1,490 results match your criteria Biomedical Materials[Journal]


Calcium phosphate nanoparticles as intrinsic inorganic antimicrobials: mechanism of action.

Biomed Mater 2020 Jul 3. Epub 2020 Jul 3.

Division of Biomaterials and Biomedical Engineering, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA, San Francisco, UNITED STATES.

This is the final report of the study aimed at assessing the antimicrobial activity of CP nanoparticles delivered in the form of hydroxyapatite (HAp) or amorphous CP (ACP) and understanding the fundamental principles behind their mechanisms of action. Not responding to propidium iodide and causing no gross morphological changes except moderate stress-induced filamentation in E. coli, CP nanoparticles were shown to be bacteriostatic, not bactericidal. Read More

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http://dx.doi.org/10.1088/1748-605X/aba281DOI Listing

Reduction of fibrous encapsulation by polyethylene glycol-grafted liposomes containing phosphatidylserine.

Biomed Mater 2020 Jul 2. Epub 2020 Jul 2.

Department of Dental Biomaterials Science, Seoul National University, School of Dentistry, 101 Daehak-ro, Jongno-ku, Seoul, 03080, Korea (the Republic of).

Biomedical implants tend to induce fibrous encapsulation which can cause malfunction of devices and local discomfort of patients. The purpose of this study was to reduce foreign body-induced fibrous capsule formation by immunomodulation of macrophages. Polyethylene glycol-grafted liposomes containing phosphatidylserine (PEG-PSLs) were used to modulate macrophages. Read More

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http://dx.doi.org/10.1088/1748-605X/aba238DOI Listing

Tough pNAGA hydrogel hybridized porcine pericardium for the pre-mounted TAVI valve with improved anti-tearing properties and hemocompatibility.

Biomed Mater 2020 Jul 2. Epub 2020 Jul 2.

Sichuan University, Chengdu, CHINA.

The rate of transcatheter aortic valve implantation (TAVI) adoption grows rapidly due to the less-invasive procedure. However, TAVI still faces durability problem, potential incidence of thrombosis, and inconvenience of storage in glutaraldehyde (Glut) solution. In this work, a tough hydrogel (poly N-acryloyl glycinamide, pNAGA) was hybridized with Glut crosslinked porcine pericardium (Glut-PP) through in situ polymerization and glycerolization to obtain dry leafet material for the fabrication of pre-mounted bioprosthetic heart valve. Read More

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http://dx.doi.org/10.1088/1748-605X/aba239DOI Listing

Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium.

Biomed Mater 2020 Jul 2. Epub 2020 Jul 2.

Central Electrochemical Research Institute CSIR, Karaikudi, Tamil Nadu, INDIA.

Surface modified commercially pure titanium with Zr based thin film metallic glasses (Zr-TFMGs) and ZrO2 thin films were surgically implanted into tibia of rat; the bone formation was analyzed to examine the performance of the coatings as a biomaterial. Zr-TFMGs and ZrO2 thin films were coated on Cp-Ti substrates to monitor the control of assimilation in vitro and in vivo. The microstructural and elemental analyses were carried out for the as deposited thin films by X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy. Read More

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http://dx.doi.org/10.1088/1748-605X/aba23aDOI Listing

Development of fibrous PLGA/fibrin scaffolds as a potential skin substitute.

Biomed Mater 2020 Jun 26. Epub 2020 Jun 26.

Hematology and Stem Cell Laboratory, Universidade Federal do Rio Grande do Sul Faculdade de Farmacia, Porto Alegre, BRAZIL.

The aim of this study has been to fabricate a hybrid electrospun nanofibrous scaffold composed of PLGA/fibrin polymers to be used as a skin substitute and analyze its physical and biological properties. Fibrin (Fib) was obtained from rat blood plasma, characterized and solubilized in formic acid. The final electrospinning solution concentration was 40 % PLGA (w/v) and 1 % fibrin (w/v). Read More

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http://dx.doi.org/10.1088/1748-605X/aba086DOI Listing

A photoactivatable antibody-Chlorin e6 conjugate enabling singlet oxygen production for tumor targeting photodynamic therapy.

Biomed Mater 2020 Jun 25. Epub 2020 Jun 25.

The second affiliated Hospital of Xi'an Medical University, XI'AN, CHINA.

Photodynamic therapy (PDT) is a new technology for disease diagnosis and treatment in modern medical clinic. The main advantages of PDT are low toxicity and side effects, wide range of application, no drug resistance, and no obvious trauma in the treatment process. However, in order to achieve effective PDT, new photosensitizer carriers need to be constructed, which can selectively deliver PS into tumor tissues. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9f57DOI Listing

Collagen particle with collagen-binding bone morphogenetic protein-2 promotes vertebral laminar regeneration in infant rabbits.

