9,000 results match your criteria Biopharmaceutics & Drug Disposition[Journal]


The prevalence and clinical seriousness of medication discrepancies identified upon hospital admission of pediatric patients.

BMC Health Serv Res 2018 Dec 14;18(1):966. Epub 2018 Dec 14.

Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Al-Hodeida University, Al-Hodeida, Yemen.

Background: Medication discrepancies are seen frequently in hospital setting upon admission or discharge. Medication Reconciliation service is a practice designed to ensure that patients' medications are ordered in a correct manner upon hospital admission, thus reducing the risk of having medication discrepancies. This study aimed to determine the prevalence of medication discrepancies and their clinical seriousness in pediatric patients at the time of hospital admission. Read More

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December 2018

Reconstruction and analysis of carbon metabolic pathway of Ketogulonicigenium vulgare SPU B805 by genome and transcriptome.

Sci Rep 2018 Dec 13;8(1):17838. Epub 2018 Dec 13.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Ketogulonicigenium vulgare has been widely used in vitamin C two-step fermentation. Four K. vulgare strains (WSH-001, Y25, Hbe602 and SKV) have been completely genome-sequenced, however, less attention was paid to elucidate the reason for the differences in 2-KGA yield on genetic level. Read More

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December 2018

Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice.

J Pharmacol Sci 2018 Nov 30. Epub 2018 Nov 30.

Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address:

Kamiuntanto (KUT; Jia Wei Wen Dan Tang in Pinyin) is a traditional Japanese Kampo medicine that is used to treat psychological dysfunction. However, the mechanisms of action of KUT are not understood. To investigate the mechanisms underlying the ameliorative properties of KUT, the effects of KUT on abnormal behaviors of isolation-reared mice and on the prefrontal monoaminergic system were examined. Read More

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November 2018

The Evaluation of Concentration - In-Vitro Release Relationship for Topical Semisolid Formulations of Sodium Cromoglycate.

Authors:
A A Stănescu

Curr Health Sci J 2015 Oct-Dec;41(4):368-374. Epub 2015 Dec 22.

University of Medicine and Pharmacy "Carol Davila" Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics.

Purpose: The aim of the study was to evaluate the concentration - in-vitro release relationship for topical semisolid formulations of sodium cromoglycate. Materials / Methods. According to usual pharmaceutical compounding practice, commercially available cosmetic emulsions were used as vehicles for topical semisolid dosage forms containing 0. Read More

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December 2015

Single-Dose Pharmacokinetic Properties and Relative Bioavailability of Different Formulations of Posaconazole Oral Suspension in Healthy Volunteers.

Clin Pharmacol Drug Dev 2018 Dec 10. Epub 2018 Dec 10.

University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Zagreb, Croatia.

The rate and extent of absorption of drugs belonging to Biopharmaceutics Classification System class II are rate-limited by dissolution and highly dependent on the performance of the formulated product. The purpose of the present study was to investigate the potential impact of a surfactant and the particle size of the active substance on the in vitro drug dissolution profiles and in vivo pharmacokinetics of the poorly soluble drug posaconazole. A comparative physicochemical evaluation was conducted, and 3 formulations of posaconazole oral suspension were tested in various dissolution media compared with the reference product. Read More

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December 2018

Draft Genome Sequences of Three Novel Staphylococcus arlettae Strains Isolated from a Disused Biological Safety Cabinet.

Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.

Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, Bari, Italy.

The genome sequences of three new strains of Staphylococcus arlettae named Bari1, Bari2, and Bari3 are presented. The strains exhibited tolerance to hexavalent chromium ions. An gene encoding a putative chromium transporter was present in each of the three draft genome sequences. Read More

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October 2018

Optimization and in-vitro/in-vivo evaluation of doxorubicin-loaded chitosan-alginate nanoparticles using a melanoma mouse model.

Int J Pharm 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmaceutical Technology, University of Navarra, 31008 Pamplona, Spain. Electronic address:

The present study evaluates the potential of encapsulated doxorubicin to reduce both the viability of melanoma cells and the tumor growth in a mouse melanoma model. The prepared doxorubicin loaded chitosan/alginate nanoparticles possessed mean diameter around 300 nm and negative zeta-potential. Classical molecular dynamic simulations revealed that the high encapsulation efficiency (above 90 %) was mainly due to electrostatic interaction between doxorubicin and sodium alginate, although dipole-dipole and hydrophobic interactions might also contribute. Read More

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December 2018

Freeze/Thaw of IGG Solutions.

