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    1353 results match your criteria Biomedical Microdevices [Journal]

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    Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface.
    Biomed Microdevices 2018 Feb 19;20(1):21. Epub 2018 Feb 19.
    Electrical and Computer Engineering, Wayne State University, Detroit, MI, USA.
    The cuff electrode provides a stable interface with peripheral nerves, which has been widely used in basic research and clinical practice. Currently, the cuff electrodes are limited by the planar processing of microfabrication. This paper presents a novel cuff electrode using high-aspect ratio carbon nanotubes (CNTs) integrated on a flexible biocompatible parylene. Read More

    A cooperation of catheters and guidewires-based novel remote-controlled vascular interventional robot.
    Biomed Microdevices 2018 Feb 19;20(1):20. Epub 2018 Feb 19.
    Department of Interventional Neuroradiology, Beijing Engineering Technology Research Center for Interventional Neuroradiology, and Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, 10050, China.
    Remote-controlled vascular interventional robots (RVIRs) are being developed to increase the overall accuracy of surgical operations and reduce the occupational risks of intervening physicians, such as radiation exposure and chronic neck/back pain. Several RVIRs have been used to operate catheters or guidewires accurately. However, a lack of cooperation between the catheters and guidewires results in the surgeon being unable to complete complex surgery by propelling the catheter/guidewire to the target position. Read More

    Finite element analysis of hollow out-of-plane HfOmicroneedles for transdermal drug delivery applications.
    Biomed Microdevices 2018 Feb 17;20(1):19. Epub 2018 Feb 17.
    Department of Physics & Nanotechnology, SRM University, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
    Transdermal drug delivery (TDD) based on microneedles is an excellent approach due to its advantages of both traditional transdermal patch and hypodermic syringes. In this paper, the fabrication method of hollow out-of-layer hafnium oxide (HfO) microneedles mainly based on deep reactive ion etching of silicon and atomic layer deposition of HfO is described, and the finite element analysis of the microneedles based on ANSYS software is also presented. The fabrication process is simplified by using a single mask. Read More

    Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis.
    Biomed Microdevices 2018 Feb 14;20(1):18. Epub 2018 Feb 14.
    Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
    Bioreactors are systems that can be used to monitor the response of tissues and cells to candidate drugs. Building on the experience developed in the creation of an osteochondral bioreactor, we have designed a new 3D printed system, which allows optical access to the cells throughout testing for in line monitoring. Because of the use of 3D printing, the fluidics could be developed in the third dimension, thus maintaining the footprint of a single well of a typical 96 well plate. Read More

    Simulative design in macroscale for prospective application to micro-catheters.
    Biomed Microdevices 2018 Feb 9;20(1):17. Epub 2018 Feb 9.
    Department of Mechanical Engineering, Korea Advanced Institute of Science & Technology (KAIST), Science Town, Daejeon, 305-701, South Korea.
    In this paper, a motion-transforming element is applied to the development of a new catheter device. The motion-transforming element structure allows a reduction of linear movement and converts linear movement to rotational movement. The simulative design of micro-catheters is based on a proposed structure called the Operating Mini Station (OMS). Read More

    Correction to: Development of micro mechanical device having two-dimensional array of micro chambers for cell stretching.
    Biomed Microdevices 2018 Feb 9;20(1):16. Epub 2018 Feb 9.
    Graduate School of Sciences and Technology for Innovation, Yamaguchi University, 2-6-1 Tokiwadai, Ube, Yamaguchi, 755-8611, Japan.
    The original article has been corrected. Instances of the character "μ" should be replaced by the term "micro". Read More

    Rapid enumeration of CD4 + T lymphocytes using an integrated microfluidic system based on Chemiluminescence image detection at point-of-care testing.
    Biomed Microdevices 2018 Feb 8;20(1):15. Epub 2018 Feb 8.
    Institute of Micro/Nanotechnology, Old Dominion University, Norfolk, VA, 23529, USA.
    An integrated microfluidic system has been developed for rapid enumeration of CD4 + T lymphocytes at point-of-care (POC) settings. A concise microfluidic chip, which consists of three separate chambers, respectively, for reaction, detection and waste storage, is developed to automate CD4 detection. To simplify CD4 + T lymphocyte enumeration, a single polycarbonate bead immobilized with CD4 antibody is adopted by the microfluidic chip to capture the CD4 antigen in the lysed testing sample. Read More