Biomed Mater 2020 Jun 24. Epub 2020 Jun 24.

Chinese Academy of Sciences - Institute of Genetics and Developmental Biology, No 1 West Beichen Road, Chaoyang District, Beijing, 100101, Beijing, Beijing, CHINA.

The vertebral laminar defects caused by severe spina bifida occulta, spinal fracture, or bone tuberculosis require surgical treatment. The reconstruction of vertebral laminar defects remains challenging, especially in children. In this study, we created an animal model of vertebral laminar defects in newly weaned rabbits to evaluate the therapeutic effect of bovine bone collagen particle (BBCP) that combined with bone morphogenetic protein-2 with collagen binding domain (CBD-BMP-2). Read More

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http://dx.doi.org/10.1088/1748-605X/ab9fceDOI Listing
June 2020
3.697 Impact Factor

An extracellular matrix-mimicking, bilayered, heterogeneous, porous, nanofibrous scaffold for anterior urethroplasty in a rabbit model.

Biomed Mater 2020 Jun 24. Epub 2020 Jun 24.

Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, CHINA.

Anterior urethral reconstruction is still a challenging clinical task, and tissue engineering technology offers new options for anterior urethroplasty. In this work, we evaluated an extracellular matrix (ECM) mimicking scaffold for anterior urethral reconstruction in a New Zealand white rabbit model. After the creation of a urethral defect, the extracellular matrix-mimicking scaffold was applied in 6 rabbits, and small intestinal submucosa was used in 3 rabbits. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9fd0DOI Listing

Controlled degradation of chitosan coated strontium-doped calcium sulfate hemihydrate composite cement promotes bone defect repair in osteoporosis rats.

Biomed Mater 2020 Jun 24. Epub 2020 Jun 24.

School of Medicine, South China University of Technology, Guangzhou, CHINA.

Strontium-doped calcium sulfate hemihydrate (SrCSH) bioactive materials have shown the role of promoting osteoporotic bone repair, being associated with the stimulation of bone formation and a reduction in bone resorption. However, the rapid degradation and absorption of SrCSH affects its clinical value. In order to delay the degradation time of SrCSH and improve the utilization of Sr2+, chitosan coated SrCSH microspheres (CS-SrCSH) were prepared by electrostatic interaction between chitosan and SrCSH. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9fcfDOI Listing

Tyrosinase-crosslinked, tissue adhesive and biomimetic alginate sulfate hydrogels for cartilage repair.

Biomed Mater 2020 Jun 24;15(4):045019. Epub 2020 Jun 24.

Tissue Engineering and Biofabrication Laboratory, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland. School of Medicine, Koç University, Rumelifeneri Yolu, Istanbul 34450, Turkey. Koç University, Research Center for Translational Medicine, Rumelifeneri Yolu, Istanbul 34450, Turkey.

The native cartilage extracellular matrix (ECM) is enriched in sulfated glycosaminoglycans with important roles in the signaling and phenotype of resident chondrocytes. Recapitulating the key ECM components within engineered tissues through biomimicking strategies has potential to improve the regenerative capacity of encapsulated cells and lead to better clinical outcome. Here, we developed a double-modified, biomimetic and tissue adhesive hydrogel for cartilage engineering. Read More

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http://dx.doi.org/10.1088/1748-605X/ab8318DOI Listing

Marine collagen-chitosan-fucoidan cryogels as cell-laden biocomposites envisaging tissue engineering.

Biomed Mater 2020 Jun 22. Epub 2020 Jun 22.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, PT 4805-017, PORTUGAL.

The combination of marine origin biopolymers for tissue engineering (TE) applications is of high interest, due to their similarities with the proteins and polysaccharides present in the extracellular matrix of different human tissues. This manuscript reports on innovative collagen-chitosan-fucoidan cryogels formed by the simultaneous blending of these 3 marine polymers in a chemical-free cross-linking approach. The physicochemical characterization of marine biopolymers comprised FTIR, Amino Acids analysis, CD and, SDS-PAGE, and suggested that the jellyfish collagen used in the cryogels was not denatured (preserved the triple helical structure) and had similarities with type II collagen. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9f04DOI Listing

In vitro and in vivo evaluation of antibacterial activity of polyhexamethylene guanidine (PHMG)-loaded TiO nanotubes.

Biomed Mater 2020 Jun 22;15(4):045016. Epub 2020 Jun 22.

Department of Orthopedics, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, People's Republic of China. Department of Orthopedics and Rehabilitation, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou Hospital of Zhejiang University, Huzhou 313000, People's Republic of China. These authors contributed equally to this article.

