334 results match your criteria Biomolecular concepts[Journal]


Pre-operative laparoscopic staging of gastric cancer in patients who are candidates for neo-adjuvant chemotherapy: A Cross Sectional Study.

Biomol Concepts 2019 Apr 16;10(1):68-72. Epub 2019 Apr 16.

General Physician, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective The aim of this study is to evaluate the laparoscopic method in gastric cancer staging before surgery in patients undergoing Neo-adjuvant chemotherapy. Methods This was a cross-sectional study on patients with T3-T4 and node positive non-metastatic gastric adenocarcinoma who was candidates for neo-adjuvant chemotherapy. The patients were excluded from the study when they were not in the condition to continue the study. Read More

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http://dx.doi.org/10.1515/bmc-2019-0008DOI Listing

Expression of OX40 Gene and its Serum Levels in Neuromyelitis Optica Patients.

Biomol Concepts 2019 Apr 11;10(1):62-67. Epub 2019 Apr 11.

Isfahan Neuroscience Research Center, Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Neuromyelitis optica (NMO), also known as Devic's disease, is an autoimmune disorder of the central nervous system (CNS) in which immune system cells and antibodies primarily attack the optic nerves and the spinal cord. OX40 (CD134) is a tumor necrosis factor (TNF)-receptor family member expressed primarily on activated CD4+ and CD8+ T-cells. In an autoimmune disease, OX40 is typically up-regulated at sites of inflammation, and increases in the number of peripheral CD4+ T-cells expressing OX40. Read More

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http://www.degruyter.com/view/j/bmc.2019.10.issue-1/bmc-2019
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http://dx.doi.org/10.1515/bmc-2019-0007DOI Listing
April 2019
1 Read

The disordered boundary of the cell: emerging properties of membrane-bound intrinsically disordered proteins.

Biomol Concepts 2019 Apr 3;10(1):25-36. Epub 2019 Apr 3.

BioNMR Laboratory, Inorganic and Organic Chemistry Department, University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain.

We define the disordered boundary of the cell (DBC) as the system formed by membrane tethered intrinsically disordered protein regions, dynamically coupled to the underlying membrane. The emerging properties of the DBC makes it a global system of study, which cannot be understood from the individual properties of their components. Similarly, the properties of lipid bilayers cannot be understood from just the sum of the properties of individual lipid molecules. Read More

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http://dx.doi.org/10.1515/bmc-2019-0003DOI Listing

Zinc enhances the expression of morphine-induced conditioned place preference through dopaminergic and serotonergic systems.

Biomol Concepts 2019 Apr 3;10(1):51-61. Epub 2019 Apr 3.

Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran.

The antidepressant-like effects of zinc (Zn) have been documented in some animal models of depression. In addition, antidepressants may reduce the abuse potential of opioids by affecting their rewarding effect. Hence, this study was performed to investigate the effect of Zn on the expression of morphine-induced conditioned place preference (CPP) in male rats. Read More

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http://dx.doi.org/10.1515/bmc-2019-0006DOI Listing
April 2019
1 Read

Comparison of the effect of vitamin D on osteoporosis and osteoporotic patients with healthy individuals referred to the Bone Density Measurement Center.

Biomol Concepts 2019 Apr 3;10(1):44-50. Epub 2019 Apr 3.

Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran.

Objective Osteoporosis is the most common metabolic disease of the bones. Osteoporosis reduces bone density, predisposes a person to fractures, and imposes high costs on societies. Osteoporosis develops from a variety of causes, one of the most significant is vitamin D deficiency. Read More

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http://dx.doi.org/10.1515/bmc-2019-0005DOI Listing
April 2019
1 Read

ATP Synthase: Structure, Function and Inhibition.

Biomol Concepts 2019 Mar 7;10(1):1-10. Epub 2019 Mar 7.

Department of Biotechnology, Kathmandu University Dhulikhel, Nepal India.

Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria. A multi subunit structure that works like a pump functions along the proton gradient across the membranes which not only results in ATP synthesis and breakdown, but also facilitates electron transport. Read More

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http://dx.doi.org/10.1515/bmc-2019-0001DOI Listing

Antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae in Streptozotocin-induced diabetic rats.

Biomol Concepts 2019 Mar 11;10(1):37-43. Epub 2019 Mar 11.

Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.

Background It is well documented that biologically active components of microalgae can be utilized for treatment of different diseases. This study was conducted to evaluate the antihyperglycemic and antihyperlipidemic activities and weight control of Nannochloropsis oculata microalgae (NOM) in Streptozotocin-induced diabetic male rats. Methods Diabetes was induced by intraperitoneal administration of Streptozotocin (55 mg/kg). Read More

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http://dx.doi.org/10.1515/bmc-2019-0004DOI Listing

Enhancing the anticoagulant profile of meizothrombin.

Biomol Concepts 2018 Dec 26;9(1):169-175. Epub 2018 Dec 26.

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104 USA.

Meizothrombin is an active intermediate generated during the proteolytic activation of prothrombin to thrombin in the penultimate step of the coagulation cascade. Structurally, meizothrombin differs from thrombin because it retains the auxiliary Gla domain and two kringles. Functionally, meizothrombin shares with thrombin the ability to cleave procoagulant (fibrinogen), prothrombotic (PAR1) and anticoagulant (protein C) substrates, although its specificity toward fibrinogen and PAR1 is less pronounced. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0016DOI Listing
December 2018
3 Reads

Can uterine secretion of modified histones alter blastocyst implantation, embryo nutrition, and transgenerational phenotype?

Biomol Concepts 2018 Dec 26;9(1):176-183. Epub 2018 Dec 26.

Assistant Professor of Molecular Biology, Department of Biomedical Sciences, RVU, 8401 S. Chambers Road, Parker, CO 80134, USA.

Extracellular histones support rodent and human embryo development in at least two ways. First, these molecules in uterine secretions protect embryos from inflammation caused by pathogens that gain access to the reproductive tract. Also, histones in uterine secretions likely support penetration of the uterine epithelium by blastocysts during embryo implantation. Read More

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http://dx.doi.org/10.1515/bmc-2018-0017DOI Listing
December 2018

Biased receptor functionality versus biased agonism in G-protein-coupled receptors.

Biomol Concepts 2018 Dec 26;9(1):143-154. Epub 2018 Dec 26.

Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.

Functional selectivity is a property of G-protein-coupled receptors (GPCRs) by which activation by different agonists leads to different signal transduction mechanisms. This phenomenon is also known as biased agonism and has attracted the interest of drug discovery programs in both academy and industry. This relatively recent concept has raised concerns as to the validity and real translational value of the results showing bias; firstly biased agonism may vary significantly depending on the cell type and the experimental constraints, secondly the conformational landscape that leads to biased agonism has not been defined. Read More

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http://dx.doi.org/10.1515/bmc-2018-0013DOI Listing
December 2018
1 Read

Neural like cells and acetyl-salicylic acid alter rat brain structure and function following transient middle cerebral artery occlusion.

Biomol Concepts 2018 Dec 26;9(1):155-168. Epub 2018 Dec 26.

Neuroscience Research center, Shariati avenue, Tahmasbabad Cross, Kerman, Iran.

Introduction Transient cerebral ischemia is a pandemic neurological disorder and the main aim of medical intervention is to reduce complications. Human umbilical cord mesenchymal cells (hUCMs) are capable of differentiating into neural-like cells (NLC) in vitro, therefore we investigated the neuroprotective potential of these cells in comparison to aspirin and in combination (NLC-Aspirin) on spatial memory and neural morphologic changes in male rats submitted to transient cerebral ischemia. Methods Ten days after the intervention, the improvement in learning and memory were assessed in the animals by Morris Water Maze. Read More

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http://dx.doi.org/10.1515/bmc-2018-0014DOI Listing
December 2018
2 Reads

Insulin Promotes Wound Healing by Inactivating NFkβP50/P65 and Activating Protein and Lipid Biosynthesis and alternating Pro/Anti-inflammatory Cytokines Dynamics.

