9,582 results match your criteria Biometrics [Journal]


Mirror and Vibration Therapies Effects on the Upper Limbs of Hemiparetic Patients after Stroke: A Pilot Study.

Rehabil Res Pract 2018 4;2018:6183654. Epub 2018 Nov 4.

State University of Piauí, Department of Physical Therapy, Teresina, PI, Brazil.

Background/aim: To evaluate, in this pilot study, the effects of the mirror (MT) and vibration therapies (VT) on the functionality of hemiparesis patients after stroke.

Materials And Methods: Twenty-one individuals after stroke with upper limb hemiparesis were randomized into control group (CG), Mirror Therapy Group (MTG), and Vibration Therapy Group (VTG). The functionality was evaluated before and after 12 sessions with three tests (i) Mobility Index Rivermead, (ii) Motor Function Wolf Test (time, functional ability), and (iii) Jebsen Taylor Test. Read More

View Article
November 2018
1 Read

Invitation to Screening Colonoscopy in the Population at Familial Risk for Colorectal Cancer.

Dtsch Arztebl Int 2018 Oct;115(43):715-722

Institute for General Medicine, Faculty of Medicine, University of Halle-Wittenberg, Halle; Institute for Health and Nursing Sciences, Faculty of Medicine, University of Halle-Wittenberg, Halle; Director Emeritus, Department of Medicine C, Ludwigshafen Hospital, c/o LebensBlicke Foundation, Ludwigshafen; Department of Internal Medicine I, Ulm University Hospital, Ulm; Department of Medicine I, Braunschweig Municipal Hospital, Braunschweig; Department of Gastroenterology, Celle General Hospital, Celle; Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen; Faculty of Human and Health Sciences, University of Bremen; Institute for Medical Epidemiology, Biometrics, and Information Science, Faculty of Medicine, University of Halle-Wittenberg, Halle; Nursing Research Unit, Halle University Hospital, Halle: Madeleine Ritter-Herschbach, MScN, RN; Department for Health, University of Bath, Claverton Down, Bath, UK.

Background: Screening colonoscopy can lower the incidence of colorectal cancer (CRC), yet participation rates are low even in groups at high risk. The goal of this study was to double the rate of participation in screening colonoscopy among persons at familial risk and then to determine the frequency of neoplasia in this risk group.

Methods: In a nationwide, cluster-randomized, multicenter study, first-degree relatives (FDR) of patients with CRC across Germany received written informational materials concerning the familial risk of CRC, along with an invitation to undergo colonoscopy. Read More

View Article
October 2018

Multiple primary malignancies in patients with anal squamous cell carcinoma.

J Gastrointest Oncol 2018 Oct;9(5):853-857

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.

Prior studies examining the risk of second primary malignancy (SPM) after a first primary cancer generally have used large datasets such as the Surveillance, Epidemiology, and End Results (SEER) registry and excluded survivors of previous primaries and developers of synchronous primaries. The goal of this study was to provide a more complete representation of multiple cancer risk in squamous cell carcinoma of the anus (SCCA) patients. A single-institution retrospective study of 46 patients treated definitively for SCCA between January 2006 and July 2017 was conducted. Read More

View Article
October 2018
1 Read

Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries.

Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, Population Health Research Institute, McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada.

Aims: To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events.

Methods And Results: We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the associations between them and the composite outcome of deaths and major cardiovascular events in 116 632 participants from seven regions. After a median follow-up of 7. Read More

View Article
December 2018
1 Read

Linked Matrix Factorization.

Biometrics 2018 Dec 5. Epub 2018 Dec 5.

Division of Biostatistics, University of Minnesota, Minneapolis, MN 55455, USA.

Several recent methods address the dimension reduction and decomposition of linked high-content data matrices. Typically, these methods consider one dimension, rows or columns, that is shared among the matrices. This shared dimension may represent common features measured for different sample sets (horizontal integration) or a common sample set with features from different platforms (vertical integration). Read More

View Article
December 2018

Osimertinib in patients with T790M mutation-positive, advanced non-small cell lung cancer: Long-Term follow-up from a pooled analysis of 2 phase 2 studies.

