9,815 results match your criteria Biometrics & biostatistics international journal[Journal]


Differentiating the geographical origin of Ethiopian coffee using XRF- and ICP-based multi-element and stable isotope profiling.

Food Chem 2019 Aug 27;290:295-307. Epub 2019 Mar 27.

Isotope Bioscience Laboratory - ISOFYS, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Gent, Belgium.

To test the potential of different analytical tools to determine the geographical origin of Ethiopian coffee, 103 green arabica coffee samples from four coffee regions in Ethiopia were subjected to multi-elements and δC, δN and δO determinations. Multi-elements were determined by using inductively coupled plasma (ICP)- and X-ray fluorescence spectrometry (XRF)-based techniques, and δC, δN and δO were determined by using elemental analyzer-isotope ratio mass spectrometry. Using linear discriminant analysis, XRF-based multi-elements with and without δC appeared to be most effective in discriminating the geographical origin of coffee, giving higher classification accuracy (89 and 86%, respectively) than ICP-based multi-elements with and without stable isotopes (80%, each). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03088146193062
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http://dx.doi.org/10.1016/j.foodchem.2019.03.135DOI Listing
August 2019
1 Read

Assessing alignment between functional markers and ordinal outcomes based on broad sense agreement.

Biometrics 2019 Apr 18. Epub 2019 Apr 18.

Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.

Functional markers and their quantitative features (eg, maximum value, time to maximum, area under the curve [AUC], etc) are increasingly being used in clinical studies to diagnose diseases. It is thus of interest to assess the diagnostic utility of functional markers by assessing alignment between their quantitative features and an ordinal gold standard test that reflects the severity of disease. The concept of broad sense agreement (BSA) has recently been introduced for studying the relationship between continuous and ordinal measurements, and provides a promising tool to address such a question. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13063
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http://dx.doi.org/10.1111/biom.13063DOI Listing
April 2019
1 Read

Correlation between incremental remifentanil doses and the Nociception Level (NOL) index response after intraoperative noxious stimuli.

Can J Anaesth 2019 Apr 17. Epub 2019 Apr 17.

Department of Anesthesiology of Maisonneuve-Rosemont Hospital, CIUSSS de l'Est de l'Ile de Montreal, University of Montreal, 5415 Boulevard de l'Assomption, Montreal, QC, H1T 2M4, Canada.

Background: The Pain Monitoring Device (PMD) monitor (Medasense Biometrics Ltd., Ramat Gan, Israel) uses the Nociception Level (NOL) index, a multiple parameter-derived index that has recently shown a good sensitivity and specificity to detect noxious stimuli. The aim of this study was to assess the latest version of the device (PMD200) on variations of the NOL response after standardized tetanic stimuli to study the correlation between remifentanil doses and NOL. Read More

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http://link.springer.com/10.1007/s12630-019-01372-1
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http://dx.doi.org/10.1007/s12630-019-01372-1DOI Listing
April 2019
1 Read

[Advances in epigenetic markers of dermatomyositis/polymyositis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):374-377

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. Read More

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April 2019
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Distribution of Trichinella spiralis in the Diaphragm of Experimentally Infected Swine.

J Food Prot 1988 Sep;51(9):691-695

Meat Science Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Building 201, BARC-East, Beltsville, Maryland 20705 and Walter Reed Army Institute of Research, Division of Biometrics, Washington, D.C.

The objectives of this study were to determine whether the distribution of Trichinella spiralis larvae within the diaphragm of infected swine was the same throughout five anatomically identifiable portions, and to assess the tenability of the Poisson model to describe the probability of detecting larvae in samples of digested tissue. To examine differences in levels of infection among the regions of the diaphragm, sixteen 2-month-old and fourteen 6-month-old swine were infected with approximately 300 T. spiralis larvae per animal. Read More

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http://dx.doi.org/10.4315/0362-028X-51.9.691DOI Listing
September 1988

Prediction analysis for microbiome sequencing data.

Biometrics 2019 Apr 17. Epub 2019 Apr 17.

SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.

