3,027 results match your criteria Biomedical optics express[Journal]


Time domain X-ray luminescence computed tomography: numerical simulations.

Biomed Opt Express 2019 Jan 21;10(1):372-383. Epub 2018 Dec 21.

Department of Bioengineering, University of California, Merced, Merced, CA 95343, USA.

X-ray luminescence computed tomography (XLCT) has the potential to image the biodistribution of nanoparticles inside deep tissues. In XLCT, X-ray excitable nanophosphors emit optical photons for tomographic imaging. The lifetime of the nanophosphor signal, rather than its intensity, could be used to extract biological microenvironment information such as oxygenation in deep tumors. Read More

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http://dx.doi.org/10.1364/BOE.10.000372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363188PMC
January 2019

Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA).

Biomed Opt Express 2019 Jan 21;10(1):356-371. Epub 2018 Dec 21.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris and eye diseases. We used several techniques to study choroidal perfusion, including laser Doppler flowmetry, laser speckle flowgraphy, and optical coherence tomography angiography (OCTA), but with the latter no standardized algorithm for quantitative analysis has been provided. Read More

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http://dx.doi.org/10.1364/BOE.10.000356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363185PMC
January 2019

Wide-field whole eye OCT system with demonstration of quantitative retinal curvature estimation.

Biomed Opt Express 2019 Jan 21;10(1):338-355. Epub 2018 Dec 21.

Department of Ophthalmology, Duke University Medical Center, 2351 Erwin Road, Durham, NC 27710, USA.

Current conventional clinical OCT systems image either only the anterior or the posterior eye during a single acquisition. This localized imaging limits conventional OCT's use for characterizing global ocular morphometry and biometry, which requires knowledge of spatial relationships across the entire eye. We developed a "whole eye" optical coherence tomography system that simultaneously acquires volumes with a wide field-of-view for both the anterior chamber (14 x 14 mm) and retina (55°) using a single source and detector. Read More

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http://dx.doi.org/10.1364/BOE.10.000338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363197PMC
January 2019

Methods for registering and calibrating terahertz images of cutaneous burn wounds.

Biomed Opt Express 2019 Jan 21;10(1):322-337. Epub 2018 Dec 21.

Department of Bioengineering, University of Los Angeles, California, 410 Westwood Plaza, Los Angeles, CA 90025, USA.

A method to register THz and visible images of cutaneous burn wounds and to calibrate THz image data is presented. Images of partial and full thickness burn wounds in 9 rats were collected over 435 mins. = 7. Read More

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http://dx.doi.org/10.1364/BOE.10.000322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363189PMC
January 2019

Real-time compensation method for robust polarimetric determination of glucose in turbid media.

Biomed Opt Express 2019 Jan 19;10(1):308-321. Epub 2018 Dec 19.

Lübeck University of Applied Sciences, Medical Sensors and Devices Laboratory, Mönkhofer Weg 239, Lübeck 23562, Germany.

Polarimetric determination of glucose is known to be strongly affected by scattering in turbid media. Other effects like fluctuations of light source emission and sample absorption also deteriorate glucose predictability. This work presents a measurement setup using a real-time data processing method to address these problems. Read More

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http://dx.doi.org/10.1364/BOE.10.000308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363211PMC
January 2019

Short-time series optical coherence tomography angiography and its application to cutaneous microvasculature.

Biomed Opt Express 2019 Jan 19;10(1):293-307. Epub 2018 Dec 19.

Optical+Biomedical Engineering Laboratory, Department of Electrical, Electronic and Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth WA 6009, Australia.

We present a new optical coherence tomography (OCT) angiography method for imaging tissue microvasculature based on the characteristic frequency-domain flow signature in a short time series of a single voxel. The angiography signal is generated by Fourier transforming the OCT signal time series from a given voxel in multiple acquisitions and computing the average magnitude of non-zero (high-pass) frequency components. Larger temporal variations of the OCT signal caused by blood flow result in higher values of the average magnitude in the frequency domain compared to those from static tissue. Read More

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http://dx.doi.org/10.1364/BOE.10.000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363186PMC
January 2019

Digital holographic phase imaging with aberrations totally compensated.

Biomed Opt Express 2019 Jan 19;10(1):283-292. Epub 2018 Dec 19.

College of Life Information Science and Instrument Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.

