669,104 results match your criteria Biomedical Papers-olomouc[Journal]


Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.

Diabet Med 2020 Jul 7. Epub 2020 Jul 7.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.

Aim: Misclassification of diabetes is common due to an overlap in the clinical features of type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and biomarker information have recently been developed that can aid classification, but they have not been validated using pancreatic pathology. We evaluated a clinical diagnostic model against histologically defined type 1 diabetes. Read More

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http://dx.doi.org/10.1111/dme.14361DOI Listing

Diabetes treatment in two pregnant women with permanent neonatal diabetes mellitus due to a KCNJ11 mutation.

Diabet Med 2020 Jul 7. Epub 2020 Jul 7.

DIABGENE Laboratory, Institute of Experimental Endocrinology, Biomedical Research Centre of Slovak Academy of Sciences, Bratislava, Slovakia.

Heterozygous activating KCNJ11 mutations are a common cause of permanent neonatal diabetes mellitus (PNDM) treated with insulin or sulfonylureas. However, only a few case reports on the treatment of women with KCNJ11-PNDM during pregnancy have been published. In the present paper, we report on two women with PNDM carrying a de novo heterozygous activating KCNJ11 mutation who were treated with a sulfonylurea and/or insulin during their pregnancies. Read More

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http://dx.doi.org/10.1111/dme.14363DOI Listing

International Consensus Statement for the Screening, Diagnosis, and Treatment of Adolescents with Concurrent Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder.

Eur Addict Res 2020 Jul 7:1-10. Epub 2020 Jul 7.

Parnassia Addiction Research Centre (PARC), Parnassia Psychiatric Institute, The Hague, The Netherlands.

Background: Childhood attention-deficit/hyperactivity disorder (ADHD) is a risk factor for substance misuse and substance use disorder (SUD) in adolescence and (early) adulthood. ADHD and SUD also frequently co-occur in treatment-seeking adolescents, which complicates diagnosis and treatment and is associated with poor treatment outcomes. Research on the effect of treatment of childhood ADHD on the prevention of adolescent SUD is inconclusive, and studies on the diagnosis and treatment of adolescents with ADHD and SUD are scarce. Read More

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http://dx.doi.org/10.1159/000508385DOI Listing

Effect of dose-dense adjuvant chemotherapy in hormone receptor positive/HER2-negative early breast cancer patients according to immunohistochemically defined luminal subtype: an exploratory analysis of the GIM2 trial.

Eur J Cancer 2020 Jul 4;136:43-51. Epub 2020 Jul 4.

Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genova, Viale Benedetto XV, 10, 16132, Genoa, GE, Italy; Breast Unit, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, GE, Italy. Electronic address:

Background: Luminal A-like and luminal B-like subtypes have different sensitivity to (neo)adjuvant chemotherapy, but their role in predicting dose-dense (DD) efficacy in the high-risk setting is unknown. In this exploratory analysis of the Gruppo Italiano Mammella 2 (GIM2) trial, we investigated DD efficacy according to luminal-like subtypes.

Methods: Patients with node-positive early breast cancer were randomised to receive either DD or standard-interval (SI) anthracycline-based chemotherapy followed by paclitaxel. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.05.007DOI Listing

Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-κB pathway.

Int Immunopharmacol 2020 Jul 4;86:106751. Epub 2020 Jul 4.

Dermatology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, Shaanxi 710004, China. Electronic address:

Saikosaponin A (SSA) is a triterpenoid saponin extracted from oriental medicinal plant Radix bupleuri, possessing various biological functions such as anti-inflammatory, immune regulation and anti-virus. This study aimed to explore therapeutic effects of SSA on psoriasis in both vitro and vivo. Our results showed that SSA increased reactive oxygen species (ROS) generation, and decreased mitochondrial membrane potential (MMP) and M5-induced inflammatory cytokines levels in HEKa cells in a dose-dependent manner. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106751DOI Listing

Visible Light Plasmon Excitation of Silver Nanoparticles Against Antibiotic-Resistant Pseudomonas aeruginosa.

