58,646 results match your criteria Biomedicine & Pharmacotherapy[Journal]


Facile fabrication of functional hydrogels consisting of pullulan and polydopamine fibers for drug delivery.

Int J Biol Macromol 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

With the rapid development of drug delivery vehicles, more flexible and efficient fabrication strategies are required for biomedicine applications. Naturally resourced polymers have gained considerable attention for construction of drug carriers. Here, biocompatible hydrogel reservoir system (named PHG-PDA) based on pullulan (Pu) and polydopamine (PDA) are designed and fabricated by one-pot incorporation of PDA fibers into pullulan hydrogel (PHG). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.283DOI Listing

Type 5 phosphodiesterase (PDE5) and the vascular tree: from embryogenesis to aging and disease.

Mech Ageing Dev 2020 Jul 3:111311. Epub 2020 Jul 3.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address:

Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111311DOI Listing

Monodisperse and polydisperse PEGylation of peptides and proteins: a comparative study.

Biomacromolecules 2020 Jul 6. Epub 2020 Jul 6.

Although PEGylation is widely used in biomedicine with great success, it suffers many drawbacks, such as polydispersity, non-biodegradability, and loss of precursor potency. Recently, the search for polyethylene glycols (PEGs) substitutes has attracted considerable attention. Some of the substitutes partially address the drawbacks of PEGs, but sacrifice the "stealth" effect of PEGs and bring in new issues. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00517DOI Listing

Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS).

J Neurochem 2020 Jul 6. Epub 2020 Jul 6.

Department of Molecular Biomedicine, Centro de Investigaciones Biológicas, Margarita Salas (CSIC), Ramiro de Maéztu 9, 28040, Madrid, Spain.

TDP-43 has been identified as the major component of protein aggregates found in affected neurons in FTLD-TDP and ALS patients. TDP-43 is hyperphosphorylated, ubiquitinated and cleaved in the C-terminus. CDC-7 was reported to phosphorylate TDP-43. Read More

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http://dx.doi.org/10.1111/jnc.15118DOI Listing

An Ultrasmall RuO Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injury.

ACS Appl Mater Interfaces 2020 Jul 6. Epub 2020 Jul 6.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.

Oxidative stress induced by reactive oxygen species (ROS) is one of the major pathological mechanisms of acute kidney injury (AKI). Inorganic nanomaterial-mediated antioxidant therapy is considered a promising method for the prevention of AKI; however, currently available antioxidants for AKI exhibit limited clinical efficacy due to the glomerular filtration threshold (∼6 nm). To address this issue, we developed ultrasmall RuO nanoparticles (RuONPs) (average size ≈ 2 nm). Read More

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http://dx.doi.org/10.1021/acsami.0c07886DOI Listing

Intracellular, Ruthenium-Promoted (2+2+2) Cycloadditions.

Angew Chem Int Ed Engl 2020 Jul 6. Epub 2020 Jul 6.

Universidade de Santiago de Compostela, CIQUS and Departamento de Química Orgánica, C/ jenaro de la Fuente s/n, 15782, Santiago de Compostela, SPAIN.

Metal-mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and promise to strongly impact the field of biomedicine. Most of the reactions so far reported involve uncaging or redox processes. We now demonstrate for the first time the viability of performing multicomponent alkyne cycloaromatizations inside live mammalian cells, using ruthenium catalysts. Read More

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http://dx.doi.org/10.1002/anie.202006689DOI Listing

Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity.

Biomater Sci 2020 Jul 6. Epub 2020 Jul 6.

State Key Laboratory of Analytical Chemistry for Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging. In the past few years, a number of intelligent molecular imaging probes with fluorescence, magnetic resonance imaging (MRI), positron electron tomography (PET) or photoacoustic imaging (PA) modality have been developed based on the in situ self-assembly strategy. In this minireview, we summarize the recent advances in the development of different modality imaging probes through controlling in situ self-assembly for in vivo imaging of enzymatic activity. Read More

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http://dx.doi.org/10.1039/d0bm00895hDOI Listing

Neurolymphomatosis, a rare manifestation of peripheral nerve involvement in lymphomas: suggestive features and diagnostic challenges.

