574,847 results match your criteria Biomedical research Tokyo Japan[Journal]


Re: Understanding quality of life impact in people with retinal vein occlusion: a qualitative inquiry.

Clin Exp Optom 2019 Apr 24. Epub 2019 Apr 24.

School of Medicine, Dentistry and Biomedical Science, Queen's University of Belfast, Belfast, UK.

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http://dx.doi.org/10.1111/cxo.12906DOI Listing

Quality Informatics: The Convergence of Healthcare Data, Analytics, and Clinical Excellence.

Appl Clin Inform 2019 Mar 24;10(2):272-277. Epub 2019 Apr 24.

Warren Alpert Medical School and Center for Biomedical Informatics, Brown University, Rhode Island, United States.

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http://dx.doi.org/10.1055/s-0039-1685221DOI Listing

Preoperative Considerations in Occipital Artery-high-riding Posterior Inferior Cerebellar Artery Bypass: A Report of Two Cases and a Literature Review.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Chonnam Nat' University Medical School and Hospital, Gwangju, Korea, Republic of.

Nonsaccular vertebral artery aneurysms involving the posterior inferior cerebellar artery (PICA) are rare. Treatment is considered a significant challenge because of their angiographic and anatomical features, especially in high-riding PICA. Therefore, meticulous preoperative angiographic and anatomical evaluation is necessary. Read More

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http://dx.doi.org/10.1055/s-0039-1684025DOI Listing

Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.

Skin Pharmacol Physiol 2019 Apr 24;32(3):162-172. Epub 2019 Apr 24.

Institute for Translational Wound Research, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany.

Background: The number of patients who has a daily intake of antihypertensive drugs is rising, due to an also rising prevalence of lifestyle diseases. Interestingly, knowledge about effects of these drugs in terms of wound healing is low.

Objective: Based on a few differing studies, the idea arose that antihypertensives may have side effects on wound healing. Read More

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http://dx.doi.org/10.1159/000499433DOI Listing
April 2019
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The rise of bottom-up synthetic biology and cell-free biology.

Authors:
Allen P Liu

Phys Biol 2019 Apr 24. Epub 2019 Apr 24.

Mechanical Engineering, Biomedical Engineering, Cell and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, UNITED STATES.

No abstract. Read More

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http://dx.doi.org/10.1088/1478-3975/ab1bedDOI Listing

Performance comparison of depth-encoding detectors based on dual-ended readout and different SiPMs for high-resolution PET applications.

Phys Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Biomedical Engineering, University of California - Davis, One Shields Avenue, Davis, California, 95616, UNITED STATES.

Silicon photomultipliers (SiPMs) are widely used in positron emission tomography (PET), however, SiPMs from different vendors vary in their performance characteristics. In addition, the specifications provided by the manufacturers are measured under different operating conditions and using different test setups, making it difficult to choose the optimal device for a specific application using the published specifications. In this work, we evaluated four state-of-the-art 8 × 8 arrays of ~ 3 mm × 3 mm SiPMs from SensL, KETEK, and Hamamatsu for high-resolution dual-ended readout detectors using the same experimental setup and procedures. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c37DOI Listing

Glucoregulatory activity of Vesiculin in insulin sensitive and resistant mice.

Peptides 2019 Apr 21. Epub 2019 Apr 21.

School of Biological Sciences, New Zealand; Maurice Wilkins Centre for Molecular BioDiscovery, Auckland, New Zealand; Centre for Advanced Discovery and Experimental Therapeutics, Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, and the School of Biomedicine, the Medical School, University of Manchester, Manchester M13 9WL, UK.

Pancreatic islet-derived peptide hormones play key roles in the maintenance of systemic energy homeostasis and glucose balance, and defects in their regulation are strongly implicated in the pathogenesis of obesity and diabetes. Peptides have also been used as lead compounds for therapeutics targeting metabolic disease. It is therefore important to understand the activity and function of islet hormones in both their target tissues and the whole organism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193004
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http://dx.doi.org/10.1016/j.peptides.2019.04.011DOI Listing
April 2019
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Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease.