    Portable low-power thermal cycler with dual thin-film Pt heaters for a polymeric PCR chip.
    Biomed Microdevices 2018 Jan 29;20(1):14. Epub 2018 Jan 29.
    Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
    Polymerase chain reaction (PCR) has been widely used for major definite diagnostic tool, but very limited its place used only indoor such as hospital or diagnosis lab. For the rapid on-site detection of pathogen in an outdoor environment, a low-power cordless polymerase chain reaction (PCR) thermal cycler is crucial module. At this point of view, we proposed a low-power PCR thermal cycler that could be operated in an outdoor anywhere. Read More

    Stromalized microreactor supports murine hematopoietic progenitor enrichment.
    Biomed Microdevices 2018 Jan 20;20(1):13. Epub 2018 Jan 20.
    Department of Surgery, Center for Surgery, Innovation, & Bioengineering, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, MA, 02114, USA.
    There is an emerging need to process, expand, and even genetically engineer hematopoietic stem and progenitor cells (HSPCs) prior to administration for blood reconstitution therapy. A closed-system and automated solution for ex vivo HSC processing can improve adoption and standardize processing techniques. Here, we report a recirculating flow bioreactor where HSCs are stabilized and enriched for short-term processing by indirect fibroblast feeder coculture. Read More

    2DEP cytometry: distributed dielectrophoretic cytometry for live cell dielectric signature measurement on population level.
    Biomed Microdevices 2018 Jan 8;20(1):12. Epub 2018 Jan 8.
    New Technologies for the Information Society European Centre of Excellence, University of West Bohemia, 30614, Pilsen, Czech Republic.
    In this work, a novel force equilibrium method called distributed dielectrophoretic cytometry (2DEP cytometry) was developed. It uses a dielectrophoresis (DEP)-induced vertical translation of live cells in conjunction with particle image velocimetry (PIV) in order to measure probabilistic distribution of DEP forces acting on an entire cell population. The method is integrated in a microfluidic device. Read More

    Finite element modeling to analyze TEER values across silicon nanomembranes.
    Biomed Microdevices 2018 Jan 5;20(1):11. Epub 2018 Jan 5.
    Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY, 14627, USA.
    Silicon nanomembranes are ultrathin, highly permeable, optically transparent and biocompatible substrates for the construction of barrier tissue models. Trans-epithelial/endothelial electrical resistance (TEER) is often used as a non-invasive, sensitive and quantitative technique to assess barrier function. The current study characterizes the electrical behavior of devices featuring silicon nanomembranes to facilitate their application in TEER studies. Read More

    Development of micro mechanical device having two-dimensional array of micro chambers for cell stretching.
    Biomed Microdevices 2018 Jan 5;20(1):10. Epub 2018 Jan 5.
    Graduate School of Sciences and Technology for Innovation, Yamaguchi University, 2-6-1 Tokiwadai, Ube, Yamaguchi, 755-8611, Japan.
    This paper presents a novel cell stretching micro device having two-dimensional array of micro chambers. It enables an in situ time-lapse observation of stretched cell by using an optical microscope with high measurement efficiency. The presented device consists of a cell culture dish and the array of micro chambers made of silicone elastomer and extension structures made of photocurable resin, and is fabricated with MEMS technology. Read More

    Structuring a multi-nodal neural network in vitro within a novel design microfluidic chip.
    Biomed Microdevices 2018 Jan 2;20(1). Epub 2018 Jan 2.
    Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
    Neural network formation is a complex process involving axon outgrowth and guidance. Axon guidance is facilitated by structural and molecular cues from the surrounding microenvironment. Micro-fabrication techniques can be employed to produce microfluidic chips with a highly controlled microenvironment for neural cells enabling longitudinal studies of complex processes associated with network formation. Read More

