9,230 results match your criteria Biopharmaceutics & Drug Disposition[Journal]


Development of a fast and precise method for simultaneous quantification of the PLGA monomers lactic and glycolic acid by HPLC.

J Pharm Anal 2019 Apr 11;9(2):100-107. Epub 2019 Jan 11.

Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus C4 1, Saarland D-66123, Germany.

Poly(lactide--glycolide acid) (PLGA) is an extraordinary well-described polymer and has excellent pharmaceutical properties like high biocompatibility and good biodegradability. Hence, it is one of the most used materials for drug delivery and biomedical systems, also being present in several US Food and Drug Administration-approved carrier systems and therapeutic devices. For both applications, the quantification of the polymer is inalienable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20951779183039
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http://dx.doi.org/10.1016/j.jpha.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460425PMC
April 2019
1 Read

Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3/Nrf2 Signaling Pathway and Inhibiting the NF-B Signaling Pathway in 5/6 Nephrectomized Rats.

Oxid Med Cell Longev 2019 18;2019:2853534. Epub 2019 Mar 18.

Department of Physiology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.

Salvianolic acid A (SAA) is a bioactive polyphenol extracted from Bunge, which possesses a variety of pharmacological activities. In our previous study, we have demonstrated that SAA effectively attenuates kidney injury and inflammation in an established animal model of 5/6 nephrectomized (5/6Nx) rats. However, there has been limited research regarding the antioxidative effects of SAA on chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1155/2019/2853534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442489PMC

A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent.

Mitochondrion 2019 Apr 19. Epub 2019 Apr 19.

Department of Inborn Errors of Metabolism, FSBI 'Research Centre for Medical Genetics', Moscow, Russia.

We present a 14-year-old girl with loss of motor functions, tetraplegia, epilepsy and nystagmus, caused by a novel heteroplasmic m.641A>T transition in an evolutionary conserved region of mitochondrial genome, affecting the aminoacyl stem of mitochondrial tRNA-Phe. In silico prediction, respirometry, Western blot and enzymatic analyses in skin fibroblasts support the pathogenicity of the m. Read More

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http://dx.doi.org/10.1016/j.mito.2019.04.004DOI Listing

Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca]i and mitochondrial fission/fusion.

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. Electronic address:

This study is aimed to investigate whether Mabuterol (Mab) inhibits proliferation of airway smooth muscle cells (ASMCs) induced by platelet-derived growth factor BB (PDGF-BB) and how far it is related to mitochondrial fission/fusion and intracellular calcium if it comes into play. To explore the mechanism of Mab's antagonizing the proliferation, Mdivi-1, DRP1 inhibitor, which has an inhibitory effect on mitochondrial fission, is used to compare with Mab. Cell viability was measured by either MTT or CCK-8. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.023DOI Listing

End-of-Life Health-Care Cost of Patients With Lung Cancer: A Retrospective Study.

Health Serv Res Manag Epidemiol 2019 Jan-Dec;6:2333392819841223. Epub 2019 Apr 10.

Laboratory of Biopharmaceutics-Pharmacokinetics, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

Introduction: Lung cancer exerts a significant societal and health-care-related economic burden and chemotherapy drugs constitute a major factor of total direct cost. The aim of the present study was to assess the direct health-care cost of lung cancer in Greece by conducting a retrospective analysis on the last 6 months of life.

Methods: The present study was based on both the medical data and costs of treatment of deceased adult patients who suffered from terminal stage IIIB/IV lung cancer (non-small cell lung cancer and small cell lung cancer) during the last 6 months of their life. Read More

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http://dx.doi.org/10.1177/2333392819841223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458659PMC

First Description of Macrolide-Resistant in Adults with Community-Acquired Pneumonia in Italy.

Biomed Res Int 2019 17;2019:7168949. Epub 2019 Mar 17.

Department of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy.

Background: is a common cause of community-acquired pneumonia (CAP). This cross-sectional study aimed to determine the prevalence of macrolide-resistant strains in a convenience series of 234 adult hospitalised and nonhospitalised subjects with a diagnosis of CAP in January 2013 to April 2015 in South Italy.

