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    1380 results match your criteria Biomedical Microdevices [Journal]

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    A patterned polystyrene-based microelectrode array for in vitro neuronal recordings.
    Biomed Microdevices 2018 Jun 16;20(2):48. Epub 2018 Jun 16.
    Department of Materials Science & Engineering, University of Texas at Dallas, Richardson, TX, 75080, USA.
    Substrate-integrated microelectrode arrays (MEAs) are non-invasive platforms for recording supra-threshold signals, i.e. action potentials or spikes, from a variety of cultured electrically active cells, and are useful for pharmacological and toxicological studies. Read More

    In-vitro perforation of the round window membrane via direct 3-D printed microneedles.
    Biomed Microdevices 2018 Jun 8;20(2):47. Epub 2018 Jun 8.
    Department of Mechanical Engineering, Columbia University, 220 Mudd Building 500 West 120th Street, New York, NY, 10027, USA.
    The cochlea, or inner ear, is a space fully enclosed within the temporal bone of the skull, except for two membrane-covered portals connecting it to the middle ear space. One of these portals is the round window, which is covered by the Round Window Membrane (RWM). A longstanding clinical goal is to reliably and precisely deliver therapeutics into the cochlea to treat a plethora of auditory and vestibular disorders. Read More

    A novel electrochemical immunosensor based on Au nanoparticles and horseradish peroxidase signal amplification for ultrasensitive detection of α-fetoprotein.
    Biomed Microdevices 2018 Jun 5;20(2):46. Epub 2018 Jun 5.
    College of Biotechnology, Tianjin University of Science &Technology, Tianjin, 300457, China.
    An electrochemical double-layer Au nanoparticle membrane immunosensor was developed using an electrochemical biosensing signal amplification system with Au nanoparticles, thionine, chitosan, and horseradish peroxidase, which was fabricated using double self-adsorption of Au nanoparticle sol followed by anti-α-fetoprotein Balb/c mouse monoclonal antibody adsorption. The AuNPs sol was characterized by spectrum scanning and transmission electron microscopy. The immunosensor was characterized by atomic force microscopy, cyclic voltammetry, and alternating-current impedance during each stage of adsorption and assembly. Read More

    Robust label-free microRNA detection using one million ISFET array.
    Biomed Microdevices 2018 Jun 2;20(2):45. Epub 2018 Jun 2.
    Department of Bioengineering, University of Illinois at Urbana-Champaign, 1304 W Springfield Ave, Urbana, IL, 61801, USA.
    Detection of nucleic acid molecules is one of the most pervasive assays in biology, medicine, and agriculture applications. Currently, most comely used DNA/RNA detection platforms use fluorescence labeling and require lab-scale setting for performing the assay. There is a need for developing less expensive, label-free, and rapid detection of biomolecules with minimal utilization of resources. Read More

    Self-powered infusion microfluidic pump for ex vivo drug delivery.
    Biomed Microdevices 2018 May 31;20(2):44. Epub 2018 May 31.
    Department of Biosystems, MeBioS-Biosensors Group, KU Leuven, 3001, Leuven, Belgium.
    In this work, we present a new iSIMPLE concept (infusion Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation), which requires no external power for activation nor liquid manipulation, it is easy to use while its fabrication method is extremely simple, inexpensive and suited for mass replication. The pump consists of a working liquid, which is - after finger activation - absorbed in a porous material (e.g. Read More

    A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix.
    Biomed Microdevices 2018 May 28;20(2):43. Epub 2018 May 28.
    Department of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, Ottawa, ON, K1N5N5, Canada.
    Although our understanding of cellular behavior in response to extracellular biological and mechanical stimuli has greatly advanced using conventional 2D cell culture methods, these techniques lack physiological relevance. To a cell, the extracellular environment of a 2D plastic petri dish is artificially flat, extremely rigid, static and void of matrix protein. In contrast, we developed the microtissue vacuum-actuated stretcher (MVAS) to probe cellular behavior within a 3D multicellular environment composed of innate matrix protein, and in response to continuous uniaxial stretch. Read More

