1,894 results match your criteria Biometals[Journal]


Siderophores in plant root tissue: Tagetes patula nana colonized by the arbuscular mycorrhizal fungus Gigaspora margarita.

Biometals 2020 May 3. Epub 2020 May 3.

Department of Microbiology & Biotechnology, University of Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany.

More than 70% of vascular plant species live in symbiosis with arbuscular mycorrhizal (AM) fungi. In addition to other effects this symbiosis is known for its significance for plant nutrition including iron. Fungal iron mobilization from soil is commonly dependent on siderophores. Read More

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http://dx.doi.org/10.1007/s10534-020-00238-0DOI Listing

The role of apoptosis and autophagy in the insulin-enhancing activity of oxovanadium(IV) bipyridine complex in streptozotocin-induced diabetic mice.

Biometals 2020 Apr 21. Epub 2020 Apr 21.

Biochemistry Department, Faculty of Science, Damietta University, New Damietta, Egypt.

Metal-based therapies (e.g. Vanadium) possess an attractive proposition in medicinal treatment of diabetes mellitus. Read More

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http://dx.doi.org/10.1007/s10534-020-00237-1DOI Listing

Influence of oral administration mode on the efficacy of commercial bovine Lactoferrin against iron and inflammatory homeostasis disorders.

Biometals 2020 Apr 9. Epub 2020 Apr 9.

Department of Public Health and Infectious Diseases, University of Rome, La Sapienza, 00185, Rome, Italy.

Milk derivative bovine Lactoferrin (bLf), a multifunctional glycoprotein available in large quantities and recognized as safe, possesses high homology and identical functions with human Lactoferrin. There are numerous food supplements containing bLf which, however, can vary in its purity, integrity and, consequently, functionality. Here, we report on a clinical trial where bLf (100 mg two times/day) was orally administered before (Arm A) or during meals (Arm B) to pregnant women with hereditary thrombophilia and suffering from anemia of inflammation. Read More

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http://dx.doi.org/10.1007/s10534-020-00236-2DOI Listing

New cyclometalated gold (III) complex targeting thioredoxin reductase: exploring as cytotoxic agents and mechanistic insights.

Biometals 2020 Apr 3. Epub 2020 Apr 3.

School of Chemistry, National University of Ireland, Galway, University Road, Galway, H91 TK33, Ireland.

A new cyclometalated Au(III) complex highlighting a naphthoquinone-C^N scaffold with formula (NQ-N^C)Au(SAd)Cl, 1, in which NQ-N^C: 2-(5-amino-benzo[h]quinolone)-3-(3-methyl-2-butenyl)-1,4-naphthoquinone, HSAd: 1-adamantanethiol, was synthesized and characterized. The interaction of complex 1 with cysteine (CysH) was experimentally and theoretically studied. Complex 1 was more active against MCF-7 and A549 cancer cell lines and less active in a healthy cell (non-tumorigenic cells, MRC-5) than cisplatin. Read More

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http://dx.doi.org/10.1007/s10534-020-00235-3DOI Listing

Differential effects of Cu and Fe ions on in vitro amyloid formation of biologically-relevant α-synuclein variants.

Biometals 2020 Mar 13. Epub 2020 Mar 13.

Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.

Alterations in metal ion homeostasis appear coupled to neurodegenerative disorders but mechanisms are unknown. Amyloid formation of the protein α-synuclein in brain cells is a hallmark of Parkinson's disease. α-Synuclein can bind several metal ions in vitro and such interactions may affect the assembly process. Read More

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http://dx.doi.org/10.1007/s10534-020-00234-4DOI Listing
March 2020
2.503 Impact Factor

Iron chelation by deferiprone does not rescue the Niemann-Pick Disease Type C1 mouse model.

Biometals 2020 Feb 25. Epub 2020 Feb 25.

Oxidation Biology Unit, Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Melbourne, VIC, 3052, Australia.

Niemann-Pick Disease Type C (NP-C) is a fatal lysosomal storage disorder with progressive neurodegeneration. In addition to the characteristic cholesterol and lipid overload phenotype, we previously found that altered metal homeostasis is also a pathological feature. Increased brain iron in the Npc1 mouse model of NP-C may potentially contribute to neurodegeneration, similar to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Read More

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http://dx.doi.org/10.1007/s10534-020-00233-5DOI Listing
February 2020

Iron-oxide minerals in the human tissues.

Biometals 2020 02 22;33(1):1-13. Epub 2020 Jan 22.

Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08, Bratislava, Slovakia.

Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic; therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Read More

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http://dx.doi.org/10.1007/s10534-020-00232-6DOI Listing
February 2020

Zinc gluconate supplementation impacts the clinical improvement in patients with ulcerative colitis.