    Two-photon fabrication of hydrogel microstructures for excitation and immobilization of cells.
    Biomed Microdevices 2017 Dec 29;20(1). Epub 2017 Dec 29.
    Institute of Applied Physics, University of Münster, Münster, 48149, Germany.
    We investigate in vitro fabrication of hydrogel microstructures by two photon laser lithography for single cell immobilization and excitation. Fluorescent yeast cells are embedded in water containing the hydrogel precursor mixtures and cross-linking is used to selectively immobilize a particular cell. Cell viability within the hydrogel precursor is estimated using a life/dead assay and elastic and stiff hydrogel structures are fabricated, immobilizing cells in a microfluidic environment. Read More

    Lab-on-a-chip device made by autohesion-bonded polymers.
    Biomed Microdevices 2017 Dec 18;20(1). Epub 2017 Dec 18.
    Regenerative Medicine Institute (REMEDI) and CÚRAM Centre for Research in Medical, Galway, Ireland.
    Polymers have the obvious advantages of flexibility in design and cost effectiveness to fabricate a lab-on-a-chip (LOC) device. Polyether ether ketone (PEEK) in particular is very attractive choice as it adds biocompatibility in addition to the possibility of hematic sealing in a 3D design. Hereby, we extend our previous successful technology of autohesive hermetic bonding of medical implants into lab-on-a-chip devices. Read More

    A Radial Pillar Device (RAPID) for continuous and high-throughput separation of multi-sized particles.
    Biomed Microdevices 2017 Nov 28;20(1). Epub 2017 Nov 28.
    Indian Institute of Technology Bombay, Mumbai, India.
    Pillar-based microfluidic sorting devices are preferred for isolation of rare cells due to their simple designs and passive operation. Dead-end pillar filters can efficiently capture large rare cells, such as, circulating tumor cells (CTCs), nucleated red blood cells (NRBCs), CD4 cells in HIV patients, etc., but they get clogged easily. Read More

    Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract.
    Biomed Microdevices 2017 Nov 27;20(1). Epub 2017 Nov 27.
    Department of Immunology, Chair of Clinical Immunology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806, Poznan, Poland.
    The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. Read More

    A novel fabrication method of carbon electrodes using 3D printing and chemical modification process.
    Biomed Microdevices 2017 Nov 23;20(1). Epub 2017 Nov 23.
    Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA.
    Three-dimensional (3D) printing is an emerging technique in the field of biomedical engineering and electronics. This paper presents a novel biofabrication method of implantable carbon electrodes with several advantages including fast prototyping, patient-specific and miniaturization without expensive cleanroom. The method combines stereolithography in additive manufacturing and chemical modification processes to fabricate electrically conductive carbon electrodes. Read More

    A novel photodynamic therapy-based drug delivery system layered on a stent for treating cholangiocarcinoma.
    Biomed Microdevices 2017 Nov 22;20(1). Epub 2017 Nov 22.
    Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
    This study aimed to investigate the drug delivery efficacy and bio-effectiveness of a novel photodynamic therapy (PDT)-matrix drug delivery system for cholangiocarcinoma (CCA). Metallic stents were coated with polyurethane (PU) as the first layer. A 2-hydroxyethyl methacrylate (2-HEMA)/ethylene glycol dimethacrylate (EGDMA)/benzoyl peroxide (BPO) layer and a poly(ethylene-co-vinyl acetate) (PEVA)/poly(n-butyl methacrylate) (PBMA)/polyvinylpyrrolidone K30 (K30) layer containing various concentrations of Photofrin were then incorporated onto the stent as the second and third layers. Read More

    Full-wafer in-situ fabrication and packaging of microfluidic flow cytometer with photo-patternable adhesive polymers.
    Biomed Microdevices 2017 Nov 21;20(1). Epub 2017 Nov 21.
    imec, Kapeldreef 75, B-3001, Leuven, Belgium.
    Integration of microelectronics with microfluidics enables sophisticated lab-on-a-chip devices for sensing and actuation. In this paper, we investigate a novel method for in-situ microfluidics fabrication and packaging on wafer level. Two novel photo-patternable adhesive polymers were tested and compared, PA-S500H and DXL-009. Read More