J Peripher Nerv Syst 2020 Jul 5. Epub 2020 Jul 5.

Neurology Unit, Department of Neuroscience, University of Padova, Padova, Italy.

Background: Neurolymphomatosis, the infiltration of the peripheral nervous system from lymphoid cells, represents an uncommon manifestation of lymphomas. We describe the challenging diagnostic work-up in a patient with neurolymphomatosis.

Case Report: a 58-yr-old woman with previous breast diffuse large B-cell lymphoma (DLBCL) treated with chemo- and radiation-therapy, presented with dysesthesias, neuropathic pain at left abdomen and thigh, and weakness at left lower limb 9 years after disease remission. Read More

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http://dx.doi.org/10.1111/jns.12401DOI Listing

Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage.

Mol Cell Biochem 2020 Jul 5. Epub 2020 Jul 5.

Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.

P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel which mediates ATP-induced inflammation in macrophages. Transient receptor potential (TRP) receptors are nociceptors in cellular membrane which can perceive the stimuli of environmental irritant. The interaction between TRP channels and P2X7R has been found while the details about inflammation are still unclear. Read More

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http://dx.doi.org/10.1007/s11010-020-03818-3DOI Listing

Social contacts, friends and satisfaction with friendships in patients with psychotic, mood and neurotic disorders 1 year after hospitalisation: data from five European countries.

Soc Psychiatry Psychiatr Epidemiol 2020 Jul 5. Epub 2020 Jul 5.

Unit for Social and Community Psychiatry (World Health Organisation Collaborating Centre for Mental Health Services Development), Queen Mary University of London, London, UK.

Background: People with severe mental illness often struggle with social relationships, but differences among diagnostic groups are unclear. We assessed and compared objective and subjective social relationship indicators among patients with psychotic, mood and neurotic disorders one year after hospitalisation in five European countries (Belgium, Germany, Italy, Poland and United Kingdom).

Methods: The number of social contacts, including family members and friends during the previous week (Social Network Schedule), and satisfaction with the number and quality of friendships (Manchester Short Assessment of Quality of Life Quality) were assessed by face-to-face interview. Read More

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http://dx.doi.org/10.1007/s00127-020-01915-8DOI Listing

Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation.

Int J Mol Med 2020 Aug 3;46(2):546-560. Epub 2020 Jun 3.

CONACyT, Metabolomics and Proteomics Laboratory, Academic Unit of Biological Sciences, Universidad Autónoma de Zacatecas, Zacatecas 98068, Mexico.

Placenta‑derived exosomes play an important role in cellular communication both in the mother and the fetus. Their concentration and composition are altered in several pregnancy disorders, such as gestational diabetes mellitus (GDM). The isolation and characterization of placental exosomes from serum, plasma and tissues from patients with GDM have been previously described; however, to the best of our knowledge, to date, there is no study available on placental exosomes isolated from urine of patients with GDM. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4626DOI Listing

Functional Motor Disorders Mimicking Symptoms Upon Resolution of Cerebrovascular Disease.

Mov Disord Clin Pract 2020 Jul 31;7(5):552-554. Epub 2020 May 31.

Neurology Unit, Movement Disorders Division, Department of Neurosciences Biomedicine and Movement Sciences, University of Verona Verona Italy.

Background: Functional motor disorders encompass a variety of manifestations characterized by abnormal movements that are clinically incongruent with those known to be caused by neurological diseases.

Cases: We report 2 cases in which functional motor disorders developed after complete recovery of motor symptoms originating from underlying vascular brain lesions. The first case describes a young woman who developed a motor and sensory hemisyndrome after surgical removal of a postrolandic cavernoma. Read More

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http://dx.doi.org/10.1002/mdc3.12972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328412PMC

A Survey on HIV/AIDS-Related Knowledge, Attitudes, Risk Behaviors, and Characteristics of Men Who Have Sex with Men among University Students in Guangxi, China.

Biomed Res Int 2020 14;2020:7857231. Epub 2020 Jun 14.

Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.