Biometals 2020 02 19;33(1):15-27. Epub 2020 Jan 19.

Department of Nutrition, Federal University of Piauí, Teresina, Piauí, Brazil.

Ulcerative colitis is an inflammatory bowel disease that affects the mucous membrane of the colon. The pathogenesis is not clear, but there is evidence of a complex interaction between genetic, environmental, and immunological factors. In this regard, we highlight the role of zinc in the immune system and probable control of the disease. Read More

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http://dx.doi.org/10.1007/s10534-019-00225-0DOI Listing
February 2020

Estimation and in-situ detection of thorium in human liver cell culture by arsenazo-III based colorimetric assay.

Biometals 2020 02 2;33(1):75-85. Epub 2020 Jan 2.

Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India.

To understand the biological effects of Thorium-232 (Th) in human cells and animal models as well as to assess mitigation strategies for its detoxification, there is a need to develop a sensitive, specific, high-throughput and easily-implementable assay for detection and estimation of Th in biological samples. Here, we have optimized arsenazo-III dye based colorimetric assay to detect Th in biological samples. The concentration of arsenazo-III (i. Read More

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http://dx.doi.org/10.1007/s10534-019-00231-2DOI Listing
February 2020
2.503 Impact Factor

Quantitative proteomic analysis reveals that the Rap1/MAPK/ERK pathway is inhibited through selenomethionine strengthening antioxidant activity.

Biometals 2020 02 13;33(1):45-64. Epub 2019 Dec 13.

College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing High-Tech Industrial Development Zone, Daqing, 163319, Heilongjiang, People's Republic of China.

To investigate the influence on the proteome of chicken skeletal muscles of Selenomethionine (SeMet) use, 36 chicks were fed with SeMet feeding for 35 days. A total of 72 1-day old broiler chicks were randomly allocated into two groups (n = 36/group): the control group (C group), the SeMet supplemented group (SeMet group). The Selenium (Se) concentrations of skeletal muscles from the chicks with basal diet (negative control group) and SeMet feeding were found to be 0. Read More

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http://dx.doi.org/10.1007/s10534-019-00229-wDOI Listing
February 2020

Investigation of total zinc contents and zinc-protein profile in medicinal plants traditionally used for diabetes treatment.

Biometals 2020 02 6;33(1):65-74. Epub 2019 Dec 6.

Research Unit Analytical BioGeoChemistry, Helmholtz Center, Munich, Germany.

This study aims at the assessment of total zinc contents, water zinc extract contents and zinc-protein profile in medicinal plants traditionally used for diabetes treatment. While zinc-protein profile was screened in plant samples using the online coupling of size exclusion chromatography-inductively coupled plasma-mass spectrometry (SEC-ICP-MS), total zinc contents and zinc water extract contents were determined using inductively coupled plasma-optical emission spectrometry (ICP-OES). The analysis of two certified reference materials with similar matrix for total zinc content revealed recovery values of 97. Read More

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http://dx.doi.org/10.1007/s10534-019-00230-3DOI Listing
February 2020

Investigation of PIC1 (permease in chloroplasts 1) gene's role in iron homeostasis: bioinformatics and expression analyses in tomato and sorghum.

Biometals 2020 02 4;33(1):29-44. Epub 2019 Dec 4.

Department of Agricultural Biotechnology, Akdeniz University, Antalya, Turkey.

Iron (Fe) is a crucial micronutrient in plant metabolism; thus, iron homeostasis is critical for plant development. Permease in chloroplast 1 (PIC1) is the first protein determined in the chloroplast playing a role iron homeostasis. In the present study, the PIC1 gene was investigated at a genome-wide scale in four plant genomes; Arabidopsis, tomato, maize and sorghum. Read More

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http://dx.doi.org/10.1007/s10534-019-00228-xDOI Listing
February 2020

Using FluoZin-3 and fura-2 to monitor acute accumulation of free intracellular Cd in a pancreatic beta cell line.

Biometals 2019 12 21;32(6):951-964. Epub 2019 Nov 21.

Departments of Pharmacology, College of Graduate Studies, Midwestern University, 555 31st Street, Downers Grove, IL, 60515, USA.

The understanding of cellular Cd accumulation and toxicity is hampered by a lack of fluorescent indicators selective for intracellular free Cd ([Cd]). In this study, we used depolarized MIN6 mouse pancreatic beta cells as a model for evaluating [Cd] detection with commercially available fluorescent probes, most of which have been traditionally used to visualize [Ca] and [Zn]. We trialed a panel of 12 probes including fura-2, FluoZin-3, Leadmium Green, Rhod-5N, indo-1, Fluo-5N, and others. Read More

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http://dx.doi.org/10.1007/s10534-019-00226-zDOI Listing
December 2019

Correction to: Structural and solution chemistry, antiproliferative effects, and serum albumin binding of three pseudohalide derivatives of auranofin.