    An ultrasonically controlled switching system for power management in implantable devices.
    Biomed Microdevices 2018 May 23;20(2):42. Epub 2018 May 23.
    School of Electrical and Computer Engineering, Purdue University, 1205 W. State St., West Lafayette, IN, 47907, USA.
    In this paper, we present an ultrasonically controlled switching system that can save the battery power for implantable devices by turning the system on and off, on-demand. Ultrasonic control is employed to reduce the device size, increase the penetration depth, and reduce misalignment sensitivity associated with alternative techniques using permanent magnet and RF signal. As a proof-of-concept demonstration, a 665 kHz ultrasonic signal is used to activate a piezoelectric receiver which in turn switches a battery-powered RF system on-and-off. Read More

    A bead-based immunogold-silver staining assay on capillary-driven microfluidics.
    Biomed Microdevices 2018 May 21;20(2):41. Epub 2018 May 21.
    IBM Research - Zurich, Säumerstrasse 4, CH-8803, Rüschlikon, Switzerland.
    Point-of-care (POC) diagnostics are critically needed for the detection of infectious diseases, particularly in remote settings where accurate and appropriate diagnosis can save lives. However, it is difficult to implement immunoassays, and specifically immunoassays relying on signal amplification using silver staining, into POC diagnostic devices. Effective immobilization of antibodies in such devices is another challenge. Read More

    Cardiac support device (ASD) delivers bone marrow stem cells repetitively to epicardium has promising curative effects in advanced heart failure.
    Biomed Microdevices 2018 May 12;20(2):40. Epub 2018 May 12.
    Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, School of Pharmacy, Nanjing, Jiangsu Province, 211198, People's Republic of China.
    Ventricular restraint therapy is a non-transplant surgical option for the management of advanced heart failure (HF). To augment the therapeutic applications, it is hypothesized that ASD shows remarkable capabilities not only in delivering stem cells but also in dilated ventricles. Male SD rats were divided into four groups (n = 6): normal, HF, HF + ASD, and HF + ASD-BMSCs respectively. Read More

    Solid-state nanopore fabrication in LiCl by controlled dielectric breakdown.
    Biomed Microdevices 2018 Apr 21;20(2):38. Epub 2018 Apr 21.
    Department of Biomedical Engineering, Henry M. Rowan College of Engineering, Rowan University, 201 Mullica Hill Road, Glassboro, NJ, 08028, USA.
    Nanopore fabrication via the controlled dielectric breakdown (CDB) method offers an opportunity to create solid-state nanopores directly in salt solution with sub-nanometer precision. Driven by trap assisted current tunneling, the method uses localized defects, or traps, in the dielectric material to isolate a breakdown point and fabricate a single pore in less than 10 minutes. Here we present an approach to controlled dielectric breakdown of SiNx in which the nanopore is fabricated in LiCl buffer instead of the traditional KCl buffer. Read More

    Study on real-time force feedback for a master-slave interventional surgical robotic system.
    Biomed Microdevices 2018 Apr 13;20(2):37. Epub 2018 Apr 13.
    Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantan Xili, Chongwen District, Beijing, China.
    In robot-assisted catheterization, haptic feedback is important, but is currently lacking. In addition, conventional interventional surgical robotic systems typically employ a master-slave architecture with an open-loop force feedback, which results in inaccurate control. We develop herein a novel real-time master-slave (RTMS) interventional surgical robotic system with a closed-loop force feedback that allows a surgeon to sense the true force during remote operation, provide adequate haptic feedback, and improve control accuracy in robot-assisted catheterization. Read More