Artificial joint replacement is an effective surgical method for treating end-stage degenerative joint diseases, but peripheral bacterial infection of prosthesis can compromise the effect of the surgery. Herein, antibacterial effects of titanium dioxide nanotubes (TNTs) coated with polyhexamethylene guanidine (PHMG) were examined via in vitro and in vivo experiments. TNTs with a pore diameter 46. Read More

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http://dx.doi.org/10.1088/1748-605X/ab7e79DOI Listing

Mechanically strengthened hybrid peptide-polyester hydrogel and potential application in spinal cord injury repair.

Biomed Mater 2020 Jun 18. Epub 2020 Jun 18.

PCFM Lab, GD HPPC Lab, School of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong, CHINA.

RADA16 peptide hydrogels have been broadly used in tissue engineering due to their good biocompatibility and nanofibrous structure mimicking the native extracellular matrix (ECM). However, the low mechanical strength often fails them as implantable scaffolds. To improve the mechanical stability of RADA16 peptide hydrogel, a photocrosslinkable diacrylated poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) triblock copolymer (PCECDA) was physically combined with RADA16 peptide pre-modified with cell adhesive Arg-Gly-Asp sequence (RADA16-RGD). Read More

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http://dx.doi.org/10.1088/1748-605X/ab9e45DOI Listing

Photoactivated platelet rich plasma (PRP) based patient-specific bio-ink for cartilage tissue engineering.

Biomed Mater 2020 Jun 18. Epub 2020 Jun 18.

Chemical Engineering Department Bioengineering Division, Hacettepe Universitesi, Beytepe, 06532 Ankara, Ankara, TURKEY.

Nowadays, scientists focus on the development of tissue-specific and personalized bio-ink that can be used in 3D bioprinting technologies. Platelet-rich plasma (PRP) is a person-specific source that is used as a therapeutic for the cure of cartilage damage because it offers a cocktail of growth factors that are necessary for tissue regeneration. However, PRP treatments in clinic is not satisfactory and requires to be upgraded, especially the point of maintaining bioactivity. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9e46DOI Listing

Preparation of smooth and macroporous hydrogel via hand-held blender for wound healing applications: in-vitro and in-vivo evaluations.

Biomed Mater 2020 Jun 16. Epub 2020 Jun 16.

Northwest University, Xi'an, CHINA.

Wound dressings play an indispensable role in wound healing. However, traditional wound dressings have several disadvantages, such as poor mechanical properties and small pore diameters, which do not allow sufficient gas exchange. To overcome these shortcomings, this paper reports a polyvinyl alcohol (PVA)-based hydrogel physically crosslinked at -20 °C and containing polyethylene glycol (PEG) and nanohydroxyapatite (HAP). Read More

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http://dx.doi.org/10.1088/1748-605X/ab9d6fDOI Listing
June 2020
3.697 Impact Factor

Going beyond RGD: screening of a cell-adhesion peptide library in 3D cell culture.

Biomed Mater 2020 Jun 16. Epub 2020 Jun 16.

Institute for Macromolecular Chemistry, Albert-Ludwigs-Universitat Freiburg, Stefan-Meier-Str. 31, Freiburg im Breisgau, 79085, GERMANY.

In tissue engineering, cell-adhesion peptides (CAPs) such as the ubiquitous arginine-glycine-aspartic acid (RGD) sequence have allowed the functionalization of synthetic materials to mimic macromolecules of the extracellular matrix (ECM). However, the variety of ECM macromolecules makes it challenging to reproduce all of the native tissue functions with only a limited variety of CAPs. Screening of libraries of CAPs, analogous to high-throughput drug discovery assays, can help to identify new sequences directing cell organisation. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9d6eDOI Listing

Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan-g-methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer.

Biomed Mater 2020 Jun 11. Epub 2020 Jun 11.

Department of Ophthalmology, Chosun University, Gwangju, Gwangju, Korea (the Republic of).

The aim of this study is to prepare reactive oxygen species (ROS)-sensitive nanophotosensitizers for targeted delivery of chlorin e6 (Ce6) and photodynamic therapy of tumor. For this purpose, thiodipropionic acid (TDPA) was conjugated with phenyl boronic acid pinacol ester (PBAP) (TDPA-PBAP conjugates) and then TDPA-PBAP conjugates were attached to the chitosan backbone of chitosan-g-methoxy poly(ethylene glycol) (ChitoPEG) copolymer (ChitoPEG-PBAP). Ce6-incorporated ChitoPEG-PBAP nanophotosensitizers have a ROS-sensitive manner in vitro. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9bb2DOI Listing

Concurrent multi-lineage differentiation of mesenchymal stem cells through spatial presentation of growth factors.

Biomed Mater 2020 Jun 11. Epub 2020 Jun 11.

Fischell Department of Bioengineering, University of Maryland, 4104A Clark Hall, College Park, MD 20742, USA, College Park, Maryland, UNITED STATES.

