661,095 results match your criteria Biomedical materials Bristol England[Journal]


Segmental colectomy for ulcerative colitis: is there a place in selected patients without active colitis ? An international multicentric retrospective study in 72 patients.

J Crohns Colitis 2020 Jun 4. Epub 2020 Jun 4.

Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Clichy and Université de Paris, France.

Background And Aims: The aim of this study was to report a multicentric experience of segmental colectomy (SC) in ulcerative colitis (UC) patients without active colitis in order to assess if SC can represent or not an alternative to ileal pouch-anal anastomosis (IPAA).

Methods: All UC patients undergoing SC were included. Postoperative complications according to Clavien-Dindo's classification, long- term results and risk factors for postoperative colitis and reoperation for colitis on the remnant colon were assessed. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjaa107DOI Listing

Triboelectric nanogenerators based on graphene oxide coated nanocomposite fibers for biomedical applications.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

Department of Electerical Engineering, Isfahan University of Technology, Isfahan, IRAN, ISLAMIC REPUBLIC OF.

High demand for green and eco-friendly triboelectric nanogenerators (TENGs) have multiplied the importance of their degradability for biomedical applications. However, the charge generation of the current eco-friendly TENGs is generally limited. In this research, a flexible TENG based on Silk fibroin (SF) fibrous layer and polycaprolactone (PCL)/graphene oxide (GO) fibrous layer was developed. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9972DOI Listing

A modular high-density μECoG system on macaque vlPFC for auditory cognitive decoding.

J Neural Eng 2020 Jun 4. Epub 2020 Jun 4.

Biomedical Engineering, Duke University, Durham, North Carolina, UNITED STATES.

Objective: A fundamental goal of the auditory system is to parse the auditory environment into distinct perceptual representations. Auditory perception is mediated by the ventral auditory pathway, which includes the ventrolateral prefrontal cortex (vlPFC). Because large-scale recordings of auditory signals are quite rare, the spatiotemporal resolution of the neuronal code that underlies vlPFC's contribution to auditory perception has not been fully elucidated. Read More

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http://dx.doi.org/10.1088/1741-2552/ab9986DOI Listing

Pulse rate variability in cardiovascular health: a review on its applications and relationship with heart rate variability.

Physiol Meas 2020 Jun 4. Epub 2020 Jun 4.

School of Mathematics Computer Science and Engineering, City University London, Northampton Square, London EC1V 0HB, UK, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Heart rate variability has been largely used for the assessment of cardiac autonomic activity, due to the direct relationship between cardiac rhythm and the activity of the sympathetic and parasympathetic nervous system. In recent years, another technique, pulse rate variability , has been used for assessing heart rate variability information from pulse wave signals, especially from photoplethysmography, a non-invasive, non-intrusive, optical technique that measures the blood volume in tissue. The relationship, however, between pulse rate variability and heart rate variability is not entirely understood, and the effects of cardiovascular changes in pulse rate variability have not been thoroughly dilucidated. Read More

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http://dx.doi.org/10.1088/1361-6579/ab998cDOI Listing

NAD(P)-dependent glucose dehydrogenase: Applications for biosensors, bioelectrodes, and biofuel cells.

Bioelectrochemistry 2020 May 23;135:107574. Epub 2020 May 23.

Faculty of Chemistry, University of Warsaw, Pasteura St. 1, 02-093 Warsaw, Poland. Electronic address:

This review discusses the physical and chemical properties of nicotinamide redox cofactor dependent glucose dehydrogenase (NAD(P) dependent GDH) and its extensive application in biosensors and bio-fuel cells. GDHs from different organisms show diverse biochemical properties (e.g. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2020.107574DOI Listing

Bone health in neuromyelitis optica: Bone mineral density and fractures.

Mult Scler Relat Disord 2020 Apr 28;42:102080. Epub 2020 Apr 28.

Department of Neurology, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea; Department of Neurology, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: The bone health in neuromyelitis optica spectrum disorder with aquaporin-4 immunoglobulin G antibodies (NMOSD-AQP4) have not been fully evaluated. To evaluate the prevalence of fractures and bone loss in patients with NMOSD-AQP4 compared to healthy controls and patients with multiple sclerosis (MS) and to identify the risk factors associated with fractures and low bone mineral density (BMD) in patients with NMOSD-AQP4.

