1,282 results match your criteria Biomedical reports[Journal]


Association of single-nucleotide polymorphisms in antioxidant genes and their gene-gene interactions with risk of male infertility in a Chinese population.

Biomed Rep 2020 Jul 18;13(1):49-54. Epub 2020 May 18.

Research Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

The antioxidant defense system protects DNA from the damaging effects of oxidative stress and is hypothesized to be associated with an increased risk of male infertility. Polymorphisms in antioxidant genes and the gene-gene interactions associated with the antioxidant system may increase the potential risk of male infertility. In the present case-controlled study, the individual link between seven gene polymorphisms ( rs1800566, rs4880, rs1571858, rs3814309, rs7483, rs11807 and rs1695) and the risk of male infertility was investigated. Read More

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http://dx.doi.org/10.3892/br.2020.1306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257938PMC

Identification of prognostic gene biomarkers for metastatic skin cancer using data mining.

Biomed Rep 2020 Jul 18;13(1):22-30. Epub 2020 May 18.

School of Management, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Skin cancer is a common malignant tumor in China and throughout the world, and the rate of recurrence is considerably high, thus endangering the quality of life and health of patients, and increasing the economic burden and pressure to the families of those afflicted. Due to the limitations of traditional drug treatments, it is difficult to achieve the desired therapeutic effect of complete removal. However, targeted gene therapy may be a novel means of treating skin cancer, as the targeted nature of treatment may improve therapeutic outcomes. Read More

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http://dx.doi.org/10.3892/br.2020.1307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257933PMC

Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review).

Biomed Rep 2020 Jul 15;13(1):15-21. Epub 2020 May 15.

Department of Emergency Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.

Osteogenic differentiation originating from mesenchymal stem cells (MSCs) requires tight co-ordination of transcriptional factors, signaling pathways and biomechanical cues. Dysregulation of such reciprocal networks may influence the proliferation and apoptosis of MSCs and osteoblasts, thereby impairing bone metabolism and homeostasis. An increasing number of studies have shown that long non-coding (lnc)RNAs are involved in osteogenic differentiation and thus serve an important role in the initiation, development, and progression of bone diseases such as tumors, osteoarthritis and osteoporosis. Read More

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http://dx.doi.org/10.3892/br.2020.1305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257936PMC

Effect of cytokine treatment on the expression and secretion of brain derived neurotrophic factor in the smooth muscle of the rat colon.

Biomed Rep 2020 Jul 11;13(1):55-60. Epub 2020 May 11.

Department of Physiology and Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

The production of pro-inflammatory cytokines and chemokines is increased during inflammatory bowel disease (IBD). Previously, it was demonstrated that brain derived neurotrophic factor (BDNF) expression is increased in experimental models of colitis. BDNF is partially responsible for the structural and functional changes that take place during IBD. Read More

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http://dx.doi.org/10.3892/br.2020.1302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238405PMC

Tissue gene mutation profiles in patients with colorectal cancer and their clinical implications.

Biomed Rep 2020 Jul 12;13(1):43-48. Epub 2020 May 12.

R&D Department, Labway Clinical Laboratories, Shanghai 210000, P.R. China.

Colorectal cancer (CRC) is one of the most common types of cancer in the world, and targeted therapy is frequently used in the clinical management of the disease. A complete and accurate picture of tissue gene mutations is therefore critical. Tissue specimens from 117 patients with CRC were used for high throughput DNA next-generation sequencing (NGS) analysis. Read More

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http://dx.doi.org/10.3892/br.2020.1303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238404PMC

Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine.

Biomed Rep 2020 Jul 12;13(1):37-42. Epub 2020 May 12.

Department of Host Defense and Biochemical Research, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, Japan.