Severe tendon and ligament injuries are estimated to affect between 300,000 and 400,000 people annually. Surgical repairs of these injuries often have poor long-term clinical outcomes because of resection of the interfacial tissue - the enthesis - and subsequent stress concentration at the attachment site. A healthy enthesis consists of distinct regions of bone, fibrocartilage, and tendon, each with distinct cell types, extracellular matrix components, and architecture, which are important for tissue function. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9bb0DOI Listing

Electrospun PCL-based nanofibers Arrabidaea chica Verlot - Pterodon pubescens Benth loaded: synergic effect in fibroblast formation.

Biomed Mater 2020 Jun 11. Epub 2020 Jun 11.

Faculdade de Engenharia Mecânica, UNICAMP, Campinas, SP, BRAZIL.

The Guided Tissue Regeneration (GTR) technique can be applied in dentistry and other medical specializations, such as orthopedics. In modern dentistry, GTR has been used in periodontics and implantology to treat periodontal defects, reconstruct lost, damaged and atrophied bone tissue in dental implant procedures or to preserve as alveolar bases after tooth extraction. In order to create and improve new therapies and/or to develop new biomaterials that restore, improve or prevent aggravation of compromised tissue function, poly (ε-caprolactone) (PCL) polymer membranes obtained by the electrospinning process were associated with two plant extracts, Pterodon pubescens Benth (P. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9bb1DOI Listing

In vitro characterization of osteoblast cells on polyelectrolyte multilayers containing detonation nanodiamonds.

Biomed Mater 2020 Jun 11. Epub 2020 Jun 11.

School of Integrated Technology, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 406-840, Korea (the Republic of).

Nanoparticle-enhanced coatings of bone implants are a promising method to facilitate sustainable wound healing, leading to an increase in patient well-being. This article describes the in vitro characterization of osteoblast cells interacting with polyelectrolyte multilayers, which contain detonation nanodiamonds (NDs), as a novel class of carbon-based coating material, which presents a unique combination of photoluminescence and drug-binding properties. The cationic polyelectrolyte, namely polydiallyldimethylammonium chloride (PDDA), has been used to immobilize NDs on silica glass. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9bafDOI Listing

A printing-spray-transfer process for attaching biocompatible and antibacterial coatings to the surfaces of patient-specific silicone stents.

Biomed Mater 2020 Jun 5. Epub 2020 Jun 5.

Zhejiang University, Hangzhou, 310058, CHINA.

An antibacterial coating with stable antibacterial properties and favorable biocompatibility is recognized as an effective method to prevent bacterial adhesion and biofilm formation on biomedical implant surfaces. In this study, a convenient and low-cost printing-spray-transfer process was proposed that enables reliably attaching antibacterial and biocompatible coatings to patient-specific silicone implant surfaces. A desktop three-dimensional printer was used to print the mold of silicone implant molds according to the characteristics of the diseased areas. Read More

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http://dx.doi.org/10.1088/1748-605X/ab99d6DOI Listing

Frontiers in urethra regeneration: current state and future perspective.

Biomed Mater 2020 Jun 5. Epub 2020 Jun 5.

Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, UNITED STATES.

Despite the positive achievements attained, the treatment of male urethral strictures and hypospadiases still remains a challenge, particularly, in cases of severe urethral defects. Complication rate and need for additional interventions in such cases are the highest. Also, shortage of autologous tissue for graft harvesting and significant morbidity on the place of harvesting present a problem and often lead to staged treatment. Read More

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http://dx.doi.org/10.1088/1748-605X/ab99d2DOI Listing

Co-effects of C/Ag dual ion implantation on enhancing antibacterial ability and biocompatibility of silicone rubber.

Biomed Mater 2020 Jun 5. Epub 2020 Jun 5.

Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Xinqiao Road, Sha Ping Ba District, Chongqing, 400037, People's Republic of China., Chongqing, 400038, CHINA.

Although silicone implants are the most popular choice around the world for breast augmentation, reconstruction, and revision, due to the poor antibacterial properties and limited biocompatibility of silicone rubber (SR), one of the major complications, capsule contracture, is a lingering problem. To overcome the two main shortcomings, dual ion implantation technique was applied to modify the surface of SR with the basic skeleton element of organic matters, carbon (C) and the broad-spectrum bactericide, silver (Ag). We present surface characterization, toxicological effects, and evaluation of the mechanical, antibacterial and biocompatible properties of C and Ag co-implanted SR (C/Ag-SRs). Read More

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http://dx.doi.org/10.1088/1748-605X/ab99d3DOI Listing
June 2020
3.697 Impact Factor

Preclinical evaluation of a mini-arthroplasty implant based on polyetheretherketone and Ti6AI4V for treatment of a focal osteochondral defect in the femoral head of hip.

Biomed Mater 2020 Jun 4. Epub 2020 Jun 4.

Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, 200127, CHINA.

