364 results match your criteria Biomolecular concepts[Journal]


Insights into Endothelin-3 and Multiple Sclerosis.

Biomol Concepts 2020 Jun 25;11(1):137-141. Epub 2020 Jun 25.

Neurology and Neurophysiology Unit, Dpt. of Neurology and Human Movement Sciences, University Hospital of Siena, Santa Maria alle Scotte, Viale Bracci 2 53100 Siena, Italy.

Endothelins are powerful vasoconstrictor peptides that play numerous other roles. Endothelin-1 (ET1) is the principal isoform produced by the endothelium in the human cardiovascular system. Endothelin-3 (ET3) and its rPptor affinity have been demonstrated to support neuronal repair mechanisms throughout life. Read More

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http://dx.doi.org/10.1515/bmc-2020-0012DOI Listing

Genotypic distribution of human oncogenic papillomaviruses in sexually active women in Burkina Faso: Central, Central-Eastern and Hauts-Bassins regions.

Biomol Concepts 2020 May 17;11(1):125-136. Epub 2020 May 17.

Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Ouagadougou Burkina Faso.

Objective this study was conducted to determine the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women in the general population of three regions of Burkina Faso. Method This multicenter, descriptive cross-sectional study involved 1321 sexually active women in five cities in three regions of Burkina Faso: Central, Central-Eastern and Hauts-Bassins regions. After collection of endocervical specimens, pre-cervical lesions were screened by visual inspection with acetic acid and lugol (VIA / VILI). Read More

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http://dx.doi.org/10.1515/bmc-2020-0011DOI Listing

Polymorphism of MMP1 and MMP3 promoter regions and HR-HPV infection in women from Burkina Faso and Côte d'Ivoire.

Biomol Concepts 2020 May 17;11(1):116-124. Epub 2020 May 17.

Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph Ki-Zerbo, 03 BP 7021 Ouagadougou 03, Ouagadougou Burkina Faso.

The single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at 1607 bp) and MMP-3 (at 1171 bp) create Ets binding sites. Correlations between these SNPs and sensitivity to several biological processes such as metastasis and recurrence of cancer have been reported in several studies. In this case-control study, we looked for these SNPs in women infected with or not with high-risk human papillomaviruses (HR-HPV). Read More

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http://dx.doi.org/10.1515/bmc-2020-0010DOI Listing

Three-dimensional reconstruction of individual helical nano-filament structures from atomic force microscopy topographs.

Biomol Concepts 2020 May 6;11(1):102-115. Epub 2020 May 6.

Kent Fungal Group, School of Biosciences, University of Kent, CT2 7NJ, Canterbury, UK.

Atomic force microscopy, AFM, is a powerful tool that can produce detailed topographical images of individual nano-structures with a high signal-to-noise ratio without the need for ensemble averaging. However, the application of AFM in structural biology has been hampered by the tip-sample convolution effect, which distorts images of nano-structures, particularly those that are of similar dimensions to the cantilever probe tips used in AFM. Here we show that the tip-sample convolution results in a feature-dependent and non-uniform distribution of image resolution on AFM topographs. Read More

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http://dx.doi.org/10.1515/bmc-2020-0009DOI Listing

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine.

Biomol Concepts 2020 Apr 15;11(1):86-96. Epub 2020 Apr 15.

Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Département de Biochimie-Microbiologie, Université Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Ouagadougou Burkina Faso.

Objectives Natural products commonly used in traditional medicine, such as essential oils (EOs), are attractive sources for the development of molecules with anti-proliferative activities for future treatment of human cancers, e.g., prostate and cervical cancer. Read More

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http://dx.doi.org/10.1515/bmc-2020-0007DOI Listing

Association of TNF-α-308G/A and IL-18 Polymorphisms with risk of HPV infection among sexually active women in Burkina Faso.

Biomol Concepts 2020 Apr 15;11(1):97-101. Epub 2020 Apr 15.

Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Ouagadougou Burkina Faso.

Human papillomavirus (HPV) infection is the most common sexually transmitted infection worldwide. Persistence infection can lead to the development of cervical cancer potentially due to some genetic factors such as polymorphisms in regulatory and coding regions of cytokine genes. The purpose of this study was to determine whether there is a relationship between TNF-308 G/A or IL18 polymorphisms and high-risk HPV infection among sexually active women from Burkina Faso. Read More

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http://dx.doi.org/10.1515/bmc-2020-0008DOI Listing

Regulation of Interferon-γ receptor (IFN-γR) expression in macrophages during Mycobacterium tuberculosis infection.