One goal of human microbiome studies is to relate host traits with human microbiome compositions. The analysis of microbial community sequencing data presents great statistical challenges, especially when the samples have different library sizes and the data are overdispersed with many zeros. To address these challenges, we introduce a new statistical framework, called predictive analysis in metagenomics via inverse regression (PAMIR), to analyze microbiome sequencing data. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13061
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http://dx.doi.org/10.1111/biom.13061DOI Listing
April 2019
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A Framework Proposal To Follow-Up On Preclinical Convulsive Signals of A New Molecular Entity In First-In-Human Studies Using EEG Monitoring.

Clin Pharmacol Ther 2019 Apr 16. Epub 2019 Apr 16.

Department of Safety & Risk Management, F. Hoffmann-La Roche AG, Basel, Switzerland.

Traditionally, in dose escalating first-in-human studies, a dose cap with a 10-fold safety margin to the no-observed- effect-level in animals is implemented if convulsive events were observed in animals. However, the convulsive risk seen in animals does not generally translate into humans. Several lines of evidence are summarized indicating that in a dose escalating setting electroencephalographic epileptiform abnormalities occur at lower doses than clinical convulsive events. Read More

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http://dx.doi.org/10.1002/cpt.1455DOI Listing

The effect of silencing immunity related genes on longevity in a naturally occurring Anopheles arabiensis mosquito population from southwest Ethiopia.

Parasit Vectors 2019 Apr 16;12(1):174. Epub 2019 Apr 16.

Department of Life Sciences, Imperial College London, London, UK.

Background: Vector control remains the most important tool to prevent malaria transmission. However, it is now severely constrained by the appearance of physiological and behavioral insecticide resistance. Therefore, the development of new vector control tools is warranted. Read More

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http://dx.doi.org/10.1186/s13071-019-3414-yDOI Listing

Effect of a Workplace Wellness Program on Employee Health and Economic Outcomes: A Randomized Clinical Trial.

JAMA 2019 04;321(15):1491-1501

University of Chicago Harris School of Public Policy, Chicago, Illinois.

Importance: Employers have increasingly invested in workplace wellness programs to improve employee health and decrease health care costs. However, there is little experimental evidence on the effects of these programs.

Objective: To evaluate a multicomponent workplace wellness program resembling programs offered by US employers. Read More

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http://dx.doi.org/10.1001/jama.2019.3307DOI Listing

Phantom testing of the sensitivity and precision of a sub-epidermal moisture scanner.

Int Wound J 2019 Apr 16. Epub 2019 Apr 16.

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.

The majority of pressure ulcers (PUs) including deep tissue injuries (DTIs) are preventable, and even reversible if detected in their early phase. One of the greatest barriers in PU prevention is that clinicians traditionally depended on subjective and qualitative techniques, particularly routine visual skin assessments that would only document existing, macroscopic PUs/DTIs, rather than preventing them or detecting them at their microscopic phase. At the early phase of cell damage, when a forming PU is still microscopic, there is a local increase in extracellular fluid contents within affected tissues, which is called sub-epidermal moisture (SEM). Read More

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http://dx.doi.org/10.1111/iwj.13132DOI Listing

Reduction of cervical cancer incidence within a primary HPV screening pilot project (WOLPHSCREEN) in Wolfsburg, Germany.

Br J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Klinikum Wolfsburg, Wolfsburg, Germany.

Background: Randomised controlled trials showed human papillomavirus (HPV)-based screening leads to a significant reduction in cervical cancer incidence compared with cytology-based screening only.

Methods: Non-hysterectomised participants ≥30 years underwent co-testing with Papanicolaou (Pap) smear and HR-HPV testing (Hybrid Capture 2; HC2). Women with normal findings had their next screening round after 5 years, and HC2+ and Pap abnormal cases were immediately referred for colposcopy, while cases with discordant findings had repeat testing after 12 months with referral to colposcopy in cases with persistent positive findings. Read More

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http://www.nature.com/articles/s41416-019-0453-2
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http://dx.doi.org/10.1038/s41416-019-0453-2DOI Listing
April 2019
1 Read

Double-wavelet transform for multisubject task-induced functional magnetic resonance imaging data.

Biometrics 2019 Apr 15. Epub 2019 Apr 15.

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.

The goal of this article is to model multisubject task-induced functional magnetic resonance imaging (fMRI) response among predefined regions of interest (ROIs) of the human brain. Conventional approaches to fMRI analysis only take into account temporal correlations, but do not rigorously model the underlying spatial correlation due to the complexity of estimating and inverting the high dimensional spatio-temporal covariance matrix. Other spatio-temporal model approaches estimate the covariance matrix with the assumption of stationary time series, which is not always feasible. Read More

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http://dx.doi.org/10.1111/biom.13055DOI Listing

Confidence bands for multiplicative hazards models: Flexible resampling approaches.