A mini or partial arthroplasty may offer the advantages of reduced pain, shorter hospital stay, and increased range of motion, which are beneficial for the treatment of large-sized focal osteochondral defects. We aimed to evaluate the in vivo histologic response and function of our nonresorbable, composite structure implant, developed using polyetheretherketone (PEEK) and Ti6AI4V alloy, as a treatment for full-thickness osteochondral defects in the femoral head of the hip using a goat model. The gross and imaging appearance and histologic results were compared to those of a similar size cobalt-chromium-molybdenum (CoCrMo) alloy implant placed in a defect in the femoral head and evaluated up to 12 weeks. Read More

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http://dx.doi.org/10.1088/1748-605X/ab998aDOI Listing
June 2020
3.697 Impact Factor

A comparative study of materials assembled from recombinant K31 and K81 and extracted human hair keratins.

Biomed Mater 2020 Jun 2. Epub 2020 Jun 2.

Chemistry, Virginia Tech, Blacksburg, Virginia, UNITED STATES.

Natural biopolymers have found success in tissue engineering and regenerative medicine applications. Their intrinsic biocompatibility and biological activity make them well suited for biomaterials development. Specifically, keratin-based biomaterials have demonstrated utility in regenerative medicine applications including bone regeneration, wound healing, and nerve regeneration. Read More

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http://dx.doi.org/10.1088/1748-605X/ab98e8DOI Listing

3D printed insert-array and 3D-coculture-array for high-throughput screening of cell migration and application to study molecular and cellular influences.

Biomed Mater 2020 Jun 2. Epub 2020 Jun 2.

Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, UNITED STATES.

Collective cell migration refers to the movement of groups of cells and collective cell behavior and relies on cell-cell communication and cell-environment interactions. Collective cell migration plays a fundamental role in many aspects of cell biology and pathology. Current protocols for studying collective cell migration either use destructive methods or are not convenient for liquid handling. Read More

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http://dx.doi.org/10.1088/1748-605X/ab98e9DOI Listing

Zirconia-containing wollastonite ceramics derived from bio waste resources for bone tissue engineering.

Biomed Mater 2020 May 28. Epub 2020 May 28.

Biochemistry, University of Hyderabad School of Life Sciences, Hyderabad, Telangana, INDIA.

Zirconia - containing wollastonite (CaSiO3) ceramics with partial substitution of zirconia (1, 3 and 5 mol%) were prepared using eggshells and rice husk ash (RHA) as source materials for calcium oxide and silica respectively through sol-gel technique. The effect of zirconia incorporation on in vitro bioactivity, mechanical properties, degradability and cytocompatibility of wollastonite was studied. Bioactivity was evaluated by in vitro assay using simulated body fluid (SBF) while degradability was tested in Tris-HCl buffer solution for different time periods (1, 3, 7, 14 and 21 days) according to ISO 10993-14 standard. Read More

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http://dx.doi.org/10.1088/1748-605X/ab975dDOI Listing
May 2020
3.697 Impact Factor

3D hepatic mimics - the need for a multicentric approach.

Biomed Mater 2020 May 27. Epub 2020 May 27.

Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, Telangana, INDIA.

The liver is a center of metabolic activity including the metabolism of drugs and consequently is prone to drug-induced liver injury. Failure to detect hepatotoxicity of drugs during their development will lead to post-release withdrawal of the drug from the market. To avoid such clinical and economic consequences, in vitro liver models that can accurately predict the toxicity of a drug during the pre-clinical phase is necessary. Read More

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http://dx.doi.org/10.1088/1748-605X/ab971cDOI Listing

Targeted drug delivery systems: synthesis and in-vitro bioactivity and apoptosis studies of gemcitabine-carbon dots conjugates.

Biomed Mater 2020 May 22. Epub 2020 May 22.

Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Terengganu, Terengganu, MALAYSIA.

Gemcitabine is used to treat various cancers like breast, pancreatic, non-small lung carcinoma, ovarian, bladder and cervical cancers. Gemcitabine (GEM), however, has the problems of non-selectivity. Water-soluble, fluorescent and mono-dispersed carbon dots (CDs) were fabricated using sucrose by ultrasonic method. Read More

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http://dx.doi.org/10.1088/1748-605X/ab95e1DOI Listing
May 2020
3.697 Impact Factor

A comparative study unraveling the effects of TNF-α stimulation on endothelial cells between 2D and 3D culture.

Biomed Mater 2020 May 22. Epub 2020 May 22.

Department of Pharmacology, Xi'an Jiaotong University, Xi'an, 710049, CHINA.