Biometals 2019 Dec;32(6):949

Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124, Pisa, Italy.

In the initial online publication, the given name of the first author was incorrectly displayed and should have read Damiano. The original article has been corrected and the proper representation of the authors' names and their affiliation is also listed here. Read More

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http://dx.doi.org/10.1007/s10534-019-00227-yDOI Listing
December 2019

Structural and solution chemistry, antiproliferative effects, and serum albumin binding of three pseudohalide derivatives of auranofin.

Biometals 2019 12 19;32(6):939-948. Epub 2019 Nov 19.

Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124, Pisa, Italy.

Three pseudohalide analogues of the established gold drug auranofin (AF hereafter), of general formula Au(PEt)X, i.e. Au(PEt)CN, Au(PEt)SCN and Au(PEt)N (respectively denoted as AFCN, AFSCN and AFN), were prepared and characterized. Read More

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http://dx.doi.org/10.1007/s10534-019-00224-1DOI Listing
December 2019

Characterization of the copper-sensing transcriptional regulator CopR from the hyperthermophilic archeaon Thermococcus onnurineus NA1.

Biometals 2019 12 1;32(6):923-937. Epub 2019 Nov 1.

Department of Biology, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea.

A putative copper ion-sensing transcriptional regulator CopR (TON_0836) from Thermococcus onnurineus NA1 was characterized. The CopR protein consists of a winged helix-turn-helix DNA-binding domain in the amino-terminal region and a TRASH domain that is assumed to be involved in metal ion-sensing in the carboxyl-terminal region. The CopR protein was most strongly bound to a region between its own gene promoter and a counter directional promoter region for copper efflux system CopA. Read More

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http://dx.doi.org/10.1007/s10534-019-00223-2DOI Listing
December 2019

DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage.

Biometals 2019 12 17;32(6):909-921. Epub 2019 Oct 17.

Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

Breast cancer is a leading cause of cancer-related death in women; however, chemotherapy of breast cancer is often hindered by dose-limiting toxicities, demonstrating the need for less toxic approaches to treatment. Since the rapid growth and metabolism of breast cancer cells results in an increased requirement for iron, withdrawal of bioavailable iron using highly selective iron chelators has been suggested to represent a new approach to breast cancer treatment. Here we show that the recently developed iron-binding polymer DIBI inhibited the growth of five different breast cancer cell lines (SK-BR3, MDA-MB-468, MDA-MB-231, MCF-7, and T47D). Read More

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http://dx.doi.org/10.1007/s10534-019-00222-3DOI Listing
December 2019

Wilson disease missense mutations in ATP7B affect metal-binding domain structural dynamics.

Biometals 2019 12 9;32(6):875-885. Epub 2019 Oct 9.

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Gothenburg, Sweden.

Wilson disease (WD) is caused by mutations in the gene for ATP7B, a copper transport protein that regulates copper levels in cells. A large number of missense mutations have been reported to cause WD but genotype-phenotype correlations are not yet established. Since genetic screening for WD may become reality in the future, it is important to know how individual mutations affect ATP7B function, with the ultimate goal to predict pathophysiology of the disease. Read More

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http://dx.doi.org/10.1007/s10534-019-00219-yDOI Listing
December 2019
1 Read
2.503 Impact Factor

Ytterbium increases transmembrane water transport in Zea mays roots via aquaporin modulation.

Biometals 2019 12 5;32(6):901-908. Epub 2019 Oct 5.

Kazan (Volga region) Federal University, Kremlyovskaya st., 18, 420008, Kazan, Russia.

In our study, the rare earth element ytterbium (Yb) was demonstrated to affect water exchange in roots of Zea mays seedlings. Herewith, the overall membrane permeability (P) increased. The P increase was determined by aquaporin activity but not the membrane lipid component since the closure of aquaporin channels due to low intracellular pH abolished the positive effect of Yb on P. Read More

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http://dx.doi.org/10.1007/s10534-019-00221-4DOI Listing
December 2019
5 Reads

Cadmium-dependent expression of a new metallothionein identified in Trichomonas vaginalis.

Biometals 2019 12 4;32(6):887-899. Epub 2019 Oct 4.

Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), San Lorenzo # 290, Col. Del Valle, CP 03100, Mexico City, Mexico.