Methods: Respiratory samples were subjected to real-time PCR. Read More

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http://dx.doi.org/10.1155/2019/7168949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441498PMC

Modulation of Biological Activities in Glioblastoma Mediated by Curcumin.

Nutr Cancer 2019 Apr 22:1-13. Epub 2019 Apr 22.

a Department of Clinical and Experimental Medicine , University of Foggia , Foggia , Italy.

Curcumin is an alkaloid with various pharmacologic properties; numerous investigations have suggested that in the Central Nervous System, Curcumin has anti-inflammatory, antimicrobial, antioxidant, and antitumor effects. Gliomas are the most common primary intracranial tumors in adults. The prognosis of glioblastoma is still dismal. Read More

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https://www.tandfonline.com/doi/full/10.1080/01635581.2019.1
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http://dx.doi.org/10.1080/01635581.2019.1604978DOI Listing
April 2019
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Evaluation of a biosurfactant extract obtained from corn for dermal application.

Int J Pharm 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmaceutics & Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address:

At present, there is an increasing demand to improve the sustainability of surface-active compounds in dermal formulations. Biosurfactants, which are derived from living cells, are considered to be more environmentally friendly than synthetic surfactants. Thus, the use of biosurfactants is a promising strategy for the formulation of more environmentally friendly and sustainable dermal products. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.048DOI Listing

A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2).

Amino Acids 2019 Apr 19. Epub 2019 Apr 19.

Division of Biopharmaceutics and Pharmacokinetics, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.

We synthesized a previously identified β-tubulin-derived G protein-coupled receptor kinase 2 (GKR2) peptide (GR-11-1; DEMEFTEAESNMN) and its amino-terminal extension (GR-11-1-N; GEGMDEMEFTEAESNMN) and carboxyl-terminal extension (GR-11-1-C; DEMEFTEAESNMNDLVSEYQ) peptides with the aim of finding a high-affinity peptide substrate for GRK2. GR-11-1-C showed high affinity for GRK2, but very low affinity for GKR5. Its specificity and sensitivity for GKR2 were greater than those of GR-11-1 and GR-11-1-N. Read More

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http://link.springer.com/10.1007/s00726-019-02735-0
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http://dx.doi.org/10.1007/s00726-019-02735-0DOI Listing
April 2019
7 Reads

Long-term storage of PEGylated liposomal oxaliplatin with improved stability and long circulation times in vivo.

Int J Pharm 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, 1-78-1, Sho-machi, Tokushima 770-8505, Japan. Electronic address:

Liposomal anticancer drugs have been developed with improved clinical effects and reduced side effects. We have developed a PEGylated liposomal formulation of oxaliplatin that has anticancer effects in animal models of colorectal cancer with a favorable toxicity profile. To move this formulation into clinical development, a formulation that is stable during long term storage is needed, which has similar pharmacokinetics and therapeutic activity against solid tumors to the original formulation. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.042DOI Listing

Infrared spectroscopic study of the coil-helix transition of highly concentrated gelatin formulations.

Eur J Pharm Biopharm 2019 Apr 16. Epub 2019 Apr 16.

University of Heidelberg, IPMB, Department of Pharmaceutical Technology and Biopharmaceutics, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany. Electronic address:

The aim of this study was to investigate the applicability of ATR-FTIR spectroscopy as an analytical tool to monitor the gel formation of highly concentrated gelatin formulations. Spectral changes induced by the coil-helix transition have been studied and related to the elasticity parameter G' obtained by oscillatory rheology in simultaneous measurements. A principal component analysis of the amide I band allowed the evaluation of triple helix formation kinetics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09396411183162
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http://dx.doi.org/10.1016/j.ejpb.2019.04.010DOI Listing
April 2019
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Comparative Transcriptomic Studies on a Cadmium Hyperaccumulator and Its Non-Tolerant Counterpart .

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.

