1,849 results match your criteria Biometals[Journal]


Exposure routes and health effects of heavy metals on children.

Biometals 2019 Apr 2. Epub 2019 Apr 2.

Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha, 410078, China.

Heavy metals are naturally existing elements that have relatively high atomic weight and a minimum density five times the density of water. Heavy metals have extensive applications in industries, homes, agriculture and medicine, leading to their wide distribution in the environment. Most heavy metals are reported to be highly toxic. Read More

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http://dx.doi.org/10.1007/s10534-019-00193-5DOI Listing
April 2019
15 Reads

The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways.

Authors:
Tracey A Rouault

Biometals 2019 Mar 28. Epub 2019 Mar 28.

National Institutes of Health, Bethesda, MD, 20892, USA.

In recent years, iron sulfur (Fe-S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently recognized roles in RNA and DNA metabolism. Fe-S cofactors have often been missed because of their intrinsic lability and oxygen sensitivity. More Fe-S proteins have now been identified owing to detection of their direct interactions with components of the Fe-S biogenesis machinery, and through use of informatics to detect a motif that binds the co-chaperone responsible for transferring nascent Fe-S clusters to domains of recipient proteins. Read More

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http://link.springer.com/10.1007/s10534-019-00191-7
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http://dx.doi.org/10.1007/s10534-019-00191-7DOI Listing
March 2019
6 Reads

Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics.

Biometals 2019 Mar 27. Epub 2019 Mar 27.

Hsiri Therapeutics, Rosetree Corporate Center, 1400 N. Providence Road, Building 1, Suite 115S, Media, PA, 19063, USA.

New or repurposed antibiotics are desperately needed since bacterial resistance has risen to essentially all of our current antibiotics, and few new antibiotics have been developed over the last several decades. A primary cause of drug resistance is the overuse of antibiotics that can result in alteration of microbial permeability, alteration of drug target binding sites, induction of enzymes that destroy antibiotics (i.e. Read More

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http://dx.doi.org/10.1007/s10534-019-00192-6DOI Listing

Staphylococcus aureus heme and siderophore-iron acquisition pathways.

Biometals 2019 Mar 25. Epub 2019 Mar 25.

Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, V6T 1Z3, Canada.

Staphylococcus aureus is a versatile opportunistic human pathogen. Infection by this bacterium requires uptake of iron from the human host, but iron is highly restricted in this environment. Staphylococcus aureus iron sufficiency is achieved primarily through uptake of heme and high-affinity iron chelators, known as siderophores. Read More

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http://link.springer.com/10.1007/s10534-019-00188-2
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http://dx.doi.org/10.1007/s10534-019-00188-2DOI Listing
March 2019
5 Reads

Synthesis, structural elucidation and antiradical activity of a copper (II) naringenin complex.

Biometals 2019 Mar 25. Epub 2019 Mar 25.

INQUIMAE, CONICET, Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II - Ciudad Universitaria - Núñez, C1428EHA, CABA, Argentina.

Coupling the extraction and derivatization of flavonoids to the Citrus processing industry is attractive from both the environmental and economic points of view. In the present work, the flavonoid naringin, obtained by "green" extraction with a water:ethanol mixture from waste grapefruit industry, was hydrolyzed to obtain naringenin. This flavonoid was used to synthesize the complex trans-di(aqua) bis(7-hydroxy-2-(4-hydroxyphenyl)-4-oxo-5-chromanolato) copper (II). Read More

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http://dx.doi.org/10.1007/s10534-019-00187-3DOI Listing

Looking for a partner: ceruloplasmin in protein-protein interactions.

Authors:
Vadim B Vasilyev

Biometals 2019 04 20;32(2):195-210. Epub 2019 Mar 20.

Institute of Experimental Medicine, 12 Acad. Pavlov Street, Saint Petersburg, Russia, 197376.

Ceruloplasmin (CP) is a mammalian blood plasma ferroxidase. More than 95% of the copper found in plasma is carried by this protein, which is a member of the multicopper oxidase family. Proteins from this group are able to oxidize substrates through the transfer of four electrons to oxygen. Read More

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http://dx.doi.org/10.1007/s10534-019-00189-1DOI Listing
April 2019
1 Read

Molecular structure of thermostable and zinc-ion-binding γ-class carbonic anhydrases.

Biometals 2019 04 20;32(2):317-328. Epub 2019 Mar 20.

Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, China.

The γ-class carbonic anhydrases (γ-CAs) mainly come from methanogens methane-producing bacteria that grow in hot springs and catalyze the interconversion of carbon dioxide and water to bicarbonate and protons. Here, the γ-CA from Thermus thermophilus HB8 (γ-TtCA) was expressed and purified, its crystal structure was determined at 2.3 Å resolution in space group P1. Read More

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http://dx.doi.org/10.1007/s10534-019-00190-8DOI Listing

Assessment of cell-free levels of iron and copper in patients with Friedreich's ataxia.