Biomol Concepts 2019 Feb 22;10(1):11-24. Epub 2019 Feb 22.

School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala-147004, Punjab, India.

Four hundred and twenty-two million people have diabetes due to excess free body glucose in their body fluids. Diabetes leads to various problems including retinopathy, neuropathy, arthritis, damage blood vessels etc; it also causes a delay in wound healing. Insufficiency of insulin is the main reason for diabetes-I and systemic insulin treatment is a remedy. Read More

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http://dx.doi.org/10.1515/bmc-2019-0002DOI Listing
February 2019
1 Read

When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics.

Biomol Concepts 2018 Dec 31;9(1):216-226. Epub 2018 Dec 31.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28040 Madrid, Spain.

Bacterial resistance to antibiotics poses enormous health and economic burdens to our society, and it is of the essence to explore old and new ways to deal with these problems. Here we review the current status of multi-resistance genes and how they spread among bacteria. We discuss strategies to deal with resistant bacteria, namely the search for new targets and the use of inhibitors of protein-protein interactions, fragment-based methods, or modified antisense RNAs. Read More

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http://dx.doi.org/10.1515/bmc-2018-0021DOI Listing
December 2018
1 Read

Prospects of Pharmacological Interventions to Organismal Aging.

Biomol Concepts 2018 Dec 31;9(1):200-215. Epub 2018 Dec 31.

School of Health, Sport and Bioscience, University of East London, Water Lane, E15 4LZ, London, United Kingdom.

Intense research in the areas of cellular and organismal aging using diverse laboratory model systems has enriched our knowledge in the processes and the signalling pathways involved in normal and pathological conditions. The field finds itself in a position to take decisive steps towards clinical applications and interventions not only for targeted age-related diseases such as cardiovascular conditions and neurodegeneration but also for the modulation of health span and lifespan of a whole organism. Beyond nutritional interventions such as dietary restriction without malnutrition and various regimes of intermittent fasting, accumulating evidence provides promise for pharmacological interventions. Read More

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http://dx.doi.org/10.1515/bmc-2018-0018DOI Listing
December 2018
1 Read

In vitro and in vivo evaluation of colon cancer targeted epichlorohydrin crosslinked Portulaca-alginate beads.

Biomol Concepts 2018 Dec 31;9(1):190-199. Epub 2018 Dec 31.

Sinhgad Technical Education Society's, Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune - 411 048, (affiliated to: Savitribai Phule Pune University),Maharashtra, India.

The aim of this study was to formulate a novel dual crosslinked hydrogel bead using Portulaca mucilage for colon-targeted delivery of 5-fluorouracil (5-FU) and evaluate its safety, specificity and efficacy. The ionotropic gelation technique was employed to prepare the hydrogel beads of Portulaca mucilage. For this, the mucilage was initially crosslinked with alginate and calcium ions. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0019DOI Listing
December 2018
6 Reads

Beneficial effects of Spirogyra Neglecta Extract on antioxidant and anti-inflammatory factors in streptozotocin-induced diabetic rats.

Biomol Concepts 2018 Dec 31;9(1):184-189. Epub 2018 Dec 31.

Research Centre of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Objectives This study was conducted to evaluate the effects of oral supplementation of Spirogyra algae on oxidative damages and inflammatory responses in streptozotocin (STZ)-induced diabetic rats. Methods Diabetes was induced by administration of 55 mg/kg of streptozotocin. A total of sixty-four rats were divided into eight groups of eight rats each as follows:1) non-diabetic control; 2, 3, and 4) non-diabetic rats treated with 15, 30, and 45 mg of Spirogyra algae/kg/d; 5) control diabetic; and 6, 7, and 8) diabetic rats treated with 15, 30, and 45 mg of Spirogyra algae extract. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0015DOI Listing
December 2018
3 Reads

Significance of bacteriophages in fermented soybeans: A review.

Biomol Concepts 2018 Nov 23;9(1):131-142. Epub 2018 Nov 23.