Endothelial cells (ECs) dysfunction is an important predictor of and contributor to the pathobiology of cardiovascular diseases. However, most in vitro studies are performed using monolayer cultures of ECs on 2D tissue polystyrene plates (TCPs), which cannot reflect the physiological characteristics of cells in vivo. Here, we used 2D TCPs and a 3D culture model to investigate the effects of dimensionality and cardiovascular risk factors in regulating endothelial dysfunction. Read More

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http://dx.doi.org/10.1088/1748-605X/ab95e3DOI Listing

3D cellular alignment and biomimetic mechanical stimulation enhance human adipose-derived stem cell myogenesis.

Biomed Mater 2020 May 22. Epub 2020 May 22.

BIOMATEN, METU Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, Ankara, Ankara, TURKEY.

Determination of a stem cell source with sufficient myogenic differentiation capacity that can be easily obtained in large quantities is of great importance in skeletal muscle regeneration therapies. Adipose-derived stem cells (ASCs) are readily available, can be isolated from fat tissue with high yield and possess myogenic differentiation capacity. Even though ASCs have high applicability in muscle regenerative therapies for these reasons, a key challenge is their low differentiation efficiency. Read More

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http://dx.doi.org/10.1088/1748-605X/ab95e2DOI Listing

Photo-crosslinked alginate nano-hydroxyapatite paste for bone tissue engineering.

Biomed Mater 2020 May 21. Epub 2020 May 21.

Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, 769008, INDIA.

In this study, methacrylation of alginate was carried out by reacting sodium alginate with methacrylic anhydride in the presence of sodium hydroxide (NaOH). Separately synthesized nano-hydroxyapatite (n-HA) powder was surface functionalized using mercaptopropionic acid (MPA) and EGMP (Ethylene Glycol Methacrylate Phosphate) in the presence of Azobisisobutyronitrile benzene (AIBN) as a free radical initiator in a nitrogen atmosphere. Methacrylated alginate solution was mixed with the required amount of surface functionalized HAp nanoparticles in the presence of 0. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9551DOI Listing

Dual phase scaffold produced by rotary jet spinning and electrospinning for tendon tissue engineering.

Biomed Mater 2020 May 21. Epub 2020 May 21.

Department of Engineering Sciences and Graduate Department of Biomedical Engineering, Middle East Technical University, Ankara, Ankara, TURKEY.

Tendon is a highly hierarchical and oriented tissue that bears high mechanical strength. Tendon injuries lead to loss of function, disability, and decrease in life quality. Limited healing capacity of tendon tissue leads to scar tissue formation which can affect mechanical strength and cause a retear. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9550DOI Listing

Effect of Irgacure 2959 and lithium phenyl-2,4,6-trimethylbenzoylphosphinate on cell viability, physical properties, and microstructure in 3D bioprinting of vascular-like constructs.

Biomed Mater 2020 May 21. Epub 2020 May 21.

Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, Texas, 79409, UNITED STATES.

Photocrosslinkable polymers such as gelatin methacrylate (GelMA) have various 3D bioprinting applications. These polymers crosslink upon exposure to UV irradiation with the existence of an appropriate photoinitiator. Two photoinitiators, Irgacure 2959 and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) are commonly used. Read More

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http://dx.doi.org/10.1088/1748-605X/ab954eDOI Listing

Development of osteogenic chitosan/alginate scaffolds reinforced with silicocarnotite containing apatitic fibers.

Biomed Mater 2020 May 21. Epub 2020 May 21.

Life Science Engineering, University of Tehran Faculty of New Sciences and Technologies, Tehran, Iran (the Islamic Republic of).

The composite scaffolds of chitosan/alginate (CH-AL) reinforced by silicon-containing biphasic fibers were prepared through the freeze-drying method. The fibers were synthesized using a homogenous precipitation method under different reaction times and were characterized by XRD, FTIR, SEM, and ICP-OES. Fibers composed of two phases of hydroxyapatite and β-tricalcium phosphate (β-TCP) which remained the same once they were incorporated by 0. Read More

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http://dx.doi.org/10.1088/1748-605X/ab954fDOI Listing

3D-printed chitosan scaffolds modified with D-(+) raffinose and enriched with type IV collagen to improve epithelial cell colonization.

Biomed Mater 2020 May 21. Epub 2020 May 21.

Dep. Medicine and Surgery, University of Parma, Parma, PR, ITALY.

Tissue regeneration often requires the use of biocompatible resorbable scaffolds to support the ingrowth of cells from neighboring tissues into a localized tissue defect. Such scaffolds must possess surface molecular cues that stimulate cells to populate the device, the first necessary condition for the formation of a healthy tissue. Chitosan is a natural polymer that has long been tested in biomedical applications because of its high biocompatibility, which can be further increased by modifying its formulation, e. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9552DOI Listing

In vitro and in vivo testing of nanofibrous membranes doped with alaptide and L-arginine for wound treatment.

Biomed Mater 2020 May 20. Epub 2020 May 20.

Dept. of Biomaterials and Tissue Engineering, Institute of Physiology Czech Academy of Sciences, Praha, CZECH REPUBLIC.

