1,451 results match your criteria Biomedical Microdevices [Journal]


Biodegradable batteries with immobilized electrolyte for transient MEMS.

Biomed Microdevices 2019 Feb 12;21(1):17. Epub 2019 Feb 12.

School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Biodegradable batteries play an important role in fully degradable biomedical or environmental systems. The development of biodegradable batteries faces many challenges including power content, device compactness, performance stability, shelf and functional lifetime. In particular, a key driver in the lifetime and overall size of microfabricated biodegradable batteries is the liquid electrolyte volume. Read More

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http://dx.doi.org/10.1007/s10544-019-0377-xDOI Listing
February 2019

Stable biphasic interfaces for open microfluidic platforms.

Biomed Microdevices 2019 Feb 12;21(1):16. Epub 2019 Feb 12.

Department of Chemistry, University of Washington, Seattle, WA, 98195, USA.

We present an open microfluidic platform that enables stable flow of an organic solvent over an aqueous solution. The device features apertures connecting a lower aqueous channel to an upper solvent compartment that is open to air, enabling easy removal of the solvent for analysis. We have previously shown that related open biphasic systems enable steroid hormone extraction from human cells in microscale culture and secondary metabolite extraction from microbial culture; here we build on our prior work by determining conditions under which the system can be used with extraction solvents of ranging polarities, a critical feature for applying this extraction platform to diverse classes of metabolites. Read More

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http://dx.doi.org/10.1007/s10544-019-0367-zDOI Listing
February 2019

An electromagnetic anglerfish-shaped millirobot with wireless power generation.

Biomed Microdevices 2019 Feb 11;21(1):15. Epub 2019 Feb 11.

State Key Laboratory of Robotics, Shenyang Institute of Automation, Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, 110016, China.

Female anglerfishes have a lantern-shape luminous organ sprouting from the middle of their heads to lure their prey in the dark deep sea. Inspired by the anglerfish, we designed an electromagnetic anglerfish-shaped millirobot that can receive energy and transform it into light to attract algae cells to specific locations. The small wireless powered robot can receive about 658 mW of power from external energy supply coils, and light LEDs (light-emitting diodes). Read More

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http://dx.doi.org/10.1007/s10544-019-0361-5DOI Listing
February 2019

Monitoring drug pharmacokinetics and immunologic biomarkers in dermal interstitial fluid using a microneedle patch.

Biomed Microdevices 2019 Feb 6;21(1):14. Epub 2019 Feb 6.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA, 30332, USA.

Minimally invasive point-of-care diagnostic devices are of great interest for rapid detection of biomarkers in diverse settings. Although blood is the most common source of biomarkers, interstitial fluid (ISF) is an alternate body fluid that does not clot or contain red blood cells that often complicate analysis. However, ISF is difficult to collect. Read More

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http://dx.doi.org/10.1007/s10544-019-0363-3DOI Listing
February 2019
1 Read

Co-current crossflow microfiltration in a microchannel.

Biomed Microdevices 2019 Feb 6;21(1):12. Epub 2019 Feb 6.

Department of Biomedical Engineering, Columbia University, 500 West 120th street #811, New York, NY, 10027, USA.

Steady state crossflow microfiltration (CMF) is an important and often necessary means of particle separation and concentration for both industrial and biomedical processes. The factors controlling the performance of CMF have been extensively reviewed. A major factor is transmembrane pressure (TMP). Read More

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http://dx.doi.org/10.1007/s10544-019-0362-4DOI Listing
February 2019
1 Read

WEDM-LS processing sophisticated and durable Zr-based metallic glass mold insert for micro structure injection of polymers.

Biomed Microdevices 2019 Feb 6;21(1):13. Epub 2019 Feb 6.

College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, 518060, China.

Micro components processed by injection molding still have a defect of bad precision and short life. A Zr- based metallic glass was reported for injection mold insert which can solve the problem well. The microstructure of metallic glass mold insert can be fabricated by wire electrical discharge machining-low speed (WEDM-LS), WEDM-LS has higher machining accuracy than WEDM-high speed, and X-ray diffraction curves show that the processed sample still retained better amorphous characteristic, afterward, time-temperature-transformation diagram shows metallic glass has a long service life in production. Read More

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http://dx.doi.org/10.1007/s10544-019-0366-0DOI Listing
February 2019

Fiberoptic microindentation technique for early osteoarthritis diagnosis: an in vitro study on human cartilage.

Biomed Microdevices 2019 Jan 18;21(1):11. Epub 2019 Jan 18.

Photonics Laboratory, Department of Applied Sciences and Mechatronics, Munich University of Applied Sciences, Lothstr. 34, 80335, Munich, Germany.