    The evaluation of E. faecalis colonies dissolution ability of sodium hypochlorite in microenvironment by a novel device.
    Biomed Microdevices 2018 Apr 12;20(2):36. Epub 2018 Apr 12.
    The Department of Endodontics, School of Stomatology, Capital Medical University, Beijing, China.
    Enterococcus faecalis(E. faecalis) is a common microorganism could be isolated from the infected canals, especially in the case of refractory apical periodontitis. Due to its ability to invade the dentinal tubules and highly resistant to antimicrobial strategies, the thorough debridement of E. Read More

    A paperfluidic platform to detect Neisseria gonorrhoeae in clinical samples.
    Biomed Microdevices 2018 Apr 11;20(2):35. Epub 2018 Apr 11.
    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
    Globally, the microbe Neisseria gonorrhoeae (NG) causes 106 million newly documented sexually transmitted infections each year. Once appropriately diagnosed, NG infections can be readily treated with antibiotics, but high-risk patients often do not return to the clinic for treatment if results are not provided at the point of care. A rapid, sensitive molecular diagnostic would help increase NG treatment and reduce the prevalence of this sexually transmitted disease. Read More

    Operation evaluation in-human of a novel remote-controlled vascular interventional robot.
    Biomed Microdevices 2018 Apr 7;20(2):34. Epub 2018 Apr 7.
    Department of Interventional Neuroradiology, Beijing Engineering Technology Research Center for Interventional Neuroradiology, and Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, 10050, China.
    Remote-controlled vascular interventional robots (RVIRs) are being developed to increase the accuracy of surgical operations and reduce the number of occupational risks sustained by intervening physicians, such as radiation exposure and chronic neck/back pain. However, complex control of the RVIRs improves the doctor's operation difficulty and reduces the operation efficiency. Furthermore, incomplete sterilization of the RVIRs will increase the risk of infection, or even cause medical accidents. Read More

    Operating force information on-line acquisition of a novel slave manipulator for vascular interventional surgery.
    Biomed Microdevices 2018 Apr 2;20(2):33. Epub 2018 Apr 2.
    Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
    Vascular interventional surgery has its advantages compared to traditional operation. Master-slave robotic technology can further improve the operation accuracy, efficiency and safety of this complicated and high risk surgery. However, on-line acquisition of operating force information of catheter and guidewire remains to be a significant obstacle on the path to enhancing robotic surgery safety. Read More

    A sample-to-answer droplet magnetofluidic assay platform for quantitative methylation-specific PCR.
    Biomed Microdevices 2018 Mar 28;20(2):31. Epub 2018 Mar 28.
    Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
    Dysregulation of DNA methylation has been identified as an epigenetic biomarker for numerous cancer types. Gene-specific identification techniques relying on methylation-specific PCR (MSP) require a lengthy manual benchtop process that is susceptible to human-error and contamination. This MSP assay requires a series of discrete sample processing steps including genomic DNA extraction, bisulfite conversion and readout via PCR. Read More

    Bioprinted gelatin hydrogel platform promotes smooth muscle cell contractile phenotype maintenance.
    Biomed Microdevices 2018 Mar 28;20(2):32. Epub 2018 Mar 28.
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
    Three dimensional (3D) bioprinting has been proposed as a method for fabricating tissue engineered small diameter vascular prostheses. This technique not only involves constructing the structural features to obtain a desired pattern but the morphology of the pattern may also be used to influence the behavior of seeded cells. Herein, we 3D bioprinted a gelatin hydrogel microchannel construct to promote and preserve the contractile phenotype of vascular smooth muscle cells (vSMCs), which is crucial for vasoresponsiveness. Read More

    A stretchable conductive Polypyrrole Polydimethylsiloxane device fabricated by simple soft lithography and oxygen plasma treatment.
    Biomed Microdevices 2018 Mar 21;20(2):30. Epub 2018 Mar 21.
    Department of Mechanical Engineering, National Central University, Taoyuan, Taiwan.
    This paper reports a simple method used to fabricate a stretchable conductive polypyrrole (PPy) rough pore-shape polydimethylsiloxane (p-PDMS) device. An abrasive paper is first used to imprint rough micro-structures on the SU-8 micromold. The p-PDMS microchannel is then fabricated using a standard soft-lithography process. Read More

