1,175 results match your criteria Biomedical reports[Journal]


Deep learning opens new horizons in personalized medicine.

Biomed Rep 2019 Apr 13;10(4):215-217. Epub 2019 Mar 13.

Computational Biomedicine Laboratory (CBML), Institute of Computer Science (ICS), Foundation for Research and Technology Hellas (FORTH), 70013 Heraklion, Greece.

Although the idea of the personalization of patient care dates back to the time of Hippocrates, recent advances in diagnostic medical imaging and molecular medicine are gradually transforming healthcare services, by offering information and diagnostic tools enabling individualized patient management. Facilitating personalized / precision medicine requires taking into account multiple heterogenous parameters, such as sociodemographics, gene variability, environmental and lifestyle factors. Therefore, one of the most critical challenges in personalized medicine is the need to transform large, multi-modal data into decision support tools, capable of bridging the translational gap to the clinical setting. Read More

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http://www.spandidos-publications.com/10.3892/br.2019.1199
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http://dx.doi.org/10.3892/br.2019.1199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439426PMC
April 2019
1 Read

Association between genetic variants in CD1A and CD1D genes and pulmonary tuberculosis in an Iranian population.

Biomed Rep 2019 Apr 15;10(4):259-265. Epub 2019 Mar 15.

Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan 98167-4318, Iran.

Cluster of differentiation (CD)1 molecules are a highly conserved family of MCH-like transmembrane glycoproteins that bind lipid and glycolipid antigens and present a diverse range of microbial and self-glycolipids to antigen-specific T cells. The current study aimed to find out the impact of CD1A and CD1D polymorphisms on pulmonary tuberculosis (PTB). This case-control study encompassed 172 PTB patients and 180 healthy subjects. Read More

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http://dx.doi.org/10.3892/br.2019.1201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439427PMC
April 2019
1 Read

Urinary miRNA-29a-3p levels are associated with metabolic parameters via regulation of IGF1 in patients with metabolic syndrome.

Biomed Rep 2019 Apr 21;10(4):250-258. Epub 2019 Feb 21.

Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.

Circulating microRNAs (miRNAs or miRs) have been demonstrated to serve as diagnostic and prognostic biomarkers in metabolic syndrome (MetS). The role of urinary miRNAs in MetS diagnosis remains unknown. Here, elevated miR-29a-3p levels were observed in urine samples of patients with MetS compared with control subjects using a microarray analysis (n=4/group) and validation via reverse transcription-quantitative polymerase chain reaction (n=40/group). Read More

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http://dx.doi.org/10.3892/br.2019.1195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439429PMC
April 2019
1 Read

Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets.

Biomed Rep 2019 Apr 8;10(4):245-249. Epub 2019 Mar 8.

Department of Biology, School of Science and Technology, Nazarbayev University, Astana 010000, Republic of Kazakhstan.

The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of immune cells to provoke the proteolytic processing of cytokines and chemokines in order to stimulate lymphocytes. The present study analyzed peripheral blood mononuclear cells to characterize T cell populations in terms of their CatG content by flow cytometry. Read More

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http://dx.doi.org/10.3892/br.2019.1198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439432PMC

Effect of aging on the tendon structure and tendon-associated gene expression in mouse foot flexor tendon.

Biomed Rep 2019 Apr 13;10(4):238-244. Epub 2019 Mar 13.

Department of Medicine for Motor Organs, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

To evaluate the biological changes in tendons during the aging process, the present study examined the effect of aging on the tendon structure, distribution of collagen types I and III, and expression of tendon-associated genes, using flexor tendons in a mouse model. Histological assessment of the tendon structure and distribution of collagen types I and III were performed, and the expression of tendon-associated genes was evaluated in flexor digitorium longus tendons of young (8 weeks) and aged (78 weeks) female C57BL/6 mice. The results indicated that the Soslowsky score, based on the analysis of cellularity, fibroblastic changes, and collagen fiber orientation and disruption, was significantly increased, or worsened, in the tendons of the aged group compared with those in the young group. Read More

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http://dx.doi.org/10.3892/br.2019.1200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439433PMC
April 2019
1 Read

Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing fertilization.

Biomed Rep 2019 Apr 15;10(4):231-237. Epub 2019 Feb 15.

Department of Microbiology, 'Aretaieion' General Hospital, National and Kapodistrian University of Athens, Athens 11528, Greece.