Free Radic Biol Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Chemistry, University of Patras, Rion 26504, Greece. Electronic address:

Multiple thioredoxin isoforms exist in all living cells. To explore the possible functions of mammalian mitochondrial thioredoxin 2 (Trx2), an interactome of mouse Trx2 was initially created using (i) a monothiol mouse Trx2 species for capturing protein partners from different organs and (ii) yeast two hybrid screens on human liver and rat brain cDNA libraries. The resulting interactome consisted of 195 proteins (Trx2 included) plus the mitochondrial 16S RNA. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.018DOI Listing

Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity.

Mol Cell Endocrinol 2019 Apr 21. Epub 2019 Apr 21.

School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Perth, Western Australia, 6845, Australia. Electronic address:

Studies have reported that plasma glutamine is reduced in type 2 diabetes (T2D) patients. Glutamine supplementation improves glycaemic control, however the mechanisms are unclear. Here, we evaluated in vitro the pancreatic beta cell bioenergetic and insulin secretory responses to various levels of glutamine availability, or treatment in the presence of an inhibitor of intracellular glutamine metabolism. Read More

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http://dx.doi.org/10.1016/j.mce.2019.04.013DOI Listing

Notch Signaling Mediates Secondary Senescence.

Cell Rep 2019 Apr;27(4):997-1007.e5

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK. Electronic address:

Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.104DOI Listing

Direct Lung Sampling Indicates That Established Pathogens Dominate Early Infections in Children with Cystic Fibrosis.

Cell Rep 2019 Apr;27(4):1190-1204.e3

Department of Microbiology and Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address:

Culture and sequencing have produced divergent hypotheses about cystic fibrosis (CF) lung infections. Culturing suggests that CF lungs are uninfected before colonization by a limited group of CF pathogens. Sequencing suggests diverse communities of mostly oral bacteria inhabit lungs early on and diversity decreases as disease progresses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193042
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http://dx.doi.org/10.1016/j.celrep.2019.03.086DOI Listing
April 2019
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Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D.

Cell Rep 2019 Apr;27(4):1151-1164.e5

Department of Biology, Tufts University, Suite 4700, 200 Boston Ave., Medford, MA 02155, USA; Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA. Electronic address:

Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cells. Flex1 fragility is dependent on the ability of a variable-length AT repeat to form a cruciform structure that stalls replication. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.103DOI Listing

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination.

Cell Rep 2019 Apr;27(4):1090-1102.e10

Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden; Ming Wai Lau Centre for Reparative Medicine, Stockholm Node, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address:

Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of citrullination has been suggested as a therapeutic strategy for MS. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.108DOI Listing

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.

Cell Rep 2019 Apr;27(4):1018-1026.e4

The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, Edinburgh EH25 9RG, UK; Euan MacDonald Centre, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Centre for Dementia Prevention, University of Edinburgh, 9A Bioquarter, 9 Little France Road, Edinburgh EH16 4UX, UK. Electronic address:

Normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified this morphologically, the molecular pathways orchestrating preferential synaptic vulnerability remain to be elucidated. Using quantitative proteomics and healthy rhesus macaque and human patient brain regional tissues, we have comprehensively profiled the temporal expression of the synaptic proteome throughout the adult lifespan in differentially vulnerable brain regions. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.096DOI Listing

Molecular aspects of signalling in diabesity.

Mol Aspects Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2019.04.003DOI Listing

Heterozygosity mapping for human dominant trait variants.

Hum Mutat 2019 Apr 24. Epub 2019 Apr 24.

Laboratory of Statistical Genetics, Rockefeller University, New York, New York.

Homozygosity mapping is a well-known technique to identify runs of homozygous variants that are likely to harbor genes responsible for autosomal recessive disease, but a comparable method for autosomal dominant traits has been lacking. We developed an approach to map dominant disease genes based on heterozygosity frequencies of sequence variants in the immediate vicinity of a dominant trait. We demonstrate through theoretical analysis that DNA variants surrounding an inherited dominant disease variant tend to have increased heterozygosity compared with variants elsewhere in the genome. Read More

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http://dx.doi.org/10.1002/humu.23765DOI Listing

Enzyme-Instructed Self-Assembly (EISA) and Hydrogelation of Peptides.

Adv Mater 2019 Apr 24:e1805798. Epub 2019 Apr 24.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, National Institute for Advanced Materials, and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, P. R. China.