The aim of the present study was to evaluate the anti-inflammatory effects of citrulline (Cit), glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) on synovial cells, which are primarily involved in inflammatory joint diseases. The combined effect of Cit, GlcN and GlcNAc on synovial cell inflammation was assessed by measuring IL-1β-induced IL-6 production. GlcN and GlcNAc (0. Read More

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http://dx.doi.org/10.3892/br.2020.1304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238408PMC

Nutritional habits and free grazing regimen of productive animals along with specific ingredients are influential factors for the antioxidant properties of milk: From farm to market.

Biomed Rep 2020 Jul 28;13(1):31-36. Epub 2020 Apr 28.

Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.

Milk is a fundamental product of animal origin for human health and well-being. It possesses crucial biological properties, which depend on its composition and production methodology. To this end, one of the aims of the present study was to assess the impact of the nutritional and dwelling patterns of productive animals on the antioxidant potency of their generated milk. Read More

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http://dx.doi.org/10.3892/br.2020.1301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238402PMC

Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review).

Biomed Rep 2020 Jul 27;13(1):3-14. Epub 2020 Apr 27.

Laboratorio de Materiales Biotecnológicos, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes-Imbice-Conicet-Cicpba, Bernal, Buenos Aires B1876BXD, Argentina.

Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Read More

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http://dx.doi.org/10.3892/br.2020.1300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238406PMC

Anti-inflammatory effects of glycine thymosin β4 eye drops in experimental dry eye.

Biomed Rep 2020 Jun 2;12(6):319-325. Epub 2020 Apr 2.

Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju 61469, Republic of Korea.

The aim of the present study was to investigate the anti-inflammatory effects of glycine thymosin β4 (Gly-Tβ4) eye drops, and to compare the efficacy of topical Gly-Tβ4 with Cyclosporine A (CsA) in a mouse model of experimental dry eye (EDE). Eye drops consisting of balanced salt solution (BSS), 0.1% Gly-Tβ4 or 0. Read More

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http://dx.doi.org/10.3892/br.2020.1296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201140PMC

Effect of procalcitonin on the prognosis of patients with COPD.

Biomed Rep 2020 Jun 22;12(6):313-318. Epub 2020 Apr 22.

Geriatrics Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

The aim of the present study was to investigate the effect of procalcitonin levels on the prognosis of chronic obstructive pulmonary disease (COPD), and its relationship with other indices of infection. Inpatients diagnosed with acute aggravation of COPD between January 2017 and June 2018 were enrolled in the present study. Troponin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, percentage of neutrophils (NE%), hospitalization days and hospitalization expenses were collected and followed up for half a year to observe the survival rate in patients with COPD and the risk of acute aggravation. Read More

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http://dx.doi.org/10.3892/br.2020.1298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201139PMC

Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling.

Biomed Rep 2020 Jun 22;12(6):295-302. Epub 2020 Apr 22.

Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan.

Fatty liver disease (FLD) is characterized by accumulation of excess fat in the liver. The underlying molecular mechanism associated with the progression of the disease has been in elusive. Hepatocellular demise due to increased oxidative stress resulting in an inflammatory response may be a key feature in FLD. Read More

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http://dx.doi.org/10.3892/br.2020.1299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201141PMC

Evaluation of non-coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity.

Biomed Rep 2020 Jun 17;12(6):339-347. Epub 2020 Mar 17.

National Cancer Institute, Apeksha Hospital, Maharagama 10280, Sri Lanka.

Mitochondrial DNA (mtDNA) mutations have been reported to be associated with various diseases, including cancer. The present study investigated the mtDNA non-coding region mutations and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in Sri Lankan Sinhalese women. Mitochondrial macro-haplogroups were determined using PCR-restriction fragment length polymorphism, whereas non-coding region sequences were determined using Sanger sequencing. Read More

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http://dx.doi.org/10.3892/br.2020.1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184950PMC

Cyst of the Canal of Nuck in adult females: A case report and systematic review.

Biomed Rep 2020 Jun 27;12(6):333-338. Epub 2020 Mar 27.

Third Department of Surgery, Attiko University Hospital, National and Kapodistrian University of Athens, Athens 12462, Greece.

