573,610 results match your criteria Biomedical materials Bristol England[Journal]


Cardiovascular Benefits of a Diet Enriched in Fruits and Vegetables.

Am J Nephrol 2019 Apr 17;49(6):435-437. Epub 2019 Apr 17.

Distinguished Scientist-in-Residence, Department of Health Studies, College of Arts and Sciences, American University, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1159/000500044DOI Listing

The Mealtime Assessment Scale (MAS): Part 2 - Preliminary Psychometric Analysis.

Folia Phoniatr Logop 2019 Apr 17:1-12. Epub 2019 Apr 17.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: The Mealtime Assessment Scale (MAS) was developed to assess swallowing safety and efficacy during the meal. The study aims to perform a preliminary validation of MAS by investigating internal consistency, inter-rater agreement, concurrent and known-group validity, and responsiveness.

Methods: MAS was tested on 100 persons without dysphagia (group 1) and 100 persons with dysphagia (group 2). Read More

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http://dx.doi.org/10.1159/000494136DOI Listing

Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, UNITED STATES.

Most solid tumors are characterized by highly dense, isotropic vessel networks. Characterization of such features has shown promise for early cancer diagnosis. Ultrasound diffusion has been used to characterize the micro-architecture of complex media, such as bone and the lungs. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1a44
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http://dx.doi.org/10.1088/1361-6560/ab1a44DOI Listing
April 2019
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ADAM phantom to test 4D medical imaging and dose delivery devices.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Agricultural, Food and Forestry System, Universita di Firenze, Florence, ITALY.

Radiotherapy treatment of moving lesions is a challenging task in which different strategies can be used. The clinical implementation of the variety of complex technical solutions pursued to treat cancer, while sparing healthy tissues, requires accurate quality assurance tests and adequate phantoms. The aim of this work is to report on the Anthropomorphic Dynamic breAthing Model (ADAM) and on its applications to test image quality and dose delivery for four-dimensional (4D) techniques used to compensate for breathing-induced tumor motion. Read More

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http://iopscience.iop.org/article/10.1088/1361-6560/ab1a49
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http://dx.doi.org/10.1088/1361-6560/ab1a49DOI Listing
April 2019
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Woody's last dance.

Authors:
Andrea Manca

CMAJ 2018 Jul;190(29):E889

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1503/cmaj.180356DOI Listing

Recognition of silver cations by multifarene[2,2] chemosensors with unexpected fluorescence response.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 9;218:213-220. Epub 2019 Apr 9.

Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, China. Electronic address:

Fluorescent chemosensors based on a new macrocyclic compound, multifarene[2,2], with modification by triazole-linked pyrene or anthracene were synthesized. These macrocyclic sensors exhibited high affinity and selectivity toward Ag over other metal ions, with ratiometric or enhanced response of their fluorescence emissions depending upon the substituent species for coordination to Ag, and an unexpected response to a concentration threshold of the metal cations was discovered. The experimental evidences of fluorescence spectra, H NMR titration, IR spectra, and high-resolution mass spectra suggested the coordination behaviors of the sensors with Ag, that is, the 1:1 complexes were formed with moderate association constants of about 10 L·mol, and the sulfur atoms on macrocyclic ligand should affinite to the metal cations. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.011DOI Listing

Non-invasive Multi-modal Methods to Differentiate Inflamed vs Fibrotic Strictures in Patients With Crohn's Disease.

Clin Gastroenterol Hepatol 2019 Apr 14. Epub 2019 Apr 14.

IBD Centre, Humanitas Clinical and Research Centre, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy. Electronic address:

Fibrotic strictures occur in 30% of patients with Crohn's disease (CD). However, there are no therapeutic agents that prevent or reverse fibrotic strictures. Strictures are treated by endoscopic dilatation procedures and surgical procedures, but there are high rates of recurrence. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.025DOI Listing

Determinants of structural segregation and patterning in the human cortex.

Neuroimage 2019 Apr 14. Epub 2019 Apr 14.

Department of Anatomy & Neurobiology, University of California, Irvine, USA.

