1,480 results match your criteria Biomedical Microdevices[Journal]


Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles.

Biomed Microdevices 2019 Apr 15;21(2):46. Epub 2019 Apr 15.

Department of Transplantation Medicine, Mayo Clinic, Jacksonville, Florida, 32224, USA.

Most clinically approved drugs (primarily small molecules or antibodies) are rapidly cleared from circulation and distribute throughout the body. As a consequence, only a small portion of the dose accumulates at the target site, leading to low efficacy and adverse side effects. Therefore, new delivery strategies are necessary to increase organ and tissue-specific delivery of therapeutic agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0396-7DOI Listing

A quantitative approach for determining the role of geometrical constraints when shaping mesenchymal condensations.

Biomed Microdevices 2019 Apr 8;21(2):44. Epub 2019 Apr 8.

Centre for Craniofacial and Regenerative Biology, Dental Institute, King's College London, London, SE1 9RT, UK.

In embryogenesis, mesenchymal condensation is a critical event during the formation of many organ systems, including cartilage and bone. During organ formation, mesenchymal cells aggregate and undergo compaction while activating developmental programmes. The final three-dimensional form of the organ, as well as cell fates, can be influenced by the size and shape of the forming condensation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0390-0DOI Listing

Polymers for extended-release administration.

Biomed Microdevices 2019 Apr 8;21(2):45. Epub 2019 Apr 8.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

Developing strategies to deliver the required dose of therapeutics into target tissues and cell populations within the body is a principal aim of controlled release and drug delivery. Specifically, there is an interest in developing formulations that can achieve drug concentrations within the therapeutic window, for extended periods of time, with tunable release profiles, and with minimal complication and distress for the patient. To date, drug delivery systems have been developed to serve as depots, triggers, and carriers for therapeutics including small molecules, biologics, and cell-based therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0386-9DOI Listing

In situ three-dimensional printing for reparative and regenerative therapy.

Biomed Microdevices 2019 Apr 6;21(2):42. Epub 2019 Apr 6.

Center for Minimally Invasive Therapeutics (C-MIT), University of California - Los Angeles, California, Los Angeles, USA.

Three-dimensional (3D) bioprinting is an emerging biofabrication technology, driving many innovations and opening new avenues in regenerative therapeutics. The aim of 3D bioprinting is to fabricate grafts in vitro, which can then be implanted in vivo. However, the tissue culture ex vivo carries safety risks and thereby complicated manufacturing equipment and practice are required for tissues to be implanted in the humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0372-2DOI Listing
April 2019
2.877 Impact Factor

Hang on tight: reprogramming the cell with microstructural cues.

Biomed Microdevices 2019 Apr 6;21(2):43. Epub 2019 Apr 6.

Department of Bioengineering and Therapeutic Sciences, University of California, 1700 4th St Rm 204, San Francisco, CA, 94158, USA.

Cells interact intimately with complex microdomains in their extracellular matrix (ECM) and maintain a delicate balance of mechanical forces through mechanosensitive cellular components. Tissue injury results in acute degradation of the ECM and disruption of cell-ECM contacts, manifesting in loss of cytoskeletal tension, leading to pathological cell transformation and the onset of disease. Recently, microscale hydrogel constructs have been developed to provide cells with microdomains to form focal adhesion binding sites, which enable restoration of cytoskeletal tension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0394-9DOI Listing

A tissue chamber chip for assessing nanoparticle mobility in the extravascular space.

Biomed Microdevices 2019 Apr 6;21(2):41. Epub 2019 Apr 6.

Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology, Via Morego 30, 16163, Genoa, Italy.

Although a plethora of nanoparticle configurations have been proposed over the past 10 years, the uniform and deep penetration of systemically injected nanomedicines into the diseased tissue stays as a major biological barrier. Here, a 'Tissue Chamber' chip is designed and fabricated to study the extravascular transport of small molecules and nanoparticles. The chamber comprises a collagen slab, deposited within a PDMS mold, and an 800 μm channel for the injection of the working solution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0398-5DOI Listing
April 2019
1 Read

Investigation of parameters that determine Nano-DC vaccine transport.

Biomed Microdevices 2019 Apr 4;21(2):39. Epub 2019 Apr 4.

Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.