Self-assembly is a powerful tool for constructing supramolecular materials for many applications, ranging from energy harvesting to biomedicine. Among the methods to prepare supramolecular materials for biomedical applications, enzyme-instructed self-assembly (EISA) has several advantages. Herein, the unique properties and advantages of EISA in preparing biofunctional supramolecular nanomaterials and hydrogels from peptides are highlighted. Read More

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http://dx.doi.org/10.1002/adma.201805798DOI Listing

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.

PLoS Pathog 2019 Apr 24;15(4):e1007709. Epub 2019 Apr 24.

Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed that protective STAT1 signaling controls viral replication and pathogenesis, but the immune mechanisms that noroviruses exploit to induce pathology are elusive. Here, we show that gastrointestinal MNV infection leads to widespread IL-1β maturation in MNV-susceptible STAT1-deficient mice. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007709DOI Listing

Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia.

PLoS One 2019 24;14(4):e0216162. Epub 2019 Apr 24.

Department of Medical and Surgical Sciences and Advanced Technology, Section of Neurosciences, University of Catania, Catania, Italy.

Background: Although cerebral white matter lesions (WMLs) are considered as a risk factor for vascular dementia, data on their impact on cerebral hemodynamics are scarce. We test and compare transcranial Doppler (TCD) features in WML patients with or without associated cognitive impairment.

Methods: A sample of non-demented elderly patients with WMLs was consecutively recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216162PLOS

Mentoring stages: A study of undergraduate mentoring in palliative medicine in Singapore.

PLoS One 2019 24;14(4):e0214643. Epub 2019 Apr 24.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

Background: Mentoring nurtures a mentee's personal and professional development. Yet conflation of mentoring approaches and a failure to contend with mentoring's nature makes it difficult to study mentoring processes and relationships. This study aims to understand of mentee experiences in the Palliative Medicine Initiative (PMI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214643PLOS

Comparative evaluation of cerebral gliomas using rCBV measurements during sequential acquisition of T1-perfusion and T2*-perfusion MRI.

PLoS One 2019 24;14(4):e0215400. Epub 2019 Apr 24.

Philips Health Tech Asia Pacific, Minato-ku Tokyo, Japan.

Objective: To assess the inter-technique agreement of relative cerebral blood volume (rCBV) measurements obtained using T1- and T2*-perfusion MRI on 3T scanner in glioma patients.

Methods: A total of 49 adult patients with gliomas underwent both on T1- and T2*-perfusion in the same scanning session, and rCBV maps were estimated using both methods. For the quantitative analysis; Two independent observers recorded the rCBV values from the tumor as well as contralateral brain tissue from both T1- and T2*-perfusion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215400PLOS

The match-play sprint performance of elite senior hurlers during competitive games.

PLoS One 2019 24;14(4):e0215156. Epub 2019 Apr 24.

Faculty of Health and Science, Department of Science and Technology, University of Suffolk, Ipswich, United Kingdom.

The typical sprint profile in elite hurling has yet to be established. The purpose of this study was to investigate the sprinting demands of elite hurling competition and characterize the sprinting patterns of different playing positions. GPS (10-Hz, STATSports Viper) were used to collect data from 51 hurlers during 18 games. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215156PLOS

CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties.

PLoS Genet 2019 Apr 24;15(4):e1008034. Epub 2019 Apr 24.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian hair follicle (HF) responsible for recurrent generation of a large number of differentiated melanocytes during each HF cycle. HF McSCs reside in both the CD34+ bulge/lower permanent portion (LPP) and the CD34- secondary hair germ (SHG) regions of the HF during telogen. Using Dct-H2BGFP mice, we separate bulge/LPP and SHG McSCs using FACS with GFP and anti-CD34 to show that these two subsets of McSCs are functionally distinct. Read More

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http://dx.plos.org/10.1371/journal.pgen.1008034
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http://dx.doi.org/10.1371/journal.pgen.1008034DOI Listing
April 2019
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Prolonged time course of population excitatory postsynaptic potentials in motoneurons of chronic stroke survivors.

J Neurophysiol 2019 Apr 24. Epub 2019 Apr 24.

research, Northwestern University, United States.