Defects in the Canal of Nuck are rare abnormalities of the female genitalia, which are typically detected and repaired in young age. In the present report, a case of a Nuck cyst in a 40-year old female patient is described. Additionally, the current literature concerning cases of women with hydrocele of Nuck canal was systematically reviewed. Read More

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http://dx.doi.org/10.3892/br.2020.1295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184959PMC

Cross-reactivity between and in immunotherapy extracts for the treatment of allergy to .

Biomed Rep 2020 Jun 6;12(6):326-332. Epub 2020 Apr 6.

Department of Allergology, Hospital of Sagunto, 46520 Valencia, Spain.

and are the two most common subspecies of the genus. and have exhibited cross-reactivity in previous studies. pollen is the main cause of allergy in the Mediterranean area. Read More

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http://dx.doi.org/10.3892/br.2020.1297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184951PMC

Novel mutation of the gene in two cases of paroxysmal kinesigenic dyskinesia: Two case reports.

Biomed Rep 2020 Jun 17;12(6):309-312. Epub 2020 Mar 17.

Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200025, P.R. China.

Paroxysmal kinesigenic dyskinesia (PKD) is a rare condition characterized by recurrent brief episodes of dystonia, chorea, athetosis or any combination of these, without alterations of consciousness. The () gene has been widely investigated as a causative gene of PKD. To date, a cluster of pathogenic variants associated with PKD have been identified in the gene. Read More

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http://dx.doi.org/10.3892/br.2020.1293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184952PMC

Immunostimulatory effects of cell wall-based nanoparticles in boiled radix water extracts involves TLR4.

Biomed Rep 2020 Jun 23;12(6):303-308. Epub 2020 Mar 23.

Division of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

A number of immunostimulant effects of herbal medicines have been reported; however, the underlying mechanisms of their immunostimulatory effects have not been elucidated in detail. Our previous study showed that sugar-based nanoparticles derived from cell walls acted as the immunostimulatory component of boiled radix water extracts. Therefore, the aim of the present study was to clarify the molecular mechanisms by which these cell wall-based nanoparticles functioned as immunostimulants. Read More

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http://dx.doi.org/10.3892/br.2020.1294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184953PMC

A novel familial mutation associated with Treacher Collins syndrome: A case report.

Biomed Rep 2020 May 28;12(5):285-289. Epub 2020 Feb 28.

Department for Special Needs, Aristotle University of Thessaloniki Achepa Hospital, 54636 Thessaloniki, Greece.

Treacher Collins syndrome (TCS) is a type of mandibulofacial dysostosis with incomplete penetrance and high intra- and interfamilial clinical heterogeneity, and it is associated with mutations of treacle ribosome biogenesis factor 1 (TCOF1), and RNA polymerase I and III subunit (POLR1)C and POLR1D genes. In the present case report, a patient with TCS with auricle dysplasia and hearing loss accompanied with intellectual disability is described. Sequence analysis was performed on blood samples from the patient and his father via oligonucleotide-based target capture, followed by next-generation sequencing. Read More

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http://dx.doi.org/10.3892/br.2020.1284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100132PMC

Relationship between miR-155 and miR-146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort.

Biomed Rep 2020 May 4;12(5):276-284. Epub 2020 Mar 4.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt.

Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. It was previously demonstrated that miR-155 and miR-146a served a vital role in the pathophysiology of MS, and single nucleotide polymorphisms in miR-155 and miR-146a were found to be associated with the susceptibility to different autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type I diabetes. The aim of the present study was to analyze the association between susceptibility to MS and two genetic polymorphisms (miR-155 rs767649 A>T and miR-146a rs57095329 A>G) in a cohort of Egyptian patients. Read More

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http://dx.doi.org/10.3892/br.2020.1286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100139PMC

Different continuous training modalities result in distinctive effects on muscle structure, plasticity and function.

Biomed Rep 2020 May 28;12(5):267-275. Epub 2020 Feb 28.

Department of Systems Medicine, University of Rome Tor Vergata, I-00133 Rome, Italy.