Digital holography is a well-accepted method for phase imaging. However, the phase of the object is always embedded in aberrations. Here, we present a digital holographic phase imaging with the aberrations fully compensated, including the high order aberrations. Read More

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http://dx.doi.org/10.1364/BOE.10.000283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363187PMC
January 2019

Quasi-simultaneous multiplane calcium imaging of neuronal circuits.

Biomed Opt Express 2019 Jan 19;10(1):267-282. Epub 2018 Dec 19.

Department of Engineering Science, University of Oxford, Parks Road, OX1 3PJ, UK.

Two-photon excitation fluorescence microscopy is widely used to study the activity of neuronal circuits. However, the fast imaging is typically constrained to a single lateral plane for a standard microscope design. Given that cortical neuronal networks in a mouse brain are complex three-dimensional structures organised in six histologically defined layers which extend over many hundreds of micrometres, there is a strong demand for microscope systems that can record neuronal signalling in volumes. Read More

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http://dx.doi.org/10.1364/BOE.10.000267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363184PMC
January 2019

Sensorless adaptive optics multimodal en-face small animal retinal imaging.

Biomed Opt Express 2019 Jan 19;10(1):252-267. Epub 2018 Dec 19.

Engineering Science, Simon Fraser University, Burnaby, BC, Canada.

Vision researchers often use small animals due to the availability of many transgenic strains that model human diseases or express biomarkers. Adaptive optics (AO) enables non-invasive single-cell imaging in a living animal but often results in high system complexity. Sensorless AO (SAO) can provide depth-resolved aberration correction with low system complexity. Read More

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http://dx.doi.org/10.1364/BOE.10.000252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363194PMC
January 2019
3.648 Impact Factor

Phantom study of a fiber optic force sensor design for biopsy needles under MRI.

Biomed Opt Express 2019 Jan 18;10(1):242-251. Epub 2018 Dec 18.

Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.

Biopsy needles with embedded force sensors can eliminate the needle deflection and the needle targeting failure risks during MRI guided biopsy procedures. Fabry-Pérot interferometry (FPI) based sensors are small, compact and immune to electromagnetic and RF interferences, and therefore they are suitable for needle guidance under MRI. In this work, an FPI based fiber optic force sensor design and its integration to an 18-gauge MRI compatible biopsy needle are presented. Read More

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http://dx.doi.org/10.1364/BOE.10.000242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363210PMC
January 2019

Handheld optical palpation of turbid tissue with motion-artifact correction.

Biomed Opt Express 2019 Jan 18;10(1):226-241. Epub 2018 Dec 18.

BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, 6009, Australia.

Handheld imaging probes are needed to extend the clinical translation of optical elastography to applications, yet such probes have received little attention. In this paper, we present the first demonstration of optical palpation using a handheld probe. Optical palpation is a variant of optical elastography that uses three-dimensional optical coherence tomography (3D-OCT) to provide maps of stress at the tissue surface under static compression. Read More

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http://dx.doi.org/10.1364/BOE.10.000226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363209PMC
January 2019

Side-polished flexible SPR sensor modified by graphene with temperature self-compensation.

Biomed Opt Express 2019 Jan 17;10(1):215-225. Epub 2018 Dec 17.

State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, 300072, China.

Fiber-based techniques make it possible to implant a miniaturized and flexible surface plasmon resonance (SPR) sensor into the human body. However, for implantable applications, the miniaturization of fiber SPR sensors results in low sensitivity compared with traditional prism-type SPR sensors due to limited space and the effects of temperature fluctuations. Therefore, it is necessary to compensate for temperature drift in the measurements, such as the case of the quantification of the relationship between glucose concentration and SPR resonance wavelength. Read More

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http://dx.doi.org/10.1364/BOE.10.000215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363195PMC
January 2019

Depth-extended, high-resolution fluorescence microscopy: whole-cell imaging with double-ring phase (DRiP) modulation.

Biomed Opt Express 2019 Jan 14;10(1):204-214. Epub 2018 Dec 14.

Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.

We report a depth-extended, high-resolution fluorescence microscopy system based on interfering Bessel beams generated with double-ring phase (DRiP) modulation. The DRiP method effectively suppresses the Bessel side lobes, exhibiting a high resolution of the main lobe throughout a four- to five-fold improved depth of focus (DOF), compared to conventional wide-field microscopy. We showed both theoretically and experimentally the generation and propagation of a DRiP point-spread function (DRiP-PSF) of the imaging system. Read More

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http://dx.doi.org/10.1364/BOE.10.000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363204PMC
January 2019

Alternations of hemodynamic parameters during Chinese cupping therapy assessed by an embedded near-infrared spectroscopy monitor.