Cancer 2018 Dec 4. Epub 2018 Dec 4.

Division of Medical Oncology, The Ottawa Hospital Cancer Center, University of Ottawa, Ottawa, Ontario, Canada.

Background: Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is selective for both EGFR-TKI-sensitizing and T790M (threonine-to-methionine substitution at codon 790)-resistance mutations. The authors present long-term follow-up data from a preplanned, pooled analysis of phase 2 studies, the AZD9291 First Time in Patients Ascending Dose Study (AURA) extension trial (clincialtrials.gov identifier NCT01802632) and the AURA2 trial (NCT02094261). Read More

View Article
December 2018
1 Read

Automated Affect Detection in Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Pilot Study.

Proc ACM Int Conf Multimodal Interact 2018 Oct;2018:40-44

Baylor College of Medicine, Houston, Texas.

Automated measurement of affective behavior in psychopathology has been limited primarily to screening and diagnosis. While useful, clinicians more often are concerned with whether patients are improving in response to treatment. Are symptoms abating, is affect becoming more positive, are unanticipated side effects emerging? When treatment includes neural implants, need for objective, repeatable biometrics tied to neurophysiology becomes especially pressing. Read More

View Article
October 2018

Regional differences of macrovascular disease in Northeast and South Germany: the population-based SHIP-TREND and KORA-F4 studies.

BMC Public Health 2018 Dec 3;18(1):1331. Epub 2018 Dec 3.

Institute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.

Background: Previous studies found regional differences in the prevalence and incidence of type 2 diabetes between Northeast and South of Germany. The aim of this study was to investigate if regional variations are also present for macrovascular disease in people with type 2 diabetes and in the general population. A further aim was to investigate if traditional risk factors of macrovascular complications can explain these regional variations. Read More

View Article
December 2018
1 Read

Behavior in dogs with spontaneous hypothyroidism during treatment with levothyroxine.

J Vet Intern Med 2018 Nov 30. Epub 2018 Nov 30.

Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Background: Thyroid hormone supplementation anecdotally has been described as a valid treatment option for dogs with aggression-related problems. However, prospective, controlled, and blinded trials evaluating behavior and neurohormonal status in hypothyroid dogs during treatment with levothyroxine are lacking.

Objective: Levothyroxine supplementation will have a significant influence on the behavior and neurohormonal status of dogs with spontaneous hypothyroidism. Read More

View Article
November 2018

Quantifying Immunoscore performance.

Lancet 2018 Nov;392(10158):1624

Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

View Article
November 2018

Generalizing causal inferences from individuals in randomized trials to all trial-eligible individuals.

Biometrics 2018 Nov 29. Epub 2018 Nov 29.

Department of Epidemiology, Harvard-T.H. Chan School of Public Health, Boston, MA, USA.

We consider methods for causal inference in randomized trials nested within cohorts of trial-eligible individuals, including those who are not randomized. We show how baseline covariate data from the entire cohort, and treatment and outcome data only from randomized individuals, can be used to identify potential (counterfactual) outcome means and average treatment effects in the target population of all eligible individuals. We review identifiability conditions, propose estimators, and assess the estimators' finite-sample performance in simulation studies. Read More

View Article
November 2018

Optimal design of multiple-objective Lot Quality Assurance Sampling (LQAS) plans.

Biometrics 2018 Nov 29. Epub 2018 Nov 29.

Department of Biostatistics, Fielding School of Public Health, UCLA, 10833 Le Conte Ave., Los Angeles, California 90095-1772, USA.

Lot Quality Assurance Sampling (LQAS) plans are widely used for health monitoring purposes. We propose a systematic approach to design multiple-objective LQAS plans that meet user-specified type 1 and 2 error rates and targets for selected diagnostic accuracy metrics. These metrics may include sensitivity, specificity, positive predictive value, and negative predictive value in high or low anticipated prevalence rate populations. Read More

View Article
November 2018

Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program).

Cardiovasc Diabetol 2018 Nov 28;17(1):150. Epub 2018 Nov 28.

University of Leicester, University Rd, Leicester, LE1 7RH, UK.

