crosslinking technique to prepare aortic valve extracellular matrix mimicking (ECM) hybrid scaffolds from collagen type I and hyaluronic acid (HA), the building blocks of heart valve ECM, with tailorable crosslinking densities. Swelling studies revealed that crosslinking densities of parent networks increased with increasing the concentration of the crosslinking agents whereas crosslinking densities of hybrid scaffolds averaged from those of parent collagen and HA networks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23278DOI Listing
August 2019
3 Reads

Antibacterial mechanisms of GN-2 derived peptides and peptoids against Escherichia coli.

Biopolymers 2019 Jun 5;110(6):e23275. Epub 2019 Apr 5.

Department of Science and Environment, Roskilde University, Roskilde, Denmark.

Escherichia coli is the main etiological agent of urinary trait infections, able to form biofilms in indwelling devices, resulting in chronic infections which are refractory to antibiotics treatment. In this study, we investigated the antimicrobial and anti-biofilm properties exerted against E. coli ATCC 25922, by a set of peptoids and peptides modeled upon the peptide GN-2, previously reported as a valid antimicrobial agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23275DOI Listing
June 2019
4 Reads

Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5.

Biopolymers 2019 Jun 2;110(6):e23276. Epub 2019 Apr 2.

Department of Chemistry, Middle Tennessee State University, Murfreesboro, Tennessee.

Cryptococcus neoformans is a fungal pathogen that causes cryptococcal meningitis in immunocompromised individuals. Existing antifungal treatment plans have high mammalian toxicity and increasing drug resistance, demonstrating the dire need for new, nontoxic therapeutics. Antimicrobial peptoids are one alternative to combat this issue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660985PMC
June 2019
4 Reads

PEGylated PAMAM dendrimers loading oxaliplatin with prolonged release and high payload without burst effect.

Biopolymers 2019 Jul 21;110(7):e23272. Epub 2019 Mar 21.

Biomaterials and Nanotechnology Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Oxaliplatin (OXA) was coupled to PEGylated polyamidoamine dendrimers of fourth generation (G4-PEG@OXA) in the comparison to PEGylated ones of odd generation (G3.5-PEG@OXA). Proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy were used to confirm the successful incorporation of OXA as well as the synthesis of carrier systems. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/bip.23272
Publisher Site
http://dx.doi.org/10.1002/bip.23272DOI Listing
July 2019
6 Reads

NCα-gem-dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics.

Biopolymers 2019 Jun 21;110(6):e23273. Epub 2019 Mar 21.

Université Clermont Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, France.

The design of linear peptoid oligomers adopting well-defined secondary structures while mimicking defined peptide primary sequences is a major challenge in the context of drug discovery. To this end, chemists have developed cis-inducing peptoid side chains to build robust polyproline type I helices. However, the number of efficient examples remains scarce and chemical diversity accessible through the use of these side chains is limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23273DOI Listing
June 2019
1 Read

Peptoid drug discovery and optimization via surface X-ray scattering.

Biopolymers 2019 Jun 20;110(6):e23274. Epub 2019 Mar 20.

Center for the Molecular Study of Condensed Soft Matter and Department of Physics, Illinois Institute of Technology, Chicago, Illinois.

Synthetic polymers mimicking antimicrobial peptides have drawn considerable interest as potential therapeutics. N-substituted glycines, or peptoids, are recognized by their in vivo stability and ease of synthesis. Peptoids are thought to act primarily on the negatively charged lipids that are abundant in bacterial cell membranes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661014PMC
June 2019
1 Read

Local and long range potentials for heparin-protein systems for coarse-grained simulations.

Biopolymers 2019 Aug 13;110(8):e23269. Epub 2019 Mar 13.

Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.