In this study, the capability of a fiber optic microindenter sensor to discriminate between healthy and slightly degenerated human articular cartilage samples is demonstrated. The purely optical indenter sensor is characterized by extremely reduced dimensions (0.125 mm in diameter and 27 mm in length) in comparison to existing indenter probes offering advantages for endoscopic deployment. Read More

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http://dx.doi.org/10.1007/s10544-019-0359-zDOI Listing
January 2019
2 Reads

Biaxial sensing suture breakage warning system for robotic surgery.

Biomed Microdevices 2019 Jan 10;21(1):10. Epub 2019 Jan 10.

Department of Electrical and Computer Engineering, University of California, Los Angeles, CA, 90095, USA.

The number of procedures performed with robotic surgery may exceed one million globally in 2018. The continual lack of haptic feedback, however, forces surgeons to rely on visual cues in order to avoid breaking sutures due to excessive applied force. To mitigate this problem, the authors developed and validated a novel grasper-integrated system with biaxial shear sensing and haptic feedback to warn the operator prior to anticipated suture breakage. Read More

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http://dx.doi.org/10.1007/s10544-018-0357-6DOI Listing
January 2019
1 Read

Microneedle-Based Delivery of Amphotericin B for Treatment of Cutaneous Leishmaniasis.

Biomed Microdevices 2019 Jan 7;21(1). Epub 2019 Jan 7.

Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Box 7115, Raleigh, NC, 27695-7115, USA.

Current therapeutic options against cutaneous leishmaniasis are plagued by several weaknesses. The effective topical delivery of an antileishmanial drug would be useful in treating some forms of cutaneous leishmaniasis. Toward this end, a microneedle based delivery approach for the antileishmanial drug amphotericin B was investigated in murine models of both New World (Leishmania mexicana) and Old World (Leishmania major) infection. Read More

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http://link.springer.com/10.1007/s10544-018-0355-8
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http://dx.doi.org/10.1007/s10544-018-0355-8DOI Listing
January 2019
2 Reads

LampPort: a handheld digital microfluidic device for loop-mediated isothermal amplification (LAMP).

Biomed Microdevices 2019 Jan 7;21(1). Epub 2019 Jan 7.

State Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, Macao SAR, China.

A major goal in the development of point-of-care (POC) devices is to build them as portable to provide a rapid and effective determination for disease pathogens. In nucleic acid testing, an optical detection system used to monitor the product of nucleic acid amplification has always been a bulky accessory. In this work, we developed a handheld, automatic and detection system-free thermal digital microfluidic (DMF) device for DNA detection by loop-mediated isothermal amplification (LAMP). Read More

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http://dx.doi.org/10.1007/s10544-018-0354-9DOI Listing
January 2019
1 Read

Rapid and continuous on-chip loading of trehalose into erythrocytes.

Biomed Microdevices 2019 Jan 3;21(1). Epub 2019 Jan 3.

Center for Biomedical Engineering, University of Science and Technology of China, Hefei, 230027, Anhui, China.

Freeze-drying is a promising approach for the long-term storage of erythrocytes at room temperature. Studies have shown that trehalose loaded into erythrocytes plays an important role in protecting erythrocytes against freeze-drying damage. Due to the impermeability of the erythrocyte membrane to trehalose, many methods have been developed to load trehalose into erythrocytes. Read More

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http://dx.doi.org/10.1007/s10544-018-0352-yDOI Listing
January 2019
1 Read

An analytic model of microfluidic system triggered by thermal expansion.

Biomed Microdevices 2019 Jan 3;21(1). Epub 2019 Jan 3.

State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics & Astronautics, Nanjing, 210016, China.

Microfluidics shows a great importance in fluid control in biomedicine area. Recently, a programmable soft microfluidic system for applications of pharmacology and optogenetics is reported in Cell. Based on the theory of thermal expansion, we established an analytic model to characterize the injection process of the microfluidic systems. Read More

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http://dx.doi.org/10.1007/s10544-018-0351-zDOI Listing
January 2019
1 Read

Stretchable bio-potential electrode with self-similar serpentine structure for continuous, long-term, stable ECG recordings.

Biomed Microdevices 2019 Jan 3;21(1). Epub 2019 Jan 3.

School of Electrical and Automation Engineering, East China Jiaotong University, Nanchang, 330013, China.

Current stretchable surface electrodes have attracted more and more attentions owing to their potential applications in the fields of biological signal monitoring, wearable human-machine interface (HMI) and Internet of Things (IoT). The paper presents that stretchable bio-potential electrode is designed with the second order self-similar serpentine structure to continuous, long-term, stable ECG signal recordings which is conformal contact with the soft skin surface. FEM and experiments have validated >30% deformability of the surface electrode with second order self-similar structure. Read More

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http://dx.doi.org/10.1007/s10544-018-0353-xDOI Listing
January 2019
1 Read

Study of diffusive- and convective-transport mediated microtumor growth in a controlled microchamber.

Biomed Microdevices 2019 Jan 3;21(1). Epub 2019 Jan 3.

Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, No. 1, Sec.4, Roosevelt Rd., Taipei, 10617, Taiwan, Republic of China.

In this paper, we report on using mass transport to control nutrition supply of colorectal cancer cells for developing a microtumor in a confined microchamber. To mimic the spatial heterogeneity of a tumor, two microfluidic configurations based on resistive circuits are designed. One has a convection-dominated microchamber to simulate the tumor region proximal to leaky blood vessels. Read More

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http://dx.doi.org/10.1007/s10544-018-0356-7DOI Listing
January 2019
1 Read

Effect of dosing regimen and microneedle pretreatment on in vitro skin retention of topically applied beta-blockers.

Biomed Microdevices 2018 12 6;20(4):100. Epub 2018 Dec 6.

Department of Pharmaceutical Science and Experimental Therapeutics, University of Iowa College of Pharmacy, 115 South Grand Avenue, Iowa City, IA, 52242, USA.

Topical beta-blocker formulations are commonly used to treat infantile hemangiomas (IHs); however, the skin concentrations and drug permeation through the skin have not been quantified. Microneedles (MNs) may increase local skin concentrations, which could further enhance lesion clearance and improve dosing regimens. The objective of this study was to quantify skin concentrations and drug permeation of two beta-blockers, propranolol and timolol, in vitro after application to intact skin and skin pretreated with solid MNs of two lengths. Read More

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http://dx.doi.org/10.1007/s10544-018-0348-7DOI Listing
December 2018
2 Reads

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system.

Biomed Microdevices 2018 12 6;20(4):101. Epub 2018 Dec 6.

Department of Micro and Nanosystems, KTH Royal Institute of Technology, SE-100 44, Stockholm, Sweden.

Continuous glucose monitoring (CGM) has the potential to greatly improve diabetes management. The aim of this work is to show a proof-of-concept CGM device which performs minimally invasive and minimally delayed in-situ glucose sensing in the dermal interstitial fluid, combining the advantages of microneedle-based and commercially available CGM systems. The device is based on the integration of an ultra-miniaturized electrochemical sensing probe in the lumen of a single hollow microneedle, separately realized using standard silicon microfabrication methods. Read More

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http://link.springer.com/10.1007/s10544-018-0349-6
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http://dx.doi.org/10.1007/s10544-018-0349-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290652PMC
December 2018
14 Reads

Microfluidic Device for Cell Trapping with Carbon Electrodes Using Dielectrophoresis.

Biomed Microdevices 2018 12 10;20(4):102. Epub 2018 Dec 10.

Department of Mechanical Engineering, Manipal University, Jaipur, India.

Dielectrophoresis (DEP) devices have proven to be one of the most promising tools to transport, accumulate and sort various cells and particles. The major challenge in the development of DEP devices is the high cost, low yield using Microelectromechanical systems (MEMS). In this paper, we demonstrate a facile, low-cost, and high-throughput method of constructing continuous-flow DEP devices using screen-printing technology. Read More

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http://dx.doi.org/10.1007/s10544-018-0350-0DOI Listing
December 2018
1 Read
2.877 Impact Factor

Flattened fiber-optic ATR sensor enhanced by silver nanoparticles for glucose measurement.

Biomed Microdevices 2018 11 23;20(4):104. Epub 2018 Nov 23.

State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin, China.

This paper proposes a novel fiber attenuated total reflection (ATR) sensor with silver nanoparticles (AgNPs) on the flattened structure based on mid-infrared spectroscopy for detecting low concentration of glucose with high precision. The flattened structure was designed to add the effective optical path length to improve the sensitivity. AgNPs were then deposited on the surface of the flattened area of the fiber via chemical silver mirror reaction for further improving the sensitivity by enhancing the infrared absorption. Read More

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http://dx.doi.org/10.1007/s10544-018-0346-9DOI Listing
November 2018
1 Read

Preliminary study on alginate/NIPAM hydrogel-based soft microrobot for controlled drug delivery using electromagnetic actuation and near-infrared stimulus.

Biomed Microdevices 2018 11 16;20(4):103. Epub 2018 Nov 16.

Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, Republic of Korea.

Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradability are also being developed. Among them, microrobots that swell and deswell in response to temperature changes caused by external near infrared (NIR) stimuli, focused ultrasound, and an alternating magnetic field, have been receiving a great amount of interest as drug carriers for therapeutic cell delivery. Read More

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http://dx.doi.org/10.1007/s10544-018-0344-yDOI Listing
November 2018
3 Reads

Multimodal imaging of the tumor microenvironment and biological responses to immune therapy.

Biomed Microdevices 2018 12 3;20(4):105. Epub 2018 Dec 3.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, 77030, USA.