    Pre-clinical evaluation of OxyChip for long-term EPR oximetry.
    Biomed Microdevices 2018 Mar 16;20(2):29. Epub 2018 Mar 16.
    Departments of Radiology and Medicine, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH, 03756, USA.
    Tissue oxygenation is a critical parameter in various pathophysiological situations including cardiovascular disease and cancer. Hypoxia can significantly influence the prognosis of solid malignancies and the efficacy of their treatment by radiation or chemotherapy. Electron paramagnetic resonance (EPR) oximetry is a reliable method for repeatedly assessing and monitoring oxygen levels in tissues. Read More

    Closed loop control of microscopic particles incorporating steady streaming and visual feedback.
    Biomed Microdevices 2018 Mar 9;20(2):28. Epub 2018 Mar 9.
    School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.
    Automatic manipulation of microscopic particles is very important in biology, especially in new lab-on-chip systems for automatic testing and DNA manipulation. We suggest a particle manipulation system (PMS) based on vibrating piezoelectric beams creating steady streaming flow in a viscous liquid. The flow is nearly unidirectional and it is used to control the position and velocity of the particles in the workspace of the PMS. Read More

    A novel approach to producing uniform 3-D tumor spheroid constructs using ultrasound treatment.
    Biomed Microdevices 2018 Mar 6;20(2):27. Epub 2018 Mar 6.
    BioMEMS, Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
    Producing three-dimensional (3-D) multicellular tumor spheroids (TSs) is valuable for characterizing anticancer drugs since they provide a more representative model of the 3-D in vivo tumor than conventional two-dimensional (2-D) monolayer culture. The interaction of tumor cells with the extracellular matrix (ECM) in a 3-D culture environment is more similar to a tumor in vivo than in a 2-D environment; cell-cell and cell-ECM interaction can influence cell behaviour, such as in response to drug treatment. In vitro tumor spheroid models have been developed using microfluidic systems to generate 3-D hydrogel beads containing components of alginate and ECM protein, such as collagen, with high uniformity and throughput. Read More

    Development of 3D printed fibrillar collagen scaffold for tissue engineering.
    Biomed Microdevices 2018 Feb 27;20(2):26. Epub 2018 Feb 27.
    Departamento de Química, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
    Collagen is widely used in tissue engineering because it can be extracted in large quantities, and has excellent biocompatibility, good biodegradability, and weak antigenicity. In the present study, we isolated printable collagen from bovine Achilles tendon and examined the purity of the isolated collagen using sodium dodecyl sulfate polyacrylamide gel electrophoresis. The bands obtained corresponded to α, α and β chains with little contamination from other small proteins. Read More

    Proliferation of human aortic endothelial cells on Nitinol thin films with varying hole sizes.
    Biomed Microdevices 2018 Feb 27;20(2):25. Epub 2018 Feb 27.
    Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
    In this paper, we present the effect of micron size holes on proliferation and growth of human aortic endothelial cells (HAECs). Square shaped micron size holes (5, 10, 15, 20 and 25 μm) separated by 10 μm wide struts are fabricated on 5 μm thick sputter deposited Nitinol films. HAECs are seeded onto these micropatterned films and analyzed after 30 days with fluorescence microscopy. Read More

    A practical approach for the optimization of channel integrity in the sealing of shallow microfluidic devices made from cyclic olefin polymer.
    Biomed Microdevices 2018 Feb 24;20(2):24. Epub 2018 Feb 24.
    Center for Manufacturing Innovation, Fraunhofer USA, Brookline, MA, 02446, USA.
    A reduced channel height in microfluidic Lab-on-a-Chip (LOC) devices enables a reduction in the required volume of sample and reagents. LOC devices are most often manufactured by microstructuring a planar substrate and subsequently sealing it with a cover film. However, shallow chip designs, made from polymers, are sensitive to channel deformation during the sealing of the microfluidic device. Read More