Metallothioneins (MTs) have been identified in a wide variety of organisms from bacteria to humans. The biological functions of these MTs have a key role in metalloregulatory metabolism and its expression is induced in response to different stimuli, particularly by divalent metal cations. Also, the action of MTs have been implicated in the survival of pathogens in presence of microbicidal concentration of divalent cations, which allows the establishment of the infection. Read More

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http://dx.doi.org/10.1007/s10534-019-00220-5DOI Listing
December 2019

Protein kinase CK2 is involved in zinc homeostasis in breast and prostate cancer cells.

Biometals 2019 12 3;32(6):861-873. Epub 2019 Oct 3.

School of Science and Health, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

The intracellular zinc profiles of breast and prostate cancer cells are diametrically opposed, with hyper-accumulation of zinc in breast cancer, and low level in prostate cancer. This phenomenon is poorly understood. This study employs two breast and two prostate cancer cell lines to investigate the role of protein kinase CK2 in regulating zinc homeostasis. Read More

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http://dx.doi.org/10.1007/s10534-019-00218-zDOI Listing
December 2019

Novel contrast media based on the liquid metal gallium for in vivo digestive tract radiography: a feasibility study.

Biometals 2019 10 25;32(5):795-801. Epub 2019 Sep 25.

Chinese Academy of Sciences Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Beijing, 100190, China.

The barium sulfate has been playing an important role as the contrast medium in gastrointestinal radiography and disease diagnosis. However, its application has been gradually reduced due to the limitation of its imaging effect and the progress of other imaging techniques. Here, the liquid metal gallium was proposed as an improved contrast agent, which was applied in the in vivo digestive tract radiography of the mice for the first time. Read More

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http://dx.doi.org/10.1007/s10534-019-00212-5DOI Listing
October 2019
1 Read
2.503 Impact Factor

Functional analysis of recombinant buffalo lactoferrin and monoferric lobes and their cytotoxic effect on buffalo mammary epithelial cells.

Biometals 2019 10 25;32(5):771-783. Epub 2019 Sep 25.

Animal Biotechnology Centre, ICAR-National Dairy Research Institute, Karnal, 132 001, India.

Lactoferrin (Lf) has been involved in diverse type of cellular activities and its biochemical properties are species specific. Lf is a bilobal molecule in which each lobe binds with one Fe/Fe ion. A lot of physiological effects of Lf are regulated by its iron binding and release properties; however these properties are species-specific. Read More

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http://dx.doi.org/10.1007/s10534-019-00209-0DOI Listing
October 2019
2.503 Impact Factor

Vanadium compounds induced damage of human umbilical vein endothelial cells and the protective effect of berberine.

Biometals 2019 10 24;32(5):785-794. Epub 2019 Sep 24.

School of Pharmacy, Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, Hebei, People's Republic of China.

This study was conducted to investigate the damage caused by vanadium compounds and to explore the protective effects of berberine (BBR) in human umbilical vein endothelial cells (HUVECs). BBR is a biologically active small molecule found in Coptis rhizome, a remedy used in traditional Chinese medicine to treat diabetes. BBR has also been shown to lower blood glucose in diabetic patients. Read More

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http://dx.doi.org/10.1007/s10534-019-00211-6DOI Listing
October 2019
1 Read

Bismuth(III) interactions with Desulfovibrio desulfuricans: inhibition of cell energetics and nanocrystal formation of BiS and Bi.

Biometals 2019 10 23;32(5):803-811. Epub 2019 Sep 23.

Department of Medicine, University of New Mexico and New Mexico VA Health Care System, Albuquerque, NM, 87018, USA.

Sulfate-reducing bacteria have been suggested to have an etiological role in the development of inflammatory bowel diseases and ulcerative colitis in humans. Traditionally. bismuth compounds have been administered to alleviate gastrointestinal discomfort and disease symptoms. Read More

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http://dx.doi.org/10.1007/s10534-019-00213-4DOI Listing
October 2019
1 Read

H-Aquil: a chemically defined cell culture medium for trace metal studies in Vibrios and other marine heterotrophic bacteria.

Biometals 2019 12 21;32(6):819-828. Epub 2019 Sep 21.

Department of Geosciences, Princeton University, Princeton, NJ, 08544, USA.

A variety of trace metals, including prominently iron (Fe) are necessary for marine microorganisms. Chemically defined medium recipes have been used for several decades to study phytoplankton, but similar methods have not been adopted as widely in studies of marine heterotrophic bacteria. Medium recipes for these organisms frequently include tryptone, casamino acids, as well as yeast and animal extracts. Read More

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http://dx.doi.org/10.1007/s10534-019-00215-2DOI Listing
December 2019
3 Reads

Zinc deficiency alters the susceptibility of pancreatic beta cells (INS-1) to arsenic exposure.