The effects of training on muscle structure are dependent on adaptive changes induced by different intensities of physical exercise. Evidence has shown that aerobic training is able to induce adaptive changes to muscle structure based on intensity. The aim of the present study was to investigate the effects of different methods of continuous aerobic training in mice using functional, morphological and biomolecular approaches. Read More

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http://dx.doi.org/10.3892/br.2020.1283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100130PMC

Examination of associations between personality traits, and polymorphisms of MAO-A and 5-HTT with the severity of menopausal symptoms and depression levels.

Biomed Rep 2020 May 4;12(5):259-266. Epub 2020 Mar 4.

Shahid Yahya Nezhad Hospital, Babol University of Medical Sciences, Babol, Mazandaran 47135-547, Iran.

The aim of the present study was to investigate the association between different personality traits with monoamine oxidase A (MAO-A) and serotonin transporter (5-HTT), and to examine their effects on the severity of menopause symptoms as well as the levels of depression in menopausal women. The study was designed as an analytical cross-sectional study, performed on 132 healthy post-menopausal women in Iran. Personality was assessed using the Revised Edition of the NEO Personality Index (Neuroticism-Extroversion-Openness-Five Factor Inventory). Read More

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http://dx.doi.org/10.3892/br.2020.1287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100127PMC

Nitric oxide metabolism is impaired by type 1 diabetes and diabetic nephropathy.

Biomed Rep 2020 May 4;12(5):251-258. Epub 2020 Mar 4.

Department of Medical Biochemistry, Faculty of Medicine, University of Latvia, LV-1004 Riga, Latvia.

Diabetes leads to reduced nitric oxide bioavailability, resulting in endothelial dysfunction. However, overproduction of nitric oxide due to hyperglycaemia is associated with oxidative stress and tissue damage. The objective of this study was to characterise nitric oxide production (NO) and added nitrite and nitrate (NO+NO) concentration in the blood and urine of patients with and without diabetic nephropathy. Read More

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http://dx.doi.org/10.3892/br.2020.1288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100134PMC

Reader-free ELISPOT assay for immuno-monitoring in peptide-based cancer vaccine immunotherapy.

Biomed Rep 2020 May 5;12(5):244-250. Epub 2020 Mar 5.

Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

Cancer vaccine immunotherapy is a therapy that induces cellular immune responses against a target molecule to elicit clinical anti-tumor effects. These cellular immune responses against the target molecule are monitored to evaluate whether the antigen-specific cellular immune responses are induced and maintained during the vaccination period. Enzyme-linked immunospot (ELISPOT) assay is widely performed to analyze not only the frequency of immune cells, but also their effector functions as determined by their cytokine production/secretion. Read More

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http://dx.doi.org/10.3892/br.2020.1289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100143PMC

Immunological markers and in patients with stomach cancer: Expression and correlation.

Biomed Rep 2020 May 4;12(5):233-243. Epub 2020 Mar 4.

Departamento de Microbiología, Universidad Autónoma de Aguascalientes, Aguascalientes Ags, CP 20131, México.

Programmed death-ligand 1 (PD-L1) and ICOS-L (also referred to as B7 homolog 1 and 2, respectively) modulate the immune inflammatory response. The aim of the present study was to examine the expression levels of these inflammatory mediators in two groups of patients with an () infection; patients with and without gastric cancer. The association between bacterial virulence factors, CagA and VacA, was also examined, as well as their correlation with the inflammatory profile. Read More

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http://dx.doi.org/10.3892/br.2020.1285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100142PMC

Alterations in glutathione, nitric oxide and 3-nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet-induced diabetes.

Biomed Rep 2020 May 11;12(5):222-232. Epub 2020 Mar 11.

Instituto Politécnico Nacional, Escuela Superior de Medicina, Mexico City 11340, Mexico.