Biometrics 2019 Apr 15. Epub 2019 Apr 15.

Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

We propose new resampling-based approaches to construct asymptotically valid time-simultaneous confidence bands for cumulative hazard functions in multistate Cox models. In particular, we exemplify the methodology in detail for the simple Cox model with time-dependent covariates, where the data may be subject to independent right-censoring or left-truncation. We use simulations to investigate their finite sample behavior. Read More

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http://dx.doi.org/10.1111/biom.13059DOI Listing

Trends in incidence of diabetes in Jordan between 1994 and 2017.

Diabet Med 2019 Apr 15. Epub 2019 Apr 15.

Institute for Biometrics and Epidemiology, German Diabetes Centre (DDZ), Leibniz Centre for Diabetes Research at Heinrich Heine University, Düsseldorf.

Ajlouni et al. [1] provided valuable results on time trends in diabetes prevalence in Jordan. Their study covered the years 1994 to 2017 with consistent methods used for measuring prevalence throughout the study period. Read More

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http://dx.doi.org/10.1111/dme.13966DOI Listing

Persistent Metabolic Acidosis on Regular Hemodialysis or Peritoneal Dialysis.

Indian J Nephrol 2019 Mar-Apr;29(2):84-89

Department of Nephrology, JIPMER, Puducherry, India.

Metabolic acidosis is known to have adverse consequences in patients with chronic kidney disease (CKD) including protein-energy wasting, inflammation, bone disease, and disturbance in endocrine function. Unlike in the management of patients with predialysis CKD, bicarbonate levels were not being routinely monitored in dialysis patients at our center. The KDOQI guidelines recommend serum bicarbonate levels ≥22 mEq/L in patients on dialysis. Read More

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http://dx.doi.org/10.4103/ijn.IJN_309_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440337PMC
April 2019
1 Read

Disease Modification in Alzheimer's Disease: Current Thinking.

Ther Innov Regul Sci 2019 Apr 14:2168479019841894. Epub 2019 Apr 14.

7 Biostatistics and Research Decision Sciences, Merck Research Laboratories (MRL), Merck & Co, Inc, Kenilworth, NJ, USA.

Alzheimer's disease (AD) has increasingly been recognized as a huge unmet medical need. Currently, there is no approved drug to cure, prevent, or even slow down the disease. It is imperative to develop disease-modifying treatments for AD to alter the underlying disease progression. Read More

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http://dx.doi.org/10.1177/2168479019841894DOI Listing

Patient-Sharing Relations in the Treatment of Diabetes and Their Implications for Health Information Exchange: Claims-Based Analysis.

JMIR Med Inform 2019 Apr 12;7(2):e12172. Epub 2019 Apr 12.

Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

Background: Health information exchange (HIE) among care providers who cooperate in the treatment of patients with diabetes mellitus (DM) has been rated as an important aspect of successful care. Patient-sharing relations among care providers permit inferences about corresponding information-sharing relations.

Objectives: This study aimed to obtain information for an effective HIE platform design to be used in DM care by analyzing patient-sharing relations among various types of care providers (ToCPs), such as hospitals, pharmacies, and different outpatient specialists, within a nationwide claims dataset of Austrian DM patients. Read More

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http://medinform.jmir.org/2019/2/e12172/
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http://dx.doi.org/10.2196/12172DOI Listing
April 2019
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Are corticosteroid injections needed after needling and lavage of calcific tendinitis? Randomised, double-blind, non-inferiority trial.

Ann Rheum Dis 2019 Apr 11. Epub 2019 Apr 11.

Department of Rheumatology, CHU Nantes, Nantes, France

Objective: Steroid injections are common after an ultrasound-guided puncture and lavage (UGPL) of calcific tendonitis of the rotator cuff. However, steroids may prevent calcification resorption and negatively affect tendon healing. Our study was designed to determine whether saline solution was non-inferior to steroids in the prevention of acute pain reactions in the week following UGPL. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214971DOI Listing
April 2019
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Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes.

Sci Rep 2019 Apr 10;9(1):5864. Epub 2019 Apr 10.