Photodiagnosis Photodyn Ther 2020 Jul 4:101908. Epub 2020 Jul 4.

Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Brazil. Electronic address:

The interaction of metallic nanoparticles with light excites a local surface plasmon resonance (LSPR). This phenomenon enables the transfer of hot electrons to substrates that release Reactive Oxygen Species (ROS). In this context, the present study aimed at enhancing the antibacterial effect of citrate-covered silver nanoparticles (AgNPs) by LSPR excitation with visible LED. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101908DOI Listing

Interactive thyroid whole slide image diagnostic system using deep representation.

Comput Methods Programs Biomed 2020 Jun 27;195:105630. Epub 2020 Jun 27.

Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, United States.

Background And Objectives: The vast size of the histopathology whole slide image poses formidable challenges to its automatic diagnosis. With the goal of computer-aided diagnosis and the insights that suspicious regions are generally easy to identify in thyroid whole slide images (WSIs), we develop an interactive whole slide diagnostic system for thyroid frozen sections based on the suspicious regions preselected by pathologists.

Methods: We propose to generate feature representations for the suspicious regions via extracting and fusing patch features using deep neural networks. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105630DOI Listing

Performance evaluation of the spectral autocorrelation function and autoregressive models for automated sleep apnea detection using single-lead ECG signal.

Comput Methods Programs Biomed 2020 Jun 26;195:105626. Epub 2020 Jun 26.

Department of Biomedical Engineering, Tarbiat Modares University, Tehran, Iran. Electronic address:

Background And Objective: This paper addresses the automated recognition of obstructive sleep apnea (OSA) from the analysis of single-lead ECG signals. This is one of the most important problems that is, critical to the realization of monitoring patients with sleep apnea.

Methods: In the present study, a novel solution based on autoregressive (AR) modeling of the single-lead ECG, and spectral autocorrelation function as an ECG feature extraction method is presented. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105626DOI Listing

Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential.

Eur J Med Chem 2020 Jul 2;202:112603. Epub 2020 Jul 2.

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai, Maharashtra, India. Electronic address:

Cancer cells increase their glucose uptake and glycolytic activity to meet the high energy requirements of proliferation. Glucose transporters (GLUTs), which facilitate the transport of glucose and related hexoses across the cell membrane, play a vital role in tumor cell survival and are overexpressed in various cancers. GLUT1, the most overexpressed GLUT in many cancers, is emerging as a promising anti-cancer target. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112603DOI Listing

The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes.

Public Health 2020 Jul 4;185:153-158. Epub 2020 Jul 4.

Institute for Clinical and Experimental Medicine, Department of Gastroenterology and Hepatology, Prague, Czech Republic.

Objectives: Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation.

Study Design: The aim of our national multicentre prospective observational study was to reveal and document clinicopathological differences in CRC diagnosed by screening and presented by disease symptoms as well as assess the efficiency of the screening programme in the Czech Republic. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.05.021DOI Listing

Quantification of brain oxygen extraction and metabolism with [O]-gas PET: A technical review in the era of PET/MRI.

Neuroimage 2020 Jul 4:117136. Epub 2020 Jul 4.

Department of Radiology, Stanford University, Stanford CA, USA.

Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO) are key cerebral physiological parameters to identify at-risk cerebrovascular patients and understand brain health and function. PET imaging with [O]-oxygen tracers, either through continuous or bolus inhalation, provides non-invasive assessment of OEF and CMRO. Numerous tracer delivery, PET acquisition, and kinetic modeling approaches have been adopted to map brain oxygenation. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117136DOI Listing

Neuroimaging and electrophysiology meet invasive neurostimulation for causal interrogations and modulations of brain states.

Neuroimage 2020 Jul 4:117144. Epub 2020 Jul 4.

