1,327 results match your criteria Biomedical Materials[Journal]


Chitosan/Montmorillonite composite nanospheres for sustained antibiotic delivery at post-implantation bone infection treatment.

Biomed Mater 2019 Apr 16. Epub 2019 Apr 16.

Chemical Engineering, İzmir Institute of Techology, İzmir, TURKEY.

Despite the advancements in bone transplantation operations, inflammation is still a serious problem that threatens human health at the post-implantation period. Conventional antibiotic therapy methods may lead to some side effects such as ototoxicity and nephrotoxicity, especially when applied in high doses. Therefore, local drug delivery systems play a vital role in bone disorders due to the elimination of the disadvantages introduced by conventional methods. Read More

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http://dx.doi.org/10.1088/1748-605X/ab1a04DOI Listing

Printing in situ tissue sealant with visible-light-crosslinked porous hydrogel.

Biomed Mater 2019 Apr 16. Epub 2019 Apr 16.

Department of Mechanical and Aerospace Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Clayton, Victoria, 3800, AUSTRALIA.

To reflect the rapidly growing interest in producing tissue sealants using various chemical/physical processes, we report an approach using visible light to control the crosslinking of 3D printable hydrogels as in situ tissue sealant. Gelatin-hydroxyphenylpropionic acid conjugate (Gtn-HPA) is shown to crosslink effectively within 30 seconds under visible light in the presence of [RuII(bpy)3]2+ and sodium persulphate, which is sufficiently rapid for surgery use. Porous structure can be also introduced by including carboxylmethyl cellulose-tyramine (CMC-Tyr) as a precursor. Read More

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http://dx.doi.org/10.1088/1748-605X/ab19feDOI Listing

Influence of the PLGA/gelatin ratio on the physical, chemical and biological properties of electrospun scaffolds for wound dressings.

Biomed Mater 2019 Apr 8. Epub 2019 Apr 8.

Biología Celular y Tisular, Universidad Nacional Autonoma de Mexico Facultad de Medicina, Mexico, Coyoacán, MEXICO.

Chronic wounds are a global health problem, and their treatments are difficult and long lasting. The development of medical devices through tissue engineering has been conducted to heal this type of wound. In this study, it was demonstrated that the combination of natural and synthetic polymers, such as poly (D-L lactide-co-glycolide) (PLGA) and gelatin (Ge), were useful for constructing scaffolds for wound healing. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/ab1741
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http://dx.doi.org/10.1088/1748-605X/ab1741DOI Listing
April 2019
3 Reads

Development of bone screw using novel biodegradable composite orthopedic biomaterial: From material design to in-vitro biomechanical and in-vivo biocompatibility evaluation.

Biomed Mater 2019 Apr 5. Epub 2019 Apr 5.

School of Biosciences and Bioengineering, Indian Institute of Technology - Bombay, IIT-Bombay, Powai, Mumbai, 400076, INDIA.

A novel composite biomaterial for bone-soft tissue fixation applications was developed. MgO-Silk-PCL, Silk-PCL and MgO-PCL composites were prepared with variable filler concentrations (0, 10, 20 and 30% w/w of MgO nanoparticles and 0, 5, 10, 20 and 30% of degummed silk fiber) in PCL polymer. The highest mechanical properties were obtained with 10%MgO and 20%Silk (MSP) wih 1. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/ab16be
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http://dx.doi.org/10.1088/1748-605X/ab16beDOI Listing
April 2019
1 Read

Antimicrobial wound dressings with high mechanical conformability prepared through thiol-yne click photopolymerization reaction.

Biomed Mater 2019 Apr 5. Epub 2019 Apr 5.

Kharazmi University, Tehran, Tehran, Iran (the Islamic Republic of).

Radical mediated photochemical thiol-yne click polymerization of thiol-terminated polyurethane prepolymers, with poly(ethylene glycol) (PEG) soft segment at two different molecular weights, a propargyl terminated urethane crosslinker and silver salt was utilized to prepare versatile wound dressings containing well-dispersed Ag° nanoparticles produced via in situ reduction of Ag+ ions. The dressings with optimized chemical structure showed desirable fluid handling capacity (up to 4.84 g/10. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/ab16b8
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http://dx.doi.org/10.1088/1748-605X/ab16b8DOI Listing
April 2019
5 Reads

Hydroxyapatite nanowire composited gelatin cryogel with improved mechanical properties and cell migration for bone regeneration.

Biomed Mater 2019 Apr 2. Epub 2019 Apr 2.

Bejing University of Chemical Technology, Beijing, CHINA.

Hydrogels are normally not robust enough to meet the repairing requirements of bone defects, therefore, cryogels of higher mechanical properties are developed as the more proper candidates for the purpose. In view of the organic-inorganic composition of natural bone tissues, hydroxyapatite (HA) is envisioned as a good additive for protein cryogels to achieve biomimetic compositions, additionally, as an excellent reinforcement to increase the mechanical properties of cryogels. In this study, methacrylated gelatin (GelMA) was synthesized and corresponding 3D-structured cryogel was fabricated, followed by the incorporation of HA nanowires (HANWs) at different amounts as reinforcements. Read More

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http://dx.doi.org/10.1088/1748-605X/ab1583DOI Listing
April 2019
3.697 Impact Factor

An interview with Joyce Y Wong: ensuring all voices in biomaterials community are heard.