Laboratory of Molecular Pathology, Department of Pathological Sciences, State University of Londrina, UEL, Londrina, PR, Brazil.

Metformin was shown to sensitize multidrug resistant breast cancer cells; however, the mechanisms involved in this capacity need to be clarified. We investigated oxidative stress and inflammatory-related pathways during the induction of doxorubicin resistance in MCF-7 and MDA-MB-231 human breast cancer cells (DOX-res group), and evaluated metformin-induced cellular responses that resulted in the prevention of doxorubicin resistance (Met-DOX group). Microarray analysis demonstrated that DOX-res changed the expression of genes involved in oxidative stress (OS) and the TGF- β1 pathway. Read More

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http://dx.doi.org/10.1038/s41598-019-42357-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458149PMC
April 2019
3 Reads

An Equation Based on Fuzzy Mathematics to Assess the Timing of Haemodialysis Initiation.

Sci Rep 2019 Apr 10;9(1):5871. Epub 2019 Apr 10.

Dalian Medical University Graduate School, Dalian, China.

In order to develop an equation that integrates multiple clinical factors including signs and symptoms associated with uraemia to assess the initiation of dialysis, we conducted a retrospective cohort study including 25 haemodialysis centres in Mainland China. Patients with ESRD (n = 1281) who commenced haemodialysis from 2008 to 2011 were enrolled in the development cohort, whereas 504 patients who began haemodialysis between 2012 and 2013 were enrolled in the validation cohort comprised. An artificial neural network model was used to select variables, and a fuzzy neural network model was then constructed using factors affecting haemodialysis initiation as input variables and 3-year survival as the output variable. Read More

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http://www.nature.com/articles/s41598-018-37762-6
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http://dx.doi.org/10.1038/s41598-018-37762-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458145PMC
April 2019
6 Reads
5.078 Impact Factor

Psychometric Validation of the Autism Impact Measure (AIM).

J Autism Dev Disord 2019 Apr 9. Epub 2019 Apr 9.

Patient Centered Outcomes Research, Biometrics, Roche Products, Ltd, Falcon Way, Welwyn Garden City, UK.

The Autism impact measure (AIM) is a caregiver-reported questionnaire assessing autism symptom frequency and impact in children, previously shown to have good test-retest reliability, convergent validity and structural validity. This study extended previous work by exploring the AIM's ability to discriminate between 'known-groups' of children, and estimating thresholds for clinically important responses. Data were collected online and electronically on computer and mobile devices; hence, it was also possible to confirm other psychometric properties of the AIM in this format. Read More

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http://link.springer.com/10.1007/s10803-019-04011-2
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http://dx.doi.org/10.1007/s10803-019-04011-2DOI Listing
April 2019
1 Read

Is Achieving High Flexion Necessary for Satisfaction after Total Knee Arthroplasty in Indian Patients?

Indian J Orthop 2019 Mar-Apr;53(2):270-275

Senior Director and Head -Biometrics and Data Management Synchron Research Services Pvt. Ltd. Ahmedabad, Gujarat, India.

Background: Total knee arthroplasty (TKA) is a very successful operation for the treatment of end-stage arthritis of the knee joint. In spite of improvement in surgical technique, implant design, postoperative pain management, and rehabilitation, some patients are not satisfied with the outcome of the surgery. It is believed that high-flexion (H-F) activities such as cross-legged sitting and squatting are necessary for satisfaction after TKA in Indian patients due to cultural and social reasons. Read More

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http://dx.doi.org/10.4103/ortho.IJOrtho_268_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415565PMC
April 2019
1 Read

Robust Face Recognition Based on a New Supervised Kernel Subspace Learning Method.

Sensors (Basel) 2019 Apr 6;19(7). Epub 2019 Apr 6.

Department of Mechanical Engineering, University of Málaga, Doctor Ortiz Ramos s/n, 29071 Malaga, Spain.

Face recognition is one of the most popular techniques to achieve the goal of figuring out the identity of a person. This study has been conducted to develop a new non-linear subspace learning method named "supervised kernel locality-based discriminant neighborhood embedding," which performs data classification by learning an optimum embedded subspace from a principal high dimensional space. In this approach, not only nonlinear and complex variation of face images is effectively represented using nonlinear kernel mapping, but local structure information of data from the same class and discriminant information from distinct classes are also simultaneously preserved to further improve final classification performance. Read More

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http://dx.doi.org/10.3390/s19071643DOI Listing

Rejoinder to Discussions on: Model confidence bounds for variable selection.

