24,595 results match your criteria Biomedical physics & engineering express[Journal]


A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens.

Sci Rep 2019 Apr 19;9(1):6327. Epub 2019 Apr 19.

Department of Biomedical Sciences, The University of Hull, Cottingham Road, Hull, UK.

Development of personalised cancer models to predict response to radiation would benefit patient care; particularly in malignancies where treatment resistance is prevalent. Herein, a robust, easy to use, tumour-on-a-chip platform which maintains precision cut head and neck cancer for the purpose of ex vivo irradiation is described. The device utilises sintered discs to separate the biopsy and medium, mimicking in vivo microvascular flow and diffusion, maintaining tissue viability for 68 h. Read More

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http://www.nature.com/articles/s41598-019-42745-2
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http://dx.doi.org/10.1038/s41598-019-42745-2DOI Listing
April 2019
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Comparison of Micro-Mixing in Time Pulsed Newtonian Fluid and Viscoelastic Fluid.

Micromachines (Basel) 2019 Apr 18;10(4). Epub 2019 Apr 18.

School of Energy Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.

Fluid mixing plays an essential role in many microfluidic applications. Here, we compare the mixing in time pulsing flows for both a Newtonian fluid and a viscoelastic fluid at different pulsing frequencies. In general, the mixing degree in the viscoelastic fluid is higher than that in the Newtonian fluid. Read More

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https://www.mdpi.com/2072-666X/10/4/262
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http://dx.doi.org/10.3390/mi10040262DOI Listing
April 2019
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Commercial kitchenware glass as a potential thermoluminescent media for retrospective dosimetry.

Appl Radiat Isot 2019 Apr 7;148:218-224. Epub 2019 Apr 7.

Centre for Biomedical Physics, School of Healthcare and Medical Sciences, Sunway University, 47500, Bandar Sunway, Selangor, Malaysia; Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Study has been made of the thermoluminescence (TL) yield of various glass-based commercial kitchenware (Reko-China, Skoja-France, Godis-China, Glass Tum-Malaysia, Lodrat-France). Interest focuses on their potential for retrospective dosimetry. Use was made of aCo gamma-ray irradiator, delivering doses in the range 2-10 Gy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698043183121
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http://dx.doi.org/10.1016/j.apradiso.2019.04.001DOI Listing
April 2019
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Impact of Intracranial Aneurysm Morphology and Rupture Status on the Particle Residence Time.

J Neuroimaging 2019 Apr 19. Epub 2019 Apr 19.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background And Purpose: Aneurysm hemodynamics play an important role in aneurysm growth and subsequent rupture. Within the available hemodynamic characteristics, particle residence time (PRT) is relatively unexplored. However, some studies have shown that PRT is related to thrombus formation and inflammation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12618
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http://dx.doi.org/10.1111/jon.12618DOI Listing
April 2019
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A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies.

PLoS One 2019 19;14(4):e0215447. Epub 2019 Apr 19.

School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

An improved red blood cell (RBC) membrane model is developed based on the bilayer coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte-echinocyte (SDE) transformation of a RBC. The coarse-grained (CG)-RBC membrane model is proposed to predict the minimum energy configuration of the RBC from the competition between lipid-bilayer bending resistance and cytoskeletal shear resistance under given reference constraints. In addition to the conventional membrane surface area, cell volume and bilayer-leaflet-area-difference constraints, a new constraint: total-membrane-curvature is proposed in the model to better predict RBC shapes in agreement with experimental observations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215447PLOS
April 2019
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Imaging localized neuronal activity at fast time scales through biomechanics.

Sci Adv 2019 Apr 17;5(4):eaav3816. Epub 2019 Apr 17.

School of Biomedical Engineering and Imaging Sciences, Kings College London, London, UK.

Mapping neuronal activity noninvasively is a key requirement for in vivo human neuroscience. Traditional functional magnetic resonance (MR) imaging, with a temporal response of seconds, cannot measure high-level cognitive processes evolving in tens of milliseconds. To advance neuroscience, imaging of fast neuronal processes is required. Read More

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aav
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http://dx.doi.org/10.1126/sciadv.aav3816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469937PMC
April 2019
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Cross-Polarization Optical Coherence Tomography for Brain Tumor Imaging.

