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    1315 results match your criteria Biomedical Microdevices [Journal]

    1 OF 27

    All-in-one low-intensity pulsed ultrasound stimulation system using piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted cell stimulation.
    Biomed Microdevices 2017 Sep 19;19(4):86. Epub 2017 Sep 19.
    Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology, Daegu, South Korea.
    A novel cell-stimulation system was fabricated using 10 × 29 piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted ultrasonic cell stimulation. Both the diameter of a single pMUT element and the edge-to-edge gap were 120 μm, and the size of a pMUT array was 2.27 × 6. Read More

    Embryonic body culturing in an all-glass microfluidic device with laser-processed 4 μm thick ultra-thin glass sheet filter.
    Biomed Microdevices 2017 Sep 19;19(4):85. Epub 2017 Sep 19.
    Laboratory for Integrated Biodevice, Quantitative Biology Center, RIKEN, Suita, Osaka, 565-0871, Japan.
    In this paper, we report the development and demonstration of a method to fabricate an all-glass microfluidic cell culturing device without circulation flow. On-chip microfluidic cell culturing is an indispensable technique for cellular replacement therapies and experimental cell biology. Polydimethylsiloxane (PDMS) have become a popular material for fabricating microfluidic cell culture devices because it is a transparent, biocompatible, deformable, easy-to-mold, and gas-permeable. Read More

    Analyzing polymeric matrix for fabrication of a biodegradable microneedle array to enhance transdermal delivery.
    Biomed Microdevices 2017 Sep 19;19(4):84. Epub 2017 Sep 19.
    College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
    Traditional drug delivery systems, using invasive, transdermal, and oral routes, are limited by various factors, such as the digestive system environment, skin protection, and sensory nerve stimulation. To improve the drug delivery system, we fabricated a polysaccharide-based, dissolvable microneedle-based array, which combines the advantages of both invasive and transdermal delivery systems, and promises to be an innovative solution for minimally invasive drug delivery. In this study, we designed a reusable aluminum mold that greatly improved the efficiency and convenience of microneedle fabrication. Read More

    A flexible cell concentrator using inertial focusing.
    Biomed Microdevices 2017 Sep 11;19(4):83. Epub 2017 Sep 11.
    Biosensor National Special Laboratory, Key Laboratory of BME of the Ministry of Education, Zhejiang University, Hangzhou, 310027, China.
    Cell concentration adjustment is intensively implemented routinely both in research and clinical laboratories. Centrifuge is the most prevalent technique for tuning biosample concentration. But it suffers from a number of drawbacks, such as requirement of experienced operator, high cost, low resolution, variable reproducibility and induced damage to sample. Read More

    An exploration of the reflow technique for the fabrication of an in vitro microvascular system to study occlusive clots.
    Biomed Microdevices 2017 Sep 8;19(4):82. Epub 2017 Sep 8.
    Department of Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, Canada.
    Embolic ischemia and pulmonary embolism are health emergencies that arise when a particle such as a blood clot occludes a smaller blood vessel in the brain or the lungs, and restricts flow of blood downstream of the vessel. In this work, the reflow technique (Wang et al. Biomed. Read More

    Development of a shear stress-free microfluidic gradient generator capable of quantitatively analyzing single-cell morphology.
    Biomed Microdevices 2017 Sep 7;19(4):81. Epub 2017 Sep 7.
    Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
    Microfluidics, the science of engineering fluid streams at the micrometer scale, offers unique tools for creating and controlling gradients of soluble compounds. Gradient generation can be used to recreate complex physiological microenvironments, but is also useful for screening purposes. For example, in a single experiment, adherent cells can be exposed to a range of concentrations of the compound of interest, enabling high-content analysis of cell behaviour and enhancing throughput. Read More

    Development of a biodegradable flow resisting polymer membrane for a novel glaucoma microstent.
    Biomed Microdevices 2017 Aug 26;19(4):78. Epub 2017 Aug 26.
    Institute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Straße 4, 18119, Rostock, Germany.
    Within this paper we analyzed the technical feasibility of a novel microstent for glaucoma therapy. For lowering of intraocular pressure, the flexible polyurethane (PUR) implant is designed to drain aqueous humour from the anterior chamber of the eye into subconjunctival, or alternatively suprachoroidal, space. The microstent includes a biodegradable, flow resisting polymer membrane serving as temporary flow resistance for the prevention of early postoperative hypotony. Read More