Department of Medical Biomaterials Engineering, Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.

Bacteriophages are ubiquitous and have been reported to have been found in many food products. Their presence is important as they have the ability to interact with their bacterial host in food matrices. Fermented soybean products, one of the most widely consumed ethnic foods among Asian people, are prepared naturally and include Japanese Natto, Indian Kinema, Korean Chongkukjang and Thai Thua Nao. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0012DOI Listing
November 2018
14 Reads

Early Life Trauma Predicts Affective Phenomenology and the Effects are Partly Mediated by Staging Coupled with Lowered Lipid-Associated Antioxidant Defences.

Biomol Concepts 2018 Nov 20;9(1):115-130. Epub 2018 Nov 20.

Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Av. Robert Koch 60; 86035-380, Londrina, PR, Brazil.

Background Early life trauma (ELT) may drive mood disorder phenomenology, nitro-oxidative pathways and impairments in semantic memory. There are no data regarding the impact of ELT on affective phenomenology and whether these pathways are mediated by staging or lowered lipid-associated antioxidant defences. Methods This study examined healthy controls (n=54) and patients with affective disorders including major depression, bipolar disorder and anxiety disorders (n=118). Read More

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http://dx.doi.org/10.1515/bmc-2018-0010DOI Listing
November 2018
5 Reads

The rise of genetically engineered mouse models of pancreatitis: A review of literature.

Biomol Concepts 2018 Nov 10;9(1):103-114. Epub 2018 Nov 10.

Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Pancreatitis is increasingly recognized as not merely a local inflammation of the pancreas but also a disease with high frequency of systemic sequelae. Current understanding of the cellular mechanisms that trigger it and affect the development of sequelae are limited. Genetically engineered mouse models can be a useful tool to study the pathophysiology of pancreatitis. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0011DOI Listing
November 2018
11 Reads

Small heat shock proteins and neurodegeneration: recent developments.

Biomol Concepts 2018 Aug 20;9(1):94-102. Epub 2018 Aug 20.

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, 70013, Crete, Greece.

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http://dx.doi.org/10.1515/bmc-2018-0009DOI Listing

Polymorphisms in DNA repair genes increase the risk for type 2 diabetes mellitus and hypertension.

Biomol Concepts 2018 Jun 9;9(1):80-93. Epub 2018 Jun 9.

Department of Biotechnology, Assam University, Silchar-788011, Assam, India.

We investigated the effect of polymorphisms in four DNA repair genes, viz. RAD18 Arg302Gln (G>A) (rs373572), XPD Asp312Asn (G>A) (rs1799793), APE1 Asp148Glu (T>G) (rs3136820), and OGG1 Ser326Cys (C>G) (rs1052133) on the risk for type 2 diabetes mellitus (T2DM) and hypertension (HT) in association with smoking, tobacco chewing, and alcohol consumption in a population from Northeast India. The study subjects were comprised of 70 patients suffering from both T2DM and HT and 83 healthy controls. Read More

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http://dx.doi.org/10.1515/bmc-2018-0008DOI Listing

Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases.

Biomol Concepts 2018 May 30;9(1):64-79. Epub 2018 May 30.

From the Infectious Disease Immunology Lab, Dr. B R Ambedkar Center for Biomedical Research, University of Delhi, Delhi, 110007, India.

A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous protective functions to heighten immune responses in infections and cancers. It can exhibit its immunomodulatory effects by enhancing antigen processing and presentation, increasing leukocyte trafficking, inducing an anti-viral state, boosting the anti-microbial functions and affecting cellular proliferation and apoptosis. A complex interplay between immune cell activity and IFN-γ through coordinated integration of signals from other pathways involving cytokines and Pattern Recognition Receptors (PRRs) such as Interleukin (IL)-4, TNF-α, Lipopolysaccharide (LPS), Type-I Interferons (IFNS) etc. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0007DOI Listing
May 2018
14 Reads

Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration.

Biomol Concepts 2018 May 19;9(1):43-52. Epub 2018 May 19.