Front Oncol 2019 2;9:201. Epub 2019 Apr 2.

Laboratory of Optical Coherence Tomography, Research Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT)-OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. The study was performed on 176 human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three "single-blinded" investigators. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00201/
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http://dx.doi.org/10.3389/fonc.2019.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455095PMC
April 2019
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Identifying Disease-Gene Associations With Graph-Regularized Manifold Learning.

Front Genet 2019 2;10:270. Epub 2019 Apr 2.

Division of Biomedical Engineering, University of Saskatchewan Saskatoon, SK Canada.

Complex diseases are known to be associated with disease genes. Uncovering disease-gene associations is critical for diagnosis, treatment, and prevention of diseases. Computational algorithms which effectively predict candidate disease-gene associations prior to experimental proof can greatly reduce the associated cost and time. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00270
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http://dx.doi.org/10.3389/fgene.2019.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454152PMC
April 2019
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Extended Bidomain Modeling of Defibrillation: Quantifying Virtual Electrode Strengths in Fibrotic Myocardium.

Front Physiol 2019 3;10:337. Epub 2019 Apr 3.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States.

Defibrillation is a well-established therapy for atrial and ventricular arrhythmia. Here, we shed light on defibrillation in the fibrotic heart. Using the extended bidomain model of electrical conduction in cardiac tissue, we assessed the influence of fibrosis on the strength of virtual electrodes caused by extracellular electrical current. Read More

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http://dx.doi.org/10.3389/fphys.2019.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456788PMC

Efficient Deep Network Architectures for Fast Chest X-Ray Tuberculosis Screening and Visualization.

Sci Rep 2019 Apr 18;9(1):6268. Epub 2019 Apr 18.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany.

Automated diagnosis of tuberculosis (TB) from chest X-Rays (CXR) has been tackled with either hand-crafted algorithms or machine learning approaches such as support vector machines (SVMs) and convolutional neural networks (CNNs). Most deep neural network applied to the task of tuberculosis diagnosis have been adapted from natural image classification. These models have a large number of parameters as well as high hardware requirements, which makes them prone to overfitting and harder to deploy in mobile settings. Read More

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http://www.nature.com/articles/s41598-019-42557-4
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http://dx.doi.org/10.1038/s41598-019-42557-4DOI Listing
April 2019
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Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies.

Science 2019 Apr 18. Epub 2019 Apr 18.

Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA 02215, USA.

Eukaryotic genes are regulated by multivalent transcription factor complexes. Through cooperative self-assembly, these complexes perform non-linear regulatory operations involved in cellular decision-making and signal processing. Here, we apply this design principle to synthetic networks, testing whether engineered cooperative assemblies can program non-linear gene circuit behavior in yeast. Read More

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http://www.sciencemag.org/lookup/doi/10.1126/science.aau8287
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http://dx.doi.org/10.1126/science.aau8287DOI Listing
April 2019
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Early survival prediction in non-small cell lung cancer from PET/CT images using an intra-tumor partitioning method.

Phys Med 2019 Apr 27;60:58-65. Epub 2019 Mar 27.

KTH Royal Institute of Technology, Department of Biomedical Engineering and Health Systems, Hälsovägen 11C, SE-14157 Huddinge, Sweden.

Purpose: To explore prognostic and predictive values of a novel quantitative feature set describing intra-tumor heterogeneity in patients with lung cancer treated with concurrent and sequential chemoradiotherapy.

Methods: Longitudinal PET-CT images of 30 patients with non-small cell lung cancer were analysed. To describe tumor cell heterogeneity, the tumors were partitioned into one to ten concentric regions depending on their sizes, and, for each region, the change in average intensity between the two scans was calculated for PET and CT images separately to form the proposed feature set. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797193006
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http://dx.doi.org/10.1016/j.ejmp.2019.03.024DOI Listing
April 2019
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Reinforcement learning meets minority game: Toward optimal resource allocation.