Biometals 2019 04 14;32(2):307-315. Epub 2019 Mar 14.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India.

Friedreich's ataxia (FRDA), a progressive neurodegenerative disorder caused by trinucleotide (GAA) repeat expansion in frataxin (fxn) gene which results in decreased levels of frataxin protein. Insufficient frataxin levels leads to iron and copper deposits in the brain and cardiac cells. A total of hundred and twenty patients, suspected of FRDA were screened for the (GAA) repeats in the fxn gene and only confirmed patients (n = 25) were recruited in the study. Read More

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http://dx.doi.org/10.1007/s10534-019-00186-4DOI Listing
April 2019
1 Read

Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography.

Biometals 2019 04 7;32(2):293-306. Epub 2019 Mar 7.

School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.

Niemann-Pick C disease (NPC) is an autosomal recessive lysosomal storage disorder resulting from mutations in the NPC1 (95% of cases) or NPC2 genes. Disturbance of copper homeostasis has been reported in NPC1 disease. In this study we have used whole-body positron emission tomography (PET) and brain electronic autoradiography with copper-64 (Cu), in the form of the copper(II) bis(thiosemicarbazonato) complex Cu-GTSM, to image short-term changes in copper trafficking after intravenous injection in a transgenic mouse model of NPC1 disease. Read More

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http://dx.doi.org/10.1007/s10534-019-00185-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437134PMC
April 2019
1 Read
2.503 Impact Factor

Highly conserved nucleotide motifs present in the 5'UTR of the heme-receptor gene shmR are required for HmuP-dependent expression of shmR in Ensifer meliloti.

Biometals 2019 04 27;32(2):273-291. Epub 2019 Feb 27.

Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay.

Heme may represent a major iron-source for bacteria. In the symbiotic nitrogen-fixing bacterium Ensifer meliloti 1021, iron acquisition from heme depends on the outer-membrane heme-receptor ShmR. Expression of shmR gene is repressed by iron in a RirA dependent manner while under iron-limitation its expression requires the small protein HmuP. Read More

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http://dx.doi.org/10.1007/s10534-019-00184-6DOI Listing

The anti-bacterial iron-restriction defence mechanisms of egg white; the potential role of three lipocalin-like proteins in resistance against Salmonella.

Biometals 2019 Feb 27. Epub 2019 Feb 27.

School of Biological Sciences, University of Reading, Reading, RG6 6UA, UK.

Salmonella enterica serovar Enteritidis (SE) is the most frequently-detected Salmonella in foodborne outbreaks in the European Union. Among such outbreaks, egg and egg products were identified as the most common vehicles of infection. Possibly, the major antibacterial property of egg white is iron restriction, which results from the presence of the iron-binding protein, ovotransferrin. Read More

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http://dx.doi.org/10.1007/s10534-019-00180-wDOI Listing
February 2019
1 Read

Iron uptake by ZIP8 and ZIP14 in human proximal tubular epithelial cells.

Biometals 2019 04 26;32(2):211-226. Epub 2019 Feb 26.

Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

In patients with iron overload disorders, increasing number of reports of renal dysfunction and renal iron deposition support an association between increased iron exposure and renal injury. In systemic iron overload, elevated circulating levels of transferrin-bound (TBI) and non-transferrin-bound iron (NTBI) are filtered to the renal proximal tubules, where they may cause injury. However, the mechanisms of tubular iron handling remain elusive. Read More

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http://dx.doi.org/10.1007/s10534-019-00183-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437295PMC

Dietary iron absorption during early postnatal life.

Biometals 2019 Feb 23. Epub 2019 Feb 23.

Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD, 4006, Australia.

Inadequate iron levels during early life can have adverse consequences for the developing infant. Iron deficiency during this critical period of growth can affect brain development and cognitive function, problems that can be lifelong despite subsequent correction of the iron deficit. Therefore, it is critical that the suckling infant has sufficient iron for their developmental needs. Read More

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http://dx.doi.org/10.1007/s10534-019-00181-9DOI Listing
February 2019

Transition metals and host-microbe interactions in the inflamed intestine.

Biometals 2019 Feb 20. Epub 2019 Feb 20.

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Host-associated microbial communities provide critical functions for their hosts. Transition metals are essential for both the mammalian host and the majority of commensal bacteria. As such, access to transition metals is an important component of host-microbe interactions in the gastrointestinal tract. Read More

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http://dx.doi.org/10.1007/s10534-019-00182-8DOI Listing
February 2019

Complex formation between the Escherichia coli [NiFe]-hydrogenase nickel maturation factors.

Biometals 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.