Hyperexcitability of spinal motoneurons may contribute to muscular hypertonia after hemispheric stroke. The origins of this hyperexcitability are not clear, but we hypothesized that prolongation of the Ia excitatory postsynaptic potential (EPSP) in spastic motoneurons may be one potential mechanism, by enabling more effective temporal summation of Ia EPSPs, making action potential initiation easier. Thus, the purpose of this study is to quantify the time-course of putative EPSPs in spinal motoneurons of chronic stroke survivors. Read More

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http://dx.doi.org/10.1152/jn.00288.2018DOI Listing

Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 24. Epub 2019 Apr 24.

Florida Atlantic University, United States.

In addition to skeletal muscle dysfunction, cancer cachexia is a systemic disease involving remodeling of non-muscle organs such as adipose and liver. Impairment of mitochondrial function is associated with multiple chronic diseases. The tissue-specific control of mitochondrial function in cancer cachexia is not well-defined. Read More

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http://dx.doi.org/10.1152/ajpregu.00028.2019DOI Listing

Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model.

FASEB J 2019 Apr 24:fj201802711R. Epub 2019 Apr 24.

Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Osteoporosis is a major health problem, making bones fragile and susceptible to fracture. Previous works showed that mechanical loading stimulated bone formation and accelerated fracture healing. Focusing on the role of Wnt3a (wingless/integrated 3a), this study was aimed to assess effects of mechanical loading to the spine, using ovariectomized (OVX) mice as a model of osteoporosis. Read More

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http://dx.doi.org/10.1096/fj.201802711RDOI Listing

Matrix stiffness regulates microvesicle-induced fibroblast activation.

Am J Physiol Cell Physiol 2019 Apr 24. Epub 2019 Apr 24.

Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States.

Extracellular vesicles released by cancer cells have recently been implicated in the differentiation of stromal cells to their activated, cancer-supporting states. Microvesicles, a subset of extracellular vesicles released from the plasma membrane of cancer cells, contain biologically active cargo, including DNA, mRNA, and miRNA, which are transferred to recipient cells and induce a phenotypic change in behavior. While it is known that microvesicles can alter recipient cell phenotype, little is known about how the physical properties of the tumor microenvironment affect fibroblast response to microvesicles. Read More

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http://dx.doi.org/10.1152/ajpcell.00418.2018DOI Listing
April 2019
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Chemoselective Synthesis of N-Terminal Cysteinyl Thioesters via β,γ-C,S Thiol-Michael Addition.

Org Lett 2019 Apr 24. Epub 2019 Apr 24.

School of Chemistry and Trinity Biomedical Sciences Institute (TBSI) , Trinity College Dublin, The University of Dublin , Dublin 2 , Ireland.

Dehydroalanine (ΔAla) is a highly electrophilic residue that can react efficiently with sulfur nucleophiles to furnish cysteinyl analogues. Herein, we report an efficient synthesis of N-terminal cysteinyl thioesters, suitable for S, N-acyl transfer, based on β,γ-C,S thiol-Michael addition. Both ionic and radical-based methodologies were found to be efficient for this process. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01013DOI Listing

Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins.

J Proteome Res 2019 Apr 24. Epub 2019 Apr 24.

Department of Molecular and Biomedical Sciences , Jožef Stefan Institute , Jamova cesta 39 , SI-1000 Ljubljana , Slovenia.

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes ( Vaa), in particular, is, medically, one of the most relevant snakes in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and nonenzymatic venom components acting, most prominently, on the blood, cardiovascular, and nerve systems. This venom is a very complex mixture of pharmacologically active proteins and peptides. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00120DOI Listing

Pharmacological modulation of the spatiotemporal disposition of micromotions in the intact resting urinary bladder of the rabbit; their pattern is under both myogenic and autonomic control.

BJU Int 2019 Apr 24. Epub 2019 Apr 24.

Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand.

Objectives: To explore and characterize the disposition and dynamics of micromotions in the wall of the intact resting teradotoxinized urinary bladder of the rabbit before and after the administration of adrenergic and cholinergic pharmaceutical agents.

Methods: Spatiotemporal maps and related intravesical pressure were used to analyse propagating patches of contractions (PPCs) and their component individual myogenic contractions [propagating individual contractions (PICs)] in the wall of the tetradotoxinized urinary bladder.