We have prepared a candidate biocompatible construct for skin wound healing based on electrospun polycaprolactone (PCL) nanofibrous membranes. The membrane material was loaded either with L-arginine or with alaptide, or with a mixture of both bioactive components. Alaptide is a spirocyclic synthetic dipeptide, an analogue of melanocyte-stimulating hormone release-inhibiting factor. Read More

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http://dx.doi.org/10.1088/1748-605X/ab950fDOI Listing

Liposomal dexamethasone-moxifloxacin nanoparticles combinations with collagen/gelatin/alginate hydrogel for corneal infection treatment and wound healing.

Biomed Mater 2020 May 20. Epub 2020 May 20.

Chang Gung Medical College, Taoyuan, Taoyuan, TAIWAN.

Infectious keratitis is still one of the major causes of visual impairment and blindness, often affecting developing countries. Eye-drop therapy to reduce disease progression is the first line of treatment for infectious keratitis. The current limitations in controlling ophthalmic infections include rapid precorneal drug loss and the inability to provide long-term extraocular drug delivery. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9510DOI Listing

Dual drug-delivering polycaprolactone-collagen scaffold to induce early osteogenic differentiation and coupled angiogenesis.

Biomed Mater 2020 May 19;15(4):045008. Epub 2020 May 19.

Biomaterials & Biomimetics laboratory, School of Life Sciences, Central University of Gujarat, Gandhinagar, 382030 India.

Bone regeneration is a multi-step, overlapping process, in which angiogenesis and osteogenesis are the key players. Several attempts have been made to promote angiogenesis-coupled osteogenesis using scaffolding technology. However, the recreation of functional vasculature during bone regeneration is an unparalleled challenge. Read More

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http://dx.doi.org/10.1088/1748-605X/ab7978DOI Listing

Preparation and characterization of borosilicate bioglass incorporated sodium alginate composite wound dressing for accelerated full-thickness skin wound healing.

Biomed Mater 2020 May 18. Epub 2020 May 18.

Mechanical & Electronic Engineering, Nanchang University, Nanchang, 330031, CHINA.

Full-thickness skin injury is a serious and intractable clinical problem. Wound dressing is urgently needed to treat serious skin defects or induce skin reconstruction. For the first time, we demonstrated a borosilicate bioglass (BBG) incorporated sodium alginate (SA) wound dressing by a simple and effective technique for accelerated wound healing. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9421DOI Listing

Efficient regeneration of rat calvarial defect with gelatin-hydroxyapatite composite cryogel.

Biomed Mater 2020 May 18. Epub 2020 May 18.

Beijing University of Chemical Technology, Beijing, Beijing, CHINA.

To induce bone regeneration efficiently, a properly designed organic-inorganic composite scaffold is necessary and important. Gelatin-hydroxyapatite (HA) composite is a suitable choice for the purpose because it can resemble the chemical composition of natural bone tissue. The gelatin-HA composite can be implanted into bone defects as a hydrogel or cryogel, however, it is interesting to know the effect of their different morphology on inducing osteogenesis in vivo. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9422DOI Listing

The growth and development of Biomedical Materials.

Authors:
Jianwu Dai

Biomed Mater 2020 May 14;15(4):040201. Epub 2020 May 14.

Center for Regenerative Medicine, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.

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http://dx.doi.org/10.1088/1748-605X/ab816bDOI Listing

A combinatorial approach for spinal cord injury repair using multifunctional collagen-based matrices: development, characterization and impact on cell adhesion and axonal growth.

Biomed Mater 2020 May 12. Epub 2020 May 12.

Polymer engineering, Yalova University, Yalova, Yalova, TURKEY.

Spinal cord injury (SCI) is a devastating condition of the central nervous system (CNS), in which traditional treatments are largely ineffective due to the complex nature of the injured tissue. Therefore, biomaterial-based systems have been developed as possible alternative strategies to repair the damaged tissue. In the present study, we aimed to design bioactive agents loaded scaffolds composed of two layers with distinct physical properties to improve tissue regeneration. Read More

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http://dx.doi.org/10.1088/1748-605X/ab924dDOI Listing

A new method for the preparation of three-layer vascular stents: a preliminary study on the preparation of biomimetic three-layer vascular stents using a three-stage electrospun membrane.

Biomed Mater 2020 May 11. Epub 2020 May 11.

Department of Cardiothoracic Surgery, Shanghai Childrens Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, CHINA.

There is an urgent need to design a tissue-engineered vascular graft that exhibits good biocompatibility and sufficient mechanical strength to repair and facilitate regeneration of defective vascular tissue. It is generally accepted that multi-layer stents can be used to simulate the structure and function of natural blood vessels. Here, we developed a new three-layer tubular graft that is rolled from a single PLCL electrospun membrane. Read More

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http://dx.doi.org/10.1088/1748-605X/ab920aDOI Listing

In vitro effects of the co-release of icariin and strontium from bioactive glass submicron spheres on the reduced osteogenic potential of rat osteoporotic bone marrow mesenchymal stem cells.