    Molybdenum coated SU-8 microneedle electrodes for transcutaneous electrical nerve stimulation.
    Biomed Microdevices 2017 Nov 21;20(1). Epub 2017 Nov 21.
    Biomedical Engineering, Graduate Program, University of Manitoba, Winnipeg, Manitoba, Canada.
    Electrophysiological devices are connected to the body through electrodes. In some applications, such as nerve stimulation, it is needed to minimally pierce the skin and reach the underneath layers to bypass the impedance of the first layer called stratum corneum. In this study, we have designed and fabricated surface microneedle electrodes for applications such as electrical peripheral nerve stimulation. Read More

    Irreversible electroporation of the uterine cervix in a rabbit model.
    Biomed Microdevices 2017 Nov 14;19(4):103. Epub 2017 Nov 14.
    Guangzhou Fuda Cancer Institute, Fuda Cancer Hospital, Jinan University School of Medicine, No. 2, Tangdexi Road, Tianhe District, Guangzhou, Guangdong Province, 510665, China.
    The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the uterine cervix in a rabbit model. IRE ablation was performed in the cervices of 48 New Zealand rabbits, with one ablation lesion in each animal. Gross pathology, transmission electron microscopy, hematoxylin and eosin (H&E), Masson's trichrome (MT) stain, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed at pre-set time points (0 h, 12 h, 1 d, 2 d, 4 d, 7 d, 14 d, and 28 d post-IRE). Read More

    Engineered bone scaffolds with Dielectrophoresis-based patterning using 3D printing.
    Biomed Microdevices 2017 Nov 13;19(4):102. Epub 2017 Nov 13.
    Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong.
    Patterning of cells into a specific pattern is an important procedure in tissue engineering to facilitate tissue culture and ingrowth. In this paper, a new type of 3D-printed scaffold utilizing dielectrophoresis (DEP) for active cell seeding and patterning was proposed. This scaffold adopted a concentric-ring design that is similar to native bone tissues. Read More

    A microfluidic in-line ELISA for measuring secreted protein under perfusion.
    Biomed Microdevices 2017 Nov 11;19(4):101. Epub 2017 Nov 11.
    Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, 60616, USA.
    Recent progress in the development of microfluidic microphysiological systems such as 'organs-on-chips' and microfabricated cell culture is geared to simulate organ-level physiology. These tissue models leverage microengineering technologies that provide capabilities of presenting cultured cells with input signals in a more physiologically relevant context such as perfused flow. Proteins that are secreted from cells have important information about the health of the cells. Read More

    3D gut-liver chip with a PK model for prediction of first-pass metabolism.
    Biomed Microdevices 2017 Nov 7;19(4):100. Epub 2017 Nov 7.
    Department of Chemical Engineering, Hongik University, Seoul, 121-791, Korea.
    Accurate prediction of first-pass metabolism is essential for improving the time and cost efficiency of drug development process. Here, we have developed a microfluidic gut-liver co-culture chip that aims to reproduce the first-pass metabolism of oral drugs. This chip consists of two separate layers for gut (Caco-2) and liver (HepG2) cell lines, where cells can be co-cultured in both 2D and 3D forms. Read More

    A microfluidic device for quantitative investigation of zebrafish larvae's rheotaxis.
    Biomed Microdevices 2017 Nov 7;19(4):99. Epub 2017 Nov 7.
    Department of Mechanical Engineering, York University, BRG 433B, 4700 Keele St, Toronto, ON, M3J 1P3, Canada.
    Zebrafish is a model organism for various sensory-motor biological studies. Rheotaxis, or the ability of zebrafish to orient and swim against the water stream, is a common behavior that involves multiple sensory-motor processes such as their lateral line and visual systems. Due to the lack of a controllable and easy-to-use assay, zebrafish rheotaxis at larval stages is not well-understood. Read More