    Enhanced particle self-ordering in a double-layer channel.
    Biomed Microdevices 2018 Feb 23;20(2):23. Epub 2018 Feb 23.
    School of Mechanical, Materials, Mechatronic and Biomedical Engineering, University of Wollongong, Wollongong, NSW, 2522, Australia.
    In this work, a novel double-layer microfluidic device for enhancing particle focusing was presented. The double-layer device consists of a channel with expansion-contraction array and periodical slanted grooves. The secondary flows induced by the grooves modulate the flow patterns in the expansion-contraction-array (ECA) channel, further affecting the particle migration. Read More

    Design and performance evaluation of collision protection-based safety operation for a haptic robot-assisted catheter operating system.
    Biomed Microdevices 2018 Feb 23;20(2):22. Epub 2018 Feb 23.
    Faculty of Engineering, Kagawa University, 2217-20 Hayashicho, Takamatsu, Kagawa, Japan.
    The robot-assisted catheter system can increase operating distance thus preventing the exposure radiation of the surgeon to X-ray for endovascular catheterization. However, few designs have considered the collision protection between the catheter tip and the vessel wall. This paper presents a novel catheter operating system based on tissue protection to prevent vessel puncture caused by collision. Read More

    Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface.
    Biomed Microdevices 2018 Feb 19;20(1):21. Epub 2018 Feb 19.
    Electrical and Computer Engineering, Wayne State University, Detroit, MI, USA.
    The cuff electrode provides a stable interface with peripheral nerves, which has been widely used in basic research and clinical practice. Currently, the cuff electrodes are limited by the planar processing of microfabrication. This paper presents a novel cuff electrode using high-aspect ratio carbon nanotubes (CNTs) integrated on a flexible biocompatible parylene. Read More

    A cooperation of catheters and guidewires-based novel remote-controlled vascular interventional robot.
    Biomed Microdevices 2018 Feb 19;20(1):20. Epub 2018 Feb 19.
    Department of Interventional Neuroradiology, Beijing Engineering Technology Research Center for Interventional Neuroradiology, and Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, 10050, China.
    Remote-controlled vascular interventional robots (RVIRs) are being developed to increase the overall accuracy of surgical operations and reduce the occupational risks of intervening physicians, such as radiation exposure and chronic neck/back pain. Several RVIRs have been used to operate catheters or guidewires accurately. However, a lack of cooperation between the catheters and guidewires results in the surgeon being unable to complete complex surgery by propelling the catheter/guidewire to the target position. Read More

    Finite element analysis of hollow out-of-plane HfO microneedles for transdermal drug delivery applications.
    Biomed Microdevices 2018 Feb 17;20(1):19. Epub 2018 Feb 17.
    Department of Physics & Nanotechnology, SRM University, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
    Transdermal drug delivery (TDD) based on microneedles is an excellent approach due to its advantages of both traditional transdermal patch and hypodermic syringes. In this paper, the fabrication method of hollow out-of-layer hafnium oxide (HfO) microneedles mainly based on deep reactive ion etching of silicon and atomic layer deposition of HfO is described, and the finite element analysis of the microneedles based on ANSYS software is also presented. The fabrication process is simplified by using a single mask. Read More

    Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis.
    Biomed Microdevices 2018 Feb 14;20(1):18. Epub 2018 Feb 14.
    Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
    Bioreactors are systems that can be used to monitor the response of tissues and cells to candidate drugs. Building on the experience developed in the creation of an osteochondral bioreactor, we have designed a new 3D printed system, which allows optical access to the cells throughout testing for in line monitoring. Because of the use of 3D printing, the fluidics could be developed in the third dimension, thus maintaining the footprint of a single well of a typical 96 well plate. Read More