    Development of a novel intra-abdominal pressure transducer for large scale clinical studies.
    Biomed Microdevices 2017 Aug 26;19(4):80. Epub 2017 Aug 26.
    Department of Bioengineering, University of Utah, 36 S. Wasatch Drive Rm. 3100, Salt Lake City, UT, 84112, USA.
    Intra-abdominal pressure may be one of the few modifiable risk factors associated with developing a pelvic floor disorder. With one in eight women having surgery to correct a pelvic floor disorder in their lifetimes, intra-abdominal pressure may be a key to understanding the disease etiology and how to mitigate its occurrence and progression. Many traditional methods of intra-abdominal pressure measurement have limitations in data quality, environment of use, and patient comfort. Read More

    Wireless induction coils embedded in diamond for power transfer in medical implants.
    Biomed Microdevices 2017 Aug 26;19(4):79. Epub 2017 Aug 26.
    Bionics Institute, 384 Albert St, East Melbourne, VIC, 3002, Australia.
    Wireless power and data transfer to medical implants is a research area where improvements in current state-of-the-art technologies are needed owing to the continuing efforts for miniaturization. At present, lithographical patterning of evaporated metals is widely used for miniature coil fabrication. This method produces coils that are limited to low micron or nanometer thicknesses leading to high impedance values and thus limiting their potential quality. Read More

    Polymer-based interconnection cables to integrate with flexible penetrating microelectrode arrays.
    Biomed Microdevices 2017 Aug 25;19(4):76. Epub 2017 Aug 25.
    Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
    There have been various types of interconnection methods for neural interfacing electrodes, such as silicon ribbon cables, wire bonding and polymer-based cables. In this study, interconnection cables were developed for integration with a Flexible Penetrating Microelectrode Array (FPMA) that was previously developed for neural signal recording or stimulation. Polyimide and parylene C were selected as base materials for the interconnection cables as both materials can preserve the flexibility of the FPMA better than other interconnection methods such as silicon ribbon cable or wire bonding. Read More

    MEMS measurements of single cell stiffness decay due to cyclic mechanical loading.
    Biomed Microdevices 2017 Aug 25;19(4):77. Epub 2017 Aug 25.
    Mechanical Engineering Department, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
    The goal of this study was to measure the mechanical stiffness of individual cells and to observe changes due to the application of repeated cell mechanical loads. 28 single baker's yeast cells (Saccharomyces cerevisiae) were fatigue tested and had their stiffness measured during repetitive loading cycles performed by a MEMS squeezer in aqueous media. Electrothermal micro-actuators compressed individual cells against a reference back spring; cell and spring motions were measured using a FFT image analysis technique with ~10 nm resolution. Read More

    PDMS based multielectrode arrays for superior in-vitro retinal stimulation and recording.
    Biomed Microdevices 2017 Aug 25;19(4):75. Epub 2017 Aug 25.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
    Understanding of the neural response to electrical stimulation requires simultaneous recording from the various neurons of retina. Electrodes form the physical interface with the neural or retinal tissue. Successful retinal stimulation and recording demands conformal integration of these electrodes with the soft tissue to ensure establishment of proper electrical connection with the excitable tissue. Read More

    Hands-free smartphone-based diagnostics for simultaneous detection of Zika, Chikungunya, and Dengue at point-of-care.
    Biomed Microdevices 2017 Aug 22;19(4):73. Epub 2017 Aug 22.
    Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
    Infectious diseases remain the world's top contributors to death and disability, and, with recent outbreaks of Zika virus infections there has been an urgency for simple, sensitive and easily translatable point-of-care tests. Here we demonstrate a novel point-of-care platform to diagnose infectious diseases from whole blood samples. A microfluidic platform performs minimal sample processing in a user-friendly diagnostics card followed by real-time reverse-transcription loop-mediated isothermal amplification (RT-LAMP) on the same card with pre-dried primers specific to viral targets. Read More