Biometals 2019 12 21;32(6):845-859. Epub 2019 Sep 21.

School of Biological and Population Health Sciences, Oregon State University, 103 Milam Hall, Corvallis, OR, 97331, USA.

Pancreatic beta cells produce and release insulin, a hormone that regulates blood glucose levels, and their dysfunction contributes to the development of diabetes mellitus. Zinc deficiency and inorganic arsenic exposure both independently associate with the development of diabetes, although the effects of their combination on pancreatic beta cell health and function remain unknown. We hypothesized zinc deficiency increases the toxicity associated with arsenic exposure, causing an increased susceptibility to DNA damage and disruption of insulin production. Read More

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http://dx.doi.org/10.1007/s10534-019-00217-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891200PMC
December 2019
2 Reads

Reactive oxygen species, auxin and nitric oxide in metal-stressed roots: toxicity or defence.

Biometals 2019 10 21;32(5):717-744. Epub 2019 Sep 21.

Institute of Botany, Plant Science and Biodiversity Centre, Slovak Academy of Sciences, Dúbravská cesta 9, 84523, Bratislava, Slovak Republic.

The presented review is a summary on the current knowledge about metal induced stress response in plants, focusing on the roles of reactive oxygen species, auxin and nitric oxide in roots. The article focuses mainly on the difference between defence and toxicity symptoms of roots during metal-induced stress. Nowadays, pollution of soils by heavy metals is a rapidly growing issue, which affects agriculture and human health. Read More

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http://dx.doi.org/10.1007/s10534-019-00214-3DOI Listing
October 2019
2 Reads

ZIP14 is degraded in response to manganese exposure.

Biometals 2019 12 20;32(6):829-843. Epub 2019 Sep 20.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.

Manganese (Mn) is an essential element necessary for proper development and brain function. Circulating Mn levels are regulated by hepatobiliary clearance to limit toxic levels and prevent tissue deposition. To characterize mechanisms involved in hepatocyte Mn uptake, polarized human HepaRG cells were used for this study. Read More

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http://dx.doi.org/10.1007/s10534-019-00216-1DOI Listing
December 2019

The leading established metal-based drugs: a revisitation of their relevant physico-chemical data.

Biometals 2019 10 31;32(5):813-817. Epub 2019 Aug 31.

Laboratory of Metals in Medicine (MetMed), Department of Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Italy.

The study of metal-based drugs represents an important branch of modern bioinorganic chemistry. The growing importance of this field is linked to the large success in medicine of a few metal based drugs, either in clinical use or still experimental. Moreover, these metal-based drugs are frequently used as reference compounds to assess comparatively the behavior of newly synthesized metallodrugs. Read More

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http://dx.doi.org/10.1007/s10534-019-00210-7DOI Listing
October 2019

A direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement.

Biometals 2019 10 31;32(5):745-755. Epub 2019 Jul 31.

National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Chapel Hill, NC, USA.

Hinokitiol, a natural lipophilic chelator, appears capable of replacing several iron transporters after they have been genetically ablated. Divalent metal-ion transporter (DMT1) is the major iron importer in enterocytes and erythroblasts. We have compared DMT1 and hinokitiol in multiple fashions to learn if the smaller molecule is a suitable substitute using two HEK293 cell lines engineered to overexpress different isoforms of DMT1. Read More

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http://dx.doi.org/10.1007/s10534-019-00207-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768898PMC
October 2019
10 Reads

Molecular cloning, expression and characterization of secreted ferritin in the silkworm, Bombyx mori.

Biometals 2019 10 30;32(5):757-769. Epub 2019 Jul 30.

Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, 212013, People's Republic of China.

Ferritin is a ubiquitous iron storage protein which plays key role in regulating iron homeostasis and metabolism. In this paper, the ferritin heavy chain homologs (HCH) and light chain homologs (LCH) from Bombyx mori (BmFerHCH and BmFerLCH) were amplified through PCR and cloned into the expression vector pET-30a(+). The recombinant BmFerHCH and BmFerLCH expressed in Escherichia coli were in the form of insoluble inclusion bodies, indicating that the two proteins were not in their natural structural conformation. Read More

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http://dx.doi.org/10.1007/s10534-019-00208-1DOI Listing
October 2019
8 Reads

Copper-zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1.

Biometals 2019 08 10;32(4):695-705. Epub 2019 Jul 10.

Department of Biological Sciences, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX, 75080, USA.