This study aimed at uncovering mechanisms that govern the spatio-temporal patterning of the human cortex and its structural variability, and drawing links between fetal brain development and variability in adult brains. A data-driven analytic approach based on structural MR images revealed the following findings: (1) The cortical surface can be subdivided into 13 independent regions ("communities") based on macroscopic features. (2) Thirty centers of low inter-subject variability were found in major sulci on the cortical surface. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193031
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http://dx.doi.org/10.1016/j.neuroimage.2019.04.031DOI Listing
April 2019
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Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ aggregation.

Food Chem Toxicol 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50 - 50134, Florence, Italy; Interuniversity Center for the Study of Neurodegenerative Diseases (CIMN), Florence, Italy. Electronic address:

Oleuropein aglycone (OleA), the most abundant polyphenol in extra virgin olive oil (EVOO), and Hydroxythyrosol (HT), the OleA main metabolite, have attracted our interest due to their multitarget effects, including the interference with amyloid aggregation path. However, the mechanistic details of their anti-amyloid effect are not known yet. We report here a broad biophysical approach and cell biology techniques that enabled us to characterize the different molecular mechanisms by which OleA and HT modulate the Aβ fibrillation, a main histopathological feature of Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.015DOI Listing

GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

Immunity 2019 Apr;50(4):796-811

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address:

The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation, and IL-3 and IL-5 may also have such properties. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.022DOI Listing

The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression.

Cell Rep 2019 Apr;27(3):776-792.e7

Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA. Electronic address:

Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and host proteins required for viral replication are typically spared in this process, but the mechanisms of target selectivity during host shutoff remain poorly understood. Using transcriptome-wide and targeted reporter experiments, we demonstrate that the influenza A virus endoribonuclease PA-X usurps RNA splicing to selectively target host RNAs for destruction. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.063DOI Listing

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism.

Cell Rep 2019 Apr;27(3):750-761.e7

Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, SP 13083-862, Brazil. Electronic address:

Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features of C. difficile-induced colitis. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.054DOI Listing

Induction of EGFP expression in Pichia pastoris during co-culture with human endothelial cell line.

J Microbiol Methods 2019 Apr 14. Epub 2019 Apr 14.

Department of Biomedical Sciences, Arthur A. Dugoni School of Dentistry, University of the Pacific, 155 Fifth Street, San Francisco, CA 94103.

While Pichia pastoris has been developed into a versatile recombinant protein expression system, there are only few studies that have investigated the efficacious use of this yeast with human cells. In this study, we demonstrated that P. pastoris can be cultured under mammalian cell culture conditions and co-cultured with human endothelial cells. Read More

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http://dx.doi.org/10.1016/j.mimet.2019.04.006DOI Listing

Postampullectomy Syndrome: Old Mechanism, New Location.

Gastrointest Endosc 2019 Apr 14. Epub 2019 Apr 14.

Professor of Medicine, Division of Digestive Diseases, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1016/j.gie.2019.04.212DOI Listing

Scorpion venom increases acetylcholine release by prolonging the duration of somatic nerve action potentials.

Neuropharmacology 2019 Apr 14. Epub 2019 Apr 14.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Robertson Trust Wing Building, Room 601, 161 Cathedral Street, G4 0RE, Glasgow, UK. Electronic address:

Scorpionism is frequently accompanied by a massive release of catecholamines and acetylcholine from peripheral nerves caused by neurotoxic peptides present in these venoms, which have high specificity and affinity for ion channels. Tityus bahiensis (T. bahiensis) is the second most medically important scorpion species in Brazil but, despite this, its venom remains scarcely studied, especially with regard to its pharmacology on peripheral (somatic and autonomic) nervous system. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.013DOI Listing

Fractional turnover of apolipoprotein(a) and apolipoprotein B-100 within plasma lipoprotein(a) particles in statin-treated patients with elevated and normal Lp(a) concentration.

Metabolism 2019 Apr 14. Epub 2019 Apr 14.

School of Medicine, University of Western Australia, Perth, Australia; Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Australia. Electronic address:

Context: Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein characterized by apolipoprotein(a) [apo(a)] covalently bounded to apoB-100 (apoB). However, the metabolism of apo(a) and apoB within plasma Lp(a) particles in patients on statins remains unclear.