Methods: Seventy-one patients with NMOSD-AQP4 were included. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102080DOI Listing

Foreword to the special issue on zebrafish imaging: Emerging techniques and methodologies.

Micron 2020 May 14;136:102877. Epub 2020 May 14.

Victor Chang Cardiac Research Institute, NSW, 2010, Darlinghurst, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.micron.2020.102877DOI Listing

Gait features for discriminating between mobility-limiting musculoskeletal disorders: Lumbar spinal stenosis and knee osteoarthritis.

Gait Posture 2020 May 19;80:96-100. Epub 2020 May 19.

Division of Physical Medicine and Rehabilitation, Stanford University, Stanford, CA, United States.

Background: Functional ambulation limitations are features of lumbar spinal stenosis (LSS) and knee osteoarthritis (OA). With numerous validated walking assessment protocols and a vast number of spatiotemporal gait parameters available from sensor-based assessment, there is a critical need for selection of appropriate test protocols and variables for research and clinical applications.

Research Question: In patients with knee OA and LSS, what are the best sensor-derived gait parameters and the most suitable clinical walking test to discriminate between these patient populations and controls?

Methods: We collected foot-mounted inertial measurement unit (IMU) data during three walking tests (fast-paced walk test-FPWT, 6-min walk test- 6MWT, self-paced walk test - SPWT) for subjects with LSS, knee OA and matched controls (N = 10 for each group). Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.019DOI Listing

A review of optical breast imaging: Multi-modality systems for breast cancer diagnosis.

Eur J Radiol 2020 May 18;129:109067. Epub 2020 May 18.

Department of Radiology, Washington University in St Louis, MO 63110, United States. Electronic address:

This review of optical breast imaging describes basic physical and system principles and summarizes technological evolution with a focus on multi-modality platforms and recent clinical trial results. Ultrasound-guided diffuse optical tomography and co-registered ultrasound and photoacoustic imaging systems are emphasized as models of state of the art optical technology that are most conducive to clinical translation. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109067DOI Listing

Identification of low molecular weight degradation products from chitin and chitosan by electrospray ionization time-of-flight mass spectrometry.

Carbohydr Res 2020 May 25;493:108046. Epub 2020 May 25.

Department of Chemistry, Colorado State University, 1801 Campus Delivery, Fort Collins, CO, 80523, United States; Department of Chemical and Biological Engineering, Colorado State University, 1370 Campus Delivery, Fort Collins, CO, 80523, United States; School of Biomedical Engineering, Colorado State University, 1376 Campus Delivery, Fort Collins, CO, 80523, United States. Electronic address:

The beneficial effects provided by chitosan oligosaccharides (COS) make them of interest in medical research. The monomers that constitute COS confer distinct properties, so controlling COS composition during their production is significant. In this work, we degraded chitin and chitosan polymers and identified low molecular weight products such as COS that formed, using electrospray ionization time-of-flight mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.carres.2020.108046DOI Listing

Hepatocarcinogen 4-methylquinoline induced G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (Muta™Mouse).

Mutat Res 2020 May 23;821:111709. Epub 2020 May 23.

College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan; Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan. Electronic address:

We have previously reported that quinoline increased the mutation frequency of the cII gene in the liver of lambda/lacZ transgenic mice (Muta™Mouse), and G:C to C:G transversions were the molecular signature of quinoline-induced mutations. 4-Methylquinoline (4-MeQ) has the highest mutagenicity among quinoline and isomeric methylquinolines according to the Ames test using Salmonella typhimurium TA 100, in the presence of rat liver microsomal enzymes. In this report, we examined the effect of 4-MeQ on mutagenesis in the lambda cII gene in the liver of the Muta™Mouse, and we analyzed the sequences of the mutated genes. Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2020.111709DOI Listing

Dextran stabilized fullerene soot induced toxicity on alveolar epithelial cells (A549 cells).

Environ Res 2020 May 26;188:109716. Epub 2020 May 26.

Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum, 695 012, Kerala, India. Electronic address:

Fullerene comprises the major allotrope of carbon holding several fruitful potentials to be applied in various industrial and biomedical scenarios. Scientists have acquired large number of data on fullerene research using its derivatives like C60, C70 etc. Nevertheless, a precise focus on fullerene soot nanopaticles and its toxic impacts in living tissue is still behind mainstay even if it represents the crude parent form of all other derivatives. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109716DOI Listing

Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats.