Results: The bladder wall exhibited two contractile states that were of similar frequencies to those of the two types of electrophysiological discharge described in previous studies; the first, in which cyclic PPCs predominated, the second in which small irregular PICs predominated. Read More

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http://dx.doi.org/10.1111/bju.14715DOI Listing

Outcomes of Pancreaticoduodenctomy in Patients with Chronic Hepatic Dysfunction Including Liver Cirrhosis: Results of a Retrospective Multicenter Study by the Japanese.

J Hepatobiliary Pancreat Sci 2019 Apr 24. Epub 2019 Apr 24.

Second Department of Surgery, Wakayama Medical University School of Medicine.

Purpose: Since there is no reliable evidence on the safety of pancreaticoduodenectomy (PD) in chronic hepatic dysfunction (CHD) including liver cirrhosis (LC), the effects of CHD on patients undergoing PD were investigated.

Methods: This multi-institutional retrospective study analyzed 529 patients with CHD, including 105 patients diagnosed with LC, who underwent PD at 82 high-volume institutions between 2004 and 2013.

Results: The in-hospital mortality rate was 5. Read More

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http://dx.doi.org/10.1002/jhbp.630DOI Listing

Development and radiosynthesis of the first F-labeled inhibitor of monocarboxylate transporters (MCTs).

J Labelled Comp Radiopharm 2019 Apr 24. Epub 2019 Apr 24.

Institute of Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Research Site Leipzig, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.

Monocarboxylate transporters 1 and 4 (MCT1 and MCT4) are involved in tumor development and progression. Their expression levels are related to clinical disease prognosis. Accordingly, both MCTs are promising drug targets for treatment of a variety of human cancers. Read More

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http://dx.doi.org/10.1002/jlcr.3739DOI Listing

The Austrian UVA-Network.

Photochem Photobiol 2019 Apr 24. Epub 2019 Apr 24.

Medical University Innsbruck, Div. of Biomedical Physics, Austria.

The ultraviolet-A (UVA) part of the solar spectrum at the Earth's surface is an essential environmental factor but continuous long-time monitoring of UVA radiation is rarely done. In Austria, three existing stations of the UV monitoring network have been upgraded with UVA broadband instruments. At each station, one instrument measures global UVA irradiance and - in parallel - a second instrument measures diffuse irradiance. Read More

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http://dx.doi.org/10.1111/php.13111DOI Listing

Usage Patterns of GlucoNote, a Self-Management Smartphone App, Based on ResearchKit for Patients With Type 2 Diabetes and Prediabetes.

JMIR Mhealth Uhealth 2019 Apr 24;7(4):e13204. Epub 2019 Apr 24.

Department of Biomedical Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Preventing progression from prediabetes to diabetes-or slowing the progression of diabetes-is an urgent task worldwide. Previous studies have shown that mobile health (mHealth) may powerfully support self-management for patients with type 2 diabetes. Certainly, mHealth improves health care efficiency and gives patients convenient access to self-management of their own health. Read More

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http://mhealth.jmir.org/2019/4/e13204/
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http://dx.doi.org/10.2196/13204DOI Listing
April 2019
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Detecting Developmental Delay and Autism Through Machine Learning Models Using Home Videos of Bangladeshi Children: Development and Validation Study.

J Med Internet Res 2019 Apr 24;21(4):e13822. Epub 2019 Apr 24.

Division of Systems Medicine, Department of Pediatrics, Stanford University, Palo Alto, CA, United States.

Background: Autism spectrum disorder (ASD) is currently diagnosed using qualitative methods that measure between 20-100 behaviors, can span multiple appointments with trained clinicians, and take several hours to complete. In our previous work, we demonstrated the efficacy of machine learning classifiers to accelerate the process by collecting home videos of US-based children, identifying a reduced subset of behavioral features that are scored by untrained raters using a machine learning classifier to determine children's "risk scores" for autism. We achieved an accuracy of 92% (95% CI 88%-97%) on US videos using a classifier built on five features. Read More

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http://dx.doi.org/10.2196/13822DOI Listing

How Do Pharmaceutical Companies Model Survival of Cancer Patients? A Review of NICE Single Technology Appraisals in 2017.

Int J Technol Assess Health Care 2019 Jan;35(2):160-167

Warwick Evidence,Warwick Medical School,University of Warwick.