The biosynthesis of the dinuclear metal cluster at the active sites of the [NiFe]-hydrogenase enzymes is a multi-step process executed by a suite of accessory proteins. Nickel insertion during maturation of Escherichia coli [NiFe]-hydrogenase 3 is achieved by the metallochaperones HypA, SlyD and the GTPase HypB, but how these proteins cooperate to ensure nickel delivery is not known. In this study, the complexes formed between the individual purified proteins were examined by using several methods. Read More

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http://dx.doi.org/10.1007/s10534-019-00173-9DOI Listing
February 2019

An engineered GFP fluorescent bacterial biosensor for detecting and quantifying silver and copper ions.

Biometals 2019 04 13;32(2):265-272. Epub 2019 Feb 13.

Department of Biology, University of Waterloo, Waterloo, ON, Canada.

Presented here are two engineered bacterial biosensors for detecting and quantifying silver and copper ions. The biosensors contain a silver/copper resistance operon and a Green Fluorescent Protein gene that is strictly regulated through silver activated promoter regions normally found on a silver resistance gene (sil operon). The two biosensors efficiently detected silver and copper concentrations of 40 µM-300 µM and 20 µM-600 µM respectively. Read More

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http://link.springer.com/10.1007/s10534-019-00179-3
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http://dx.doi.org/10.1007/s10534-019-00179-3DOI Listing
April 2019
15 Reads

An H-ferritin from the hydrothermal vent shrimp Rimicaris exoculata and its potential role in iron metabolism.

Biometals 2019 04 12;32(2):251-264. Epub 2019 Feb 12.

College of Life Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, People's Republic of China.

Rimicaris exoculata (Decapoda: Bresiliidae) is one of the dominant species among hydrothermal vent communities along the Mid-Atlantic Ridge. This shrimp can tolerate high concentrations of heavy metals such as iron, but the mechanisms used for detoxification and utilization of excess metals remain largely unknown. Ferritin is a major iron storage protein in most living organisms. Read More

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http://dx.doi.org/10.1007/s10534-019-00174-8DOI Listing
April 2019
2 Reads

Profiling of nuclear copper-binding proteins under hypoxic condition.

Biometals 2019 04 9;32(2):329-341. Epub 2019 Feb 9.

Regenerative Medicine Research Center, Sichuan University West China Hospital, Chengdu, 610041, Sichuan, China.

Under hypoxic condition, copper (Cu) accumulates in cell nuclei, and regulates the activity of hypoxia-inducible factor-1 (HIF-1) through Cu-binding proteins (CuBPs). To understand the CuBPs in the nucleus, proteomic approach was undertaken to explore the dynamic changes of the CuBPs in response to hypoxia. Human umbilical vein endothelial cells (HUVECs) were treated with dimethyloxalylglycine in a final concentration of 100 μM for 4 h to induce hypoxia, resulting in the accumulation of HIF-1α and Cu in the nucleus. Read More

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http://link.springer.com/10.1007/s10534-019-00171-x
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http://dx.doi.org/10.1007/s10534-019-00171-xDOI Listing
April 2019
9 Reads

Purification and characterization of Campylobacter jejuni ferric uptake regulator.

Biometals 2019 Jan 31. Epub 2019 Jan 31.

Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Roger Guindon Hall, Ottawa, ON, K1H 8M5, Canada.

The ferric uptake regulator (Fur) is a superfamily of transcription factors found in bacteria which control the expression of a myriad of genes. In this study, we report a simple protocol for the purification of recombinant untagged Campylobacter jejuni Fur (CjFur). CjFur was isolated using a combination of three ion exchange chromatography steps followed by size exclusion chromatography on a Superdex 75. Read More

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http://dx.doi.org/10.1007/s10534-019-00177-5DOI Listing
January 2019

Analogues of desferrioxamine B (DFOB) with new properties and new functions generated using precursor-directed biosynthesis.

Biometals 2019 Jan 30. Epub 2019 Jan 30.

School of Medical Sciences (Pharmacology), The University of Sydney, Sydney, NSW, 2006, Australia.

Desferrioxamine B (DFOB) is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. Although DFOB has a long clinical history for the treatment of chronic iron overload, limitations encourage the development of new analogues. This review describes a recent body of work that has used precursor-directed biosynthesis (PDB) to access new DFOB analogues. Read More

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http://dx.doi.org/10.1007/s10534-019-00175-7DOI Listing
January 2019

Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts.

Biometals 2019 Jan 30. Epub 2019 Jan 30.

Department of Physiology, Pathophysiology & Toxicology and ZBAF (Centre for Biomedical Education and Research), Faculty of Health, School of Medicine, Witten/Herdecke University, Stockumer Str 12 (Thyssenhaus), 58453, Witten, Germany.