In recent years, the prevalence of human immunodeficiency virus (HIV) infection among Chinese university students has increased significantly, and HIV transmission among men who have sex with men (MSM) comprises more than half of the new cases. There is still a lack of research investigating the incidence of male-to-male sex, the attitudes towards MSM, and the awareness of HIV/AIDS among university students in Guangxi, one of the HIV high-risk areas in China. Therefore, we performed a cross-sectional investigation among 578 male students, recruited by stratified sampling, in universities in Nanning, Guangxi, between January 2016 and March 2017. Read More

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http://dx.doi.org/10.1155/2020/7857231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312710PMC

Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.

Front Endocrinol (Lausanne) 2020 18;11:340. Epub 2020 Jun 18.

Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University Graz, Graz, Austria.

Non-alcoholic fatty liver disease (NAFLD) contributes essentially to the burden of obesity and can start in childhood. NAFLD can progress to cirrhosis and hepatocellular carcinoma. The early phase of NAFLD is crucial because during this time the disease is fully reversible. Read More

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http://dx.doi.org/10.3389/fendo.2020.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314945PMC

Epigenetics and Attention-Deficit/Hyperactivity Disorder: New Perspectives?

Front Psychiatry 2020 17;11:579. Epub 2020 Jun 17.

Department of Child and Adolescent Psychiatry, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.3389/fpsyt.2020.00579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311572PMC

Age-Dependent Statistical Changes of Involuntary Head Motion Signatures Across Autism and Controls of the ABIDE Repository.

Front Integr Neurosci 2020 17;14:23. Epub 2020 Jun 17.

Department of Psychology, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.

The DSM-5 definition of autism spectrum disorders includes sensory issues and part of the sensory information that the brain continuously receives comes from kinesthetic reafference, in the form of self-generated motions, including those that the nervous systems produce at rest. Some of the movements that we self-generate are deliberate, while some occur spontaneously, consequentially following those that we can control. Yet, some motions occur involuntarily, largely beneath our awareness. Read More

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http://dx.doi.org/10.3389/fnint.2020.00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311771PMC

Quantitative genome-wide association study of six phenotypic subdomains identifies novel genome-wide significant variants in autism spectrum disorder.

Transl Psychiatry 2020 Jul 5;10(1):215. Epub 2020 Jul 5.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Autism spectrum disorders (ASD) are highly heritable and are characterized by deficits in social communication and restricted and repetitive behaviors. Twin studies on phenotypic subdomains suggest a differing underlying genetic etiology. Studying genetic variation explaining phenotypic variance will help to identify specific underlying pathomechanisms. Read More

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http://dx.doi.org/10.1038/s41398-020-00906-2DOI Listing

Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children.

Exp Mol Med 2020 Jul 6. Epub 2020 Jul 6.

Institute of Biomedicine (IBIOMED), León, Spain.

Childhood obesity has reached epidemic levels and is a serious health concern associated with metabolic syndrome, nonalcoholic fatty liver disease, and gut microbiota alterations. Physical exercise is known to counteract obesity progression and modulate the gut microbiota composition. This study aims to determine the effect of a 12-week strength and endurance combined training program on gut microbiota and inflammation in obese pediatric patients. Read More

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http://dx.doi.org/10.1038/s12276-020-0459-0DOI Listing

Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.

Psychol Med 2020 Jul 6:1-22. Epub 2020 Jul 6.

King's College London, Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.

The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and psychosis. We conducted a systematic search of the PsychINFO, Embase, Ovid, and Web of Science databases for original articles investigating the role of genetic vulnerabilities, environmental factors, psychological and psychopathological mechanisms in the association between CA and psychosis up to August 2019. Read More

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http://dx.doi.org/10.1017/S0033291720002172DOI Listing

How far is single-cell sequencing from clinical application?

Clin Transl Med 2020 Jul 5. Epub 2020 Jul 5.

Department of Pulmonary and Critical Care Medicine, Clinical Center for Molecular Diagnosis and Therapy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.