Biomed Opt Express 2019 Jan 12;10(1):196-203. Epub 2018 Dec 12.

Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300000, China.

Cupping therapy is a promising method to cure or reduce the symptoms of some diseases including muscle pain/tendency/fatigue. Although the applications of cupping therapy have a thousand-year history in traditional Chinese medicine, the therapeutic effect of cupping is still questionable due to a lack of scientific evidence and the absence of physiological observations. In our previous study, we utilized near-infrared spectroscopy (NIRS) to assess the concentration change surrounding the cupping site and found a significant elevation in oxy-hemoglobin (HbO). Read More

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http://dx.doi.org/10.1364/BOE.10.000196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363192PMC
January 2019

High-speed dual color fluorescence lifetime endomicroscopy for highly-multiplexed pulmonary diagnostic applications and detection of labeled bacteria.

Biomed Opt Express 2019 Jan 12;10(1):181-195. Epub 2018 Dec 12.

Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.

We present a dual-color laser scanning endomicroscope capable of fluorescence lifetime endomicroscopy at one frame per second (FPS). The scanning system uses a coherent imaging fiber with 30,000 cores. High-speed lifetime imaging is achieved by distributing the signal over an array of 1024 parallel single-photon avalanche diode detectors (SPADs), minimizing detection dead-time maximizing the number of photons detected per excitation pulse without photon pile-up to achieve the high frame rate. Read More

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http://dx.doi.org/10.1364/BOE.10.000181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363193PMC
January 2019

Visualizing the vasculature of the entire human eye posterior hemisphere without a contrast agent.

Biomed Opt Express 2019 Jan 12;10(1):167-180. Epub 2018 Dec 12.

Physical Sciences, Inc., 20 New England Business Center, Andover, MA 01810, USA.

The platform described here combines the non-invasive measurement of the retina/choroid structure and ocular blood flow based on optical coherence tomography (OCT) and wide-field semi-quantitative global flow visualization using line-scanning Doppler flowmetry (LSDF). The combination of these two imaging modalities within the same platform enables comprehensive assessment of blood flow in the retina and choroid in animals and human subjects for diagnostic purposes. Ultra-widefield vasculature visualization is demonstrated here for the first time without injecting additional contrast agents and based only on the motion of particles within the vasculature. Read More

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http://dx.doi.org/10.1364/BOE.10.000167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363207PMC
January 2019

Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy .

Biomed Opt Express 2019 Jan 11;10(1):151-166. Epub 2018 Dec 11.

EyePod Small Animal Ocular Imaging Laboratory, University of California, Davis, CA 95616, USA.

In cancer research there is a fundamental need for animal models that allow the longitudinal visualization and quantification of tumor development, nanotherapeutic delivery, the tumor microenvironment including blood vessels, macrophages, fibroblasts, immune cells, and extracellular matrix, and the tissue response to treatment. To address this need, we developed a novel mouse ocular xenograft model. Green fluorescent protein (GFP) expressing human glioblastoma cells (between 500 and 10,000) were implanted into the subretinal space of immunodeficient mice (56 eyes). Read More

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http://dx.doi.org/10.1364/BOE.10.000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363190PMC
January 2019

Integrated multimodal photoacoustic microscopy with OCT- guided dynamic focusing.

Biomed Opt Express 2019 Jan 11;10(1):137-150. Epub 2018 Dec 11.

Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.

Combining different contrast mechanisms to achieve simultaneous multimodal imaging is always desirable but is challenging due to the various optical and hardware requirements for different imaging systems. We developed a multimodal microscopic optical imaging system with the capability of providing comprehensive structural, functional and molecular information of living tissues. This imaging system integrated photoacoustic microscopy (PAM), optical coherence tomography (OCT), optical Doppler tomography (ODT) and confocal fluorescence microscopy in one platform. Read More

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http://dx.doi.org/10.1364/BOE.10.000137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363202PMC
January 2019

Invariant features-based automated registration and montage for wide-field OCT angiography.

Biomed Opt Express 2019 Jan 11;10(1):120-136. Epub 2018 Dec 11.

Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.

The field of view of optical coherence tomography angiography (OCTA) images of the retina can be increased by montaging consecutive scans acquired at different retinal regions. Given the dramatic variation in aberrations throughout the entire posterior pole region, it is challenging to achieve seamless merging with apparent capillary continuity across the boundaries between adjacent angiograms. For this purpose, we propose herein a method that performs automated registration of contiguous OCTA images based on invariant features and uses a novel montage algorithm. Read More

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http://dx.doi.org/10.1364/BOE.10.000120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363196PMC
January 2019

Erratum: Ciliary muscle thickness profiles derived from optical coherence tomography images: erratum.