Cadmium (Cd) is a toxic and non-essential divalent metal ion in eukaryotic cells. Cells can only be targeted by Cd if it hijacks physiological high-affinity entry pathways, which transport essential divalent metal ions in a process termed "ionic and molecular mimicry". Hence, "free" Cd ions and Cd complexed with small organic molecules are transported across cellular membranes via ion channels, carriers and ATP hydrolyzing pumps, whereas receptor-mediated endocytosis (RME) internalizes Cd-protein complexes. Read More

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http://dx.doi.org/10.1007/s10534-019-00176-6DOI Listing
January 2019
5 Reads

Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes.

Biometals 2019 02 22;32(1):123-138. Epub 2019 Jan 22.

School of Medicine, University of St Andrews, Medical and Biological Sciences Building, St Andrews, Fife, KY16 9TF, UK.

Glycemia and insulin resistance are important regulators of multiple physiological processes and their dysregulation has wide-ranging consequences, including alterations in plasma concentrations of metal micronutrients. Here, magnesium, zinc, copper, selenium and glycated albumin (HbA1c) concentrations and quartile differences were examined in 45 subjects with type-I diabetes (T1DM), 54 subjects with type-II diabetes (T2DM) and 62 control subjects in order to assess potential differences between sexes and between T1DM and T2DM. Plasma magnesium concentration was decreased in T1DM subjects, with the second, third and fourth quartiles of magnesium concentrations associated with the absence of T1DM. Read More

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http://dx.doi.org/10.1007/s10534-018-00167-zDOI Listing
February 2019

DNA cleavage, DNA/HSA binding study, and antiproliferative activity of a phenolate-bridged binuclear copper(II) complex.

Biometals 2019 04 18;32(2):227-240. Epub 2019 Jan 18.

Flexible Display Materials & Technology, Co-Innovation Center of Hubei, Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Chemistry and Environmental Engineering, Jianghan University, Wuhan, 430056, People's Republic of China.

A novel phenolate-bridged binuclear copper(II) complex, [Cu (L-3H)Cl] (1, where L = 2,6-bis[((2-hydroxybenzyl)(2-pyridylmethyl)amino)methyl]-4-methylphenol), have been synthesized and characterized. The antiproliferative activity of the complex has been tested in vitro against the human cervical cancer cell line HeLa, human non-small-cell lung cancer cell line A-549, the human breast cancer cell line MCF-7, and the human hepatic cell line LO2. The results show the complex has the low micromolar range (9. Read More

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http://dx.doi.org/10.1007/s10534-019-00172-wDOI Listing
April 2019
1 Read

Biodegradable magnesium alloys as temporary orthopaedic implants: a review.

Biometals 2019 04 18;32(2):185-193. Epub 2019 Jan 18.

Technische Universität Berlin, Berlin, Germany.

The study of innovative biodegradable implant materials is one of the most interesting research topics at the forefront in the area of biomaterials. Biodegradable implant materials in the human body can be gradually dissolved, absorbed, consumed or excreted, so there is no need for the secondary surgery to remove implants after the surgery regions have healed. However, most of the biodegradable materials, usually polymers, do not have good mechanical properties to be reliable for bearing the load of the body. Read More

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http://dx.doi.org/10.1007/s10534-019-00170-yDOI Listing

The bioaccumulation of waterborne zinc in tissues of silver catfish (Rhamdia quelen) and its effect on biochemical parameters.

Biometals 2019 04 16;32(2):241-249. Epub 2019 Jan 16.

Programa de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil.

Silver catfish (Rhamdia quelen) is a fish species with neotropical distribution, and is a potential model organism to study polluted environment. The aim of this study is to analyze the response of silver catfish to environmental concentrations of waterborne zinc (Zn) over 96 h. Significant metal accumulation was seen in gill, intestine and liver tissues. Read More

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http://dx.doi.org/10.1007/s10534-019-00168-6DOI Listing

Determination of iron species, including biomineralized jarosite, in the iron-hyperaccumulator moss Scopelophila ligulata by Mössbauer, X-ray diffraction, and elemental analyses.

Biometals 2019 02 12;32(1):171-184. Epub 2019 Jan 12.

Graduate School of Environment and Information Sciences, Yokohama National University, Tokiwadai 79-7, Hodogayaku, Yokohama, 240-8501, Japan.

Scopelophila ligulata is an Fe-hyperaccumulator moss growing in acidic environments, but the mechanism of Fe accumulation remains unknown. To understand the mechanism, we determined Fe species in S. ligulata samples. Read More

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http://dx.doi.org/10.1007/s10534-019-00169-5DOI Listing
February 2019
1 Read

Complexes formed by the siderophore-based monosulfactam antibiotic BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa.

Biometals 2019 02 11;32(1):155-170. Epub 2019 Jan 11.

Department of Physics, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. 8 km 0.700, 09042, Monserrato, CA, Italy.