Biometrics 2019 Apr 6. Epub 2019 Apr 6.

Department of Operations, Business Analytics, and Information Systems, University of Cincinnati.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13020
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http://dx.doi.org/10.1111/biom.13020DOI Listing
April 2019
3 Reads

Fetal ocular development in the second trimester of pregnancy documented by 7.0 T postmortem Magnetic Resonance Imaging.

PLoS One 2019 4;14(4):e0214939. Epub 2019 Apr 4.

Department of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.

Few investigators have analyzed fetal ocular growth with Magnetic Resonance Imaging (MRI) of high magnetic strength. Our purpose is to obtain normative biometrics for fetal ocular development in the second trimester of pregnancy. Sixty specimens with a gestational age (GA) of 12-23 weeks were scanned using a 7. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214939PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448861PMC
April 2019
3 Reads

Discussion on "Model Confidence Bounds for Variable Selection" by Yang Li, Yuetian Luo, Davide Ferrari, Xiaonan Hu, and Yichen Qin.

Biometrics 2019 Apr 3. Epub 2019 Apr 3.

Departments of Mathematics and Computer Science, Université libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1111/biom.13022DOI Listing

Discussion of "A hybrid phase I-II/III clinical trial design allowing dose re-optimization in phase III" by Andrew G. Chapple and Peter F. Thall.

Biometrics 2019 Apr 3. Epub 2019 Apr 3.

Research Institute, NorthShore University HealthSystem, Evanston, Illinois.

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http://dx.doi.org/10.1111/biom.12992DOI Listing

Discussion of "A Hybrid Phase I-II/III Clinical Trial Design Allowing Dose Re-Optimization in Phase III" by Andrew G. Chapple and Peter F. Thall.

Biometrics 2019 Apr 3. Epub 2019 Apr 3.

Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1111/biom.12993DOI Listing

A Multidimensional Approach to Assessing Anthropometric and Aerobic Fitness Profiles of Elite Brazilian Endurance Athletes and Military Personnel.

Mil Med 2019 Apr 3. Epub 2019 Apr 3.

Biometrics Laboratory, School of Physical Education and Sports, Federal University of Rio de Janeiro. 540 Carlos Chagas Filho Avenue, Rio de Janeiro, RJ, Brazil.

Introduction: Military personnel must remain physically active to meet operational requirements. Military physical training not only provides the performance capabilities required for performing occupational tasks but also fosters the development of sport. Thus, Armed Forces across the world have historically invested in developing elite- and Olympic-level athletes. Read More

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http://dx.doi.org/10.1093/milmed/usz003DOI Listing

MicroRNA-496 and Mechanistic Target of Rapamycin Expression are Associated with Type 2 Diabetes Mellitus and Obesity in Elderly People.

Ann Nutr Metab 2019 Apr 2;74(4):279-286. Epub 2019 Apr 2.

Department of General, Visceral, Vascular, and Pediatric Surgery, University of Saarland Medical Center, Homburg, Germany.

Background: Mechanistic target of rapamycin (mTOR) regulates lipid and glucose metabolism thus playing a key role in metabolic diseases like type 2 diabetes mellitus (T2DM). Recently, we demonstrated a functional interaction of microRNA-496 (miR-496) with mTOR and its impact on the regulation of human ageing.

Objectives: As T2DM is most prevalent in older adults, we hypothesized that miR-496 may also have an impact on mTOR regulation in T2DM. Read More

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http://dx.doi.org/10.1159/000499576DOI Listing
April 2019
2 Reads

The evolving landscape of human papillomavirus-related oropharyngeal squamous cell carcinoma at a single institution in Northern Italy.

Acta Otorhinolaryngol Ital 2019 Feb;39(1):9-17

Department of Otolaryngology, University of Pavia and Foundation IRCCS Policlinico S. Matteo, Italy.

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http://dx.doi.org/10.14639/0392-100X-1905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444161PMC
February 2019
1 Read

Changes in sleep and airway variables in patients with obstructive sleep apnea after mandibular advancement splint treatment.

