573,811 results match your criteria Biomedical Papers-olomouc[Journal]


PTEN-deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Cancer Biology and Genetics, Queen's Cancer Research Institute, Queen's University, Kingston, Canada.

Background: Accumulating evidence shows that tumor cell-specific genomic changes can influence the cross talk between cancer cells and the surrounding tumor microenvironment (TME). Loss of the PTEN tumor suppressor gene is observed in 20% to 30% of prostate cancers (PCa) when first detected and the rate increases with PCa progression and advanced disease. Recent findings implicate a role for PTEN in cellular type I interferon response and immunosuppression in PCa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.23808DOI Listing

The Mealtime Assessment Scale (MAS): Part 1 - Development of a Scale for Meal Assessment.

Folia Phoniatr Logop 2019 Apr 18:1-13. Epub 2019 Apr 18.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: Safety and efficacy of swallowing in instrumental assessment may not overlap safety and efficacy of swallowing during meal, as personal and environmental factors can influence the performance. This study aims to develop a scale to assess the safety and efficacy of swallowing during meal.

Methods: A working group discussed the latent construct, target population, and purposes of the scale. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/494135
Publisher Site
http://dx.doi.org/10.1159/000494135DOI Listing
April 2019
1 Read

Cutaneous perfusion of the human lactating breast: a pilot study with laser Doppler perfusion monitoring.

Physiol Meas 2019 Apr 18. Epub 2019 Apr 18.

Biomedical Photonic Imaging, University of Twente, Drienerlolaan 5, building Zuidhorst 256, Enschede, Overijssel, 7500AE, NETHERLANDS.

<i>Objective</i>: Knowledge on the hemodynamics of the human lactating breast contributes to our understanding of lactation physiology, as well as the development and management of breastfeeding problems. The objective of this pilot study was to investigate whether laser Doppler perfusion monitoring (LDPM) can be employed to measure physiological changes in mammary cutaneous perfusion during milk extraction. <i>Approach</i>: We evaluated mammary cutaneous perfusion with LDPM in 9 lactating women during milk extraction in both the ipsilateral ('milk extracting') and contralateral ('passive') breast. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6579/ab1ad7DOI Listing

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.

Stem Cell Res 2019 Apr 10;37:101434. Epub 2019 Apr 10.

Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA. Electronic address:

Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine. Increasingly, laboratories are creating their own banks of iPSCs derived from diverse donors. However, there are not yet standardized guidelines for qualifying these cell lines, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2019.101434DOI Listing

Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines.

Bioorg Chem 2019 Apr 11;88:102918. Epub 2019 Apr 11.

Department of Chemistry, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway. Electronic address:

The epidermal growth factor receptor represents an important target in cancer therapy, and low molecular weight inhibitors based on quinazolines have reached the marked. Herein we report on a new scaffold, 5-aryl-7H-pyrrolo[2,3-d]pyrimidin-4-amines, and show that when employing (S)-phenylglycinol as C-4 substituent, potent inhibitors can be made. The two most active inhibitors have suitable druglike properties, were equipotent with Erlotinib in Ba/F3 cell studies, and showed lower cross reactivity than Erlotinib in a panel of 50 kinases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioorg.2019.102918DOI Listing

Exposure effects of endotoxin-free titanium-based wear particles to human osteoblasts.

J Mech Behav Biomed Mater 2019 Apr 10;95:143-152. Epub 2019 Apr 10.

Department of Physics, UNESP, São Paulo State University, 17033-360, Bauru, SP, Brazil.

Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, wear, and tribocorrosion. As a consequence, metallic ions or particles (debris) may be released, and although several studies have been conducted in recent years to better understand the effects of their exposure to living cells, a consensual opinion has not yet been obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmbbm.2019.04.003DOI Listing

Molecular regulation of myoendothelial gap junctions.

Curr Opin Pharmacol 2019 Apr 15;45:16-22. Epub 2019 Apr 15.

Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, Biomedical Centre, Cardiovascular Physiology, LMU Munich and German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.

Myoendothelial gap junctions are involved in the regulation of vascular tone. The major connexins described in the vascular system are Cx37, Cx40, Cx43, and Cx45 with all but Cx45 found in myoendothelial connections. Although many reports on post-translational modifications of these connexins are available, only few groups have investigated their role in controlling myoendothelial communication and signal propagation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2019.03.006DOI Listing

The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis.