Methods: The kinetics of Lp(a)-apo(a) and Lp(a)-apoB were determined in 20 patients with elevated Lp(a) (≥0. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.010DOI Listing

Serological and molecular evidence of Bartonella henselae in cats from Luanda city, Angola.

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Oporto, Portugal; EpiUnit, Epidemiology Research Unit, Institute of Public Health of the University of Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Oporto, Portugal. Electronic address:

A total of 100 domestic cats from Luanda (Angola) were tested for the presence of antibodies against Bartonella henselae and spotted fever group of Rickettsia (SFGR) using indirect immunofluorescence assay (IFA). Molecular screening targeting the riboflavin synthase (ribC) gene for Bartonella and outer membrane protein B (ompB) gene for Rickettsia, using conventional PCR and sequencing was also performed in cat´s blood samples. Sixty-six percent of the cats from Luanda had IgG antibodies against Bartonella species but none of them had antibodies against SFGR. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.012DOI Listing

Restoring retinal neurovascular health via substance P.

Exp Cell Res 2019 Apr 14. Epub 2019 Apr 14.

Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol, UK; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London Institute of Ophthalmology, London, UK. Electronic address:

Regulation of vascular permeability plays a major role in the pathophysiology of visually threatening conditions such as retinal vein occlusion and diabetic retinopathy. Principally, several factors such as vascular endothelial growth factor (VEGF), are up-regulated or induced in response to hypoxia thus adversely affecting the blood-retinal barrier (BRB), resulting in retinal edema and neovascularisation. Furthermore, current evidence supports a dysregulation of the inner retinal neural-vascular integrity as a critical factor driving retinal ganglion cell (RGC) death and visual loss. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144827193015
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http://dx.doi.org/10.1016/j.yexcr.2019.04.008DOI Listing
April 2019
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One-Pot Synthesis of Poly(glycerol-co-succinic acid) Nanogels for Dermal Delivery.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Polyglycerol nanogels are three-dimensional polymeric networks with a few hundred nanometer sizes and ability to encapsulate and deliver cargos for a wide range of biomedical applications. However, time-consuming and multi-step synthetic routes as well as milligram-scale production have hindered further development of these nanomaterials. In this work, we report on a straightforward synthetic method for the production of polyglycerol nanoarchitectures. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01741DOI Listing

Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

N Engl J Med 2019 Apr;380(16):1535-1545

From United Biomedical, Hauppauge, NY (C.-Y.W., B.-S.K., C.L.F., F.W.-S.); United Biomedical Asia (C.-Y.W., S.L.) and United BioPharma (C.-Y.W., B.-S.K., H.-W.S., C.-Y.L., F.-C.T., A.L., F.-H.Y., C.-H.L., W.T., M.-J.L.), Hsinchu, Taipei Veterans General Hospital, Taipei (W.-W.W., H.-Y.L.), and Kaohsiung Veterans General Hospital (H.-C.T.) and Kaohsiung Medical University Hospital (Y.-H.C.), Kaohsiung - all in Taiwan; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (J.B., K.E.C., T.-W.C.); and the California Department of Public Health, Richmond (C.V.H.).

Background: Administration of a single broadly neutralizing human immunodeficiency virus (HIV)-specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.

Methods: We conducted a nonrandomized, open-label, phase 2 clinical study evaluating the safety, pharmacokinetics, and antiviral activity of UB-421 monotherapy in HIV-infected persons undergoing analytic treatment interruption. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1802264
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http://dx.doi.org/10.1056/NEJMoa1802264DOI Listing
April 2019
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Potential Technologies Review - A hybrid information retrieval framework to accelerate demand-pull innovation in biomedical engineering.

Res Synth Methods 2019 Apr 17. Epub 2019 Apr 17.

Science Management, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.