Eur J Pharm Biopharm 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacy-Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed at -20°C for 20hours five times (interrupted by freeze/thaw). This was done to induce excipient crystallization. Read More

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December 2018

Individualized in vitro and in silico methods for predicting in vivo performance of enteric-coated tablets containing a narrow therapeutic index drug.

Eur J Pharm Biopharm 2018 Dec 5. Epub 2018 Dec 5.

University of Greifswald, Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Center of Drug Absorption and Transport (C_DAT), Felix-Hausdorff-Straße 3, 17489 Greifswald, Germany. Electronic address:

The efficacy of narrow therapeutic index (NTI) drugs is closely related to their plasma concentration-time profile. Particularly for these compounds interindividual variability of gastrointestinal (GI) parameters relevant to in vivo drug release may result in fluctuations of the plasma concentration. The present study focused on assessing the influence of individual GI pH- and transit profiles on drug release of enteric valproate tablet formulations by means of individualized in vitro dissolution experiments. Read More

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December 2018

Nanoformulation of curcumin-loaded eudragit-nutriosomes to counteract malaria infection by a dual strategy: improving antioxidant intestinal activity and systemic efficacy.

Int J Pharm 2018 Dec 7. Epub 2018 Dec 7.

Dept. of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy.

In this paper, nutriosomes (phospholipid vesicles associated with Nutriose FM06) were modified to obtain new systems aimed at enhancing the efficacy of curcumin in counteracting malaria infection upon oral administration. Eudragit L100, a pH-sensitive co-polymer, was added to these vesicles, thus obtaining eudragit-nutriosomes, to improve their in vivo performances. Liposomes without eudragit and nutriose were also prepared as a reference. Read More

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December 2018

A critical review on 3D-printed dosage forms.

Curr Pharm Des 2018 Dec 6. Epub 2018 Dec 6.

Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf. Germany.

Background: In the last decades, 3D-printing has been investigated and used intensively in the field of tissue engineering, automotive and aerospace. With the first FDA approved printed medicinal product in 2015, the research on 3D-printing for pharmaceutical application has attracted attention of pharmaceutical scientists. Due to its potential of fabricating complex structures and geometrics, it is a highly promising technology for manufacturing individualized dosage forms. Read More

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December 2018
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A ruthenium(II) complex containing a p-cresol group induces apoptosis in human cervical carcinoma cells through endoplasmic reticulum stress and reactive oxygen species production.

J Inorg Biochem 2018 Nov 28;191:126-134. Epub 2018 Nov 28.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address:

The chemical structures of Ru (II) complexes are known to affect their cellular behavior and toxicity. In this study, three new luminescent Ru (II) complexes, [Ru(bpy)(HIPMP)](ClO) (Ru1, bpy = 2,2'-bipyridine, HIPMP = 2-(1H-imidazo-[4,5-f] [1,10] phenanthrolin-2-yl)-4-methylphenol), [Ru(phen)(HIPMP)](ClO) (Ru2, phen = 1,10-phenanthroline), [Ru(dmb)(HIPMP)](ClO) (Ru3, dmb = 4,4'-dimethyl-2,2'-bipyridine), were synthesized, and their anticancer activities were examined. All three complexes displayed anticancer activities against various cancer cells, with Ru2 exhibiting the highest cytotoxic activities. Read More

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November 2018
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Hyperhydration Induced Decrease in Urinary Luteinizing Hormone Concentrations of Male Athletes may be Compensated by Specific Gravity Adjustment in Doping Control Analysis.

Int J Sport Nutr Exerc Metab 2018 Dec 3:1-28. Epub 2018 Dec 3.

1 Anti-Doping Lab Qatar, Sports City Road, Sports City, Doha, Qatar.

Low urinary luteinizing hormone (LH) values have been discussed as a marker to detect steroid abuse. However, suppressed LH concentrations related to highly diluted urine samples could be a misleading indication of anabolic steroid abuse. One aim of the present study was to examine the effect of hyperhydration on the interpretation of LH findings during doping control analysis and to investigate different possibilities to correct volume related changes in urinary LH concentrations. Read More

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December 2018
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Novel Strategy for the Systemic Delivery of Furosemide Based on a New Drug Transport Mechanism.