Phys Rev E 2019 Mar;99(3-1):032302

School of Electrical, Computer and Energy Engineering, Department of Physics, Arizona State University, Tempe, Arizona 85287, USA.

The main point of this paper is to provide an affirmative answer through exploiting reinforcement learning (RL) in artificial intelligence (AI) for eliminating herding without any external control in complex resource allocation systems. In particular, we demonstrate that when agents are empowered with RL (e.g. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.032302DOI Listing

Corrected pair correlation functions for environments with obstacles.

Phys Rev E 2019 Mar;99(3-1):032124

Systems Biology Laboratory, School of Mathematics and Statistics, and Department of Biomedical Engineering, University of Melbourne, Parkville, Victoria 3010, Australia.

Environments with immobile obstacles or void regions that inhibit and alter the motion of individuals within that environment are ubiquitous. Correlation in the location of individuals within such environments arises as a combination of the mechanisms governing individual behavior and the heterogeneous structure of the environment. Measures of spatial structure and correlation have been successfully implemented to elucidate the roles of the mechanisms underpinning the behavior of individuals. Read More

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https://link.aps.org/doi/10.1103/PhysRevE.99.032124
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http://dx.doi.org/10.1103/PhysRevE.99.032124DOI Listing
March 2019
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Exposure effects of endotoxin-free titanium-based wear particles to human osteoblasts.

J Mech Behav Biomed Mater 2019 Apr 10;95:143-152. Epub 2019 Apr 10.

Department of Physics, UNESP, São Paulo State University, 17033-360, Bauru, SP, Brazil.

Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, wear, and tribocorrosion. As a consequence, metallic ions or particles (debris) may be released, and although several studies have been conducted in recent years to better understand the effects of their exposure to living cells, a consensual opinion has not yet been obtained. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161193028
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http://dx.doi.org/10.1016/j.jmbbm.2019.04.003DOI Listing
April 2019
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Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing
April 2019
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On the critical evaluation and confirmation of germline sequence variants identified using massively parallel sequencing.

J Biotechnol 2019 Apr 15. Epub 2019 Apr 15.

Institute for Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia; Geneton Ltd., Bratislava, Slovakia. Electronic address:

Although massively parallel sequencing (MPS) is becoming common practice in both research and routine clinical care, confirmation requirements of identified DNA variants using alternative methods are still topics of debate. When evaluating variants directly from MPS data, different read depth statistics, together with specialized genotype quality scores are, therefore, of high relevance. Here we report results of our validation study performed in two different ways: 1) confirmation of MPS identified variants using Sanger sequencing; and 2) simultaneous Sanger and MPS analysis of exons of selected genes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.013DOI Listing
April 2019
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Molecular machinery providing copper bioavailability for spermatozoa along the epididymial tubule in mouse.

Biol Reprod 2019 Feb 19. Epub 2019 Feb 19.

Department of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Kraków, Poland.

Progressive functional maturation of spermatozoa is completed during the transit of these cells through the epididymis, a tubule structure connecting a testicle to a vas deferens. Epididymal epithelial cells by means of their secretory and absorptive functions determine a highly specialized luminal microenvironment containing multiple organic and inorganic components. The latter include copper ions, which due to their redox properties are indispensable for critical homeostatic processes occurring in spermatozoa floating in different part of epididymis but can be potentially toxic. Read More

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https://academic.oup.com/biolreprod/advance-article/doi/10.1
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http://dx.doi.org/10.1093/biolre/ioz028DOI Listing
February 2019
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An essential descriptor for the oxygen evolution reaction on reducible metal oxide surfaces.

Chem Sci 2019 Mar 1;10(11):3340-3345. Epub 2019 Feb 1.

Department of Physics , Southern University of Science and Technology , Shenzhen 518055 , China . Email:

The development of a universal activity descriptor like the d-band model for transition metal catalysts is of great importance to catalyst design. However, due to the complicated electronic structures of metal oxides, the correlation of the binding energies of reaction intermediates (*OH, *O, and *OOH) in the oxygen evolution reaction (OER) with experimentally controllable properties of metal oxides has not been well established. Here we demonstrate that excess electrons are the essential factor that governs the binding properties of intermediates on the surfaces of reducible metal oxides. Read More

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http://dx.doi.org/10.1039/c8sc04521fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430015PMC

Emerging quantitative MRI biomarkers of diffuse liver disease.