Launching biomedical innovations based on clinical demands instead of translating basic research findings to practice reduces the risk that the results will not fit the clinical routine. To realize this type of innovation, a meta-analysis of the body of research is necessary to reveal demand-matching concepts. However, both the data deluge and the narrow time constraints for innovation make it impossible to perform such reviews manually. Read More

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http://dx.doi.org/10.1002/jrsm.1350DOI Listing

Metabolic Fingerprinting of Chorionic Villous Samples in Normal Pregnancy and Chromosomal Disorders.

Prenat Diagn 2019 Apr 17. Epub 2019 Apr 17.

Department of Prenatal and Preimplantation Genetic Diagnosis and Fetal Therapy, Ospedale Pediatrico Microcitemico A.Cao, Cagliari, Italy.

Objective: Placenta-related biological samples are used in biomedical research to investigate placental development. Metabolomics represents a promising approach for studying placental metabolism in an effort to explain physiological and pathological mechanisms. The aim of this study was to investigate metabolic changes in chorionic villi during the first trimester of pregnancy in euploid and aneuploid cases. Read More

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http://dx.doi.org/10.1002/pd.5461DOI Listing

Effects of Colombian oregano essential oil (Lippia origanoides Kunth) and Eimeria species on broiler production and cecal microbiota.

Poult Sci 2019 Apr 17. Epub 2019 Apr 17.

Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Bogotá 11001, Colombia.

The gut microbiota has an important effect on poultry health and production. The aim of this study was to evaluate the effect of Colombian oregano (COO), Lippia origanoides Kunth, essential oil supplementation on broiler chicken performance and their cecal bacterial microbiome by 16S-based sequencing. Essential oil was extracted by steam distillation and analyzed by Gas chromatography/mass spectrometry. Read More

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http://dx.doi.org/10.3382/ps/pez193DOI Listing

Maternal Cell Phone Use During Pregnancy, Pregnancy Duration And Fetal Growth In Four Birth Cohorts.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.

Previous studies evaluating potential effects of prenatal exposure to radiofrequency fields from cell phones on birth outcomes are inconsistent. We explored if maternal cell phone use was associated with pregnancy duration and fetal growth. We used information from 55,507 pregnant women and their children from Denmark (1996-2002), the Netherlands (2003-2004), Spain (2003-2008) and Korea (2006-2011). Read More

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http://dx.doi.org/10.1093/aje/kwz092DOI Listing

Large cortical bone pores in the tibia are associated with proximal femur strength.

PLoS One 2019 17;14(4):e0215405. Epub 2019 Apr 17.

Berlin-Brandenburg Center for Regenerative Therapies, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Alterations of structure and density of cortical bone are associated with fragility fractures and can be assessed in vivo in humans at the tibia. Bone remodeling deficits in aging women have been recently linked to an increase in size of cortical pores. In this ex vivo study, we characterized the cortical microarchitecture of 19 tibiae from human donors (aged 69 to 94 years) to address, whether this can reflect impairments of the mechanical competence of the proximal femur, i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215405PLOS

Interactive biomedical ontology matching.

PLoS One 2019 17;14(4):e0215147. Epub 2019 Apr 17.

College of Information Science and Engineering, Fujian University of Technology, Fuzhou, Fujian, China.

Due to continuous evolution of biomedical data, biomedical ontologies are becoming larger and more complex, which leads to the existence of many overlapping information. To support semantic inter-operability between ontology-based biomedical systems, it is necessary to identify the correspondences between these information, which is commonly known as biomedical ontology matching. However, it is a challenge to match biomedical ontologies, which dues to: (1) biomedical ontologies often possess tens of thousands of entities, (2) biomedical terminologies are complex and ambiguous. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215147PLOS

Fluorescent nucleic acid probe in droplets for bacterial sorting (FNAP-sort) as a high-throughput screening method for environmental bacteria with various growth rates.

PLoS One 2019 17;14(4):e0214533. Epub 2019 Apr 17.

Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan.

We have developed a new method for selectively sorting droplets containing growing bacteria using a fluorescence resonance energy transfer (FRET)-based RNA probe. Bacteria and the FRET-based RNA probe are encapsulated into nanoliter-scale droplets, which are incubated to allow for cell growth. The FRET-based RNA probe is cleaved by RNase derived from the bacteria propagated in the droplets, resulting in an increase in fluorescence intensity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214533PLOS

Selective colony area method for heterogeneous patient-derived tumor cell lines in anti-cancer drug screening system.