Biol Pharm Bull 2018 ;41(12):1769-1777

Department of Pharmaceutical Technology, Kobe Pharmaceutical University.

We reported a novel transport mechanism of curcumin, independent of improved solubility, which involved direct contact of amorphous solid particles with the cell membrane. This mechanism has potential as a novel systemic delivery system of poorly water-soluble drugs. In this study, the transport mechanism of furosemide (FUR), which is transported by the same novel mechanism, was examined. Read More

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January 2018
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[Optimization of Nasal Drug Absorption from Powder Formulations: The Feasibility of Controlling Drug Absorption by the Use of Pharmaceutical Excipients].

Authors:
Akiko Tanaka

Yakugaku Zasshi 2018 ;138(12):1467-1472

Department of Biopharmaceutics, Kyoto Pharmaceutical University.

Nasal application of powder formulations has garnered attention because of its significant potential for systemic drug delivery. Because a powder drug must first diffuse from the formulation and dissolve in the nasal cavity fluid before transepithelial permeation, dissolution and diffusion are distinct but important factors for nasal drug absorption. Since the formulation is directly administered onto the nasal mucosal surface, the effect of excipients on drug absorption may be significant. Read More

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January 2018
2 Reads

The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity.

Authors:
Darja Kanduc

Biol Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, I-70124 Bari, Italy.

Analyses of the peptide sharing between five common human viruses (Borna disease virus, influenza A virus, measles virus, mumps virus and rubella virus) and the human proteome highlight a massive viral vs. human peptide overlap that is mathematically unexpected. Evolutionarily, the data underscore a strict relationship between viruses and the origin of eukaryotic cells. Read More

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December 2018
3 Reads

Investigation of charge ratio variation in mRNA - DEAE-dextran polyplex delivery systems.

Biomaterials 2018 Nov 17. Epub 2018 Nov 17.

Department of Pharmaceutics and Biopharmaceutics, Johannes Gutenberg University Mainz, D-55099, Mainz, Germany. Electronic address:

mRNA pharmaceuticals represent a new class of therapeutics, with applications, in cancer vaccination, tumour therapy and protein substitution. Formulations are required to deliver messenger RNA (mRNA) to the target sites where induction of genetic transfection following receptor mediated cell uptake & translation is required. In the current study, the cationic polysaccharide diethylaminoethylen (DEAE) - Dextran was selected as a model system carrier for the investigation of polyplex nanoparticle formation together with mRNA as a function of the molar ratio of the components. Read More

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November 2018

EphB2 stem-related and EphA2 progression-related miRNA-based networks in progressive stages of CRC evolution: clinical significance and potential miRNA drivers.

Mol Cancer 2018 Nov 30;17(1):169. Epub 2018 Nov 30.

Laboratory of Molecular Medicine and Biotechnology, University Campus Bio-Medico of Rome, via Alvaro del Portillo 21, 00128, Rome, Italy.

EphB2 and EphA2 control stemness and differentiation in the intestinal mucosa, but the way they cooperate with the complex mechanisms underlying tumor heterogeneity and how they affect the therapeutic outcome in colorectal cancer (CRC) patients, remain unclear. MicroRNA (miRNA) expression profiling along with pathway analysis provide comprehensive information on the dysregulation of multiple crucial pathways in CRC.Through a network-based approach founded on the characterization of progressive miRNAomes centered on EphA2/EphB2 signaling during tumor development in the AOM/DSS murine model, we found a miRNA-dependent orchestration of EphB2-specific stem-like properties in earlier phases of colorectal tumorigenesis and the EphA2-specific control of tumor progression in the latest CRC phases. Read More

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November 2018
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Evaluation of in-line particle measurement with an SFT-probe as monitoring tool for process automation using a new time-based buffer approach.

Eur J Pharm Sci 2018 Dec 3;128:162-170. Epub 2018 Dec 3.

Life Science Technologies, Ostwestfalen-Lippe University of Applied Science, Georg-Weerth-Straße 20, 32756 Detmold, Germany.