Movement Disorders and Neurostimulation, Biomedical Statistics and Multimodal Signal Processing Unit, Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Germany. Electronic address:

Deep brain stimulation (DBS) has developed over the last twenty years into a highly effective evidenced-based treatment option for neuropsychiatric disorders. Moreover, it has become a fascinating tool to provide illustrative insights into the functioning of brain networks. New anatomical and pathophysiological models of DBS action have accelerated our understanding of neurological and psychiatric disorders and brain functioning. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117144DOI Listing

IL-10-producing NK cells exacerbate sublethal Streptococcus pneumoniae infection in the lung.

Transl Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Biomedical Sciences, National Jewish Health, Denver, CO, United States of America; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, United States of America. Electronic address:

Lung inflammation is tightly controlled to balance microbial clearance with the tissue damage that accompanies this response. Bacterial pathogens including Streptococcus pneumoniae modulate immune regulation by promoting secretion of the anti-inflammatory cytokine IL-10. The important cellular sources of IL-10 that impact protection against different bacterial infections are not well characterized. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.07.001DOI Listing

Mechanistic understanding of salt-induced drug encapsulation in nanosuspension via acid-base neutralization as a nanonization platform technology to enhance dissolution rate of pH-dependent poorly water-soluble drugs.

Eur J Pharm Biopharm 2020 Jul 4. Epub 2020 Jul 4.

College of Pharmacy, Ajou University, Suwon 443-749, Republic of Korea; Institute of Pharmaceutical Science and Technology, Ajou University, Suwon 16499, Republic of Korea. Electronic address:

An acid-base neutralization technique has generated interest for the ability to achieve an enhanced dissolution of pH-dependent weakly basic or acidic poorly water-soluble drugs. However, the underlying nanonization mechanism, following acid-base neutralization, requires further elucidation. We hypothesized that the nanosuspensions (NSPs) via nanonization of drug particles could be attributed to the "salt-induced effect" and surfactant-driven micellization after acid-base neutralization. Read More

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http://dx.doi.org/10.1016/j.ejpb.2020.07.001DOI Listing

Functional Imaging using Radiomic Features in Assessment of Lymphoma.

Methods 2020 Jul 4. Epub 2020 Jul 4.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.

Lymphomas are typically large, well-defined, and relatively homogeneous tumors, and therefore represent ideal targets for the use of radiomics. Of the available functional imaging tests, [18F]FDG-PET for body lymphoma and diffusion-weighted MRI (DWI) for central nervous system (CNS) lymphoma are of particular interest. The current literature suggests that two main applications for radiomics in lymphoma show promise: differentiation of lymphomas from other tumors, and lymphoma treatment response and outcome prognostication. Read More

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http://dx.doi.org/10.1016/j.ymeth.2020.06.020DOI Listing

Machine segmentation of pelvic anatomy in MRI-assisted radiosurgery (MARS) for prostate cancer brachytherapy.

Int J Radiat Oncol Biol Phys 2020 Jul 4. Epub 2020 Jul 4.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1422, Houston, TX 77030.

Purpose: To investigate machine segmentation of pelvic anatomy in MRI-assisted radiosurgery (MARS) for prostate cancer using prostate brachytherapy MRIs acquired with different pulse sequences and image contrasts.

Methods: Two hundred 3D pre- and post-implant prostate brachytherapy MRIs were acquired with a T2w sequence, a T2/T1w sequence, or a T1w sequence. One hundred twenty DL models were trained to segment the prostate, seminal vesicles (SV), external urinary sphincter (EUS), rectum, and bladder using the MRIs acquired with T2w and T2/T1w image contrast. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.076DOI Listing

RIFM fragrance ingredient safety assessment, 1-(2-methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol, CAS Registry Number 526218-21-3.

Food Chem Toxicol 2020 Jul 4:111492. Epub 2020 Jul 4.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677,, USA.

The existing information supports the use of this material as described in this safety assessment. 1-(2-Methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 1-(2-methylprop-2-enoloxy)-2,2,4-trimethylpentan-3-ol is not genotoxic. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111492DOI Listing

RIFM fragrance ingredient safety assessment, 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile, CAS registry number 68084-04-8.