Assisted reproductive techniques including fertilization (IVF) are being used increasingly worldwide and screening for genital tract infections (GTIs) is recommended prior to treatment as their presence may affect the success rate of IVF. The current study aimed to assess the possible associations between GTI-associated factors and reproductive outcome in a group of reproductive age fertile females and infertile females receiving IVF. A total of 111 infertile women enrolled in an IVF programme (Group A) and 104 fertile women (mothers of at least one child; Group B) underwent microbiological screening of vaginal and cervical samples. Read More

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http://dx.doi.org/10.3892/br.2019.1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439431PMC
April 2019
1 Read

Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling.

Biomed Rep 2019 Apr 5;10(4):218-224. Epub 2019 Mar 5.

Department of Neurology, University Hospital Zurich, CH-8091 Zurich, Switzerland.

Constitutive activation of Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most common oncogenic event in certain types of human cancer and is associated with poor patient survival. Small molecule signaling inhibitors have improved the clinical outcomes of patients with various cancer types but attempts to target KRAS have been unsuccessful. Plinabulin represents a novel class of agents that inhibit tubulin polymerization with a favorable safety profile in clinical trials. Read More

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http://dx.doi.org/10.3892/br.2019.1196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439430PMC

Blood concentrations and renal clearance of water-soluble vitamins in outpatients with ulcerative colitis.

Biomed Rep 2019 Mar 5;10(3):202-210. Epub 2019 Feb 5.

Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture, Hikone, Shiga 522-8533, Japan.

Few studies have investigated the association between dietary intake and blood concentrations of water-soluble vitamins in patients with ulcerative colitis (UC). In the present study, vitamin concentrations were measured in the blood and urinary excretion of 23 outpatients with UC and compared against a control group of 20 healthy participants. A weighed food record procedure was used to ensure controlled macronutrient and vitamin intakes of the UC cohort. Read More

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http://dx.doi.org/10.3892/br.2019.1191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403479PMC
March 2019
1 Read

Neutrophil extracellular trap components increase the expression of coagulation factors.

Biomed Rep 2019 Mar 23;10(3):195-201. Epub 2019 Jan 23.

Department of Hematology and Medical Oncology, Morales Meseguer University Hospital, Centro Regional de Hemodonación, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), 30003 Murcia, Spain.

Neutrophil extracellular traps (NETs) represent an important link between inflammation and thrombosis. Here, the present study aimed to investigate the influence of the NET components, DNA and histone H4, on hemostatic gene expression. A further aim was to confirm the influence of H4 on the expression of tissue factor (TF) and investigate a potential effect of DNA, and to test the involvement of miR-17/92 and its paralog miR-106b-25 in this regulation. Read More

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http://www.spandidos-publications.com/10.3892/br.2019.1187
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http://dx.doi.org/10.3892/br.2019.1187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403473PMC
March 2019
5 Reads

Role of Ala16Val polymorphism in primary brain tumors.

Biomed Rep 2019 Mar 7;10(3):189-194. Epub 2019 Feb 7.

Clinic of Neurosurgery, Medicana Sivas Hospital, 58050 Sivas, Turkey.

The present study aimed to investigate the possible association between the genetic polymorphism of the enzyme superoxide dismutase 2 (SOD2, also known as manganese-dependent SOD), Ala16Val (rs4880), and primary brain tumor risk in the Turkish population. Frequency of the gene rs4880 polymorphism was identified in 225 Turkish individuals (120 controls and 105 patients with primary brain tumor) by polymerase chain reaction-restriction fragment length polymorphism. Subject demographics and clinical characteristics were also recorded. Read More

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http://dx.doi.org/10.3892/br.2019.1192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403480PMC
March 2019
1 Read

Anti- antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes.

Biomed Rep 2019 Mar 17;10(3):183-188. Epub 2019 Jan 17.

Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan 8179498861, Iran.

is prevalent intracellular parasite and a cause of worldwide infection in the human population. An inhibitory effect of this parasite on cancer growth has been demonstrated in cell culture and animal models. To determine whether the anticancer activities of are associated with host immune response, in the current study the reactivity of anti- antiserum with the surface of cancer cell lines was investigated. Read More

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http://www.spandidos-publications.com/10.3892/br.2019.1186
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http://dx.doi.org/10.3892/br.2019.1186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403471PMC
March 2019
3 Reads

Inhibition of enterohemorrhagic O157:H7 infection in a gnotobiotic mouse model with pre-colonization by strains.

Biomed Rep 2019 Mar 7;10(3):175-182. Epub 2019 Feb 7.

Department of Animal Microbiology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8577, Japan.