Oxidative stress is involved in the development of diabetes. Nitric oxide (NO) contributes to oxidative stress, affects the synthesis of glutathione (GSH) in tissues and also regulates important physiological processes. The levels of nitrosative stress, assessed by measuring the levels of 3-nitrotirosina (3NT) as well as the bioavailability of NO are modulated by exercise and hyperbaric oxygenation (HBO). Read More

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http://dx.doi.org/10.3892/br.2020.1291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100140PMC

Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis.

Biomed Rep 2020 May 28;12(5):211-221. Epub 2020 Feb 28.

Department of Internal Medicine, Skane University Hospital, Lund University, 205 02 Malmo, Sweden.

The cytoplasmic protein AXIN1 is involved in the Wnt signalling pathway and its expression is increased in patients with endometriosis compared with healthy controls. The aim of the present cross-sectional study was to further assess the levels of AXIN1 and other inflammatory biomarkers in patients with endometriosis. Patients with laparoscopy-verified endometriosis were recruited (n=172) and completed a questionnaire regarding socioeconomic factors, lifestyle habits and medical history. Read More

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http://dx.doi.org/10.3892/br.2020.1282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100128PMC

S100B as a biomarker for brain metastases in patients with non-small cell lung cancer.

Biomed Rep 2020 Apr 11;12(4):204-208. Epub 2020 Feb 11.

Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.

Brain metastases are frequent in patients with lung cancer and a major cause of morbidity and mortality. Finding a biomarker predicting brain metastases could facilitate early start of treatment and thereby reduce morbidity and possibly improve overall survival. Previous studies suggest S100B as a possible biomarker for this purpose. Read More

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http://dx.doi.org/10.3892/br.2020.1277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054701PMC

Clinical and economic effect of administration of red blood product transfusions in an outpatient supportive care cancer service.

Biomed Rep 2020 Apr 10;12(4):199-203. Epub 2020 Feb 10.

Medical Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, I-56126 Pisa, Italy.

Patients with cancer may develop disease- or treatment-associated anemia, requiring red blood product transfusions. In Italy, transfusions are usually administered in a day hospital service or in inpatient wards. Since 2013, a dedicated supportive care service for outpatients has been implemented in Pisa, where red blood product transfusions are administered. Read More

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http://dx.doi.org/10.3892/br.2020.1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054705PMC

IL-8 and LYPD8 expression levels are associated with the inflammatory response in the colon of patients with ulcerative colitis.

Biomed Rep 2020 Apr 20;12(4):193-198. Epub 2020 Feb 20.

Division of Medicine and Clinical Science, Faculty of Medicine Tottori University, Yonago, Tottori 683-8504, Japan.

Ulcerative colitis (UC) is an idiopathic chronic inflammatory disorder affecting the large intestine, which may involve mucosal degeneration. Glycoproteins, mucin2 (MUC2) and the LY6/PLAUR domain containing 8 (LYPD8) are present on the mucous layer of the colon and can hinder the invasion of bacteria, thus contributing to the prevention of colitis. The present study investigated the expression levels of interleukin-8 (IL-8), MUC2 and LYPD8 on the mucous membranes of patients with UC. Read More

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http://dx.doi.org/10.3892/br.2020.1280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054700PMC

Identification of potential key genes in gastric cancer using bioinformatics analysis.

Biomed Rep 2020 Apr 20;12(4):178-192. Epub 2020 Feb 20.

Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, P.R. China.

Gastric cancer (GC) is one of the most common types of cancer worldwide. Patients must be identified at an early stage of tumor progression for treatment to be effective. The aim of the present study was to identify potential biomarkers with diagnostic value in patients with GC. Read More

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http://dx.doi.org/10.3892/br.2020.1281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054703PMC

Diagnostic value of circular RNAs in female reproductive system diseases: A PRISMA-compliant meta-analysis.

Biomed Rep 2020 Apr 12;12(4):171-177. Epub 2020 Feb 12.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.