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http://dx.doi.org/10.1002/ctm2.117DOI Listing

Aβ40 Oligomers Promote Survival and Early Neuronal Differentiation of Dentate Gyrus-Isolated Precursor Cells Through Activation of the Akt Signaling Pathway.

Neurotox Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV-IPN), Av. Instituto Politécnico Nacional 2508, 07360, Mexico City, Mexico.

The amyloid beta-peptide (Aβ) is the low-abundance product of amyloid precursor protein (APP), which is produced lifelong in the healthy brain. The functional properties of Aβ40 and Aβ42 peptides have not been completely elucidated to date. Although, several studies suggest that these peptides have a number of neurotrophic and neurotoxic properties, respectively. Read More

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http://dx.doi.org/10.1007/s12640-020-00253-6DOI Listing

Treatment of MOG antibody associated disorders: results of an international survey.

J Neurol 2020 Jul 4. Epub 2020 Jul 4.

Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.

Introduction: While monophasic and relapsing forms of myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are increasingly diagnosed world-wide, consensus on management is yet to be developed.

Objective: To survey the current global clinical practice of clinicians treating MOGAD.

Method: Neurologists worldwide with expertise in treating MOGAD participated in an online survey (February-April 2019). Read More

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http://dx.doi.org/10.1007/s00415-020-10026-yDOI Listing

German version of the outcome expectations for exercise scale-2 : Psychometric properties in geriatric patients after hip or pelvic fractures with fear of falling.

Z Gerontol Geriatr 2020 Jul 4. Epub 2020 Jul 4.

Department of Clinical Gerontology and Geriatric Rehabilitation, Robert-Bosch-Hospital, Stuttgart, Stuttgart, Germany.

Objective: Physical exercise is associated with many health benefits. Especially for older adults it is challenging to achieve an appropriate adherence to exercise programs. The outcome expectations for exercise scale 2 (OEE-2) is a 13-item self-report questionnaire to assess negative and positive exercise outcome expectations in older adults. Read More

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http://dx.doi.org/10.1007/s00391-020-01753-yDOI Listing

Chromosome 6p SNP microhaplotypes and IgG3 levels in hemochromatosis probands with HFE p.C282Y homozygosity.

Blood Cells Mol Dis 2020 Jun 27;85:102461. Epub 2020 Jun 27.

Institute for Molecular and Cell Biology (IBMC), i3S (Instituto de Investigação e Inovação em Saúde), Universidade do Porto, Porto, Portugal; Clinical Hematology, Santo António Hospital - Porto University Hospital Center (CHUP), Porto, Portugal; Molecular Pathology and Immunology, Abel Salazar Institute for Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal. Electronic address:

Subnormal IgG1 or IgG3 levels occurred in 30% of hemochromatosis probands with HFE p.C282Y homozygosity and were concordant in HLA-identical siblings. We sought to identify factors associated with IgG subclasses in Alabama probands with p. Read More

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http://dx.doi.org/10.1016/j.bcmd.2020.102461DOI Listing

The response of the mental health network of the Salamanca area to the COVID-19 pandemic: The role of the telemedicine.

Psychiatry Res 2020 Jul 1;291:113252. Epub 2020 Jul 1.

Psychiatry Service, University of Salamanca Healthcare Complex (USHC), Salamanca, Spain; Institute of Biomedicine of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain; School of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain.

The COVID-19 pandemic reached world-wide causing a great impact on healthcare services. The aim of this work is to describe the response of the Mental Health Network of the Salamanca´ Area (Spain) to this crisis and the reorganization of its resources within the first 8 weeks after the state of alarm was declared. The Psychiatry Service applied a contingency plan which included the reorganization of the human resources, the closure of some of the units and the implementation of telemedicine programs along with two specific programs, namely a mental health assistance program in the context of the infection by coronavirus, and another program for homeless people. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329660PMC

Graphene nanoribbons: A promising nanomaterial for biomedical applications.

J Control Release 2020 Jul 2. Epub 2020 Jul 2.