Biomol Concepts 2020 Apr 6;11(1):76-85. Epub 2020 Apr 6.

From the Infectious Disease Immunology Lab, Dr. B R Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.

Interferon-gamma (IFN-γ) is a key cytokine that mediates immunity to tuberculosis (TB). Mycobacterium tuberculosis (M. tb) is known to downregulate the surface expression of IFN-γ receptor (IFN-γR) on macrophages and peripheral blood mononuclear cells (PBMCs) of patients with active TB disease. Read More

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http://dx.doi.org/10.1515/bmc-2020-0006DOI Listing

The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review.

Biomol Concepts 2020 Mar 26;11(1):57-75. Epub 2020 Mar 26.

Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran.

Background Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities in women. Due to the side effects of drugs, the tendency to use natural antioxidants and anti-inflammatory agents to regulate metabolism, hyperinsulinemia, and hyperlipidemia in PCOS patients has been increased. This review aimed to investigate the role of herbal substances on the treatment of PCOS. Read More

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http://dx.doi.org/10.1515/bmc-2020-0005DOI Listing

Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation.

Biomol Concepts 2020 Mar 17;11(1):32-56. Epub 2020 Mar 17.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India-781039.

The inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition constants. The acute onset of toxicity and CN's mg/Kg LD50 (μM lethal concentration) suggests that the classical hemeFe binding-based inhibition rationale is untenable to account for the toxicity of CN. In vitro mechanistic probing of CN-mediated inhibition of hemeFe reductionist systems was explored as a murburn model for mitochondrial oxidative phosphorylation (mOxPhos). Read More

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http://dx.doi.org/10.1515/bmc-2020-0004DOI Listing

Are the biomedical sciences ready for synthetic biology?

Biomol Concepts 2020 Jan 24;11(1):23-31. Epub 2020 Jan 24.

Cellular and Molecular Biology Graduate Program, University of Michigan Medical School, Ann Arbor, Michigan, USA.

The ability to construct a functional system from its individual components is foundational to understanding how it works. Synthetic biology is a broad field that draws from principles of engineering and computer science to create new biological systems or parts with novel function. While this has drawn well-deserved acclaim within the biotechnology community, application of synthetic biology methodologies to study biological systems has potential to fundamentally change how biomedical research is conducted by providing researchers with improved experimental control. Read More

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http://dx.doi.org/10.1515/bmc-2020-0003DOI Listing
January 2020

Murburn concept: a paradigm shift in cellular metabolism and physiology.

Biomol Concepts 2020 Jan 22;11(1):7-22. Epub 2020 Jan 22.

Satyamjayatu: The Science & Ethics Foundation,Snehatheeram, Kulappully, Shoranur-2 (PO), Kerala,India-679122.

Two decades of evidence-based exploratory pursuits in heme-flavin enzymology led to the formulation of a new biological electron/moiety transfer paradigm, called murburn concept. Murburn is a novel literary abstraction from "mured burning" or "mild unrestricted burning". This concept was invoked to explain the longstanding conundrum of maverick physiological dose responses and also applied to remodel the prevailing understanding of drug metabolism and cellular respiration. Read More

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http://dx.doi.org/10.1515/bmc-2020-0002DOI Listing
January 2020

A new biological definition of life.

Biomol Concepts 2020 Jan 13;11(1):1-6. Epub 2020 Jan 13.

Human Microbiology Institute, 101 Avenue of Americas, New York, NY 10013, United States of America.

Here we have proposed a new biological definition of life based on the function and reproduction of existing genes and creation of new ones, which is applicable to both unicellular and multicellular organisms. First, we coined a new term "genetic information metabolism" comprising functioning, reproduction, and creation of genes and their distribution among living and non-living carriers of genetic information. Encompassing this concept, life is defined as organized matter that provides genetic information metabolism. Read More

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http://dx.doi.org/10.1515/bmc-2020-0001DOI Listing
January 2020

Role of Killer cell immunoglobulin-like receptors (KIR) genes in stages of HIV-1 infection among patients from Burkina Faso.

Biomol Concepts 2019 Dec 19;10(1):226-236. Epub 2019 Dec 19.

Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.