Department of Orthopaedic Surgery, Augusta University, Augusta, GA, USA.

Chronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. Read More

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http://dx.doi.org/10.1515/bmc-2018-0003DOI Listing
May 2018
1 Read

Treatment of SEC62 over-expressing tumors by Thapsigargin and Trifluoperazine.

Biomol Concepts 2018 May 19;9(1):53-63. Epub 2018 May 19.

Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg/Saar, saabrucken, Germany.

Treatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to this treatment. Therefore, we proposed the novel concept that e. Read More

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http://dx.doi.org/10.1515/bmc-2018-0006DOI Listing
May 2018
1 Read

Global Perspective of Novel Therapeutic Strategies for the Management of NeuroAIDS.

Biomol Concepts 2018 May 8;9(1):33-42. Epub 2018 May 8.

Center for Advanced Research (CFAR)-Stem Cell/Cell Culture Unit, King George's Medical University (KGMU), Lucknow, 226003, India.

Among Human immunodeficiency virus (HIV) infected individuals, around two-thirds of patients present with neuroAIDS, where HIV-associated neurocognitive disorders (HAND), and HIV-associated dementia (HAD) are the most prevailing neurological complications. The neuropathology of neuroAIDS can be characterized by the presence of HIV infected macrophages and microglia in the brain, with the formation of multinucleated giant cells. Global predominant subtypes of HIV-1 clade B and C infections influence the differential effect of immune and neuronal dysfunctions, leading to clade-specific clinical variation in neuroAIDS patient cohorts. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0005DOI Listing
May 2018
26 Reads

Overexpression and pre-treatment of recombinant human Secretory Leukocyte Protease Inhibitor (rhSLPI) reduces an in vitro ischemia/reperfusion injury in rat cardiac myoblast (H9c2) cell.

Biomol Concepts 2018 May 4;9(1):17-32. Epub 2018 May 4.

Biomedical Research Unit in Cardiovascular Sciences (BRUCS), Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000, Thailand.

One of the major causes of cardiac cell death during myocardial ischemia is the oversecretion of protease enzymes surrounding the ischemic tissue. Therefore, inhibition of the protease activity could be an alternative strategy for preventing the expansion of the injured area. In the present study, we investigated the effects of Secretory Leukocyte Protease Inhibitor (SLPI), by means of overexpression and treatment of recombinant human SLPI (rhSLPI) in an in vitro model. Read More

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http://dx.doi.org/10.1515/bmc-2018-0004DOI Listing
May 2018
3 Reads

DNA testing of edible crabs from seafood shops on the Odisha coast, India.

Biomol Concepts 2018 Apr 20;9(1):12-16. Epub 2018 Apr 20.

Centre for DNA Taxonomy, Molecular Systematic Division, Zoological Survey of India, M Block, New Alipore, Kolkata-700053, West Bengal, India.

Seafood consumption is highly demanding due to the important source of protein it contains, as well as being rich in omega-3 fatty acids. However, the adulteration of seafood is an alarming issue worldwide, including India. This study deals with edible crabs from seafood shops on the Odisha state coast in eastern India. Read More

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http://dx.doi.org/10.1515/bmc-2018-0002DOI Listing
April 2018
8 Reads

Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro.

Biomol Concepts 2018 Mar 5;9(1):1-11. Epub 2018 Mar 5.

Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain.

The microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called "prion-like" manner. Read More

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http://dx.doi.org/10.1515/bmc-2018-0001DOI Listing
March 2018
1 Read

The impact of water on the ambivalent behavior and paradoxical phenomenon of the amyloid-β fibril protein.

Biomol Concepts 2017 Dec;8(5-6):213-220

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The crucial role of water in amyloid-β(Aβ) fibril proteins is evaluated in several ways including the water's thermodynamic and kinetic solvation effects. As regards the water's character, its hindered-rotation barriers are also considered. The following protein molecules considered here are: the Aβ40 (PDB ID: 2LMN), Aβ42 (PDB ID: 5KK3 and 2NAO) and the double-layered Aβ17-42 fibril. Read More

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http://www.degruyter.com/view/j/bmc.2017.8.issue-5-6/bmc-201
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http://dx.doi.org/10.1515/bmc-2017-0027DOI Listing
December 2017
3 Reads

Epigenetic regulation mechanisms of microRNA expression.

