10,707 results match your criteria Biometrics & biostatistics international journal[Journal]


Evaluating Biochemically Recurrent Prostate Cancer: Histologic Validation of F-DCFPyL PET/CT with Comparison to Multiparametric MRI.

Radiology 2020 Jul 7:192018. Epub 2020 Jul 7.

From the Molecular Imaging Program, National Cancer Institute, Building 10, Room B3B47A, Bethesda, MD 20892 (L.L., E.M., B.T., I.L., F.L., A.T., Y.L.M., P.E., P.L.C.); Division of Cancer Treatment and Diagnosis: Biometric Research Program, National Cancer Institute, National Institutes of Health, Bethesda, Md (J.H.S.); National Cancer Institute Biometrics Research Program Contract, General Dynamics Information Technology, Falls Church, Va (S.E.R.); Clinical Research Directorate, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Bethesda, Md (S.A.H.); Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md (D.E.C.); Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md (W.D., R.M.); Center of Interventional Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Md (B.J.W., V.K., R.C., E.L.); Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md (P.P.); and Cancer Imaging Program, National Cancer Institute, Bethesda, Md (J.F.E.).

Background Prostate cancer recurrence is found in up to 40% of men with prior definitive (total prostatectomy or whole-prostate radiation) treatment. Prostate-specific membrane antigen PET agents such as 2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (F-DCFPyL) may improve detection of recurrence compared with multiparametric MRI; however, histopathologic validation is lacking. Purpose To determine the sensitivity, specificity, and positive predictive value (PPV) of F-DCFPyL PET/CT based on histologic analysis and to compare with pelvic multiparametric MRI in men with biochemically recurrent prostate cancer. Read More

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http://dx.doi.org/10.1148/radiol.2020192018DOI Listing

Fatigue in adults with spinal muscular atrophy under treatment with nusinersen.

Sci Rep 2020 Jul 6;10(1):11069. Epub 2020 Jul 6.

Department of Neurology, University Hospital Essen, Essen, Germany.

5q-Associated spinal muscular atrophy is a hereditary neuromuscular disease leading to progressive muscle weakness in which fatigue occurs and affects quality of life. Treatment with the antisense oligonucleotide nusinersen has been shown to improve motor function. Fatigue can be measured within the Fatigue Severity Scale (FSS). Read More

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http://dx.doi.org/10.1038/s41598-020-68051-wDOI Listing

Markers of potassium homeostasis in salt losing tubulopathies- associations with hyperaldosteronism and hypomagnesemia.

BMC Nephrol 2020 Jul 6;21(1):256. Epub 2020 Jul 6.

Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria.

Background: Renal loss of potassium (K) and magnesium (Mg) in salt losing tubulopathies (SLT) leads to significantly reduced Quality of Life (QoL) and higher risks of cardiac arrhythmia. The normalization of K is currently the most widely accepted treatment target, however in even excellently designed RCTs the increase of K was only mild and rarely normalized. These findings question the role of K as the ideal marker of potassium homeostasis in SLT. Read More

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http://dx.doi.org/10.1186/s12882-020-01905-7DOI Listing

Genetic Diversity, Population Structure, and Parentage Analysis of Croatian Grapevine Germplasm.

Genes (Basel) 2020 Jul 2;11(7). Epub 2020 Jul 2.

Department of Plant Breeding, Genetics and Biometrics, Faculty of Agriculture, University of Zagreb, Svetošimunska 25, 10000 Zagreb, Croatia.

Croatian viticulture was most extensive at the beginning of the 20th century, when about 400 varieties were in use. Autochthonous varieties are the result of spontaneous hybridization from the pre-phylloxera era and are still cultivated today on about 35 % of vineyard area, while some exist only in repositories. We present what is the most comprehensive genetic analysis of all major Croatian national repositories, with a large number of microsatellite, or simple sequence repeat (SSR) markers, and it is also the first study to apply single nucleotide polymorphism (SNP) markers. Read More

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http://dx.doi.org/10.3390/genes11070737DOI Listing

A bayesian hierarchical model for characterizing the diffusion of new antipsychotic drugs.

Biometrics 2020 Jul 6. Epub 2020 Jul 6.

Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA, 02115, USA.

New prescription medications are a primary driver of spending growth in the United States. For patients with severe mental illnesses, second generation antipsychotic (SGA) medications feature prominently. However, many SGAs are costly, particularly before generic entry, and some may increase the risk of diabetes. Read More

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http://dx.doi.org/10.1111/biom.13324DOI Listing

Estimation of incubation period and generation time based on observed length-biased epidemic cohort with censoring for COVID-19 outbreak in China.

