A novel photodynamic therapy-based drug delivery system layered on a stent for treating cholangiocarcinoma.
- Po-Chin Liang,
- Kai-Wen Huang,
- Chien-Chih Tung,
- Ming-Chu Chang,
- Fuh-Yu Chang,
- Jau-Min Wong,
- Yu-Ting Chang
Biomed Microdevices 2017 Nov 22;20(1). Epub 2017 Nov 22.
Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
This study aimed to investigate the drug delivery efficacy and bio-effectiveness of a novel photodynamic therapy (PDT)-matrix drug delivery system for cholangiocarcinoma (CCA). Metallic stents were coated with polyurethane (PU) as the first layer. A 2-hydroxyethyl methacrylate (2-HEMA)/ethylene glycol dimethacrylate (EGDMA)/benzoyl peroxide (BPO) layer and a poly(ethylene-co-vinyl acetate) (PEVA)/poly(n-butyl methacrylate) (PBMA)/polyvinylpyrrolidone K30 (K30) layer containing various concentrations of Photofrin were then incorporated onto the stent as the second and third layers. Read More