Effective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based therapeutic dendritic cell vaccine (Nano-DC vaccine) where PSM serves both as the vehicle for antigen peptides and an adjuvant. Here, we analyzed parameters that determined dendritic cell uptake of PSM particles and Nano-DC vaccine accumulation in lymphatic tissues in a murine model of HER2-positive breast cancer. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10544-019-0397-6
Publisher Site
http://dx.doi.org/10.1007/s10544-019-0397-6DOI Listing
April 2019
4 Reads
2.877 Impact Factor

Mathematical modeling in cancer nanomedicine: a review.

Biomed Microdevices 2019 Apr 4;21(2):40. Epub 2019 Apr 4.

Mathematics in Medicine Program, The Houston Methodist Research Institute, HMRI R8-122, 6670 Bertner Ave, Houston, TX, 77030, USA.

Cancer continues to be among the leading healthcare problems worldwide, and efforts continue not just to find better drugs, but also better drug delivery methods. The need for delivering cytotoxic agents selectively to cancerous cells, for improved safety and efficacy, has triggered the application of nanotechnology in medicine. This effort has provided drug delivery systems that can potentially revolutionize cancer treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0380-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449316PMC

Project honeybee: Clinical applications for wearable biosensors.

Biomed Microdevices 2019 Apr 1;21(2):37. Epub 2019 Apr 1.

School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, 85287, USA.

Please provide an abstract of 150 to 250 words. The abstract should not contain any undefined abbreviations or unspecified references. The Project Honeybee Observational Clinical Trials were 12-month studies designed to validate the use of commercially available ambulatory medical devices costing $50-$300 for clinical applications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0392-yDOI Listing

Functionalization of endovascular devices with superparamagnetic iron oxide nanoparticles for interventional cardiovascular magnetic resonance imaging.

Biomed Microdevices 2019 Apr 1;21(2):38. Epub 2019 Apr 1.

Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, 6550 Fannin St., Suite 1901, Houston, TX, 77030, USA.

Presently, cardiovascular interventions such as stent deployment and balloon angioplasty are performed under x-ray guidance. However, x-ray fluoroscopy has poor soft tissue contrast and is limited by imaging in a single plane, resulting in imprecise navigation of endovascular instruments. Moreover, x-ray fluoroscopy exposes patients to ionizing radiation and iodinated contrast agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0393-xDOI Listing
April 2019
2.877 Impact Factor

Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract.

Biomed Microdevices 2019 Mar 29;21(2):36. Epub 2019 Mar 29.

Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, SA2 8PP, UK.

Infections of the female reproductive tract are a major cause of morbidity and mortality in humans, requiring significant investment to sustain treatment and representing a major challenge to health. The increasing prevalence of bacterial resistance, and an almost complete absence of new antibiotic therapies for the past five decades, mean there is a desperate need for novel approaches to the treatment of bacterial infections. Within the present study, we demonstrate the effective ex vivo treatment of bacterial infection of the female reproductive tract using a controlled-release, liquid crystal-based platform. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439215PMC

Microfluidic device for the analysis of MDR cancerous cell-derived exosomes' response to nanotherapy.

Biomed Microdevices 2019 Mar 25;21(2):35. Epub 2019 Mar 25.

Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA.

Exosomes are membrane-enclosed extracellular vesicles which have been indicated as important biomarkers of cancerous cell functionality, such as multiple drug resistance (MDR). Nanoparticles based chemotherapy is a promising strategy to overcome MDR by interfering the production and composition of exosomes. Therefore, tumor-derived exosomes post-treatment by nanotherapy are implied to play critical roles of biomarkers on cancer MDR analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0381-1DOI Listing
March 2019
11 Reads

Coupling tumor growth and bio distribution models.

Biomed Microdevices 2019 Mar 25;21(2):33. Epub 2019 Mar 25.

Department of Civil, Environmental and Architectural Engineering, University of Padova, via Marzolo 9, 35131, Padova, Italy.

We couple a tumor growth model embedded in a microenvironment, with a bio distribution model able to simulate a whole organ. The growth model yields the evolution of tumor cell population, of the differential pressure between cell populations, of porosity of ECM, of consumption of nutrients due to tumor growth, of angiogenesis, and related growth factors as function of the locally available nutrient. The bio distribution model on the other hand operates on a frozen geometry but yields a much refined distribution of nutrient and other molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0368-yDOI Listing

Chitosan-based composite bilayer scaffold as an in vitro osteochondral defect regeneration model.