PLoS One 2019 17;14(4):e0215080. Epub 2019 Apr 17.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

We aimed to establish a fluorescence intensity-based colony area sweeping method by selecting the area of highest viability among patient-derived cancer cells (PDC) which has high tumor heterogeneity. Five gastric cancer cell lines and PDCs were screened with 24 small molecule compounds using a 3D micropillar/microwell chip. 100 tumor cells per well were immobilized in alginate, treated with the compounds, and then stained and scanned for viable cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215080PLOS
April 2019
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Assessing the causes of under-five mortality and proportion associated with pneumococcal diseases in Cameroon. A case-finding retrospective observational study: 2006-2012.

PLoS One 2019 17;14(4):e0212939. Epub 2019 Apr 17.

Mother & Child Centre (MCH), Chantal Biya Foundation, Yaoundé, Cameroon.

Background: Vital registration data outlining causes of deaths (CoD) are important for a sustainable health system, targeted interventions and other relevant policies. There is data paucity on vital registration systems in developing countries. We assessed the leading causes and proportions of under-five deaths, and particularly those related to pneumococcal infections in Yaoundé, Cameroon, using hospital registration data. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212939PLOS

Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission.

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007343. Epub 2019 Apr 17.

Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities; St. Paul, MN, United States of America.

Congenital Zika virus (ZIKV) infection was first linked to birth defects during the American outbreak in 2015/2016. It has been proposed that mutations unique to the Asian/American-genotype explain, at least in part, the ability of Asian/American ZIKV to cause congenital Zika syndrome (CZS). Recent studies identified mutations in ZIKV infecting humans that arose coincident with the outbreak in French Polynesia and were stably maintained during subsequent spread to the Americas. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007343DOI Listing

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice.

PLoS Genet 2019 Apr 17;15(4):e1008069. Epub 2019 Apr 17.

Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B (CMT1B) neuropathy, one of the most diffused genetic disorders of the PNS. We previously showed that several mutations, such as the deletion of serine 63 (P0-S63del), result in misfolding and accumulation of P0 in the endoplasmic reticulum (ER), with activation of the unfolded protein response (UPR). Read More

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http://dx.plos.org/10.1371/journal.pgen.1008069
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http://dx.doi.org/10.1371/journal.pgen.1008069DOI Listing
April 2019
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Cognitive fatigue and cortical-striatal network in old age.

Aging (Albany NY) 2019 Apr 17. Epub 2019 Apr 17.

School of Nursing, University of Rochester Medical Center, Rochester, NY 14623, USA.

Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. Read More

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http://dx.doi.org/10.18632/aging.101915DOI Listing

Non-Human Primate Vestibulo-Ocular Reflex Responses to Prosthetic Vestibular Stimulation are Robust to Pulse Timing Errors Caused by Temporal Discretization.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Otolaryngolgoy - Head & Neck Surgery, Johns Hopkins University, United States.

Electrical stimulation of vestibular afferent neurons to partially restore semicircular canal sensation of head rotation and the stabilizing reflexes that sensation supports has potential to effectively treat individuals disabled by bilateral vestibular hypofunction. Ideally, a vestibular implant system using this approach would be integrated with a cochlear implant, which would provide clinicians with a means to simultaneously treat loss of both vestibular and auditory sensation. Despite obvious similarities, merging these technologies poses several challenges, including stimulus pulse timing errors that arise when a system must implement a pulse-frequency-modulation encoding scheme (as is used in vestibular implants to mimic normal vestibular nerve encoding of head movement) within fixed-rate continuous interleaved sampling (CIS) strategies used in cochlear implants. Read More

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https://www.physiology.org/doi/10.1152/jn.00887.2018
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http://dx.doi.org/10.1152/jn.00887.2018DOI Listing
April 2019
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Supplemental vibrotactile feedback of real-time limb position enhances precision of goal-directed reaching.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Biomedical Engineering, Marquette University, United States.