Enterohemorrhagic (EHEC) O157:H7 has been known to cause outbreaks of hemorrhagic colitis and hemolytic uremic syndrome. We previously demonstrated that intestinal flora contribute to the prevention of EHEC infection in a mouse model. However, it has not yet been determined whether , a predominant genus in the human intestine, contributes to the prevention of EHEC infection. Read More

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http://dx.doi.org/10.3892/br.2019.1193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403472PMC
March 2019
1 Read

Identification of diagnostic upper gastrointestinal cancer tissue type-specific urinary biomarkers.

Biomed Rep 2019 Mar 5;10(3):165-174. Epub 2019 Feb 5.

School of Clinical Sciences and Community Health, University of Edinburgh, Edinburgh EH16 4SB, UK.

Several potential urinary biomarkers exhibiting an association with upper gastrointestinal tumour growth have been previously identified, of which S100A6, S100A9, rabenosyn-5 and programmed cell death 6-interacting protein (PDCD6IP) were further validated and found to be upregulated in malignant tumours. The cancer cohort from our previous study was subclassified to assess whether distinct molecular markers can be identified for each individual cancer type using a similar approach. Urine samples from patients with cancers of the stomach, oesophagus, oesophagogastric junction or pancreas were analysed by surface-enhanced laser desorption/ionization-time-of-flight mass spectrometry using both CM10 and IMAC30 (Cu-complexed) chip types and LC-MS/MS-based mass spectrometry after chromatographic enrichment. Read More

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http://dx.doi.org/10.3892/br.2019.1190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423495PMC
March 2019
1 Read

Changes in serum LDL, PCSK9 and microRNA-122 in patients with chronic HCV infection receiving Daclatasvir/Asunaprevir.

Biomed Rep 2019 Mar 4;10(3):156-164. Epub 2019 Feb 4.

Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.

The present study evaluated the changes in lipid profile, and the associations between serum protein convertase subtilisin/kexin 9 (PCSK9), microRNA (miR)122 and low-density lipoprotein variation following treatment of hepatitis C virus (HCV) genotype 1b infection with Daclatasvir/Asunaprevir. A total of 39 patients with HCV genotype 1b infection with chronic hepatitis received a 24-week treatment regimen of Daclatasvir/Asunaprevir. Laboratory data were obtained for each subject every 4 weeks during treatment and every 12 weeks after treatment. Read More

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http://dx.doi.org/10.3892/br.2019.1189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403470PMC
March 2019
2 Reads

Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma.

Biomed Rep 2019 Mar 25;10(3):147-155. Epub 2019 Jan 25.

Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post-transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. Read More

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http://dx.doi.org/10.3892/br.2019.1188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403481PMC
March 2019
1 Read

Circular RNAs in leukemia.

Biomed Rep 2019 Feb 10;0(0):1-5. Epub 2018 Dec 10.

Department of Medical Biology, Faculty of Medicine, Ege University, 35040 Bornova, Izmir, Turkey.

Circular RNAs (circRNAs) have been demonstrated to be biomarkers in human cancers. CircRNAs are majorly recognized in the transcript formation of eukaryotic genes. Research has also revealed that circRNAs regulate gene expression at the transcriptional, post-transcriptional, and translational levels. Read More

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http://dx.doi.org/10.3892/br.2018.1178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391710PMC
February 2019
1 Read

Alteration in cardiac PI3K/Akt/mTOR and ERK signaling pathways with the use of growth hormone and swimming, and the roles of miR21 and miR133.

Biomed Rep 2019 Feb 13;0(0):1-10. Epub 2018 Dec 13.

Department of Physiology, Trakya University Faculty of Medicine, Edirne 22030, Turkey.

Athletes misuse recombinant human growth hormone (r-hGH) to enhance their performance. Although r-hGH is known to increase cardiac hypertrophy, the underlying molecular mechanism remains unclear. The aim of the present study was to investigate the role of r-hGH in cardiac intracellular signaling pathways and of miR-21 and miR-133 expression in rat hearts during exercise. Read More

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http://dx.doi.org/10.3892/br.2018.1179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391709PMC
February 2019
2 Reads

Influence of nasal polyp tissue on the differentiation and activation of T lymphocytes in a co-culture system.

Biomed Rep 2019 Feb 8;10(2):119-126. Epub 2019 Jan 8.

Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Würzburg, D-97080 Würzburg, Germany.

T cell subpopulations in nasal polyps differ from peripheral lymphocytes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, little is known about the modulatory influence of the inflamed nasal polyp epithelial cells on the phenotype of the T cells. The aim of the present study was to assess this interaction. Read More

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http://dx.doi.org/10.3892/br.2019.1185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350210PMC
February 2019
1 Read

Influence of GnRH antagonist in reproductive women on in vitro fertilization and embryo transfer in fresh cycles.