Objectives A cluster of specialized KIR genes of specialized KIR genes has been shown to be associated with susceptibility or resistance to viral infections in humans. Therefore, this pilot study, this pilot investigation sought to determine the frequencies of KIR genes human immunodeficiency virus type 1( HIV-1) patients and establish their potential clinical involvement in disease progression and staging. Methods HIV-1 infected and healthy individuals were selected for this study. Read More

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http://dx.doi.org/10.1515/bmc-2019-0024DOI Listing
December 2019

The effect of rs9930506 FTO gene polymorphism on obesity risk: a meta-analysis.

Biomol Concepts 2019 Dec;10(1):237-242

Student Research Committee, Guilan University of Medical Sciences, Rasht, Iran.

Obesity is associated with polymorphisms of the fat mass and obesity associated gene (FTO). This meta-analysis aimed to investigate the association of the rs9930506 FTO gene polymorphism and obesity. To the best of our knowledge, this study is the first meta-analysis to evaluate the relation between FTO rs9930506 polymorphism and obesity. Read More

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http://dx.doi.org/10.1515/bmc-2019-0025DOI Listing
December 2019

Mechanochemistry of von Willebrand factor.

Biomol Concepts 2019 11 27;10(1):194-208. Epub 2019 Nov 27.

Servizio Malattie Emorragiche e Trombotiche, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Roma, Italy.

Von Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight, plays a crucial role in the primary haemostasis, the physiological process characterized by the adhesion of blood platelets to the injured vessel wall. Hydrodynamic forces are responsible for extensive conformational transitions in the VWF multimers that change their structure from a globular form to a stretched linear conformation. This feature makes this protein particularly prone to be investigated by mechanochemistry, the branch of the biophysical chemistry devoted to investigating the effects of shear forces on protein conformation. Read More

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http://dx.doi.org/10.1515/bmc-2019-0022DOI Listing
November 2019

Incidence of viruses infecting pepper in Thailand.

Biomol Concepts 2019 Nov 19;10(1):184-193. Epub 2019 Nov 19.

School of Science, Mae Fah Luang University, Chiang Rai 57100, Chiang Rai, Thailand.

This study was conducted to determine the incidence, diversity and distribution of viruses infecting pepper (Capsicum spp.) in the central, northern and northeastern parts of Thailand. During a survey in 2016 - 2019, a total of 2,149 leaf samples from symptomatic and asymptomatic peppers were collected randomly from farmer's fields, and preliminary tested by an enzyme-linked immunosorbent assay (ELISA) using 7 antibodies specific for cucumber mosaic virus (CMV), chilli veinal mottle virus (ChiVMV), tomato necrotic ringspot virus (TNRV), tobacco mosaic virus (TMV), potato virus Y (PVY), tomato spotted wilt virus (TSWV), and begomoviruses. Read More

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http://dx.doi.org/10.1515/bmc-2019-0021DOI Listing
November 2019

Schizophrenia phenomenology comprises a bifactorial general severity and a single-group factor, which are differently associated with neurotoxic immune and immune-regulatory pathways.

Biomol Concepts 2019 Nov 17;10(1):209-225. Epub 2019 Nov 17.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

In schizophrenia, a single latent trait underlies psychosis, hostility, excitation, mannerism, negative (PHEMN) symptoms, formal thought disorders (FTD) and psychomotor retardation (PMR). Schizophrenia is accompanied by a breakdown of gut and blood-brain-barrier (BBB) pathways, increased tryptophan catabolite (TRYCAT) levels, bacterial translocation, and lowered natural IgM and paraoxonase (PON)1 activity. The aim of this study was to examine the factor structure of schizophrenia symptom domains and the biomarker correlates of these factors. Read More

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http://dx.doi.org/10.1515/bmc-2019-0023DOI Listing
November 2019

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) variants and breast cancer risk in Burkina Faso.

Biomol Concepts 2019 Nov 9;10(1):175-183. Epub 2019 Nov 9.

Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR/SVT, University Joseph Ki-Zerbo, 03 P.O. Box 7021, Ouagadougou 03, Ouagadougou, Burkina Faso.

Background and objective Breast cancer remains the most common cause of cancer mortality in women. The aim of this study was to investigate associations between genetic variability in GSTM1 and GSTT1 and susceptibility to breast cancer. Methods Genomic DNA was extracted from blood samples for 80 cases of histologically diagnosed breast cancer and 100 control subjects. Read More

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http://dx.doi.org/10.1515/bmc-2019-0020DOI Listing
November 2019

Role of Nanomedicine in Redox Mediated Healing at Molecular Level.

Biomol Concepts 2019 Oct 29;10(1):160-174. Epub 2019 Oct 29.