Circular RNAs (circRNAs) are novel non-coding RNAs that have been reported to be involved in the progression of numerous diseases. However, the clinical diagnostic value of circRNAs in female reproductive system diseases remains unknown. The present study is a systemic review and meta-analysis of the available literature on circRNAs as novel biomarkers for female reproductive system diseases. Read More

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http://dx.doi.org/10.3892/br.2020.1278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054704PMC

Extracellular vesicles from senescent hepatic stellate cells promote cell viability of hepatoma cells through increasing EGF secretion from differentiated THP-1 cells.

Biomed Rep 2020 Apr 14;12(4):163-170. Epub 2020 Feb 14.

Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.

Since the discovery of the senescence-associated secretory phenotype, the role of senescent hepatic stellate cells (HSCs) in hepatocellular carcinoma (HCC) development has gained increasing attention. Similar to cytokines, extracellular vesicles (EVs) are essential for intercellular communication. However, the function of EVs derived from senescent HSCs in HCC progression has not been extensively studied. Read More

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http://dx.doi.org/10.3892/br.2020.1279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054706PMC

and genetic polymorphisms and their association with antituberculosis drug-induced liver injury.

Biomed Rep 2020 Apr 10;12(4):153-162. Epub 2020 Feb 10.

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.

Antituberculosis (anti-TB) drugs are the most common cause of drug-induced liver injury (DILI). There are numerous studies revealing the associations between the polymorphisms of pharmacogenes and the risk of anti-TB DILI (ATDILI). In the present study, relevant studies regarding the pharmacogenes associated with ATDILI were systematically searched in PubMed and Scopus. Read More

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http://dx.doi.org/10.3892/br.2020.1275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054707PMC

Types of acute phase reactants and their importance in vaccination.

Biomed Rep 2020 Apr 11;12(4):143-152. Epub 2020 Feb 11.

Office of Vaccines, Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993, USA.

Vaccines are considered to be one of the most cost-effective life-saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade-offs. Trade-offs are more potent immune responses which may be potentially difficult to separate from potent acute phase reactions. Read More

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http://dx.doi.org/10.3892/br.2020.1276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054702PMC

Diagnosis of a case of homozygous constitutional MMR-deficiency by the use of a gene-panel in a non-consanguineous family: A case report.

Biomed Rep 2020 Mar 20;12(3):134-138. Epub 2019 Dec 20.

Department of Colorectal and Anal Surgery, The 940th Hospital of Joint Logistics Support Force of The Chinese People's Liberation Army, Lanzhou, Gansu 730050, P.R. China.

Constitutional MMR-deficiency syndrome (CMMRD) is a rare but severe hereditary syndrome of pediatric cancer caused by bi-allelic pathogenic variants in one of the mismatch DNA repair genes (MMR): , , , and . This syndrome occurs when patients inherit altered alleles from both of their heterozygote parents affected by Lynch syndrome. In total, ~150 patients have been identified at present, the majority of which were Caucasian. Read More

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http://dx.doi.org/10.3892/br.2019.1268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006093PMC

Study of HSA interactions with arachidonic acid using spectroscopic methods revealing molecular dynamics of HSA-AA interactions.

Biomed Rep 2020 Mar 31;12(3):125-133. Epub 2019 Dec 31.

Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin 3419915315, Iran.

The interaction between human serum albumin (HSA) and arachidonic acid (AA) as an unsaturated fatty acid were investigated in the present study using methods including UV-VIS spectrophotometry, fluorescence and circular dichroism (CD) spectroscopy, lifetime measurements, fluorescence anisotropy measurements and visual molecular dynamics (MD). The thermodynamic parameters were assessed from HSA thermal and chemical denaturation in the presence and absence of AA. From the thermal denaturation, the T and ΔG˚ magnitudes obtained were 327. Read More

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http://dx.doi.org/10.3892/br.2019.1270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006104PMC

Long-term maintenance of nutritional status with ninjinyoueito in terminal patients with chronic respiratory disease: Two case reports.

Biomed Rep 2020 Mar 20;12(3):121-124. Epub 2019 Dec 20.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Ibaraki 310-0015, Japan.