The Process Analytical Technology (PAT) initiative published by the Food and Drug administration (FDA) describes PAT systems as important tools to optimize pharmaceutical processes in order to ensure the final product quality. Real-time particle size measurements provide a promising approach for process automation of fluid bed granulation processes. This work focuses on the introduction and evaluation of a new time-based buffer approach for in-line spatial filtering technique (SFT) in order to provide a minimum time delay of the real-time measurement. Read More

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December 2018
3 Reads

l-Cysteine and l-Serine Modified Dendrimer with Multiple Reduced Thiols as a Kidney-Targeting Reactive Oxygen Species Scavenger to Prevent Renal Ischemia/Reperfusion Injury.

Pharmaceutics 2018 Dec 1;10(4). Epub 2018 Dec 1.

Department of Biopharmaceutics, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.

l-cysteine (Cys)- and l-serine (Ser)-modified, third-generation polyamidoamine (PAMAM) dendrimer with multiple reduced thiols (Ser-PAMAM-Cys) was synthesized as a kidney-targeting reactive oxygen species (ROS) scavenger to help prevent renal ischemia/reperfusion injury. Ser-PAMAM-Cys effectively scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and ROS (hydrogen peroxide and hydroxyl radical) in phosphate-buffered saline (PBS). In addition, ~64% of In-labeled Ser-PAMAM-Cys accumulated in mouse kidney 3 h after intravenous administration. Read More

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December 2018

Applications of Ruthenium Complex in Tumor Diagnosis and Therapy.

Front Pharmacol 2018 19;9:1323. Epub 2018 Nov 19.

School of Bioscience and Biopharmaceutics, Guangdong Province Key Laboratory for Biotechnology Drug Candidates, Guangdong Pharmaceutical University, Guangzhou, China.

Ruthenium complexes are a new generation of metal antitumor drugs that are currently of great interest in multidisciplinary research. In this review article, we introduce the applications of ruthenium complexes in the diagnosis and therapy of tumors. We focus on the actions of ruthenium complexes on DNA, mitochondria, and endoplasmic reticulum of cells, as well as signaling pathways that induce tumor cell apoptosis, autophagy, and inhibition of angiogenesis. Read More

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November 2018
1 Read

Clinical Development of Biologics Approved by the US Food and Drug Administration, 2003-2016.

Ther Innov Regul Sci 2018 Dec 3:2168479018812058. Epub 2018 Dec 3.

1 Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background:: Biological therapies are increasingly common in the United States. Although their clinical development may deviate significantly from the classic paradigm used for small molecule drugs, there has been little systematic analysis of these programs. We describe the development programs and factors associated with approval in the first review cycle for biologics approved by the US Food and Drug Administration's Center for Drug Evaluation and Research (FDA CDER) between 2003 and 2016. Read More

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December 2018

New Studies on Leachables in commercial scale Protein Drug Filling Lines using Stir Bar Sorptive Extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics.

Int J Pharm 2018 Nov 27. Epub 2018 Nov 27.

Ludwig Maximilian University Munich, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstr. 5, Building B, 81377 München, Germany.

The increasing application of Single-Use Systems (SUSs) in pharmaceutical manufacturing lines poses a potential risk of polymer-related impurities leaching into the process stream and persisting through the manufacturing process. To minimize any potential toxicity and impairment to the product's quality, safety thresholds are strictly regulated and enforced in particular for parenteral solutions. At present, impurities are estimated from extractable profiles, which are generated for each SUS with thermal or static extraction. Read More

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November 2018
1 Read

In silico assessment of ADME properties: Advances in Caco-2 Cell Monolayer Permeability Modeling.

Curr Top Med Chem 2018 Nov 30. Epub 2018 Nov 30.

Department of Coatings and Polymer Materials, North Dakota State University, Fargo, North Dakota, 58102. United States.

One of the main goals of in silico Caco-2 cell permeability models is to identify those drug substances with high intestinal absorption in human (HIA). For more than a decade, several in silico Caco-2 models have been made, applying a wide range of modeling techniques; nevertheless, their capacity for intestinal absorption extrapolation is still doubtful. There are three main problems related to the modest capacity of obtained models, including the existence of inter- and/or intra-laboratory variability of recollected data, the influence of the metabolism mechanism, and the inconsistent in vitro-in vivo correlation (IVIVC) of Caco-2 cell permeability. Read More

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November 2018

Future of nanomedicines for treating respiratory diseases.

Expert Opin Drug Deliv 2018 Nov 28. Epub 2018 Nov 28.

a Department of Pharmaceutics and Biopharmaceutics , Kiel University , Grasweg 9a, 24118 Kiel , Germany.