Beyond heterogeneous cancer cells, the tumor microenvironment includes stromal and immune cells, blood vessels, extracellular matrix and biologically active molecules. Abnormal signaling, uncontrolled proliferation and high interstitial pressure all contribute to a chaotic, non-hierarchical vascular organization. Using an immune competent 4T1 breast adenocarcinoma murine model, this study fully characterizes the architecture and immunocyte milieu of the tumor microenvironment. Read More

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http://link.springer.com/10.1007/s10544-018-0347-8
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http://dx.doi.org/10.1007/s10544-018-0347-8DOI Listing
December 2018
11 Reads
2.877 Impact Factor

Combined immunomagnetic capture coupled with ultrasensitive plasmonic detection of circulating tumor cells in blood.

Biomed Microdevices 2018 11 12;20(4):99. Epub 2018 Nov 12.

Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH, 03755, USA.

We demonstrate enhanced on-chip circulating tumor cell (CTC) detection through the incorporation of plasmonic-enhanced near-infrared (NIR) fluorescence screening. Specifically, the performance of plasmonic gold coated chips was evaluated on our previously reported immunomagnetic CTC capture system and compared to the performance of a regular chip. Three main performance metrics were evaluated: capture efficiency, capture reproducibility, and clinical efficacy. Read More

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http://dx.doi.org/10.1007/s10544-018-0333-1DOI Listing
November 2018
2 Reads

PDMS-free microfluidic cell culture with integrated gas supply through a porous membrane of anodized aluminum oxide.

Biomed Microdevices 2018 11 10;20(4):98. Epub 2018 Nov 10.

Institute for Microsensors, -actuators and -systems (IMSAS), University of Bremen, Bremen, Germany.

Microfluidic cell cultures are often used in academic research but only rarely in pharmaceutical research because of unsuitable designs, inappropriate choice of materials or incompatibility with standard equipment. In particular, microfluidic cell cultures to control the gaseous microenvironment rely on PDMS despite its disadvantages. We present a novel concept for such a cell culture device that addresses these issues and is made out of hard materials instead of PDMS. Read More

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http://dx.doi.org/10.1007/s10544-018-0343-zDOI Listing
November 2018
1 Read

The effects of irreversible electroporation on the stomach wall after ablating hepatic tissues.

Biomed Microdevices 2018 11 8;20(4):97. Epub 2018 Nov 8.

Department of Anesthesia, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, China.

This study aimed to evaluate the effect of irreversible electroporation (IRE) on the stomach wall after IRE was applied on liver tissues adjacent to the anterior wall of the stomach. IRE ablation was performed in eight Tibet mini-pigs with three lesions per pig. The IRE electrodes were inserted into the liver tissues situated close to the anterior wall of the stomach. Read More

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http://link.springer.com/10.1007/s10544-018-0345-x
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http://dx.doi.org/10.1007/s10544-018-0345-xDOI Listing
November 2018
10 Reads

The microfabrication of mold for polymer microfluidic devices with Zr-based metallic glass.

Biomed Microdevices 2018 11 6;20(4):96. Epub 2018 Nov 6.

School of Mechanics & Engineering Science, Zhengzhou University, Zhengzhou, 450001, China.

Polymer microfluidic devices are used for many purposes such as microarrays and biochips. The key tool for manufacturing these chips in bulk is an appropriate mold. However, the popular material for making molds is nickel or nickel alloys, which have low stiffness and wear out easily. Read More

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http://link.springer.com/10.1007/s10544-018-0342-0
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http://dx.doi.org/10.1007/s10544-018-0342-0DOI Listing
November 2018
7 Reads
2.877 Impact Factor

Microfluidic dielectrophoretic cell manipulation towards stable cell contact assemblies.

Biomed Microdevices 2018 11 6;20(4):95. Epub 2018 Nov 6.

Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.

Cell contact formation, which is the process by which cells are brought into close proximity is an important biotechnological process in cell and molecular biology. Such manipulation is achieved by various means, among which dielectrophoresis (DEP) is widely used due to its simplicity. Here, we show the advantages in the judicious choice of the DEP microelectrode configuration in terms of limiting undesirable effects of dielectric heating on the cells, which could lead to their inactivation or death, as well as the possibility for cell clustering, which is particularly advantageous over the linear cell chain arrangement typically achieved to date with DEP. Read More

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http://dx.doi.org/10.1007/s10544-018-0341-1DOI Listing
November 2018
1 Read
2.877 Impact Factor

A versatile and robust microfluidic device for capillary-sized simple or multiple emulsions production.

Biomed Microdevices 2018 10 30;20(4):94. Epub 2018 Oct 30.

ESPCI Paris, PSL Research University, Inserm U979, CNRS, Institut Langevin, 17 rue Moreau, 75012, Paris, France.