Authors:
Myron Spector

Biomed Mater 2019 03 27;14(3):030201. Epub 2019 Mar 27.

Harvard Medical School, Brigham and Women's Hospital, VA Boston Healthcare System, Boston, MA, United States of America.

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http://dx.doi.org/10.1088/1748-605X/ab08d3DOI Listing

Precise management of chronic wound by nisin with antibacterial selectivity.

Biomed Mater 2019 Mar 22. Epub 2019 Mar 22.

Technical Institute of Physics and Chemistry Chinese Academy of Sciences, Beijing, CHINA.

Traditional broad-spectrum antibacterial agents are limited by high toxicity and the destruction to the bacterial flora balance in the wound site. Herein, we propose an opinion that one or several especial antibacterial peptides are adopted to kill the target bacteria in order to precisely manage the bacteria infected chronic wound under the premise of biobalance, and specially employ nisin to treat S. aureus infected chronic wound as model with positive effects. Read More

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http://dx.doi.org/10.1088/1748-605X/ab12b3DOI Listing
March 2019
1 Read
3.697 Impact Factor

Poly (propylene fumarate) /β-calcium phosphate composites for enhanced bone repair.

Biomed Mater 2019 Mar 22. Epub 2019 Mar 22.

Key Laboratory for Ultrafine Materials of Ministry of Education;Engineering Research Center for Biomaterials of Ministry of Education;The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, Shanghai, CHINA.

A composite based on poly (propylene fumarate) (PPF) was investigated as a potential bone repair material for clinical use and it showed low heat release, suitable mechanical property and good biocompatibility. The in-situ curing process would finish in less than 10 minutes. Compared with PMMA, PPF/TCP showed great decrease in heat release as the maximum temperature during curing process was 54. Read More

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http://dx.doi.org/10.1088/1748-605X/ab12aeDOI Listing
March 2019
2 Reads

Organically modified hydroxyapatite (ormoHAP) nanospheres stimulate the differentiation of osteoblast and osteoclast precursors: a co-culture study.

Biomed Mater 2019 Apr 15;14(3):035015. Epub 2019 Apr 15.

Isolated nanospheres consisting of organically modified hydroxyapatite (ormoHAP), prepared by an electric field-assisted ion double migration process, were embedded in foamed gelatin to form a composite scaffold. Degradation rates have been demonstrated to correlate with the crosslinking degree (40%, 80%) as well as with the mineral content of the scaffolds (0%, 20%, 40%). A human co-culture model of osteoblasts and osteoclasts, derived from bone marrow stromal cells and monocytes, respectively, without external addition of the factors RANKL and M-CSF, was run for up to 42 d in order to characterize the action of the ormoHAP-gelatin scaffolds on the co-culture. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/ab0fad
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http://dx.doi.org/10.1088/1748-605X/ab0fadDOI Listing
April 2019
3 Reads

Biodegradable polymer promotes osteogenic differentiation in immortalized and primary osteoblast-like cells.

Biomed Mater 2019 Mar 11. Epub 2019 Mar 11.

Chemistry, Middle East Technical University, Chemistry Department,, Middle East Technical University,, Cankaya, Ankara, 06800, TURKEY.

Biodegradable polymers have been broadly used as agents that can complex with and deliver osteoinductive agents, but osteoinductivity of the polymers themselves has been rarely studied. Here we report the osteoinductivity of poly(4-hydroxy-L-proline ester) (PHPE), a biodegradable cationic polymer with cell penetrating properties. Under physiological conditions, PHPE degrades into trans-4-hydroxy-L-proline (trans-Hyp), a non-coded amino acid with essential functions in collagen fibril formation and fibril stability. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0e92DOI Listing
March 2019
3 Reads

Culture surfaces induce hypoxia-regulated genes in human mesenchymal stromal cells.

Biomed Mater 2019 Apr 5;14(3):035012. Epub 2019 Apr 5.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom. Department of Engineering Science, University of Oxford, Oxford, United Kingdom.

Culturing human Mesenchymal stromal cells (hMSCs) in vitro in hypoxic conditions resulted in reduced senescence, enhanced pluripotency and altered proliferation rate. It has been known that in vitro hypoxia affects expression of cell surface proteins. However, the impact of culture surfaces on the hypoxia-regulated genes (HRG) have not yet been reported. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0e61DOI Listing
April 2019
2 Reads

Properties of vaterite-containing tricalcium silicate composited graphene oxide for biomaterials.

Biomed Mater 2019 Mar 7. Epub 2019 Mar 7.

Nanjing Tech University, Nanjing, Jiangsu, CHINA.