Biometrics 2020 Jul 6. Epub 2020 Jul 6.

Beijing International Center for Mathematical Research, Peking University, Beijing, 100871, China.

The incubation period and generation time are key characteristics in the analysis of infectious diseases. The commonly used contact-tracing based estimation of incubation distribution is highly influenced by the individuals' judgment on the possible date of exposure, and might lead to significant errors. On the other hand, interval censoring based methods are able to utilize a much larger set of traveling data but may encounter biased sampling problems. Read More

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http://dx.doi.org/10.1111/biom.13325DOI Listing

Semiparametric estimation of cross-covariance functions for multivariate random fields.

Biometrics 2020 Jul 6. Epub 2020 Jul 6.

Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.

The prevalence of spatially referenced multivariate data has impelled researchers to develop procedures for joint modeling of multiple spatial processes. This ordinarily involves modeling marginal and cross-process dependence for any arbitrary pair of locations using a multivariate spatial covariance function. However, building a flexible multivariate spatial covariance function that is nonnegative definite is challenging. Read More

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http://dx.doi.org/10.1111/biom.13323DOI Listing

Structural factor equation models for causal network construction via directed acyclic mixed graphs.

Biometrics 2020 Jul 6. Epub 2020 Jul 6.

Department of Biostatistics, University of Michigan, Ann Arbor, MI.

Directed acyclic mixed graphs (DAMG) provide a useful representation of network topology with both directed and undirected edges subject to the restriction of no directed cycles in the graph. This graphical framework may arise in many biomedical studies, for example when a directed acyclic graph (DAG) of interest is contaminated with undirected edges induced by some unobserved confounding factors (e.g. Read More

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http://dx.doi.org/10.1111/biom.13322DOI Listing

Long-term antithrombotic management patterns in Asian patients with acute coronary syndrome: 2-year observations from the EPICOR Asia study.

Clin Cardiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiology, Sarawak General Hospital, Kuching, Malaysia.

Background: Despite guideline recommendations, dual antiplatelet therapy (DAPT) is frequently used for longer than 1 year after an acute coronary syndrome (ACS) event. In Asia, information on antithrombotic management patterns (AMPs), including DAPT post discharge, is sparse. This analysis evaluated real-world AMPs up to 2 years post discharge for ACS. Read More

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http://dx.doi.org/10.1002/clc.23400DOI Listing

Development of a High-Density Piezoelectric Micromachined Ultrasonic Transducer Array Based on Patterned Aluminum Nitride Thin Film.

Micromachines (Basel) 2020 Jun 26;11(6). Epub 2020 Jun 26.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, Korea.

This study presents the fabrication and characterization of a piezoelectric micromachined ultrasonic transducer (pMUT; radius: 40 µm) using a patterned aluminum nitride (AlN) thin film as the active piezoelectric material. A 20 × 20 array of pMUTs using a 1 µm thick AlN thin film was designed and fabricated on a 2 × 2 mm footprint for a high fill factor. Based on the electrical impedance and phase of the pMUT array, the electromechanical coefficient was ~1. Read More

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http://dx.doi.org/10.3390/mi11060623DOI Listing

Meta-analysis of blinded and unblinded studies for ongoing aggregate safety monitoring and evaluation.

Contemp Clin Trials 2020 Jun 27:106068. Epub 2020 Jun 27.

Clinical Safety Statistics, Merck & Co., Inc., Rahway, NJ, USA.

During the course of clinical development, ongoing aggregate safety monitoring and evaluation are needed to understand the evolving safety profile and to ensure effective risk-management strategies for medicinal products. CIOMS reports and global regulatory guidance (including from ICH, US FDA, and EMA) compel sponsors for assessment of safety based on aggregate data. To identify and characterize the risks of medicinal products at a program level in a more timely and informed manner, aggregate safety evaluations should combine all available information, including from ongoing blinded trials, completed unblinded trials, and other data sources. Read More

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http://dx.doi.org/10.1016/j.cct.2020.106068DOI Listing

Benefit-Risk Profile of DAPT Continuation Beyond 1 Year after PCI in Patients with High Thrombotic Risk Features as Endorsed by 2018 ESC/EACTS Myocardial Revascularization Guideline.

Cardiovasc Drugs Ther 2020 Jun 29. Epub 2020 Jun 29.

Department of Cardiology, Coronary Heart Disease Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Purpose: The ischemic/bleeding trade-off of continuing dual antiplatelet therapy (DAPT) beyond 1 year after PCI for patients with high thrombotic risk (HTR) as endorsed by 2018 ESC/EACTS myocardial revascularization guidelines remain unknown.