Clin Liver Dis (Hoboken) 2014 Dec 20;4(6):129-132. Epub 2015 Jan 20.

Department of Radiology University of Wisconsin-Madison Madison WI.

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http://dx.doi.org/10.1002/cld.424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448753PMC
December 2014

Primer on magnetic resonance imaging of the liver.

Clin Liver Dis (Hoboken) 2014 Nov 9;4(5):120-123. Epub 2014 Dec 9.

Department of Radiology University of Wisconsin-Madison Madison WI.

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http://doi.wiley.com/10.1002/cld.440
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http://dx.doi.org/10.1002/cld.440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448751PMC
November 2014
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ADAM phantom to test 4D medical imaging and dose delivery devices.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Agricultural, Food and Forestry System, Universita di Firenze, Florence, ITALY.

Radiotherapy treatment of moving lesions is a challenging task in which different strategies can be used. The clinical implementation of the variety of complex technical solutions pursued to treat cancer, while sparing healthy tissues, requires accurate quality assurance tests and adequate phantoms. The aim of this work is to report on the Anthropomorphic Dynamic breAthing Model (ADAM) and on its applications to test image quality and dose delivery for four-dimensional (4D) techniques used to compensate for breathing-induced tumor motion. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1a49
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http://dx.doi.org/10.1088/1361-6560/ab1a49DOI Listing
April 2019
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Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.

J Drug Target 2019 Apr 17:1-25. Epub 2019 Apr 17.

b Medical Physics & Biomedical Engineering, University College London , Gower, Street , London , UK.

Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of diabetic PNP (DPNP) are poorly understood. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1608552DOI Listing
April 2019
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Automatic stratification of prostate tumour aggressiveness using multiparametric MRI: a horizontal comparison of texture features.

Acta Oncol 2019 Apr 17:1-9. Epub 2019 Apr 17.

a The Sir Peter MacCallum Department of Oncology , The University of Melbourne , Melbourne , Australia.

Background: Previous studies have identified apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can stratify prostate cancer into high- and low-grade disease (HG and LG, respectively). In this study, we consider the improvement of incorporating texture features (TFs) from T2-weighted (T2w) multiparametric magnetic resonance imaging (mpMRI) relative to mpMRI alone to predict HG and LG disease.

Material And Methods: In vivo mpMRI was acquired from 30 patients prior to radical prostatectomy. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1598576DOI Listing

Can we reduce the workload of mammographic screening by automatic identification of normal exams with artificial intelligence? A feasibility study.

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload.

Methods And Materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC ROC) studies. An AI system was used to obtain a score between 1 and 10 for each exam, representing the likelihood of cancer present. Read More

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http://link.springer.com/10.1007/s00330-019-06186-9
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http://dx.doi.org/10.1007/s00330-019-06186-9DOI Listing
April 2019
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Microfluidic multipoles theory and applications.

Nat Commun 2019 Apr 16;10(1):1781. Epub 2019 Apr 16.

Institut de Génie Biomédical, École Polytechnique de Montréal, Montréal, QC, H3T 1J4, Canada.

Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. Read More

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http://dx.doi.org/10.1038/s41467-019-09740-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467910PMC

Generation of spatiotemporally tailored terahertz wavepackets by nonlinear metasurfaces.

Nat Commun 2019 Apr 16;10(1):1778. Epub 2019 Apr 16.

Department of Physical Electronics, School of Electrical Engineering, Tel-Aviv University, 6997801, Tel Aviv, Israel.

The past two decades have witnessed an ever-growing number of emerging applications that utilize terahertz (THz) waves, ranging from advanced biomedical imaging, through novel security applications, fast wireless communications, and new abilities to study and control matter in all of its phases. The development and deployment of these emerging technologies is however held back, due to a substantial lack of simple methods for efficient generation, detection and manipulation of THz waves. Recently it was shown that uniform nonlinear metasurfaces can efficiently generate broadband single-cycle THz pulses. Read More

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http://dx.doi.org/10.1038/s41467-019-09811-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467996PMC

Selective photoelectrochemical oxidation of glycerol to high value-added dihydroxyacetone.