Mol Plant 2019 Apr 15. Epub 2019 Apr 15.

Shanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences, Shanghai, China; John Innes Centre, Norwich, NR4 7UH UK. Electronic address:

Scutellaria baicalensis Georgi is important in Chinese Traditional Medicine where preparations of dried roots, 'Huang Qin', are used for liver and lung complaints including complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S16742052193013
Publisher Site
http://dx.doi.org/10.1016/j.molp.2019.04.002DOI Listing
April 2019
12 Reads

Egg white coated alginate nanoparticles with electron sprayer for potential anticancer application.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

Research Institute of Sun Yat-Sen University in Shenzhen, Shenzhen, 518057, PR China; Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address:

To development biomimetic strategy for enhanced cancer therapy, the paclitaxel loaded egg white/sodium alginate nanoparticles were prepared by electronic spray method. Their appearance and particle size were observed by transmission electron microscope and particle size analyzer. The drug release behavior of nanoparticles was determined by high performance liquid chromatography (HPLC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.04.045DOI Listing

Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing

The historical development of pharmacopoeias and the inclusion of exotic herbal drugs with a focus on Europe and Brazil.

J Ethnopharmacol 2019 Apr 15:111891. Epub 2019 Apr 15.

Department of Biomedical Sciences, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy. Electronic address:

Ethnopharmacological Relevance: In spite of the rich bio-cultural diversity found in the Neotropics relatively few herbal drugs native to South-America are included in the global pharmacopoeia.

Material And Methods: In the attempt to historically explain the inclusion of herbal drugs into official pharmacopoeias we consider the disparate epidemiology and cultural evolution of the New and the Old World. We then trace the development of pharmacopoeias and review forces that worked towards and against the synchronization of pharmacopoeias and highlight the role of early chemical and pharmacological studies in Europe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.111891DOI Listing

Differential Expression of HMGA1 and HMGA2 in pituitary neuroendocrine tumors.

Mol Cell Endocrinol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Endocrinology - LEEx, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Graduate Program in Endocrinology, Faculty of Medicine, Federal University of Rio de Janeiro, Brazil; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil. Electronic address:

Defining biomarkers for invasive pituitary neuroendocrine tumors (PitNETs) is highly desirable. The high mobility group A (HMGA) proteins are among the most widely expressed cancer-associated proteins. Indeed, their overexpression is a frequent feature of human malignancies, including PitNETs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03037207193011
Publisher Site
http://dx.doi.org/10.1016/j.mce.2019.04.010DOI Listing
April 2019
1 Read

Fatty acid binding protein 4 (FABP4) as a potential biomarker reflecting myocardial lipid storage in type 2 diabetes.

Metabolism 2019 Apr 15. Epub 2019 Apr 15.

Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, "Sant Joan" University Hospital, Universitat Rovira i Virgili, Institut de Investigació Sanitaria Pere Virgili (IISPV), Reus, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Institute of Health Carlos III, Madrid, Spain. Electronic address:

Objective: Fatty acid binding protein 4 (FABP4) is an intracellular lipid chaperone involved in the crosstalk between adipose and peripheral tissues, and it contributes to widespread insulin resistance in cells, including cardiac cells. However, the role of this adipokine in regulating cardiac metabolism and myocardial neutral lipid content in patients with type 2 diabetes has not been elucidated.

Methods: The impact of circulating FABP4 on the cardiac neutral lipid content were measured by proton magnetic resonance spectroscopy (H-MRS) in patients with type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.metabol.2019.04.007DOI Listing

Anhedonia following mild traumatic brain injury in rats: A behavioral economic analysis of positive and negative reinforcement.

Behav Brain Res 2019 Apr 15:111913. Epub 2019 Apr 15.