Methods: Patients undergoing coronary stenting between January 2013 and December 2013 from the prospective Fuwai registry were defined as HTR if they met at least 1 ESC/EACTS guideline-endorsed HTR criteria. A total of 4578 patients who were at HTR and were events free at 1 year after the index procedure were evaluated. Read More

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http://dx.doi.org/10.1007/s10557-020-07030-9DOI Listing
June 2020
3.189 Impact Factor

Age dependency of the diabetes effects on the iris recognition systems performance evaluation results.

Biomed Tech (Berl) 2020 Jun 29. Epub 2020 Jun 29.

Biometrics and Machine Intelligence, NASK, Kolska 12, 01-045 Warsaw, Poland.

In this paper, we attempt to answer the questions whether iris recognition task under the influence of diabetes would be more difficult and whether the effects of diabetes and individuals' age are uncorrelated. We hypothesized that the health condition of volunteers plays an important role in the performance of the iris recognition system. To confirm the obtained results, we reported the distribution of usable area in each subgroup to have a more comprehensive analysis of diabetes effects. Read More

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http://dx.doi.org/10.1515/bmt-2019-0246DOI Listing

Relationship between executive functions and academic performance among Moroccan middle school students.

Dement Neuropsychol 2020 Apr-Jun;14(2):194-199

Cognitive Behavioral Neuroscience and Applied Nutrition Team, Faculty of Sciences, University of Ibn Tofail, Kenitra, Morocco.

Executive functions (EF) play a central role in the development of social and cognitive skills and academic learning.

Objective: For this reason, this study aims to determine the relationship between executive functions and academic performance among middle school students in the Middle Atlas of Morocco.

Methods: This study focuses on 137 middle school students studying at four colleges located in the Middle Atlas of Morocco. Read More

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http://dx.doi.org/10.1590/1980-57642020dn14-020014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304277PMC

A randomized controlled trial comparing the effectiveness of individual versus household treatment for Scabies in Lambaréné, Gabon.

PLoS Negl Trop Dis 2020 Jun 26;14(6):e0008423. Epub 2020 Jun 26.

Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.

Background: It is unclear whether individual treatment of scabies is similarly effective compared to household treatment. This study compared these two treatment strategies with topical benzyl benzoate for treating scabies in Lambaréné, Gabon.

Methods: Participants presenting with uncomplicated scabies were randomized into either the Individual Treatment group, where only the affected participants received treatment, or the Household Treatment group, where all family members were treated in parallel to the affected participants regardless of signs and symptoms. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008423DOI Listing

Application of a likelihood ratio test based method for safety signal detection to left ventricular assist devices.

J Biopharm Stat 2020 Jun 26:1-8. Epub 2020 Jun 26.

Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, U.S. Food and Drug Administration , Silver Spring, Maryland, USA.

Effective post-market safety surveillance of medical devices is critical for public health. However, many current statistical methods for safety signal detection do not control for type I error when assessing multiple device and adverse event (AE) combinations. This can result in increased false signals, underscoring the need for more robust statistical methods. Read More

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http://dx.doi.org/10.1080/10543406.2020.1783282DOI Listing

Parametric g-formula implementations for causal survival analyses.

Biometrics 2020 Jun 26. Epub 2020 Jun 26.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

The g-formula can be used to estimate the survival curve under a sustained treatment strategy. Two available estimators of the g-formula are noniterative conditional expectation and iterative conditional expectation. We propose a version of the iterative conditional expectation estimator and describe its procedures for deterministic and random treatment strategies. Read More

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http://dx.doi.org/10.1111/biom.13321DOI Listing

Publisher Correction: Re-estimation improved the performance of two Framingham cardiovascular risk equations and the Pooled Cohort equations: A nationwide registry analysis.

Sci Rep 2020 Jun 26;10(1):10778. Epub 2020 Jun 26.

Medical University of Vienna, CEMSIIS, Section for Clinical Biometrics, Vienna, Austria.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41598-020-67920-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316743PMC

Characteristics of Patients Who Achieve Serum Phosphorus Control on Sucroferric Oxyhydroxide or Sevelamer Carbonate: A post hoc Analysis of a Phase 3 Study.

Nephron 2020 Jun 25:1-12. Epub 2020 Jun 25.

Division of Nephrology, RWTH University Hospital Aachen, Aachen, Germany.

Introduction: Control of hyperphosphatemia in patients on dialysis remains a major challenge.