Department of Chemical Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata-700106, India.

Nanomedicine, the offspring born from the marriage of nanotechnology and medicine, has already brought momentous advances in the fight against a plethora of unmet diseases from cardiovascular and neurodegenerative to diabetes and cancer. Here, we review a conceptual framework that will provide a basic understanding about the molecular mechanism of action of a therapeutic nanomaterial inside biological milieu. In this review, we highlight how the catalytic nature of a transition metal oxide nanomaterial influences the cellular redox homeostasis, supports the cellular antioxidant defence system and reactivates the reactive oxygen species (ROS) mediated signalling to perform normal cell functions like cell cycle, differentiation, apoptosis, inflammation, toxicity, and protein interactions. Read More

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http://dx.doi.org/10.1515/bmc-2019-0019DOI Listing
October 2019
1 Read

Integral membrane protein expression of human CD25 on the cell surface of HEK293 cell line: the available cellular model of CD25 positive to facilitate in vitro developing assays.

Biomol Concepts 2019 Sep 21;10(1):150-159. Epub 2019 Sep 21.

Institute of Hematology, Peking Union Medical College, Beijing, China.

Typically, CD25 is expressed on the cellular surface of regulatory T (Treg) cells. These cells are significant in regulating the self-tolerance and also preventing the immune system from attacking a person's own tissues and cells. They promote the cancer progression by playing an important role in evading the immune system. Read More

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http://dx.doi.org/10.1515/bmc-2019-0018DOI Listing
September 2019

Advances in Molecular biomarker for early diagnosis of Osteoarthritis.

Biomol Concepts 2019 Aug 9;10(1):111-119. Epub 2019 Aug 9.

Department of Orthopedics, Augusta University, Augusta, GA.

Osteoarthritis (OA) is a chronic degenerative joint disease. The pathogenesis is poorly understood. What is known is that OA is characterized by imbalance in anabolic and catabolic gene expression in articular chondrocytes. Read More

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http://dx.doi.org/10.1515/bmc-2019-0014DOI Listing
August 2019
4 Reads

Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation.

Authors:
George Anderson

Biomol Concepts 2019 Jul 19;10(1):133-149. Epub 2019 Jul 19.

CRC Scotland & London, Eccleston Square, London, UK.

Endometriosis is a common, often painful, condition that has significant implications for a woman's fertility. Classically, endometriosis has been conceptualized as a local estrogen-mediated uterine condition driven by retrograde menstruation. However, recent work suggests that endometriosis may be a systemic condition modulated, if not driven, by prenatal processes. Read More

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http://dx.doi.org/10.1515/bmc-2019-0017DOI Listing
July 2019
7 Reads

Ultrasonography in the diagnosis of lung adhesion before surgery.

Biomol Concepts 2019 Jul 12;10(1):128-132. Epub 2019 Jul 12.

Student Research Committee, Qom University of Medical Sciences, Qom, Iran.

Background The presence of pleural adhesions may render video-assisted thoracoscopic surgery difficult or impossible. The aim of this study was to assess the value of chest ultrasonography in the detection of pleural adhesions prior to thoracotomy. Methods Between 2013 and 2014, 42 consecutive patients undergoing thoracotomies (including video-assisted thoracicsurgery) were evaluated with chest ultrasonography. Read More

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http://dx.doi.org/10.1515/bmc-2019-0016DOI Listing

Evaluation of Quality of Life in Terms of Sinonasal Symptoms in Children with Cystic Fibrosis.

Biomol Concepts 2019 Jun 17;10(1):91-98. Epub 2019 Jun 17.

Mycobacteriology Research Center, National, Tehran, Iran.

Objective Sinusitis is a common complaint in children with cystic fibrosis. However, the actual prevalence of chronic rhinosinusitis and its effect on the quality of life of children have not been well considered. Therefore, the objective of this study was to determine the effect of sinonasal quality of life in children with cystic fibrosis. Read More

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http://dx.doi.org/10.1515/bmc-2019-0011DOI Listing
June 2019
11 Reads

Identification of BRCA1/2 p.Ser1613Gly, p.Pro871Leu, p.Lys1183Arg, p.Glu1038Gly, p.Ser1140Gly, p.Ala2466Val, p.His2440Arg variants in women under 45 years old with breast nodules suspected of having breast cancer in Burkina Faso.

Biomol Concepts 2019 Jun 11;10(1):120-127. Epub 2019 Jun 11.