NeuroBehavioral Research Lab, Department of Veteran Affairs Medical Center, New Jersey Health Care System, East Orange, New Jersey, USA; Department of Pharmacology, Physiology and Neurosciences, New Jersey Medical School - Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA; Graduate School of Biomedical Sciences, New Jersey Medical School-Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA. Electronic address:

Psychiatric disorders affect nearly 50% of individuals who have experienced a traumatic brain injury (TBI). Anhedonia is a major symptom of numerous psychiatric disorders and is a diagnostic criterion for depression. It has recently been appreciated that reinforcement may be separated into consummatory (hedonic), motivational and decisional components, all of which may be affected differently in disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01664328193034
Publisher Site
http://dx.doi.org/10.1016/j.bbr.2019.111913DOI Listing
April 2019
1 Read

Narrow-band Imaging for Detection of Neoplasia at Colonoscopy: a Meta-analysis of Data From Individual Patients in Randomized Controlled Trials.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK. Electronic address:

Background & Aims: Adenoma detection rate (ADR) is an important quality assurance measure for colonoscopy. Some studies suggest that narrow band imaging (NBI) may be more effective at detection of adenomas than white-light endoscopy (WLE) when bowel preparation is optimal. We conducted a meta-analysis of data from individual patients in randomized controlled trials that compared the efficacy of NBI to WLE in detection of adenomas. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
Publisher Site
http://dx.doi.org/10.1053/j.gastro.2019.04.014DOI Listing
April 2019
1 Read

IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
1 Read

Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.

J Mol Cell Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Cardiology Department, Clinic and Universitary Hospital Virgen de la Arrixaca, Murcia, Spain; CIBER in Cardiovascular Diseases (CIBERCV), Madrid, Spain.

Background: The cardioprotective effects of metformin remain poorly defined. Interleukin (IL)-33/ST2L signaling is a novel cardioprotective pathway, which is antagonized by the soluble isoform sST2. No data exist about the regulation of ST2 expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2019.04.009DOI Listing

Glyphaea brevis - In vitro antioxidant and in silico biological activity of major constituents and molecular docking analyses.

Toxicol In Vitro 2019 Apr 15. Epub 2019 Apr 15.

Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, PMB 704, The Federal University of Technology, Akure, Nigeria.

Previous studies have revealed that leaf extracts of Glyphaea brevis possess antioxidant activity but the bioactivity and mechanisms of action of its major constituents remain unknown. This study evaluated in vitro antioxidant and free radical scavenging activities of Glyphaea brevis twigs and leaves, and probable toxicity profile, pharmacological activities and mechanisms of action of major phytoconstituents in silico. Phytochemical screening detected saponins, tannins, steroids, anthraquinones, flavonoids, terpenoids and phenolics in the extracts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2019.04.013DOI Listing

On the critical evaluation and confirmation of germline sequence variants identified using massively parallel sequencing.

J Biotechnol 2019 Apr 15. Epub 2019 Apr 15.

Institute for Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia; Geneton Ltd., Bratislava, Slovakia. Electronic address:

Although massively parallel sequencing (MPS) is becoming common practice in both research and routine clinical care, confirmation requirements of identified DNA variants using alternative methods are still topics of debate. When evaluating variants directly from MPS data, different read depth statistics, together with specialized genotype quality scores are, therefore, of high relevance. Here we report results of our validation study performed in two different ways: 1) confirmation of MPS identified variants using Sanger sequencing; and 2) simultaneous Sanger and MPS analysis of exons of selected genes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
Publisher Site
http://dx.doi.org/10.1016/j.jbiotec.2019.04.013DOI Listing
April 2019
1 Read

Effect of benzalkonium chloride on dentin bond strength and endogenous enzymatic activity.

J Dent 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125 Bologna, Italy. Electronic address:

Objective: This in vitro study evaluated at baseline (T0) and over time (T12 months), the effect of a multi-mode universal adhesive compared with two experimental formulations blended with different concentrations of benzalkonium chloride (BAC), on bond strength and endogenous enzymatic activity.

Methods And Materials: Specimens were assigned to the following groups according to the adhesive protocol: G1) All-Bond Universal (ABU) self-etch (SE); G2) ABU + 0.5% BAC SE; G3) ABU + 1% methacrylate BAC SE; G4) ABU etch-and-rinse (E&R); G5) ABU + 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03005712193006
Publisher Site
http://dx.doi.org/10.1016/j.jdent.2019.04.008DOI Listing
April 2019
1 Read

Roles of K and Cation Channels in ORL-1 Receptor-mediated Depression of Neuronal Excitability and Epileptic Activities in the Medial Entorhinal Cortex.

Neuropharmacology 2019 Apr 15. Epub 2019 Apr 15.

From Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58203, USA. Electronic address:

Nociceptin (NOP) is an endogenous opioid-like peptide that selectively activates the opioid receptor-like (ORL-1) receptors. The entorhinal cortex (EC) is closely related to temporal lobe epilepsy and expresses high densities of ORL-1 receptors. However, the functions of NOP in the EC, especially in modulating the epileptiform activity in the EC, have not been determined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2019.04.017DOI Listing

Chronic Kidney Disease in Agricultural Communities.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Informatics, The Ohio State University. Electronic address:

Patients residing in agricultural communities have a high risk of developing chronic kidney disease. In the Great Plains, geo-environmental risk factors (variable climate, temperature, air quality, water quality and drought) combine with agro-environmental risk factors (exposure to fertilizers, soil conditioners, herbicides, fungicides and pesticides) to increase risk for toxic nephropathy. However, research defining the specific influence of agricultural chemicals on the progression of kidney disease in rural communities has been somewhat limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2019.03.036DOI Listing

Differential expression of androgen receptor variants in hormone-sensitive prostate cancer xenografts, castration-resistant sublines, and patient specimens according to the treatment sequence.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Androgen receptor variants (AR-vs), especially AR-v7 and AR-v 5, 6, and 7 exon-skipped (AR-v567es), are reportedly key players in the development of castration-resistant prostate cancer (CRPC). We previously established a mouse xenograft model (JDCaP) from a metastatic skin lesion from a Japanese patient with CRPC and that was revealed to exhibit androgen sensitivity. In the present study, we established multiple castration-resistant xenograft models from JDCaP mice to investigate the biological features of CRPC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.23816DOI Listing

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

PLoS Pathog 2019 Apr 18;15(4):e1007657. Epub 2019 Apr 18.

Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster, United Kingdom.

Helminths are highly prevalent metazoan parasites that infect over a billion of the world's population. Hosts have evolved numerous mechanisms to drive the expulsion of these parasites via Th2-driven immunity, but these responses must be tightly controlled to prevent equally devastating immunopathology. However, mechanisms that regulate this balance are still unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007657DOI Listing

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction.

PLoS Pathog 2019 Apr 18;15(4):e1007724. Epub 2019 Apr 18.

Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, ZA Leiden, The Netherlands.

Type 2 diabetes mellitus (DM) is a major risk factor for developing tuberculosis (TB). TB-DM comorbidity is expected to pose a serious future health problem due to the alarming rise in global DM incidence. At present, the causal underlying mechanisms linking DM and TB remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007724DOI Listing

Two components of the rhpPC operon coordinately regulate the type III secretion system and bacterial fitness in Pseudomonas savastanoi pv. phaseolicola.

PLoS Pathog 2019 Apr 18;15(4):e1007673. Epub 2019 Apr 18.

Guangdong Key Lab of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, China.

Many plant bacterial pathogens including Pseudomonas species, utilize the type III secretion system (T3SS) to deliver effector proteins into plant cells. Genes encoding the T3SS and its effectors are repressed in nutrient-rich media but are rapidly induced after the bacteria enter a plant or are transferred into nutrient-deficient media. To understand how the T3SS genes are regulated, we screened for P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007673DOI Listing

Prevalence of p53 dysregulations in feline oral squamous cell carcinoma and non-neoplastic oral mucosa.

PLoS One 2019 18;14(4):e0215621. Epub 2019 Apr 18.

Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Bologna, Italy.

Squamous cell carcinoma is the most common malignant oral tumor in cats. The late presentation is one of the factors contributing to the detrimental prognosis of this disease. The immunohistochemical expression of the p53 tumor suppressor protein has been reported in 24% to 65% of feline oral squamous cell carcinomas, but no study has systematically evaluated in this tumor the presence of p53 encoding gene (TP53) mutations. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215621PLOS

SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species.

PLoS Comput Biol 2019 Apr 18;15(4):e1006968. Epub 2019 Apr 18.

Department of Computer Science, ETH Zurich, Zürich, Switzerland.

Understanding sleep and its perturbation by environment, mutation, or medication remains a central problem in biomedical research. Its examination in animal models rests on brain state analysis via classification of electroencephalographic (EEG) signatures. Traditionally, these states are classified by trained human experts by visual inspection of raw EEG recordings, which is a laborious task prone to inter-individual variability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006968DOI Listing

Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients.