Many plants growing in mining areas exhibit high levels of cadmium (Cd) tolerance and accumulation, and thus are ideal organisms for comparative studies on molecular mechanisms of Cd hyperaccumulation. However, transcriptomic studies of hyperaccumulative plants in Violaceae are rare. is an amazing Cd hyperaccumulator in metalliferous areas of China, whereas its relative is a non-tolerant accumulator that resides at non-metalliferous sites. Read More

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http://dx.doi.org/10.3390/ijms20081906DOI Listing
April 2019
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Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:49-57. Epub 2019 Apr 3.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183116
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http://dx.doi.org/10.1016/j.jchromb.2019.04.003DOI Listing
April 2019
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Transcriptional Regulation Factors of the Human Mitochondrial Aspartate/Glutamate Carrier Gene, Isoform 2 (): USF1 as Basal Factor and FOXA2 as Activator in Liver Cells.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Department of Science, University of Basilicata, 85100 Potenza, Italy.

Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell functions. For this reason, mitochondrial carrier gene expression needs tight regulation. The human gene, encoding for the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), catalyses the electrogenic exchange of aspartate for glutamate plus a proton, thus taking part in many metabolic processes including the malate-aspartate shuttle. Read More

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http://dx.doi.org/10.3390/ijms20081888DOI Listing
April 2019
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A toll-like receptor 9 agonist sensitizes mice to mitochondrial dysfunction-induced hepatic apoptosis via the Fas/FasL pathway.

Arch Toxicol 2019 Apr 16. Epub 2019 Apr 16.

Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.

Early hepatocyte death occurs in most liver injury cases and triggers liver inflammation, which in combination with other risk factors leads to the development of liver disease. However, the pathogenesis of early phase hepatocyte death remains poorly understood. Here, C57BL/6J mice were treated with the hepatotoxic drug flucloxacillin (FLUX) and the toll-like receptor 9 agonist CpG oligodeoxynucleotide (ODN) to reproduce the early phase of drug-induced hepatotoxicity and investigate its pathogenesis. Read More

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http://dx.doi.org/10.1007/s00204-019-02454-1DOI Listing

Pulmonary delivery of siRNA as a novel treatment for lung diseases.

Ther Deliv 2019 Apr;10(4):203-206

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians University, Butenandtstraße 5-13, 81337 Munich, Germany.

Graphical abstract. Read More

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http://dx.doi.org/10.4155/tde-2019-0009DOI Listing

Nose-to-brain delivery of biologics.

Ther Deliv 2019 Apr;10(4):207-210

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University, Butenandtstraße 5-13, 81337, Munich, Germany.

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https://www.future-science.com/doi/10.4155/tde-2019-0013
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http://dx.doi.org/10.4155/tde-2019-0013DOI Listing
April 2019
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An In Vitro Study on Mitochondrial Compensatory Response Induced by Gliadin Peptides in Caco-2 Cells.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

Laboratory of Nutritional Pathophysiology, National Institute of Gastroenterology "S. de Bellis", Research Hospital, 70013 Castellana Grotte (Bari), Italy.

Dietary gliadin may show a broad spectrum of toxicity. The interplay between mitochondria and gliadin-induced oxidative stress has not been thoroughly examined in the intestinal epithelium. In this kinetic study, Caco-2 cells were exposed for 24 h to pepsin-trypsin-digested gliadin, alone or in combination with the antioxidant 2,6-di-tbutyl-p-cresol (BHT), and the effects on mitochondrial biogenesis and mtDNA were studied. Read More

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http://dx.doi.org/10.3390/ijms20081862DOI Listing
April 2019
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The first cloned sea cucumber FADD from Holothuria leucospilota: Molecular characterization, inducible expression and involvement of apoptosis.

Fish Shellfish Immunol 2019 Apr 13;89:548-554. Epub 2019 Apr 13.

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), Guangdong Provincial Key Laboratory of Applied Marine Biology (LAMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, PR China. Electronic address:

In this study, a sea cucumber Fas-associated death domain (FADD) named HLFADD was first cloned from Holothuria leucospilota. The full-length cDNA of HLFADD is 2137 bp in size, containing a 116-bp 5'-untranslated region (UTR), a 1334-bp 3'-UTR and a 687-bp open reading frame (ORF) encoding a protein of 228 amino acids with a deduced molecular weight of 26.42 kDa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193026
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http://dx.doi.org/10.1016/j.fsi.2019.04.030DOI Listing
April 2019
2 Reads

Amorphous solid dispersions of weak bases with pH-dependent soluble polymers to overcome limited bioavailability due to gastric pH variability - An in-vitro approach.