Am J Orthod Dentofacial Orthop 2019 Apr;155(4):498-508

Department of Orthodontics, College of Dentistry, University of Illinois, Chicago, Ill. Electronic address:

Introduction: Obstructive sleep apnea (OSA) is an extensive public health problem that imposes considerable morbidity. Mandibular advancement splint (MAS) therapy is a well tolerated treatment, but success rates are difficult to predict. Our objective was to investigate the relationship of oropharyngeal airway dimensions, sleep characteristics, patient biometrics, and treatment response within an OSA patient sample. Read More

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http://dx.doi.org/10.1016/j.ajodo.2018.05.022DOI Listing
April 2019
4 Reads

Selection of prosthetic aortic valves in the United States among elderly Medicare patients from 2006 to 2015.

J Thorac Cardiovasc Surg 2019 Feb 26. Epub 2019 Feb 26.

Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Md.

Background: Both biological and mechanical prosthetic valves are treatment choices for aortic valve replacement. We aimed to characterize the selection of prosthetic aortic valves among elderly Medicare patients.

Methods: This was a retrospective analysis of patients aged 65 years or older who underwent aortic valve replacement alone or in combination with other procedures in the 2006-2015 Medicare databases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225223193044
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http://dx.doi.org/10.1016/j.jtcvs.2019.02.012DOI Listing
February 2019
2 Reads

Potentially toxic elements in commonly consumed fish species from the western Mediterranean Sea (Almería Bay): Bioaccumulation in liver and muscle tissues in relation to biometric parameters.

Sci Total Environ 2019 Mar 23;671:280-287. Epub 2019 Mar 23.

Dept. Environment, National Institute of Agricultural and Food Research and Technology (I.N.I.A), Ctra. de A Coruña 7.5, 28040 Madrid, Spain. Electronic address:

Marine pollution is one of today's most relevant problems. Public awareness has been raised about the harmful potential of heavy metals (HMs) accumulating in edible fish and possibly ending up in human diet through the food chain. This study aimed to characterize and evaluate As, Cd, Cr, Cu, Ni and Pb contents in four edible fish species from the western Mediterranean Sea. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.359DOI Listing
March 2019
1 Read

Ventilatory pattern variability as a biometric for severity of acute lung injury in rats.

Respir Physiol Neurobiol 2019 Mar 27. Epub 2019 Mar 27.

Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Louis Stokes VA Medical Center, Cleveland, OH 44106, USA.

We hypothesize that ventilatory pattern variability (VPV) varies with the magnitude of acute lung injury (ALI). In adult male rats, we instilled a low- or high- dose of bleomycin or saline (PBS) intratracheally. While representative samples of pulmonary tissue indicated graded lung injury, coefficient of variation (CV) of TTOT did not differ among the 3 groups. Read More

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http://dx.doi.org/10.1016/j.resp.2019.03.009DOI Listing
March 2019
3 Reads

Dilation after laryngectomy: Incidence, risk factors and complications.

Oral Oncol 2019 Apr 6;91:107-112. Epub 2019 Mar 6.

Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.

Background: Neopharyngeal stenosis is a recognized sequela of total laryngectomy (TL). We aim to investigate the incidence of stenosis requiring dilation, risk factors for stenosis and complications of dilation.

Methods: Retrospective cohort study of patients undergoing TL in two dedicated head and neck centers in the Netherlands. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.025DOI Listing
April 2019
1 Read
3.607 Impact Factor

Tiotropium is efficacious in 6-17-year-olds with asthma, independent of T2 phenotype.

J Allergy Clin Immunol Pract 2019 Mar 25. Epub 2019 Mar 25.

Children's Center Bethel, Evangelisches Klinikum Bethel, Bielefeld, and Allergy Center of the Ruhr University, Bochum, Germany.

Background: Tiotropium add-on therapy has demonstrated efficacy and safety in 6-17-year-olds with symptomatic asthma despite treatment with inhaled corticosteroids (ICS), with or without additional controllers. Pediatric patients often have a significant allergic component to their asthma.

Objective: To explore whether responses to tiotropium add-on were influenced by patients' type 2 (T2) status, assessed by serum immunoglobulin E (IgE) levels and blood eosinophil counts. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.03.019DOI Listing

Cell-free DNA in the supernatant of pleural effusion can be used to detect driver and resistance mutations, and can guide tyrosine kinase inhibitor treatment decisions.