Biomol Concepts 2017 Dec;8(5-6):203-212

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MicroRNAs (miRNAs) are single-stranded RNAs of 18-25 nucleotides that regulate gene expression at the post-transcriptional level. They are involved in many physiological and pathological processes, including cell proliferation, apoptosis, development and carcinogenesis. Because of the central role of miRNAs in the regulation of gene expression, their expression needs to be tightly controlled. Read More

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http://dx.doi.org/10.1515/bmc-2017-0024DOI Listing
December 2017
2 Reads

Biotechnology of siderophores in high-impact scientific fields.

Biomol Concepts 2017 Sep;8(3-4):169-178

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Different aspects of bacterial and fungal siderophore biotechnological applications will be discussed. Areas of application presented include, but are not limited to agriculture, medicine, pharmacology, bioremediation, biodegradation and food industry. In agriculture-related applications, siderophores could be employed to enhance plant growth due to their uptake by rhizobia. Read More

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http://dx.doi.org/10.1515/bmc-2017-0016DOI Listing
September 2017
41 Reads

Mechanisms of tail resorption during anuran metamorphosis.

Biomol Concepts 2017 Sep;8(3-4):179-183

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Amphibian metamorphosis has historically attracted a good deal of scientific attention owing to its dramatic nature and easy observability. However, the genetic mechanisms of amphibian metamorphosis have not been thoroughly examined using modern techniques such as gene cloning, DNA sequencing, polymerase chain reaction or genomic editing. Here, we review the current state of knowledge regarding molecular mechanisms underlying tadpole tail resorption. Read More

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http://dx.doi.org/10.1515/bmc-2017-0022DOI Listing
September 2017
4 Reads

Breaking in and busting out: cell-penetrating peptides and the endosomal escape problem.

Biomol Concepts 2017 Sep;8(3-4):131-141

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Cell-penetrating peptides (CPPs) have long held great promise for the manipulation of living cells for therapeutic and research purposes. They allow a wide array of biomolecules from large, oligomeric proteins to nucleic acids and small molecules to rapidly and efficiently traverse cytoplasmic membranes. With few exceptions, if a molecule can be associated with a CPP, it can be delivered into a cell. Read More

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http://dx.doi.org/10.1515/bmc-2017-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640260PMC
September 2017
68 Reads

Protein kinase C-α and the regulation of diverse cell responses.

Biomol Concepts 2017 Sep;8(3-4):143-153

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Protein kinase C (PKC) comprises a family of lipid-sensitive enzymes that have been involved in a broad range of cellular functions. PKC-α is a member of classical PKC with ubiquitous expression and different cellular localization. This unique PKC isoform is activated by various signals which evoke lipid hydrolysis, after activation it interacts with various adapter proteins and is localized to specific cellular compartments where it is devised to work. Read More

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http://dx.doi.org/10.1515/bmc-2017-0005DOI Listing
September 2017
13 Reads

Role of TRAF3 in neurological and cardiovascular diseases: an overview of recent studies.

Biomol Concepts 2017 Sep;8(3-4):197-202

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Tumour necrosis factor receptor-associated factor 3 (TRAF3) is a member of the TRAF adaptor protein family, which exerts different effects on the cell depending on the receptor to which it binds and the cell type in which it is expressed. TRAF3 is a major regulator of the innate immune response. To perform its functions properly, TRAF3 is transcriptionally and epigenetically regulated. Read More

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http://dx.doi.org/10.1515/bmc-2017-0008DOI Listing
September 2017
2 Reads

Breastfeeding and the gut-brain axis: is there a role for melatonin?