Int J Pharm 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, Bonn, Germany. Electronic address:

Several drugs are pH-dependent soluble weak bases with a poor solubility in the intestinal pH range. Additionally a variable gastric pH, which is a common issue in the population, potentially reduces the in-vivo performance due to reduced solubility at elevated pH. Aiming to avoid the influence of variable gastric pH on the dissolution performance, enteric polymers - hydroxypropylmethylcellulose acetate succinate (HPMCAS),hydroxypropylmethylcellulose phthalate (HP-55, HP-50) and methacrylic acid ethylacrylate copolymer (Eudragit L100-55) together with nevirapine as model drug were used for the preparation of solid dispersions by hot-melt extrusion. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193029
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http://dx.doi.org/10.1016/j.ijpharm.2019.04.034DOI Listing
April 2019
2 Reads

Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.

Eur J Pharm Sci 2019 Apr 13. Epub 2019 Apr 13.

Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, UK. Electronic address:

Oral administration is the most common route of drug delivery. The absorption of a drug from the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of the active pharmaceutical ingredient and its transport across the gut wall. The efficiency of these processes is determined by highly complex and dynamic interplay between the gastrointestinal tract, the dosage form and the API. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.04.013DOI Listing
April 2019
1 Read

Pharmaceutical Care in Children: Self-reported knowledge, attitudes and competency of final-year pharmacy students in Jordan.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e468-e475. Epub 2019 Mar 28.

Clinical Pharmacy & Practice Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK.

Objectives: Pharmacists require a baseline level of knowledge in paediatric pharmaceutical care in order to be able to adequately care for paediatric patients and counsel their families. This study aimed to explore the self-reported knowledge, attitudes and competency of final-year pharmacy students in Jordan regarding paediatric pharmaceutical care.

Methods: This study took place in Jordan between November 2016 and May 2017. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443271PMC
November 2018

Transcriptionally promiscuous "blurry" promoters in Tc1/ transposons allow transcription in distantly related genomes.

Mob DNA 2019 3;10:13. Epub 2019 Apr 3.

1Department of Biology, University of Bari "Aldo Moro", via Orabona 4, 70125 Bari, Italy.

Background: We have recently described a peculiar feature of the promoters in two -like elements, and . The AT-richness and the presence of weak core-promoter motifs make these promoters, that we have defined "blurry", able to activate transcription of a reporter gene in cellular systems as diverse as fly, human, yeast and bacteria. In order to clarify whether the blurry promoter is a specific feature of the transposon family, we have extended this study to promoters isolated from three additional DNA transposon and from two additional LTR retrotransposons. Read More

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https://mobilednajournal.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s13100-019-0155-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446368PMC
April 2019
1 Read

Self-assembled high molecular weight inulin nanoparticles: Enzymatic synthesis, physicochemical and biological properties.

Carbohydr Polym 2019 Jul 18;215:160-169. Epub 2019 Mar 18.

Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, C. P. 62250, Cuernavaca, Morelos, Mexico. Electronic address:

Inulin has interesting physicochemical and functional properties, and therefore a wide range of applications in the food and medical industries. It has gained great traction due to its ability to form nanoparticles and its possible application as nanovehicle for drug delivery. In this work, we demonstrated that the enzymatically-synthesized high molecular weight (HMW) inulin forms stable spherical nanoparticles with an average diameter of 112 ± 5 nm. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.03.060DOI Listing

Effect of amorphous nanoparticle size on bioavailability of anacetrapib in dogs.

J Pharm Sci 2019 Apr 10. Epub 2019 Apr 10.

Pharmaceutical Sciences, Merck & Co, Inc, West Point, PA, USA.

Amorphous solid dispersions (ASDs) are used as bioavailability enhancing formulations on the premise of the increased solubility of the amorphous form over its crystalline counterpart. Recent studies have shown that ASDs can, during dissolution, generate amorphous nanoparticles that were initially postulated to serve as a source of rapidly dissolving compound during absorption. Researchers have proposed that nanoparticles, including crystalline nanoparticles, may provide additional benefits to absorption such as drifting in the mucous layer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223549193022
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http://dx.doi.org/10.1016/j.xphs.2019.04.006DOI Listing
April 2019
3 Reads

A pair of new enantiomers of xanthones from the stems and leaves of .