Biomed Opt Express 2019 Jan 7;10(1):119. Epub 2018 Dec 7.

Institute for Ophthalmic Research, Eberhard Karls University Tuebingen, Elfriede-Aulhorn-Str. 7, 72076 Tuebingen, Germany.

[This corrects the article on p. 5100 in vol. 9, PMID: 30319924. Read More

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https://www.osapublishing.org/abstract.cfm?URI=boe-10-1-119
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http://dx.doi.org/10.1364/BOE.10.000119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363208PMC
January 2019
1 Read

Biophysical basis of skin cancer margin assessment using Raman spectroscopy.

Biomed Opt Express 2019 Jan 7;10(1):104-118. Epub 2018 Dec 7.

Department of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton Street C0800, Austin, TX 78712, USA.

Achieving adequate margins during tumor margin resection is critical to minimize the recurrence rate and maximize positive patient outcomes during skin cancer surgery. Although Mohs micrographic surgery is by far the most effective method to treat nonmelanoma skin cancer, it can be limited by its inherent required infrastructure, including time-consuming and expensive on-site histopathology. Previous studies have demonstrated that Raman spectroscopy can accurately detect basal cell carcinoma (BCC) from surrounding normal tissue; however, the biophysical basis of the detection remained unclear. Read More

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http://dx.doi.org/10.1364/BOE.10.000104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363200PMC
January 2019

Multiscale x-ray phase-contrast tomography in a mouse model of transient focal cerebral ischemia.

Biomed Opt Express 2019 Jan 5;10(1):92-103. Epub 2018 Dec 5.

Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.

Cerebral ischemia is associated with a lack of oxygen and high-energy phosphates within the brain tissue, leading to irreversible cell injury. Visualizing these cellular injuries has long been a focus of experimental stroke research with application of immunohistochemistry as one of the standard approaches. It is, however, a destructive imaging technique with non-isotropic resolution, as only the two-dimensional tissue structure of a thin brain section is visualized using optical microscopy and specific stainings. Read More

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http://dx.doi.org/10.1364/BOE.10.000092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363203PMC
January 2019

Non-intrusive studies of gas contents and gas diffusion in hen eggs.

Biomed Opt Express 2019 Jan 5;10(1):83-91. Epub 2018 Dec 5.

Center of Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, University City Campus, Guangzhou 510006, China.

A detailed study of the condition of eggs was performed using tunable diode lasers to monitor free gas in hen eggs. We detected oxygen and water vapor signals from 13 unfertilized eggs and studied the growth of the egg air cell over a time period of 3 weeks. We also studied the gas exchange through the egg shell, which is of particular interest for fertilized eggs. Read More

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http://dx.doi.org/10.1364/BOE.10.000083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363199PMC
January 2019

Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye.

Biomed Opt Express 2019 Jan 5;10(1):66-82. Epub 2018 Dec 5.

Center for Visual Science, University of Rochester, Rochester, NY, USA.

Progress is needed in developing animal models of photoreceptor degeneration and evaluating such models with longitudinal, noninvasive techniques. We employ confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT) and high-resolution retinal imaging to noninvasively observe the retina of non-human primates with induced photoreceptor degeneration. Photoreceptors were imaged at the single-cell scale in three modalities of adaptive optics scanning light ophthalmoscopy: traditional confocal reflectance, indicative of waveguiding; a non-confocal offset aperture technique visualizing scattered light; and two-photon excited fluorescence, the time-varying signal of which, at 730 nm excitation, is representative of visual cycle function. Read More

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http://dx.doi.org/10.1364/BOE.10.000066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363191PMC
January 2019

Megahertz-rate optical coherence tomography angiography improves the contrast of the choriocapillaris and choroid in human retinal imaging.

Biomed Opt Express 2019 Jan 5;10(1):50-65. Epub 2018 Dec 5.

Vison Science and Advanced Retinal Imaging Laboratory, Department of Ophthalmology & Vision Science, University of California Davis, Sacramento, CA 95817, USA.