PLoS One 2019 18;14(4):e0214604. Epub 2019 Apr 18.

Ingham Institute for Applied Medical Research, Liverpool, NSW Australia.

Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 and DCR2 and assesses their significance on patient survival as a single or combined marker with P16 or P14 using breast cancer progression series. One thousand and eighty (1080) patients with primary invasive ductal carcinoma, no special type, were recruited through an 11-year retrospective study period. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214604PLOS

What Is the Impact of a Previous Femoral Osteotomy on THA? A Systematic Review.

Clin Orthop Relat Res 2019 May;477(5):1176-1187

E. Gallazzi, L. Zagra, IRCCS Istituto Ortopedico Galeazzi, Hip Department, vi R. Galeazzi, Milan, Italy I. Morelli, G. Peretti, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy IRCCS Istituto Ortopedico Galeazzi, via R. Galeazzi Milan, Italy.

Background: Femoral osteotomies have been widely used to treat a wide range of developmental and degenerative hip diseases. For this purpose, different types of proximal femur osteotomies were developed: at the neck as well as at the trochanteric, intertrochanteric, or subtrochanteric levels. Few studies have evaluated the impact of a previous femoral osteotomy on a THA; thus, whether and how a previous femoral osteotomy affects the outcome of THA remains controversial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CORR.0000000000000659DOI Listing

A Feasibility Study to Attribute Patients to Primary Interns on Inpatient Ward Teams Using Electronic Health Record Data.

Acad Med 2019 Apr 16. Epub 2019 Apr 16.

D.J. Schumacher is associate professor of pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. D.T.Y. Wu is assistant professor of biomedical informatics and pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. K. Meganathan is senior clinical data analyst, Center for Health Informatics, University of Cincinnati College of Medicine, Cincinnati, Ohio. L. Li is research associate, Center for Health Informatics, University of Cincinnati College of Medicine, Cincinnati, Ohio. B. Kinnear is assistant professor of pediatrics and internal medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. D.R. Sall is assistant professor of internal medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. E. Holmboe is senior vice president for milestones development and evaluation, Accreditation Council for Graduate Medical Education, Chicago, Illinois. C. Carraccio is vice president of competency-based assessment, American Board of Pediatrics, Chapel Hill, North Carolina. C. van der Vleuten is professor of education, Department of Educational Development and Research, Faculty of Health, Medicine, and Life Sciences; and scientific director, School of Health Professions Education (SHE), Maastricht University, Maastricht, The Netherlands. J. Busari is consultant pediatrician and associate professor of medical education, Maastricht University, Maastricht, The Netherlands. M. Kelleher is assistant professor of pediatrics and internal medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. D. Schauer is associate professor of internal medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. E. Warm is professor of medicine and internal medicine program director, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Purpose: To inform graduate medical education (GME) outcomes at the individual resident level, this study sought a method for attributing care for individual patients to individual interns based on "footprints" in the electronic health record (EHR).

Method: Primary interns caring for patients on an internal medicine inpatient service were recorded daily by five attending physicians of record at University of Cincinnati Medical Center in August 2017 and January 2018. These records were considered gold standard identification of primary interns. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00001888-900000000-9761
Publisher Site
http://dx.doi.org/10.1097/ACM.0000000000002748DOI Listing
April 2019
1 Read

The Cost-Effectiveness of Bimodal Stimulation Compared to Unilateral and Bilateral Cochlear Implant Use in Adults with Bilateral Severe to Profound Deafness.

Ear Hear 2019 Apr 10. Epub 2019 Apr 10.

National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Queens Medical Centre, Nottingham, United Kingdom.

Objectives: An increasing number of severe-profoundly deaf adult unilateral cochlear implant (CI) users receive bimodal stimulation; that is, they use a conventional acoustic hearing aid (HA) in their nonimplanted ear. The combination of electric and contralateral acoustic hearing provides additional benefits to hearing and also to general health-related quality of life compared with unilateral CI use. Bilateral CI is a treatment alternative to both unilateral CI and bimodal stimulation in some healthcare systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/AUD.0000000000000727DOI Listing

The Panacea of Human Aging: Calorie Restriction Versus Exercise.

Exerc Sport Sci Rev 2019 Apr 15. Epub 2019 Apr 15.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808.