Biomed Pharmacother 2020 Jun 1;128:110304. Epub 2020 Jun 1.

Department of Pharmacology, Guangdong Medical University, Zhanjiang, Guangdong, 524023, PR China. Electronic address:

Background And Aims: Aging-induced bone loss is a multifactorial, age-related, and progressive phenomenon among the general population and may further progress to osteoporosis and increase the risk of fractures. Cycloastragenol (CAG), currently the only compound reported that activates human telomerase, is thought to be able to alleviate or delay the symptoms of aging and chronic diseases. Previous research has suggested that CAG may have the potential to alleviate age-related bone loss. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110304DOI Listing

The implementation of an integrated e-leprosy framework in a leprosy control program at primary health care centers in Indonesia.

Int J Med Inform 2020 May 11;140:104155. Epub 2020 May 11.

Faculty of Computer Science, Universitas Dian Nuswantoro, No 127, Imam Bonjol Street, Semarang City, Central Java, 50131, Indonesia. Electronic address:

Background And Objective: The implementation of health information systems (HIS) could overcome obstacles in human resources and infrastructure at primary health care centers (PHCs). This study involved an e-Leprosy framework being integrated into the real setting of a leprosy control program in Indonesia. The objectives of this implementation study were to integrate e-Leprosy into a leprosy control program at 27 PHCs in Pekalongan District. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2020.104155DOI Listing

Structure-activity relationships in a series of auranofin analogues showing remarkable antiproliferative properties.

J Inorg Biochem 2020 Mar 28;208:111079. Epub 2020 Mar 28.

Department of Health Sciences, University of Florence, Florence, Italy.

The antiproliferative properties of a series of structurally-related gold(I) and silver(I) linear complexes inspired to the clinically established gold-based drug auranofin were investigated in A2780 ovarian cancer cells and in their auranofin (A2780/AF-R) and cisplatin (A2780/CDDP-R) resistant counterparts. In A2780 cells and in the cisplatin-resistant subline, gold-based analogues manifested a cytotoxicity profile comparable or superior to auranofin, while the silver-based analogues were less active; both gold and silver complexes overcame cisplatin resistance. Yet, a high degree of cross resistance toward gold analogues was noticed in A2780/AF-R cells. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111079DOI Listing

Molecular Detection of Occult Hepatitis B virus in plasma and urine of renal transplant patients in Khartoum state Sudan.

Int J Infect Dis 2020 Jun 1. Epub 2020 Jun 1.

Department of Molecular Biology, National University Biomedical Research Institute, National University-Sudan, Khartoum- Sudan. Electronic address:

Objective: The aim of this study was to determine the OBI in plasma and urine samples from renal transplant patients using Multiplex Nested PCR.

Method: A total of 100 samples (plasma and urine) were collected from renal transplant patients admitted to the renal transplant center in Khartoum north, Sudan in 2019. For each sample, HBsAg, HBeAg and anti HBcAg were detected using Enzyme linked Immune sorbent assay (ELISA). Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.101DOI Listing

Molecular modelling analysis of T219A mutant envelope protein revealed novel virulence enhancing factors in Dengue virus isolated from Kerala state, India.

Comput Methods Programs Biomed 2020 May 24;195:105481. Epub 2020 May 24.

Biomedical Informatics Centre, Vector Control Research Center, Indian Council of Medical Research, Pondicherry, India, 605006.

Dengue virus (DENV) is an emerging health threat and its envelope glycoprotein E, is involved in the anchoring and fusion mechanisms. Anchoring followed by conformational changes of E-protein are responsible for the fusion and entry of DENV into host. The variation in the conformation of the E-protein due to mutations, results in its altered binding with antibodies (Abs) and also its receptors. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105481DOI Listing

After the COVID 19 outbreak in Italy: What have we learnt?

Travel Med Infect Dis 2020 Jun 1:101761. Epub 2020 Jun 1.

Department of Biomedical Sciences for Health, University of Milan - ASST Fatebenefratelli - Sacco, Milan, Italy.