Background: The global prevalence of type 2 diabetes-related complications is not well described. We assessed prevalence of vascular complications at baseline in DISCOVER (NCT02322762; NCT02226822), a global, prospective, observational study program of 15,992 patients with type 2 diabetes initiating second-line therapy, conducted across 38 countries.

Methods: Patients were recruited from primary and specialist healthcare settings. Read More

View Article
November 2018

Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study.

Diabetologia 2018 Nov 28. Epub 2018 Nov 28.

Odense Patient data Exploratory Network (OPEN), Odense University Hospital/Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Aims/hypothesis: Against a background of a near-universally increasing incidence of childhood type 1 diabetes, recent reports from some countries suggest a slowing in this increase. Occasional reports also describe cyclical variations in incidence, with periodicities of between 4 and 6 years.

Methods: Age/sex-standardised incidence rates for the 0- to 14-year-old age group are reported for 26 European centres (representing 22 countries) that have registered newly diagnosed individuals in geographically defined regions for up to 25 years during the period 1989-2013. Read More

View Article
November 2018

Dietary fat and risk of type 2 diabetes.

Curr Opin Lipidol 2018 Nov 21. Epub 2018 Nov 21.

Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf.

Purpose Of Review: Nutrition recommendations emphasize that not only dietary fat quantity but also fat quality plays a role in the prevention of type 2 diabetes (T2D). The aim of this review is to summarize the evidence for dietary fat and risk of T2D, to highlight recent findings and point out future research directions.

Recent Findings: Total fat intake was not associated with risk of T2D, whereas the findings on fatty acids (FAs) and risk of T2D were controversial. Read More

View Article
November 2018
13 Reads

Evaluating a shortened interpretation criterion for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism: A 5-minutes criterion in primary hyperparathyroidism and intraoperative algorithm.

Head Neck 2018 Nov 26. Epub 2018 Nov 26.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.

Background: Most criteria require a parathyroid hormone (PTH) decline of ≥50% within 10 minutes after excision of the gland during surgery for primary hyperparathyroidism. The aim was to evaluate a model allowing earlier prediction of cure.

Methods: One thousand eighteen patients with primary hyperparathyroidism were included. Read More

View Article
November 2018
2 Reads

Comprehensive longitudinal surveillance of the IgG autoantibody repertoire in established systemic lupus erythematosus.

Arthritis Rheumatol 2018 Nov 26. Epub 2018 Nov 26.

Hiller Research Center Rheumatology at University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine-University, Merowingerplatz 1a, 40225, Düsseldorf.

Objective: to appraise the role of epitope spreading in established human systemic lupus erythematosus (SLE).

Methods: IgG-autoantibody reactivity to 398 distinct recombinant proteins was measured in 69 SLE patients over 6 years and compared to 45 controls. Changes in mean fluorescence intensity (MFI), number of autoantibodies to distinct antigens, and reactivity to distinct clones of selected established antigenic targets U1-RNP, Sm, and ribosomal P representing epitope fine mapping were assessed. Read More

View Article
November 2018
2 Reads

Management and prognostic factors of epithelioid trophoblastic tumors: Results from the International Society for the Study of Trophoblastic Diseases database.

Gynecol Oncol 2018 Nov 22. Epub 2018 Nov 22.

Department of Medical Oncology, Charing Cross Hospital, London, United Kingdom.

Objective: Epithelioid Trophoblastic Tumor (ETT) is an extremely rare form of Gestational Trophoblastic Neoplasia (GTN). Knowledge on prognostic factors and optimal management is limited. We identified prognostic factors, optimal treatment, and outcome from the world's largest case series of patients with ETT. Read More

View Article
November 2018
8 Reads

MR Imaging Evaluation of the Kidneys in Patients with Reduced Kidney Function: Noncontrast Techniques Versus Contrast-Enhanced Techniques.