College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode 673008, Kerala, India. Electronic address:

Graphene nanoribbons (GNRs) are narrow lengthened strips of single-layer graphene. Among the graphene family of nanomaterials, GNRs are remarkable materials due to their attractive physical, chemical, electrical, mechanical, thermal, and optical properties. They have an ultra-high surface area. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.06.034DOI Listing

Digitalization, clinical microbiology and infectious diseases.

Authors:
Adrian Egli

Clin Microbiol Infect 2020 Jul 2. Epub 2020 Jul 2.

Clinical Bacteriology and Mycology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland; Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cmi.2020.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330545PMC

The determination of release from isolation of COVID-19 patients requires ultra-high sensitivity nucleic acid test technology.

J Infect 2020 Jul 2. Epub 2020 Jul 2.

Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Centre for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2020.06.075DOI Listing

Thoracic duct lymphatic fluid harbors phenotypically naive T cells for use in adoptive T-cell therapy.

Cytotherapy 2020 Jul 1. Epub 2020 Jul 1.

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Background Aims: Manufacturing of potent chimeric antigen receptor (CAR) T cells requires phenotypically naive and early memory T cells. We hypothesized lymphatic fluid collected from the thoracic duct of children would serve as a unique reservoir for early T cells, which could then be used for CAR T-cell therapy.

Methods: We evaluated lymphatic fluid collected from 25 pediatric patients undergoing thoracic duct cannulation for other clinical indications. Read More

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http://dx.doi.org/10.1016/j.jcyt.2020.05.004DOI Listing

Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.

Mayo Clin Proc 2020 Jul 19;95(7):1445-1453. Epub 2020 May 19.

Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy.

Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236707PMC

Novel decision algorithm to discriminate parkinsonism with combined blood and imaging biomarkers.

Parkinsonism Relat Disord 2020 Jun 22;77:57-63. Epub 2020 Jun 22.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:

Introduction: To determine an exploratory multimodal approach including serum NFL and MR planimetric measures to discriminate Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP).

Methods: MR planimetric measurements and NFL serum levels, with a mean time interval of 60 months relative to symptom onset, were assessed in a retrospective cohort of 11 progressive supranuclear palsy (PSP), 22 Parkinson's disease (PD), 16 multiple system atrophy (MSA) patients and 42 healthy controls (HC). A decision tree model to discriminate PD, PSP, and MSA was constructed using receiver operating characteristic curve analysis and Classification and Regression Trees algorithm. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.05.033DOI Listing

Targeted co-delivery of curcumin and doxorubicin by citric acid functionalized Poly (ε-caprolactone) based micelle in MDA-MB-231 cell.

Colloids Surf B Biointerfaces 2020 Jun 26;194:111225. Epub 2020 Jun 26.

Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

This study aimed to design an effective targeted combination of doxorubicin (Dox)-Curcumin (Cur) delivery system to eradicate the MDA-MB231 cell line. A novel biodegradable poly ε-Caprolactone-co-maleic anhydride-graft-citric acid copolymer micelle (PCL-co-P(MA-g-CA)) was synthesized through thiolen radical copolymerization and ring-opening polymerization. The unique micelle structure allowed simultaneous loading of hydrophilic Dox and hydrophobic Cur with a loading efficiency of above 98 % for each drug. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111225DOI Listing

Study of the neurotoxicity of indoor airborne nanoparticles based on a 3D human blood-brain barrier chip.

Environ Int 2020 Jul 1;143:105598. Epub 2020 Jul 1.

Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China; Hubei Key Laboratory for Processing and Transformation of Agricultural Products, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, PR China. Electronic address:

Background: There is growing public awareness regarding the health effects of indoor nanoscale particulate matter (INPM) since people spend the majority of their time indoors. INPM could have a direct entry route into the brain via the axons of the olfactory nerve and migrating across the blood-brain barrier (BBB). Using animals to explore this possibility is not a reliable method to fully demonstrate human physiological responses. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105598DOI Listing

Gastrointestinal Alterations in Autism Spectrum Disorder: What Do We Know?

Neurosci Biobehav Rev 2020 Jul 1. Epub 2020 Jul 1.

CONEM Egypt Child Brain Research Group, National Research Centre, Giza, Egypt; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy; CONEM Scientific Secretary, Verona, Italy.