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http://dx.doi.org/10.1016/j.tmaid.2020.101761DOI Listing

Special Communication: Evaluation and Treatment of Thoracic Outlet Syndrome During the Global Pandemic Due to SARS-CoV-2 and COVID-19.

J Vasc Surg 2020 Jun 1. Epub 2020 Jun 1.

The Center for Thoracic Outlet Syndrome and the Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO. Electronic address:

The global SARS-CoV-2/COVID-19 pandemic has required a reduction in non-emergency treatment for a variety of disorders. This report summarizes conclusions of an international multidisciplinary consensus group assembled to address evaluation and treatment of patients with thoracic outlet syndrome (TOS), a group of conditions characterized by extrinsic compression of the neurovascular structures serving the upper extremity. The following recommendations were developed in relation to the 3 defined types of TOS (neurogenic, venous, and arterial) and 3 phases of pandemic response (preparatory, urgent with limited resources, and emergency with complete diversion of resources): (1) In-person evaluation and treatment for neurogenic TOS (interventional or surgical) is generally postponed during all pandemic phases, with telephone/telemedicine visits and at-home physical therapy exercises recommended when feasible. Read More

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http://dx.doi.org/10.1016/j.jvs.2020.05.048DOI Listing

Review of Methods for Detecting Glycemic Disorders.

Diabetes Res Clin Pract 2020 Jun 1:108233. Epub 2020 Jun 1.

Department of Endocrinology and Diabetology, Université Catholique de Louvain, University Clinic Saint-Luc, Brussels, Belgium. Electronic address:

Prediabetes (intermediate hyperglycemia) consists of two abnormalities, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) detected by a standardized 75-gram oral glucose tolerance test (OGTT). Individuals with isolated IGT or combined IFG and IGT have increased risk for developing type 2 diabetes (T2D) and cardiovascular disease (CVD). Diagnosing prediabetes early and accurately is critical in order to refer high-risk individuals for intensive lifestyle modification. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108233DOI Listing

Click Cross-linking Improves Retention and Targeting of Refillable Alginate Depots.

Acta Biomater 2020 Jun 1. Epub 2020 Jun 1.

Joint Department of Biomedical Engineering. University of North Carolina - Chapel Hill and North Carolina State University - Raleigh. 1840 Entrepreneur Drive. Raleigh, NC 27695, USA. Electronic address:

Injectable alginate hydrogels have demonstrated utility in tissue engineering and drug delivery applications due in part to their mild gelation conditions, low host responses and chemical versatility. Recently, the potential of these gels has expanded with the introduction of refillable hydrogel depots - alginate gels chemically decorated with click chemistry groups to efficiently capture prodrug refills from the blood. Unfortunately, high degrees of click group substitution on alginate lead to poor viscoelastic properties and loss of ionic cross-linking. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.033DOI Listing

A novel approach to modeling multifactorial diseases using Ensemble Bayesian Rule Classifiers.

J Biomed Inform 2020 Jun 1:103455. Epub 2020 Jun 1.

School of Computing and Information, Intelligent Systems Program, University of Pittsburgh, 135 N Bellefield Ave, Pittsburgh, PA 15213; Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Boulevard, Suite 500, Pittsburgh, PA 15206.

Modeling factors influencing disease phenotypes, from biomarker profiling study datasets, is a critical task in biomedicine. Such datasets are typically generated from high-throughput 'omic' technologies, which help examine disease mechanisms at an unprecedented resolution. These datasets are challenging because they are high-dimensional. Read More

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http://dx.doi.org/10.1016/j.jbi.2020.103455DOI Listing

Florida Research Open-source Synchronization Tool (FROST) for electrophysiology experiments.

J Neurosci Methods 2020 Jun 1:108800. Epub 2020 Jun 1.

J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States; Department of Neuroscience, University of Florida, Gainesville, FL, United States.

Background: Accurate interpretation of electrophysiological data in cognitive and behavioral experiments requires the acquisition of time labels, such as marking the exact start of a condition or moment a stimulus is presented to a research subject.

New Method: Here we present an inexpensive (∼30 USD) device used as a central relay for multiple peripheral devices, such as a computer screen presenting an experiment, a pressure-sensor push button, a multi-button responder, a pulse oximeter sensor, a light-emitting diode trigger for camera synchronization, and so on. We refer to this device as the Florida Research Open-source Synchronization Tool (FROST). Read More

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http://dx.doi.org/10.1016/j.jneumeth.2020.108800DOI Listing

Surface modification and bioconjugation of anti-CD4 monoclonal antibody to magnetic nanoparticles as a highly efficient affinity adsorbent for positive selection of peripheral blood T CD4+ lymphocytes.