We examined vibrotactile stimulation as a form of supplemental limb state feedback to enhance planning and ongoing control of goal-directed movements. Subjects wore a two-dimensional vibrotactile display on their non-dominant arm while performing horizontal planar reaching with the dominant arm. The vibrotactile display provided feedback of hand position such that small hand displacements were more easily discriminable using vibrotactile feedback than with intrinsic proprioceptive feedback. Read More

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http://dx.doi.org/10.1152/jn.00337.2018DOI Listing

Multi-scale modeling of mechanotransduction in the utricle.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Biological Sciences, Ohio University, United States.

We review recent progress in using numerical models to relate utricular hair bundle and otoconial membrane structure to the functional requirements imposed by natural behavior in turtles. Section I reviews the evolution of experimental attempts to understand vestibular system function with emphasis on turtles, including data showing that accelerations occurring during natural head movements achieve higher magnitudes and frequencies than previously assumed. Section 2 reviews quantitative anatomical data documenting topographical variation in the structures underlying macromechanical and micromechanical responses of the turtle utricle to head movement: hair bundles, otoconial membrane (OM), and bundle-OM coupling. Read More

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http://dx.doi.org/10.1152/jn.00068.2019DOI Listing

Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.

J Drug Target 2019 Apr 17:1-25. Epub 2019 Apr 17.

b Medical Physics & Biomedical Engineering, University College London , Gower, Street , London , UK.

Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of diabetic PNP (DPNP) are poorly understood. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1608552DOI Listing

Influence of Axial Length on Parafoveal and Peripapillary Metrics from Swept Source Optical Coherence Tomography Angiography.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a Department of Ophthalmology , 1st affiliated hospital of Xi'an Jiaotong University , Xi'an , Shaanxi , China .

Purpose: To assess the effect of axial length (AL) on the quantification of superficial vessel density of both macular and disc region using swept source optical coherence tomography angiography (SSOCTA).

Methods: This is a cross-sectional clinical study. Seventy-five eyes from 75 Chinese healthy participants (56 females) with a mean age of 26. Read More

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http://dx.doi.org/10.1080/02713683.2019.1607393DOI Listing

Brown adipocytes and β3 stimulant-induced brown-like adipocytes contribute to prevention of renal crystal formation.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Nephro-Urology, Nagoya, Japan.

According to recent studies, kidney stones are associated with metabolic syndrome. We focused on brown adipocytes and β3 stimulant-induced brown-like adipocytes to investigate how these adipocytes influence kidney stone disease. For the interscapular brown adipose tissue (iBAT) removal experiment, mice were subjected to either iBAT removal or sham operation (X-BAT group or Sham group), and after 3 weeks, renal crystal deposition was induced by intra-abdominal injection of glyoxylate (GOX) for 6 days. Read More

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http://dx.doi.org/10.1152/ajprenal.00523.2018DOI Listing

Frequency of Bleeding Complications After Percutaneous Core Needle Biopsy and the Association With Aspirin Usage and Length of Aspirin Discontinuation.

AJR Am J Roentgenol 2019 Apr 17:1-5. Epub 2019 Apr 17.

1 Department of Radiology, Mayo Clinic, 200 First Ave SW, Rochester, MN 55905.

The purpose of this study is to report the frequency of major bleeding after percutaneous image-guided core biopsy and its association with aspirin usage and duration of prebiopsy aspirin abstinence. A retrospective review of percutaneous image-guided core biopsies performed at our institution between September 1, 2005, and September 1, 2016, was performed ( = 30,966). Patients were excluded if aspirin usage data were missing ( = 633). Read More

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http://dx.doi.org/10.2214/AJR.18.20366DOI Listing

Optimizing the Diagnosis of Parkinsonian Syndromes With I-Ioflupane Brain SPECT.

AJR Am J Roentgenol 2019 Apr 17:1-11. Epub 2019 Apr 17.