Nuclear magnetic resonance and infrared spectroscopy have been used to investigate the formation of complexes of BAL30072 with Fe and Ga in solution and to collect geometrical parameters supporting reliable 3D structure models. Structural models for the ligand-metal complexes with different stoichiometries have been characterized using density functional theory calculations. Blind ensemble docking to the PiuA receptor from P. Read More

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http://link.springer.com/10.1007/s10534-018-00166-0
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http://dx.doi.org/10.1007/s10534-018-00166-0DOI Listing
February 2019
20 Reads

Distribution of dissolved iron and bacteria producing the photoactive siderophore, vibrioferrin, in waters off Southern California and Northern Baja.

Biometals 2019 02 8;32(1):139-154. Epub 2019 Jan 8.

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, 92182-1030, USA.

Phytoplankton blooms can cause acute effects on marine ecosystems due either to their production of endogenous toxins or to their enormous biomass leading to major impacts on local economies and public health. Despite years of effort, the causes of these Harmful Algal Blooms are still not fully understood. Our hypothesis is that bacteria that produce photoactive siderophores may provide a bioavailable source of iron for phytoplankton which could in turn stimulate algal growth and support bloom dynamics. Read More

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http://dx.doi.org/10.1007/s10534-018-00163-3DOI Listing
February 2019
2.503 Impact Factor

MiRNA-target interactions in osteogenic signaling pathways involving zinc via the metal regulatory element.

Biometals 2019 02 18;32(1):111-121. Epub 2018 Dec 18.

Department of Foods and Nutrition, University of Georgia, Athens, GA, USA.

Adequate zinc nutriture is necessary for normal bone growth and development, though the precise mechanisms for zinc-mediated bone growth remain poorly defined. A key transcription factor activated by zinc is metal response element-binding transcription factor 1 (MTF-1), which binds to the metal regulatory element (MRE). We hypothesize that MREs will be found upstream of miRNA genes as well as miRNA target genes in the following bone growth and development signaling pathways: TGF-β, MAPK, and Wnt. Read More

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http://dx.doi.org/10.1007/s10534-018-00162-4DOI Listing
February 2019
1 Read

Cadmium induced glutathione bioaccumulation mediated by γ-glutamylcysteine synthetase in ectomycorrhizal fungus Hebeloma cylindrosporum.

Biometals 2019 02 17;32(1):101-110. Epub 2018 Dec 17.

Department of Biotechnology, Thapar Institute of Engineering & Technology, Bhadson Road, Patiala, Punjab, 147004, India.

Ectomycorrhizal fungi hold a potential role in bioremediation of heavy metal polluted areas because of its metal accumulation and detoxification property. We investigated the cadmium (Cd) induced bioaccumulation of glutathione (GSH) mediated by γ-glutamylcysteine synthetase (γ-GCS) in the ectomycorrhizal fungus Hebeloma cylindrosporum. In H. Read More

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http://dx.doi.org/10.1007/s10534-018-00164-2DOI Listing
February 2019

Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors.

Biometals 2019 02 30;32(1):89-100. Epub 2018 Nov 30.

Center of Exact Sciences and Technology, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.

Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anticancer agents. Previous studies showed that three ruthenium(II) compounds: [Ru(pySH)(bipy)(dppb)]PF (1), [Ru(HSpym)(bipy)(dppb)]PF (2) and Ru[(SpymMe)(bipy)(dppb)]PF (3) presented anticancer properties higher than doxorubicin and cisplatin and acted as human topoisomerase IB (Topo I) inhibitors. Here, we focused our studies on in vitro intestinal permeability and anticancer mechanisms of these three complexes. Read More

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http://dx.doi.org/10.1007/s10534-018-0160-0DOI Listing
February 2019

Algae induce siderophore biosynthesis in the freshwater bacterium Cupriavidus necator H16.

Biometals 2019 02 24;32(1):77-88. Epub 2018 Nov 24.

Laboratory of Technical Biology, Department of Biochemical and Chemical Engineering, TU Dortmund University, Emil-Figge-Strasse 66, 44227, Dortmund, Germany.

Cupriachelin is a photoreactive lipopeptide siderophore produced by the freshwater bacterium Cupriavidus necator H16. In the presence of sunlight, the iron-loaded siderophore undergoes photolytic cleavage, thereby releasing solubilized iron into the environment. This iron is not only available to the siderophore producer, but also to the surrounding microbial community. Read More

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http://link.springer.com/10.1007/s10534-018-0159-6
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http://dx.doi.org/10.1007/s10534-018-0159-6DOI Listing
February 2019
12 Reads

Arsenite biotransformation and bioaccumulation by Klebsiella pneumoniae strain SSSW7 possessing arsenite oxidase (aioA) gene.

Biometals 2019 02 23;32(1):65-76. Epub 2018 Nov 23.

Center of Advanced Study in Botany, Banaras Hindu University, Varanasi, U.P., 221005, India.