    Fabrication of flexible thin polyurethane membrane for tissue engineering applications.
    Biomed Microdevices 2017 Nov 7;19(4):98. Epub 2017 Nov 7.
    Applied Modern Physics Division, Los Alamos National Laboratory, Los Alamos, NM, USA.
    Thin and flexible polymeric membranes play a critical role in tissue engineering applications for example organs-on-a-chip. These flexible membranes can enable mechanical stretch of the engineered tissue to mimic organ-specific biophysical features, such as breathing. In this work, we report the fabrication of thin (<20 μm), stretchable, and biocompatible polyurethane (PU) membranes. Read More

    Measurement of cell traction force with a thin film PDMS cantilever.
    Biomed Microdevices 2017 Nov 4;19(4):97. Epub 2017 Nov 4.
    Division of Electrical and Computer Engineering, Louisiana State University, Baton Rouge, LA, 70809, USA.
    Adherent cells produce cellular traction force (CTF) on a substrate to maintain their physical morphologies, sense external environment, and perform essential cellular functions. Precise characterization of the CTF can expand our knowledge of various cellular processes as well as lead to the development of novel mechanical biomarkers. However, current methods that measure CTF require special substrates and fluorescent microscopy, rendering them less suitable in a clinical setting. Read More

    Correction to: Polymer-based interconnection cables to integrate with flexible penetrating microelectrode arrays.
    Biomed Microdevices 2017 Nov 2;19(4):96. Epub 2017 Nov 2.
    Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
    The original version of this article unfortunately contained a mistake. In Eqs. (1) to (3), the gas constant 'R' should be replaced with Boltzmann constant 'k. Read More

    Dielectrophoretic microbead sorting using modular electrode design and capillary-driven microfluidics.
    Biomed Microdevices 2017 Oct 30;19(4):95. Epub 2017 Oct 30.
    IBM Research-Zurich GmbH, Säumerstrasse 4, 8803, Rüschlikon, Switzerland.
    Multiplexing assays using microbeads in microfluidics offers high flexibility and throughput, but requires the ability to sort particles based on their physical properties. In this paper, we present a continuous method for separating microbeads that is compact, modular and adaptive, employing an optimized electrode layout that alternates sorting and concentration of microbeads using dielectrophoresis and a nested design. By simulating the combined effects of the hydrodynamic drag and dielectrophoresis forces on polystyrene beads, the parameters of the electrode layout and voltage configuration are optimized for maximum separation based on particle size with a small number of slanted planar electrodes. Read More

    Highly efficient isolation and release of circulating tumor cells based on size-dependent filtration and degradable ZnO nanorods substrate in a wedge-shaped microfluidic chip.
    Biomed Microdevices 2017 Oct 25;19(4):93. Epub 2017 Oct 25.
    College of Electronic and Electrical Engineering, Wuhan Textile University, Wuhan, Hubei, 430200, People's Republic of China.
    Circulating tumor cells (CTCs) have been regarded as the major cause of metastasis, holding significant insights for tumor diagnosis and treatment. Although many efforts have been made to develop methods for CTC isolation and release in microfluidic system, it remains significant challenges to realize highly efficient isolation and gentle release of CTCs for further cellular and bio-molecular analyses. In this study, we demonstrate a novel method for CTC isolation and release using a simple wedge-shaped microfluidic chip embedding degradable znic oxide nanorods (ZnNRs) substrate. Read More

    Effect of drug-loaded TiOnanotube arrays on osseointegration in an orthodontic miniscrew: an in-vivo pilot study.
    Biomed Microdevices 2017 Oct 25;19(4):94. Epub 2017 Oct 25.
    Research Institute for Dental Engineering, Gangneung-Wonju National University, Gangneung, 25457, South Korea.
    Osseointegration was evaluated for the surface of miniscrews with TiOnanotube arrays containing drugs in this in-vivo study. The diameter and length of the TiOnanotube arrays were about 70 nm and 5 μm, respectively. Recombinant human bone morphogenetic protein-2 (rhBMP-2) or ibuprofen was loaded in the TiOnanotube arrays with 12 miniscrews. Read More