Ultrasound-vaporizable microdroplets can be exploited for targeted drug delivery. However, it requires customized microfluidic techniques able to produce monodisperse, capillary-sized and biocompatible multiple emulsions. Recent development of microfluidic devices led to the optimization of microdroplet production with high yields, low polydispersity and well-defined diameters. Read More

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http://dx.doi.org/10.1007/s10544-018-0340-2DOI Listing
October 2018
1 Read

Dose calculation of radioactive nanoparticles: first considerations for the Design of Theranostic Agents.

Biomed Microdevices 2018 10 29;20(4):93. Epub 2018 Oct 29.

Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA.

The use of radioactive nanoparticles as imaging and therapeutic agents is increasing globally. Indeed, the use of these nanoparticles as perfect theranostic agent is highly anticipated in the pharmaceutical market. Among the radioactive nanoparticles, liposomes, solid lipid nanoparticles and polymeric nanoparticles are the most studied. Read More

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http://link.springer.com/10.1007/s10544-018-0338-9
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http://dx.doi.org/10.1007/s10544-018-0338-9DOI Listing
October 2018
4 Reads

Micromachined optical flow cell for sensitive measurement of droplets in tubing.

Biomed Microdevices 2018 10 29;20(4):92. Epub 2018 Oct 29.

Faculty of Engineering and the Environment, University of Southampton, Southampton, SO17 1BJ, UK.

Here a micromachined flow cell with enhanced optical sensitivity is presented that allows high-throughput analysis of microdroplets. As a droplet flows through multiple concatenated measurement points, the rate of enzymatic reaction in the droplet can be fully characterized without stopping the flow. Since there is no cross-talk between the droplets, the flow cell is capable of continuously measuring biochemical assays in a droplet flow and thus is suitable to be used for continuous point-of-care diagnostics monitoring. Read More

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http://dx.doi.org/10.1007/s10544-018-0337-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208900PMC
October 2018
1 Read

An automated microfluidic chemiluminescence immunoassay platform for quantitative detection of biomarkers.

Biomed Microdevices 2018 10 25;20(4):91. Epub 2018 Oct 25.

National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen, Fujian, China.

A rapid, sensitive and quantitative biomarker detection platform is of great importance to the small clinic or point-of-care (POC) diagnosis. In this work, we realize that an automated diagnostic platform mainly includes two components: (1) an instrument that can complete all steps of the chemiluminescence immunoassay automatically and (2) an integrated microfluidic chip which is disposable and harmless. In the instrument, we adopt vacuum suction cups which are driven by linear motor to realize a simple, effective and convenient control. Read More

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http://link.springer.com/10.1007/s10544-018-0331-3
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http://dx.doi.org/10.1007/s10544-018-0331-3DOI Listing
October 2018
13 Reads

Proliferation arrest, selectivity, and chemosensitivity enhancement of cancer cells treated by a low-intensity alternating electric field.

Biomed Microdevices 2018 10 22;20(4):90. Epub 2018 Oct 22.

Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan.

Elimination of serious side effects is a desired feature of cancer therapy. Alternating electric field treatment is one approach to the non-invasive treatment of cancer. The efficacy and safety of this novel therapy are confirmed for the treatment of glioblastoma multiforme. Read More

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http://link.springer.com/10.1007/s10544-018-0339-8
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http://dx.doi.org/10.1007/s10544-018-0339-8DOI Listing
October 2018
9 Reads

Paper-based graphene oxide biosensor coupled with smartphone for the quantification of glucose in oral fluid.

Biomed Microdevices 2018 10 12;20(4):89. Epub 2018 Oct 12.

School of Mechanical Engineering, Southeast University, Nanjing, 211189, China.

Rapid, disposable, point-of-care (POC) oral fluid testing has gained considerable attention in recent years as saliva contains biomarker and components of the serum proteome that offer important information on both oral and systemic disease. Microfluidic paper-based analytical devices (μPADs) coupled with smartphone reflectance sensing systems have long been considered to be an effective POC tool for the diagnostics of biomarkers in oral fluid. However, the existing portable systems are limited by the poor color distribution in the detection area as well as not being universally applicable. Read More

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http://dx.doi.org/10.1007/s10544-018-0332-2DOI Listing
October 2018
1 Read

Combination therapy comprising irreversible electroporation and hydroxycamptothecin loaded electrospun membranes to treat rabbit VX2 subcutaneous cancer.

Biomed Microdevices 2018 10 11;20(4):88. Epub 2018 Oct 11.

China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, Jilin, 130033, China.

Irreversible electroporation (IRE) is a kind of promising cancer treatment technology. However, local recurrence still occurs because of incomplete ablation. The aim of this study was to investigate the combined therapy of IRE and a hydroxycamptothecin loaded electrospun membrane (EM/HCPT) to treat rabbit VX2 subcutaneous cancer. Read More

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http://dx.doi.org/10.1007/s10544-018-0336-yDOI Listing
October 2018
2 Reads

Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO).