Int J Biol Macromol 2020 Jun 1. Epub 2020 Jun 1.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran; Immunology Research Center (IRC), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Magnetic activated cell sorting (MACS) is a straightforward and time-saving procedure for isolation of different healthy functional cells. The present study aimed for the developing of a new MACS-based platform for isolation of peripheral blood T CD4+ lymphocytes. For this goal, first: FeO magnetic nanoparticles (MNP) were prepared by co-precipitation of Fe (III) and Fe (II) ions and then coated by SiO shell, followed by the grafting of N-(phosphonomethyl) iminodiacetic acid (PMIDA) on the surface of fabricated MNP, FeO@SiO@PMIDA were formed. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.264DOI Listing

Laccase-mediated construction of flexible double-network hydrogels based on silk fibroin and tyramine-modified hyaluronic acid.

Int J Biol Macromol 2020 Jun 1. Epub 2020 Jun 1.

Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, Jiangnan University, Wuxi 214122, People's Republic of China.

Silk fibroin (SF) is a promising biomaterial with attractive properties, however, the practical applications of pure regenerated SF materials were severely restricted by their poor water retention and low elasticity. In this study, a tyramine-modified hyaluronic acid (mHA) was introduced to SF chains, followed by constructing double-network hydrogels via laccase-mediated crosslinking of SF and mHA. Mechanism of the enzymatic coupling reaction between SF and mHA was investigated using the model compounds. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.258DOI Listing

Preparation of polymyxin B-loaded gellan-polylysine polyion complex fibers with high affinity to endotoxin.

Int J Biol Macromol 2020 Jun 1. Epub 2020 Jun 1.

Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:

Endotoxemia, a life-threatening disease affecting people worldwide, can be treated by hemoperfusion alone. New hemoperfusion materials with high biocompatibility and endotoxin-combination ability are always in demand. Herein, polymyxin B (PMB), a specific endotoxin binding molecule, was loaded onto gellan-polylysine polyion complex, and the obtained material was used in preparing wet-spun fibers. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.263DOI Listing

Phenotypic characteristics of patients with Chronic Obstructive Pulmonary Disease after stratification for the Short Physical Performance Battery summary score.

Arch Phys Med Rehabil 2020 Jun 1. Epub 2020 Jun 1.

Department of Research and Development, CIRO, Horn, the Netherlands; Reval Rehabilitation Research - Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium; Department of Respiratory Medicine, Maastricht University Medical Centre (MUMC+), NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.

Objective: To assess the phenotypic characteristics of patients with Chronic Obstructive Pulmonary Disease (COPD) after stratification for Short Physical Performance Battery (SPPB) summary scores and to determine phenotypic characteristics of the SPPB summary score at the start of pulmonary rehabilitation (PR).

Design: Retrospective, cross-sectional.

Setting: Baseline assessment for PR program. Read More

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http://dx.doi.org/10.1016/j.apmr.2020.05.011DOI Listing

Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis.

Comp Biochem Physiol B Biochem Mol Biol 2020 Jun 1:110461. Epub 2020 Jun 1.

Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa K1S 5B6, Canada. Electronic address:

In arid conditions, the African Clawed frog Xenopus laevis enters a state of estivation dormancy as an adaptive survival strategy. Under estivation, X. laevis experience severe dehydration stress as 25-35% of total body water is lost. Read More

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http://dx.doi.org/10.1016/j.cbpb.2020.110461DOI Listing

Effect of EnChroma glasses on color vision screening using Ishihara and Farnsworth D-15 color vision tests.

J AAPOS 2020 Jun 1. Epub 2020 Jun 1.

Department of Ophthalmology, Ross Eye Institute, University at Buffalo, Buffalo, New York.

Background: The prevalence of color vision deficiency (CVD) is about 0.5% in females and 8% in males. Although there is no cure for CVD, specially filtered glasses are purported to improve color contrast. Read More

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http://dx.doi.org/10.1016/j.jaapos.2020.03.006DOI Listing

Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer.