Chin Med 2019 29;14:14. Epub 2019 Mar 29.

1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016 Liaoning People's Republic of China.

Background: The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this family plants.

Methods: The structures of new compounds and were elucidated mainly through comprehensive NMR and MS spectroscopic data, and their absolute configurations were determined by the comparison of the experimental and calculated electronic circular dichroism. Read More

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http://dx.doi.org/10.1186/s13020-019-0235-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441139PMC
March 2019
1 Read

Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer?

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Institute of Biomembranes, Bioenergetics and Molecular Biotechnology, National Research Council-CNR, Via Amendola 122/O, 70126 Bari, Italy.

Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended both inter- and intra-tumour, makes it a hard-to-win battle. Indeed, this genotypic and phenotypic variety, together with the adaptability of tumours, results in a plethora of chemoresistance acquisition mechanisms strongly affecting the effectiveness of treatments at different levels. Tripartite motif (TRIM) proteins are shown to be involved in some of these mechanisms thanks to their E3-ubiquitin ligase activity, but also to other activities they can exert in several cellular pathways. Read More

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http://dx.doi.org/10.3390/ijms20071776DOI Listing
April 2019
4 Reads

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Eur J Pharm Sci 2019 Apr 8;134:31-59. Epub 2019 Apr 8.

NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom; Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom. Electronic address:

The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of the main challenges in oral drug administration. Whereas pharmacokinetic (PK) food-drug interactions can have a variety of causes, pharmacodynamic (PD) food-drug interactions occur due to specific pharmacological interactions between a drug and particular drinks or food. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.04.003DOI Listing

AQP1-Containing Exosomes in Peritoneal Dialysis Effluent As Biomarker of Dialysis Efficiency.

Cells 2019 Apr 9;8(4). Epub 2019 Apr 9.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy.

The water channel Aquaporin 1 (AQP1) plays a fundamental role in water ultrafiltration during peritoneal dialysis (PD) and its reduced expression or function may be responsible for ultrafiltration failure (UFF). In humans, AQP1 is expressed in the endothelium of the peritoneal capillaries but its expression in mesothelial cells (MC) and its functional role in PD is still being debated. Here, we studied a cohort of 30 patients using PD in order to determine the presence of AQP1 in peritoneal biopsies, AQP1 release in the PD effluent through exosomes and the correlation of AQP1 abundance with the efficiency of peritoneal ultrafiltration. Read More

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http://dx.doi.org/10.3390/cells8040330DOI Listing
April 2019
4 Reads

Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c.

Biochem Biophys Res Commun 2019 Apr 6. Epub 2019 Apr 6.

State Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, Shaanxi, PR China. Electronic address:

MOTS-c, as a mitochondria derived peptide, exerts benefits for insulin resistance in HFD mice and against various stresses in an AMPK dependent way. Here, in the D-galactose chronic injection models, exogenous MOTS-c was given to determine its direct anti-aging effects. The body weight, insulin sensitivity and blood glucose were determined with mild differences. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.194DOI Listing
April 2019
2.297 Impact Factor

Hexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability.

Authors:
Ahmed Khames

Drug Des Devel Ther 2019 21;13:925-940. Epub 2019 Mar 21.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt,

Background: Association of long hydrocarbon chain with alginate molecule imparts surface active properties and increases chain flexibility.

Purpose: This work studied the efficacy of synthesized hexyl alginate derivative as a film-forming material with unique amphiphilic and mechanical properties for the preparation of rapidly disintegrating repaglinide oral films with higher drug release rate and improved bioavailability.

Methods: Alginate hexyl amide derivative was prepared and used in the formulation of oral films by solvent casting technique. Read More

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http://dx.doi.org/10.2147/DDDT.S196425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432887PMC
March 2019
1 Read

Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST.

Nat Protoc 2019 Apr 8. Epub 2019 Apr 8.

Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.