Magn Reson Imaging Clin N Am 2019 Feb;27(1):45-57

Department of Medical Imaging, University of Arizona, 1501 North Campbell Avenue, PO Box 245067, Tucson, AZ 85724-5067, USA. Electronic address:

MR imaging has been optimized for the evaluation of a multitude of disease processes affecting the kidneys. A wide variety of noncontrast methods are available for the evaluation of both kidney structure and function, which are especially useful in clinical scenarios that obviate the use of intravenous contrast. Contrast-enhanced methods remain important, especially for tumor evaluation, and are used increasingly for functional analysis of quantitative biometrics, such as glomerular filtration rate and kidney blood flow. Read More

View Article
February 2019

Health-related quality of life in long-term survivors of colorectal cancer and its association with all-cause mortality: a German cohort study.

BMC Cancer 2018 Nov 22;18(1):1156. Epub 2018 Nov 22.

Institute of Epidemiology, University of Kiel, University Hospital Schleswig-Holstein, Niemannsweg 11, 24105, Kiel, Germany.

Background: The group of colorectal cancer (CRC) survivors continues to grow worldwide. Understanding health-related quality of life (HRQOL) determinants and consequences of HRQOL impairments in long-term CRC survivors may help to individualize survivorship care plans. We aimed to i) examine the HRQOL status of CRC long-term survivors, ii) identify cross-sectional sociodemographic and clinical correlates of HRQOL, and iii) investigate the prospective association of HRQOL after CRC diagnosis with all-cause mortality. Read More

View Article
November 2018
10 Reads

Treatment of opioid dependence with buprenorphine/naloxone sublingual tablets: A phase 3 randomized, double-blind, placebo-controlled trial.

Asia Pac Psychiatry 2018 Nov 20:e12344. Epub 2018 Nov 20.

The Second Xiangya Hospital of Central South University, Changsha, China.

Introduction: The purpose of the study is to evaluate the efficacy and safety of buprenorphine/naloxone sublingual tablets for the treatment of opioid dependence in Chinese adults.

Methods: This multicenter, double-blind, placebo-controlled study included four periods: induction (3-5 days), stabilization (7-21 days), randomization/treatment (6 weeks), and postmedication follow-up (1 week). A total of 442 participants with opioid dependence were enrolled; 260 were randomized to buprenorphine/naloxone or placebo. Read More

View Article
November 2018
2 Reads

Molecular Ontogeny of First-Feeding European Eel Larvae.

Front Physiol 2018 23;9:1477. Epub 2018 Oct 23.

National Institute of Aquatic Resources, Technical University of Denmark, Kongens Lyngby, Denmark.

Digestive system functionality of fish larvae relies on the onset of genetically pre-programmed and extrinsically influenced digestive functions. This study explored how algal supplementation (green-water) until 14 days post hatch (dph) and the ingestion of food [enriched rotifer () paste] from 15 dph onward affects molecular maturation and functionality of European eel larval ingestion and digestion mechanisms. For this, we linked larval biometrics to expression of genes relating to appetite [ghrelin (), cholecystokinin ()], food intake [proopiomelanocortin ()], digestion [trypsin (), triglyceride lipase (), amylase ()], energy metabolism [ATP synthase F0 subunit 6 (), cytochrome--oxidase 1 ()], growth [insulin-like growth factor ()] and thyroid metabolism [thyroid hormone receptors (, )]. Read More

View Article
October 2018

Nonparametric Group Sequential Methods for Evaluating Survival Benefit from Multiple Short-Term Follow-up Windows.

Biometrics 2018 Nov 20. Epub 2018 Nov 20.

The University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, TX 77030, USA.

This manuscript takes a fresh look at group sequential methods applied to two-sample tests of censored survival data and proposes an alternative method of defining and evaluating treatment benefit. Our method re-purposes traditional censored event time data into a sequence of short-term outcomes taken from (potentially overlapping) follow-up windows. A new two-sample restricted means test based on this restructured follow-up data is proposed along with group sequential methods for its use in the clinical trial setting. Read More

View Article
November 2018

Integrative Multi-View Regression: Bridging Group-Sparse and Low-Rank Models.

Biometrics 2018 Nov 20. Epub 2018 Nov 20.

Department of Statistics, University of Connecticut, Storrs, CT.