Ninjinyoeito, is a traditional herbal (Kampo) medicine which is administered to patients with debilitating diseases in North-East Asia. Ninjinyoeito has been reported to be effective against loss of physical strength, fatigue and loss of appetite in patients with wasting diseases. The present study described long-term maintenance of body weight with ninjinyoueito in 2 terminal patients with chronic respiratory diseases. Read More

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http://dx.doi.org/10.3892/br.2019.1267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006135PMC

Anti-angiogenic and anti-proliferative effects of Benja-ummarit extract in rats with hepatocellular carcinoma.

Biomed Rep 2020 Mar 16;12(3):109-120. Epub 2020 Jan 16.

Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.

The herbal extract Benja-ummarit (BU) is a traditional Thai medicine with a putative cancer-suppressing effect. However, this effect has only been tested in human hepatocarcinoma cell lines. The present study determined the efficacy of a BU extract to treat hepatocellular carcinoma (HCC) in rats and established its anti-angiogenic and anti-proliferative properties. Read More

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http://dx.doi.org/10.3892/br.2020.1272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006111PMC

Sulfur-containing amino acids in aged garlic extract inhibit inflammation in human gingival epithelial cells by suppressing intercellular adhesion molecule-1 expression and IL-6 secretion.

Biomed Rep 2020 Mar 30;12(3):99-108. Epub 2019 Dec 30.

Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Akitakata, Hiroshima 739-1195, Japan.

Aged garlic extract (AGE) contains various biologically active sulfur-containing amino acids, such as -allylcysteine (SAC), -1-propenylcysteine (S1PC) and -allylmercaptocysteine (SAMC). These amino acids have been demonstrated to lower hypertension, improve atherosclerosis and enhance immunity through their anti-inflammatory and antioxidant activities. It was recently reported that the administration of AGE alleviated gingivitis in a clinical trial. Read More

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http://dx.doi.org/10.3892/br.2019.1269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006171PMC

Indices calculated by serum creatinine and cystatin C as predictors of liver damage, muscle strength and sarcopenia in liver disease.

Biomed Rep 2020 Mar 24;12(3):89-98. Epub 2020 Jan 24.

Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.

Serum creatinine (Cr)-based glomerular filtration rate (CrGFR) is overestimated in liver disease. The present study evaluated whether the difference in CrGFR and cystatin C (CysC) GFR (dGFR) is significant in liver disease. The Cr-to-CysC ratio and sarcopenia index (SI) have been reported to correlate with muscle volume. Read More

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http://dx.doi.org/10.3892/br.2020.1273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006091PMC

Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.

Biomed Rep 2020 Mar 20;12(3):83-88. Epub 2019 Dec 20.

Second Department of Gynecology, Medical University of Lublin, PL-20954 Lublin, Poland.

Infertility and fecundity problems concern 10-18% of partners in their reproductive years compromising around one million females and males in Poland. Research and analysis of factors that affect male fertility are limited, especially, regarding the age of the father and determining the age at which quality of semen decreases. Age of the father has greater impact than maternal age, on cases of sporadic autosomal dominant congenital diseases such as Apert, Crouzon, Pfeiffer, Noonan and Costello syndromes, multiple endocrine neoplasia (types 2A and 2B) and achondroplasia. Read More

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http://dx.doi.org/10.3892/br.2019.1266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006092PMC

Serum parathyroid hormone levels in patients with chronic right heart failure.

Biomed Rep 2020 Feb 3;12(2):73-79. Epub 2019 Dec 3.

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215002, P.R. China.

Parathyroid hormone (PTH) is a novel cardiovascular biomarker which is particularly useful for detection and assessment of heart failure (HF). However, previous studies examining PTH in heart failure have primarily focused on left HF; thus, the relationship between PTH and right HF remains unclear. The aim of the present study was to evaluate the serum PTH levels in patients with chronic right HF. Read More

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http://dx.doi.org/10.3892/br.2019.1262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951227PMC
February 2020

Bariatric surgery results in restoration of physiological plasma levels of pentraxine-3.