J Control Release 2020 Jun 1. Epub 2020 Jun 1.

Institute of Biomedical Sciences, Research Center, Academia Sinica, Taipei 11529, Taiwan; the Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei 10051, Taiwan. Electronic address:

Lung cancer is the primary cause of cancer-related death worldwide. 85%-90% of cases are non-small cell lung cancer (NSCLC) which characteristically exhibits altered epidermal growth factor receptor (EGFR) signaling is a major driver pathway. Unfortunately, therapeutic outcomes in treating NSCLC are compromised by the emergence of drug resistance in response to EGFR-tyrosine kinase inhibitor (TKI) targeted therapy due to the acquired resistance mutation EGFR T790M or activation of alternative pathways. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.05.043DOI Listing

Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools.

Toxicol Lett 2020 Jun 1. Epub 2020 Jun 1.

Penman Consulting Limited, Wantage, UK. Electronic address:

This paper derives an occupational exposure limit for benzene using quality assessed data. Seventy-seven genotoxicity and 36 haematotoxicity studies in workers were scored for study quality with an adapted tool based on that of Vlaanderen et al, 2008 (Environ Health. Perspect. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.05.036DOI Listing

Population-specific profiling of CCL3L1 copy number of the three major ethnic groups in Malaysia and the implication on HIV susceptibility.

Gene 2020 Jun 1:144821. Epub 2020 Jun 1.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

CC chemokine ligand 3 like-1 (CCL3L1) encodes for CCL3L1 protein, which is a human immunodeficiency virus (HIV) suppressive chemokine and a potent ligand of HIV CCR5 co-receptor. CCL3L1 exhibits variation in the gene copy number (CN) and could influence HIV susceptibility through gene dosage effect. The study aims to determine the distribution of CCL3L1 CN among HIV subjects of Malay, Chinese, and Indian ethnics in Malaysia and to evaluate the impact of CCL3L1 CN on susceptibility to HIV. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144821DOI Listing

mA Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.

Immunity 2020 May 31. Epub 2020 May 31.

Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

N-methyladenosine (mA) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the mA writer METTL3 in murine fetal liver resulted in hematopoietic failure and perinatal lethality. Loss of METTL3 and mA activated an aberrant innate immune response, mediated by the formation of endogenous double-stranded RNAs (dsRNAs). Read More

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http://dx.doi.org/10.1016/j.immuni.2020.05.003DOI Listing

Breast Milk Modulates Transgenerational Immune Inheritance.

Cell 2020 Jun 1. Epub 2020 Jun 1.

Maurice Müller Laboratories (Department for BioMedical Research), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3008 Bern, Switzerland. Electronic address:

ROR-γt regulatory T cells (Tregs) of the colon can prevent excessive inflammation but also delay pathogen clearance. How these cells are regulated has remained elusive. In this issue of Cell, Ramanan et al. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.030DOI Listing

High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down.

Mol Cell 2020 May 29. Epub 2020 May 29.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

The identification of microRNA (miRNA) targets by Ago2 crosslinking-immunoprecipitation (CLIP) methods has provided major insights into the biology of this important class of non-coding RNAs. However, these methods are technically challenging and not easily applicable to an in vivo setting. To overcome these limitations and facilitate the investigation of miRNA functions in vivo, we have developed a method based on a genetically engineered mouse harboring a conditional Halo-Ago2 allele expressed from the endogenous Ago2 locus. Read More

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http://dx.doi.org/10.1016/j.molcel.2020.05.009DOI Listing

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.

Mol Cell 2020 May 27. Epub 2020 May 27.

Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Cancer Center, Tulane University School of Medicine, 1430 Tulane Ave., New Orleans, LA 70112, USA. Electronic address:

Human tumors with exonuclease domain mutations in the gene encoding DNA polymerase ε (POLE) have incredibly high mutation burdens. These errors arise in four unique mutation signatures occurring in different relative amounts, the etiologies of which remain poorly understood. We used CRISPR-Cas9 to engineer human cell lines expressing POLE tumor variants, with and without mismatch repair (MMR). Read More

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http://dx.doi.org/10.1016/j.molcel.2020.05.012DOI Listing

ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization.

Dev Cell 2020 May 27. Epub 2020 May 27.

Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Japan Science and Technology Agency, PRESTO, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission is coordinated with intracellular biochemical signaling to achieve collective movements. Here, we show that intercellular coupling of extracellular signal-regulated kinase (ERK)-mediated mechanochemical feedback yields long-distance transmission of guidance cues. Read More

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http://dx.doi.org/10.1016/j.devcel.2020.05.011DOI Listing

Fundamentals of Microscopy.

Authors:
Jeremy Sanderson

Curr Protoc Mouse Biol 2020 Jun;10(2):e76

Bioimaging Facility Manager, MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.

The light (or optical) microscope is the icon of science. The aphorism "seeing is believing" is often quoted in scientific papers involving microscopy. Unlike many scientific instruments, the light microscope will deliver an image however badly it is set up. Read More

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http://dx.doi.org/10.1002/cpmo.76DOI Listing

Reverse quarantine: Management of COVID-19 by Kerala with its higher number of aged population.

Psychogeriatrics 2020 Jun 4. Epub 2020 Jun 4.

Kerala Chapter (Convenor), National Academy of Medical Sciences (India), Ansari Nagar, New Delhi, 110029, India.

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http://dx.doi.org/10.1111/psyg.12582DOI Listing

An immediate hypersensitivity reaction induced by PEGylated recombinant factor VIII.

Haemophilia 2020 Jun 4. Epub 2020 Jun 4.

Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi, Japan.

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http://dx.doi.org/10.1111/hae.14048DOI Listing

Delicate Balance of Non-Covalent Forces Govern the Biocompatibility of Graphitic Carbon Nitride towards Genetic Materials.

Chemphyschem 2020 Jun 4. Epub 2020 Jun 4.

Indian Association for the Cultivation of Science, Department of Spectroscopy, 2A & 2B Raja Subodh Mallick Road, Jadavpur, 700032, Kolkata, INDIA.

Despite a plethora of suggested technological and biomedical applications, the nanotoxicity of two-dimensional (2D) graphitic carbon nitride (g-C3N4) towards biomolecules remains elusive. To address this issue, we employ all-atom classical molecular dynamics simulations and investigate the interactions between nucleic acids and g-C3N4. It is revealed that, toxicity is modulated through a subtle balance between electrostatic and van der Waals interactions. Read More

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http://dx.doi.org/10.1002/cphc.202000385DOI Listing

GLAST-CreER mediated deletion of GDNF increases brain damage and exacerbates long-term stroke outcomes after focal ischemic stroke in mouse model.

Glia 2020 Jun 4. Epub 2020 Jun 4.

Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA.

Focal ischemic stroke (FIS) is a leading cause of human death. Glial scar formation largely caused by reactive astrogliosis in peri-infarct region (PIR) is the hallmark of FIS. Glial cell-derived neurotrophic factor (GDNF) was originally isolated from a rat glioma cell-line supernatant and is a potent survival neurotrophic factor. Read More

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http://dx.doi.org/10.1002/glia.23848DOI Listing

Increasing Host Cellular Receptor-Angiotensin-Converting Enzyme 2 (ACE2) Expression by Coronavirus may Facilitate 2019-nCoV (or SARS-CoV-2) Infection.

J Med Virol 2020 Jun 4. Epub 2020 Jun 4.

Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

The ongoing outbreak of a new coronavirus (2019-nCoV, or SARS-CoV-2) has caused an epidemic of the acute respiratory syndrome known as COVID-19 in humans. SARS-CoV-2 rapidly spread to multiple regions of China and multiple other countries, posing a serious threat to public health. The spike (S) proteins of SARS-CoV-1 and SARS-CoV-2 may use the same host cellular receptor, angiotensin-converting enzyme 2 (ACE2), for entering into host cells. Read More

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http://dx.doi.org/10.1002/jmv.26139DOI Listing

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2.

Angew Chem Int Ed Engl 2020 Jun 4. Epub 2020 Jun 4.

Uppsala University, Department of Medicinal Chemistry, Husaragatan 3, Biomedical Center, Box 574, 75123, Uppsala, SWEDEN.

N-Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has previously been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines and hydrazines. Here, we demonstrate that the human arylamine N-acetyltransferase NAT2 also acetylates a series of aliphatic endogenous amines. Read More

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http://dx.doi.org/10.1002/anie.202005915DOI Listing

Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus.