Copper-zinc superoxide dismutase (Sod1) is a critical antioxidant enzyme that rids the cell of reactive oxygen through the redox cycling of a catalytic copper ion provided by its copper chaperone (Ccs). Ccs must first acquire this copper ion, directly or indirectly, from the influx copper transporter, Ctr1. The three proteins of this transport pathway ensure careful trafficking of copper ions from cell entry to target delivery, but the intricacies remain undefined. Read More

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http://dx.doi.org/10.1007/s10534-019-00206-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647829PMC

Gadolinium chloride promotes proliferation of HEK293 human embryonic kidney cells by activating EGFR/PI3K/Akt and MAPK pathways.

Biometals 2019 08 8;32(4):683-693. Epub 2019 Jul 8.

State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing, 100191, People's Republic of China.

Prolonged exposure to gadolinium-based contrast agents has been reported to trigger nephrogenic systemic fibrosis in end stage renal disease patients. However, the exact molecular mechanisms are not fully understood, and no effective therapy is available to date. In the present study, we report that gadolinium chloride (Gd) concentration- and time-dependently promoted the proliferation of HEK293 human embryonic kidney cells by increasing DNA synthesis. Read More

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http://dx.doi.org/10.1007/s10534-019-00205-4DOI Listing
August 2019
5 Reads

Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag and Mn complexes.

Biometals 2019 08 22;32(4):671-682. Epub 2019 Jun 22.

Department of General Microbiology, Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag and Mn complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)]NO, [Ag(1)]BF and [Mn(1)](NO). Polymeric {[Ag(1)(NO)]} has 1:1 stoichiometry and forms upon infusion of CHCl into a DMSO solution of [Ag(1)]NO. Read More

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http://dx.doi.org/10.1007/s10534-019-00204-5DOI Listing
August 2019
9 Reads

Genome-wide analysis of zinc- and iron-regulated transporter-like protein family members in apple and functional validation of ZIP10.

Biometals 2019 08 19;32(4):657-669. Epub 2019 Jun 19.

State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.

Deficiency of zinc (Zn) and iron (Fe) is common in apple grown in orchards, which affects fruit yield and quality. However, the mechanisms of absorption and transport of Zn and Fe in apples are still unclear. In the present study, we aimed to identify MdZIP genes and explore the mechanism of response of MdZIPs to Zn and Fe deficiencies. Read More

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http://dx.doi.org/10.1007/s10534-019-00203-6DOI Listing
August 2019
1 Read

Enhancement of oncolytic virotherapy by vanadium(V) dipicolinates.

Biometals 2019 06 17;32(3):545-561. Epub 2019 Jun 17.

Department of Chemistry, Colorado State University, Fort Collins, CO, USA.

Oncolytic viruses rewire the immune system and can lead to long-lasting antitumor defenses against primary and metastatic tumors. However, results from clinical studies have shown heterogeneity in responses suggesting that multiplexed approaches may be necessary to consistently generate positive outcomes in patients. To this end, we explored the combination of oncolytic rhabdovirus VSV∆51 with vanadium(V) dipicolinate derivatives, which have already been explored for their antidiabetic properties in animal models. Read More

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http://dx.doi.org/10.1007/s10534-019-00200-9DOI Listing
June 2019
26 Reads

New insights into the tetrameric family of the Fur metalloregulators.

Biometals 2019 06 4;32(3):501-519. Epub 2019 Jun 4.

Univ-Grenoble Alpes, CEA, CNRS, BIG, CBM, CEA-Grenoble, 38000, Grenoble, France.

The ferric uptake regulator (Fur) belongs to the family of the metal-responsive transcriptional regulators. Fur is a global regulator found in all proteobacteria. It controls the transcription of a wide variety of genes involved in iron metabolism but also in oxidative stress or virulence factor synthesis. Read More

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http://dx.doi.org/10.1007/s10534-019-00201-8DOI Listing
June 2019
8 Reads

Antioxidant activity and cellular uptake of the hydroxamate-based fungal iron chelators pyridoxatin, desferriastechrome and desferricoprogen.

Biometals 2019 08 1;32(4):707-715. Epub 2019 Jun 1.

Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo, 05508-000, Brazil.

The hydroxamate class of compounds is well known for its pharmacological applications, especially in the context of chelation therapy. In this work we investigate the performance of the fungal hydroxamates pyridoxatin (PYR), desferriastechrome (DAC) and desferricoprogen (DCO) as mitigators of stress caused by iron overload (IO) both in buffered medium and in cells. Desferrioxamine (DFO), the gold standard for IO treatment, was used as comparison. Read More

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http://dx.doi.org/10.1007/s10534-019-00202-7DOI Listing
August 2019
1 Read

DNA profiling and in vitro cytotoxicity studies of tetrazolo[1,5-a]pyrimidine-based copper(II) complexes.