Primary aging is the progressive decline in health and fitness and depends on metabolic rate and oxidative stress. Untoward changes in body composition and metabolic function characterizes secondary aging. We hypothesize that both exercise and calorie restriction improve secondary aging, but only calorie restriction improves primary. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00003677-900000000-9974
Publisher Site
http://dx.doi.org/10.1249/JES.0000000000000193DOI Listing
April 2019
1 Read

Prospective Respiration-Gated Photoacoustic Microscopy.

IEEE Trans Biomed Eng 2019 Apr 16. Epub 2019 Apr 16.

Objective: Photoacoustic microscopy (PAM) is a promising biomedical imaging technique that relies on sequential excitation to generate three-dimensional images. It combines the high contrast of optical imaging with high penetration depth of ultrasound imaging. The normal respiration rate of mice is greater than 3 Hz, which leads to motion artifacts in most reported PAM for in-vivo imaging. Read More

View Article

Download full-text PDF

Source
https://ieeexplore.ieee.org/document/8692629/
Publisher Site
http://dx.doi.org/10.1109/TBME.2019.2911551DOI Listing
April 2019
1 Read

An update on heart disease risk associated with testosterone boosting medications.

Expert Opin Drug Saf 2019 Apr 18. Epub 2019 Apr 18.

b Andrology, Female Endocrinology and Gender Incongruence Unit, Department of Experimental, Clinical and Biomedical Sciences , University of Florence , Florence , Italy.

Introduction: The cardiovascular (CV) safety of testosterone replacement therapy (TRT) remains a crucial issue in the management of subjects with late onset hypogonadism. The authors systematically reviewed and discussed the available evidence focusing our analysis on heart related issues. Areas covered: All the available data from prospective observational studies evaluating the role endogenous T levels on the risk of acute myocardial infarction (AMI) were collected and analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14740338.2019.1607290DOI Listing

Heart Transplantation With Donation After Circulatory Death.

Circ Heart Fail 2019 Apr;12(4):e005517

Department of Cardiovascular Surgery, Inselspital, Bern University Hospital and Department for BioMedical Research, University of Bern, Switzerland (P.N., E.F., M.D., T.P.C., H.T.T.S., S.L.L.).

Heart transplantation remains the preferred option for improving quality of life and survival for patients suffering from end-stage heart failure. Unfortunately, insufficient supply of cardiac grafts has become an obstacle. Increasing organ availability with donation after circulatory death (DCD) may be a promising option to overcome the organ shortage. Read More

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
Publisher Site
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005517DOI Listing
April 2019
1 Read

Sacubitril/Valsartan Decreases Cardiac Fibrosis in Left Ventricle Pressure Overload by Restoring PKG Signaling in Cardiac Fibroblasts.

Circ Heart Fail 2019 Apr;12(4):e005565

Department of Medicine, Aab Cardiovascular Research Institute (R.M.B., J.K.L., D.M.M., E.M.S.), University of Rochester, NY.

Background Heart failure (HF) is invariably accompanied by development of cardiac fibrosis, a form of scarring that increases muscular tissue rigidity and decreases cardiac contractility. Cardiac fibrosis arises from a pathological attempt to repair tissue damaged during maladaptive remodeling. Treatment options to block or reverse fibrosis have proven elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005565DOI Listing

Nanogels and microgels: From model colloids to applications, recent developments and future trends.

Langmuir 2019 Apr 18. Epub 2019 Apr 18.

Nanogels and microgels are soft, deformable and penetrable objects with an internal gel-like structure that is swollen by the dispersing solvent. Their softness and the potential to respond to external stimuli like temperature, pressure, pH, ionic strength and different analytes make them interesting as soft model systems in fundamental research as well as for a broad range of applications, in particular in the field of biological applications. Recent tremendous developments in their synthesis open access to systems with complex architectures and compositions allowing for tailoring microgels with specific properties. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.langmuir.8b04304
Publisher Site
http://dx.doi.org/10.1021/acs.langmuir.8b04304DOI Listing
April 2019
1 Read

Nanoscale Metal-Organic Framework Hierarchically Combines High-Z Components for Multifarious Radio-enhancement.

J Am Chem Soc 2019 Apr 18. Epub 2019 Apr 18.