    Fabrication and characterization of low-cost, bead-free, durable and hydrophobic electrospun membrane for 3D cell culture.
    Biomed Microdevices 2017 Aug 22;19(4):74. Epub 2017 Aug 22.
    Queensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane, QLD, 4111, Australia.
    This paper reports the fabrication of electrospun polydimethylsiloxane (PDMS) membranes/scaffolds that are suitable for three-dimensional (3D) cell culture. Through modification the ratio between PDMS and polymethylmethacrylate (PMMA) as carrier polymer, we report the possibility of increasing PDMS weight ratio of up to 6 for electrospinning. Increasing the PDMS content increases the fiber diameter, the pore size, and the hydrophobicity. Read More

    Biocontractile microfluidic channels for peristaltic pumping.
    Biomed Microdevices 2017 Aug 9;19(4):72. Epub 2017 Aug 9.
    Laboratory of Biophysics of Excitable Systems, Moscow Institute of Physics and Technology, 9 Institutskiy per., Dolgoprudny, Moscow Region, Russian Federation, 141701.
    Bio-actuated micro-pumps do not need any external power source and pose no risk of electrical or heat shock for the biological materials in lab-on-chip systems. Several different designs of bio-actuated micro-pumps based on the use of the contractile force of cultured cardiomyocites have been proposed earlier. Here we present a novel type of a bio-actuated micro-pump representing a microfluidic channel with a contractile wall. Read More

    A multiscale fluidic device for the study of dendrite-mediated cell to cell communication.
    Biomed Microdevices 2017 Aug 8;19(3):71. Epub 2017 Aug 8.
    The City College of New York, 160 Convent Ave., New York, NY, 10031, USA.
    Many cell types communicate by means of dendritic extensions via a multi-tiered set of geometric and chemical cues. Until recently, mimicking the compartmentalized in vivo cellular environment of dendrite-expressing cells such as osteocytes and motor neurons in a spatially and temporally controllable manner was limited by the challenges of in vitro device fabrication at submicron scales. Utilizing the improved resolution of current fabrication technology, we have designed a multiscale device, the Macro-micro-nano system, or Mμn, composed of two distinct cell-seeding and interrogation compartments separated by a nanochannel array. Read More

    Development of a co-culture device for the study of human tenocytes in response to the combined stimulation of electric field and platelet rich plasma (PRP).
    Biomed Microdevices 2017 Sep;19(3):69
    Department of Orthopedic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
    One of the objectives of rotator cuff repairs is to achieve biological healing and recovery in the tendon-bone zone. Some clinical evaluations reported the feasibility of tendon healing based on the stimulations of electric field and platelet-rich plasma (PRP). However, because of lack of appropriate tool for in vitro primary culture under complicated conditions, the efficacy and standard protocol of these healing approaches are still controversial among clinical experts. Read More

    Rapid prototyping and parametric optimization of plastic acoustofluidic devices for blood-bacteria separation.
    Biomed Microdevices 2017 Sep;19(3):70
    Draper, 555 Technology Square, Cambridge, MA, 02139, USA.
    Acoustic manipulation has emerged as a versatile method for microfluidic separation and concentration of particles and cells. Most recent demonstrations of the technology use piezoelectric actuators to excite resonant modes in silicon or glass microchannels. Here, we focus on acoustic manipulation in disposable, plastic microchannels in order to enable a low-cost processing tool for point-of-care diagnostics. Read More

    Multifractal-based nuclei segmentation in fish images.
    Biomed Microdevices 2017 Sep;19(3):67
    School of Electrical Engineering, University of Belgrade, Belgrade, Serbia.
    The method for nuclei segmentation in fluorescence in-situ hybridization (FISH) images, based on the inverse multifractal analysis (IMFA) is proposed. From the blue channel of the FISH image in RGB format, the matrix of Holder exponents, with one-by-one correspondence with the image pixels, is determined first. The following semi-automatic procedure is proposed: initial nuclei segmentation is performed automatically from the matrix of Holder exponents by applying predefined hard thresholding; then the user evaluates the result and is able to refine the segmentation by changing the threshold, if necessary. Read More

    An array of porous microneedles for transdermal monitoring of intercellular swelling.
    Biomed Microdevices 2017 Sep;19(3):68
    Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai, 980-8579, Japan.
    An array of porous microneedles was developed for minimally-invasive transdermal electrolytic connection through the human skin barrier, the stratum corneum. The length of microneedle was designed to be 100 μm so that it penetrates into the epidermis layer without pain. Each microneedle was supported by a thicker cylindrical post protruding from a planar substrate to realize its effective penetration even into elastic human skin. Read More