Introduction: Nanoparticles are under discussion in drug delivery for more than 20 years now, but examples for nanoparticulate formulations in the treatment of respiratory diseases are rare and mostly limited to the administration of sub-micron drug particles (ultrafine particles). However, nanoparticles may also carry specific benefits for respiratory treatment. Are nanoparticles the next-generation drug carrier system to facilitate systemic delivery, sustained release and cancer treatment in the lungs? Areas covered: This review will look into the promises and opportunities of the use of nanoparticles in the treatment of respiratory diseases. Read More

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November 2018

The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype.

Iran J Basic Med Sci 2018 Nov;21(11):1192-1197

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Crocetin, one of the main substances of saffron extract, has anti-cancer effects. Drug resistance proteins (e.g. Read More

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November 2018

Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs.

Front Behav Neurosci 2018 12;12:262. Epub 2018 Nov 12.

Department Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.

Despite a growing body of research over the last few decades, mental disorders, including anxiety disorders or depression, are still one of the most prevalent and hardest to treat health burdens worldwide. Since pharmacological treatment with a single drug is often rather ineffective, approaches such as co-medication with functionally diverse antidepressants (ADs) have been discussed and tried more recently. Besides classical ADs, there is a growing number of candidate targets identified as potential starting points for new treatment methods. Read More

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November 2018

A downstream molecule of 1,25-dihydroxyvitamin D3, alpha-1-acid glycoprotein, protects against mouse model of renal fibrosis.

Sci Rep 2018 Nov 26;8(1):17329. Epub 2018 Nov 26.

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Chuo-ku, Kumamoto, 862-0973, Japan.

Renal fibrosis, the characteristic feature of progressive chronic kidney disease, is associated with unremitting renal inflammation. Although it is reported that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, elicits an anti-renal fibrotic effect, its molecular mechanism is still unknown. In this study, renal fibrosis and inflammation observed in the kidney of unilateral ureteral obstruction (UUO) mice were reduced by the treatment of 1,25(OH)2D3. Read More

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November 2018
2 Reads

Clarithromycin Laurate Salt: Physicochemical Properties and Pharmacokinetics after Oral Administration in Humans.

Pharm Dev Technol 2018 Nov 25:1-15. Epub 2018 Nov 25.

g Al Taqaddom Pharmaceuticals , Amman , Jordan.

Clarithromycin laurate (CLM-L), a fatty acid salt of clarithromycin (CLM), was prepared by a simple co-melting process. The formation of CLM-L was confirmed using FTIR, H NMR, and C NMR. Solubility, intrinsic dissolution rate (IDR), and partitioning properties of CLM-L were determined and compared to those of CLM. Read More

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November 2018
4 Reads

Design of Experiments in metabolomics-related studies: An overview.

J Pharm Biomed Anal 2018 Nov 13;164:598-606. Epub 2018 Nov 13.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland. Electronic address:

Nowadays, Design of Experiments (DoE) approach is a very popular methodology of planning and conducting experiments, where the effect of each tested factor on the studied responses is systematically examined and documented. The results obtained in such manner represent the design space more precisely than in the case of One-Variable-At-Time (OVAT) approach, leading to reliable and comprehensive results, while saving time and resources. Despite such a large increase of interest in this approach recently, its implementation in metabolomics research seems to be limited. Read More

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November 2018

Sortagging of liposomes with a murine CD11b-specific VHH increases in vitro and in vivo targeting specificity of myeloid cells.

Eur J Pharm Biopharm 2018 Nov 20. Epub 2018 Nov 20.

BioMed X GmbH, Im Neuenheimer Feld 583, 69120 Heidelberg, Germany.

The therapeutic index of drugs can be increased via drug encapsulation in actively targeted, meaning ligand modified drug delivery systems. The manufacturing of such targeted drug delivery systems, in particular the conjugation between drug carrier and ligand, can be done by enzymatic conjugation methods, exploiting the site-specific, bioorthogonal nature of these reactions. The use of such enzymes like Sortase-A transpeptidase requires efficient purification methods, as residuals of the enzyme may be responsible for immunogenic potential and drug product instabilities. Read More

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November 2018
2 Reads

Predicting local drug availability of locally acting lozenges: From method design to a linear level A IVIVC.