With tunability and porosity, nanoscale metal-organic frameworks (nMOFs) can incorporate multiple components to realize complex functions for biomedical applications. Here we report the synthesis of W@Hf-DBB-Ir, a new nMOF assembly hierarchically incorporating three high-Z components -- Hf-based metal-oxo clusters, Ir-based bridging ligands, and W-based polyoxometalates (POMs) -- as a multifarious radioenhancer. Cationic Hf-DBB-Ir was built from Hf secondary building units (SBUs) and [Ir(bpy)(ppy)] (bpy = 2,2'-bipyridine, ppy = 2-phenylpyridine) derived dicarboxylate ligands (DBB-Ir) and then loaded with Wells-Dawson-type [PWO] (W) POMs to afford W@Hf-DBB-Ir. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.9b03029DOI Listing

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles.

ACS Nano 2019 Apr 18. Epub 2019 Apr 18.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity , The University of Melbourne , Parkville , Victoria 3010 , Australia.

Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation of a biomolecular corona. This corona modulates downstream biological responses, including recognition by and association with human immune cells. Considerable research effort has been directed toward the design of materials that can demonstrate a low affinity for various proteins (low-fouling materials) and materials that can exhibit low association with human immune cells (stealth materials). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.9b00552DOI Listing

Effect of Specialized Critical Care Transport Unit on Short-Term Mortality of Critically Ill Patients Undergoing Interhospital Transport.

Prehosp Emerg Care 2019 Apr 18:1-13. Epub 2019 Apr 18.

f Seoul National University Hospital , Jongno-gu , 110-744 Korea.

Objective To minimize risk and prevent harmful incidents during interhospital transport, the critical care transport unit service called Seoul Mobile Intensive Care Unit (SMICU) was organized and initiated its service within the city of Seoul. We sought to evaluate the effectiveness of critical care transport units on outcomes of critically ill patients undergoing interhospital transport in Seoul Methods A retrospective observational case-control study was designed to evaluate the effectiveness of critical care transport units on outcomes of critically ill patients undergoing interhospital transport. ED patients transported from other hospitals in Seoul during 2016 were identified in the National Emergency Department Information System (NEDIS) and according to use of SMICU. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/10903127.2019.1
Publisher Site
http://dx.doi.org/10.1080/10903127.2019.1607959DOI Listing
April 2019
1 Read

Pedagogical training profile of basic health sciences faculty in biomedical and related fields at Brazilian public and private higher education institutions.

Adv Physiol Educ 2019 Jun;43(2):180-190

Graduate Program in Biological Sciences: Physiology, Federal University of Rio Grande do Sul , Porto Alegre, Rio Grande do Sul , Brazil.

Historically, Brazilian higher education teachers' pedagogical training has not been a concern. Even today, a graduate degree is the main requirement to be a faculty member. However, a set of competencies is necessary to teach: pedagogical competency, political competency, and knowledge of specific content. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/advan.00211.2018DOI Listing

CRISPR-Cas9-Mediated Correction of the G189R-PAX2 Mutation in Induced Pluripotent Stem Cells from a Patient with Focal Segmental Glomerulosclerosis.

CRISPR J 2019 Apr;2:108-120

1 Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy; University of Milan, Milan, Italy.

Focal segmental glomerulosclerosis (FSGS) is defined by focal (involving few glomeruli) and segmental sclerosis of the glomerular tuft that manifests with nephrotic syndrome. Mutations in genes involved in the maintenance of structure and function of podocytes have been found in a minority of these patients. A family with adult-onset autosomal dominant FSGS was recently found to carry a new germline missense heterozygous mutation (p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/crispr.2018.0048DOI Listing

Dry skin management: Practical approach in light of latest research on skin structure and function.

J Dermatolog Treat 2019 Apr 18:1-28. Epub 2019 Apr 18.

e Leiden Academic Centre for Drug Research, Division of Drug Delivery Technology , Leiden , PO box 9502, NL-2300 RA Leiden , The Netherlands.

Dry skin is a common condition that is attributed to a lack of water in the stratum corneum. With the availability of new technologies, light has been shed on the pathophysiology of dry skin at the molecular level. With the aim to discuss implications of this latest research for the optimal formulation of emollients designed to treat dry skin, five specialists met in November 2017. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
Publisher Site
http://dx.doi.org/10.1080/09546634.2019.1607024DOI Listing
April 2019
1 Read

Genetics Guideline Is Excellent, but the Pharmacogenetics Section Is Weak.