Biomed Microdevices 2018 10 5;20(4):86. Epub 2018 Oct 5.

Department of Bioengineering and Therapeutic Sciences, University of California, 1700 4th St, QB3 Byers Hall Rm 203A, San Francisco, CA, 94158, USA.

While extracorporeal membrane oxygenation (ECMO) is a valuable therapy for patients with lung or heart failure, clinical use of ECMO remains limited due to hemocompatibility concerns with pro-coagulatory hollow fiber membrane geometries. Previously, we demonstrated the feasibility of silicon nanopore (SNM) and micropore (SμM) membranes for transport between two liquid-phase compartments in blood-contacting devices. Herein, we investigate various pore sizes of SNM and SμM membranes - alone or with a polydimethylsiloxane (PDMS) protective coating - for parameters that determine suitability for gas exchange. Read More

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http://link.springer.com/10.1007/s10544-018-0335-z
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http://dx.doi.org/10.1007/s10544-018-0335-zDOI Listing
October 2018
16 Reads

Silicon membrane filter designed by fluid dynamics simulation and near-field stress analysis for selective cell enrichment.

Biomed Microdevices 2018 10 5;20(4):87. Epub 2018 Oct 5.

Medical Device Management and Research, Samsung Advanced Institute of Health Sciences and Technology, Sungkyunkwan University, Seoul, 06351, South Korea.

Selective cell enrichment technologies can play an important role in both diagnostic and therapeutic areas. However, currently used cell sorting techniques have difficulties in rapidly isolating only the desired target cells from a large volume of body fluids. In this work, we developed a filtering system that can quickly separate and highly concentrate cells from a large volume of solution, depending on their size, using a silicon membrane filter. Read More

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http://link.springer.com/10.1007/s10544-018-0334-0
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http://dx.doi.org/10.1007/s10544-018-0334-0DOI Listing
October 2018
6 Reads

Direct application of mechanical stimulation to cell adhesion sites using a novel magnetic-driven micropillar substrate.

Biomed Microdevices 2018 09 26;20(4):85. Epub 2018 Sep 26.

Biomechanics Laboratory, Department of Mechanical Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan.

Cells change the traction forces generated at their adhesion sites, and these forces play essential roles in regulating various cellular functions. Here, we developed a novel magnetic-driven micropillar array PDMS substrate that can be used for the mechanical stimulation to cellular adhesion sites and for the measurement of associated cellular traction forces. The diameter, length, and center-to-center spacing of the micropillars were 3, 9, and 9 μm, respectively. Read More

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http://dx.doi.org/10.1007/s10544-018-0328-yDOI Listing
September 2018
4 Reads

Correction to: Microtissue size and cell-cell communication modulate cell migration in arrayed 3D collagen gels.

Biomed Microdevices 2018 09 18;20(4):84. Epub 2018 Sep 18.

Department of Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames, IA, 50011-2230, USA.

The original version of this article unfortunately contained a mistake. One line indicating statistical significance was improperly placed in Fig. 5. Read More

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http://dx.doi.org/10.1007/s10544-018-0330-4DOI Listing
September 2018
1 Read

A simple pyramid-shaped microchamber towards highly efficient isolation of circulating tumor cells from breast cancer patients.

Biomed Microdevices 2018 09 17;20(4):83. Epub 2018 Sep 17.

College of Electronic and Electrical Engineering, Wuhan Textile University, Wuhan, Hubei, 430200, People's Republic of China.

Isolation and detection of circulating tumor cells (CTCs) has showed a great clinical impact for tumor diagnosis and treatment monitoring. Despite significant progresses of the existing technologies, feasible and cost-effective CTC isolation techniques are more desirable. In this study, a novel method was developed for highly efficient isolation of CTCs from breast cancer patients based on biophysical properties using a pyramid-shaped microchamber. Read More

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http://link.springer.com/10.1007/s10544-018-0326-0
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http://dx.doi.org/10.1007/s10544-018-0326-0DOI Listing
September 2018
10 Reads

Bionic 3D spheroids biosensor chips for high-throughput and dynamic drug screening.

Biomed Microdevices 2018 09 15;20(4):82. Epub 2018 Sep 15.

Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China.

To perform the drug screening, planar cultured cell models are commonly applied to test efficacy and toxicity of drugs. However, planar cultured cells are different from the human 3D organs or tissues in vivo. To simulate the human 3D organs or tissues, 3D spheroids are developed by culturing a small aggregate of cells which reside around the extracellular matrix and interact with other cells in liquid media. Read More

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http://dx.doi.org/10.1007/s10544-018-0329-xDOI Listing
September 2018
3 Reads

Elucidating the mechanism governing cell rotation under DEP using the volumetric polarization and integration method.

Biomed Microdevices 2018 09 8;20(3):81. Epub 2018 Sep 8.

F. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, 522A Robotics and Manufacturing Building, 143 Graham Avenue, Lexington, KY, 40506-0108, USA.