Biomed Microdevices 2019 Mar 25;21(2):34. Epub 2019 Mar 25.

Department of Materials Science & Engineering, University of Washington, Seattle, WA, 98195, USA.

Prolonged osteochondral tissue damage can result in osteoarthritis and decreased quality of life. Multiphasic scaffolds, where different layers model different microenvironments, are a promising treatment approach, yet stable joining between layers during fabrication remains challenging. Here, a bilayer scaffold for osteochondral tissue regeneration was fabricated using thermally-induced phase separation (TIPS). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10544-019-0373-1
Publisher Site
http://dx.doi.org/10.1007/s10544-019-0373-1DOI Listing
March 2019
4 Reads

NCI Alliance for Nanotechnology in Cancer - from academic research to clinical interventions.

Biomed Microdevices 2019 Mar 23;21(2):32. Epub 2019 Mar 23.

Nanodelivery Systems and Devices Branch, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA.

The National Cancer Institute (NCI) of National Institutes of Health has funded and operated the NCI Alliance for Nanotechnology in Cancer - a large multi-disciplinary program which leverages research at the intersection of molecular biology, oncology, physics, chemistry, and engineering to develop innovative cancer interventions. The program has demonstrated that convergence of several scientific disciplines catalyzes innovation and progress in cancer nanotechnology and advances its clinical translation. This paper takes a look at last thirteen years of the Alliance program operations and delineates its outcomes, successes, and outlook for the future. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0360-6DOI Listing

Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing.

Biomed Microdevices 2019 Mar 23;21(2):31. Epub 2019 Mar 23.

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Engineered microscale hydrogels have emerged as promising therapeutic approaches for the treatment of various diseases. These microgels find wide application in the biomedical field because of the ease of injectability, controlled release of therapeutics, flexible means of synthesis, associated tunability, and can be engineered as stimuli-responsive. While bulk hydrogels of several length-scale dimensions have been used for over two decades in drug delivery applications, their use as microscale carriers of drug and cell-based therapies is relatively new. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0358-0DOI Listing

Glioblastoma adhesion in a quick-fit hybrid microdevice.

Biomed Microdevices 2019 Mar 21;21(2):30. Epub 2019 Mar 21.

Micro/Bio/Nanofluidics Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa, 9040495, Japan.

Translational research requires reliable biomedical microdevices (BMMD) to mimic physiological conditions and answer biological questions. In this work, we introduce a reversibly sealed quick-fit hybrid BMMD that is operator-friendly and bubble-free, requires low reagent and cell consumption, enables robust and high throughput performance for biomedical experiments. Specifically, we fabricate a quick-fit poly(methyl methacrylate) and poly(dimethyl siloxane) (PMMA/PDMS) prototype to illustrate its utilities by probing the adhesion of glioblastoma cells (T98G and U251MG) to primary endothelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0382-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428793PMC
March 2019
2 Reads

Influence of the static magnetic field on cell response in a miniaturized optically accessible bioreactor for 3D cell culture.

Biomed Microdevices 2019 03 13;21(1):29. Epub 2019 Mar 13.

Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy.

Hydraulic sealing is a crucial condition for the maintenance of sterility during long term operation of microfluidic bioreactors. We developed a miniaturized optically accessible bioreactor (MOAB) allowing perfused culture of 3D cellularised constructs. In the MOAB, the culture chambers are sealed by magnets that generate a weak static magnetic field (SMF). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0387-8DOI Listing

Microfluidic chip to interface porous microneedles for ISF collection.

Biomed Microdevices 2019 03 7;21(1):28. Epub 2019 Mar 7.

Department of Microsystems Engineering (IMTEK), and Cluster of Excellence BrainLinks-BrainTools, University of Freiburg, Georges-Köhler-Allee 103, D-79110, Freiburg, Germany.

Porous microneedles (MNs) are expected to be applied for diagnostic microfluidic devices such as blood glucose monitoring as they enable a pain-free penetration of human skin and the extraction of interstitial fluids. However, conventional microfluidic systems require additional steps to separate the liquid from a porous structure used for fluid extraction. In this study, we developed a microfluidic system with a hydrodynamically designed interface between a porous MN array and microchannels to enable a direct analysis of liquids extracted by the porous MN array. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0370-4DOI Listing
March 2019
1 Read

CNT bundle-based thin intracochlear electrode array.