Here, we describe an optimized and detailed protocol for block-face serial microscopy tomography (FAST). FAST enables high-speed serial section fluorescence imaging of fixed brains at an axonal spatial resolution and subsequent image data processing. It renders brain-wide anatomical and functional analyses, including structural profiling of nuclear-stained brain at the single-cell level, cell-type-specific mapping with reporter animal brains and neuronal tracing with anterograde/retrograde labeling. Read More

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http://dx.doi.org/10.1038/s41596-019-0148-4DOI Listing

Ethylcellulose in Organic Solution or Aqueous Dispersion Form in Designing Taste-Masked Microparticles by the Spray Drying Technique with a Model Bitter Drug: Rupatadine Fumarate.

Polymers (Basel) 2019 Mar 20;11(3). Epub 2019 Mar 20.

Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland.

The taste of drugs is an important factor affecting pharmacotherapy effectiveness, and obtaining formulations with acceptable organoleptic properties is still an ongoing issue in pharmaceutical technology. One of the innovative methods of taste masking is preparation of microparticles by the spray drying technique, utilizing polymers with different physicochemical properties. Rupatadine fumarate (RUP) is one of the newest antihistamines, with an innovative and multidirectional mechanism of action, and an extremely bitter taste. Read More

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http://dx.doi.org/10.3390/polym11030522DOI Listing

Glycosylated Artificial Virus-Like Hybrid Vectors for Advanced Gene Delivery.

Polymers (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.

The major obstacle facing efficient gene therapy is the development of reliable delivery vehicles, which are both nontoxic and biocompatible and possess efficient cell-specific gene delivery. Previously, hybrid delivery vehicles comprising anionic liposomes and cationic polymers have been used successfully for gene therapy. In this study, hybrid vectors based on glycosylated artificial viral envelopes (including two novel compositions mimicking HIV and HSV envelopes) and polyethylenimine were morphologically and physiologically characterised. Read More

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http://dx.doi.org/10.3390/polym11020243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419053PMC
February 2019

Mechanistic Studies on the Absorption-Enhancing Effects of Gemini Surfactant on the Intestinal Absorption of Poorly Absorbed Hydrophilic Drugs in Rats.

Pharmaceutics 2019 Apr 7;11(4). Epub 2019 Apr 7.

Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Yamashina-Ku, Kyoto 607-8414, Japan.

Generally, the use of absorption enhancers might be the most effective approaches to ameliorate the enteric absorption of poorly absorbed substances. Among numerous absorption enhancers, we already reported that a gemini surfactant, sodium dilauramidoglutamide lysine (SLG-30) with two hydrophobic and two hydrophilic moieties, is a novel and promising adjuvant with a high potency in improving the absorption safely. Here, we examined and elucidated the absorption-improving mechanisms of SLG-30 in the enteric absorption of substances. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040170DOI Listing

Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development.

Drug Discov Today 2019 Apr 5. Epub 2019 Apr 5.

Early Pharmaceutical Development, Allergan plc, 2525 Dupont Drive, Irvine, CA, 92612, United States.

The estimation of ocular pharmacokinetics (PK) in various eye tissues is limited because of sampling challenges. Computational modeling and simulation tools underpinning the elucidation of drug access routes and prediction of ocular exposure are essential for the mechanistic assessment of biopharmaceutics in the eye. Therefore, theoretical and experimental evaluation of ocular absorption and transit models is necessary. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.04.002DOI Listing
April 2019
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Self-assembly pH-sensitive Chitosan/Alginate Coated Polyelectrolyte Complexes for Oral Delivery of Insulin.

J Microencapsul 2019 Apr 8:1-30. Epub 2019 Apr 8.

a Biomaterial Research Center, School of Pharmaceutical Sciences, Southern Medical University , 1023 Southern Shatai Street , Guangzhou , Guangdong 510515 , China.

Polyelectrolyte complexes (PEC) provide new opportunities for controlled release system of drugs, and have potentials to address challenges on the way to effective oral insulin delivery. Here, an innovative pH-sensitive PEC for insulin oral administration was developed, which was formed by self-assembly of two oppositely charged nanoparticles (chitosan-coated nanoparticles and alginate-coated nanoparticles) through electrostatic interaction via optimized double emulsion method. The encapsulation efficiency of insulin-loaded alginate-coated and chitosan-coated nanoparticles were 81. Read More

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http://dx.doi.org/10.1080/02652048.2019.1604846DOI Listing

Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging.

J Control Release 2019 Apr 3;302:140-147. Epub 2019 Apr 3.