Objective: This study evaluated predictors of serum phosphorus (sP) control among dialysis patients treated with noncalcium, oral phosphate binder therapy in a phase 3 clinical trial.

Methods: Post hoc analyses were performed using data for patients with hyperphosphatemia who received 52 weeks of treatment with sucroferric oxyhydroxide (SFOH) or sevelamer carbonate (sevelamer). Read More

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http://dx.doi.org/10.1159/000507258DOI Listing

Concordance of early and late endpoints for community-acquired bacterial pneumonia trials.

Clin Infect Dis 2020 Jun 25. Epub 2020 Jun 25.

Office of Infectious Diseases, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD.

Background: While there are ongoing regulatory convergence efforts, differences remain in primary endpoints recommended for community-acquired bacterial pneumonia (CABP) trials. The US Food and Drug Administration recommends assessing CABP symptom resolution at an early time point (3-5 days after randomization). Other regulatory agencies recommend assessing overall clinical response at a later time point (5-10 days after therapy ends). Read More

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http://dx.doi.org/10.1093/cid/ciaa860DOI Listing

Morphologic characterization of the anterior inferior cerebellar artery: a direct anatomic study.

Neurol Res 2020 Jun 25:1-7. Epub 2020 Jun 25.

Department of Basic Sciences, Medicine School, Universidad Industrial De Santander , Bucaramanga, Colombia.

Objective: An adequate knowledge of the anterior inferior cerebellar artery (AICA) is oriented to the morphological sciences, clinical management and surgical planning of the posterior fossa. We aimed to determine the morphology of AICA in a sample from Colombian population.

Method: We studied 92 AICA from fresh cadavers. Read More

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http://dx.doi.org/10.1080/01616412.2020.1785743DOI Listing

Beer and Consumer Response Using Biometrics: Associations Assessment of Beer Compounds and Elicited Emotions.

Foods 2020 Jun 22;9(6). Epub 2020 Jun 22.

Digital Agriculture, Food and Wine Sciences Group, School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC 3010, Australia.

Some chemical compounds, especially alcohol, sugars, and alkaloids such as hordenine, have been reported as elicitors of different emotional responses. This preliminary study was based on six commercial beers selected according to their fermentation type, with two beers of each type (spontaneous, bottom, and top). Chemometry and sensory analysis were performed for all samples to determine relationships and patterns between chemical composition and emotional responses from consumers. Read More

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http://dx.doi.org/10.3390/foods9060821DOI Listing

Echocardiographic Characterization of Female Professional Basketball Players in the US.

JAMA Cardiol 2020 Jun 24. Epub 2020 Jun 24.

Division of Cardiology, Columbia University Irving Medical Center, New York, New York.

Importance: There is a paucity of data detailing cardiac remodeling in female athletes compared with male athletes. The lack of reference cardiac data for elite female basketball players or female athletes of similar size makes it difficult to differentiate athletic remodeling from potential underlying cardiac disorders in this population of athletes.

Objective: To assess cardiac structure and function in elite female basketball players. Read More

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http://dx.doi.org/10.1001/jamacardio.2020.0988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315385PMC

The Status Quo of Rare Diseases Centres for the Development of a Clinical Decision Support System - A Cross-Sectional Study.

Stud Health Technol Inform 2020 Jun;271:176-183

Medical Informatics Group, University Hospital Frankfurt, Frankfurt, Germany.

Clinical decision support systems (CDSS) help to improve the diagnostics and treatment of rare diseases (RD). As one of four funded consortia of the Medical Informatics Initiative supported by the Federal Ministry of Education and Research (BMBF, Germany), MIRACUM develops a clinical decision support system (CDSS) for RD based on distributed data of ten university hospitals. The CDSS will be developed at the Rare Diseases Centres (RDC) of the MIRACUM consortium. Read More

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http://dx.doi.org/10.3233/SHTI200094DOI Listing

Characterizing New Wintering Sites for Monarch Butterfly Colonies in Sierra Nevada, Mexico.

Insects 2020 Jun 21;11(6). Epub 2020 Jun 21.

National Center of Interdisciplinary Research on Conservation and Enhancement of Forest Ecosystems, National Institute for Forestry, Agriculture and Livestock Research, Progreso 5, Barrio de Santa Catarina, Coyoacan, Ciudad de Mexico 04010, Mexico.

Every year, (Linnaeus, 1758) travels to hibernate in oyamel fir forests located between the limits of the states of Michoacán and Mexico in Mexico. Climate change and anthropogenic actions are diminishing oyamel fir forests in Mexico, putting pressure on the habitats of monarch butterflies. In the last decade, new colonies outside their usual range have been predicted through modeling and reported by the National Commission on Protected Areas of Mexico. Read More

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http://dx.doi.org/10.3390/insects11060384DOI Listing

A constrained single-index regression for estimating interactions between a treatment and covariates.