Biomed Microdevices 2019 03 7;21(1):27. Epub 2019 Mar 7.

Department of Electrical and Computer Engineering, Seoul National University, Seoul, 08826, South Korea.

Objective: It is known that the insertion of the intracochlear electrode is critical procedure because the damage around cochlear structures can deteriorate hearing restoration. To reduce the trauma during the electrode insertion surgery, we developed a thin and flexible intracochlear electrode array constructed with carbon nanotube (CNT) bundles.

Methods: Each CNT bundle was used for an individual electrode channel after coated with parylene C for insulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0384-yDOI Listing
March 2019
2.877 Impact Factor

The relationship between the Young's modulus and dry etching rate of polydimethylsiloxane (PDMS).

Biomed Microdevices 2019 03 2;21(1):26. Epub 2019 Mar 2.

Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.

Polydimethylsiloxane (PDMS) has been the pivotal materials for microfluidic technologies with tremendous amount of lab-on-a-chip devices made of PDMS microchannels. While molding-based soft-lithography approach has been extremely successful in preparing various PDMS constructs, some complex features have to been achieved through more complicated microfabrication techniques that involve dry etching of PDMS. Several recipes have been reported for reactive ion etching (RIE) of PDMS; however, the etch rates present large variations, even for the same etching recipe, which poses challenges in adopting this process for device fabrication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0379-8DOI Listing
March 2019
7 Reads

A novel and reproducible release mechanism for a drug-delivery system in the gastrointestinal tract.

Biomed Microdevices 2019 02 27;21(1):25. Epub 2019 Feb 27.

Department of Information Technology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.

To establish a reliable, reproducible and accurate release of the drug in the gastrointestinal tract, a novel release mechanism for a controllable drug-delivery system has been investigated. The release mechanism, consisting of a one-way valve for drug release, a drug chamber, two axially magnetized cylindrical permanent magnets and a multi-layer solenoid coil, is hosted in the capsule-shaped shell with diameter 11 mm and length 30 mm. To actuate the coil piston, the two static magnetic fields produced by the two magnets are aligned along the same axis, having the same magnitude, but opposite directions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0383-zDOI Listing
February 2019
1 Read

Immuno-gold silver staining assays on capillary-driven microfluidics for the detection of malaria antigens.

Biomed Microdevices 2019 02 27;21(1):24. Epub 2019 Feb 27.

IBM Research - Zurich, Säumerstrasse 4, CH-8803, Rüschlikon, Switzerland.

Accurate and affordable rapid diagnostic tests (RDTs) are indispensable but often lacking for many infectious diseases. Specifically, there is a lack of highly sensitive malaria RDTs that can detect low antigen concentration at the onset of infection. Here, we present a strategy to improve the sensitivity of malaria RDTs by using capillary-driven microfluidic chips and combining sandwich immunoassays with electroless silver staining. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0376-yDOI Listing
February 2019

Low-voltage electrical cell lysis using a microfluidic device.

Biomed Microdevices 2019 02 21;21(1):22. Epub 2019 Feb 21.

Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China.

Cell lysis, where cellular material is released, is the basis for the separation and purification of cell contents, biochemical analysis, and other related experiments. It is also a key step in molecular, real-time, and cancer diagnoses as well as in the drug screening of pathogens. The current methods of lysing cells have several limitations, such as damage to the activity of cellular components, the need for a large number of cell samples, time-consuming processes, and the danger of high voltage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0369-xDOI Listing
February 2019

Numerical evaluation and experimental validation of cross-flow microfiltration device design.

Biomed Microdevices 2019 02 21;21(1):21. Epub 2019 Feb 21.

Department of Plastics Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA, 01854, USA.

This research presents a comprehensive analysis of the design and validation of a cross-flow microfiltration device for separation of microspheres based on size. Simulation results showed that pillar size, pillar shape, incorporation of back-flow preventers, and rounding of pillar layouts affected flow patterns in a cross-flow microfiltration device. Simulation results suggest that larger pillar sizes reduce filtration capacity by decreasing the density of microfiltration gaps in the device. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0378-9DOI Listing
February 2019

Enhancement of gemcitabine cytotoxicity in pancreatic adenocarcinoma through controlled release of nitric oxide.