There is an emerging body of evidence associating children having autism spectrum disorder (ASD) with gastrointestinal (GI) symptoms, such as abdominal pain, chronic diarrhea, constipation, vomiting, gastroesophageal reflux, intestinal infections, and increased intestinal permeability. Moreover, in many studies, large differences in the composition of intestinal microbiota and metabolic products between ASD patients and controls were reported. Deepening the role and the biology of the gut microbiome may be fundamental to elucidate the onset of GI symptoms in ASD individuals and their etiopathogenetic causes. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2020.06.033DOI Listing

Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity.

J Pharm Sci 2020 Jul 1. Epub 2020 Jul 1.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, UK. Electronic address:

Latent and active levels of cerebral matrix metalloproteinase 9 (MMP-9) are elevated in neurological diseases and brain injuries, contributing to neurological damage and poor clinical outcomes. This study aimed developing peptide-based nanoparticles with ability to cross the blood-brain-barrier (BBB) and inhibit MMP-9. Three amphiphilic peptides were synthesised containing brain-targeting ligands (HAIYPRH or CKAPETALC) conjugated with MMP-9 inhibiting peptide (CTTHWGFTLC) linked by glycine (spacer) at the N-terminus, and the peptide sequences were conjugated at the N- terminus to cholesterol. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.06.021DOI Listing

A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Atorvastatin for Nephrogenic Diabetes Insipidus in Lithium-Users.

Bipolar Disord 2020 Jul 4. Epub 2020 Jul 4.

Geri-PARTy Research Group, Jewish General Hospital, Montreal, Canada.

Objective: Lithium remains an important treatment for mood disorders but is associated with kidney disease. Nephrogenic diabetes insipidus (NDI) is associated with up to 3-fold risk of incident chronic kidney disease amongst lithium users. There is limited randomized controlled trials (RCT) for treatments of lithium-induced NDI, and existing therapies can be poorly tolerated. Read More

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http://dx.doi.org/10.1111/bdi.12973DOI Listing

Clinical correlates of rhinovirus infection in preschool asthma.

Allergy 2020 Jul 3. Epub 2020 Jul 3.

Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.

Background: Investigation of preschool asthma is important since not all children outgrow their illness during this age. Data are scarce on the role of rhinovirus (RV) infections in this patient group.

Objectives: To investigate the role of RV infections in preschool asthma: (1) susceptibility factors, (2) clinical course, and (3) medium-term outcome. Read More

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http://dx.doi.org/10.1111/all.14479DOI Listing

Skin color and vitamin D: an update.

Exp Dermatol 2020 Jul 3. Epub 2020 Jul 3.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211, Kuopio, Finland.

Homo sapiens evolved in East Africa and had dark skin, hair and eyes, in order to protect against deleterious consequences of intensive UV radiation at equatorial latitudes. Intensive skin pigmentation was thought to bear the risk of inefficient vitamin D synthesis in the skin. This initiated the hypothesis that within the past 75,000 years, in which humans migrated to higher latitudes in Asia and Europe, the need for vitamin D synthesis served as an evolutionary driver for skin lightening. Read More

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http://dx.doi.org/10.1111/exd.14142DOI Listing

Erythropoietin-Modified Mesenchymal Stem Cells Enhance Anti-fibrosis Efficacy in Mouse Liver Fibrosis Model.

Tissue Eng Regen Med 2020 Jul 3. Epub 2020 Jul 3.

National Guizhou Joint Engineering Laboratory for Cell Engineering and Biomedicine Technique/Center for Tissue Engineering and Stem Cell Research/Guizhou Province Key Laboratory of Regenerative Medicine, Guizhou Medical University, Beijing Road 9, Guiyang, 550004, Guizhou Province, China.

Background: Mesenchymal stem cell (MSC)-based cell transplantation is an effective means of treating chronic liver injury, fibrosis and end-stage liver disease. However, extensive studies have found that only a small number of transplanted cells migrate to the site of injury or lesion, and repair efficacy is very limited.