ERJ Open Res 2019 Feb 25;5(1). Epub 2019 Mar 25.

Dept of Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Objectives: Molecular profiling of tumours has become the mainstay of diagnostics for metastasised solid malignancies and guides personalised treatment, especially in nonsmall cell lung cancer (NSCLC). In current practice, it is often challenging to obtain sufficient tumour material for reliable molecular analysis. Cell-free DNA (cfDNA) in blood or other bio-sources could present an alternative approach to obtain genetic information from the tumour. Read More

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http://dx.doi.org/10.1183/23120541.00016-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431750PMC
February 2019
1 Read

Likelihood-Ratio-Test Methods for Drug Safety Signal Detection from Multiple Clinical Datasets.

Comput Math Methods Med 2019 19;2019:1526290. Epub 2019 Feb 19.

Division Director in the Division of Biostatistics, Office of Clinical Evidence and Analysis, CDRH, FDA, Silver Spring, MD 20993, USA.

Pre- and postmarket drug safety evaluations usually include an integrated summary of results obtained using data from multiple studies related to a drug of interest. This paper proposes three approaches based on the likelihood ratio test (LRT), called the LRT methods, for drug safety signal detection from large observational databases with multiple studies, with focus on identifying signals of adverse events (AEs) from many AEs associated with a particular drug or inversely for signals of drugs associated with a particular AE. The methods discussed include simple pooled LRT method and its variations such as the weighted LRT that incorporates the total drug exposure information by study. Read More

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http://dx.doi.org/10.1155/2019/1526290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399568PMC
February 2019

Evaluation of in-vehicle technologies to prevent unlicensed driving in Queensland and Victoria.

Accid Anal Prev 2019 Jun 21;127:210-222. Epub 2019 Mar 21.

Queensland University of Technology (QUT), CARRS-Q, GPO Box 2434, Brisbane, QLD 4001, Australia.

Unlicensed driving is a serious problem in many Australian states, with unlicensed driving-related crashes (UDC) costing up to $304 million per year in Queensland, and $176 million in Victoria. In this paper, we present a Benefit-Cost Ratio (BCR) analysis of a set of Intelligent Transportation Systems technologies aimed at preventing unlicensed driving by verifying the driver's identity through biometric technology, as well as the validity of their licence. Utilised together, the technology would essentially take the form of a licence interlock. Read More

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http://dx.doi.org/10.1016/j.aap.2019.02.023DOI Listing

Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug Induced Liver Toxicity.

Toxicol Sci 2019 Mar 23. Epub 2019 Mar 23.

Safety Assessment and Laboratory Animal Resources MRL, Kenilworth, NJ, USA.

Inhibition of the Bile Salt Export Pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical animal models. Here we present the development of a novel rat model using siRNA knockdown (KD) of Bsep that displayed differentially enhanced hepatotoxicity to 8 Bsep inhibitors and not to 3 Bsep non-inhibitors when administered at maximally tolerated doses for 7 days. Bsep KD alone resulted in 3- and 4. Read More

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http://dx.doi.org/10.1093/toxsci/kfz079DOI Listing
March 2019
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Human identification using a new matching Pursuit-based feature set of ECG.

Comput Methods Programs Biomed 2019 Apr 13;172:87-94. Epub 2019 Feb 13.

Graduated from Department of Biomedical Engineering, Faculty of Electrical Engineering, Sahand University of Technology, Tabriz, Iran. Electronic address:

Background And Objective: In recent years, many attempts have been made to design reliable systems for identifying individuals using biometrics. Electrocardiogram (ECG) biometric is one of the newest methods that not only offers unique characteristics of individuals for human identification, but also the possibility of counterfeiting it is negligible. In this paper, our objective was to develop an identification system using a non-fiducial one-lead ECG feature set based on a sparse algorithm. Read More

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http://dx.doi.org/10.1016/j.cmpb.2019.02.009DOI Listing

Evaluation of Earbud and Wristwatch Heart Rate Monitors during Aerobic and Resistance Training.

Int J Exerc Sci 2019 1;12(4):374-384. Epub 2019 Mar 1.

Department of Kinesiology and Physical Education, Valdosta State University, Valdosta, GA, USA.