Food Chem Toxicol 2020 Jul 4:111491. Epub 2020 Jul 4.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

The existing information supports the use of this material as described in this safety assessment. 3-(4-Methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile is not genotoxic. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111491DOI Listing

Focal adhesion displacement magnitude is a unifying feature of tensional homeostasis.

Acta Biomater 2020 Jul 4. Epub 2020 Jul 4.

Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts, 02215. Electronic address:

Tensional homeostasis is widely recognized to exist at the length scales of organs and tissues, but the cellular length scale mechanism for tension regulation is not known. In this study, we explored whether tensional homeostasis emerges from the behavior of the individual focal adhesion (FA), which is the subcellular structure that transmits cell stress to the surrounding extracellular matrix. Past studies have suggested that cell contractility builds up until a certain displacement is achieved, and we thus hypothesized that tensional homeostasis may require a threshold level of substrate displacement. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.043DOI Listing

Polypeptide-Based Self-Healing Hydrogels: Design and Biomedical Applications.

Acta Biomater 2020 Jul 4. Epub 2020 Jul 4.

School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China; Sino-Singapore International Joint Research Institute, Guangzhou, 510555, China. Electronic address:

Self-healing hydrogels can heal themselves on the damaged sites, which opens up a fascinating way for enhancing lifetimes of materials. Polypeptide/poly(amino acid) is a class of polymers in which natural amino acid monomers or derivatives are linked by amide bonds with a stable and similar secondary structure as natural proteins (α-helix or β-fold). They have the advantages of nontoxicity, biodegradability, and low immunogenicity as well as easy modification. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.001DOI Listing

Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.

Eur J Pharmacol 2020 Jul 4:173340. Epub 2020 Jul 4.

Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH, 45701, USA; Biomedical Engineering Program, Ohio University, Athens, OH, 45701, USA. Electronic address:

Sepsis is a serious condition that can lead to long-term organ damage and death. At the molecular level, the hallmark of sepsis is the elevated expression of a multitude of potent cytokines, i.e. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173340DOI Listing

Potential roles of PP2A-Rac1 signaling axis in pancreatic β-cell dysfunction under metabolic stress: Progress and Promise.

Biochem Pharmacol 2020 Jul 4:114138. Epub 2020 Jul 4.

Biomedical Laboratory Research Service, John D. Dingell VA Medical Center and Departments of Pharmaceutical Sciences and Internal Medicine, Wayne State University, Detroit, MI 48201, United States. Electronic address:

Recent estimates by the International Diabetes Federation suggest that the incidence of diabetes soared to an all-time high of 463 million in 2019, and the federation predicts that by 2045 the number of individuals afflicted with this disease will increase to 700 million. Therefore, efforts to understand the pathophysiology of diabetes are critical for moving toward the development of novel therapeutic strategies for this disease. Several contributors (oxidative stress, endoplasmic reticulum stress and others) have been proposed for the onset of metabolic dysfunction and demise of the islet β-cell leading to the pathogenesis of diabetes. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114138DOI Listing

Overexpression of ABCB1 and ABCG2 contributes to reduced efficacy of the PI3K/mTOR inhibitor samotolisib (LY3023414) in cancer cell lines.

Biochem Pharmacol 2020 Jul 4:114137. Epub 2020 Jul 4.

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.

LY3023414 (samotolisib) is a promising new dual inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Currently, multiple clinical trials are underway to evaluate the efficacy of LY3023414 in patients with various types of cancer. However, the potential mechanisms underlying acquired resistance to LY3023414 in human cancer cells still remain elusive. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114137DOI Listing

Cell Division: Interkinetic Nuclear… Mechanics.