Heparin belongs to glycosaminoglycans (GAGs), a class of periodic linear anionic polysaccharides, which are functionally important components of the extracellular matrix owing to their interactions with various protein targets. Heparin is known to be involved in many cell signaling processes, while the experimental data available for heparin are significantly more abundant than for other GAGs. At the same time, the length and conformational flexibility of the heparin represent major challenges for its theoretical analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23269DOI Listing
August 2019
1 Read

Phosphoramitoids-A submonomer approach to sequence defined N-substituted phosphoramidate polymers.

Biopolymers 2019 Apr 13;110(4):e23268. Epub 2019 Mar 13.

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California.

There is a growing interest in new methods to generate bio-inspired, chemically diverse, sequence-defined synthetic polymers. Solid-phase submonomer approaches offer facile access to these types of materials, since they take advantage of readily available synthons. Submonomer approaches to date have been applied to peptidomimetics with oligo-amide backbones. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/bip.23268
Publisher Site
http://dx.doi.org/10.1002/bip.23268DOI Listing
April 2019
71 Reads

Stereochemistry of polypeptoid chain configurations.

Biopolymers 2019 Jun 5;110(6):e23266. Epub 2019 Mar 5.

Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California.

Like polypeptides, peptoids, or N-substituted glycine oligomers, have intrinsic conformational preferences due to their amide backbones and close spacing of side chain substituents. However, the conformations that peptoids adopt are distinct from polypeptides due to several structural differences: the peptoid backbone is composed of tertiary amide bonds that have trans and cis conformers similar in energy, they lack a backbone hydrogen bond donor, and have an N-substituent. To better understand how these differences manifest in actual peptoid structures, we analyzed 46 high quality, experimentally determined peptoid structures reported in the literature to extract their backbone conformational preferences. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/bip.23266
Publisher Site
http://dx.doi.org/10.1002/bip.23266DOI Listing
June 2019
6 Reads

Unconstrained peptoid tetramer exhibits a predominant conformation in aqueous solution.

Biopolymers 2019 Jun 5;110(6):e23267. Epub 2019 Mar 5.

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California.

Conformational control in peptoids, N-substituted glycines, is crucial for the design and synthesis of biologically-active compounds and atomically-defined nanomaterials. While there are a growing number of structural studies in solution, most have been performed with conformationally-constrained short sequences (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23267DOI Listing
June 2019
10 Reads

Design and preparation of organic nanomaterials using self-assembled peptoids.

Biopolymers 2019 Apr 23;110(4):e23265. Epub 2019 Feb 23.

School of Engineering, Center for Biomedical Engineering, Institute for Molecular and Nanoscale Innovation, Brown University, Providence, Rhode Island.

The self-assembly and self-organization of peptoids, peptidomimetic polymers composed of N-substituted glycine monomers, can result in a plethora of well-defined organic nanostructures. Such classes of nanomaterials represent highly interesting functional platforms for many applications, for example, drug delivery, sensing, and catalysis. The main advantages of using self-assembling peptoids to engineer organic nanostructures include their chemical diversity, biocompatibility, enzymatic stability, and ease of synthesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23265DOI Listing
April 2019
1 Read

Reversing the typical pH stability profile of the Trp-cage.

Biopolymers 2019 Mar 19;110(3):e23260. Epub 2019 Feb 19.

Department of Chemistry, University of Washington, Seattle, Washington.

The Trp-cage, an 18-20 residue miniprotein, has emerged as a primary test system for evaluating computational fold prediction and folding rate determination efforts. As it turns out, a number of stabilizing interactions in the Trp-cage folded state have a strong pH dependence; all prior Trp-cage mutants have been destabilized under carboxylate-protonating conditions. Notable among the pH dependent stabilizing interactions within the Trp-cage are: (1) an Asp as the helix N-cap, (2) an H-bonded Asp9/Arg16 salt bridge, (3) an interaction between the chain termini which are in close spatial proximity, and (4) additional side chain interactions with Asp9. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/bip.23260
Publisher Site
http://dx.doi.org/10.1002/bip.23260DOI Listing
March 2019
6 Reads