Hôpital Saint Camille, Ouagadougou, 09 BP 444, Burkina Faso.

Breast cancer is the top cause of cancer mortality among women in the world and the second in Africa. The aims of this study were to: i) identify women with breast nodules suspected of having breast cancer ii) sequence the BRCA1 and BRCA2 genes and iii) screen mutations. From 2015 to 2016, 112 women aged from 35 to 44 years, who had come for consultation in the gynecology/obstetrics and the oncology department of the University Hospital Yalgado Ouedraogo, voluntarily agreed to participate to this study. Read More

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http://dx.doi.org/10.1515/bmc-2019-0015DOI Listing
June 2019
4 Reads

Diagnosis of Primary Hydatid Cyst of Thyroid Gland: A Case Report.

Biomol Concepts 2019 Jun 3;10(1):106-110. Epub 2019 Jun 3.

Dept. of Medical Microbiology and Immunology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.

A 34-year-old female patient was presented to the general surgery clinic of the hospital complaining of a growing tangible swelling in her neck. In physical examination, the patient had two palpable soft nodules in the left lobe of the thyroid which hadn't invaded the surrounding tissues. The function of thyroid gland was normal and fine needle aspiration (FNA) result reported it benign. Read More

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http://dx.doi.org/10.1515/bmc-2019-0013DOI Listing
June 2019
2 Reads

The Effect of Fine needle aspiration on Detecting Malignancy in Thyroid Nodule.

Biomol Concepts 2019 Jun 3;10(1):99-105. Epub 2019 Jun 3.

Internal Medicine Department, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Introduction The prevalence of thyroid nodules is 4-7% in adults. Although less than 5% of nodules in adults are malignant, most nodules are non-neoplastic or benign. Fine needle aspiration (FNA) is a diagnostic technique for evaluation of non-toxic nodules, which has been widely accepted. Read More

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http://dx.doi.org/10.1515/bmc-2019-0012DOI Listing
June 2019
3 Reads

Only serum pepsinogen I and pepsinogen I/II ratio are specific and sensitive biomarkers for screening of gastric cancer.

Biomol Concepts 2019 May 31;10(1):82-90. Epub 2019 May 31.

Caspian Digestive Diseases Research Center,Guilan University of Medical Sciences, Rasht, Iran.

Purpose We aimed to determine optimal cut-off points of plasma levels of ghrelin and serum levels of pepsinogen I, II, and their ratio for screening of gastric cancer (GC). Methods Blood samples were taken from 41 patients with confirmed gastric cancer along with 82 patients without malignancy. Serum levels of pepsinogen I and II, plus plasma levels of acylated ghrelin were measured using commercial ELISA kits. Read More

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http://dx.doi.org/10.1515/bmc-2019-0010DOI Listing
May 2019
2 Reads

Neurotoxic Effects of Stanozolol on Male Rats' Hippocampi: Does Stanozolol cause apoptosis?

Biomol Concepts 2019 Apr 20;10(1):73-81. Epub 2019 Apr 20.

Mashhad University of Medical Sciences, Mashhad, Iran.

Stanozolol is an anabolic-androgenic steroid which is commonly abused by athletes for improved energy, appearance, and physical size. It has been previously shown to cause changes in behaviour and has various physical effects. Studies have previously been conducted on its neurotoxic effect on the central nervous system (CNS), which are typically psychological in nature. Read More

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http://dx.doi.org/10.1515/bmc-2019-0009DOI Listing
April 2019
7 Reads

Pre-operative laparoscopic staging of gastric cancer in patients who are candidates for neo-adjuvant chemotherapy: A Cross Sectional Study.

Biomol Concepts 2019 Apr 16;10(1):68-72. Epub 2019 Apr 16.

General Physician, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective The aim of this study is to evaluate the laparoscopic method in gastric cancer staging before surgery in patients undergoing Neo-adjuvant chemotherapy. Methods This was a cross-sectional study on patients with T3-T4 and node positive non-metastatic gastric adenocarcinoma who was candidates for neo-adjuvant chemotherapy. The patients were excluded from the study when they were not in the condition to continue the study. Read More

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http://dx.doi.org/10.1515/bmc-2019-0008DOI Listing
April 2019
1 Read

Expression of OX40 Gene and its Serum Levels in Neuromyelitis Optica Patients.

Biomol Concepts 2019 Apr 11;10(1):62-67. Epub 2019 Apr 11.