Multi-view data have been routinely collected in various _elds of science and engineering. A general problem is to study the predictive association between multivariate responses and multi-view predictor sets, all of which can be of high dimensionality. It is likely that only a few views are relevant to prediction, and the predictors within each relevant view contribute to the prediction collectively rather than sparsely. Read More

View Article
November 2018
3 Reads

Effects of deferasirox dose and decreasing serum ferritin concentrations on kidney function in paediatric patients: an analysis of clinical laboratory data from pooled clinical studies.

Lancet Child Adolesc Health 2018 Nov 16. Epub 2018 Nov 16.

Division of Epidemiology, Food and Drug Administration, Silver Spring, MD, USA.

Background: Serious and fatal deferasirox-induced kidney injury has been reported in paediatric patients. This study aimed to investigate the effects of deferasirox dose and serum ferritin concentrations on kidney function and the effect of impaired kidney function on dose-normalised deferasirox minimum plasma concentration (C).

Methods: We did a case-control analysis using pooled data from ten clinical studies. Read More

View Article
November 2018

Human ancestry indentification under resource constraints -- what can one chromosome tell us about human biogeographical ancestry?

BMC Med Genomics 2018 Nov 20;11(Suppl 5). Epub 2018 Nov 20.

Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, WV, USA.

Background: While continental level ancestry is relatively simple using genomic information, distinguishing between individuals from closely associated sub-populations (e.g., from the same continent) is still a difficult challenge. Read More

View Article
November 2018

A Smoothing-based Goodness-of-Fit Test of Covariance for Functional Data.

Biometrics 2018 Nov 19. Epub 2018 Nov 19.

Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA.

Functional data methods are often applied to longitudinal data as they provide a more flexible way to capture dependence across repeated observations. However, there is no formal testing procedure to determine if functional methods are actually necessary. We propose a goodness-of-fit test for comparing parametric covariance functions against general nonparametric alternatives for both irregularly observed longitudinal data and densely observed functional data. Read More

View Article
November 2018

Two-stage hepatectomy for colorectal liver metastases: Pathologic response to preoperative chemotherapy is associated with second-stage completion and longer survival.

Surgery 2018 Nov 16. Epub 2018 Nov 16.

Anatomopathology Department, Institut Régional du Cancer de Montpellier (ICM), Université de Montpellier, France; Anatomopathology Department, Centre Hospitalier Universitaire de Caen, Caen, France.

Background: Two-stage hepatectomy of bilobar colorectal liver metastases is widely used and shows encouraging survival results. However, the risk of dropout after the first stage remains high and is associated with poor survival. The objective of our study was to evaluate the factors associated with long-term survival based on the pathologic response to preoperative systemic chemotherapy in colorectal liver metastases patients who underwent two-stage hepatectomy. Read More

View Article
November 2018
2 Reads

Trends and outcomes of lymphadenectomy for nonmetastatic renal cell carcinoma: A propensity score-weighted analysis of the National Cancer Database.

Urol Oncol 2018 Nov 13. Epub 2018 Nov 13.

Section of Urologic Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ. Electronic address:

Purpose: Lymph node (LN) involvement in renal cell carcinoma (RCC) is associated with a poor prognosis. While lymph node dissection (LND) may provide diagnostic information, its therapeutic benefit remains controversial. Thus, the aim of our study is to analyze survival outcomes after LND for nonmetastatic RCC and to characterize contemporary practice patterns. Read More

View Article
November 2018

A Bayesian Hidden Markov Model for Detecting Differentially Methylated Regions.

Authors:
Tieming Ji

Biometrics 2018 Nov 15. Epub 2018 Nov 15.

Department of Statistics, University of Missouri at Columbia, Columbia, Missouri, 65211, USA.

Alterations in DNA methylation have been linked to the development and progression of many diseases. The bisulfite sequencing technique presents methylation profiles at base resolution. Count data on methylated and unmethylated reads provide information on the methylation level at each CpG site. Read More

View Article
November 2018
1 Read

Feasibility, Acceptability, and Adoption of Digital Fingerprinting During Contact Investigation for Tuberculosis in Kampala, Uganda: A Parallel-Convergent Mixed-Methods Analysis.

J Med Internet Res 2018 Nov 15;20(11):e11541. Epub 2018 Nov 15.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States.