Assessment of biometrics during exercise is evolving to create devices that are "all-inclusive", in an effort to decrease the number of devices required during exercise while providing comprehensive and accurate biometric measures. The purpose of this study was to determine the accuracy of two optical heart rate monitors, the Jabra earbud and the Mio Alpha wristwatch, during aerobic and anaerobic exercise. Twenty-two recreationally active participants (25. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413847PMC

A Novel Technique for Multi Biometric Cryptosystem Using Fuzzy Vault.

Authors:
V Sujitha D Chitra

J Med Syst 2019 Mar 21;43(5):112. Epub 2019 Mar 21.

Department of CSE, P. A. College of Engineering and Technology, Pollachi, Tamilnadu, India.

Biometric authentication is the process of recognizing a person by means of his\her psychological or behavioral traits. One of the most important issues faced by the biometric system developer is to protect the template obtained from the biometric of a person. Unimodal biometric system has some drawbacks such as noisy data, interclass variations and spoof attack. Read More

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http://dx.doi.org/10.1007/s10916-019-1220-xDOI Listing

Pilot-Testing of "Healthy Body Healthy Mind": An Integrative Lifestyle Program for Patients With a Mental Illness and Co-morbid Metabolic Syndrome.

Front Psychiatry 2019 6;10:91. Epub 2019 Mar 6.

Professorial Unit, The Melbourne Clinic, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.

Metabolic syndrome and co-morbid physical health conditions are highly prevalent in people with a mental illness. Modifiable lifestyle factors have been targeted to improve health outcomes. Healthy Body Healthy Mind (HBHM) program was developed to provide an integrated evidence-based program incorporating practical diet and exercise instruction; alongside meditation and mindfulness strategies, and comprehensive psychoeducation, to improve the physical and mental health of those with a mental illness. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414430PMC
March 2019
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Genetic divergence of native palms of Oenocarpus distichus considering biometric fruit variables.

Sci Rep 2019 Mar 20;9(1):4943. Epub 2019 Mar 20.

Departamento de Entomologia/BIOAGRO, Universidade Federal de Viçosa, 36570-900, Viçosa, Minas Gerais, Brazil.

Oenocarpus distichus presents economic, ecological, and dietary potential for pulp market processed in natura. Germplasm conservation and genetic improvement depend on genetic divergence studies. The objective was to quantify genetic divergence in a native population of O. Read More

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http://dx.doi.org/10.1038/s41598-019-41507-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427014PMC

Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults.

Br J Ophthalmol 2019 Mar 20. Epub 2019 Mar 20.

Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, USA

Background: Glaucoma prevalence and subtype profile vary across different racial and ethnic groups. This study provides a comparative evaluation of differences in aqueous humour dynamics (AHD) and ocular biometrics in healthy Chinese and Caucasian adults of two different age groups.

Methods: Data from two independent studies with identical designs were compared. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313132DOI Listing

Serum uromodulin is associated with but does not predict type 2 diabetes in elderly KORA F4/FF4 study participants.

J Clin Endocrinol Metab 2019 Mar 20. Epub 2019 Mar 20.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany.

Aims: Serum uromodulin has recently emerged as promising biomarker for kidney function and was suggested to be associated with type 2 diabetes (T2D) in coronary patients. Here, we analyzed the association of serum uromodulin with T2D in the population-based KORA F4/FF4 study.

Methods: In 1119 participants of the KORA F4 study aged 62 - 81 years, serum uromodulin was measured and the association of serum uromodulin with T2D was assessed using logistic and linear regression models stratified for sex. Read More

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http://dx.doi.org/10.1210/jc.2018-02557DOI Listing
March 2019
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Subjective cognitive decline, ε4, and incident mild cognitive impairment in men and women.

Alzheimers Dement (Amst) 2019 Dec 6;11:221-230. Epub 2019 Mar 6.

Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Introduction: Possible joint effects of subjective cognitive decline (SCD) and apolipoprotein E () ε4 genotype on incident mild cognitive impairment (MCI) were examined for men and women separately.

Methods: Cognitively normal participants with and without SCD were included from the first follow-up examination of the population-based Heinz Nixdorf Recall study. Sex-stratified logistic regression models estimated main effects and interactions (additive, multiplicative) of SCD at the first follow-up (yes+/no-) and ε4 (positive+/negative-) groups for MCI 5 years later. Read More

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http://dx.doi.org/10.1016/j.dadm.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404645PMC
December 2019
1 Read