Isfahan Neuroscience Research Center, Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Neuromyelitis optica (NMO), also known as Devic's disease, is an autoimmune disorder of the central nervous system (CNS) in which immune system cells and antibodies primarily attack the optic nerves and the spinal cord. OX40 (CD134) is a tumor necrosis factor (TNF)-receptor family member expressed primarily on activated CD4+ and CD8+ T-cells. In an autoimmune disease, OX40 is typically up-regulated at sites of inflammation, and increases in the number of peripheral CD4+ T-cells expressing OX40. Read More

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http://www.degruyter.com/view/j/bmc.2019.10.issue-1/bmc-2019
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http://dx.doi.org/10.1515/bmc-2019-0007DOI Listing
April 2019
11 Reads

The disordered boundary of the cell: emerging properties of membrane-bound intrinsically disordered proteins.

Biomol Concepts 2019 Apr 3;10(1):25-36. Epub 2019 Apr 3.

BioNMR Laboratory, Inorganic and Organic Chemistry Department, University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain.

We define the disordered boundary of the cell (DBC) as the system formed by membrane tethered intrinsically disordered protein regions, dynamically coupled to the underlying membrane. The emerging properties of the DBC makes it a global system of study, which cannot be understood from the individual properties of their components. Similarly, the properties of lipid bilayers cannot be understood from just the sum of the properties of individual lipid molecules. Read More

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http://dx.doi.org/10.1515/bmc-2019-0003DOI Listing

Zinc enhances the expression of morphine-induced conditioned place preference through dopaminergic and serotonergic systems.

Biomol Concepts 2019 Apr 3;10(1):51-61. Epub 2019 Apr 3.

Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran.

The antidepressant-like effects of zinc (Zn) have been documented in some animal models of depression. In addition, antidepressants may reduce the abuse potential of opioids by affecting their rewarding effect. Hence, this study was performed to investigate the effect of Zn on the expression of morphine-induced conditioned place preference (CPP) in male rats. Read More

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http://dx.doi.org/10.1515/bmc-2019-0006DOI Listing
April 2019
12 Reads

Comparison of the effect of vitamin D on osteoporosis and osteoporotic patients with healthy individuals referred to the Bone Density Measurement Center.

Biomol Concepts 2019 Apr 3;10(1):44-50. Epub 2019 Apr 3.

Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran.

Objective Osteoporosis is the most common metabolic disease of the bones. Osteoporosis reduces bone density, predisposes a person to fractures, and imposes high costs on societies. Osteoporosis develops from a variety of causes, one of the most significant is vitamin D deficiency. Read More

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http://dx.doi.org/10.1515/bmc-2019-0005DOI Listing
April 2019
2 Reads

ATP Synthase: Structure, Function and Inhibition.

Biomol Concepts 2019 Mar 7;10(1):1-10. Epub 2019 Mar 7.

Department of Biotechnology, Kathmandu University Dhulikhel, Nepal India.

Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria. A multi subunit structure that works like a pump functions along the proton gradient across the membranes which not only results in ATP synthesis and breakdown, but also facilitates electron transport. Read More

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http://dx.doi.org/10.1515/bmc-2019-0001DOI Listing
March 2019
2 Reads

Antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae in Streptozotocin-induced diabetic rats.

Biomol Concepts 2019 Mar 11;10(1):37-43. Epub 2019 Mar 11.

Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.

Background It is well documented that biologically active components of microalgae can be utilized for treatment of different diseases. This study was conducted to evaluate the antihyperglycemic and antihyperlipidemic activities and weight control of Nannochloropsis oculata microalgae (NOM) in Streptozotocin-induced diabetic male rats. Methods Diabetes was induced by intraperitoneal administration of Streptozotocin (55 mg/kg). Read More

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http://dx.doi.org/10.1515/bmc-2019-0004DOI Listing
March 2019
1 Read

Enhancing the anticoagulant profile of meizothrombin.

Biomol Concepts 2018 Dec 26;9(1):169-175. Epub 2018 Dec 26.

Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104 USA.

Meizothrombin is an active intermediate generated during the proteolytic activation of prothrombin to thrombin in the penultimate step of the coagulation cascade. Structurally, meizothrombin differs from thrombin because it retains the auxiliary Gla domain and two kringles. Functionally, meizothrombin shares with thrombin the ability to cleave procoagulant (fibrinogen), prothrombotic (PAR1) and anticoagulant (protein C) substrates, although its specificity toward fibrinogen and PAR1 is less pronounced. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
Publisher Site
http://dx.doi.org/10.1515/bmc-2018-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825329PMC
December 2018
18 Reads

Can uterine secretion of modified histones alter blastocyst implantation, embryo nutrition, and transgenerational phenotype?