    A novel method to understand tumor cell invasion: integrating extracellular matrix mimicking layers in microfluidic chips by "selective curing".
    Biomed Microdevices 2017 Oct 17;19(4):92. Epub 2017 Oct 17.
    Microsystems Group, Department of Mechanical Engineering and Institute for Complex Molecular systems (ICMS), Eindhoven University of Technology, Groene Loper 15, 5612AZ, Eindhoven, the Netherlands.
    A major challenge in studying tumor cell invasion into its surrounding tissue is to identify the contribution of individual factors in the tumor microenvironment (TME) to the process. One of the important elements of the TME is the fibrous extracellular matrix (ECM) which is known to influence cancer cell invasion, but exactly how remains unclear. Therefore, there is a need for new models to unravel mechanisms behind the tumor-ECM interaction. Read More

    Characterisation of human induced pluripotent stem cell-derived endothelial cells under shear stress using an easy-to-use microfluidic cell culture system.
    Biomed Microdevices 2017 Oct 9;19(4):91. Epub 2017 Oct 9.
    Institute of Microchemical Technology Co., Ltd., 713A West KSP, 3-2-1 Sakado, Takatsu, Kawasaki, 213-0012, Japan.
    Induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) can contribute to elucidating the pathogenesis of heart and vascular diseases and developing their treatments. Their precise characteristics in fluid flow however remain unclear. Therefore, the aim of the present study is to characterise these features. Read More

    Irreversible electroporation in the eradication of rabbit VX2 cervical tumors.
    Biomed Microdevices 2017 Oct 9;19(4):90. Epub 2017 Oct 9.
    Guangzhou Fuda Cancer Institute, Fuda Cancer Hospital, Jinan University School of Medicine, No. 2, Tangdexi Road, Tianhe District, Guangzhou, Guangdong Province, 510665, China.
    The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the eradication of rabbit VX2 cervical tumors. A VX2 cervical cancer model was first made in 20 New Zealand rabbits. IRE ablation was performed for the cervical cancers of 15 rabbits when the diameter of the tumor was about 1. Read More

    Microfluidic device for novel breast cancer screening by blood test using miRNA beacon probe.
    Biomed Microdevices 2017 Sep 30;19(4):89. Epub 2017 Sep 30.
    PSG Centre for molecular medicine and therapeutics, PSG Institute of Medical Science and Research, Coimbatore, - 641004, India.
    Breast cancer is identified as the highest cause of death in women suffering from cancer. Early diagnosis is the key to increase the survival of breast cancer victims. Molecular diagnosis using biomarkers have advanced much in the recent years. Read More

    Interventional magnetic resonance imaging guided carotid embolectomy using a novel resonant marker catheter: demonstration of preclinical feasibility.
    Biomed Microdevices 2017 Sep 25;19(4):88. Epub 2017 Sep 25.
    Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
    To assess the visualization and efficacy of a wireless resonant circuit (wRC) catheter system for carotid artery occlusion and embolectomy under real-time MRI guidance in vivo, and to compare MR imaging modality with x-ray for analysis of qualitative physiological measures of blood flow at baseline and after embolectomy. The wRC catheter system was constructed using a MR compatible PEEK fiber braided catheter (Penumbra, Inc, Alameda, CA) with a single insulated longitudinal copper loop soldered to a printed circuit board embedded within the catheter wall. In concordance with IACUC protocol (AN103047), in vivo carotid artery navigation and embolectomy were performed in four farm pigs (40-45 kg) under real-time MRI at 1. Read More