J Neurochem 2020 Jun 4. Epub 2020 Jun 4.

Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.

In the visual system, retinal axons convey visual information from the outside world to dozens of distinct retinorecipient brain regions and organize that information at several levels, including either at the level of retinal afferents, cytoarchitecture of intrinsic retinorecipient neurons, or a combination of the two. Two major retinorecipient nuclei which are densely innervated by retinal axons are the dorsal lateral geniculate nucleus (dLGN), which is important for classical image-forming vision, and ventral LGN (vLGN), which is associated with non-image-forming vision. The neurochemistry, cytoarchitecture, and retinothalamic connectivity in vLGN remain unresolved, raising fundamental questions of how it receives and processes visual information. Read More

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http://dx.doi.org/10.1111/jnc.15101DOI Listing

Lemon balm and dandelion leaf extract synergistically alleviate ethanol-induced hepatotoxicity by enhancing antioxidant and anti-inflammatory activity.

J Food Biochem 2020 Jun 4:e13232. Epub 2020 Jun 4.

Department of Foodscience and Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea.

We investigated the effect of a 2:1 (w/w) mixture of lemon balm and dandelion extracts (LD) on ethanol (EtOH)-mediated liver injury and explored the underlying mechanisms. Administration of LD synergistically reduced relative liver weight and decreased the levels of serum biomarkers of hepatic injury. Histopathological and biochemical analyses indicated that LD synergistically attenuated hepatic accumulation of triacylglycerides (TGs) and restored the levels of mRNAs related to fatty acid metabolism. Read More

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http://dx.doi.org/10.1111/jfbc.13232DOI Listing

Moderate early life stress improves adult zebrafish (Danio rerio) working memory but does not affect social and anxiety-like responses.

Dev Psychobiol 2020 Jun 4. Epub 2020 Jun 4.

Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.

Early life stress (ELS) is defined as a short or chronic period of trauma, environmental or social deprivation, which can affect different neurochemical and behavioral patterns during adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human neurodevelopmental disorders and display translationally relevant behavioral and stress-regulating systems. In this study, we aimed to investigate the effects of moderate ELS by exposing young animals (6-weeks postfertilization), for 3 consecutive days, to three stressors, and analyzing the impact of this on adult zebrafish behavior (16-week postfertilization). Read More

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http://dx.doi.org/10.1002/dev.21986DOI Listing

Engineered citrate synthase improves citramalic acid generation in Escherichia coli.

Biotechnol Bioeng 2020 Jun 4. Epub 2020 Jun 4.

School of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, GA, 30602, USA.

The microbial product citramalic acid (citramalate) serves as a five-carbon precursor for the chemical synthesis of methacrylic acid. This biochemical is synthesized in Escherichia coli directly by the condensation of pyruvate and acetyl-CoA via the enzyme citramalate synthase. The principal competing enzyme with citramalate synthase is citrate synthase, which mediates the condensation reaction of oxaloacetate and acetyl-CoA to form citrate and begin the tricarboxylic acid cycle. Read More

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http://dx.doi.org/10.1002/bit.27450DOI Listing

Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes.

Clin Endocrinol (Oxf) 2020 Jun 4. Epub 2020 Jun 4.

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Objective: Distal symmetrical polyneuropathy (DSPN) is a severe common long-term complication of type 1 diabetes caused by impaired sensory-motor nerve function. As chronic low-grade inflammation may be involved in the pathogenesis of DSPN, we investigated the circulating levels of inflammatory markers in individuals with type 1 diabetes with and without DSPN. Furthermore, we determined to what extent these factors correlated with different peripheral sensory nerve functions. Read More

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http://dx.doi.org/10.1111/cen.14261DOI Listing

Host-pathogen interaction in the tissue environment during Plasmodium blood-stage infection.

Parasite Immunol 2020 Jun 4:e12763. Epub 2020 Jun 4.

Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4, Sakamoto, Nagasaki, 852-8523, Japan.

Human malarial infection occurs after an infectious Anopheles mosquito bites. Following the initial liver-stage infection, parasites transform into merozoites, infecting red blood cells (RBCs). Repeated RBC infection then occurs during the blood-stage infection, while patients experience various malarial symptoms. Read More

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http://dx.doi.org/10.1111/pim.12763DOI Listing
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