Biomol Concepts 2018 Dec 26;9(1):176-183. Epub 2018 Dec 26.

Assistant Professor of Molecular Biology, Department of Biomedical Sciences, RVU, 8401 S. Chambers Road, Parker, CO 80134, USA.

Extracellular histones support rodent and human embryo development in at least two ways. First, these molecules in uterine secretions protect embryos from inflammation caused by pathogens that gain access to the reproductive tract. Also, histones in uterine secretions likely support penetration of the uterine epithelium by blastocysts during embryo implantation. Read More

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http://dx.doi.org/10.1515/bmc-2018-0017DOI Listing
December 2018
2 Reads

Biased receptor functionality versus biased agonism in G-protein-coupled receptors.

Biomol Concepts 2018 Dec 26;9(1):143-154. Epub 2018 Dec 26.

Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.

Functional selectivity is a property of G-protein-coupled receptors (GPCRs) by which activation by different agonists leads to different signal transduction mechanisms. This phenomenon is also known as biased agonism and has attracted the interest of drug discovery programs in both academy and industry. This relatively recent concept has raised concerns as to the validity and real translational value of the results showing bias; firstly biased agonism may vary significantly depending on the cell type and the experimental constraints, secondly the conformational landscape that leads to biased agonism has not been defined. Read More

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http://dx.doi.org/10.1515/bmc-2018-0013DOI Listing
December 2018
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Neural like cells and acetyl-salicylic acid alter rat brain structure and function following transient middle cerebral artery occlusion.

Biomol Concepts 2018 Dec 26;9(1):155-168. Epub 2018 Dec 26.

Neuroscience Research center, Shariati avenue, Tahmasbabad Cross, Kerman, Iran.

Introduction Transient cerebral ischemia is a pandemic neurological disorder and the main aim of medical intervention is to reduce complications. Human umbilical cord mesenchymal cells (hUCMs) are capable of differentiating into neural-like cells (NLC) in vitro, therefore we investigated the neuroprotective potential of these cells in comparison to aspirin and in combination (NLC-Aspirin) on spatial memory and neural morphologic changes in male rats submitted to transient cerebral ischemia. Methods Ten days after the intervention, the improvement in learning and memory were assessed in the animals by Morris Water Maze. Read More

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http://dx.doi.org/10.1515/bmc-2018-0014DOI Listing
December 2018
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Insulin Promotes Wound Healing by Inactivating NFkβP50/P65 and Activating Protein and Lipid Biosynthesis and alternating Pro/Anti-inflammatory Cytokines Dynamics.

Biomol Concepts 2019 Feb 22;10(1):11-24. Epub 2019 Feb 22.

School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala-147004, Punjab, India.

Four hundred and twenty-two million people have diabetes due to excess free body glucose in their body fluids. Diabetes leads to various problems including retinopathy, neuropathy, arthritis, damage blood vessels etc; it also causes a delay in wound healing. Insufficiency of insulin is the main reason for diabetes-I and systemic insulin treatment is a remedy. Read More

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http://dx.doi.org/10.1515/bmc-2019-0002DOI Listing
February 2019
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When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics.

Biomol Concepts 2018 Dec 31;9(1):216-226. Epub 2018 Dec 31.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28040 Madrid, Spain.

Bacterial resistance to antibiotics poses enormous health and economic burdens to our society, and it is of the essence to explore old and new ways to deal with these problems. Here we review the current status of multi-resistance genes and how they spread among bacteria. We discuss strategies to deal with resistant bacteria, namely the search for new targets and the use of inhibitors of protein-protein interactions, fragment-based methods, or modified antisense RNAs. Read More

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http://dx.doi.org/10.1515/bmc-2018-0021DOI Listing
December 2018
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Prospects of Pharmacological Interventions to Organismal Aging.

Biomol Concepts 2018 Dec 31;9(1):200-215. Epub 2018 Dec 31.

School of Health, Sport and Bioscience, University of East London, Water Lane, E15 4LZ, London, United Kingdom.