Biomed Microdevices 2019 02 21;21(1):23. Epub 2019 Feb 21.

Department of Surgery, Division of Traumatology, Critical Care, and Emergency Surgery, University of Pennsylvania, 51N 39th St. MOB Suite 120, Philadelphia, PA, 19104, USA.

Gemcitabine (GEM) is the first-line treatment for pancreatic adenocarcinoma (PAC) yet chemoresistance is common. Nitric oxide (NO) is the predominant species responsible for the cytotoxic action of macrophages against cancer cells yet localized delivery is difficult given the short half-life. We sought to study the effect of locally delivered NO on GEM mediated PAC cytotoxicity and the potential role of SMAD4 in this effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0375-zDOI Listing
February 2019

A microfluidic device for noninvasive cell electrical stimulation and extracellular field potential analysis.

Biomed Microdevices 2019 02 21;21(1):20. Epub 2019 Feb 21.

Department of Mechanical Engineering, University of Akron, Akron, OH, 44325, USA.

We developed a device that can quickly apply versatile electrical stimulation (ES) signals to cells suspended in microfluidic channels and measure extracellular field potential simultaneously. The device could trap cells onto the surface of measurement electrodes for ES and push them to the downstream channel after ES by increasing pressure for continuous measurement. Cardiomyocytes, major functional cells in heart, together with human fibroblast cells and human umbilical vein endothelial cells, were tested with the device. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0364-2DOI Listing
February 2019

Microfabricaton of microfluidic check valves using comb-shaped moving plug for suppression of backflow in microchannel.

Biomed Microdevices 2019 02 21;21(1):19. Epub 2019 Feb 21.

Department of Mechanical Engineering, Hanyang University, Seoul, 04763, South Korea.

This study reports on an efficient microscale one-way valve system that combines the physical properties of photopolymerized microstructures and viscoelastic microchannels to rectify flows with low Reynolds numbers. The comb-shaped moving plug in the microchannel prevented backflow in the closed state to ensure that the microchannel remained completely blocked in the closed state, but allowed forward flow in the open state. This microfluidic check valve was microfabricated using the combination of the soft lithography and the releasing methods with the use of a double photoresist layer to create microchannels and free-moving comb-shaped microstructures, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0365-1DOI Listing
February 2019

Targeted delivery of 20(S)-ginsenoside Rg3-based polypeptide nanoparticles to treat colon cancer.

Biomed Microdevices 2019 02 20;21(1):18. Epub 2019 Feb 20.

The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.

Colorectal cancer (CRC) is a major malignancy characterized by a high metastasis rate. Systematic chemotherapy is important for patients with advanced CRC. However, many limitations (e. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10544-019-0374-0
Publisher Site
http://dx.doi.org/10.1007/s10544-019-0374-0DOI Listing
February 2019
5 Reads

Biodegradable batteries with immobilized electrolyte for transient MEMS.

Biomed Microdevices 2019 02 12;21(1):17. Epub 2019 Feb 12.

School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Biodegradable batteries play an important role in fully degradable biomedical or environmental systems. The development of biodegradable batteries faces many challenges including power content, device compactness, performance stability, shelf and functional lifetime. In particular, a key driver in the lifetime and overall size of microfabricated biodegradable batteries is the liquid electrolyte volume. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0377-xDOI Listing
February 2019

Stable biphasic interfaces for open microfluidic platforms.

Biomed Microdevices 2019 02 12;21(1):16. Epub 2019 Feb 12.

Department of Chemistry, University of Washington, Seattle, WA, 98195, USA.

We present an open microfluidic platform that enables stable flow of an organic solvent over an aqueous solution. The device features apertures connecting a lower aqueous channel to an upper solvent compartment that is open to air, enabling easy removal of the solvent for analysis. We have previously shown that related open biphasic systems enable steroid hormone extraction from human cells in microscale culture and secondary metabolite extraction from microbial culture; here we build on our prior work by determining conditions under which the system can be used with extraction solvents of ranging polarities, a critical feature for applying this extraction platform to diverse classes of metabolites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0367-zDOI Listing
February 2019

An electromagnetic anglerfish-shaped millirobot with wireless power generation.

Biomed Microdevices 2019 02 11;21(1):15. Epub 2019 Feb 11.