Nat Commun 2019 Apr 16;10(1):1779. Epub 2019 Apr 16.

School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore.

It is highly profitable to transform glycerol - the main by-product from biodiesel production to high value-added chemicals. In this work, we develop a photoelectrochemical system based on nanoporous BiVO for selective oxidation of glycerol to 1,3-dihydroxyacetone - one of the most valuable derivatives of glycerol. Under AM 1. Read More

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http://www.nature.com/articles/s41467-019-09788-5
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http://dx.doi.org/10.1038/s41467-019-09788-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467901PMC
April 2019
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Integrated Printed Microfluidic Biosensors.

Trends Biotechnol 2019 Apr 13. Epub 2019 Apr 13.

Biosensors and Bioelectronics Centre, Department of Physics, Chemistry and Biology (IFM), Linköping University, 58183, Linköping, Sweden. Electronic address:

Integrated printed microfluidic biosensors are one of the most recent point-of-care (POC) sensor developments. Fast turnaround time for production and ease of customization, enabled by the integration of recognition elements and transducers, are key for on-site biosensing for both healthcare and industry and for speeding up translation to real-life applications. Here, we provide an overview of recent progress in printed microfluidics, from the 2D to the 4D level, accompanied by novel sensing element integration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677799193005
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http://dx.doi.org/10.1016/j.tibtech.2019.03.009DOI Listing
April 2019
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The 2019 Mathematical Oncology Roadmap.

Phys Biol 2019 Apr 16. Epub 2019 Apr 16.

Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, Ohio, UNITED STATES.

Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology, Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is no denying that mathematics continues to play an increasingly prominent role in cancer research. Mathematical Oncology-defined here simply as the use of mathematics in cancer research-complements and overlaps with a number of other fields that rely on mathematics as a core methodology. As a result, Mathematical Oncology has a broad scope, ranging from theoretical studies to clinical trials designed with mathematical models. Read More

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http://dx.doi.org/10.1088/1478-3975/ab1a09DOI Listing
April 2019
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Fluid surface coatings for solid-state nanopores: comparison of phospholipid bilayers and archaea-Inspired lipid monolayers.

Nanotechnology 2019 Apr 16. Epub 2019 Apr 16.

Universite de Fribourg Adolphe Merkle Institute, Fribourg, SWITZERLAND.

In the context of sensing and characterizing single proteins with synthetic nanopores, lipid bilayer coatings provide at least four benefits: First, they minimize unwanted protein adhesion to the pore walls by exposing a zwitterionic, fluid surface. Second, they can slow down protein translocation and rotation by the opportunity to tether proteins with a lipid anchor to the fluid bilayer coating. Third, they provide the possibility to impart analyte specificity by including lipid anchors with a specific receptor or ligand in the coating. Read More

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http://dx.doi.org/10.1088/1361-6528/ab19e6DOI Listing
April 2019
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Sustainable synthesis and remarkable adsorption capacity of MOF/graphene oxide and MOF/CNT based hybrid nanocomposites for the removal of Bisphenol A from water.

Sci Total Environ 2019 Mar 27;673:306-317. Epub 2019 Mar 27.

Department of Chemistry, University of Texas at El Paso, El Paso, TX 79968, United States; Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment, The University of Texas at El Paso, El Paso, TX, United States. Electronic address:

A series of novel absorbents based on Cu-BDC MOFs decorated over graphene oxide (GrO) and carbon nanotubes (CNTs) hybrid nanocomposites, namely Cu-BDC@GrO and Cu-BDC@CNT, are synthesized via a facile and one-pot green solvothermal method for water remediation. The nanocomposites were characterized by XRD, TEM, SEM, EDS, Raman, FTIR, TGA, XPS, Zetasizer and ICP-OES instruments. XRD results confirmed the high crystalline structure of the synthesized hybrid nanocomposites. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.219DOI Listing

Poly(propylene fumarate)-based materials: Synthesis, functionalization, properties, device fabrication and biomedical applications.