    Combination of antibody-coated, physical-based microfluidic chip with wave-shaped arrays for isolating circulating tumor cells.
    Biomed Microdevices 2017 Sep;19(3):66
    School of Mechanical Engineering, Xi' an Technological University, Xi' an Shaanxi, 710021, China.
    Circulating tumor cells (CTCs) are found in the peripheral blood of patients with metastatic cancers, which have critical significance in cancer prognosis and diagnostics. Enumeration is significantly valuable since number of CTCs is strongly correlated to severity of disease. This article is proposed and demonstrated an antibody-coated, size-based microfluidic chip with wave-shaped arrays could efficiently capture CTCs combining two separation methods of both size- and deformability-based and affinity-based segregation. Read More

    Non-electrolytic microelectroporation.
    Biomed Microdevices 2017 Sep;19(3):65
    Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, 94720, USA.
    Micro and nano technologies are of increasing importance in microfluidics devices used for electroporation (electroporation - the permeabilization of the cell membrane with brief high electric field pulses). Electrochemical reactions of electrolysis occur whenever an electric current flows between an electrode and an ionic solution. It can have substantial detrimental effects, both on the cells and solutions during the electroporation. Read More

    Point-of-care coagulation monitoring: first clinical experience using a paper-based lateral flow diagnostic device.
    Biomed Microdevices 2017 Sep;19(3):64
    James L. Winkle College of Pharmacy, University of Cincinnati, 3225 Eden Avenue, Cincinnati, OH, 45267, USA.
    Vitamin K antagonists such as warfarin are the most widely used class of oral anticoagulants. Due to a narrow therapeutic window, patients on warfarin require regular monitoring. Self-testing using point-of-care (POC) diagnostic devices is available, but cost makes this monitoring method beyond reach for many. Read More

    Study of the behavior of Euglena viridis, Euglena gracilis and Lepadella patella cultured in all-glass microaquarium.
    Biomed Microdevices 2017 Sep;19(3):63
    Faculty of Microsystem Electronics and Photonics, Wrocław University of Science and Technology, 11/17 Janiszewskiego St, 50-372, Wrocław, Poland.
    In the paper, the microaquarium fabricated in a form of entirely glass lab-on-a-chip for culturing and microscale study of microorganisms has been presented. A new approach towards cellular studies that brings a significant improvement over commonly utilized - polymer-based solutions has been shown. For the first time, all-borosilicate glass chip was applied for the culturing of the selected microorganisms and enabled notable population growth and behaviorism investigation. Read More

    Long term performance of porous platinum coated neural electrodes.
    Biomed Microdevices 2017 Sep;19(3):62
    Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA.
    Over the last several years, there has been a growing interest in neural implants for the study and diagnostics of neurological disorders as well as for the symptomatic treatment of central nervous system related diseases. One of the major challenges is the trade-off between small electrode sizes for high selectivity between single neurons and large electrode-tissue interface areas for excellent stimulation and recording properties. This paper presents an approach of increasing the real surface area of the electrodes by creating a surface microstructure. Read More

    Impedance feedback control of microfluidic valves for reliable post processing combinatorial droplet injection.
    Biomed Microdevices 2017 Sep;19(3):61
    Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall 118B, Baltimore, MD, 21218, USA.
    Droplet microfluidics has found use in many biological assay applications as a means of high-throughput sample processing. One of the challenges of the technology, however, is the ability to control and merge droplets on-demand as they flow through the microdevices. It is in the interest of developing lab-on-chip devices to be able to combinatorically program additive mixing steps for more complex multistep and multiplex assays. Read More

    Integration of solid-state nanopores into a functional device designed for electrical and optical cross-monitoring.
    Biomed Microdevices 2017 Sep;19(3):60
    LAAS-CNRS, Université de Toulouse, CNRS, INSA, UPS, Toulouse, France.
    We present a new strategy for fabricating a silicon nanopore device allowing straightforward fluidic integration and electrical as well as optical monitoring. The device presents nanopores of diameters 10 nm to 160 nm, and could therefore be used to obtain solvent-free free-standing lipid bilayers from small unilamellar vesicles (SUV) or large unilamellar vesicles (LUV). The silicon chip fabrication process only requires front side processing of a silicon-on-insulator (SOI) substrate. Read More