Background: In resource-constrained settings, challenges with unique patient identification may limit continuity of care, monitoring and evaluation, and data integrity. Biometrics offers an appealing but understudied potential solution.

Objective: The objective of this mixed-methods study was to understand the feasibility, acceptability, and adoption of digital fingerprinting for patient identification in a study of household tuberculosis contact investigation in Kampala, Uganda. Read More

View Article
November 2018
1 Read
3.430 Impact Factor

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.

EBioMedicine 2018 Nov 13. Epub 2018 Nov 13.

Center for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Medical Research Centre (MRC) Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland. Electronic address:

Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.

Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n = 18,212). Read More

View Article
November 2018
3 Reads

Human-level Performance On Automatic Head Biometrics In Fetal Ultrasound Using Fully Convolutional Neural Networks.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:714-717

Measurement of head biometrics from fetal ultrasonography images is of key importance in monitoring the healthy development of fetuses. However, the accurate measurement of relevant anatomical structures is subject to large inter-observer variability in the clinic. To address this issue, an automated method utilizing Fully Convolutional Networks (FCN) is proposed to determine measurements of fetal head circumference (HC) and biparietal diameter (BPD). Read More

View Article
July 2018
1 Read

Metal and metalloid exposure and oxidative status in free-living individuals of Myotis daubentonii.

Ecotoxicol Environ Saf 2018 Nov 12;169:93-102. Epub 2018 Nov 12.

Finnish Museum of Natural History, University of Helsinki, Finland.

Metal elements, ubiquitous in the environment, can cause negative effects in long-lived organisms even after low but prolonged exposure. Insectivorous bats living near metal emission sources can be vulnerable to such contaminants. Although it is known that bats can bioaccumulate metals, little information exists on the effects of metal elements on their physiological status. Read More

View Article
November 2018

The Single-Index/Cox Mixture Cure Model.

Biometrics 2018 Nov 14. Epub 2018 Nov 14.

Institute of Statistics, Biostatistics and Actuarial Sciences, UCLouvain, Louvain-la-Neuve, Belgium.

In survival analysis it often happens that a certain fraction of the subjects under study never experience the event of interest, i.e. they are considered 'cured'. Read More

View Article
November 2018

Composite Kernel Machine Regression based on Likelihood Ratio Test for Joint Testing of Genetic and Gene-environment Interaction Effect.

Biometrics 2018 Nov 14. Epub 2018 Nov 14.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Most common human diseases are a result from the combined effect of genes, the environmental factors and their interactions such that including gene-environment (GE) interactions can improve power in gene mapping studies. The standard strategy is to test the SNPs, one-by-one, using a regression model that includes both the SNP effect and the GE interaction. However, the SNP-by-SNP approach has serious limitations, such as the inability to model epistatic SNP effects, biased estimation and reduced power. Read More

View Article
November 2018

Causal inference accounting for unobserved confounding after outcome regression and doubly robust estimation.

Biometrics 2018 Nov 14. Epub 2018 Nov 14.

Department of Statistics, USBE, Umeå University, 901 87, Umeå, Sweden.

Causal inference with observational data can be performed under an assumption of no unobserved confounders (unconfoundedness assumption). There is, however, seldom clear subject-matter or empirical evidence for such an assumption. We therefore develop uncertainty intervals for average causal effects based on outcome regression estimators and doubly robust estimators, which provide inference taking into account both sampling variability and uncertainty due to unobserved confounders. Read More

View Article
November 2018

Convex Clustering Analysis for Histogram-Valued Data.

Biometrics 2018 Nov 14. Epub 2018 Nov 14.

Dept. of Mathematics Education, Korea National U. of Education, Cheongju, Chungbuk, 28173, Korea.

In recent years, there has been increased interest in symbolic data analysis, including for exploratory analysis, supervised and unsupervised learning, time series analysis, etc. Traditional statistical approaches that are designed to analyze single-valued data are not suitable because they cannot incorporate the additional information on data structure available in symbolic data, and thus new techniques have been proposed for symbolic data to bridge this gap. In this paper, we develop a regularized convex clustering approach for grouping histogram-valued data. Read More

View Article
November 2018

Exact Inference on the Random-Effects Model for Meta-Analyses with Few Studies.