Angiographic imaging of the human eye with optical coherence tomography (OCT) is becoming an increasingly important tool in the scientific investigation and clinical management of several blinding diseases, including age-related macular degeneration and diabetic retinopathy. We have observed that OCT angiography (OCTA) of the human choriocapillaris and choroid with a 1.64 MHz A-scan rate swept-source laser yields higher contrast images as compared to a slower rate system operating at 100 kHz. Read More

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http://dx.doi.org/10.1364/BOE.10.000050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363198PMC
January 2019

Fast, volumetric live-cell imaging using high-resolution light-field microscopy.

Biomed Opt Express 2019 Jan 4;10(1):29-49. Epub 2018 Dec 4.

Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.

Visualizing diverse anatomical and functional traits that span many spatial scales with high spatio-temporal resolution provides insights into the fundamentals of living organisms. Light-field microscopy (LFM) has recently emerged as a scanning-free, scalable method that allows for high-speed, volumetric functional brain imaging. Given those promising applications at the tissue level, at its other extreme, this highly-scalable approach holds great potential for observing structures and dynamics in single-cell specimens. Read More

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http://dx.doi.org/10.1364/BOE.10.000029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363205PMC
January 2019

Polarization induced contrast X-ray fluorescence at submicrometer resolution reveals nanometer apatite crystal orientations across entire tooth sections.

Biomed Opt Express 2019 Jan 3;10(1):18-28. Epub 2018 Dec 3.

Department for Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, Aßmannshauser Str. 4-6 Berlin 14197, Germany.

For biomedical research, successful imaging of calcified microstructures often relies on absorption differences between features, or on employing dies with selective affinity to areas of interest. When texture is concerned, e.g. Read More

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http://dx.doi.org/10.1364/BOE.10.000018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363201PMC
January 2019

Regularized reconstruction based on joint L and total variation for sparse-view cone-beam X-ray luminescence computed tomography.

Biomed Opt Express 2019 Jan 3;10(1):1-17. Epub 2018 Dec 3.

Department of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

As an emerging hybrid imaging modality, cone-beam X-ray luminescence computed tomography (CB-XLCT) has been proposed based on the development of X-ray excitable nanoparticles. Owing to the high degree of absorption and scattering of light through tissues, the CB-XLCT inverse problem is inherently ill-conditioned. Appropriate priors or regularizations are needed to facilitate reconstruction and to restrict the search space to a specific solution set. Read More

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http://dx.doi.org/10.1364/BOE.10.000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363206PMC
January 2019

Comparison of source localization techniques in diffuse optical tomography for fNIRS application using a realistic head model.

Biomed Opt Express 2018 Jul 7;9(7):2994-3016. Epub 2018 Jun 7.

LIONLAB, Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montréal, Canada.

Functional near-infrared spectroscopy (fNIRS) is a non-invasive imaging technique that elicits growing interest for research and clinical applications. In the last decade, efforts have been made to develop a mathematical framework in order to image the effective sources of hemoglobin variations in brain tissues. Different approaches can be used to impose additional information or constraints when reconstructing the cerebral images of an ill-posed problem. Read More

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http://dx.doi.org/10.1364/BOE.9.002994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033567PMC
July 2018
2 Reads

Label-free real-time ultrasensitive monitoring of non-small cell lung cancer cell interaction with drugs.

Biomed Opt Express 2018 Sep 7;9(9):4149-4161. Epub 2018 Aug 7.

The State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems, school of Physics and Astronomy, Shanghai JiaoTong University, Shanghai 200240, China.

The timely discovery of cancer cell resistance in clinical processing and the accurate calculation of drug dosage to reduce and inhibit tumour growth factor in cancer patients are promising technologies in cancer therapy. Here, an optofluidic resonator effectively detects drug interactions with cancer cell processing in real time and enables the calculation of label-free drug-non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) and binding ratios using molecular fluorescence intensity. According to clinical test and in vivo experimental data, the efficiencies of gefitinib and erlotinib are only 37% and 12% compared to AZD9291, and 0. Read More

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http://dx.doi.org/10.1364/BOE.9.004149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157792PMC
September 2018
2 Reads

Label-free assessment of carotid artery biochemical composition using fiber-based fluorescence lifetime imaging.

Biomed Opt Express 2018 Sep 6;9(9):4064-4076. Epub 2018 Aug 6.

Department of Biomedical Engineering, University of California, Davis, 451 E. Health Sciences Dr., Davis, CA 95616, USA.