Authors:
Jose de Leon

J Clin Psychiatry 2019 Apr 9(3). Epub 2019 Apr 9.

Mental Health Research Center at Eastern State Hospital, Lexington, Kentucky, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4088/JCP.19lr12741DOI Listing

Toxicology in the Super-Resolution Era.

Authors:
Richard Cole

Curr Protoc Toxicol 2019 Apr 18:e77. Epub 2019 Apr 18.

Wadsworth Center, New York State Department of Health, Albany, New York.

Light microscopy has played a central role in science for the past couple of hundred years and will continue to do so. Multiple super-resolution microscopy techniques have been in the headlines for smashing what for more than 100+ years was believed to be the limits of optical microscopy. This resolution improvement enables the visualization of molecular structures and processes on the nano scale. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cptx.77DOI Listing

Bacterial community structure and function distinguish gut sites in captive red-shanked doucs (Pygathrix nemaeus).

Am J Primatol 2019 Apr 18:e22977. Epub 2019 Apr 18.

Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota.

The mammalian order primates contains wide species diversity. Members of the subfamily Colobinae are unique amongst extant primates in that their gastrointestinal systems more closely resemble those of ruminants than other members of the primate order. In the growing literature surrounding nonhuman primate microbiomes, analysis of microbial communities has been limited to the hindgut, since few studies have captured data on other gut sites, including the foregut of colobine primates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajp.22977DOI Listing

Wash-in/wash-out phase xenon-enhanced area-detector CT (ADCT): utility for regional ventilation, pulmonary functional loss and clinical stage evaluations of smokers.

Acta Radiol 2019 Apr 18:284185119840647. Epub 2019 Apr 18.

1 Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Xenon (Xe)-enhanced area-detector computed tomography (ADCT) can visualize regional distribution of Xe within the lungs and demonstrate regional ventilation differences in smokers and patients with pulmonary diseases.

Purpose: The purpose of this study was to evaluate the capability of wash-in and wash-out (WI/WO) phase Xe-enhanced ADCT for detecting regional ventilation differences based on underlying lung conditions, pulmonary functional loss evaluation, and clinical stage prediction for smokers with and without chronic obstructive pulmonary disease (COPD).

Material And Methods: The pulmonary function test as well as inspiratory/expiratory unenhanced and WI/WO phase Xe-enhanced ADCT were prospectively administered to a group of 40 smokers consisting of 25 men (mean age ± standard deviation [SD] = 65. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0284185119840647
Publisher Site
http://dx.doi.org/10.1177/0284185119840647DOI Listing
April 2019
1 Read

Surface Charge-Reversible Tubular Micromotors for Extraction of Nucleic Acids in Microsystems.

Chem Asian J 2019 Apr 17. Epub 2019 Apr 17.

Wuhan University of Technology, 122 Luoshi road, Wuhan, CHINA.

Extraction of nucleic acids in microsystems is of significance for biomedical applications, but the current extraction methods generally require sophisticated microchannels and external equipment, hindering their practical applications. In this work, we have demonstrated a simple, versatile and efficient approach to extract nucleic acids in microsystems by developing cationic branched polyethyleneimine (PEI)-functionalized tubular micromotors. The as-developed tubular micromotors are fabricated by a two-step process combining the template-assisted electrodeposition and carbodiimide chemistry, and contain an inner catalytic Pt layer, a middle magnetic Ni layer and an outer cationic PEI layer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/asia.201900427DOI Listing

Senescence as a main mechanism of Ritonavir and Ritonavir-NO action against melanoma.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Immunology, Institute for Biological Research "Siniša Stanković", Belgrade University, Belgrade, Serbia.

The main focus of this study is exploring the effect and mechanism of two HIV-protease inhibitors: Ritonavir and Ritonavir-nitric oxide (Ritonavir-NO) on in vitro growth of melanoma cell lines. NO modification significantly improved the antitumor potential of Ritonavir, as the IC values of Ritonavir-NO were approximately two times lower than IC values of the parental compound. Our results showed for the first time, that both compounds induced senescence in primary and metastatic melanoma cell lines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mc.23020DOI Listing
April 2019
1 Read
  • Page 1 of 11477