Biomed Mater 2020 May 6. Epub 2020 May 6.

Department of Metallurgical Engineering and Materials, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BRAZIL.

Osteoporosis is a metabolic disease that affects bone tissue and is highly associated with bone fractures. Typical osteoporosis fracture treatments, such as bisphosphonates and hormone replacement, present important challenges because of their low bioavailability on the site of action. Options to overcome this issue are systems for the local release of therapeutic agents such as bioactive glasses containing therapeutic molecules and ions. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9095DOI Listing

Functionalization of 3D-printed titanium alloy orthopedic implants: a literature review.

Biomed Mater 2020 May 5. Epub 2020 May 5.

Department of Orthopedics, Peking University Third Hospital, Beijing, CHINA.

3D-printed titanium alloy orthopedic implants combine the dual advantages of 3D printing and titanium alloys implants, which not only have complex structures that cannot be manufactured by traditional techniques, but also inherit the excellent physical and chemical properties of titanium and its alloys, so they are widely used in the field of orthopedics in recent years. The inherent porous structure of 3D-printed implants and the original modification processes of titanium alloys provide the conditions for the functionalization of implants. To meet the needs of orthopedic surgeons and patients, functionalized implants with the ability of long-term stability promotion, anti-infection or anti-tumor have been developed, in which various methods of functionalization deserve to be summarized, compared and analyzed. Read More

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http://dx.doi.org/10.1088/1748-605X/ab9078DOI Listing

Tissue engineered vessel from a biodegradable electrospun scaffold stimulated with mechanical stretch.

Biomed Mater 2020 Apr 29. Epub 2020 Apr 29.

Surgery, South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, Texas, 78284-5799, UNITED STATES.

A tissue engineered vessel has the potential to provide an alternative small diameter vascular graft for patients with cardiovascular disease in need of surgical revascularization. In this study, a polyglycolic acid (PGA) electrospun scaffold seeded with human dermal fibroblasts was stimulated with circumferential mechanical stretch by a pulsatile perfusion system. The PGA scaffold was fabricated using a custom electrospinning set-up to co-electrospray a sacrificial polyethylene oxide microparticle to increase pore size and bulk porosity. Read More

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http://dx.doi.org/10.1088/1748-605X/ab8e98DOI Listing

Characterization of a customized 3D-printed cell culture system using clear, translucent acrylate that enables optical online monitoring.

Biomed Mater 2020 Apr 29. Epub 2020 Apr 29.

Institute of Technical Chemistry, Leibniz University Hanover, Hannover, GERMANY.

Cells are very sensitive to their direct environment - they place high demands, for example, on ambient culture medium, adjacent cell types, and the properties of surrounding material parts. As a result, mechanical and physical material properties - such as surface roughness, swelling, electrostatic effects, etc. - can all have a significant impact on cell behavior. Read More

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http://dx.doi.org/10.1088/1748-605X/ab8e97DOI Listing

Cellulose acetate-gelatin coated boron-bioactive glass biocomposite scaffolds for bone tissue engineering.

Biomed Mater 2020 Apr 27. Epub 2020 Apr 27.

Department of Engineering Sciences, Middle East Technical University, Ankara, TURKEY.

In this study, we aimed to prepare and characterize porous scaffolds composed of pure and boron oxide (B2O3) doped bioactive glass (BG) that were infiltrated by cellulose acetate-gelatin (CA-GE) polymer solution for bone tissue engineering applications. Composite scaffolds were cross-linked with glutaraldehyde (GTA) after polymer coating to protect the structural integrity of the polymeric coated scaffolds. The impact of B2O3 incorporation into BG-polymer porous scaffolds on cross-sectional morphology, porosity, mechanical properties, degradation, and bioactivity of the scaffolds was investigated. Read More

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http://dx.doi.org/10.1088/1748-605X/ab8d47DOI Listing

Induced neural stem cell differentiation on a drawn fiber scaffold-toward peripheral nerve regeneration.

Biomed Mater 2020 Apr 24. Epub 2020 Apr 24.

The Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, CHINA.

To achieve regeneration of long sections of damaged nerves, restoration methods such as direct suturing or autologous grafting can be inefficient. Solutions involving biohybrid implants, where neural stem cells are grown in vitro on an active support before implantation, have attracted attention. Using such an approach, combined with recent advancements in microfabrication technology, the chemical and physical environment of cells can be tailored in order to control their behaviors. Read More

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http://dx.doi.org/10.1088/1748-605X/ab8d12DOI Listing
April 2020
3.697 Impact Factor