State Key Laboratory of Robotics, Shenyang Institute of Automation, Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, 110016, China.

Female anglerfishes have a lantern-shape luminous organ sprouting from the middle of their heads to lure their prey in the dark deep sea. Inspired by the anglerfish, we designed an electromagnetic anglerfish-shaped millirobot that can receive energy and transform it into light to attract algae cells to specific locations. The small wireless powered robot can receive about 658 mW of power from external energy supply coils, and light LEDs (light-emitting diodes). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0361-5DOI Listing
February 2019
5 Reads

Monitoring drug pharmacokinetics and immunologic biomarkers in dermal interstitial fluid using a microneedle patch.

Biomed Microdevices 2019 02 6;21(1):14. Epub 2019 Feb 6.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA, 30332, USA.

Minimally invasive point-of-care diagnostic devices are of great interest for rapid detection of biomarkers in diverse settings. Although blood is the most common source of biomarkers, interstitial fluid (ISF) is an alternate body fluid that does not clot or contain red blood cells that often complicate analysis. However, ISF is difficult to collect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0363-3DOI Listing
February 2019
1 Read

Co-current crossflow microfiltration in a microchannel.

Biomed Microdevices 2019 02 6;21(1):12. Epub 2019 Feb 6.

Department of Biomedical Engineering, Columbia University, 500 West 120th street #811, New York, NY, 10027, USA.

Steady state crossflow microfiltration (CMF) is an important and often necessary means of particle separation and concentration for both industrial and biomedical processes. The factors controlling the performance of CMF have been extensively reviewed. A major factor is transmembrane pressure (TMP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0362-4DOI Listing
February 2019
2 Reads

WEDM-LS processing sophisticated and durable Zr-based metallic glass mold insert for micro structure injection of polymers.

Biomed Microdevices 2019 02 6;21(1):13. Epub 2019 Feb 6.

College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, 518060, China.

Micro components processed by injection molding still have a defect of bad precision and short life. A Zr- based metallic glass was reported for injection mold insert which can solve the problem well. The microstructure of metallic glass mold insert can be fabricated by wire electrical discharge machining-low speed (WEDM-LS), WEDM-LS has higher machining accuracy than WEDM-high speed, and X-ray diffraction curves show that the processed sample still retained better amorphous characteristic, afterward, time-temperature-transformation diagram shows metallic glass has a long service life in production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0366-0DOI Listing
February 2019

Fiberoptic microindentation technique for early osteoarthritis diagnosis: an in vitro study on human cartilage.

Biomed Microdevices 2019 01 18;21(1):11. Epub 2019 Jan 18.

Photonics Laboratory, Department of Applied Sciences and Mechatronics, Munich University of Applied Sciences, Lothstr. 34, 80335, Munich, Germany.

In this study, the capability of a fiber optic microindenter sensor to discriminate between healthy and slightly degenerated human articular cartilage samples is demonstrated. The purely optical indenter sensor is characterized by extremely reduced dimensions (0.125 mm in diameter and 27 mm in length) in comparison to existing indenter probes offering advantages for endoscopic deployment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-019-0359-zDOI Listing
January 2019
2 Reads

Biaxial sensing suture breakage warning system for robotic surgery.

Biomed Microdevices 2019 01 10;21(1):10. Epub 2019 Jan 10.

Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, 90095, USA.

The number of procedures performed with robotic surgery may exceed one million globally in 2018. The continual lack of haptic feedback, however, forces surgeons to rely on visual cues in order to avoid breaking sutures due to excessive applied force. To mitigate this problem, the authors developed and validated a novel grasper-integrated system with biaxial shear sensing and haptic feedback to warn the operator prior to anticipated suture breakage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0357-6DOI Listing
January 2019
3 Reads

Microneedle-Based Delivery of Amphotericin B for Treatment of Cutaneous Leishmaniasis.

Biomed Microdevices 2019 01 7;21(1). Epub 2019 Jan 7.

Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Box 7115, Raleigh, NC, 27695-7115, USA.