Biomed Rep 2020 Feb 3;12(2):68-72. Epub 2019 Dec 3.

Medical Research Institute, Evangelical Mackenzie University, Curitiba, Paraná 80730-000, Brazil.

Pentraxine-3 (PTX3) is a member of the humoral innate immune system and serves a role in protection against infections, inflammation control and matrix deposition. The aim of the present study was to measure the PTX3 levels in obese patients and its association with glycemic and lipid profiles, and to analyze the effects of weight loss provided by bariatric surgery in serum PTX3 levels. PTX3 was measured in 84 obese patients whom underwent bariatric surgery and 94 healthy controls. Read More

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http://dx.doi.org/10.3892/br.2019.1264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951114PMC
February 2020

Palliative radiotherapy in advanced cancer patients treated with immune-checkpoint inhibitors: The PRACTICE study.

Biomed Rep 2020 Feb 13;12(2):59-67. Epub 2019 Dec 13.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, I-67100 L'Aquila, Italy.

In the present study, the influence of purely palliative radiotherapy (pRT) on the outcomes of patients with advanced cancer undergoing immune checkpoint blockade was evaluated. Patients were stratified into three groups: Patients who had received pRT within 6 months prior to the initiation of immunotherapy (previous pRT); patients who received pRT during immunotherapy (concurrent pRT); and patients who did not receive RT prior to or during immunotherapy (no RT group), and these groups were compared. The median overall survival (mOS), median progression free survival (mPFS) and median time-to-treatment failure (mTTF) for the previous pRT group were significantly shorter compared with the no RT group (mOS, 3. Read More

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http://dx.doi.org/10.3892/br.2019.1265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951237PMC
February 2020

Molecular epidemiology of hepatitis A outbreaks in two districts in Indonesia in 2018: Same subtype, but different strains.

Biomed Rep 2020 Feb 27;12(2):51-58. Epub 2019 Nov 27.

Faculty of Medicine, Airlangga University, Surabaya, East Java 60131, Indonesia.

The present study aimed to analyse molecular epidemiological data from hepatitis A virus (HAV) outbreaks in two affected areas. The association between the knowledge of hepatitis A and incidence of infection was also determined. Serum samples were obtained from 88 individuals with clinical manifestations of acute hepatitis in Lamongan (n=54) in January 2018 and Bangkalan (n=34) in March 2018. Read More

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http://dx.doi.org/10.3892/br.2019.1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951258PMC
February 2020

A novel variant of contributes to merosin deficient congenital muscular dystrophy type 1A: Case report.

Biomed Rep 2020 Feb 27;12(2):46-50. Epub 2019 Nov 27.

Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec International Hospital, Hanoi 100000, Vietnam.

Merosin deficient congenital muscular dystrophy type 1A (MDC1A) is caused by defects in the gene. Patients with MDC1A exhibit severe symptoms, including congenital hypotonia, delayed motor development and contractures. The present case report describes a Vietnamese male child with clinical manifestations of delayed motor development, limb-girdle muscular dystrophy, severe scoliosis and white matter abnormality in the brain. Read More

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http://dx.doi.org/10.3892/br.2019.1260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951223PMC
February 2020

Inorganic mercury-induced MIP-2 expression is suppressed by N-acetyl-L-cysteine in RAW264.7 macrophages.

Biomed Rep 2020 Feb 3;12(2):39-45. Epub 2019 Dec 3.

Department of Environment and Public Health, National Institute for Minamata Disease, Minamata, Kumamoto 867-0008, Japan.

Macrophages play an important role in neurotoxicity caused by methylmercury exposure through inflammatory responses. Methylmercury is known to demethylate to inorganic mercury in the brain, and macrophages are likely to be involved in this process. However, the inflammatory responses of macrophages against exposure to inorganic mercury are unclear. Read More

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http://dx.doi.org/10.3892/br.2019.1263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951253PMC
February 2020