    Microfluidic device flow field characterization around tumor spheroids with tunable necrosis produced in an optimized off-chip process.
    Biomed Microdevices 2017 Sep;19(3):59
    Okinawa Institute of Science and Technology Graduate School, 1919-1 Tancha, Onna-son, Okinawa, 904-0495, Japan.
    Tumor spheroids are a 3-D tumor model that holds promise for testing cancer therapies in vitro using microfluidic devices. Tailoring the properties of a tumor spheroid is critical for evaluating therapies over a broad range of possible indications. Using human colon cancer cells (HCT-116), we demonstrate controlled tumor spheroid growth rates by varying the number of cells initially seeded into microwell chambers. Read More

    Bubble removal with the use of a vacuum pressure generated by a converging-diverging nozzle.
    Biomed Microdevices 2017 Sep;19(3):58
    Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.
    Bubbles are an intrinsic problem in microfluidic devices and they can appear during the initial filling of the device or during operation. This report presents a generalizable technique to extract bubbles from microfluidic networks using an adjacent microfluidic negative pressure network over the entire microfluidic channel network design. We implement this technique by superimposing a network of parallel microchannels with a vacuum microfluidic channel and characterize the bubble extraction rates as a function of negative pressure applied. Read More

    Carbon nanotubes embedded in embryoid bodies direct cardiac differentiation.
    Biomed Microdevices 2017 Sep;19(3):57
    WPI-Advanced Institute for Materials Research, Tohoku University, Sendai, 980-8577, Japan.
    We embedded carbon nanotubes (CNTs) in mouse embryoid bodies (EBs) for modulating mechanical and electrical cues of the stem cell niche. The CNTs increased the mechanical integrity and electrical conductivity of the EBs. Measured currents for the unmodified EBs (hereafter, EBs) and the EBs-0. Read More

    Role of key genetic mutations on increasing migration of brain cancer cells through confinement.
    Biomed Microdevices 2017 Sep;19(3):56
    Department of Bioengineering, University of Texas at Arlington, 500 UTA Blvd ERB244, Arlington, TX, 76010, USA.
    Uncontrolled invasive cancer cell migration is among the major challenges for the treatment and management of brain cancer. Although the genetic profiles of brain cancer cells have been well characterized, the relationship between the genetic mutations and the cells' mobility has not been clearly understood. In this study, using microfluidic devices that provide a wide range of physical confinements from 20 × 5 μm(2) to 3 × 5 μm(2) in cross sections, we studied the effect of physical confinement on the migratory capacity of cell lines with different types of mutations. Read More

    Cell-laden microgel prepared using a biocompatible aqueous two-phase strategy.
    Biomed Microdevices 2017 Sep;19(3):55
    Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan.
    Microfluidic methods are frequently used to produce cell-laden microgels for various biomedical purposes. Such microfluidic methods generally employ oil-water systems. The poor distribution of crosslinking reagents in the oil phase limits the available gelation strategies. Read More

    Probing of peripheral blood mononuclear cells anchoring on TNF-alpha challenged-vascular endothelia in an in vitro model of the retinal microvascular.
    Biomed Microdevices 2017 Sep;19(3):54
    Institute for Clean energy & Advanced Materials, Faculty of Materials & Energy, Southwest University, Chongqing, 400715, China.
    Retinopathy is a complication of diabetes that affects the eyes; it stems from damage to the microvasculature of the retina and eventually compromises vision. The diagnosis of retinopathy is difficult to make because there are no early symptoms or warning signs. Dysfunction of the retina's microvascular networks is believed to be associated with inflammatory cytokines and tumor necrosis factor alpha (TNF-α). Read More

    Fabrication of highly modulable fibrous 3D extracellular microenvironments.
    Biomed Microdevices 2017 Sep;19(3):53
    State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210093, People's Republic of China.
    Three-dimensional (3D) in vitro scaffolds that mimic the irregular fibrous structures of in vivo extracellular matrix (ECM) are critical for many important biological applications. However, structural properties modulation of fibrous 3D scaffolds remains a challenge. Here, we report the first highly modulable 3D fibrous scaffolds self-assembled by high-aspect-ratio (HAR) microfibers. Read More