Objectives: Before an intervention is publicly funded within the United Kingdom, the cost-effectiveness is assessed by the National Institute of Health and Care Excellence (NICE). The efficacy of an intervention across the patients' lifetime is often influential of the cost-effectiveness analyses, but is associated with large uncertainties. We reviewed committee documents containing company submissions and evidence review group (ERG) reports to establish the methods used when extrapolating survival data, whether these adhered to NICE Technical Support Document (TSD) 14, and how uncertainty was addressed. Read More

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http://dx.doi.org/10.1017/S0266462319000175DOI Listing
January 2019

Characterization of Intracellular Peptides from Zebrafish () Brain.

Zebrafish 2019 Apr 24. Epub 2019 Apr 24.

1 Bioscience Institute, São Paulo State University, São Vicente, Brazil.

Peptides represent a large class of cell signaling molecules, and they are mainly produced by the classical secretory pathway or during protein degradation. The peptide profile of (zebrafish) shows a lack of information when compared with other consolidated animal models. The aim of this work was to characterize the peptide profile of zebrafish brain by using triplex reductive methylation of amines labeling and liquid chromatography coupled to electron spray mass spectrometry. Read More

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https://www.liebertpub.com/doi/10.1089/zeb.2018.1718
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http://dx.doi.org/10.1089/zeb.2018.1718DOI Listing
April 2019
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Evaluating the Effects of Various Decalcification Protocols on Immunohistochemical Staining in Zebrafish ().

Zebrafish 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon.

Fixation and decalcification can alter protein structure in tissues, influencing the efficacy of primary antibodies routinely used in immunohistochemical (IHC) staining. Histologic examination of zebrafish requires both processes, making staining and analysis potentially challenging. Here, we investigated the effects of common fixation and decalcification protocols on IHC staining in zebrafish. Read More

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http://dx.doi.org/10.1089/zeb.2018.1697DOI Listing

Automatic localization of anatomical regions in medical ultrasound images of rheumatoid arthritis using deep learning.

Proc Inst Mech Eng H 2019 Apr 24:954411919845747. Epub 2019 Apr 24.

3 Department of Biomedical Engineering, Vels Institute of Science, Technology and Advanced Studies, Chennai, India.

The pace of population aging is growing faster worldwide. The quality of life of the aging population is mostly affected by rheumatic diseases. With the increasing rate of rheumatoid arthritis in the aging population, technological advances in the field of automatic image processing and analysis have paved way for automatic detection and diagnosis of arthritis based on how the grade of the synovial region is designed. Read More

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http://dx.doi.org/10.1177/0954411919845747DOI Listing

Implication of the whitefly, , collagen protein in begomoviruses acquisition and transmission.

Phytopathology 2019 Apr 24. Epub 2019 Apr 24.

University of Delhi, 28742, Gut Biology Laboratory, Room No. 117, Department of Zoology, Delhi, Delhi, India ;

Begomoviruses are the largest group of plant viruses, transmitted exclusively by the whitefly, (Gennadius) in a persistent, circulative and non-propagative manner. Begomoviruses, in association with cause enormous loss to world agricultural crops. Transmission, retention and circulation of begomovirus in are facilitated by its interaction with several proteins of the insect and its endosymbionts. Read More

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http://dx.doi.org/10.1094/PHYTO-03-18-0082-RDOI Listing

Comparing the cup deformation following implantation of a novel ceramic-on-ceramic hip resurfacing bearing to a metal standard in a cadaveric model.

Proc Inst Mech Eng H 2019 Apr 24:954411919845721. Epub 2019 Apr 24.

1 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Hip resurfacing is an attractive alternative to total hip replacement preserving bone and reducing dislocation risk. Recent metal-on-metal designs have caused failure due to metal wear debris. Ceramic implants may mitigate this risk. Read More

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http://dx.doi.org/10.1177/0954411919845721DOI Listing

Marker-based versus model-based radiostereometric analysis of total knee arthroplasty migration: a reanalysis with comparable mean outcomes despite distinct types of measurement error.

Acta Orthop 2019 Apr 24:1-9. Epub 2019 Apr 24.

a Department of Orthopaedics , Leiden University Medical Center , Leiden , the Netherlands.