    Passive, wireless transduction of electrochemical impedance across thin-film microfabricated coils using reflected impedance.
    Biomed Microdevices 2017 Sep 25;19(4):87. Epub 2017 Sep 25.
    Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB-140, Los Angeles, CA, 90089-1111, USA.
    A new method of wirelessly transducing electrochemical impedance without integrated circuits or discrete electrical components was developed and characterized. The resonant frequency and impedance magnitude at resonance of a planar inductive coil is affected by the load on a secondary coil terminating in sensing electrodes exposed to solution (reflected impedance), allowing the transduction of the high-frequency electrochemical impedance between the two electrodes. Biocompatible, flexible secondary coils with sensing electrodes made from gold and Parylene C were microfabricated and the reflected impedance in response to phosphate-buffered saline solutions of varying concentrations was characterized. Read More

    All-in-one low-intensity pulsed ultrasound stimulation system using piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted cell stimulation.
    Biomed Microdevices 2017 Sep 19;19(4):86. Epub 2017 Sep 19.
    Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science & Technology, Daegu, South Korea.
    A novel cell-stimulation system was fabricated using 10 × 29 piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted ultrasonic cell stimulation. Both the diameter of a single pMUT element and the edge-to-edge gap were 120 μm, and the size of a pMUT array was 2.27 × 6. Read More

    Embryonic body culturing in an all-glass microfluidic device with laser-processed 4 μm thick ultra-thin glass sheet filter.
    Biomed Microdevices 2017 Sep 19;19(4):85. Epub 2017 Sep 19.
    Laboratory for Integrated Biodevice, Quantitative Biology Center, RIKEN, Suita, Osaka, 565-0871, Japan.
    In this paper, we report the development and demonstration of a method to fabricate an all-glass microfluidic cell culturing device without circulation flow. On-chip microfluidic cell culturing is an indispensable technique for cellular replacement therapies and experimental cell biology. Polydimethylsiloxane (PDMS) have become a popular material for fabricating microfluidic cell culture devices because it is a transparent, biocompatible, deformable, easy-to-mold, and gas-permeable. Read More

    Analyzing polymeric matrix for fabrication of a biodegradable microneedle array to enhance transdermal delivery.
    Biomed Microdevices 2017 Sep 19;19(4):84. Epub 2017 Sep 19.
    College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
    Traditional drug delivery systems, using invasive, transdermal, and oral routes, are limited by various factors, such as the digestive system environment, skin protection, and sensory nerve stimulation. To improve the drug delivery system, we fabricated a polysaccharide-based, dissolvable microneedle-based array, which combines the advantages of both invasive and transdermal delivery systems, and promises to be an innovative solution for minimally invasive drug delivery. In this study, we designed a reusable aluminum mold that greatly improved the efficiency and convenience of microneedle fabrication. Read More

    A flexible cell concentrator using inertial focusing.
    Biomed Microdevices 2017 Sep 11;19(4):83. Epub 2017 Sep 11.
    Biosensor National Special Laboratory, Key Laboratory of BME of the Ministry of Education, Zhejiang University, Hangzhou, 310027, China.
    Cell concentration adjustment is intensively implemented routinely both in research and clinical laboratories. Centrifuge is the most prevalent technique for tuning biosample concentration. But it suffers from a number of drawbacks, such as requirement of experienced operator, high cost, low resolution, variable reproducibility and induced damage to sample. Read More

    An exploration of the reflow technique for the fabrication of an in vitro microvascular system to study occlusive clots.
    Biomed Microdevices 2017 Sep 8;19(4):82. Epub 2017 Sep 8.
    Department of Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, Canada.
    Embolic ischemia and pulmonary embolism are health emergencies that arise when a particle such as a blood clot occludes a smaller blood vessel in the brain or the lungs, and restricts flow of blood downstream of the vessel. In this work, the reflow technique (Wang et al. Biomed. Read More

    Development of a shear stress-free microfluidic gradient generator capable of quantitatively analyzing single-cell morphology.
    Biomed Microdevices 2017 Sep 7;19(4):81. Epub 2017 Sep 7.
    Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
    Microfluidics, the science of engineering fluid streams at the micrometer scale, offers unique tools for creating and controlling gradients of soluble compounds. Gradient generation can be used to recreate complex physiological microenvironments, but is also useful for screening purposes. For example, in a single experiment, adherent cells can be exposed to a range of concentrations of the compound of interest, enabling high-content analysis of cell behaviour and enhancing throughput. Read More