    Packaging of implantable accelerometers to monitor epicardial and endocardial wall motion.
    Biomed Microdevices 2017 Sep;19(3):52
    KU Leuven, ESAT-MICAS, Kasteelpark Arenberg 10, 3001, Leuven, Belgium.
    Acceleration signals, collected from the inner and the outer heart wall, offer a mean of assessing cardiac function during surgery. Accelerometric measurements can also provide detailed insights into myocardial motion during exploratory investigations. Two different implantable accelerometers to respectively record endocardial and epicardial vibrations, have been developed by packaging a commercially available capacitive transducer. Read More

    On the injectability of free-standing magnetic nanofilms.
    Biomed Microdevices 2017 Sep;19(3):51
    Center for MicroBioRobotics IIT@SSSA, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025, Pontedera, Italy.
    Free-standing films with sub-micrometric thickness, composed of soft polymers and functional nanostructures are promising candidates for many potential applications in the biomedical field, such as reduced port abdominal surgery. In this work, freely suspended poly(L-lactic acid) nanofilms with controlled morphology embedding superparamagnetic iron oxide nanoparticles were fabricated by spin-coating deposition. The mechanical properties of magnetic nanofilms were investigated by Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) test. Read More

    Hybrid intracerebral probe with integrated bare LED chips for optogenetic studies.
    Biomed Microdevices 2017 Sep;19(3):49
    Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg, Germany.
    This article reports on the development, i.e., the design, fabrication, and validation of an implantable optical neural probes designed for in vivo experiments relying on optogenetics. Read More

    Nano-Calorimetry based point of care biosensor for metabolic disease management.
    Biomed Microdevices 2017 Sep;19(3):50
    Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
    Point of care (POC) diagnostics represents one of the fastest growing health care technology segments. Developments in microfabrication have led to the development of highly-sensitive nanocalorimeters ideal for directly measuring heat generated in POC biosensors. Here we present a novel nano-calorimeter-based biosensor design with differential sensing to eliminate common mode noise and capillary microfluidic channels for sample delivery to the thermoelectric sensor. Read More

    An improved design of optical sensor for long-term measurement of arterial blood flow waveform.
    Biomed Microdevices 2017 Sep;19(3):48
    Institute of Biophysics, Faculty of Medicine, University of Belgrade, Belgrade, 11000, Serbia.
    We present here the improved design and development of optical sensor for non-invasive measurements of arterial blood flow waveform. The sensor is based on a physical principle of reflective photoplethysmography (PPG). As the light source we used serially connected infrared diodes whereas NPN silicon phototransistors were used as light detectors. Read More

    A 3D microfluidic perfusion system made from glass for multiparametric analysis of stimulus-secretioncoupling in pancreatic islets.
    Biomed Microdevices 2017 Sep;19(3):47
    Center of Pharmaceutical Engineering (PVZ), Technische Universität Braunschweig, 38106, Braunschweig, Germany.
    Microfluidic perfusion systems (MPS) are well suited to perform multiparametric measurements with small amounts of tissue to function as an Organ on Chip device (OOC). Such microphysiolgical characterization is particularly valuable in research on the stimulus-secretion-coupling of pancreatic islets. Pancreatic islets are fully functional competent mini-organs, which serve as fuel sensors and transduce metabolic activity into rates of hormone secretion. Read More

    Accelerated life-test methods and results for implantable electronic devices with adhesive encapsulation.
    Biomed Microdevices 2017 Sep;19(3):46
    Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
    We have developed and applied new methods to estimate the functional life of miniature, implantable, wireless electronic devices that rely on non-hermetic, adhesive encapsulants such as epoxy. A comb pattern board with a high density of interdigitated electrodes (IDE) could be used to detect incipient failure from water vapor condensation. Inductive coupling of an RF magnetic field was used to provide DC bias and to detect deterioration of an encapsulated comb pattern. Read More

    Quantification of microRNAs directly from body fluids using a base-stacking isothermal amplification method in a point-of-care device.
    Biomed Microdevices 2017 Sep;19(3):45
    Department of Civil and Environmental Engineering, Michigan State University, East Lansing, MI, 48824, USA.
    MicroRNAs have been proposed to be a class of biomarkers of disease as expression levels are significantly altered in various tissues and body fluids when compared to healthy controls. As such, the detection and quantification of microRNAs is imperative. While many methods have been established for quantification of microRNAs, they typically rely on time consuming handling such as RNA extraction, purification, or ligation. Read More