Biometrics 2018 Nov 14. Epub 2018 Nov 14.

Department of Biomedical Data Science, Stanford University.

We describe an exact, unconditional, non-randomized procedure for producing confidence intervals for the grand mean in a normal-normal random effects meta-analysis. The procedure targets meta-analyses based on too few primary studies, ≤ 7; say, to allow for the conventional asymptotic estimators, e.g. Read More

View Article
November 2018
2 Reads

A robust RUV-testing procedure via γ-divergence.

Authors:
Hung Hung

Biometrics 2018 Nov 14. Epub 2018 Nov 14.

Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taiwan.

Identification of differentially expressed genes (DE genes) is commonly conducted in modern biomedical research. However, unwanted variation inevitably arises during the data collection process, which can make the detection results heavily biased. Various methods have been suggested for removing the unwanted variation while keeping the biological variation to ensure a reliable analysis result. Read More

View Article
November 2018
2 Reads

A Neuro-Inspired System for Online Learning and Recognition of Parallel Spike Trains, Based on Spike Latency, and Heterosynaptic STDP.

Front Neurosci 2018 31;12:780. Epub 2018 Oct 31.

UCM-UPM Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Madrid, Spain.

Humans perform remarkably well in many cognitive tasks including pattern recognition. However, the neuronal mechanisms underlying this process are not well understood. Nevertheless, artificial neural networks, inspired in brain circuits, have been designed and used to tackle spatio-temporal pattern recognition tasks. Read More

View Article
October 2018
3 Reads

External validation of two Framingham cardiovascular risk equations and the Pooled Cohort equations: A nationwide registry analysis.

Int J Cardiol 2018 Nov 5. Epub 2018 Nov 5.

Medical University of Vienna, CeMSIIS, Section for Clinical Biometrics, Vienna, Austria. Electronic address:

Background: Cardiovascular prevention guidelines advocate the use of statistical risk equations to predict individual cardiovascular risk. However, predictive accuracy and clinical value of existing equations may differ in populations other than the one used for their development. Using baseline and follow-up data of the Austrian health-screening program, we assessed discrimination, calibration, and clinical utility of three widely recommended equations-the Framingham 1991 and 2008 general cardiovascular disease (CVD) equations, and the Pooled Cohort equations predicting atherosclerotic CVD. Read More

View Article
November 2018
4 Reads

von Willebrand Factor Antigen Predicts Outcomes in Patients after Liver Resection of Hepatocellular Carcinoma.

Gut Liver 2018 Nov 12. Epub 2018 Nov 12.

Department of General Surgery, Medical University Vienna, Vienna, Austria.

Background/aims: von Willebrand factor antigen (vWF-Ag) is a noninvasive predictor of portal hypertension that serves as a negative prognostic marker in various malignancies. Increased portal hypertension is associated with higher postoperative morbidity and decreased survival after hepatectomy. The purpose of this study was to determine the correlation between vWF-Ag, postoperative morbidity and oncological outcome. Read More

View Article
November 2018
1 Read

Psychiatric Disorders in Complex Regional Pain Syndrome (CRPS): The Role of the Consultation-Liaison Psychiatrist.

Pain Res Manag 2018 17;2018:2894360. Epub 2018 Oct 17.

Department of Anaesthesiology and Intensive Care Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

Background: Complex regional pain syndrome (CRPS) is a multifactorial disorder with complex aetiology and pathogenesis. At the outpatient pain clinic of Magdeburg University Hospital, all patients, without exception, are subject to permanent psychiatric care delivered by a consultation-liaison psychiatrist. In CRPS, psychological stabilization and treatment of the neuropathic aspects are equally important. Read More

View Article
October 2018

Rationale and Design of the IROCAS Study: Multicenter, International, Randomized Phase 3 Trial Comparing Adjuvant Modified (m) FOLFIRINOX to mFOLFOX6 in Patients With High-Risk Stage III (pT4 and/or N2) Colon Cancer-A UNICANCER GI-PRODIGE Trial.

Clin Colorectal Cancer 2018 Oct 19. Epub 2018 Oct 19.