3 Department of Medical Imaging, University of Arizona, Tucson, AZ.

The purpose of this article is to provide a review of I-ioflupane SPECT in the evaluation of suspected parkinsonian syndromes (PSs). This collection of diseases presents frequent diagnostic challenges, even by movement disorder and dementia specialists. The I-ioflupane scan serves as an imaging biomarker of the status of presynaptic dopamine transporters (DATs) in the striatum. Read More

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http://dx.doi.org/10.2214/AJR.19.21088DOI Listing

Dyslipidemia and the role of the adipose tissue in early pregnancy in the BPH/5 mouse model for preeclampsia.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 17. Epub 2019 Apr 17.

Veterinary Clinical Sciences, Louisiana State University (LSU) School of Veterinary Medicine, United States.

Background: The hypertensive pregnancy disorder preeclampsia (PE) is a leading cause of fetal/ maternal morbidity/mortality. Obesity increases the risk to develop PE, presumably via the release of inflammatory mediators from the adipose tissue, but the exact etiology remains largely unknown.

Methods: Using obese PE-like BPH/5 and lean gestational age-matched C57Bl6 mice, we aimed to obtain insight into differential reproductive white adipose tissue (rWAT) gene expression, circulating lipids and inflammation at the maternal-fetal interface during early pregnancy. Read More

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http://dx.doi.org/10.1152/ajpregu.00334.2018DOI Listing

Heterologous Prime-Boost Enhances the Antitumor Immune Response Elicited by Plant-Virus-Based Cancer Vaccine.

J Am Chem Soc 2019 Apr 16. Epub 2019 Apr 16.

Department of Biomedical Engineering , Case Western Reserve University , 10900 Euclid Avenue , Cleveland , Ohio 44106 , United States.

New cancer vaccine strategies are required to vanquish the self-tolerance and elicit robust immune responses against tumor-associated antigens and/or neoantigens. Contemporary approaches in nanomedicine center on the use of a single nanocarrier modified with multiple copies of multiple different functional domains, e.g. Read More

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http://pubs.acs.org/doi/10.1021/jacs.9b01523
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http://dx.doi.org/10.1021/jacs.9b01523DOI Listing
April 2019
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Nonglucuronidated Ezetimibe Disrupts CD13- and CD64-Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages.

Cytometry A 2019 Apr 17. Epub 2019 Apr 17.

Institute for Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg, 93053 Regensburg, Germany.

Ezetimibe (EZE) and glucuronidated EZE (EZE-Glu) differentially target Niemann-Pick C1-like 1 (NPC1L1) and CD13 (aminopeptidase-N) to inhibit intestinal cholesterol absorption and cholesterol processing in other cells, although the precise molecular mechanisms are not fully elucidated. Cellular effects of EZE, EZE-Glu, and the low-absorbable EZE-analogue S6130 were investigated on human monocyte-derived macrophages upon loading with atherogenic lipoproteins. EZE and S6130, but not EZE-Glu disturbed the colocalization of CD13 and its coreceptor CD64 (Fcγ receptor I) in membrane microdomains, and decreased the presence of both receptors in detergent-resistant membrane fractions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cyto.a.23772
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http://dx.doi.org/10.1002/cyto.a.23772DOI Listing
April 2019
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Optical multiplexed bioassays improve biomedical diagnostics.

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

CHINA.

Conventional analytical methods based on single detection to determine one disease marker are usually not sufficient and accurate because the progression of disease generally involves multiple chemicals and biomolecules. The drive for simultaneous analysis of multiple targets, which plays a key role in both basic biomedical research and clinical applications, demands the development of multiplexed bioassays with high-throughput. In this minireview, we systematically summarize the recent progress of optical multiplexed analytical techniques to improve biomedical diagnostics, in which fluorescence and surface enhanced Raman scattering (SERS) with distinctive optical features are chosen as the main readout signals. Read More

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http://dx.doi.org/10.1002/anie.201901964DOI Listing

A Single Atom Change Facilitates the Membrane Transport of Green Fluorescent Proteins in Mammalian Cells.

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

Indian Institute of Science, Bangalore, 560012, Bangalore, INDIA.