Biomed Rep 2019 Feb 29;10(2):113-118. Epub 2018 Nov 29.

Department of Reproductive Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.

The aim of the present study was to evaluate the influence of a gonadotropin-releasing hormone (GnRH) antagonist compared with a GnRH agonist on fertilization (IVF) cycle outcome in reproductive women. The characteristics of treatment and outcomes of pregnancy were retrospectively compared between the antagonist (GnRH-A, antagonist group) and agonist (GnRH-a, agonist group) regimens. The area under the curve (AUC) of receiver operating characteristic (ROC) curves was also used to evaluate whether the endometrial thickness (cm), progesterone (P) level (ng/ml) and estradiol (E) level (pg/ml) on the day of human chorionic gonadotropin (hCG) administration (hCG day) had the ideal sensitivity and specificity for predicting clinical pregnancy. Read More

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http://dx.doi.org/10.3892/br.2018.1176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350209PMC
February 2019
4 Reads

Detection of G338R FGFR2 mutation in a Vietnamese patient with Crouzon syndrome.

Biomed Rep 2019 Feb 3;10(2):107-112. Epub 2019 Jan 3.

National Key Laboratory of Gene Technology, Institute of Biotechnology, Cau Giay, Ha Noi 10000, Vietnam.

Crouzon syndrome is a rare autosomal dominant genetic disorder, which causes the premature fusion of the cranial suture. Fibroblast growth factor receptor 2 (FGFR2) mutations are well-known causatives of Crouzon syndrome. The current study aimed to assess the gene associated with Crouzon syndrome in a Vietnamese family of three generations and to characterize their associated clinical features. Read More

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http://dx.doi.org/10.3892/br.2019.1181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350211PMC
February 2019
16 Reads

Circulating angiopoietin-like protein 2 levels are associated with decreased renal function in HIV subjects on cART: A potential marker of kidney disease.

Biomed Rep 2019 Feb 7;10(2):140-144. Epub 2019 Jan 7.

Department of Human Pathology in Adult and Developmental Age 'G. Barresi', University of Messina, I-98124 Messina, Italy.

Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-infected individuals, even in the antiretroviral therapy (ART) era. Inflammatory cytokines and adipokines have been suggested to play a role in the development of CKD. The aim of the present study was to examine the circulating levels of a novel proinflammatory cytokine, angiopoietin-like protein 2 (ANGPTL2), in a cohort of 72 HIV-positive subjects on ART. Read More

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http://dx.doi.org/10.3892/br.2019.1183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341407PMC
February 2019
1 Read

Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture.

Biomed Rep 2019 Feb 31;10(2):133-139. Epub 2018 Dec 31.

Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics.

Anterior cruciate ligament (ACL) rupture is one the most common musculoskeletal soft tissue injuries of the knee. Although the exact mechanisms of this injury remain uncertain, genetic variants have been considered to be an intrinsic risk factor associated with ACL rupture. Therefore, the aim of the present study was to determine whether the adiponectin +276G/T polymorphism is associated with susceptibility to ACL rupture in a Thai population. Read More

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http://dx.doi.org/10.3892/br.2018.1180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341408PMC
February 2019
2 Reads

Analysis of the rs2476601 polymorphism of PTPN22 in Mexican mestizo patients with leprosy.

Biomed Rep 2019 Feb 7;10(2):127-132. Epub 2019 Jan 7.

Laboratory of Immunology, Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa 80010, México.

Leprosy, a human chronic granulomatous disease caused by , remains endemic in certain countries despite the use of multidrug therapy. Recently, several host genes modulating the immune responses to infection have been suggested to influence the acquisition and clinical course of leprosy. Lymphoid protein tyrosine phosphatase, encoded by the protein tyrosine phosphatase non-receptor type 22 () gene, serves a negative regulatory role in T cell activation. Read More

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http://dx.doi.org/10.3892/br.2019.1184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341406PMC
February 2019
4 Reads

Clinicopathological features of cystic lesions in the eyelid.

Biomed Rep 2019 Feb 7;10(2):92-96. Epub 2018 Dec 7.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.

The aim of the present study was to investigate the clinicopathological features of cystic lesions in the eyelid. Clinicopathological profiles were retrospectively searched based on medical records of 35 patients with cystic lesions of the eyelids, which were surgically resected from January 2003 to June 2016. The cohort consisted of 16 men and 19 women. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1177
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http://dx.doi.org/10.3892/br.2018.1177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341405PMC
February 2019
10 Reads

Current status of uterine regenerative medicine for absolute uterine factor infertility.