    Lipid nanoparticles for administration of poorly water soluble neuroactive drugs.
    Biomed Microdevices 2017 Sep;19(3):44
    Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara, 19, I-44121, Ferrara, Italy.
    This study describes the potential of solid lipid nanoparticles and nanostructured lipid carriers as nano-formulations to administer to the central nervous system poorly water soluble drugs. Different neuroactive drugs, i.e. Read More

    A generic label-free microfluidic microobject sorter using a magnetic elastic diverter.
    Biomed Microdevices 2017 Jun;19(2):43
    Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario, M5S 3G8, Canada.
    Cell sorters play important roles in biological and medical applications, such as cellular behavior study and disease diagnosis and therapy. This work presents a label-free microfluidic sorter that has a downstream-pointing magnetic elastic diverter. Different with most existing magnetic sorters, the proposed device does not require the target microobjects to be intrinsically magnetic or coated with magnetic particles, giving users more flexibility in sorting criteria. Read More

    Remote magnetic switch off microgate for nanofluidic drug delivery implants.
    Biomed Microdevices 2017 Jun;19(2):42
    Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Avenue, R8-216, Houston, TX, 77030, USA.
    In numerous pathologies, implantable drug delivery devices provide advantages over conventional oral or parenteral approaches. Based on the site of implantation and release characteristics, implants can afford either systemic delivery or local administration, whereby the drug is delivered at or near the site of intended action. Unfortunately, current implantable drug delivery systems provide limited options for intervention in the case of an adverse reaction to the drug or the need for dosage adjustment. Read More

    Monoolein aqueous dispersions as a delivery system for quercetin.
    Biomed Microdevices 2017 Jun;19(2):41
    Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara, 19, I-44121, Ferrara, Italy.
    This study describes the preparation, characterization and in vitro release of monoolein aqueous dispersions (MAD) encapsulating quercetin (QT). As emulsifier, sodium cholate was employed at two different concentrations, namely 0.15% and 0. Read More

    Fabrication of cyclo olefin polymer microfluidic devices for trapping and culturing of yeast cells.
    Biomed Microdevices 2017 Jun;19(2):40
    Department of Chemical Engineering, Biosystems Engineering Laboratory, Bogazici University, 34342, Istanbul, Turkey.
    A microfluidic platform is designed and fabricated to investigate the role of uncharacterized YOR060C (Sld7) protein in aging in yeast cells for the first time. Saccharomyces cerevisiae yeast cells are trapped in the series of C-shaped regions (0.5 nL) of COP (cyclo olefin polymer), PMMA (poly methylmethacrylate), or PS (polystyrene) microbioreactors. Read More

    Magneto-Hydrodynamic Fractionation (MHF) for continuous and sheathless sorting of high-concentration paramagnetic microparticles.
    Biomed Microdevices 2017 Jun;19(2):39
    Department of Mechanical Engineering, York University, BRG 433B, 4700 Keele St, Toronto, ON, M3J 1P3, Canada.
    Sorting cells, microorganisms and particles from a solution is of paramount importance in many biological applications. An ideal sorting device should work at high throughput, involve simple design, avoid energy consumption, operate without a diluting sheath flow and perform separation with high purity. However, currently available sorting methods such as pinched flow fractionation, hydrodynamic filtration, magnetophoresis and deterministic lateral displacement meet only a few of the above-mentioned characteristics. Read More

    A microfluidic diode for sorting and immobilization of Caenorhabditis elegans.
    Biomed Microdevices 2017 Jun;19(2):38
    Department of Mechanical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
    Caenorhabditis elegans (C. elegans) is a powerful model organism extensively used in studies of human aging and diseases. Despite the numerous advantages of C. Read More

    Microfluidic gut-on-a-chip with three-dimensional villi structure.
    Biomed Microdevices 2017 Jun;19(2):37
    Department of Chemical Engineering, Hongik University, Seoul, South Korea.
    Current in vitro gut models lack physiological relevance, and various approaches have been taken to improve current cell culture models. For example, mimicking the three-dimensional (3D) tissue structure or fluidic environment has been shown to improve the physiological function of gut cells. Here, we incorporated a collagen scaffold that mimics the human intestinal villi into a microfluidic device, thus providing cells with both 3D tissue structure and fluidic shear. Read More

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