Biomaterials 2019 Mar 28;208:45-71. Epub 2019 Mar 28.

Department of Plastic & Reconstructive Surgery, The Ohio State University, Columbus, OH 43210, United States. Electronic address:

Poly(propylene fumarate) (PPF) is a biodegradable polymer that has been investigated extensively over the last three decades. It has led many scientists to synthesize and fabricate a variety of PPF-based materials for biomedical applications due to its controllable mechanical properties, tunable degradation and biocompatibility. This review provides a comprehensive overview of the progress made in improving PPF synthesis, resin formulation, crosslinking, device fabrication and post polymerization modification. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193018
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http://dx.doi.org/10.1016/j.biomaterials.2019.03.038DOI Listing
March 2019
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Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern.

Elife 2019 Apr 16;8. Epub 2019 Apr 16.

Developmental Biology Program, Sloan Kettering Institute, New York, United States.

Models based in differential expansion of elastic material, axonal constraints, directed growth, or multi-phasic combinations have been proposed to explain brain folding. However, the cellular and physical processes present during folding have not been defined. We used the murine cerebellum to challenge folding models with in vivo data. Read More

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http://dx.doi.org/10.7554/eLife.45019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467563PMC

3D Super-Resolution US Imaging of Rabbit Lymph Node Vasculature in Vivo by Using Microbubbles.

Radiology 2019 Apr 16:182593. Epub 2019 Apr 16.

From the Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, England (J.Z., E.M.R., S.H., K.R., C.H.L., G.Z., P.D.W., M.X.T.); Department of Surgery, Maidstone and Tunbridge Wells NHS Trust, Maidstone, England (K.C.); Department of Imaging, Charing Cross Hospital, Fulham Palace Rd, London, England (A.L.); Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Science, Kings College London, London, England (K.C.J., J.B., R.J.E.); Department of Physics and Centre for Pathology, Imperial College London, London, England (C.D.); and Department of Imaging, Natural History Museum, London, England (B.C.).

Background Variations in lymph node (LN) microcirculation can be indicative of metastasis. The identification and quantification of metastatic LNs remains essential for prognosis and treatment planning, but a reliable noninvasive imaging technique is lacking. Three-dimensional super-resolution (SR) US has shown potential to noninvasively visualize microvascular networks in vivo. Read More

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http://dx.doi.org/10.1148/radiol.2019182593DOI Listing
April 2019
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Biomechanical properties of red blood cells infected by Plasmodium berghei ANKA.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Malaria is a pathogenic disease in mammal species and typically causes destruction of red blood cells (RBCs). The malaria-infected RBCs undergoes alterations in morphology and its rheological properties, and the altered rheological properties of RBCs have a significant impact on disease pathophysiology. In this study, we investigated detailed topological and biomechanical properties of RBCs infected with malaria Plasmodium berghei ANKA using atomic force microscopy. Read More

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http://dx.doi.org/10.1002/jcp.28654DOI Listing

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines.

EJNMMI Phys 2019 Apr 16;6(1). Epub 2019 Apr 16.

Department of Radiology and Medical Physics, Hospital de Sant Pau, Barcelona, Spain.

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http://dx.doi.org/10.1186/s40658-018-0237-4DOI Listing

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines.

EJNMMI Res 2019 Apr 16;9(1):34. Epub 2019 Apr 16.

Department of Radiology and Medical Physics, Hospital de Sant Pau, Barcelona, Spain.

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http://dx.doi.org/10.1186/s13550-018-0469-2DOI Listing

Endorsement of International Consensus Radiochemistry Nomenclature Guidelines.

Eur J Nucl Med Mol Imaging 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology and Medical Physics, Hospital de Sant Pau, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00259-018-4243-5DOI Listing

Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization.

Sci Adv 2019 Mar 29;5(3):eaav9075. Epub 2019 Mar 29.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical University, Xi' an, Shaanxi, PR China.