Biomed Rep 2019 Feb 4;10(2):79-86. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Though assisted reproduction technology has been developed, a treatment for absolute uterine factor infertility (AUFI), such as defects in the uterus, has not yet been established. Regenerative medicine has been developed and applied clinically over recent years; however, whole solid organs still cannot be produced. Though uterine regeneration has the potential to be a treatment for AUFI, there have been only a few studies on uterine regeneration involving the myometrium . Read More

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http://dx.doi.org/10.3892/br.2019.1182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341411PMC
February 2019
1 Read

Detection of oral bacteria on the tongue dorsum using PCR amplification of 16S ribosomal RNA and its association with systemic disease in middle-aged and elderly patients.

Biomed Rep 2019 Jan 26;10(1):70-76. Epub 2018 Nov 26.

Department of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

The association between oral health and systemic disease is recognized in the literature. The present study aimed to clarify the association between oral bacteria on the tongue dorsum and factors associated with oral health and systemic disease in middle-aged and elderly patients. The association between bacterial numbers, oral health status and systemic disease was preliminarily investigated in 70 patients (mean age, 69. Read More

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http://dx.doi.org/10.3892/br.2018.1175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299208PMC
January 2019
1 Read

Phototherapy is associated with the decrease in serum globulin levels in neonatal hyperbilirubinemia.

Biomed Rep 2019 Jan 9;10(1):63-69. Epub 2018 Nov 9.

Department of Pediatrics and Neonatology, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.

Previous studies have indicated that phototherapy may be associated with childhood immune disorders in later life. The present study aimed to assess the effects of phototherapy as a risk factor in the decrease in serum globulin (GLB) levels during neonatal hyperbilirubinemia. A total of 430 full-term infants aged between 1 and 28 days, diagnosed with neonatal hyperbilirubinemia, were enrolled in the present study. Read More

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http://dx.doi.org/10.3892/br.2018.1166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299213PMC
January 2019

Systematic review and meta-analysis of the protective effect of resveratrol on multiple organ injury induced by sepsis in animal models.

Biomed Rep 2019 Jan 14;10(1):55-62. Epub 2018 Nov 14.

Intensive Care Unit, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.

Sepsis may directly lead to multiple organ failure, which is among the leading causes of mortality in critically ill patients. According to data released by the Global Sepsis Alliance, the number of mortalities due to sepsis exceeded the combined number for prostate cancer, breast cancer and AIDS in 2012. To date, studies have reported that resveratrol has marked positive effects including anti-inflammatory, anti-oxidative and pro-microcirculatory functions in sepsis-induced organ injury, significantly improving the survival time and mortality of sepsis animals. Read More

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http://dx.doi.org/10.3892/br.2018.1169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299207PMC
January 2019
3 Reads

Antioxidant and neuroprotective effects of lycopene and insulin in the hippocampus of streptozotocin-induced diabetic rats.

Biomed Rep 2019 Jan 20;10(1):47-54. Epub 2018 Nov 20.

Department of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan 45139-56111, Iran.

In the present study the antioxidant and neuroprotective effects of insulin and lycopene on passive avoidance memory, total antioxidant capacity (TAC), malondialdehyde activity (MDA) and prevention of apoptosis in the hippocampus streptozotocin-induced diabetic rats were examined. The rats were randomly divided to six experimental groups (n=8 per group): Non-diabetic (controls); diabetic; diabetic treated with lycopene; diabetic treated with insulin; diabetic treated with lycopene and insulin; and normal treated with lycopene. Intraperitoneal injection of single dose (60 mg/kg) streptozotocin (STZ) was used to induce the diabetes rat model. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1171
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http://dx.doi.org/10.3892/br.2018.1171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299209PMC
January 2019
8 Reads

Digit ratio, personality and emotions in skydivers.

Biomed Rep 2019 Jan 26;10(1):39-46. Epub 2018 Nov 26.

Department of Biomedical and Biotechnological Sciences, University of Catania, I-95123 Catania, Italy.

The aim of the present study was investigate if there is an association between second-to-fourth digit length (2D:4D) ratio and personality factors capable of serving as predictors of individual choice towards high-risk activities in a group of experts skydivers; Furthermore, their skills in regulating anxiety and emotions were assessed. The 2D:4D ratio of the right hand of 41 expert skydivers was measured and each of them completed four questionnaires: Big Five Questionnaire-2 (BFQ-2), Profile of Mood States (POMS), State-Trait Anxiety Inventory Form Y (STAI-Y) and Risk-Taking Inventory. Lower 2D:4D ratios did not appear associated with a greater propensity for taking risks but rather with a lower aptitude to assume precautions in unsafe conditions. Read More

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http://dx.doi.org/10.3892/br.2018.1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299204PMC
January 2019
1 Read

Docking study of flavonoid derivatives as potent inhibitors of influenza H1N1 virus neuraminidase.