Biometals 2019 08 16;32(4):611-626. Epub 2019 May 16.

Post-Graduate and Research Department of Chemistry, The New College (Autonomous), Chennai, 600 014, India.

A series of N-benzoylated mononuclear copper(II) complexes of the type [Cu(L)Cl] (1-6), where L= ethyl 4-benzoyl-5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L= ethyl 4-(4-nitrobenzoyl)-5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L = ethyl 4-benzoyl-5-methyl-7-(4-methoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L = ethyl 4-(4-nitrobenzoyl)-5-methyl-7-(4-methoxyphenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, L = ethyl 4-benzoyl-5-methyl-7-(4-chlorophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate and L = ethyl 4-(4-nitrobenzoyl)-5-methyl-7-(4-chlorophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate have been synthesized and characterized by spectral methods. Electron paramagnetic resonance spectra of complexes show four lines, characteristic of square planar geometry. The binding studies of the complexes with calf thymus DNA (CT-DNA) revealed groove mode of binding, which were further supported by molecular docking studies. Read More

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http://link.springer.com/10.1007/s10534-019-00196-2
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http://dx.doi.org/10.1007/s10534-019-00196-2DOI Listing
August 2019
3 Reads

The interaction of silver(II) complexes with biological macromolecules and antioxidants.

Biometals 2019 08 16;32(4):627-640. Epub 2019 May 16.

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.

Silver is widely used for its antimicrobial properties, but microbial resistance to heavy metals is increasing. Silver(II) compounds are more oxidizing and therefore have the potential to overcome resistance via extensive attack on cellular components, but have traditionally been hard to stabilize for biological applications. Here, the high oxidation state cation was stabilised using pyridinecarboxylate ligands, of which the 2,6-dicarboxypyridine Ag(II) complex (Ag2,6P) was found to have the best tractability. Read More

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http://dx.doi.org/10.1007/s10534-019-00198-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647504PMC
August 2019
1 Read

A key gene bHLH115 in iron homeostasis: comprehensive bioinformatics analyses in Arabidopsis, tomato, rice, and maize.

Biometals 2019 08 6;32(4):641-656. Epub 2019 May 6.

Department of Chemistry, Faculty of Science, Dicle University, Diyarbakir, Turkey.

bHLH115 transcription factor (TF) is a positive regulator of the Fe-deficiency and plays essential roles in the stress-related regulation network. In this study, orthologous bHLH115 genes in Arabidopsis, tomato, rice, and maize were analyzed using in silico methods. All bHLH115 proteins contained PF00010 (HLH: Helix-loop-helix DNA-binding domain) domain structure and their sub-cellular localizations were predicted as nucleus. Read More

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http://dx.doi.org/10.1007/s10534-019-00199-zDOI Listing
August 2019
7 Reads

Biguanide is a modifiable pharmacophore for recruitment of endogenous Zn to inhibit cysteinyl cathepsins: review and implications.

Biometals 2019 08 1;32(4):575-593. Epub 2019 May 1.

Departmant of Pharmacology, School of Medicine, Wright State University, Dayton, OH, 45435, USA.

Excessive activities of cysteinyl cathepsins (CysCts) contribute to the progress of many diseases; however, therapeutic inhibition has been problematic. Zn is a natural inhibitor of proteases with CysHis dyads or CysHis(Xaa) triads. Biguanide forms bidentate metal complexes through the two imino nitrogens. Read More

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http://dx.doi.org/10.1007/s10534-019-00197-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647370PMC
August 2019
1 Read

The impact of probiotics and lactoferrin supplementation on piglet gastrointestinal microbial communities.

Biometals 2019 06 30;32(3):533-543. Epub 2019 Apr 30.

Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.

Probiotics and lactoferrin are currently being used in neonatal intensive care units in the hopes of reducing rates of sepsis and necrotizing enterocolitis (NEC). While studies have shown that these measures can be clinically beneficial to premature babies, and there are ongoing trials to measure their impact on NEC and sepsis rates, little is known about how they may impact microbiota development. We thus employed a newborn piglet model to assess the impact of feeding probiotics or a combination of probiotics and lactoferrin on development of the gastrointestinal microbiota. Read More

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http://link.springer.com/10.1007/s10534-019-00195-3
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http://dx.doi.org/10.1007/s10534-019-00195-3DOI Listing
June 2019
11 Reads

Safe coordinated trafficking of heme and iron with copper maintain cell homeostasis: modules from the hemopexin system.