Cell rotation can be achieved by utilizing rotating electric fields through which torques are generated due to phase difference between the dipole moment of cells and the external electric field. While reports of cell rotation under non-rotating electrical fields, such as dielectrophoresis (DEP), are abound, the underlying mechanism is not fully understood. Because of this, contradicting arguments remain regarding if a single cell can rotate under conventional DEP. Read More

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http://dx.doi.org/10.1007/s10544-018-0327-zDOI Listing
September 2018
1 Read

Engineered 3D tumour model for study of glioblastoma aggressiveness and drug evaluation on a detachably assembled microfluidic device.

Biomed Microdevices 2018 09 6;20(3):80. Epub 2018 Sep 6.

Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.

3D models of tumours have emerged as an advanced technique in pharmacology and tumour cell biology, in particular for studying malignant tumours such as glioblastoma multiforme (GBM). Herein, we developed a 3D GBM model on a detachably assembled microfluidic device, which could be used to study GBM aggressiveness and for anti-GBM drug testing. Fundamental characteristics of the GBM microenvironment in terms of 3D tissue organisation, extracellular matrices and blood flow were reproduced in vitro by serial manipulations in the integrated microfluidic device, including GBM spheroid self-assembly, embedding in a collagen matrix, and continuous perfusion culture, respectively. Read More

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http://dx.doi.org/10.1007/s10544-018-0322-4DOI Listing
September 2018
5 Reads
2.880 Impact Factor

A novel combination of quick response code and microfluidic paper-based analytical devices for rapid and quantitative detection.

Biomed Microdevices 2018 09 5;20(3):79. Epub 2018 Sep 5.

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town, 1068 Xueyuan Avenue, Shenzhen, People's Republic of China.

Nowadays, there is great interest in the use of microfluidic paper-based analytical devices (μPADs) for low-cost diagnostics. In most cases, the test equipment is needed. Here we report a new type of device-independent detection method based on timer-paper-based analytical devices, which can be tested by smartphone, and its application for cholesterol detection. Read More

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http://link.springer.com/10.1007/s10544-018-0325-1
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http://dx.doi.org/10.1007/s10544-018-0325-1DOI Listing
September 2018
6 Reads

Impedimetric immunosensor for dengue diagnosis using graphite screen-printed electrodes coated with poly(4-aminophenylacetic acid).

Biomed Microdevices 2018 09 4;20(3):78. Epub 2018 Sep 4.

Laboratório de Eletroquímica e Nanotecnologia Aplicada, Instituto de Ciência e Tecnologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367, Km 583, 5000, Alto da Jacuba, Diamantina-MG, 39100-000, Brazil.

Dengue is an infectious viral disease transmitted by the Aedes aegypti mosquito, the control of which is complex. In addition, the clinical diagnosis is difficult to perform since it resembles other febrile infections; thus, the development of more effective methods to detect dengue virus (DV) has drawn increasing attention. The present study aimed to develop an impedimetric immunosensor for dengue diagnosis using a screen-printed electrode (SPE) functionalized with polymer films derived from 4-aminophenylacetic acid (4-APA). Read More

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http://dx.doi.org/10.1007/s10544-018-0324-2DOI Listing
September 2018
1 Read

Low-stress Microfluidic Density-gradient Centrifugation for Blood Cell Sorting.

Biomed Microdevices 2018 08 28;20(3):77. Epub 2018 Aug 28.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 1918 University Blvd, MCLM 290A, Birmingham, AL, 35294, USA.

Density gradient centrifugation exploits density differences between different blood cells to accomplish separation of peripheral blood mononuclear cells (PBMCs) from polymorphonuclear (PNM) cells, and erythrocytes or red blood cells (RBCs). While density gradient centrifugation offers a label-free alternative avoiding the use of harsh lysis buffers for blood cell isolation, it is a time-consuming and labor-intensive process during which blood cells are subject to high-levels of centrifugal force that can artifactually activate cells. To provide a low-stress alternative to this elegant method, we miniaturized and automated this process using microfluidics to ensure continuous PBMCs isolation from whole blood while avoiding the exposure to high-levels of centrifugal stress in a simple flow-through format. Read More

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http://dx.doi.org/10.1007/s10544-018-0323-3DOI Listing
August 2018
18 Reads

A marker-based contactless catheter-sensing method to detect surgeons' operations for catheterization training systems.

Biomed Microdevices 2018 08 22;20(3):76. Epub 2018 Aug 22.

Department of Neurological, Surgery Faculty of Medicine, Kagawa University, Takamatsu, Kagawa, Japan.