Biomed Rep 2019 Jan 23;10(1):33-38. Epub 2018 Nov 23.

Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran 14359-16471, Iran.

Influenza type A is considered as a severe public health concern. The mechanism of drugs applied for the control of this virus depends on two surface glycoproteins with antigenic properties, namely hemagglutinin (HA) and neuraminidase (NA). HA aids the virus to penetrate cells in the early stage of infection and NA is an enzyme with the ability to break glycoside bonds, which enables virion spread through the host cell membrane. Read More

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http://dx.doi.org/10.3892/br.2018.1173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299203PMC
January 2019

Analysis of (rs121912765) polymorphism in Iranian women with history of recurrent spontaneous abortion: A case-control study.

Biomed Rep 2019 Jan 15;10(1):29-32. Epub 2018 Nov 15.

Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd 2362542566, Iran.

Recurrent spontaneous abortion (RSA) defines as the consecutive loss of at least two pregnancies prior to the 20th week of gestation. A qualitative diagnosis of infertility can only be performed by focusing on female and male physical abnormalities, endocrine irregularities and genetic conditions. The aim of the present study was to evaluate the association between a common polymorphism of bone morphogenetic protein 4 () (rs121912765; 278A>G) with female infertility. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1170
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http://dx.doi.org/10.3892/br.2018.1170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299254PMC
January 2019
5 Reads

Mitochondrial DNA variations in tongue squamous cell carcinoma.

Biomed Rep 2019 Jan 9;10(1):23-28. Epub 2018 Nov 9.

Key Laboratory of Genetics and Birth Health of Hunan Province, Family Planning Institute of Hunan Province, Changsha, Hunan 410126, P.R. China.

Tongue squamous cell carcinoma (TSCC) is the most common type of oral carcinoma. Mitochondrial DNA (mtDNA) is a circular DNA molecule of 16,569 bp, which functionally encompasses a regulatory non-coding region (D-loop) and 37 encoding genes that correspond to 13 subunits of respiratory chain complexes (I, III, IV and V), 22 transfer RNAs and 2 ribosomal (r)RNAs. Recently, mtDNA has been implicated as a mutation hotspot in various tumors. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1167
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http://dx.doi.org/10.3892/br.2018.1167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299206PMC
January 2019
11 Reads

Osteogenic effects of via up-regulation of Runx2 in osteoporosis.

Biomed Rep 2019 Jan 20;10(1):17-22. Epub 2018 Nov 20.

Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.

Turcz (labiatae) has been suggested to promote bone growth. However, the anti-osteoporotic effects of have not yet been elucidated. In the present study, the osteogenic effects of were investigated in an osteoporosis model. Read More

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http://dx.doi.org/10.3892/br.2018.1172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299205PMC
January 2019
2 Reads

Overall survival of classical Hodgkins lymphoma in Saudi patients is affected by XPG repair gene polymorphism.

Biomed Rep 2019 Jan 30;10(1):10-16. Epub 2018 Oct 30.

Department of Higher Studies, Arabian Gulf University, Manama 26671, Kingdom of Bahrain.

In Hodgkin's lymphoma (HL), single nucleotide polymorphisms (SNPs) of specific DNA repair genes have been identified to have an important role in the risk of HL. Consequently, they may also serve an important role in HL prognosis and disease outcome. The present study aimed to define an SNP molecular profile, based on DNA repair genes mutations, as predictive biomarkers for the prognostic outcome of patients with Classical HL (CHL) in Saudi Arabia. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1165
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http://dx.doi.org/10.3892/br.2018.1165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299211PMC
January 2019
12 Reads

A comprehensive review of available omics data resources and molecular profiling for precision glioma studies.

Biomed Rep 2019 Jan 14;10(1):3-9. Epub 2018 Nov 14.

Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China.

Gliomas are the most common and lethal type of primary malignant central nervous system tumors, with an extremely poor prognosis. The latest progression in the technological development of sequencing/microarray and bioinformatics has provided insights into the glioma genome. These technologies have generated large amounts of easily accessible biological omics data, providing an unprecedented opportunity to study glioma formation. Read More

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http://dx.doi.org/10.3892/br.2018.1168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299212PMC
January 2019

Atrial fibrillation following treatment with paclitaxel: A case report.

Biomed Rep 2018 Dec 12;9(6):540-544. Epub 2018 Oct 12.

Department of Clinical Pharmacy, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, Sichuan 621000, P.R. China.