    Simulative design in macroscale for prospective application to micro-catheters.
    Biomed Microdevices 2018 Feb 9;20(1):17. Epub 2018 Feb 9.
    Department of Mechanical Engineering, Korea Advanced Institute of Science & Technology (KAIST), Science Town, Daejeon, 305-701, South Korea.
    In this paper, a motion-transforming element is applied to the development of a new catheter device. The motion-transforming element structure allows a reduction of linear movement and converts linear movement to rotational movement. The simulative design of micro-catheters is based on a proposed structure called the Operating Mini Station (OMS). Read More

    Correction to: Development of micro mechanical device having two-dimensional array of micro chambers for cell stretching.
    Biomed Microdevices 2018 Feb 9;20(1):16. Epub 2018 Feb 9.
    Graduate School of Sciences and Technology for Innovation, Yamaguchi University, 2-6-1 Tokiwadai, Ube, Yamaguchi, 755-8611, Japan.
    The original article has been corrected. Instances of the character "μ" should be replaced by the term "micro". Read More

    Rapid enumeration of CD4 + T lymphocytes using an integrated microfluidic system based on Chemiluminescence image detection at point-of-care testing.
    Biomed Microdevices 2018 Feb 8;20(1):15. Epub 2018 Feb 8.
    Institute of Micro/Nanotechnology, Old Dominion University, Norfolk, VA, 23529, USA.
    An integrated microfluidic system has been developed for rapid enumeration of CD4 + T lymphocytes at point-of-care (POC) settings. A concise microfluidic chip, which consists of three separate chambers, respectively, for reaction, detection and waste storage, is developed to automate CD4 detection. To simplify CD4 + T lymphocyte enumeration, a single polycarbonate bead immobilized with CD4 antibody is adopted by the microfluidic chip to capture the CD4 antigen in the lysed testing sample. Read More

    Portable low-power thermal cycler with dual thin-film Pt heaters for a polymeric PCR chip.
    Biomed Microdevices 2018 Jan 29;20(1):14. Epub 2018 Jan 29.
    Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Republic of Korea.
    Polymerase chain reaction (PCR) has been widely used for major definite diagnostic tool, but very limited its place used only indoor such as hospital or diagnosis lab. For the rapid on-site detection of pathogen in an outdoor environment, a low-power cordless polymerase chain reaction (PCR) thermal cycler is crucial module. At this point of view, we proposed a low-power PCR thermal cycler that could be operated in an outdoor anywhere. Read More

    Stromalized microreactor supports murine hematopoietic progenitor enrichment.
    Biomed Microdevices 2018 Jan 20;20(1):13. Epub 2018 Jan 20.
    Department of Surgery, Center for Surgery, Innovation, & Bioengineering, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, MA, 02114, USA.
    There is an emerging need to process, expand, and even genetically engineer hematopoietic stem and progenitor cells (HSPCs) prior to administration for blood reconstitution therapy. A closed-system and automated solution for ex vivo HSC processing can improve adoption and standardize processing techniques. Here, we report a recirculating flow bioreactor where HSCs are stabilized and enriched for short-term processing by indirect fibroblast feeder coculture. Read More

    2DEP cytometry: distributed dielectrophoretic cytometry for live cell dielectric signature measurement on population level.
    Biomed Microdevices 2018 Jan 8;20(1):12. Epub 2018 Jan 8.
    New Technologies for the Information Society European Centre of Excellence, University of West Bohemia, 30614, Pilsen, Czech Republic.
    In this work, a novel force equilibrium method called distributed dielectrophoretic cytometry (2DEP cytometry) was developed. It uses a dielectrophoresis (DEP)-induced vertical translation of live cells in conjunction with particle image velocimetry (PIV) in order to measure probabilistic distribution of DEP forces acting on an entire cell population. The method is integrated in a microfluidic device. Read More