Sorbonne Paris Cité, Paris Decartes University; Hôpital Européen Georges-Pompidou, Paris, France.

Background: According to the IDEA trial, 6-month adjuvant chemotherapy should remain the treatment standard in stage III T4 or N2 colon cancer. The relatively poor survival in this high-risk subgroup-a 3-year disease-free survival (DFS) rate of 65%-and the potential synergistic efficacy of 5-fluorouracil (5-FU), oxaliplatin, and irinotecan suggest that FOLFIRINOX may be a regimen of particular interest in this setting.

Patients And Methods: This multicenter international phase 3 trial (ClinicalTrials. Read More

View Article
October 2018
4 Reads

A variant of the glucose transporter gene SLC2A2 modifies the glycaemic response to metformin therapy in recently diagnosed type 2 diabetes.

Diabetologia 2018 Nov 9. Epub 2018 Nov 9.

German Center for Diabetes Research (DZD), München-Neuherberg, Germany.

Aims/hypothesis: The aim of this study was to investigate the modifying effect of the glucose transporter (GLUT2) gene SLC2A2 (rs8192675) variant on the glycaemic response to metformin in individuals recently diagnosed with type 2 diabetes.

Methods: Individuals with type 2 diabetes (n = 508) from the prospective German Diabetes Study (age [mean ± SD] 53 ± 10 years; 65% male; BMI 32 ± 6 kg/m, metformin use 57%) underwent detailed metabolic characterisation (hyperinsulinaemic-euglycaemic clamp, IVGTT) during the first year after diagnosis. Participants provided self-reported data from the time of diagnosis. Read More

View Article
November 2018

Neoadjuvant chemotherapy with or without anthracyclines in the presence of dual HER2 blockade for HER2-positive breast cancer (TRAIN-2): a multicentre, open-label, randomised, phase 3 trial.

Lancet Oncol 2018 Dec 6;19(12):1630-1640. Epub 2018 Nov 6.

Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands. Electronic address:

Background: The optimal chemotherapy backbone for dual HER2 blockade in the neoadjuvant setting for early breast cancer is unknown. We investigated whether the addition of anthracyclines would improve pathological complete response compared with a carboplatin-taxane regimen, when given in combination with the HER2-targeted agents trastuzumab and pertuzumab.

Methods: The TRAIN-2 study is an open-label, randomised, controlled, phase 3 trial being done in 37 hospitals in the Netherlands. Read More

View Article
December 2018
5 Reads

Surgical and Functional Outcome after Endoprosthetic Reconstruction in Patients with Osteosarcoma of the Humerus.

Sci Rep 2018 Nov 8;8(1):16148. Epub 2018 Nov 8.

Department of Orthopaedic Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Endoprosthetic reconstruction (EPR) is the most widely used reconstruction technique after humeral osteosarcoma (OSA). Complications are common and function is often compromised due to the premise of wide resection. In the current study we evaluated (1) the risk of complications after resection and EPR; (2) the functional outcome and how it is influenced by the preservation/resection of deltoid muscle (DM), rotator cuff (RC), axillary nerve or the type of resection (intra-/extraarticular) and (3) if the preservation/resection of DM, RC, axillary nerve or the type of resection has a negative influence on the oncological outcome. Read More

View Article
November 2018
4 Reads

Assessment of impact of traffic-related air pollution on morbidity and mortality in Copenhagen Municipality and the health gain of reduced exposure.

Environ Int 2018 Dec 23;121(Pt 1):973-980. Epub 2018 Oct 23.

Faculty of Health Sciences, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Background: Health impact assessment (HIA) of exposure to air pollution is commonly based on city level (fine) particle concentration and may underestimate health consequences of changing local traffic. Exposure to traffic-related air pollution can be assessed at a high resolution by modelling levels of nitrogen dioxide (NO), which together with ultrafine particles mainly originate from diesel-powered vehicles in urban areas. The purpose of this study was to estimate the health benefits of reduced exposure to vehicle emissions assessed as NO at the residence among the citizens of Copenhagen Municipality, Denmark. Read More

View Article
December 2018
4 Reads