Biometals 2019 06 22;32(3):355-367. Epub 2019 Apr 22.

School of Biological Sciences, University of Missouri, Kansas, USA.

Studies with patients, animal models of human disease and hemopexin null mice have shown that the heme-binding protein hemopexin is vital for the protection of a variety of cell types and tissues against heme toxicity. The presence of hemopexin in all biological fluids examined to date indicates wide roles in abrogating heme toxicity in human tissues; and, thus, is clinically relevant. Heme-hemopexin endocytosis leads to coordinated trafficking of heme, iron and copper as heme traffics from endosomes to heme oxygenases (HOs) in the smooth endoplasmic reticulum and to the nucleus. Read More

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http://dx.doi.org/10.1007/s10534-019-00194-4DOI Listing
June 2019
3 Reads

Exposure routes and health effects of heavy metals on children.

Biometals 2019 08 2;32(4):563-573. Epub 2019 Apr 2.

Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha, 410078, China.

Heavy metals are naturally existing elements that have relatively high atomic weight and a minimum density five times the density of water. Heavy metals have extensive applications in industries, homes, agriculture and medicine, leading to their wide distribution in the environment. Most heavy metals are reported to be highly toxic. Read More

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http://dx.doi.org/10.1007/s10534-019-00193-5DOI Listing
August 2019
50 Reads

The indispensable role of mammalian iron sulfur proteins in function and regulation of multiple diverse metabolic pathways.

Authors:
Tracey A Rouault

Biometals 2019 06 28;32(3):343-353. Epub 2019 Mar 28.

National Institutes of Health, Bethesda, MD, 20892, USA.

In recent years, iron sulfur (Fe-S) proteins have been identified as key players in mammalian metabolism, ranging from long-known roles in the respiratory complexes and the citric acid cycle, to more recently recognized roles in RNA and DNA metabolism. Fe-S cofactors have often been missed because of their intrinsic lability and oxygen sensitivity. More Fe-S proteins have now been identified owing to detection of their direct interactions with components of the Fe-S biogenesis machinery, and through use of informatics to detect a motif that binds the co-chaperone responsible for transferring nascent Fe-S clusters to domains of recipient proteins. Read More

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http://link.springer.com/10.1007/s10534-019-00191-7
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http://dx.doi.org/10.1007/s10534-019-00191-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584224PMC
June 2019
7 Reads

Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics.

Biometals 2019 06 27;32(3):425-451. Epub 2019 Mar 27.

Hsiri Therapeutics, Rosetree Corporate Center, 1400 N. Providence Road, Building 1, Suite 115S, Media, PA, 19063, USA.

New or repurposed antibiotics are desperately needed since bacterial resistance has risen to essentially all of our current antibiotics, and few new antibiotics have been developed over the last several decades. A primary cause of drug resistance is the overuse of antibiotics that can result in alteration of microbial permeability, alteration of drug target binding sites, induction of enzymes that destroy antibiotics (i.e. Read More

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http://dx.doi.org/10.1007/s10534-019-00192-6DOI Listing
June 2019
5 Reads

Staphylococcus aureus heme and siderophore-iron acquisition pathways.

Biometals 2019 06 25;32(3):409-424. Epub 2019 Mar 25.

Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, V6T 1Z3, Canada.

Staphylococcus aureus is a versatile opportunistic human pathogen. Infection by this bacterium requires uptake of iron from the human host, but iron is highly restricted in this environment. Staphylococcus aureus iron sufficiency is achieved primarily through uptake of heme and high-affinity iron chelators, known as siderophores. Read More

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http://link.springer.com/10.1007/s10534-019-00188-2
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http://dx.doi.org/10.1007/s10534-019-00188-2DOI Listing
June 2019
23 Reads

Synthesis, structural elucidation and antiradical activity of a copper (II) naringenin complex.

Biometals 2019 08 25;32(4):595-610. Epub 2019 Mar 25.

INQUIMAE, CONICET, Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II - Ciudad Universitaria - Núñez, C1428EHA, CABA, Argentina.

Coupling the extraction and derivatization of flavonoids to the Citrus processing industry is attractive from both the environmental and economic points of view. In the present work, the flavonoid naringin, obtained by "green" extraction with a water:ethanol mixture from waste grapefruit industry, was hydrolyzed to obtain naringenin. This flavonoid was used to synthesize the complex trans-di(aqua) bis(7-hydroxy-2-(4-hydroxyphenyl)-4-oxo-5-chromanolato) copper (II). Read More

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http://link.springer.com/10.1007/s10534-019-00187-3
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http://dx.doi.org/10.1007/s10534-019-00187-3DOI Listing
August 2019
2 Reads