    Finite element modeling to analyze TEER values across silicon nanomembranes.
    Biomed Microdevices 2018 Jan 5;20(1):11. Epub 2018 Jan 5.
    Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY, 14627, USA.
    Silicon nanomembranes are ultrathin, highly permeable, optically transparent and biocompatible substrates for the construction of barrier tissue models. Trans-epithelial/endothelial electrical resistance (TEER) is often used as a non-invasive, sensitive and quantitative technique to assess barrier function. The current study characterizes the electrical behavior of devices featuring silicon nanomembranes to facilitate their application in TEER studies. Read More

    Development of micro mechanical device having two-dimensional array of micro chambers for cell stretching.
    Biomed Microdevices 2018 Jan 5;20(1):10. Epub 2018 Jan 5.
    Graduate School of Sciences and Technology for Innovation, Yamaguchi University, 2-6-1 Tokiwadai, Ube, Yamaguchi, 755-8611, Japan.
    This paper presents a novel cell stretching micro device having two-dimensional array of micro chambers. It enables an in situ time-lapse observation of stretched cell by using an optical microscope with high measurement efficiency. The presented device consists of a cell culture dish and the array of micro chambers made of silicone elastomer and extension structures made of photocurable resin, and is fabricated with MEMS technology. Read More

    Structuring a multi-nodal neural network in vitro within a novel design microfluidic chip.
    Biomed Microdevices 2018 Jan 2;20(1). Epub 2018 Jan 2.
    Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
    Neural network formation is a complex process involving axon outgrowth and guidance. Axon guidance is facilitated by structural and molecular cues from the surrounding microenvironment. Micro-fabrication techniques can be employed to produce microfluidic chips with a highly controlled microenvironment for neural cells enabling longitudinal studies of complex processes associated with network formation. Read More

    Two-photon fabrication of hydrogel microstructures for excitation and immobilization of cells.
    Biomed Microdevices 2017 Dec 29;20(1). Epub 2017 Dec 29.
    Institute of Applied Physics, University of Münster, Münster, 48149, Germany.
    We investigate in vitro fabrication of hydrogel microstructures by two photon laser lithography for single cell immobilization and excitation. Fluorescent yeast cells are embedded in water containing the hydrogel precursor mixtures and cross-linking is used to selectively immobilize a particular cell. Cell viability within the hydrogel precursor is estimated using a life/dead assay and elastic and stiff hydrogel structures are fabricated, immobilizing cells in a microfluidic environment. Read More

    Lab-on-a-chip device made by autohesion-bonded polymers.
    Biomed Microdevices 2017 Dec 18;20(1). Epub 2017 Dec 18.
    Regenerative Medicine Institute (REMEDI) and CÚRAM Centre for Research in Medical, Galway, Ireland.
    Polymers have the obvious advantages of flexibility in design and cost effectiveness to fabricate a lab-on-a-chip (LOC) device. Polyether ether ketone (PEEK) in particular is very attractive choice as it adds biocompatibility in addition to the possibility of hematic sealing in a 3D design. Hereby, we extend our previous successful technology of autohesive hermetic bonding of medical implants into lab-on-a-chip devices. Read More

    A Radial Pillar Device (RAPID) for continuous and high-throughput separation of multi-sized particles.
    Biomed Microdevices 2017 Nov 28;20(1). Epub 2017 Nov 28.
    Indian Institute of Technology Bombay, Mumbai, India.
    Pillar-based microfluidic sorting devices are preferred for isolation of rare cells due to their simple designs and passive operation. Dead-end pillar filters can efficiently capture large rare cells, such as, circulating tumor cells (CTCs), nucleated red blood cells (NRBCs), CD4 cells in HIV patients, etc., but they get clogged easily. Read More

    Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract.
    Biomed Microdevices 2017 Nov 27;20(1). Epub 2017 Nov 27.
    Department of Immunology, Chair of Clinical Immunology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806, Poznan, Poland.
    The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. Read More