Arsenite oxidizing Klebsiella pneumoniae strain SSSW7 isolated from shipyard waste Goa, India showed a minimum inhibitory concentration of 21 mM in mineral salts medium. The strain possessed a small supercoiled plasmid and PCR amplification of arsenite oxidase gene (aioA) was observed on plasmid as well as chromosomal DNA. It was confirmed that arsenite oxidase enzyme was a periplasmic protein with a 47% increase in arsenite oxidase activity at 1 mM sodium arsenite. Read More

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http://dx.doi.org/10.1007/s10534-018-0158-7DOI Listing
February 2019
4 Reads

Altered drug efflux under iron deprivation unveils abrogated MmpL3 driven mycolic acid transport and fluidity in mycobacteria.

Biometals 2019 02 15;32(1):49-63. Epub 2018 Nov 15.

Amity Institute of Biotechnology, Amity University Haryana, Gurugram, Manesar, 122413, India.

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is a global threat to human health hence better understanding of the MTB pathogenesis for improved therapeutics requires immediate attention. Emergence of drug-resistant strains has stimulated an urgent need for adopting new strategies that could be implemented to control TB. One of the contributing mechanisms by which MTB evades drug doses is overexpression of drug efflux pumps. Read More

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http://link.springer.com/10.1007/s10534-018-0157-8
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http://dx.doi.org/10.1007/s10534-018-0157-8DOI Listing
February 2019
18 Reads

Role of nitric oxide and hydrogen sulfide in plant aluminum tolerance.

Biometals 2019 02 1;32(1):1-9. Epub 2018 Nov 1.

College of Agronomy, Guangxi University, Nanning, 530004, China.

As gasotransmitter, nitric oxide (NO) and hydrogen sulfide (HS) are involved in the regulation of plant tolerance to abiotic stresses. Aluminum (Al) toxicity triggers synthesis of NO and HS and seriously affects plant growth and productivity. Exogenous NO and HS alleviate Al toxicity in plants. Read More

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http://link.springer.com/10.1007/s10534-018-0156-9
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http://dx.doi.org/10.1007/s10534-018-0156-9DOI Listing
February 2019
3 Reads

New platinum(II) and palladium(II) complexes with substituted terpyridine ligands: synthesis and characterization, cytotoxicity and reactivity towards biomolecules.

Biometals 2019 02 26;32(1):33-47. Epub 2018 Oct 26.

Department of Chemistry, XStruct, Ghent University, 9000, Ghent, Belgium.

A series of palladium(II) (1-3) and platinum(II) chloride complexes (4 and 5) with 2,2':6',2″-terpyridine (terpy) derivatives substituted at the 4' position, was synthesized and fully characterized. Single crystal X-ray diffraction analysis of complexes 2, 3 and 5 showed tridentate coordination of the 4'-substituted terpyridine (terpy) ligands to the metal center. Moreover, in vitro cytotoxic activity of these complexes toward a panel of human cancer cell lines (lung cancer A549, colorectal cancer HCT116, ovarian cancer IGROV-1) and toward normal cell line HDF (dermal fibroblast) was determined by Trypan Blue exclusion assay. Read More

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http://link.springer.com/10.1007/s10534-018-0155-x
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http://dx.doi.org/10.1007/s10534-018-0155-xDOI Listing
February 2019
21 Reads

Copper complex with sulfamethazine and 2,2'-bipyridine supported on mesoporous silica microspheres improves its antitumor action toward human osteosarcoma cells: cyto- and genotoxic effects.

Biometals 2019 02 17;32(1):21-32. Epub 2018 Oct 17.

CEQUINOR (CONICET-UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900, La Plata, Argentina.

Ideal drugs to cure cancer leave normal cells unharmed while selectively turning tumor cells unviable. Several copper complexes have been able to selectively slow down tumor proliferation. We hypothesized that Cu(smz)(bipy)·HO (1)-a copper-complex that has two ligands capable of interacting with DNA-would outperform Cu(smz)(OH)·2HO (2), and also that supporting 1 on mesoporous silica spheres would decrease even further tumor cell viability in vitro. Read More

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http://dx.doi.org/10.1007/s10534-018-0154-yDOI Listing
February 2019
2 Reads

Nickel and cobalt affect galactosylation of recombinant IgG expressed in CHO cells.

Biometals 2019 02 16;32(1):11-19. Epub 2018 Oct 16.

Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune, 411008, India.

Glycosylation is an important product quality attribute of antibody biopharmaceuticals. It involves enzymatic addition of oligosaccharides on proteins by sequential action of glycosyltransferases and glycosidases in the endoplasmic reticulum and golgi. Some of these enzymes like galactosyltransferase and N-acetylglucosaminyltransferase-I require trace metal cofactors. Read More

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http://link.springer.com/10.1007/s10534-018-0152-0
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http://dx.doi.org/10.1007/s10534-018-0152-0DOI Listing
February 2019
16 Reads

Physicochemical characterization of ferric pyrophosphate citrate.