Novel diagnostic tools with the ability to monitor variations in biochemical composition and provide benchmark indicators of vascular tissue maturation are needed to create functional tissue replacements. We investigated the ability of fiber-based, label-free multispectral fluorescent lifetime imaging (FLIm) to quantify the anatomical variations in biochemical composition of native carotid arteries and validated these results against biochemical assays. FLIm-derived parameters in spectral band 415-455 nm correlated with tissue collagen content () and cell number () and in spectral band 465-553 nm strongly correlated with elastin content (). Read More

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http://dx.doi.org/10.1364/BOE.9.004064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157793PMC
September 2018
1 Read

Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography.

Biomed Opt Express 2018 Sep 24;9(9):4429-4442. Epub 2018 Aug 24.

Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Advances in the retinal layer segmentation of structural optical coherence tomography (OCT) images have allowed the separation of capillary plexuses in OCT angiography (OCTA). With the increased scanning speeds of OCT devices and wider field images (≥10 mm on fast-axis), greater retinal curvature and anatomic variations have introduced new challenges. In this study, we developed a novel automated method to segment seven retinal layer boundaries and two retinal plexuses in wide-field OCTA images. Read More

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http://dx.doi.org/10.1364/BOE.9.004429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157796PMC
September 2018
1 Read

Analysis and classification of kidney stones based on Raman spectroscopy.

Biomed Opt Express 2018 Sep 9;9(9):4175-4183. Epub 2018 Aug 9.

Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang 110167, China.

The number of patients with kidney stones worldwide is increasing, and it is particularly important to facilitate accurate diagnosis methods. Accurate analysis of the type of kidney stones plays a crucial role in the patient's follow-up treatment. This study used microscopic Raman spectroscopy to analyze and classify the different mineral components present in kidney stones. Read More

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http://dx.doi.org/10.1364/BOE.9.004175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157795PMC
September 2018
2 Reads

Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study.

Biomed Opt Express 2018 Sep 29;9(9):4539-4551. Epub 2018 Aug 29.

College of Transdisciplinary Studies, Daegu Gyeongbuk Institute of Science and Technology, 333 Techno Jungang-daero, Hyeonpung-myeon, Dalseong-gun, Daegu, South Korea.

We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. Read More

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http://dx.doi.org/10.1364/BOE.9.004539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157794PMC
September 2018
3 Reads

classification of spinal cord tumors using autofluorescence spectroscopy and immunohistochemical indexes.

Biomed Opt Express 2018 Sep 21;9(9):4401-4412. Epub 2018 Aug 21.

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.

Spinal cord tumors are complicated and infrequent, which poses a major challenge to surgeons during neurosurgery. Currently, the intraoperative identification of the tissues' pathological properties is usually difficult for surgeons. This issue influences the decision-making in treatment planning. Read More

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http://dx.doi.org/10.1364/BOE.9.004401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157786PMC
September 2018
1 Read

Quantified elasticity mapping of retinal layers using synchronized acoustic radiation force optical coherence elastography.

Biomed Opt Express 2018 Sep 2;9(9):4054-4063. Epub 2018 Aug 2.

Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA.

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly (over the age of 60 years) in western countries. In the early stages of the disease, structural changes may be subtle and cannot be detected. Recently it has been postulated that the mechanical properties of the retina may change with the onset of AMD. Read More

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http://dx.doi.org/10.1364/BOE.9.004054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157789PMC
September 2018
1 Read
3.648 Impact Factor

Erratum: Visualization of laser tattoo removal treatment effects in a mouse model by two-photon microscopy: publisher's note.

Biomed Opt Express 2018 Sep 8;9(9):4162. Epub 2018 Aug 8.

Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, San 31, Hyoja-dong, Nam-gu, Pohang, Gyeongbuk 790-784, South Korea.

[This corrects the article on p. 3735 in vol. 8, PMID: 28856046. Read More

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http://dx.doi.org/10.1364/BOE.9.004162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157788PMC
September 2018
5 Reads

Label-free and stable serum analysis based on Ag-NPs/PSi surface-enhanced Raman scattering for noninvasive lung cancer detection.

Biomed Opt Express 2018 Sep 17;9(9):4345-4358. Epub 2018 Aug 17.

Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, School of Physics and Electronics, Shandong Normal University, Jinan 250014, China.