    A novel fabrication method of carbon electrodes using 3D printing and chemical modification process.
    Biomed Microdevices 2017 Nov 23;20(1). Epub 2017 Nov 23.
    Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA.
    Three-dimensional (3D) printing is an emerging technique in the field of biomedical engineering and electronics. This paper presents a novel biofabrication method of implantable carbon electrodes with several advantages including fast prototyping, patient-specific and miniaturization without expensive cleanroom. The method combines stereolithography in additive manufacturing and chemical modification processes to fabricate electrically conductive carbon electrodes. Read More

    A novel photodynamic therapy-based drug delivery system layered on a stent for treating cholangiocarcinoma.
    Biomed Microdevices 2017 Nov 22;20(1). Epub 2017 Nov 22.
    Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
    This study aimed to investigate the drug delivery efficacy and bio-effectiveness of a novel photodynamic therapy (PDT)-matrix drug delivery system for cholangiocarcinoma (CCA). Metallic stents were coated with polyurethane (PU) as the first layer. A 2-hydroxyethyl methacrylate (2-HEMA)/ethylene glycol dimethacrylate (EGDMA)/benzoyl peroxide (BPO) layer and a poly(ethylene-co-vinyl acetate) (PEVA)/poly(n-butyl methacrylate) (PBMA)/polyvinylpyrrolidone K30 (K30) layer containing various concentrations of Photofrin were then incorporated onto the stent as the second and third layers. Read More

    Full-wafer in-situ fabrication and packaging of microfluidic flow cytometer with photo-patternable adhesive polymers.
    Biomed Microdevices 2017 Nov 21;20(1). Epub 2017 Nov 21.
    imec, Kapeldreef 75, B-3001, Leuven, Belgium.
    Integration of microelectronics with microfluidics enables sophisticated lab-on-a-chip devices for sensing and actuation. In this paper, we investigate a novel method for in-situ microfluidics fabrication and packaging on wafer level. Two novel photo-patternable adhesive polymers were tested and compared, PA-S500H and DXL-009. Read More

    Molybdenum coated SU-8 microneedle electrodes for transcutaneous electrical nerve stimulation.
    Biomed Microdevices 2017 Nov 21;20(1). Epub 2017 Nov 21.
    Biomedical Engineering, Graduate Program, University of Manitoba, Winnipeg, Manitoba, Canada.
    Electrophysiological devices are connected to the body through electrodes. In some applications, such as nerve stimulation, it is needed to minimally pierce the skin and reach the underneath layers to bypass the impedance of the first layer called stratum corneum. In this study, we have designed and fabricated surface microneedle electrodes for applications such as electrical peripheral nerve stimulation. Read More

    Irreversible electroporation of the uterine cervix in a rabbit model.
    Biomed Microdevices 2017 Nov 14;19(4):103. Epub 2017 Nov 14.
    Guangzhou Fuda Cancer Institute, Fuda Cancer Hospital, Jinan University School of Medicine, No. 2, Tangdexi Road, Tianhe District, Guangzhou, Guangdong Province, 510665, China.
    The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the uterine cervix in a rabbit model. IRE ablation was performed in the cervices of 48 New Zealand rabbits, with one ablation lesion in each animal. Gross pathology, transmission electron microscopy, hematoxylin and eosin (H&E), Masson's trichrome (MT) stain, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed at pre-set time points (0 h, 12 h, 1 d, 2 d, 4 d, 7 d, 14 d, and 28 d post-IRE). Read More

    Engineered bone scaffolds with Dielectrophoresis-based patterning using 3D printing.
    Biomed Microdevices 2017 Nov 13;19(4):102. Epub 2017 Nov 13.
    Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong.
    Patterning of cells into a specific pattern is an important procedure in tissue engineering to facilitate tissue culture and ingrowth. In this paper, a new type of 3D-printed scaffold utilizing dielectrophoresis (DEP) for active cell seeding and patterning was proposed. This scaffold adopted a concentric-ring design that is similar to native bone tissues. Read More

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