Biomol Concepts 2017 Sep;8(3-4):185-195

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The benefits of breastfeeding over formula feed are widely appreciated. However, for many mothers breastfeeding is not possible, highlighting the need for a significant improvement in the contents of formula feed. In this article, the overlooked role of melatonin and the melatonergic pathways in breast milk and in the regulation of wider breast milk components are reviewed. Read More

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http://dx.doi.org/10.1515/bmc-2017-0009DOI Listing
September 2017
3 Reads

Assembly pathway of a bacterial complex iron sulfur molybdoenzyme.

Biomol Concepts 2017 Sep;8(3-4):155-167

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Protein folding and assembly into macromolecule complexes within the living cell are complex processes requiring intimate coordination. The biogenesis of complex iron sulfur molybdoenzymes (CISM) requires use of a system specific chaperone - a redox enzyme maturation protein (REMP) - to help mediate final folding and assembly. The CISM dimethyl sulfoxide (DMSO) reductase is a bacterial oxidoreductase that utilizes DMSO as a final electron acceptor for anaerobic respiration. Read More

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http://dx.doi.org/10.1515/bmc-2017-0011DOI Listing
September 2017
5 Reads

Recent advances in the mechanism of selenoamino acids toxicity in eukaryotic cells.

Biomol Concepts 2017 May;8(2):93-104

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Selenium is an essential trace element due to its incorporation into selenoproteins with important biological functions. However, at high doses it is toxic. Selenium toxicity is generally attributed to the induction of oxidative stress. Read More

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http://dx.doi.org/10.1515/bmc-2017-0007DOI Listing
May 2017
23 Reads

One-carbon metabolism and ionizing radiation: a multifaceted interaction.

Biomol Concepts 2017 May;8(2):83-92

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Ionizing radiation (IR) is a ubiquitous component of our environment and an important tool in research and medical treatment. At the same time, IR is a potent genotoxic and epigenotoxic stressor, exposure to which may lead to negative health outcomes. While the genotoxocity is well described and characterized, the epigenetic effects of exposure to IR and their mechanisms remain under-investigated. Read More

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http://dx.doi.org/10.1515/bmc-2017-0003DOI Listing
May 2017
7 Reads

Nitrophorins and nitrobindins: structure and function.

Biomol Concepts 2017 May;8(2):105-118

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Classical all α-helical globins are present in all living organisms and are ordered in three lineages: (i) flavohemoglobins and single domain globins, (ii) protoglobins and globin coupled sensors and (iii) truncated hemoglobins, displaying the 3/3 or the 2/2 all α-helical fold. However, over the last two decades, all β-barrel and mixed α-helical-β-barrel heme-proteins displaying heme-based functional properties (e.g. Read More

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http://dx.doi.org/10.1515/bmc-2017-0013DOI Listing
May 2017
26 Reads

Circulating cell-free microRNAs as clinical cancer biomarkers.

Biomol Concepts 2017 May;8(2):61-81

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MicroRNAs (miRNAs) are non-coding small RNAs that are master regulators of genic expression and consequently of many cellular processes. But their expression is often deregulated in human tumors leading to cancer development. Recently miRNAs were discovered in body fluids (serum, plasma and others) and their levels have often been reported to be altered in patients. Read More

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http://dx.doi.org/10.1515/bmc-2017-0002DOI Listing
May 2017
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Vascular calcification: the role of microRNAs.

Biomol Concepts 2017 May;8(2):119-123

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Vascular calcification represents the deposition of calcium phosphate salts in the tunica media of the vascular wall. It occurs during aging but is accelerated and pronounced in patients with diabetes mellitus, chronic kidney disease (CKD) and established cardiovascular disease. Due to the loss of elasticity of the vessel wall, vascular calcification might result in left ventricular hypertrophy and compromise coronary perfusion. Read More

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http://dx.doi.org/10.1515/bmc-2017-0001DOI Listing
May 2017
10 Reads

Differential hemoglobin A sequestration between hemodialysis modalities.