    Development of a biodegradable flow resisting polymer membrane for a novel glaucoma microstent.
    Biomed Microdevices 2017 Aug 26;19(4):78. Epub 2017 Aug 26.
    Institute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Straße 4, 18119, Rostock, Germany.
    Within this paper we analyzed the technical feasibility of a novel microstent for glaucoma therapy. For lowering of intraocular pressure, the flexible polyurethane (PUR) implant is designed to drain aqueous humour from the anterior chamber of the eye into subconjunctival, or alternatively suprachoroidal, space. The microstent includes a biodegradable, flow resisting polymer membrane serving as temporary flow resistance for the prevention of early postoperative hypotony. Read More

    Development of a novel intra-abdominal pressure transducer for large scale clinical studies.
    Biomed Microdevices 2017 Aug 26;19(4):80. Epub 2017 Aug 26.
    Department of Bioengineering, University of Utah, 36 S. Wasatch Drive Rm. 3100, Salt Lake City, UT, 84112, USA.
    Intra-abdominal pressure may be one of the few modifiable risk factors associated with developing a pelvic floor disorder. With one in eight women having surgery to correct a pelvic floor disorder in their lifetimes, intra-abdominal pressure may be a key to understanding the disease etiology and how to mitigate its occurrence and progression. Many traditional methods of intra-abdominal pressure measurement have limitations in data quality, environment of use, and patient comfort. Read More

    Wireless induction coils embedded in diamond for power transfer in medical implants.
    Biomed Microdevices 2017 Aug 26;19(4):79. Epub 2017 Aug 26.
    Bionics Institute, 384 Albert St, East Melbourne, VIC, 3002, Australia.
    Wireless power and data transfer to medical implants is a research area where improvements in current state-of-the-art technologies are needed owing to the continuing efforts for miniaturization. At present, lithographical patterning of evaporated metals is widely used for miniature coil fabrication. This method produces coils that are limited to low micron or nanometer thicknesses leading to high impedance values and thus limiting their potential quality. Read More

    Polymer-based interconnection cables to integrate with flexible penetrating microelectrode arrays.
    Biomed Microdevices 2017 Aug 25;19(4):76. Epub 2017 Aug 25.
    Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
    There have been various types of interconnection methods for neural interfacing electrodes, such as silicon ribbon cables, wire bonding and polymer-based cables. In this study, interconnection cables were developed for integration with a Flexible Penetrating Microelectrode Array (FPMA) that was previously developed for neural signal recording or stimulation. Polyimide and parylene C were selected as base materials for the interconnection cables as both materials can preserve the flexibility of the FPMA better than other interconnection methods such as silicon ribbon cable or wire bonding. Read More

    MEMS measurements of single cell stiffness decay due to cyclic mechanical loading.
    Biomed Microdevices 2017 Aug 25;19(4):77. Epub 2017 Aug 25.
    Mechanical Engineering Department, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
    The goal of this study was to measure the mechanical stiffness of individual cells and to observe changes due to the application of repeated cell mechanical loads. 28 single baker's yeast cells (Saccharomyces cerevisiae) were fatigue tested and had their stiffness measured during repetitive loading cycles performed by a MEMS squeezer in aqueous media. Electrothermal micro-actuators compressed individual cells against a reference back spring; cell and spring motions were measured using a FFT image analysis technique with ~10 nm resolution. Read More

    PDMS based multielectrode arrays for superior in-vitro retinal stimulation and recording.
    Biomed Microdevices 2017 Aug 25;19(4):75. Epub 2017 Aug 25.
    School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
    Understanding of the neural response to electrical stimulation requires simultaneous recording from the various neurons of retina. Electrodes form the physical interface with the neural or retinal tissue. Successful retinal stimulation and recording demands conformal integration of these electrodes with the soft tissue to ensure establishment of proper electrical connection with the excitable tissue. Read More

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