Eur J Pharm Biopharm 2018 Dec 26;133:269-276. Epub 2018 Oct 26.

University of Greifswald, Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Center of Drug Absorption and Transport, 3 Felix Hausdorff Street, Greifswald 17489, Germany. Electronic address:

Lozenges are commonly applied in the treatment of sore throat. They often contain drugs intended to exert their effect locally in the oral cavity and throat. In the recent past, an increasing interest in development of generic products for locally acting lozenges could be noted. Read More

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December 2018
2 Reads

Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure.

Stem Cell Res Ther 2018 Nov 21;9(1):321. Epub 2018 Nov 21.

Institute of Translational Medicine, Nanchang University, No. 1299 Xuefu Road, Honggutan District, Nanchang, 330031, Jiangxi Province, People's Republic of China.

Background: Hepatocyte transplantation has been proposed as an effective treatment for patients with acute liver failure (ALF), but its application is limited by a severe shortage of donor livers. Human pluripotent stem cells (hPSCs) have emerged as a potential cell source for regenerative medicine. Human amniotic epithelial stem cells (hAESCs) derived from amniotic membrane have multilineage differentiation potential which makes them suitable for possible application in hepatocyte regeneration and ALF treatment. Read More

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November 2018
2 Reads
3.368 Impact Factor

Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid binder.

Int J Pharm 2018 Nov 17;555:198-206. Epub 2018 Nov 17.

Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany. Electronic address:

3D-printing is a promising tool to pave the way to the widespread adaption of individualized medicine. Several printing techniques have been investigated and introduced to pharmaceutical research. Until now, only one 3D-printed medicine is approved on the US market. Read More

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November 2018
3 Reads

Diphenyl Ethers from a Marine-Derived .

Mar Drugs 2018 Nov 16;16(11). Epub 2018 Nov 16.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Six new diphenyl ethers (⁻) along with eleven known analogs were isolated from the ethyl acetate extract of a marine-derived guided by LC-UV-MS. Their structures were unambiguously characterized by HRESIMS, NMR, as well as chemical derivatization. Compounds and are rare diphenyl ether glycosides containing d-ribose. Read More

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November 2018
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Impact of Sodium -[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics.

Molecules 2018 Nov 16;23(11). Epub 2018 Nov 16.

Department of Pharmaceutics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151 Malianwa North Road, Haidian District, Beijing 100193, China.

For drugs with high hydrophilicity and poor membrane permeability, absorption enhancers can promote membrane permeability and improve oral bioavailability. Sodium -[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) is a new kind of absorption enhancer that has good safety. To investigate the absorption enhancement effect of SNAC on non-polar charged and polar charged drugs and establish the absorption enhancement mechanism of SNAC, SNAC was synthesized and characterized. Read More

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November 2018
2 Reads

Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity.

Pharmaceutics 2018 Nov 15;10(4). Epub 2018 Nov 15.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilian University of Munich, Butenandtstr. 5-13, 81377 Munich, Germany.

β-Sitosterol (β-Sit) is a dietary phytosterol with demonstrated anticancer activity against a panel of cancers, but its poor solubility in water limits its bioavailability and therapeutic efficacy. In this study, poly(lactide-co-glycolic acid) (PLGA) and block copolymers of poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA) were used to encapsulate β-Sit into nanoparticles with the aim of enhancing its in vitro anticancer activity. β-Sitosterol-loaded PLGA and PEG-PLA nanoparticles (β-Sit-PLGA and β-Sit-PEG-PLA) were prepared by using a simple emulsion-solvent evaporation technique. Read More

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November 2018
2 Reads

Danggui Buxue Tang promotes the adhesion and migration of bone marrow stromal cells via the focal adhesion pathway in vitro.

J Ethnopharmacol 2018 Nov 14;231:90-97. Epub 2018 Nov 14.

School of Bioscience and Biopharmaceutics, Guangdong Province Key Laboratory for Biotechnology Drug Candidates, Guangdong Pharmaceutical University, 510006 Guangzhou, Guangdong, China.

Ethnopharmacology Relevance: Danggui Buxue Tang has been used in China to treat clinical anemia for more than 800 years. However, there is no scientific report on its effect on bone marrow stromal cells.

Aim Of The Study: Here, we aimed to explore the effect of Danggui Buxue Tang on bone marrow stromal cell adhesion and migration. Read More

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November 2018
3 Reads

On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing.