King's College London, Institute of Pharmaceutical Science, London SE1 9NH, UK.

This study aimed to characterise three nasal drug delivery devices to evaluate their propensity to deliver human insulin solutions to the nasal cavity for redistribution to the central nervous system. Brain delivery was evaluated using functional magnetic resonance imaging to measure regional cerebral blood flow. Intranasal insulin administration has been hypothesised to exploit nose-to-brain pathways and deliver drug directly to the brain tissue whilst limiting systemic exposure. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.032DOI Listing

PCC0208027, a novel tyrosine kinase inhibitor, inhibits tumor growth of NSCLC by targeting EGFR and HER2 aberrations.

Sci Rep 2019 Apr 5;9(1):5692. Epub 2019 Apr 5.

Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, Shenyang, P.R. China.

PCC-0208027 is a novel tyrosine kinase inhibitor that has a strong inhibitory effect on epidermal growth factor receptor (EGFR)- or HER2-driven cancers. The aim is to assess the anti-tumor activity of PCC0208027 and related mechanisms in non-small cell lung cancer (NSCLC). We examined the activity of PCC0208027 on various mutated EGFRs, HER2, and HER4. Read More

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http://dx.doi.org/10.1038/s41598-019-42245-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451005PMC
April 2019
3 Reads

Self-facilitated ROS-responsive nanoassembly of heterotypic dimer for synergistic chemo-photodynamic therapy.

J Control Release 2019 Apr 1;302:79-89. Epub 2019 Apr 1.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China. Electronic address:

There is an urgent need to develop efficient combination drug delivery approaches to address the low efficiency of clinical cancer monotherapy. However, how to achieve high-efficient synchronous co-delivery and synergistic therapy remains a big challenge. Herein, we report a self-facilitated nanoassembly of a heterotypic chemo-photodynamic dimer for multimodal cancer therapy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.001DOI Listing
April 2019
7.705 Impact Factor

Antibody-Drug Conjugates- Stability and Formulation.

Eur J Pharm Biopharm 2019 Mar 30. Epub 2019 Mar 30.

Ludwig-Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 81377 Munich, Germany. Electronic address:

The number of antibody-drug conjugates (ADCs) on the market is expected to multiply in the upcoming years. The main reason: this novel drug delivery system combines the benefits of the selectivity of the antibody and the potency of the cytotoxic agent. The interplay of the antibody, linker and payload, however, calls for a stable and unique formulation. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.03.021DOI Listing

The Scalability of Wet Ball Milling for The Production of Nanosuspensions.

Pharm Nanotechnol 2019 Apr 1. Epub 2019 Apr 1.

Department of Pharmaceutics, Biopharmaceutics & NutriCosmetics, Institute of Pharmacy, Freie Universität, Berlin. Germany.

Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be performed at large scale. Ideally, the information generated at small scale is predictive for the large scale production.

Objective: This study was aimed to investigate the scalability when producing nanosuspensions starting from a 10 g scale of nanosuspension using low energy wet ball milling up to production scales of 120 g nanosuspension and 2 kg nanosuspension by using a standard high energy wet ball milling operated in batch mode or recirculation mode, respectively. Read More

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http://dx.doi.org/10.2174/2211738507666190401142530DOI Listing

Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death through Activation Which Requires in Yeast.

Oxid Med Cell Longev 2019 25;2019:4651062. Epub 2019 Feb 25.

Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Via Amendola 165/a, Bari, Italy.

Acid stress causes resistance to acetic acid-induced regulated cell death (AA-RCD) in budding yeast, resulting in catalase activation. In order to explore the molecular determinants of evasion of AA-RCD triggered by acid stress adaptation, we studied the involvement and the possible interplay of the master regulator of transcription high-osmolarity glycerol 1 () and , a positive regulator of the -dependent mitochondrial retrograde signaling. Viability, DNA fragmentation, and ROS accumulation have been analyzed in wild-type and mutant cells lacking and/or . Read More

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http://dx.doi.org/10.1155/2019/4651062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410445PMC
April 2019
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Development of Dendritic Cell-Based Immunotherapy Targeting Tumor Blood Vessels in a Mouse Model of Lung Metastasis.