Current therapeutic options against cutaneous leishmaniasis are plagued by several weaknesses. The effective topical delivery of an antileishmanial drug would be useful in treating some forms of cutaneous leishmaniasis. Toward this end, a microneedle based delivery approach for the antileishmanial drug amphotericin B was investigated in murine models of both New World (Leishmania mexicana) and Old World (Leishmania major) infection. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10544-018-0355-8
Publisher Site
http://dx.doi.org/10.1007/s10544-018-0355-8DOI Listing
January 2019
3 Reads

LampPort: a handheld digital microfluidic device for loop-mediated isothermal amplification (LAMP).

Biomed Microdevices 2019 01 7;21(1). Epub 2019 Jan 7.

State Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, Macao SAR, China.

A major goal in the development of point-of-care (POC) devices is to build them as portable to provide a rapid and effective determination for disease pathogens. In nucleic acid testing, an optical detection system used to monitor the product of nucleic acid amplification has always been a bulky accessory. In this work, we developed a handheld, automatic and detection system-free thermal digital microfluidic (DMF) device for DNA detection by loop-mediated isothermal amplification (LAMP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0354-9DOI Listing
January 2019
2 Reads

Rapid and continuous on-chip loading of trehalose into erythrocytes.

Biomed Microdevices 2019 01 3;21(1). Epub 2019 Jan 3.

Center for Biomedical Engineering, University of Science and Technology of China, Hefei, 230027, Anhui, China.

Freeze-drying is a promising approach for the long-term storage of erythrocytes at room temperature. Studies have shown that trehalose loaded into erythrocytes plays an important role in protecting erythrocytes against freeze-drying damage. Due to the impermeability of the erythrocyte membrane to trehalose, many methods have been developed to load trehalose into erythrocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0352-yDOI Listing
January 2019
1 Read

An analytic model of microfluidic system triggered by thermal expansion.

Biomed Microdevices 2019 01 3;21(1). Epub 2019 Jan 3.

State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics & Astronautics, Nanjing, 210016, China.

Microfluidics shows a great importance in fluid control in biomedicine area. Recently, a programmable soft microfluidic system for applications of pharmacology and optogenetics is reported in Cell. Based on the theory of thermal expansion, we established an analytic model to characterize the injection process of the microfluidic systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0351-zDOI Listing
January 2019
1 Read

Stretchable bio-potential electrode with self-similar serpentine structure for continuous, long-term, stable ECG recordings.

Biomed Microdevices 2019 01 3;21(1). Epub 2019 Jan 3.

School of Electrical and Automation Engineering, East China Jiaotong University, Nanchang, 330013, China.

Current stretchable surface electrodes have attracted more and more attentions owing to their potential applications in the fields of biological signal monitoring, wearable human-machine interface (HMI) and Internet of Things (IoT). The paper presents that stretchable bio-potential electrode is designed with the second order self-similar serpentine structure to continuous, long-term, stable ECG signal recordings which is conformal contact with the soft skin surface. FEM and experiments have validated >30% deformability of the surface electrode with second order self-similar structure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0353-xDOI Listing
January 2019
2 Reads

Study of diffusive- and convective-transport mediated microtumor growth in a controlled microchamber.

Biomed Microdevices 2019 01 3;21(1). Epub 2019 Jan 3.

Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, No. 1, Sec.4, Roosevelt Rd., Taipei, 10617, Taiwan, Republic of China.

In this paper, we report on using mass transport to control nutrition supply of colorectal cancer cells for developing a microtumor in a confined microchamber. To mimic the spatial heterogeneity of a tumor, two microfluidic configurations based on resistive circuits are designed. One has a convection-dominated microchamber to simulate the tumor region proximal to leaky blood vessels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0356-7DOI Listing
January 2019
1 Read

Effect of dosing regimen and microneedle pretreatment on in vitro skin retention of topically applied beta-blockers.

Biomed Microdevices 2018 12 6;20(4):100. Epub 2018 Dec 6.

Department of Pharmaceutical Science and Experimental Therapeutics, University of Iowa College of Pharmacy, 115 South Grand Avenue, Iowa City, IA, 52242, USA.

Topical beta-blocker formulations are commonly used to treat infantile hemangiomas (IHs); however, the skin concentrations and drug permeation through the skin have not been quantified. Microneedles (MNs) may increase local skin concentrations, which could further enhance lesion clearance and improve dosing regimens. The objective of this study was to quantify skin concentrations and drug permeation of two beta-blockers, propranolol and timolol, in vitro after application to intact skin and skin pretreated with solid MNs of two lengths. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0348-7DOI Listing
December 2018
3 Reads

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system.