Intense research in the areas of cellular and organismal aging using diverse laboratory model systems has enriched our knowledge in the processes and the signalling pathways involved in normal and pathological conditions. The field finds itself in a position to take decisive steps towards clinical applications and interventions not only for targeted age-related diseases such as cardiovascular conditions and neurodegeneration but also for the modulation of health span and lifespan of a whole organism. Beyond nutritional interventions such as dietary restriction without malnutrition and various regimes of intermittent fasting, accumulating evidence provides promise for pharmacological interventions. Read More

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http://dx.doi.org/10.1515/bmc-2018-0018DOI Listing
December 2018
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In vitro and in vivo evaluation of colon cancer targeted epichlorohydrin crosslinked Portulaca-alginate beads.

Biomol Concepts 2018 Dec 31;9(1):190-199. Epub 2018 Dec 31.

Sinhgad Technical Education Society's, Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune - 411 048, (affiliated to: Savitribai Phule Pune University),Maharashtra, India.

The aim of this study was to formulate a novel dual crosslinked hydrogel bead using Portulaca mucilage for colon-targeted delivery of 5-fluorouracil (5-FU) and evaluate its safety, specificity and efficacy. The ionotropic gelation technique was employed to prepare the hydrogel beads of Portulaca mucilage. For this, the mucilage was initially crosslinked with alginate and calcium ions. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0019DOI Listing
December 2018
7 Reads

Beneficial effects of Spirogyra Neglecta Extract on antioxidant and anti-inflammatory factors in streptozotocin-induced diabetic rats.

Biomol Concepts 2018 Dec 31;9(1):184-189. Epub 2018 Dec 31.

Research Centre of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Objectives This study was conducted to evaluate the effects of oral supplementation of Spirogyra algae on oxidative damages and inflammatory responses in streptozotocin (STZ)-induced diabetic rats. Methods Diabetes was induced by administration of 55 mg/kg of streptozotocin. A total of sixty-four rats were divided into eight groups of eight rats each as follows:1) non-diabetic control; 2, 3, and 4) non-diabetic rats treated with 15, 30, and 45 mg of Spirogyra algae/kg/d; 5) control diabetic; and 6, 7, and 8) diabetic rats treated with 15, 30, and 45 mg of Spirogyra algae extract. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0015DOI Listing
December 2018
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Significance of bacteriophages in fermented soybeans: A review.

Biomol Concepts 2018 Nov 23;9(1):131-142. Epub 2018 Nov 23.

Department of Medical Biomaterials Engineering, Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea.

Bacteriophages are ubiquitous and have been reported to have been found in many food products. Their presence is important as they have the ability to interact with their bacterial host in food matrices. Fermented soybean products, one of the most widely consumed ethnic foods among Asian people, are prepared naturally and include Japanese Natto, Indian Kinema, Korean Chongkukjang and Thai Thua Nao. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0012DOI Listing
November 2018
30 Reads

Early Life Trauma Predicts Affective Phenomenology and the Effects are Partly Mediated by Staging Coupled with Lowered Lipid-Associated Antioxidant Defences.

Biomol Concepts 2018 Nov 20;9(1):115-130. Epub 2018 Nov 20.

Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Av. Robert Koch 60; 86035-380, Londrina, PR, Brazil.

Background Early life trauma (ELT) may drive mood disorder phenomenology, nitro-oxidative pathways and impairments in semantic memory. There are no data regarding the impact of ELT on affective phenomenology and whether these pathways are mediated by staging or lowered lipid-associated antioxidant defences. Methods This study examined healthy controls (n=54) and patients with affective disorders including major depression, bipolar disorder and anxiety disorders (n=118). Read More

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http://dx.doi.org/10.1515/bmc-2018-0010DOI Listing
November 2018
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The rise of genetically engineered mouse models of pancreatitis: A review of literature.

Biomol Concepts 2018 Nov 10;9(1):103-114. Epub 2018 Nov 10.

Department of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Pancreatitis is increasingly recognized as not merely a local inflammation of the pancreas but also a disease with high frequency of systemic sequelae. Current understanding of the cellular mechanisms that trigger it and affect the development of sequelae are limited. Genetically engineered mouse models can be a useful tool to study the pathophysiology of pancreatitis. Read More

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http://www.degruyter.com/view/j/bmc.2018.9.issue-1/bmc-2018-
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http://dx.doi.org/10.1515/bmc-2018-0011DOI Listing
November 2018
26 Reads

Small heat shock proteins and neurodegeneration: recent developments.

Biomol Concepts 2018 Aug 20;9(1):94-102. Epub 2018 Aug 20.

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, 70013, Crete, Greece.

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http://dx.doi.org/10.1515/bmc-2018-0009DOI Listing
August 2018
1 Read