Biol Pharm Bull 2019 ;42(4):645-648

Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University.

Tumor blood vessels supply cancer tissues with oxygen and nutrients, and it was therefore believed that inhibition of angiogenesis would induce tumor regression. In fact, the situation is complicated by the presence of normal blood vessels in cancer tissues such as carcinomas and sarcomas as well as abnormal vessels. Here, we describe the development of a dendritic cell (DC)-based immunotherapy which targets tumor endothelial cells (TECs) rather than normal endothelial cells (ECs) or cancer cells themselves. Read More

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http://dx.doi.org/10.1248/bpb.b18-00737DOI Listing
January 2019
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New Insight Into Thermodynamical Stability of Carbamazepine.

J Pharm Sci 2019 Mar 26. Epub 2019 Mar 26.

Department of Soft Matter Research Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.

Carbamazepine (CBZ)-an antiepileptic drug-belongs to Biopharmaceutics Classification System II Class. It has low solubility and consequently limited bioavailability. One of the ways to improve drugs solubility is amorphization of their structure. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.03.027DOI Listing

Public knowledge, attitudes and practices toward diabetes mellitus: A cross-sectional study from Jordan.

PLoS One 2019 29;14(3):e0214479. Epub 2019 Mar 29.

Faculty of Pharmacy, Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan.

Aims: To assess the knowledge and practices toward diabetes in the Jordanian community.

Methods: This study was conducted as a public based cross-sectional study in different cities in Jordan. A previously published validated questionnaire about knowledge, attitudes, and practices (KAP) toward diabetes mellitus (DM) was translated from the Arabic version and used in this study with very minor modification to be suitable for this study of the Jordanian population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214479PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440628PMC
March 2019
1 Read

Panos Macheras: a pioneering scientist in pharmaceutical science.

J Pharmacokinet Pharmacodyn 2019 Mar 28. Epub 2019 Mar 28.

School of Pharmacy and Pharmaceutical Sciences, Computational and Data Enabled Science and Engineering Program, State University of New York at Buffalo, Buffalo, NY, USA.

Professor Panos Macheras is a pioneering scientist in pharmacokinetics, pharmacodynamics and biopharmaceutics. His many important contributions to pharmaceutical science are reviewed. Read More

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http://link.springer.com/10.1007/s10928-019-09628-5
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http://dx.doi.org/10.1007/s10928-019-09628-5DOI Listing
March 2019
3 Reads

Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition.

Biomaterials 2019 Mar 21;206:1-12. Epub 2019 Mar 21.

Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address:

Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photochemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NPs), referred to as nanoplatelets. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.03.024DOI Listing
March 2019
1 Read

Curcumin loaded nanoparticles as efficient photoactive formulations against gram-positive and gram-negative bacteria.

Colloids Surf B Biointerfaces 2019 Mar 16;178:460-468. Epub 2019 Mar 16.

Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address:

The constant increase in multi-resistant bacterial strains and the decline in the number of newly approved antibiotics necessitate the development of alternative approaches to antibiotic treatment. In this study, a modern alternative approach to antibiotic therapy using photosensitiser encapsulated polymeric nanoparticles is presented. Cationic nanoparticles were prepared using a biodegradable and biocompatible polymer poly (lactic-co-glycolic acid), a stabiliser poly (vinyl alcohol) and chitosan. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.027DOI Listing

Effect of Food on the Pharmacokinetics of a Combination of Olanzapine and Samidorphan.

Clin Pharmacol Drug Dev 2019 Mar 28. Epub 2019 Mar 28.

Alkermes, Inc., Waltham, MA, USA.

ALKS 3831 is a combination of olanzapine and samidorphan (OLZ/SAM), intended to provide the antipsychotic efficacy of OLZ while mitigating its known weight gain and metabolic effects. This randomized, 2-way crossover study evaluated the effect of food on the pharmacokinetics (PK) of OLZ and SAM (both are Biopharmaceutics Classification System class 3 compounds) given in combination as OLZ/SAM. Thirty-six healthy volunteers were randomized to receive a single dose of OLZ/SAM (10 mg OLZ/10 mg SAM) in either fasted or fed conditions. Read More

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http://dx.doi.org/10.1002/cpdd.688DOI Listing