Eur J Pharm Biopharm 2018 Nov 12. Epub 2018 Nov 12.

Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Electronic address:

Fast and accurate manufacturing of individually tailored solid dosage forms is one of the main challenges for personalized medicine. The use of 3D printers has recently been studied to determine their suitability for personalized drug manufacturing. In the current work, formulations free of organic solvents were developed for a pressure-assisted microsyringe printing method (PAM). Read More

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November 2018
10 Reads

Inhibiting the urokinase-type plasminogen activator receptor system recovers STZ-induced diabetic nephropathy.

J Cell Mol Med 2018 Nov 13. Epub 2018 Nov 13.

Department of Biology, University of Pisa, Pisa, Italy.

The urokinase-type plasminogen activator (uPA) receptor (uPAR) participates to the mechanisms causing renal damage in response to hyperglycaemia. The main function of uPAR in podocytes (as well as soluble uPAR -(s)uPAR- from circulation) is to regulate podocyte function through αvβ3 integrin/Rac-1. We addressed the question of whether blocking the uPAR pathway with the small peptide UPARANT, which inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of streptozotocin (STZ)-induced diabetes. Read More

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November 2018
1 Read

An Effective Approach to Teaching Pharmacogenomics in the First Year of Pharmacy Curriculum.

Am J Pharm Educ 2018 Oct;82(8):6345

School of Pharmacy, West Virginia University, Morgantown, West Virginia.

To develop an effective method in teaching pharmacogenomics as a part of a new course, Biopharmaceutics and Pharmacogenomics. Teaching effectiveness was measured by quizzes, retrospective pre- and post-surveys, team activities, and journal reflections. Four team activities were included in the course: genomic disease, patient case, genetic counselor and a debate about personalized medicine. Read More

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October 2018
4 Reads

Novel Bioactive Peptides from Protect against Free Radical-Induced Oxidative Stress through the Stress Response Factor DAF-16/FOXO.

Mar Drugs 2018 Nov 11;16(11). Epub 2018 Nov 11.

Center for Bioresources and Drug Discovery, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.

The hard clam , which has been traditionally used as medicine and seafood, was used in this study to isolate antioxidant peptides. First, a peptide-rich extract was tested for its protective effect against paraquat-induced oxidative stress using the nematode model . Then, three novel antioxidant peptides; MmP4 (LSDRLEETGGASS), MmP11 (KEGCREPETEKGHR) and MmP19 (IVTNWDDMEK), were identified and were found to increase the resistance of nematodes against paraquat. Read More

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November 2018
1 Read

Use of hemoglobin for delivering exogenous carbon monoxide in medicinal applications.

Curr Med Chem 2018 Nov 13. Epub 2018 Nov 13.

Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto. Japan.

Carbon monoxide (CO), at low concentrations, can have a variety of positive effects on the body including anti-apoptosis, anti-inflammatory, anti-oxidative and anti-proliferative effects. Although CO has great potential for use as a potent medical bioactive gas, for it to exist in the body in stable form, it must be associated with a carrier. Hemoglobin (Hb) represents a promising material for use as a CO carrier because most of the total CO in the body is stored associated with Hb in red blood cells (RBC). Read More

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November 2018
6 Reads

Co-delivery of curcumin and doxorubicin in PEGylated liposomes favored the antineoplastic C26 murine colon carcinoma microenvironment.

Drug Deliv Transl Res 2018 Nov 12. Epub 2018 Nov 12.

Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", 41 Victor Babes Str., 400012, Cluj-Napoca, Romania.

Our recent studies have demonstrated that the antitumor efficacy of doxorubicin (DOX), administered in long-circulating liposomes (LCL), could be considerably improved after its co-encapsulation with curcumin (CURC). Thus, the question addressed within this article is whether LCL-CURC-DOX can be exploited more efficiently than liposomal DOX for future colorectal cancer therapy. Therefore, we investigated the physicochemical and biological properties of LCL-CURC-DOX and the mechanisms of its antitumor activity in C26 murine colon carcinoma in vivo. Read More

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November 2018
2 Reads

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.

Pharmacol Biochem Behav 2018 Nov 9;176:1-5. Epub 2018 Nov 9.

Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development (Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui), Osaka University, Suita, Osaka 565-0871, Japan; Division of Bioscience, Institute for Datability Science, Osaka University, Suita, Osaka 565-0871, Japan; Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka 565-0871, Japan. Electronic address:

Growing evidence suggests pivotal roles for epigenetic mechanisms in both animal models of and individuals with autism spectrum disorders (ASD). Neuron-restrictive silencer factor (NRSF) binds to neuron-restrictive silencing elements in neuronal genes and recruits co-repressors, such as mSin3, to epigenetically inhibit neuronal gene expression. Because dysregulation of NRSF is related to ASD, here we examined the effects of mS-11, a chemically optimized mimetic of the mSin3-binding helix in NRSF, on the behavioral and morphological abnormalities found in a mouse model of valproic acid (VPA)-induced ASD. Read More

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November 2018
4 Reads

Multi-fingerprint profiling combined with chemometric methods for investigating the quality of Astragalus polysaccharides.

Int J Biol Macromol 2018 Nov 8;123:766-774. Epub 2018 Nov 8.

The Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangzhou 510006, PR China; Guangdong Engineering & Technology Research Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, PR China. Electronic address:

It is a challenge to ascertain the quality of polysaccharides due to their complex chemical structure; therefore, multi-fingerprint profiling was used to investigate the quality of Astragalus polysaccharides (APS) harvested from Inner Mongolia (NM) and Gansu (GS) with the help of chemometric analysis. Additionally, FT-IR and H NMR were applied to characterize the chemical structure of the harvested APS. The spectral fingerprinting results indicated that APS had reduced similarity when they were from different origins. Read More

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November 2018
4 Reads

Prolonged release from orodispersible films by incorporation of diclofenac-loaded micropellets.

Int J Pharm 2018 Nov 7;554:149-160. Epub 2018 Nov 7.

Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Prolonged drug release provided by multiple-unit dosage forms is highly beneficial to enhance the compliance and safety of the pharmacotherapy even for patients with swallowing deficiencies. To facilitate the intake for these patients, multiple-unit tablets and capsules have to be crushed or opened. An attempt to overcome these issues has been made by the introduction of orodispersible films (ODFs), which rapidly disintegrate within the oral cavity and facilitate the intake of oral solid dosage forms. Read More

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November 2018
6 Reads

Riluzole prevents oxaliplatin-induced cold allodynia via inhibition of overexpression of transient receptor potential melastatin 8 in rats.

J Pharmacol Sci 2018 Nov 26;138(3):214-217. Epub 2018 Oct 26.

Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan; Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.

Oxaliplatin causes acute cold hypersensitivity in most patients. We previously reported oxalate derived from oxaliplatin induced cold allodynia via overexpression of transient receptor potential melastatin 8 (TRPM8) in the dorsal root ganglion (DRG) in rats. In this study, we examined the effect of riluzole on oxaliplatin-induced cold allodynia. Read More

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November 2018
3 Reads

Self-Dissolving Microneedle Arrays for Transdermal Absorption Enhancement of Human Parathyroid Hormone (1-34).

Pharmaceutics 2018 Nov 4;10(4). Epub 2018 Nov 4.

Department of Biopharmaceutics, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.

Human parathyroid hormone (1-34) (PTH) has been widely used as the subcutaneous injection formulation for the treatment of osteoporosis. In the present study, we developed an efficient transdermal delivery system of PTH by using dissolving microneedle arrays (MNs) composed of hyaluronic acid (HA) for the treatment of osteoporosis. PTH-loaded MNs, with needle length 800 µm, were fabricated via a micro-molding method. Read More

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November 2018
3 Reads

Integration of Precipitation Kinetics From an In Vitro, Multicompartment Transfer System and Mechanistic Oral Absorption Modeling for Pharmacokinetic Prediction of Weakly Basic Drugs.

J Pharm Sci 2018 Nov 3. Epub 2018 Nov 3.

Biopharmaceutics & Specialty Dosage Form, MRL, Merck & Co., Inc., West Point, Pennsylvania 19486.

Solubility, dissolution, and precipitation in the gastrointestinal tract can be critical for the oral bioavailability of weakly basic drugs. To understand the dissolution and precipitation during the transfer out of the stomach into the intestine, a multicompartment transfer system was developed by modifying a conventional dissolution system. This transfer system included gastric, intestinal, sink and supersaturation, and reservoir compartments. Read More

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November 2018
9 Reads