Paclitaxel (PTX) is an antimicrotubule agent, and is effective in treating a wide range of solid tumors. However, its use may lead to cardiovascular toxicities, the manifestations of which include arrhythmia, heart failure, acute myocardial ischemia and atrial fibrillation (AF). AF is among the severe reactions to the PTX cardiotoxicity, and a cause for substantial morbidity and mortality. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1158
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http://dx.doi.org/10.3892/br.2018.1158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256260PMC
December 2018
18 Reads

Distinct HLA class I and II genotypes and haplotypes are associated with multiple sclerosis in Bahrain.

Biomed Rep 2018 Dec 24;9(6):531-539. Epub 2018 Oct 24.

Department of Molecular Medicine, Princess Al-Jawhara Center for Genetics and Inherited Diseases, Arabian Gulf University, Manama 329, Bahrain.

Multiple sclerosis (MS) has become prevalent in the Arabian Gulf area with high incidence in Bahrain due to environmental influences and genetic susceptibilities, but there is a lack of study into human leukocyte antigen (HLA) types in patients with MS in Bahrain. The present study aimed to study the HLA types expressed in MS patients compared with in control subjects. Blood samples from 50 Bahraini patients with MS and 50 Bahraini control subjects' were subjected to HLA tissue typing by polymerase chain reaction using sequence-specific primers. Read More

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http://dx.doi.org/10.3892/br.2018.1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256251PMC
December 2018

Association between serum 25-hydroxyvitamin D, hemoglobin A1c and fasting blood glucose levels in adults with diabetes mellitus.

Biomed Rep 2018 Dec 17;9(6):523-530. Epub 2018 Oct 17.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.

In the present study, the aim was to investigate the association between serum 25-hydroxyvitamin D concentration and measures of glycemic control including hemoglobin A1c (HbA1c) and fasting blood glucose (FBG) in adult patients with diabetes mellitus (DM) from the north of Jordan. Another aim was to compare serum levels of 25-hydroxyvitamin D between patients with good glycemic control and patients with uncontrolled DM. This was a cross-sectional study that included 261 participants with DM. Read More

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http://dx.doi.org/10.3892/br.2018.1159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256128PMC
December 2018

Predictive value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin III for acute coronary syndrome risk.

Biomed Rep 2018 Dec 19;9(6):517-522. Epub 2018 Oct 19.

Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.

The aim of the present study was to observe the role of lipoprotein-associated phospholipase A2 (Lp-PLA2) and antithrombin III (AT-III) in patients with acute coronary syndrome (ACS), and the combination of Global Registry of Acute Coronary Events (GRACE) score to determine the value of coronary heart disease risk stratification. A total of 309 patients admitted to the Affiliated Hospital of Xuzhou Medical University were enrolled. The patients were divided into two groups: The ACS (183 cases) and control (126 cases) groups. Read More

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http://dx.doi.org/10.3892/br.2018.1162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256189PMC
December 2018
1 Read

Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.

Biomed Rep 2018 Dec 18;9(6):511-516. Epub 2018 Oct 18.

Department of Physiology and Biochemistry, Princess Basma Teaching Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 21110, Jordan.

Previous studies have shown that progesterone could inhibit muscle contraction in various sites of the gastrointestinal tract. The underlying mechanisms responsible for these inhibitory effects of progesterone are not fully known. The aim of the current study was to investigate the effect of progesterone on the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway and muscle contraction in the stomach. Read More

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http://dx.doi.org/10.3892/br.2018.1161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256236PMC
December 2018
6 Reads

Energy handling in renal tubular epithelial cells of the hamster, a native hibernator, under warm anoxia or reoxygenation.

Biomed Rep 2018 Dec 12;9(6):503-510. Epub 2018 Oct 12.

Department of Nephrology, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece.

Ischemia-reperfusion (I-R) injury causes several diseases, including acute kidney injury. Hibernating mammals survive periods of torpor with a marked drop in tissue perfusion, interspersed with periods of arousal, and consequently I-R injury. In the present study, sensitivity to anoxia and/or reoxygenation and alterations in cellular ATP and homeostasis of the two most energy consuming processes, protein translation and Na-K-ATPase function, were evaluated in renal proximal tubular epithelial cells of mouse or native hibernator hamster origin. Read More

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http://dx.doi.org/10.3892/br.2018.1157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256125PMC
December 2018

Canagliflozin improves obesity and insulin resistance in a diabetic patient with Cushings disease undergoing postoperative steroid therapy: A case report.

Biomed Rep 2018 Dec 1;9(6):497-502. Epub 2018 Oct 1.

Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

A 47-year-old woman with diabetes treated with high-dose insulin was admitted to Mie University Hospital, Tsu, Japan, for screening of secondary diabetes mellitus and obesity. Laboratory tests and imaging studies were consistent with Cushing's disease (CD). The patient underwent trans-sphenoidal pituitary surgery. Read More

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http://dx.doi.org/10.3892/br.2018.1153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256191PMC
December 2018

Inhibition of osteoblast differentiation by ritonavir.

Biomed Rep 2018 Dec 2;9(6):491-496. Epub 2018 Oct 2.

Department of Internal Medicine, Teikyo University, Tokyo 173-8606, Japan.

Osteoporosis is one of the chronic complications seen in human immunodeficiency virus (HIV)-infected patients, and affects patients at high prevalence. The causes of osteoporosis in HIV-infected patients are multiple, and include chronic HIV infection, living habits such as smoking and alcohol consumption, and antiretroviral drug use. Among antiretroviral drugs, protease inhibitors have been reported to be associated with osteoporosis. Read More

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http://dx.doi.org/10.3892/br.2018.1154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256180PMC
December 2018

Association of vitamin D receptor ApaI gene polymorphism with osteoporosis susceptibility in postmenopausal Han Chinese women in Xinjiang.

Biomed Rep 2018 Dec 3;9(6):483-490. Epub 2018 Oct 3.

Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China.

Osteoporosis is a polygenic disorder and has been demonstrated to be associated with ~30 candidate genes, the majority of which have also been implicated in the regulation of bone mineral density (BMD). Vitamin D receptor (VDR) is the candidate gene that has been most extensively studied. Certain studies have reported that the VDR single nucleotide polymorphism ApaI is associated with the risk of osteoporosis in Caucasian and African women. Read More

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http://dx.doi.org/10.3892/br.2018.1155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256115PMC
December 2018
2 Reads

Pharmacokinetics of 10-gingerol and 6-shogaol in the plasma of healthy subjects treated with red ginger ( var. Rubrum) suspension.

Biomed Rep 2018 Dec 23;9(6):474-482. Epub 2018 Oct 23.

Clinical Pharmacy, Riau Islands General Hospital, Tanjung Pinang, Riau Islands 29125, Indonesia.

Red ginger ( var. Rubrum) is among the most widely consumed medicinal herbs in Indonesia. Ginger rhizome contains phenol compounds including gingerol and shogaol. Read More

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http://dx.doi.org/10.3892/br.2018.1163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256190PMC
December 2018

Epigenetic modulation during hippocampal development.

Biomed Rep 2018 Dec 18;9(6):463-473. Epub 2018 Oct 18.

Department of Pharmacology, Medical School of Yangtze University, Jingzhou, Hubei 434023, P.R. China.

The hippocampus is located in the limbic system and is vital in learning ability, memory formation and emotion regulation, and is associated with depression, epilepsy and mental retardation in an abnormal developmental situation. Several factors have been found to modulate the development of the hippocampus, and epigenetic modification have a crucial effect in this progress. The present review summarizes the epigenetic modifications, including DNA methylation, histone acetylation, and non-coding RNAs, regulating all stages of hippocampal development, focusing on the growth of Ammons horn and the dentate gyrus in humans and rodents. Read More

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http://dx.doi.org/10.3892/br.2018.1160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256110PMC
December 2018

D-dimer as a potential clinical marker for predicting metastasis and progression in cancer.

Biomed Rep 2018 Nov 14;9(5):453-457. Epub 2018 Sep 14.

Department of Clinical Laboratory, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China.

D-dimer is a widely used biomarker for indicating the activation of coagulation and fibrinolysis, and is reported to serve important roles in cancer progression. The aim of the current retrospective study was to investigate the association of D-dimer plasma level with the development of various cancers. Patients with breast (n=86), gastric (n=317), pancreatic (n=37), colon (n=153) and rectal (n=137) cancers and 92 healthy volunteers were assessed in the present study. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1151
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http://dx.doi.org/10.3892/br.2018.1151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201047PMC
November 2018
4 Reads

Serum homocysteine is associated with polycystic ovarian syndrome in Jordan.

Biomed Rep 2018 Nov 13;9(5):439-445. Epub 2018 Sep 13.

Department of Physiology and Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Polycystic ovarian syndrome (PCOS) is a prevalent endocrinopathy among women of a reproductive age. Although not included in the diagnostic criteria, insulin resistance (IR) is a major characteristic of PCOS and may contribute to its development. The exact cause of IR remains unknown but appears to be multifactorial. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1149
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http://dx.doi.org/10.3892/br.2018.1149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200971PMC
November 2018
20 Reads