Direct delivery of proteins into mammalian cells is a challenging problem in biological and biomedical applications. The most common strategies for the delivery of proteins into the cells include the use of cell-penetrating peptides or supercharged proteins. Herein, we show for the first time that a single atom change, hydrogen to halogen, at one of the tyrosine residues can increase the cellular entry of 28 kDa green fluorescent protein (GFP) in mammalian cells. Read More

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http://dx.doi.org/10.1002/anie.201902347DOI Listing

GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Glucagon-like peptide-1 (GLP-1) influences energy balance by exerting effects on food intake and glucose metabolism, through mechanisms that are partially dependent on the vagal pathway. The aim of this study was to characterize the effects of chronic GLP-1 stimulation on energy homeostasis and glucose metabolism in the absence of vagal innervation Truncal vagotomized (VGX) and sham operated rats (SHAM) received an intraperitoneal GLP-1 infusion (3.5 pmol/kg/min) trough mini-osmotic pumps. Read More

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http://dx.doi.org/10.1002/jcb.28719DOI Listing

The genetic relationship between alcohol consumption and aspects of problem drinking in an ascertained sample.

Alcohol Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

Background: Genome-wide association studies (GWAS) have begun to identify loci related to alcohol consumption, but little is known about whether this genetic propensity overlaps with specific indices of problem drinking in ascertained samples.

Methods: In 6,731 European-Americans who had been exposed to alcohol, we examined whether polygenic risk scores (PRS) from a GWAS of weekly alcohol consumption in the UK Biobank predicted variance in 6 alcohol-related phenotypes: alcohol use, maximum drinks within 24 hours (MAXD), total score on the self-rating of effects of ethanol questionnaire (SRE-T), DSM-IV alcohol dependence (DSM4AD), DSM-5 alcohol use disorder symptom counts (DSM5AUDSX), and reduction/cessation of problematic drinking. We also examined the extent to which an SNP (rs1229984) in ADH1B, which is strongly associated with both alcohol consumption and dependence, contributed to the polygenic association with these phenotypes and whether PRS interacted with sex, age, or family history of alcoholism to predict alcohol-related outcomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/acer.14064
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http://dx.doi.org/10.1111/acer.14064DOI Listing
April 2019
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H-index and Academic Medicine.

Am J Clin Pathol 2019 Apr 17. Epub 2019 Apr 17.

Biomedical Branch Library University of British Columbia Vancouver, Canada.

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http://dx.doi.org/10.1093/ajcp/aqz037DOI Listing

CAMSAP2 is a microtubule minus-end targeting protein (-TIP) that regulates BTB dynamics through cytoskeletal organization.

Endocrinology 2019 Apr 17. Epub 2019 Apr 17.

The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, NY.

During spermatogenesis, microtubule (MT) cytoskeleton in Sertoli cells confers blood-testis barrier (BTB) function, but the regulator(s) and the mechanism(s) that modulate MT dynamics remains unexplored. Herein, we examined the role of CAMSAP2 (calmodulin-regulated spectrin-associated protein 2, a member of the CAMSAP/Patronin protein family), also a minis (-) end-targeting protein (-TIP) that binds to the minus-end (i.e. Read More

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http://dx.doi.org/10.1210/en.2018-01097DOI Listing

Gravity of the non-authorized use of substances not intended for clinical use in invasive aesthetic procedures: the portuguese case.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):410-418. Epub 2019 Apr 11.

Doctorate in Social Sciences (specialized in Public Administration), Technical University of Lisbon (UTL), Lisbon, Portugal.

Introduction: There is a worldwide increase in the number of invasive aesthetic procedures, and there is a general apprehension in medical societies towards the assurance of patient safety, that is dependent on the quality and certification of providers, of the materials and substances used, and where they take place.It is the main objective of this study to determine the perception of the gravity of non-authorized substances for clinical use in invasive aesthetic procedures among Portuguese plastic surgeons and its variation by the clinical sector of practice.

Methods: We proceeded to an inquiry by using a questionnaire, measured in a Linkert scale, and the collected data were statistically treated with a non-parametric Kruskal-Wallis test. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.410DOI Listing
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