Biometals 2018 12 15;31(6):1091-1099. Epub 2018 Oct 15.

Physics Department, Illinois Institute of Technology, Chicago, IL, USA.

Iron deficiency is a significant health problem across the world. While many patients benefit from oral iron supplements, some, including those on hemodialysis require intravenous iron therapy to maintain adequate iron levels. Until recently, all iron compounds suitable for parenteral administration were colloidal iron-carbohydrate conjugates that require uptake and processing by macrophages. Read More

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http://link.springer.com/10.1007/s10534-018-0151-1
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http://dx.doi.org/10.1007/s10534-018-0151-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245090PMC
December 2018
28 Reads

Protective effect of tea against lead and cadmium-induced oxidative stress-a review.

Biometals 2018 12 13;31(6):909-926. Epub 2018 Oct 13.

Department of Bromatology and Food Physiology, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland.

Exposure to Cd and Pb reduces the activity of antioxidant enzymes, which points to a decrease in the antioxidant potential of the body as a result of supplying factors which enhance cellular oxidation processes. Man is exposed to the effects of toxic metals because they are present in the environment, including in food. Since no effective ways to reduce the concentrations of Cd an Pb in food exist, studies are undertaken to develop methods of reducing their toxic effect on the body through chelating these metals using nutrients (which reduces their absorption by tissues) or increasing the oxidative capacity of the body (which decreases the possibility of inducing oxidative damage to internal organs). Read More

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http://link.springer.com/10.1007/s10534-018-0153-z
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http://dx.doi.org/10.1007/s10534-018-0153-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245044PMC
December 2018
3 Reads

Studies on the activation of isocitrate dehydrogenase kinase/phosphatase (AceK) by Mn and Mg.

Biometals 2018 12 12;31(6):991-1002. Epub 2018 Oct 12.

Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing, 100875, People's Republic of China.

Isocitrate dehydrogenase kinase/phosphatase (AceK) is a bifunctional enzyme with both kinase and phosphatase activities that are activated by Mg. We have studied the interactions of Mnand Mg with AceK using isothermal titration calorimetry (ITC) combined with molecular docking simulations and show for the first time that Mn also activates the enzyme activities. However, Mn and Mg exert their effects by different mechanisms. Read More

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http://link.springer.com/10.1007/s10534-018-0144-0
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December 2018
1 Read

Ferric pyrophosphate citrate: interactions with transferrin.

Biometals 2018 12 11;31(6):1081-1089. Epub 2018 Oct 11.

Rockwell Medical, Wixom, MI, USA.

There are several options available for intravenous application of iron supplements, but they all have a similar structure:-an iron core surrounded by a carbohydrate coating. These nanoparticles require processing by the reticuloendothelial system to release iron, which is subsequently picked up by the iron-binding protein transferrin and distributed throughout the body, with most of the iron supplied to the bone marrow. This process risks exposing cells and tissues to free iron, which is potentially toxic due to its high redox activity. Read More

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http://link.springer.com/10.1007/s10534-018-0142-2
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http://dx.doi.org/10.1007/s10534-018-0142-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245029PMC
December 2018
4 Reads

Aging results in iron accumulations in the non-human primate choroid of the eye without an associated increase in zinc, copper or sulphur.

Biometals 2018 12 10;31(6):1061-1073. Epub 2018 Oct 10.

UCL Institute of Ophthalmology, 11-43 Bath St, London, EC1V 9EL, UK.

We present further analyses of a previous experiment published in 2016 where the distribution, concentration and correlation of iron, zinc, copper and sulphur in the choroid of the eye in young and aged old world primates (Macaca fascicularis) was studied with synchrotron X-ray fluorescence with a 2 μm resolution. The results indicate that iron accumulates in hotspots in the choroid with age with fluorescence intensity ranging from 2- to 7-fold (1002-3752 ppm) the mean level in the choroidal stroma (500 ppm) and maximum iron levels in blood vessel lumina. Iron hotspots with iron ppm > 1000 preferentially contained Fe as demonstrated by Perls staining. Read More

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http://link.springer.com/10.1007/s10534-018-0147-x
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http://dx.doi.org/10.1007/s10534-018-0147-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245114PMC
December 2018
1 Read

The effects of the timing of exposure to cadmium on the oviposition behavior of Drosophila melanogaster.

Biometals 2018 12 8;31(6):1075-1080. Epub 2018 Oct 8.

Department of Biology, Loras College, Dubuque, IA, USA.