Curr Biol 2020 Jul;30(13):R759-R761

Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627, USA; Department of Biology, University of Rochester, Rochester, NY 14627, USA; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14627, USA. Electronic address:

New work reveals that interkinetic nuclear migration - the movement of nuclei towards the apical surface of dividing epithelial cells - is mechanically regulated, relying on a balance of forces between the mitotic cell and the surrounding tissue. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.028DOI Listing

Use of Automated Office Blood Pressure Measurement in the Evaluation of Elevated Blood Pressures in Children and Adolescents.

J Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Professor of Pediatrics, University of Washington School of Medicine, Division of Nephrology, Seattle Children's Hospital.

Objectives: To determine the level of agreement between AOBP, auscultated or manual office BP (MOBP) and 24 hour ABPM, and to explore the ability of AOBP and MOBP to correctly identify daytime ambulatory hypertension (HTN) in children.

Study Design: We retrospectively compared BPs obtained by AOBP and MOBP to predict daytime HTN on ABPM. Six BPs were taken by AOBP followed by MOBP. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.059DOI Listing

Core regulatory circuitries in defining cancer cell identity across the malignant spectrum.

Open Biol 2020 Jul 8;10(7):200121. Epub 2020 Jul 8.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA.

Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engage super-enhancers by recruiting acetylation writers depositing permissive H3K27ac chromatin marks. These super-enhancers are largely associated with BET proteins, including BRD4, that influence higher-order chromatin structure. Read More

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http://dx.doi.org/10.1098/rsob.200121DOI Listing

Multidisciplinary approaches to the management of malignant pleural effusions: a guide for the clinician.

Expert Rev Respir Med 2020 Jul 7. Epub 2020 Jul 7.

Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Trust , Oxford, UK.

Introduction: Malignant pleural effusion (MPE) is a complication of advanced cancer, associated with significant mortality and morbidity. This entity is commonly treated by respiratory physicians, oncologists and thoracic surgeons. There have been various randomised clinical trials assessing the relative merits of chest drain pleurodesis, indwelling pleural catheters, treatment of septated MPEs, the use of thoracoscopy and pleurodesis and pleurodesis through IPCs in the past decade which have addressed some key areas in the management of MPEs, with an increasing focus on patient related outcome. Read More

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http://dx.doi.org/10.1080/17476348.2020.1793672DOI Listing

Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.

J Med Chem 2020 Jul 7. Epub 2020 Jul 7.

Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.

Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance, driven largely by target-based mutations in the GyrA/ParC quinolone resistance determining region, have eroded the utility and threaten the future use of this vital class of antibiotics. Herein we describe the discovery and optimization of a series of 4-(aminomethyl)quinolin-2(1)-ones, exemplified by , that inhibit bacterial DNA gyrase and topoisomerase IV and display potent activity against ciprofloxacin-resistant Gram-negative pathogens. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.0c00347DOI Listing

Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.

Am J Hypertens 2020 Jul 7. Epub 2020 Jul 7.

Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: Aortic stiffness as measured by carotid-femoral pulse wave velocity (cfPWV) is known to depend on blood pressure (BP), and this dependency may change with age. Therefore, the hydrostatic BP gradient resulting from a change in body posture may elicit a cfPWV change that is age-dependent. We aimed to analyze the relationship between BP gradient - induced by head-up body tilting - and related changes in cfPWV in individuals of varying age. Read More

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http://dx.doi.org/10.1093/ajh/hpaa101DOI Listing

Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML.

Blood Adv 2020 Jul;4(13):3109-3122

Division of Pediatric Oncology, Department of Pediatrics, Center for Childhood Cancer Research and.

Understanding mechanisms of cooperation between oncogenes is critical for the development of novel therapies and rational combinations. Acute myeloid leukemia (AML) cells with KMT2A-fusions and KMT2A partial tandem duplications (KMT2APTD) are known to depend on the histone methyltransferase DOT1L, which methylates histone 3 lysine 79 (H3K79). About 30% of KMT2APTD AMLs carry mutations in IDH1/2 (mIDH1/2). Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001922DOI Listing

Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer.

PLoS One 2020 7;15(7):e0235613. Epub 2020 Jul 7.

Department of Medical Genetics, St. Olavs Hospital, Trondheim, Norway.

Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification of these pathogenic variants is important to identify endometrial cancer patients with inherited increased risk of new cancers, in order to offer them lifesaving surveillance. However, several other genes are also part of the MMR pathway. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235613PLOS

Proximal renal tubular function in HIV-infected children on tenofovir disoproxil fumarate for treatment of HIV infection at two tertiary hospitals in Harare, Zimbabwe.

PLoS One 2020 7;15(7):e0235759. Epub 2020 Jul 7.

Department of Paediatrics, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.

Background: Renal abnormalities in HIV infected children may be due to the HIV infection or treatment among other factors. Tenofovir disoproxil fumarate (TDF) is associated with proximal renal tubular dysfunction, proteinuria and decrease in glomerular function. Studies in developed countries have shown variable prevalence of proximal renal tubular dysfunction in children on TDF. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235759PLOS

Single-cell radioluminescence microscopy with two-fold higher sensitivity using dual scintillator configuration.

PLoS One 2020 7;15(7):e0221241. Epub 2020 Jul 7.

Department of Radiation Oncology, Stanford School of Medicine, Stanford, California, United States of America.

Radioluminescence microscopy (RLM) is an imaging technique that allows quantitative analysis of clinical radiolabeled drugs and probes in single cells. However, the modality suffers from slow data acquisition (15-30 minutes), thus critically affecting experiments with short-lived radioactive drugs. To overcome this issue, we suggest an approach that significantly accelerates data collection. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221241PLOS

Prevalence of depressive symptoms among nurses in China: A systematic review and meta-analysis.

PLoS One 2020 7;15(7):e0235448. Epub 2020 Jul 7.

Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, People's Republic of China.

Background: Depression is one of the most common mental disorders, profoundly impacting an individual's performance and quality of life. Due to their unique working conditions, nursing is counted among the occupational groups at high risk for developing depression. Because of the shortage of nursing resources in China, Chinese nurses suffer from heavy daily workloads more than those in many other countries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235448PLOS

MEK activation drives glycolysis and supports suppressive myeloid cells in TNBC.

JCI Insight 2020 Jul 7. Epub 2020 Jul 7.

Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America.

Triple-negative breast cancers (TNBCs) are highly heterogeneous and aggressive, with high mortality rates. Although TNBC is typically more responsive to chemotherapy than other breast cancer subtypes, many patients develop chemo-resistance. The molecular processes contributing to chemo-resistance, and the roles of tumor cell-stromal crosstalk in establishing chemo-resistance are complex and largely unclear. Read More

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http://dx.doi.org/10.1172/jci.insight.134290DOI Listing

The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD.

JCI Insight 2020 Jul 7. Epub 2020 Jul 7.

Department of Nephrology and Hypertension, Mayo Clinic, Rochester, United States of America.

Background: A treatment option for ADPKD has highlighted the need to identify rapidly progressive patients. Kidney size/age and genotype have predictive power for renal outcomes, but their relative and additive value, plus associated trajectories of disease progression, are not well defined.

Methods: The value of genotypic and/or kidney imaging data (Mayo Imaging Class) to predict the time to functional (end stage kidney disease; ESKD, or decline in estimated glomerular filtration rate; eGFR) or structural (increase in height adjusted total kidney volume; htTKV) outcomes were evaluated in a Mayo Clinic PKD1/PKD2 population; and eGFR and htTKV trajectories from 20-65 years of age modeled and independently validated in similarly defined CRISP and HALT PKD patients. Read More

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http://dx.doi.org/10.1172/jci.insight.138724DOI Listing

Megakaryocytes promote osteoclastogenesis in aging.

Aging (Albany NY) 2020 Jul 7;12. Epub 2020 Jul 7.

Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN 46202, USA.

Megakaryocytes (MKs) support bone formation by stimulating osteoblasts (OBs) and inhibiting osteoclasts (OCs). Aging results in higher bone resorption, leading to bone loss. Whereas previous studies showed the effects of aging on MK-mediated bone formation, the effects of aging on MK-mediated OC formation is poorly understood. Read More

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http://dx.doi.org/10.18632/aging.103595DOI Listing

Gambling in adolescence: a narrative review of the last 20 years.