Methods: Bone marrow-derived MSCs (BM-MSCs) were generated that overexpressed the erythropoietin (EPO) gene using a lentivirus. Read More

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http://dx.doi.org/10.1007/s13770-020-00276-2DOI Listing

Physical activity for people living with dementia: carer outcomes and side effects from the perspectives of professionals and family carers.

Aging Clin Exp Res 2020 Jul 3. Epub 2020 Jul 3.

Respiratory Research and Rehabilitation Laboratory (Lab3R), School of Health Sciences (ESSUA) and Institute for Research in Biomedicine (iBiMED), University of Aveiro, Agras do Crasto, Campus Universitário de Santiago, Building 30, 3810-193, Aveiro, Portugal.

Background: Adherence to physical activity is challenging for people living with dementia, and largely dependent on carers' involvement. Carers are likely to support physical activity based on their perceived balance between benefits and potential side effects of such intervention for both patients and themselves. Professionals also have a role in terms of optimising such interventions not only for people with dementia but also their carers. Read More

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http://dx.doi.org/10.1007/s40520-020-01636-7DOI Listing

Validity of traditional physical activity intensity calibration methods and the feasibility of self-paced walking and running on individualised calibration of physical activity intensity in children.

Sci Rep 2020 Jul 3;10(1):11031. Epub 2020 Jul 3.

Biology of Physical Activity, Faculty of Sport and Health Sciences, University of Jyväskylä, PO Box 35, 40014, Jyväskylä, Finland.

There are no practical and valid methods for the assessment of individualised physical activity (PA) intensity in observational studies. Therefore, we investigated the validity of commonly used metabolic equivalent of tasks (METs) and pre-determined PA intensity classification methods against individualised PA intensity classification in 35 children 7-11-years-of-age. Then, we studied validity of mean amplitude deviation (MAD) measured by accelerometry during self-paced walking and running in assessment of individualised PA intensity. Read More

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http://dx.doi.org/10.1038/s41598-020-67983-7DOI Listing

Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1.

Sci Rep 2020 Jul 3;10(1):11017. Epub 2020 Jul 3.

Department of Physiology, Emory University School of Medicine, Atlanta, GA, 30322, USA.

The previous reports on an addiction vulnerability marker in the human SLC4A7 gene encoding the Na/HCO transporter NBCn1 suggest that this pH-regulating protein may affect alcohol-related behavior and response. Here, we examined alcohol consumption and sensitivity to the sedative effects of alcohol in male NBCn1 knockout mice. These mice displayed lower pH in neurons than wildtype controls, determined by intracellular pH in hippocampal neuronal cultures. Read More

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http://dx.doi.org/10.1038/s41598-020-67291-0DOI Listing

Germline de novo mutation rates on exons versus introns in humans.

Nat Commun 2020 Jul 3;11(1):3304. Epub 2020 Jul 3.

Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193, Barcelona, Spain.

A main assumption of molecular population genetics is that genomic mutation rate does not depend on sequence function. Challenging this assumption, a recent study has found a reduction in the mutation rate in exons compared to introns in somatic cells, ascribed to an enhanced exonic mismatch repair system activity. If this reduction happens also in the germline, it can compromise studies of population genomics, including the detection of selection when using introns as proxies for neutrality. Read More

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http://dx.doi.org/10.1038/s41467-020-17162-zDOI Listing

Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways.

Nat Commun 2020 Jul 3;11(1):3285. Epub 2020 Jul 3.

Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800, Lyngby, Denmark.

The early life human gut microbiota exerts life-long health effects on the host, but the mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of Clostridiales from the Roseburia-Eubacterium group, associated with protection from colorectal cancer, immune- and metabolic disorders is enigmatic. Here, we describe catabolic pathways that support the growth of Roseburia and Eubacterium members on distinct human milk oligosaccharides (HMOs). Read More

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http://dx.doi.org/10.1038/s41467-020-17075-xDOI Listing

Upgrading ketone synthesis direct from carboxylic acids and organohalides.

Nat Commun 2020 Jul 3;11(1):3312. Epub 2020 Jul 3.

State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.