Biomol Concepts 2017 May;8(2):125-129

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This report evaluates plasma protein patterns, dialysates and protein analysis of used dialysis membranes from the same patient under hemodialysis in three separate modalities, using high-flux membranes in concentration-driven transport (HD), convection-driven hemofiltration (HF) and combined hemodialfiltration (HDF). The plasma protein changes induced by each of the three dialysis modalities showed small differences in proteins identified towards our previous plasma analyses of chronic kidney disease (CKD) patients. The used dialysate peptide concentrations likewise exhibited small differences among the modalities and varied in the same relative order as the plasma changes, with protein losses in the order HD>HDF>HF. Read More

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http://dx.doi.org/10.1515/bmc-2017-0006DOI Listing
May 2017
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SUMO conjugation - a mechanistic view.

Biomol Concepts 2017 Mar;8(1):13-36

The regulation of protein fate by modification with the small ubiquitin-related modifier (SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly dynamic due to the opposing activities of SUMO conjugation and SUMO deconjugation. SUMO conjugation is performed by the hierarchical action of E1, E2 and E3 enzymes, while its deconjugation involves SUMO-specific proteases. Read More

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http://dx.doi.org/10.1515/bmc-2016-0030DOI Listing
March 2017
5 Reads

Alzheimer's disease as an inflammatory disease.

Biomol Concepts 2017 Mar;8(1):37-43

Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration. Read More

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http://dx.doi.org/10.1515/bmc-2016-0029DOI Listing
March 2017
12 Reads

Optical tweezers studies of transcription by eukaryotic RNA polymerases.

Biomol Concepts 2017 Mar;8(1):1-11

Transcription is the first step in the expression of genetic information and it is carried out by large macromolecular enzymes called RNA polymerases. Transcription has been studied for many years and with a myriad of experimental techniques, ranging from bulk studies to high-resolution transcript sequencing. In this review, we emphasise the advantages of using single-molecule techniques, particularly optical tweezers, to study transcription dynamics. Read More

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http://dx.doi.org/10.1515/bmc-2016-0028DOI Listing
March 2017
7 Reads

Alzheimer's and Danish dementia peptides induce cataract and perturb retinal architecture in rats.

Biomol Concepts 2017 Mar;8(1):45-84

Familial Danish dementias (FDDs) are autosomal dominant neurodegenerative disorders that are associated with visual defects. In some aspects, FDD is similar to Alzheimer's disease (AD)- the amyloid deposits in FDD and AD are made of short peptides: amyloid β (Aβ) in AD and ADan in FDD. Previously, we demonstrated an interaction between the dementia peptides and α-crystallin leading to lens opacification in organ culture due to impaired chaperone activity of α-crystallin. Read More

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http://dx.doi.org/10.1515/bmc-2016-0025DOI Listing
March 2017
2 Reads

Interleukin-33 plasma levels in patients with relapsing-remitting multiple sclerosis.

Biomol Concepts 2017 Mar;8(1):55-60

Cytokines are implicated in the immunopathogenesis of multiple sclerosis (MS). Interleukin (IL)-33, one of the recently discovered members of the IL-1 superfamily, is a dual functional cytokine involved in various autoimmune disorders. In a case-control study, venous blood was collected from healthy subjects categorized as control group (n=44) and MS patients (n=44). Read More

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http://dx.doi.org/10.1515/bmc-2016-0026DOI Listing
March 2017
6 Reads

Unusual structures of CCTG repeats and their participation in repeat expansion.

Authors:
Pei Guo Sik Lok Lam

Biomol Concepts 2016 Dec;7(5-6):331-340

CCTG repeat expansion in intron 1 of the cellular nucleic acid-binding protein (CNBP) gene has been identified to be the genetic cause of myotonic dystrophy type 2 (DM2). Yet the underlying reasons for the genetic instability in CCTG repeats remain elusive. In recent years, CCTG repeats have been found to form various types of unusual secondary structures including mini-dumbbell (MDB), hairpin and dumbbell, revealing that there is a high structural diversity in CCTG repeats intrinsically. Read More

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http://dx.doi.org/10.1515/bmc-2016-0024DOI Listing
December 2016
4 Reads