It is challenging to position a catheter or a guidewire within a patient's complicated and delicate vascular structure due to the lack of intuitive visual feedback by only manipulating the proximal part of the surgical instruments. Training is therefore critical before an actual surgery because any mistake due to the surgeon's inexperience can be fatal for the patient. The catheter manipulation skills of experienced surgeons can be useful as input for training novice surgeons. Read More

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http://dx.doi.org/10.1007/s10544-018-0321-5DOI Listing
August 2018
2 Reads

Clogging-free continuous operation with whole blood in a radial pillar device (RAPID).

Biomed Microdevices 2018 08 17;20(3):75. Epub 2018 Aug 17.

Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.

Pillar-based passive microfluidic devices combine the advantages of simple designs, small device footprint, and high selectivity for size-based separation of blood cells. Most of these device designs have been validated with dilute blood samples. Handling whole blood in pillar-based devices is extremely challenging due to clogging. Read More

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http://link.springer.com/10.1007/s10544-018-0319-z
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http://dx.doi.org/10.1007/s10544-018-0319-zDOI Listing
August 2018
13 Reads

Compensatory force measurement and multimodal force feedback for remote-controlled vascular interventional robot.

Biomed Microdevices 2018 08 16;20(3):74. Epub 2018 Aug 16.

Key Laboratory of Convergence Medical Engineering System and Healthcare Technology, Ministry of Industry and Information Technology, Beijing Institute of Technology, Beijing, 100081, China.

Minimally invasive vascular interventional surgery is widely used and remote-controlled vascular interventional surgery robots (RVIRs) are being developed to reduce the occupational risk of the intervening physician in minimally invasive vascular interventional surgeries. Skilled surgeon performs surgeries mainly depending on the detection of collisions. Inaccurate force feedback will be difficult for surgeons to perform surgeries or even results in medical accidents. Read More

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http://dx.doi.org/10.1007/s10544-018-0318-0DOI Listing
August 2018
3 Reads

Chip-on-tip endoscope incorporating a soft robotic pneumatic bending microactuator.

Biomed Microdevices 2018 08 13;20(3):73. Epub 2018 Aug 13.

Department of Mechanical Engineering, KU Leuven and Flanders Make, Celestijnenlaan 300, 3001, Leuven, Belgium.

In the ever advancing field of minimally invasive surgery, flexible instruments with local degrees of freedom are needed to navigate through the intricate topologies of the human body. Although cable or concentric tube driven solutions have proven their merits in this field, they are inadequate for realizing small bending radii and suffer from friction, which is detrimental when automation is envisioned. Soft robotic actuators with locally actuated degrees of freedom are foreseen to fill in this void, where elastic inflatable actuators are very promising due to their S3-principle, being Small, Soft and Safe. Read More

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http://dx.doi.org/10.1007/s10544-018-0317-1DOI Listing
August 2018
2 Reads

Prediction of Microdroplet Breakup Regime in Asymmetric T-Junction Microchannels.

Biomed Microdevices 2018 08 13;20(3):72. Epub 2018 Aug 13.

Texas A&M University, College Station, TX, USA.

Splitting droplets is becoming a major functional component in increasing number of droplet microfluidic applications, and there is an increasing interest in splitting droplets into two daughter droplets with different volumes. However, designing an asymmetric droplet splitter and predicting how a droplet splits in such designs is not trivial. In this study, numerical simulations were conducted to study droplet breakup in asymmetric T-junctions of square cross-sections having different pressure gradient ratios (i. Read More

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http://dx.doi.org/10.1007/s10544-018-0310-8DOI Listing
August 2018
14 Reads

Porous silicon-poly(ε-caprolactone) film composites: evaluation of drug release and degradation behavior.

Biomed Microdevices 2018 08 10;20(3):71. Epub 2018 Aug 10.

Department of Chemistry and Biochemistry, Texas Christian University, Fort Worth, TX, 76129, USA.

This work focuses on an evaluation of novel composites of porous silicon (pSi) with the biocompatible polymer ε-polycaprolactone (PCL) for drug delivery and tissue engineering applications. The degradation behavior of the composites in terms of their morphology along with the effect of pSi on polymer degradation was monitored. PSi particles loaded with the drug camptothecin (CPT) were physically embedded into PCL films formed from electrospun PCL fiber sheets. Read More

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http://dx.doi.org/10.1007/s10544-018-0313-5DOI Listing
August 2018
2 Reads

A paper-based photothermal array using Parafilm to analyze hyperthermia response of tumour cells under local gradient temperature.

Biomed Microdevices 2018 08 9;20(3):68. Epub 2018 Aug 9.

Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715, China.

Temperature is a critical extrinsic physical parameter that determines cell fate. Hyperthermia therapy has become an efficient treatment for tumor ablation. To understand the response of tumor cells under thermal shocks, we present a paper-based photothermal array that can be conveniently coupled with commercial 96-well cell culture plates. Read More

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http://dx.doi.org/10.1007/s10544-018-0311-7DOI Listing
August 2018
5 Reads
2.880 Impact Factor