The ketone functional group has a unique reactivity in organic chemistry and is associated with a number of useful reactions. Catalytic methods for ketone synthesis are continually being developed. Here, we report a photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of commercially available chemicals, aromatic acids and aryl/alkyl bromides. Read More

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http://dx.doi.org/10.1038/s41467-020-17224-2DOI Listing

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.

Nat Commun 2020 Jul 3;11(1):3344. Epub 2020 Jul 3.

Division of Hematology/Oncology, Department of Pediatrics, Stanford University, Stanford, CA, 94305, USA.

Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome associated with ribosomal gene mutations that lead to ribosomal insufficiency. DBA is characterized by anemia, congenital anomalies, and cancer predisposition. Treatment for DBA is associated with significant morbidity. Read More

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http://dx.doi.org/10.1038/s41467-020-17100-zDOI Listing

MicroRNAs Associated With Biological Pathways of Left- and Right-sided Colorectal Cancer.

Anticancer Res 2020 Jul;40(7):3713-3722

School of Medicine, Institute of Clinical Medicine, Clinical Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

Background/aim: MicroRNAs (miRNAs) regulate the development of colorectal cancer (CRC). We aimed to investigate miRNAs and their relation to cancer-related signaling pathways in site-specific CRC.

Materials And Methods: We used a total of 24 left- and right-sided Finnish CRC samples (discovery cohort) and The Cancer Genome Atlas public mature miRSeq dataset of 201 CRC samples (validation cohort). Read More

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http://dx.doi.org/10.21873/anticanres.14360DOI Listing

Transcranial magnetic stimulation and gait disturbances in Parkinson's disease: A systematic review.

Neurophysiol Clin 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurorehabilitation, Hospital of Vipiteno, Vipiteno, Italy; Research Unit for Neurorehabilitation South Tyrol, Bolzano, Italy.

Transcranial magnetic stimulation (TMS) may offer a reliable means of characterizing important pathophysiologic aspects of motor impairments in Parkinson's disease (PD). Moreover, high-frequency repetitive TMS (rTMS), especially if delivered bilaterally over motor cortical regions, can have beneficial effects on parkinsonian motor symptoms. However, only a few studies have investigated the effects of rTMS on freezing of gait (FOG) and other gait disturbances in PD. Read More

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http://dx.doi.org/10.1016/j.neucli.2020.05.002DOI Listing

From Raw Data to FAIR Data: The FAIRification Workflow for Health Research.

Methods Inf Med 2020 Jun 3;59(S 01):e21-e32. Epub 2020 Jul 3.

Group of Research and Innovation in Biomedical Informatics, Biomedical Engineering and Health Economy, Institute of Biomedicine of Seville/Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain.

Background:  FAIR (findability, accessibility, interoperability, and reusability) guiding principles seek the reuse of data and other digital research input, output, and objects (algorithms, tools, and workflows that led to that data) making them findable, accessible, interoperable, and reusable. GO FAIR - a bottom-up, stakeholder driven and self-governed initiative - defined a seven-step FAIRification process focusing on data, but also indicating the required work for metadata. This FAIRification process aims at addressing the translation of raw datasets into FAIR datasets in a general way, without considering specific requirements and challenges that may arise when dealing with some particular types of data. Read More

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http://dx.doi.org/10.1055/s-0040-1713684DOI Listing

A light on the dark side: in vivo endoscopic anatomy of the posterior third ventricle and its variations in hydrocephalus.

J Neurosurg 2020 Jul 3:1-9. Epub 2020 Jul 3.

2Department of Neurosciences, Neurosurgical Unit, University of Modena.

Objective: Despite the technological advancements of neurosurgery, the posterior part of the third ventricle has always been the "dark side" of the ventricle. However, flexible endoscopy offers the opportunity for a direct, in vivo inspection and detailed description of the posterior third ventricle in physiological and pathological conditions. The purposes of this study were to describe the posterior wall of the third ventricle, detailing its normal anatomy and surgical landmarks, and to assess the effect of chronic hydrocephalus on the anatomy of this hidden region. Read More

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http://dx.doi.org/10.3171/2020.4.JNS20493DOI Listing