Background and purpose - Pooling data of studies evaluating total knee arthroplasty migration using radiostereometric analysis (RSA) may be compromised when the RSA method used would influence estimated differences between groups. We therefore reanalyzed a marker-based RSA study with model-based RSA to assess possible limitations of each RSA method, including insert micromotions in modular TKA and their effect on estimated group differences. Patients and methods - All patients had received a cemented Triathlon implant (Stryker, Mahwah, NJ, USA) with either an all-polyethylene (n = 29) or a metal-backed (n = 28) tibial component. Read More

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http://dx.doi.org/10.1080/17453674.2019.1605692DOI Listing

Content validity and readability of patient-reported questionnaire instruments of hearing disability.

Int J Audiol 2019 Apr 24:1-11. Epub 2019 Apr 24.

g NIHR Biomedical Research Centre , University of Nottingham , Nottingham , UK.

Objective: This study evaluates the content validity (i.e. domains assessed) and readability levels of patient-reported questionnaire instruments using internationally recognised procedures and tools. Read More

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https://www.tandfonline.com/doi/full/10.1080/14992027.2019.1
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http://dx.doi.org/10.1080/14992027.2019.1602738DOI Listing
April 2019
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Association between Outdoor Air Pollution and Childhood Leukemia: A Systematic Review and Dose-Response Meta-Analysis.

Environ Health Perspect 2019 Apr;127(4):46002

1 Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , Modena, Italy.

Background: A causal link between outdoor air pollution and childhood leukemia has been proposed, but some older studies suffer from methodological drawbacks. To the best of our knowledge, no systematic reviews have summarized the most recently published evidence and no analyses have examined the dose-response relation.

Objective: We investigated the extent to which outdoor air pollution, especially as resulting from traffic-related contaminants, affects the risk of childhood leukemia. Read More

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http://dx.doi.org/10.1289/EHP4381DOI Listing

Effective delivery of mitomycin-C and meloxicam by double-layer electrospun membranes for the prevention of epidural adhesions.

J Biomed Mater Res B Appl Biomater 2019 Apr 24. Epub 2019 Apr 24.

Beijing Laboratory of Biomedical Materials, State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China.

Epidural adhesion between the spinal dura and the surrounding fibrous tissue often occurs post-laminectomy, resulting in clinical symptoms such as nerve compression and severe pain. In this study, we report a drug-loaded double-layered electrospun nanofiber membrane to prevent the occurrence of epidural adhesion. The nanofibers in both layers are made of a mixture of polycaprolactone (PCL) and chitosan (CS) but at different weight ratios. Read More

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http://dx.doi.org/10.1002/jbm.b.34394DOI Listing

Clinical importance of the updated Oxford classification in allograft IgA nephropathy.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea.

With the recent update to the Oxford classification for allograft IgA nephropathy (IgAN), additional investigations on the clinical significance of the updated components are warranted. We performed a retrospective cohort study at two tertiary hospitals. Kidney transplant recipients diagnosed with allograft IgAN were included in the study after additional review by specialized pathologists. Read More

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http://dx.doi.org/10.1111/ajt.15400DOI Listing

Strengthening nursing surveillance in general wards: a practice development approach.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

Conjoint Associate Professor, Metro North Hospital and Health Service, Herston QLD, Australia.

Aim: To explore the context and culture of nursing surveillance on an acute care ward.

Background: Prevention of patient deterioration is primarily a nursing responsibility in hospital. Registered nurses make judgements and act on emerging threats to patient safety through a process of nursing surveillance. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocn.14890
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http://dx.doi.org/10.1111/jocn.14890DOI Listing
April 2019
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Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus.

Int J Mol Med 2019 Jun 16;43(6):2420-2428. Epub 2019 Apr 16.

Biomedical Center and Institute of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, SK‑03601 Martin, Slovak Republic.

Mitochondria are crucial for neuronal cell survival and death through their functions in ATP production and the intrinsic pathway of apoptosis. Mitochondrial dysfunction is considered to play a central role in several serious human diseases, including neurodegenerative diseases, such as Parkinson's and Alzheimer's disease and ischemic neurodegeneration. The aim of the present study was to investigate the impact of transient global brain ischemia on the expression of selected proteins involved in mitochondrial dynamics and mitochondria‑associated membranes. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4168DOI Listing
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