Contemporary models of intrafibrillar mineralization mechanisms are established using collagen fibrils as templates without considering the contribution from collagen-bound apatite nucleation inhibitors. However, collagen matrices destined for mineralization in vertebrates contain bound matrix proteins for intrafibrillar mineralization. Negatively charged, high-molecular weight polycarboxylic acid is cross-linked to reconstituted collagen to create a model for examining the contribution of collagen-ligand interaction to intrafibrillar mineralization. Read More

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aav
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http://dx.doi.org/10.1126/sciadv.aav9075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459768PMC
March 2019
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Intraoperative 360-deg three-dimensional transvaginal ultrasound during needle insertions for high-dose-rate transperineal interstitial gynecologic brachytherapy of vaginal tumors.

J Med Imaging (Bellingham) 2019 Apr 8;6(2):025001. Epub 2019 Apr 8.

University of Western Ontario, School of Biomedical Engineering, London, Ontario, Canada.

Brachytherapy, a type of radiotherapy, may be used to place radioactive sources into or in close proximity to tumors, providing a method for conformally escalating dose in the tumor and the local area surrounding the malignancy. High-dose-rate interstitial brachytherapy of vaginal tumors requires precise placement of multiple needles through holes in a plastic perineal template to deliver treatment while optimizing dose and avoiding overexposure of nearby organs at risk (OARs). Despite the importance of needle placement, image guidance for adaptive, intraoperative needle visualization, allowing misdirected needles to be identified and corrected during insertion, is not standard practice. Read More

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http://dx.doi.org/10.1117/1.JMI.6.2.025001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451200PMC

Author Correction: Evaluation of Hypoglycaemia with Non-Invasive Sensors in People with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia.

Sci Rep 2019 Apr 16;9(1):6347. Epub 2019 Apr 16.

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-42218-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465255PMC
April 2019
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Unified energetics analysis unravels SpCas9 cleavage activity for optimal gRNA design.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Department of Physics, University of Missouri, Columbia, MO 65211;

While CRISPR/Cas9 is a powerful tool in genome engineering, the on-target activity and off-target effects of the system widely vary because of the differences in guide RNA (gRNA) sequences and genomic environments. Traditional approaches rely on separate models and parameters to treat on- and off-target cleavage activities. Here, we demonstrate that a free-energy scheme dominates the Cas9 editing efficacy and delineate a method that simultaneously considers on-target activities and off-target effects. Read More

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http://dx.doi.org/10.1073/pnas.1820523116DOI Listing
April 2019
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3D reconstruction of diaphragmatic defects in CDH: a fetal MRI study.

Ultrasound Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Objectives: To assess the clinical feasibility and validity of fetal MRI-based 3D reconstructions to localize, classify, and quantify diaphragmatic defects in congenital diaphragmatic hernia (CDH).

Methods: Manual segmentation of the diaphragm based on 65 in vivo and four postmortem fetal MRI scans of 46 CDH cases (gestational age 16 - 38 gestational weeks (GW)) was performed using SSFP, T2-weighted, and T1-weighted sequences and ITK-Snap. The resultant 3D models of the fetal diaphragm and its defect(s) were validated by postmortem MRI segmentation in four cases and/or comparison to a reference classification based on autopsy and surgery reports. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20296
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http://dx.doi.org/10.1002/uog.20296DOI Listing
April 2019
2 Reads

Designing Metabolic Division of Labor in Microbial Communities.

mSystems 2019 Mar-Apr;4(2). Epub 2019 Apr 9.

Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.

Microbes face a trade-off between being metabolically independent and relying on neighboring organisms for the supply of some essential metabolites. This balance of conflicting strategies affects microbial community structure and dynamics, with important implications for microbiome research and synthetic ecology. A "gedanken" (thought) experiment to investigate this trade-off would involve monitoring the rise of mutual dependence as the number of metabolic reactions allowed in an organism is increasingly constrained. Read More

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http://msystems.asm.org/lookup/doi/10.1128/mSystems.00263-18
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http://dx.doi.org/10.1128/mSystems.00263-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456671PMC
April 2019
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Formation of Si/SiO Luminescent Quantum Dots From Mesoporous Silicon by Sodium Tetraborate/Citric Acid Oxidation Treatment.

Front Chem 2019 29;7:165. Epub 2019 Mar 29.

Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, CA, United States.

We propose a rapid, one-pot method to generate photoluminescent (PL) mesoporous silicon nanoparticles (PSiNPs). Typically, mesoporous silicon (meso-PSi) films, obtained by electrochemical etching of monocrystalline silicon substrates, do not display strong PL because the silicon nanocrystals (nc-Si) in the skeleton are generally too large to display quantum confinement effects. Here we describe an improved approach to form photoluminescent PSiNPs from meso-PSi by partial oxidation in aqueous sodium borate (borax) solutions. Read More

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http://dx.doi.org/10.3389/fchem.2019.00165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450366PMC

Neural Networks for Modeling Neural Spiking in S1 Cortex.

Front Syst Neurosci 2019 29;13:13. Epub 2019 Mar 29.

Department of Physiology, Northwestern University, Chicago, IL, United States.

Somatosensation is composed of two distinct modalities: touch, arising from sensors in the skin, and proprioception, resulting primarily from sensors in the muscles, combined with these same cutaneous sensors. In contrast to the wealth of information about touch, we know quite less about the nature of the signals giving rise to proprioception at the cortical level. Likewise, while there is considerable interest in developing encoding models of touch-related neurons for application to brain machine interfaces, much less emphasis has been placed on an analogous proprioceptive interface. Read More

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https://www.frontiersin.org/article/10.3389/fnsys.2019.00013
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http://dx.doi.org/10.3389/fnsys.2019.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449471PMC
March 2019
2 Reads

Combinatorial effects of radiofrequency hyperthermia and radiotherapy in the presence of magneto-plasmonic nanoparticles on MCF-7 breast cancer cells.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Radiation Biology Research Center, Iran University of Medical Science (IUMS), Tehran, Iran.

Here, the effects of combinatorial cancer therapy including radiotherapy (RT) and radiofrequency (RF) hyperthermia in the presence of gold-coated iron oxide nanoparticles (Au@IONPs), as a thermo-radio-sensitizer, are reported. The level of cell death and the ratio of Bax/Bcl2 genes, involved in the pathway of apoptosis, were measured to evaluate the synergistic effect of Au@IONPs-mediated RF hyperthermia and RT. MCF-7 human breast adenocarcinoma cells were treated with different concentrations of Au@IONPs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28599
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http://dx.doi.org/10.1002/jcp.28599DOI Listing
April 2019
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Monitoring the level of hypnosis using a hierarchical SVM system.

J Clin Monit Comput 2019 Apr 15. Epub 2019 Apr 15.

Department of Anesthesia, Waikato Hospital, Hamilton, Hamilton, New Zealand.

Monitoring level of hypnosis is a major ongoing challenge for anesthetists to reduce anesthetic drug consumption, avoiding intraoperative awareness and prolonged recovery. This paper proposes a novel automated method for accurate assessing of the level of hypnosis with sevoflurane in 17 patients using the electroencephalogram signal. In this method, a set of distinctive features and a hierarchical classification structure based on support vector machine (SVM) methods, is proposed to discriminate the four levels of anesthesia (awake, light, general and deep states). Read More

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http://link.springer.com/10.1007/s10877-019-00311-1
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http://dx.doi.org/10.1007/s10877-019-00311-1DOI Listing
April 2019
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Clinical trials in molecular radiotherapy-Tribulations and Triumphs Report of the NCRI CTRad meeting held at the Lift Islington, 8 June 2018.

Br J Radiol 2019 Apr 14:20190117. Epub 2019 Apr 14.

2 Joint Department of Physics, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research , Sutton, Surrey , UK.

It has been almost a decade since the commentary Molecular radiotherapy - the radionuclide raffle? by Gaze and Flux (2010) . The overarching feeling then was that no individual or organisation has taken up the challenge, nationally or internationally, of championing molecular radiotherapy in all its aspects. Here, we report on the recent NCRI-CTRad (Clinical Trials in Molecular Radiotherapy-Tribulations and Triumphs) meeting, held in London on the 8 June 2018. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20190117
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http://dx.doi.org/10.1259/bjr.20190117DOI Listing
April 2019
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