J Addict Dis 2020 Jul 7:1-20. Epub 2020 Jul 7.

Department of Cognitive Sciences, Psychology, Educational and Cultural Studies (COSPECS), University of Messina, Messina, Italy.

Background: Gambling has increasingly become a problem in adolescence over the last 20 years. Previous research has failed to identify exactly the level of involvement of adolescents in gambling, yet a relevant presence of addictive behaviors was noticed.

Objective: This narrative review highlights the implications of adolescent gambling, taking into consideration the main risk and protection factors aimed at limiting gambling activity, as well as the main links with the impulse-control disorder, addiction, and behavioral addiction. Read More

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http://dx.doi.org/10.1080/10550887.2020.1782557DOI Listing

Evaluation of Potential Antigen-specific Host Biomarkers in QuantiFERON Supernatants as Candidates for the Diagnosis of Ocular Tuberculosis.

Ocul Immunol Inflamm 2020 Jul 7:1-9. Epub 2020 Jul 7.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University , Cape Town, South Africa.

Purpose: To evaluate potential host biomarkers detectable in QuantiFERON supernatants as diagnostic candidates for ocular tuberculosis (OTB).

Methods: We investigated 47 host markers in QuantiFERON supernatants from 92 individuals with uveitis using the Luminex platform. We evaluated the potential of individual and combined biomarkers to distinguish between patients with possible, probable, and no OTB. Read More

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http://dx.doi.org/10.1080/09273948.2020.1763404DOI Listing

Apolipoprotein E polymorphism carriers exhibit objective cognitive deficits: a single center trial.

Neurol Res 2020 Jul 7:1-7. Epub 2020 Jul 7.

Department of Neurology, Beijing Luhe Hospital, Capital Medical University , Beijing, China.

Objective: To assess the correlation between objectively measured cognitive function and apolipoprotein E polymorphism within one geographic region.

Methods: 61 patients, aged 55-90 years old, were enrolled in a memory clinic at the Beijing Luhe Hospital affiliated with Capital Medical University from September 2016 to September 2018. At this center, they were evaluated with neuropsychological scales to assess their memory and other aspects of cognitive function. Read More

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http://dx.doi.org/10.1080/01616412.2020.1782130DOI Listing

Drug-coated balloons: Technical and clinical progress.

Vasc Med 2020 Jul 7:1358863X20927791. Epub 2020 Jul 7.

National Heart Centre Singapore, Singapore.

The advancement of drug-coated balloons (DCB) presents an alternative nonstent method in the percutaneous treatment of atherosclerotic lesions. While the current generation of drug-eluting stents (DES) are the device of choice, especially in coronary artery disease (CAD), DCB has potential applications in the treatment of de novo lesions, in-stent restenosis (ISR), bifurcations, and in peripheral artery disease (PAD). In terms of coronary clinical experience, DCB is used most in ISR scenarios and more data are collected to support the use of DCB in de novo lesions compared to best-in-class DES. Read More

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http://dx.doi.org/10.1177/1358863X20927791DOI Listing

The effects of COVID-19 on perioperative morbidity and mortality in patients with hip fractures.

Bone Joint J 2020 Jul 7:1-10. Epub 2020 Jul 7.

University College London Hospitals, The Princess Grace Hospital, and The NIHR Biomedical Research Centre at UCLH, London, UK.

Aims: During the COVID-19 pandemic, many patients continue to require urgent surgery for hip fractures. However, the impact of COVID-19 on perioperative outcomes in these high-risk patients remains unknown. The objectives of this study were to establish the effects of COVID-19 on perioperative morbidity and mortality, and determine any risk factors for increased mortality in patients with COVID-19 undergoing hip fracture surgery. Read More

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http://dx.doi.org/10.1302/0301-620X.102B9.BJJ-2020-1127.R1DOI Listing

The outpatient management of hypertension at two Sierra Leonean health centres: A mixed-method investigation of follow-up compliance and patient-reported barriers to care.