Biomed Microdevices 2018 12 6;20(4):101. Epub 2018 Dec 6.

Department of Micro and Nanosystems, KTH Royal Institute of Technology, SE-100 44, Stockholm, Sweden.

Continuous glucose monitoring (CGM) has the potential to greatly improve diabetes management. The aim of this work is to show a proof-of-concept CGM device which performs minimally invasive and minimally delayed in-situ glucose sensing in the dermal interstitial fluid, combining the advantages of microneedle-based and commercially available CGM systems. The device is based on the integration of an ultra-miniaturized electrochemical sensing probe in the lumen of a single hollow microneedle, separately realized using standard silicon microfabrication methods. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10544-018-0349-6
Publisher Site
http://dx.doi.org/10.1007/s10544-018-0349-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290652PMC
December 2018
19 Reads

Microfluidic Device for Cell Trapping with Carbon Electrodes Using Dielectrophoresis.

Biomed Microdevices 2018 12 10;20(4):102. Epub 2018 Dec 10.

Department of Mechanical Engineering, Manipal University, Jaipur, India.

Dielectrophoresis (DEP) devices have proven to be one of the most promising tools to transport, accumulate and sort various cells and particles. The major challenge in the development of DEP devices is the high cost, low yield using Microelectromechanical systems (MEMS). In this paper, we demonstrate a facile, low-cost, and high-throughput method of constructing continuous-flow DEP devices using screen-printing technology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0350-0DOI Listing
December 2018
1 Read
2.877 Impact Factor

Flattened fiber-optic ATR sensor enhanced by silver nanoparticles for glucose measurement.

Biomed Microdevices 2018 11 23;20(4):104. Epub 2018 Nov 23.

State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin, China.

This paper proposes a novel fiber attenuated total reflection (ATR) sensor with silver nanoparticles (AgNPs) on the flattened structure based on mid-infrared spectroscopy for detecting low concentration of glucose with high precision. The flattened structure was designed to add the effective optical path length to improve the sensitivity. AgNPs were then deposited on the surface of the flattened area of the fiber via chemical silver mirror reaction for further improving the sensitivity by enhancing the infrared absorption. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0346-9DOI Listing
November 2018
1 Read

Preliminary study on alginate/NIPAM hydrogel-based soft microrobot for controlled drug delivery using electromagnetic actuation and near-infrared stimulus.

Biomed Microdevices 2018 11 16;20(4):103. Epub 2018 Nov 16.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.

Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradability are also being developed. Among them, microrobots that swell and deswell in response to temperature changes caused by external near infrared (NIR) stimuli, focused ultrasound, and an alternating magnetic field, have been receiving a great amount of interest as drug carriers for therapeutic cell delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0344-yDOI Listing
November 2018
3 Reads

Multimodal imaging of the tumor microenvironment and biological responses to immune therapy.

Biomed Microdevices 2018 12 3;20(4):105. Epub 2018 Dec 3.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, 77030, USA.

Beyond heterogeneous cancer cells, the tumor microenvironment includes stromal and immune cells, blood vessels, extracellular matrix and biologically active molecules. Abnormal signaling, uncontrolled proliferation and high interstitial pressure all contribute to a chaotic, non-hierarchical vascular organization. Using an immune competent 4T1 breast adenocarcinoma murine model, this study fully characterizes the architecture and immunocyte milieu of the tumor microenvironment. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10544-018-0347-8
Publisher Site
http://dx.doi.org/10.1007/s10544-018-0347-8DOI Listing
December 2018
20 Reads
2.877 Impact Factor

Combined immunomagnetic capture coupled with ultrasensitive plasmonic detection of circulating tumor cells in blood.

Biomed Microdevices 2018 11 12;20(4):99. Epub 2018 Nov 12.

Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH, 03755, USA.

We demonstrate enhanced on-chip circulating tumor cell (CTC) detection through the incorporation of plasmonic-enhanced near-infrared (NIR) fluorescence screening. Specifically, the performance of plasmonic gold coated chips was evaluated on our previously reported immunomagnetic CTC capture system and compared to the performance of a regular chip. Three main performance metrics were evaluated: capture efficiency, capture reproducibility, and clinical efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10544-018-0333-1DOI Listing
November 2018
2 Reads