Animals can greatly increase their fitness by choosing oviposition sites free from damaging substances such as the heavy metal cadmium (Cd). Previous research has shown that Drosophila melanogaster reared on uncontaminated media lay fewer eggs on substrates containing Cd. In this study, we examined the effects of prior exposure to Cd on oviposition site preference. Read More

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http://dx.doi.org/10.1007/s10534-018-0148-9DOI Listing
December 2018

Citrate analysis using capillary electrophoresis and complexation with Eu-tetracycline.

Biometals 2018 12 5;31(6):1043-1049. Epub 2018 Oct 5.

Department of Chemistry, University of Winnipeg, 599 Portage Avenue, Winnipeg, MB, R3B 2G3, Canada.

A sensitive assay for citrate was developed. Citrate was incubated with 50 μM Eu-tetracycline and the complex separated using capillary electrophoresis utilizing post-column laser-induced luminescence detection in a sheath flow cuvette. Signal was linear with citrate concentration from 10 μM to 200 nM. Read More

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http://dx.doi.org/10.1007/s10534-018-0149-8DOI Listing
December 2018

Selenium-Rich Yeast protects against aluminum-induced peroxidation of lipide and inflammation in mice liver.

Biometals 2018 12 4;31(6):1051-1059. Epub 2018 Oct 4.

College of Science and Engineering, Foshan University, Foshan, 528231, Guangdong, People's Republic of China.

To investigate the effect of Selenium Rich Yeast (SeY) on hepatotoxicity of Aluminium (Al), SeY (0.1 mg/kg) was orally administrated to aluminium-exposed mice (10 mg/kg) for 28 days. The risk of oxidative stress was assessed by detecting the total antioxidant capacity (T-AOC), catalase activity, HO content, and mRNA levels of the Keap1/Nrf-2/HO-1 pathway. Read More

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http://link.springer.com/10.1007/s10534-018-0150-2
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December 2018
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Genome-wide exploration of C2H2 zinc finger family in durum wheat (Triticum turgidum ssp. Durum): insights into the roles in biological processes especially stress response.

Biometals 2018 12 4;31(6):1019-1042. Epub 2018 Oct 4.

Department of Plant Breeding, Faculty of Crop Science, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran.

C2H2 type of zinc finger transcription factors (C2H2-ZFP TFs) play crucial roles in plant developments and stress response. Regarding its importance, genome-wide study of C2H2-ZFs were performed in multiple important plant species, but any such investigation was not fulfilled in Triticum turgidum ssp. Durum (durum wheat) as an important nutritional crop. Read More

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http://dx.doi.org/10.1007/s10534-018-0146-yDOI Listing
December 2018
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Chromosomal Sil system contributes to silver resistance in E. coli ATCC 8739.

Biometals 2018 12 4;31(6):1101-1114. Epub 2018 Oct 4.

Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, 8092, Zurich, Switzerland.

The rise of antibiotic resistance in pathogenic bacteria is endangering the efficacy of antibiotics, which consequently results in greater use of silver as a biocide. Chromosomal mapping of the Cus system or plasmid encoded Sil system and their relationship with silver resistance was studied for several gram-negative bacteria. However, only few reports investigated silver detoxification mediated by the Sil system integrated in Escherichia coli chromosome. Read More

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http://link.springer.com/10.1007/s10534-018-0143-1
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http://dx.doi.org/10.1007/s10534-018-0143-1DOI Listing
December 2018
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In vitro leishmanicidal activity and theoretical insights into biological action of ruthenium(II) organometallic complexes containing anti-inflammatories.

Biometals 2018 12 4;31(6):1003-1017. Epub 2018 Oct 4.

Instituto de Química, Universidade Federal de Uberlândia, Av. João Naves de Ávila, 2121, Uberlândia, MG, 38408-100, Brazil.

Leishmaniasis, a neglected tropical disease caused by protozoans of the genus Leishmania, kills around 20-30 thousand people in Africa, Asia, and Latin America annually and, despite its potential lethality, it can be treated and eventually cured. However, the current treatments are limited owing to severe side effects and resistance development by some Leishmania. These factors make it urgent to develop new leishmanicidal drugs. Read More

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http://dx.doi.org/10.1007/s10534-018-0145-zDOI Listing
December 2018
18 Reads

Silver in the meat and organs of broiler chickens in case of using colloidal silver as an alternative to antibiotics.

Biometals 2018 12 3;31(6):975-980. Epub 2018 Oct 3.

Institute of Molecular Biology and Biophysics - subdivision of FRC FTM, Novosibirsk, Russia.

The search for new antibacterial products, the mechanisms of action of which differ from conventional antibiotics is a current a topical issue. The objective of our research is to identify the presence of silver in meat and organs of broiler chicks that had been given colloidal silver. The results show that the broiler chick meat contains silver in quantities safe for humans regardless of the use of colloidal silver. Read More

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http://link.springer.com/10.1007/s10534-018-0141-3
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http://dx.doi.org/10.1007/s10534-018-0141-3DOI Listing
December 2018
5 Reads