Biometrics 2020 Jun 23. Epub 2020 Jun 23.

Department of Biostatistics, Columbia University, New York, New York.

We consider a single-index regression model, uniquely constrained to estimate interactions between a set of pretreatment covariates and a treatment variable on their effects on a response variable, in the context of analyzing data from randomized clinical trials. We represent interaction effect terms of the model through a set of treatment-specific flexible link functions on a linear combination of the covariates (a single index), subject to the constraint that the expected value given the covariates equals 0, while leaving the main effects of the covariates unspecified. We show that the proposed semiparametric estimator is consistent for the interaction term of the model, and that the efficiency of the estimator can be improved with an augmentation procedure. Read More

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http://dx.doi.org/10.1111/biom.13320DOI Listing

Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast.

Arch Toxicol 2020 Jun 22. Epub 2020 Jun 22.

Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.

Understanding intramammary estrogen homeostasis constitutes the basis of understanding the role of lifestyle factors in breast cancer etiology. Thus, the aim of the present study was to identify variables influencing levels of the estrogens present in normal breast glandular and adipose tissues (GLT and ADT, i.e. Read More

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http://dx.doi.org/10.1007/s00204-020-02807-1DOI Listing

Improving the evaluation of COPD exacerbation treatment effects by accounting for early treatment discontinuations: a post-hoc analysis of randomized clinical trials.

Respir Res 2020 Jun 22;21(1):158. Epub 2020 Jun 22.

BioPharma Early Biometrics and Statistical Innovation, Data Science & AI, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, SE-431 83, Mölndal, Sweden.

Background: Chronic obstructive pulmonary disease (COPD) clinical trials aimed at evaluating treatment effects on exacerbations often suffer from early discontinuations of randomized treatment. Treatment discontinuations imply a loss of information and should ideally be considered in the statistical analysis of trial results, particularly if the discontinuations are related to the disease or treatment itself. Here, we explore this issue by investigating (1) whether there exists an association between the risks of exacerbation and treatment discontinuation in COPD clinical trials and (2) whether disregarding this association can cause bias in exacerbation treatment effect estimates. Read More

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http://dx.doi.org/10.1186/s12931-020-01419-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310001PMC

Integrating a Secure and Generic Mobile App for Patient Reported Outcome Acquisition into an EHR Infrastructure Based on FHIR Resources.

Stud Health Technol Inform 2020 Jun;270:991-995

Department of Medical Informatics, Biometrics and Epidemiology, Chair of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Wetterkreuz 13, 91058 Erlangen, Germany.

Both patients and physicians of the University Hospital of Erlangen would welcome means of digital data exchange between patients and the hospital. This work presents a system's architecture, FHIR based data model, security measures, and application flow based on patient's smartphones and a public cloud infrastructure to obtain patient reported outcome measures and merge that information with clinical routine data. Read More

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http://dx.doi.org/10.3233/SHTI200310DOI Listing

Post-mortem Iris Decomposition and its Dynamics in Morgue Conditions.

J Forensic Sci 2020 Jun 22. Epub 2020 Jun 22.

Department of Ophthalmology, Medical University of Warsaw, Lindleya 4, Warsaw, 02-005, Poland.

With increasing interest in employing iris biometrics as a forensic tool for identification by investigation authorities, there is a need for a thorough examination and understanding of postmortem decomposition processes that take place within the human eyeball, especially the iris. This can prove useful for fast and accurate matching of antemortem with postmortem data acquired at crime scenes or mass casualties, as well as for ensuring correct dispatching of bodies from the incident scene to a mortuary or funeral homes. Following these needs of forensic community, this paper offers an analysis of the coarse effects of eyeball decay done from a perspective of automatic iris recognition. Read More

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http://dx.doi.org/10.1111/1556-4029.14488DOI Listing

Scalable Bayesian matrix normal graphical models for brain functional networks.

Biometrics 2020 Jun 22. Epub 2020 Jun 22.

Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, 30322.

Recently, there has been an explosive growth in graphical modeling approaches for estimating brain functional networks. In a detailed study, we show that surprisingly, standard graphical modeling approaches for fMRI data may not yield accurate estimates of the brain network due to the inability to suitably account for temporal correlations. We propose a novel Bayesian matrix normal graphical model that jointly models the temporal covariance and the brain network under a separable structure for the covariance to obtain improved estimates. Read More

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http://dx.doi.org/10.1111/biom.13319DOI Listing

MOMBAT: Heart rate monitoring from face video using pulse modeling and Bayesian tracking.