Surface-enhanced Raman scattering (SERS) has a broad application prospect in the field of tumor detection owing to its ultrahigh detective sensitivity. However, SERS analysis of serum remain a challenge in terms of repeatability and stability due to the maldistribution of the silver nanoparticles (Ag-NPs)-serum. With the aim to make up for this shortcoming, we report a new method for obtaining stable serum Raman signals utilizing the ordered arrays of pyramidal silicon (PSi) and Ag-NPs. Read More

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https://www.osapublishing.org/abstract.cfm?URI=boe-9-9-4345
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http://dx.doi.org/10.1364/BOE.9.004345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157787PMC
September 2018
3 Reads
3.648 Impact Factor

Laser-activated perfluorocarbon nanodroplets: a new tool for blood brain barrier opening.

Biomed Opt Express 2018 Sep 29;9(9):4527-4538. Epub 2018 Aug 29.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA.

A major obstacle in the monitoring and treatment of neurological diseases is the blood brain barrier (BBB), a semipermeable barrier that prevents the delivery of many therapeutics and imaging contrast agents to the brain. In this work, we explored the possibility of laser-activated perfluorocarbon nanodroplets (PFCnDs) to open the BBB and deliver agents to the brain tissue. Specifically, near infrared (NIR) dye-loaded PFCnDs comprised of a perfluorocarbon (PFC) core with a boiling point above physiological temperature were repeatedly vaporized and recondensed from liquid droplet to gas bubble under pulsed laser excitation. Read More

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https://www.osapublishing.org/abstract.cfm?URI=boe-9-9-4527
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http://dx.doi.org/10.1364/BOE.9.004527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157760PMC
September 2018
8 Reads

Phase retrieval for arbitrary Fresnel-like linear shift-invariant imaging systems suitable for tomography.

Biomed Opt Express 2018 Sep 21;9(9):4390-4400. Epub 2018 Aug 21.

European XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.

We present a generalization of the non-iterative phase retrieval in X-ray phase contrast imaging applicable for an arbitrary linear shift-invariant (LSI) imaging system with a non-negligible amount of free space propagation (termed as Fresnel-like). Our novel approach poses no restrictions on the propagation distance between optical elements of the system. In turn, the requirements are only demanded for the transfer function of the optical elements, which should be approximable by second-order Taylor polynomials. Read More

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http://dx.doi.org/10.1364/BOE.9.004390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157775PMC
September 2018
2 Reads

Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study.

Biomed Opt Express 2018 Sep 14;9(9):4196-4216. Epub 2018 Aug 14.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.

Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. Read More

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http://dx.doi.org/10.1364/BOE.9.004196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157785PMC
September 2018
3 Reads

Modified wavelength scanning interferometry for simultaneous tomography and topography of the cornea with Fourier domain optical coherence tomography.

Biomed Opt Express 2018 Sep 27;9(9):4443-4458. Epub 2018 Aug 27.

Department of Biomedical Engineering, University of Houston, Houston, TX 77004, USA.

Visual acuity is dependent on corneal shape and size. A minor variation in surface geometry can cause a deformation of corneal geometry, which affects its optical performance. In this work we demonstrate an algorithm for the simultaneous measurement of corneal tomography and topography with a traditional point-scanning Fourier domain optical coherence tomography (FD-OCT) system. Read More

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http://dx.doi.org/10.1364/BOE.9.004443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157774PMC
September 2018
1 Read

Detection of lithium in breast milk and in situ elemental analysis of the mammary gland.

Biomed Opt Express 2018 Sep 13;9(9):4184-4195. Epub 2018 Aug 13.

Department of Physics, City University of Hong Kong, Hong Kong SAR, China.

Breast feeding provides considerable benefits to the infant and mother. However, a lithium-based psychiatric medication may cause side effects in the child. Using laser induced breakdown spectroscopy (LIBS), trace lithium levels were observed in the breast milk of lactating rats administered with lithium treatment postpartum. Read More

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http://dx.doi.org/10.1364/BOE.9.004184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157784PMC
September 2018
1 Read

Enhancing sparse-view photoacoustic tomography with combined virtually parallel projecting and spatially adaptive filtering.

Biomed Opt Express 2018 Sep 31;9(9):4569-4587. Epub 2018 Aug 31.

College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.

To fully realize the potential of photoacoustic tomography (PAT) in preclinical and clinical applications, rapid measurements and robust reconstructions are needed. Sparse-view measurements have been adopted effectively to accelerate the data acquisition. However, since the reconstruction from the sparse-view sampling data is challenging, both the effective measurement and the appropriate reconstruction should be taken into account. Read More

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http://dx.doi.org/10.1364/BOE.9.004569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157779PMC
September 2018
1 Read

Ultrasound-assisted photothermal therapy and real-time treatment monitoring.