Afr J Prim Health Care Fam Med 2020 Jun 17;12(1):e1-e7. Epub 2020 Jun 17.

Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York.

Background: Sub-Saharan Africa faces an increasing burden of non-communicable diseases. In particular, hypertension and its therapeutic control present a challenge and opportunity for health practitioners and health systems within the region.

Aim: This study sought to assess an initiative conducted by two health clinics to begin treatment of hypertension amongst their patient populations by reviewing medication possession rates and documenting patient-reported barriers to care in the provision of chronic hypertension management. Read More

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http://dx.doi.org/10.4102/phcfm.v12i1.2222DOI Listing

I-Catalyzed Aerobic α,β-Dehydrogenation and Deamination of Tertiary Alkylamines: Highly Selective Synthesis of Polysubstituted Pyrimidines via Hidden Acyclic Enamines.

Org Lett 2020 Jul 7. Epub 2020 Jul 7.

School of Medical Engineering, Xinxiang Key Laboratory of Biomedical Information Research, Henan Engineering Laboratory of Combinatorial Technique for Clinical and Biomedical Big Data, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.

A novel and efficient entrance to the pyrimidine skeleton has been presented via the α,β-dehydrogenation and deamination of tertiary alkylamines. This I-catalyzed dehydrogenative multicomponent procedure utilizes simple aldehydes to trap the hidden enamine intermediates and suspend generation of azadienes from amidines, enabling the difunctionalization of a vicinal C(sp)-H bond. These studies provide valuable possibilities for the introduction of aliphatic substituents and show how to switch to a new reactive modality. Read More

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http://dx.doi.org/10.1021/acs.orglett.0c02001DOI Listing

Magnetothermia-Induced Catalytic Hollow Nanoreactor for Bioorthogonal Organic Synthesis in Living Cells.

Nano Lett 2020 Jul 7. Epub 2020 Jul 7.

Nanoreactors, where rates of the reactions can be controlled remotely by magnetic fields, have tremendous value in biorthogonal chemistry. Here, we introduce silica-confined magnetothermia-induced nanoreactor (MAG-NER) by growing catalytic Pd-nanocrystal selectively on pre-installed iron oxide core inside hollow silica nanoshell, through magnetic-induction. Due to the activation of interfacial catalytic site by stimulated localized magnetothermia and nano-compartmentalization by size selective porous silica, MAG-NER can be conveniently used in complex bio-media, and even can be internalized into living cells for on-demand high performance intramolecular carbocyclization reaction by the remote operation, without compromising the cell viability while maintaining the high catalytic rates. Read More

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http://dx.doi.org/10.1021/acs.nanolett.0c01507DOI Listing

A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy.

Mov Disord 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.

Background: The mutations of KCNMA1 BK-type K channel have been identified in patients with various movement disorders. The underlying pathophysiology and corresponding therapeutics are lacking.

Objectives: To report our clinical and biophysical characterizations of a novel de novo KCNMA1 variant, as well as an effective therapy for the patient's dystonia-atonia spells. Read More

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http://dx.doi.org/10.1002/mds.28138DOI Listing

Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease.

Cochrane Database Syst Rev 2020 Jul 7;7:CD013665. Epub 2020 Jul 7.

NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.

Background: Some people with SARS-CoV-2 infection remain asymptomatic, whilst in others the infection can cause mild to moderate COVID-19 disease and COVID-19 pneumonia, leading some patients to require intensive care support and, in some cases, to death, especially in older adults. Symptoms such as fever or cough, and signs such as oxygen saturation or lung auscultation findings, are the first and most readily available diagnostic information. Such information could be used to either rule out COVID-19 disease, or select patients for further diagnostic testing. Read More

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http://dx.doi.org/10.1002/14651858.CD013665DOI Listing
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