Comput Biol Med 2020 Jun 7;121:103813. Epub 2020 May 7.

Embedded system and Robotics, TCS Research and Innovation, Kolkata 700106, India. Electronic address:

A non-invasive yet inexpensive method for heart rate (HR) monitoring is of great importance in many real-world applications including healthcare, psychology understanding, affective computing and biometrics. Face videos are currently utilized for such HR monitoring, but unfortunately this can lead to errors due to the noise introduced by facial expressions, out-of-plane movements, camera parameters (like focus change) and environmental factors. We alleviate these issues by proposing a novel face video based HR monitoring method MOMBAT, that is, MOnitoring using Modeling and BAyesian Tracking. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2020.103813DOI Listing

A multicenter, phase I, pharmacokinetic study of osimertinib in cancer patients with normal renal function or severe renal impairment.

Pharmacol Res Perspect 2020 Aug;8(4):e00613

Medical Oncology Department, Bordeaux University Hospital, Saint-André Hospital, Bordeaux, France.

Osimertinib is a third-generation, irreversible, oral epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) that potently and selectively inhibits both EGFR-TKI sensitizing and EGFR T790M and has demonstrated efficacy in non-small cell lung cancer (NSCLC) central nervous system metastases. In this phase I study, we assessed the effects of normal renal function (NRF) and severe renal impairment (SRI) on the pharmacokinetics (PK) of osimertinib in patients with solid tumors. Part A: patients with NRF (creatinine clearance [CrCL] ≥90 mL/min), and SRI, (CrCL <30 mL/min), received a single 80-mg oral dose of osimertinib and standard PK measures were assessed. Read More

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http://dx.doi.org/10.1002/prp2.613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307240PMC

PI3K pathway protein analyses in metastatic breast cancer patients receiving standard everolimus and exemestane.

J Cancer Res Clin Oncol 2020 Jun 21. Epub 2020 Jun 21.

Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam/Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Purpose: Everolimus plus exemestane (EVE/EXE) is a registered treatment option for ER-positive, HER2-negative (ER +/HER2-) metastatic breast cancer (MBC), but resistance mechanisms limit efficacy. We aimed to find markers that might help select patients with a higher chance on benefit from EVE/EXE.

Methods: Immunohistochemistry (IHC) of PTEN, p-AKT(Thr308), p-AKT(Ser473), p-4EBP1, p-p70S6K, p-S6RP(Ser240/244), p-ERK1/2 and p-S6RP (Ser235/236) was performed on primary tumour tissue and on biopsies immediately taken from ER +/HER2- MBC patients before the start of standard EVE/EXE (Eudract 2013-004120-11). Read More

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http://dx.doi.org/10.1007/s00432-020-03291-xDOI Listing

Safety and immunomodulatory properties of equine peripheral blood-derived mesenchymal stem cells in healthy cats.

Vet Immunol Immunopathol 2020 Jun 11;227:110083. Epub 2020 Jun 11.

Department of Medical Imaging and Orthopedics of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium; Global Stem Cell Technology NV, Anacura Group, Noorwegenstraat 4, 9940, Evergem, Belgium. Electronic address:

Objective: Due to the immunomodulatory properties of mesenchymal stem cells (MSCs) through stimulation of endogenous immune cells by paracrine signals and cell contact, they have been proposed as alternative treatment option for many inflammatory and immune-mediated diseases in veterinary medicine. However, the long-term cultivation possibilities of feline MSCs are currently compromised due to a restricted proliferation capacity. Therefore, the xenogeneic use of equine peripheral blood-derived MSCs (ePB-MSCs) would present an interesting alternative thanks to their superior cultivation properties. Read More

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http://dx.doi.org/10.1016/j.vetimm.2020.110083DOI Listing

Developing and evaluating risk prediction models with panel current status data.

Biometrics 2020 Jun 19. Epub 2020 Jun 19.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115.

Panel current status data arise frequently in biomedical studies when the occurrence of a particular clinical condition is only examined at several prescheduled visit times. Existing methods for analyzing current status data have largely focused on regression modeling based on commonly used survival models such as the proportional hazards model and the accelerated failure time model. However, these procedures have the limitations of being difficult to implement and performing sub-optimally in relatively small sample sizes. Read More

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http://dx.doi.org/10.1111/biom.13317DOI Listing

Expectation and variance of the estimator of the maximized selection response of linear selection indices with normal distribution.