Biomed Opt Express 2018 Sep 27;9(9):4472-4480. Epub 2018 Aug 27.

Department of Biomedical Engineering, Sogang University, Seoul, 04107, South Korea.

Photothermal therapy (PTT) has the capability for selective treatment, in which light delivered to the target is converted into heat and subsequently causes coagulative necrosis. However, optical scattering in biological media limits light penetration, thus reducing therapeutic efficacy. Here, we demonstrate that the temperatures generated by light and ultrasound energies can be added constructively in resected melanoma cancers, which causes an increase in treatment depth. Read More

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https://www.osapublishing.org/abstract.cfm?URI=boe-9-9-4472
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http://dx.doi.org/10.1364/BOE.9.004472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157783PMC
September 2018
10 Reads
3.648 Impact Factor

Rapid and in situ optical detection of trace lithium in tissues.

Biomed Opt Express 2018 Sep 27;9(9):4459-4471. Epub 2018 Aug 27.

Department of Physics, City University of Hong Kong, Hong Kong SAR, China.

Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer's disease. However, the therapeutic mechanisms are not well characterized due to limitations in detecting lithium in organs and cells. This limits the ability to improve lithium-based treatments. Read More

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http://dx.doi.org/10.1364/BOE.9.004459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157780PMC
September 2018
3 Reads

Upconverting nanoparticle micro-lightbulbs designed for deep tissue optical stimulation and imaging.

Biomed Opt Express 2018 Sep 20;9(9):4359-4371. Epub 2018 Aug 20.

Department of Electrical Engineering and Computer Sciences, University of California Berkeley, Berkeley, CA 94720, USA.

Optical methods for imaging and stimulation of biological events based on the use of visible light are limited to the superficial layers of tissue due to the significant absorption and scattering of light. Here, we demonstrate the design and implementation of passive micro-structured lightbulbs (MLBs) containing bright-emitting lanthanide-doped upconverting nanoparticles (UCNPs) for light delivery deep into the tissue. The MLBs are realized as cylindrical pillars made of Parylene C polymer that can be implanted deep into the tissue. Read More

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https://www.osapublishing.org/abstract.cfm?URI=boe-9-9-4359
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http://dx.doi.org/10.1364/BOE.9.004359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157781PMC
September 2018
5 Reads

Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue.

Biomed Opt Express 2018 Sep 14;9(9):4217-4234. Epub 2018 Aug 14.

Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

Cherenkov-excited luminescence scanned imaging (CELSI) is achieved with external beam radiotherapy to map out molecular luminescence intensity or lifetime in tissue. Just as in fluorescence microscopy, the choice of excitation geometry can affect the imaging time, spatial resolution and contrast recovered. In this study, the use of spatially patterned illumination was systematically studied comparing scan shapes, starting with line scan and block patterns and increasing from single beams to multiple parallel beams and then to clinically used treatment plans for radiation therapy. Read More

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http://dx.doi.org/10.1364/BOE.9.004217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157777PMC
September 2018
3 Reads

Terahertz irradiation-induced motility enhancement and intracellular calcium elevation in human sperm in vitro.

Biomed Opt Express 2018 Sep 2;9(9):3998-4008. Epub 2018 Aug 2.

Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou, Wuhan, Hubei 430030, China.

To date, there has been limited evidence to reveal the effect of terahertz radiation on sperm. In this study, semen samples were collected from males who had just finished a prepregnancy computer-assisted semen analysis (CASA). The motility, intracellular concentration of free Ca and DNA integrity of sperm with or without terahertz (0. Read More

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https://www.osapublishing.org/abstract.cfm?URI=boe-9-9-3998
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http://dx.doi.org/10.1364/BOE.9.003998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157776PMC
September 2018
5 Reads

Compact, modular and in-plane AOSLO for high-resolution retinal imaging.

Biomed Opt Express 2018 Sep 15;9(9):4275-4293. Epub 2018 Aug 15.

Department of Experimental Psychology, University of Oxford, 15 Parks Road, Oxford OX1 3PH, UK.

The adaptive optics scanning laser ophthalmoscope (AOSLO) was first developed in 2002 and since then the technology has been adopted in several laboratories around the world, for both clinical and psychophysical research. There have been a few major design implementations of the AOSLO. The first used on-axis tilted spherical mirrors in a planar arrangement, and the second minimized the build up of astigmatism present in the first design by using a non-planar arrangement. Read More

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http://dx.doi.org/10.1364/BOE.9.004275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157778PMC
September 2018
1 Read