Theor Appl Genet 2020 Jun 20. Epub 2020 Jun 20.

Biometrics and Statistics Unit, International Maize and Wheat Improvement Center (CIMMYT), Apdo. Postal 6-641, 06600, Mexico City, Mexico.

Key Message: The expectation and variance of the estimator of the maximized index selection response allow the breeders to construct confidence intervals and to complete the analysis of a selection process. The maximized selection response and the correlation of the linear selection index (LSI) with the net genetic merit are the main criterion to compare the efficiency of any LSI. The estimator of the maximized selection response is the square root of the variance of the estimated LSI values multiplied by the selection intensity. Read More

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http://dx.doi.org/10.1007/s00122-020-03629-6DOI Listing

Image-Based Somatotype as a Biometric Trait for Non-Collaborative Person Recognition at a Distance and On-The-Move.

Sensors (Basel) 2020 Jun 17;20(12). Epub 2020 Jun 17.

Department of Computer Science, Norwegian University of Science and Technology, 7030 Trondheim, Norway.

It has recently been shown in Re-Identification (Re-ID) work that full-body images of people reveal their somatotype, even after change in apparel. A significant advantage of this biometric trait is that it can easily be captured, even at a distance, as a full-body image of a person, taken by a standard 2D camera. In this work, full-body image-based somatotype is investigated as a novel soft biometric feature for person recognition at a distance and on-the-move. Read More

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http://dx.doi.org/10.3390/s20123419DOI Listing

The Rise of Biometrics in Sports.

Authors:
Mary Bates

IEEE Pulse 2020 May-Jun;11(3):25-28

Athletes-and the cadre of professionals who surround them-are always looking for an edge over their opponents. Advances in technology have now made a whole new class of information readily available to athletes, coaches, trainers, and even fans. It's called biometrics, the science of measuring and analyzing data collected from the body, such as heart rate or hormone levels. Read More

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http://dx.doi.org/10.1109/MPULS.2020.2993708DOI Listing

Associations between HbA1c and mortality over long-term follow-up: Results from the KORA S4 and the Heinz Nixdorf Recall Study.

Diabetes Metab Res Rev 2020 Jun 18:e3369. Epub 2020 Jun 18.

German Center for Diabetes Research (DZD), München-Neuherberg, Germany.

Aims: There is limited knowledge about mortality risk in persons with increased HbA1c levels below the diabetes threshold. Moreover, little is known about how associations between increased HbA1c and mortality depend on the length of follow-up. Therefore, we studied associations between HbA1c and mortality over long-term follow-up in persons with and without known diabetes. Read More

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http://dx.doi.org/10.1002/dmrr.3369DOI Listing

Semiparametric regression calibration for general hazard models in survival analysis with covariate measurement error; surprising performance under linear hazard.

Biometrics 2020 Jun 18. Epub 2020 Jun 18.

Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia.

Observational epidemiological studies often confront the problem of estimating exposure-disease relationships when the exposure is not measured exactly. Regression calibration (RC) is a common approach to correct for bias in regression analysis with covariate measurement error. In survival analysis with covariate measurement error, it is well known that the RC estimator may be biased when the hazard is an exponential function of the covariates. Read More

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http://dx.doi.org/10.1111/biom.13318DOI Listing

Spatial regression and spillover effects in cluster randomized trials with count outcomes.

Biometrics 2020 Jun 18. Epub 2020 Jun 18.

MRC Tropical Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

This paper describes methodology for analyzing data from cluster randomized trials with count outcomes, taking indirect effects as well spatial effects into account. Indirect effects are modeled using a novel application of a measure of depth within the intervention arm. Both direct and indirect effects can be estimated accurately even when the proposed model is misspecified. Read More

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http://dx.doi.org/10.1111/biom.13316DOI Listing

Adjuvant chemotherapy in small node-negative triple-negative breast cancer.

Eur J Cancer 2020 Jun 14;135:66-74. Epub 2020 Jun 14.

Department of Medical Oncology, The Netherlands Cancer Institute, PO Box 90203, 1006 BE, Amsterdam, the Netherlands. Electronic address:

Background: Recommendations on adjuvant chemotherapy in pT1N0M0 triple-negative breast cancer (TNBC) differ among international guidelines owing to lack of randomized trial data. We evaluated associations of adjuvant chemotherapy with a long-term outcome in a population-based cohort of pT1N0M0 TNBC.

Methods: All patients diagnosed with pT1N0M0 TNBC in the Netherlands between 2005 and 2016 were identified from the Netherlands Cancer Registry. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.033DOI Listing

Inverse probability of treatment analysis of open VS Endovascular repair in ruptured infrarenal aortic aneurysm - Cohort study.

Int J Surg 2020 Jun 15. Epub 2020 Jun 15.

Department of Surgery, Division of Vascular Surgery, Medical University of Vienna, Austria. Electronic address:

Background: To compare open repair (OR) with EVAR for the management of ruptured infrarenal abdominal aortic aneurysms (RAAA) in a cohort study over a time period of 15 years with inverse probability of treatment weights.

Material And Methods: From 2000/01 through 2015/12 136 patients were treated for RAAA, 98 (72.1%) underwent OR, 38 (27. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.05.090DOI Listing

Cervical cancer screening in rural Ethiopia: a cross- sectional knowledge, attitude and practice study.

BMC Cancer 2020 Jun 17;20(1):563. Epub 2020 Jun 17.

Institute of Medical Epidemiology, Biometrics and Informatics, Martin-Luther-Universität Halle-Wittenberg, 06097, Halle (Saale), Germany.

Background: Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This study aims to assess knowledge and attitude towards cervical cancer and its prevention, as well as practice of cervical cancer screening. Read More

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http://dx.doi.org/10.1186/s12885-020-07060-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298871PMC
June 2020
3.362 Impact Factor

The value of fetal growth biometry velocities to predict large for gestational age (LGA) infants.

J Matern Fetal Neonatal Med 2020 Jun 16:1-6. Epub 2020 Jun 16.

Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

The use of growth velocities derived from fetal biometrics have been suggested to improve prediction of large for gestational age (LGA). Our objective was to determine if ultrasonographic growth velocities (GV) for abdominal circumference (AC) and estimated fetal weight (EFW) improve the prediction of LGA infants when compared to Hadlock EFW. This was a secondary analysis of data from a prospective study of women referred for growth ultrasounds during the 3rd trimester. Read More

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http://dx.doi.org/10.1080/14767058.2020.1779214DOI Listing

Performance of an open source facial recognition system for unique patient matching in a resource-limited setting.

Int J Med Inform 2020 Jun 4;141:104180. Epub 2020 Jun 4.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA; Institute of Biomedical Informatics, Moi University, Eldoret, Kenya. Electronic address:

Background: The lack of unique patient identifiers is a challenge to patient care in developing countries. Probabilistic and deterministic matching approaches remain sub-optimal. However, affordable and scalable biometric solutions have not been rigorously evaluated in these settings. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2020.104180DOI Listing

Assessment of Chinese medicine for coronavirus-related pneumonia: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(24):e20613

Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, Beijing.

Background: The 2019 novel coronavirus disease has caused a global pandemic with substantial morbidity and mortality. Chinese medicine has been extensively employed in the coronavirus-related pandemic in China. We aim to assess the efficacy and safety of Chinese medicine in treatment of coronavirus-related pneumonia with the updated results of relevant clinical trials. Read More

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http://dx.doi.org/10.1097/MD.0000000000020613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302632PMC
June 2020
5.723 Impact Factor

Unknown confounders did not bias the treatment effect when improving balance of known confounders in randomized trials.

J Clin Epidemiol 2020 Jun 12. Epub 2020 Jun 12.

German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Institute for Biometrics and Epidemiology.

Objective: To measure if improving balance in known and observed confounders by propensity score (PS) matching yields different treatment effect estimates in randomized controlled trials (RCTs), thus indirectly measuring the influence of unknown confounders.

Study Design And Setting: Analysis of individual patient data of 26 large RCTs and comparison of agreement between PS matched samples and the RCT results on one hand to the agreement between subsamples of RCTs (with sample sizes equal to the sample sizes of the PS matched samples) and RCTs on the other by Bland-Altman-Plots and corresponding intra-class correlation coefficients.

Results: We included data on 213 outcomes from 37 treatment comparisons with 193,620 patients from 26 trials. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.012DOI Listing

A Bayesian approach in design and analysis of pediatric cancer clinical trials.

Pharm Stat 2020 Jun 14. Epub 2020 Jun 14.

Division of Biometrics V, Office of Biostatistics, Office of Translational Sciences, Center of Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

It is well recognized that cancer drug development for children and adolescents has many challenges, from biological and societal to economic. Pediatric cancer consists of a diverse group of rare diseases, and the relatively small population of children with multiple, disparate tumor types across various age groups presents a significant challenge for drug development programs as compared to oncology drug development programs for adults. Due to the different types of cancers, limited opportunities exist for extrapolation of efficacy from adult cancer indications to children. Read More

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http://dx.doi.org/10.1002/pst.2039DOI Listing