The properties of vaterite-containing tricalcium silicate (referred as V-C3S) bone cement can be significantly affected by graphene oxide (GO) added. The composited bone cement can overcome the problem of poor mechanical properties and low cellular activity of calcium silicate-based bone cement. The material properties, mineralization and cell compatibility were characterized. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0de3DOI Listing

Electrospinning of highly porous yet mechanically functional microfibrillar scaffolds at the human scale for ligament and tendon tissue engineering.

Biomed Mater 2019 Apr 15;14(3):035016. Epub 2019 Apr 15.

Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.

Electrospun fibers offer tremendous potential for tendon and ligament tissue engineering, yet developing porous scaffolds mimicking the size, stiffness and strength of human tissues remains a challenge. Previous studies have rolled, braided, or stacked electrospun sheets to produce three-dimensional (3D) scaffolds with tailored sizes and mechanical properties. A common limitation with such approaches is the development of low porosity scaffolds that impede cellular infiltration into the body of the implant, thereby limiting their regenerative potential. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0de1DOI Listing

Exploring platelet lysate hydrogel-coated suture threads as biofunctional composite living fibers for cell delivery in tissue repair.

Biomed Mater 2019 Apr 5;14(3):034104. Epub 2019 Apr 5.

3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal. ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.

To engineer functional tissue substitutes, it is required a multi-component, multi-scale approach that combines both physical, chemical and biological cues. Fiber-based techniques have been explored in the field of tissue engineering to produce structures recapitulating tissue architecture and mechanical properties. In this work, we engineered biofunctional composite living fibers (CLF) as multi-compartment fibers with a mechanically competent core and a hydrogel layer. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0de6DOI Listing

Gliosis of astrocytes cultivated on coral skeleton is regulated by the matrix surface topography.

Biomed Mater 2019 Mar 6. Epub 2019 Mar 6.

Molecular Biology, Ariel University, Ariel, 40700, ISRAEL.

Astrogilosis is the response of astrocytes to brain trauma which manifest opposite roles on brain injury repair. On the one hand, astrocytes undergoing astrogliosis inhibit tissue regeneration by forming scar tissue, but, on the other hand, they enhance damage repair through secretion of neuro-protecting and neurotrophic factors. Therefore, identifying means that regulate astrogliosis can provide a control over progression and repair of brain damage. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0d69DOI Listing
March 2019
1 Read

Reversible 2D networks of oligo(ε-caprolactone) at the air-water interface.

Biomed Mater 2019 04 2;14(3):034103. Epub 2019 Apr 2.

Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße 55, D-14513 Teltow, Germany. Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Straße 24-25, D-14476 Potsdam, Germany.

Hydroxyl terminated oligo(ε-caprolactone) (OCL) monolayers were reversibly cross-linked forming two dimensional networks (2D) at the air-water interface. The equilibrium reaction with glyoxal as the cross-linker is pH-sensitive. Pronounced contraction in the area of the prepared 2D OCL films in dependence of surface pressure and time revealed the process of the reaction. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0cefDOI Listing
April 2019
1 Read

Aligned nanofibers of decellularized muscle ECM support myogenic activity in primary satellite cells in vitro.

Biomed Mater 2019 04 2;14(3):035010. Epub 2019 Apr 2.

Volumetric muscle loss (VML) is a loss of over ∼10% of muscle mass that results in functional impairment. Although skeletal muscle possesses the ability to repair and regenerate itself following minor injuries, VML injuries are irrecoverable. Currently, there are no successful clinical therapies for the treatment of VML. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0b06DOI Listing
April 2019
1 Read

In vitro evaluation of barium titanate nanoparticle/alginate 3D scaffold for osteogenic human stem cell differentiation.

Biomed Mater 2019 04 2;14(3):035011. Epub 2019 Apr 2.

Department of Biology, Federal University of Juiz de Fora, 36036-330, Juiz de Fora, Brazil.

Nanomaterials can mimic properties of extracellular matrix molecules, promising great potential for scaffold composition in tissue engineering. In the present study, we investigated whether barium titanate nanoparticles (BT NP) combined with alginate polymer would provide a new cytocompatible three-dimensional (3D) scaffold to induce osteogenic stem cell differentiation. In vitro cytocompatibility and osteogenic differentiation potential were investigated using human mesenchymal stem cells (MSC). Read More

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http://dx.doi.org/10.1088/1748-605X/ab0a52DOI Listing
April 2019
6 Reads

Porous, lithium-doped calcium polyphosphate composite scaffolds containing vascular endothelial growth factor (VEGF)-loaded gelatin microspheres for treating glucocorticoid-induced osteonecrosis of the femoral head.

Biomed Mater 2019 Apr 5;14(3):035013. Epub 2019 Apr 5.

Department of Orthopaedics, West China Hospital, Sichuan University, 37# Wainan Guoxue Road, Chengdu 610041, People's Republic of China.

Glucocorticoids-induced osteonecrosis of femoral head (GIONFH) is difficult to treat due to the pathophysiology remains uncertain. Core decompression and bone grafting are regarded as effective measures for treating early GIONFH. Furthermore, commonly used bone graft materials at nowadays are still unsatisfactory. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0a55DOI Listing

Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo.

Biomed Mater 2019 03 27;14(3):035007. Epub 2019 Mar 27.

Department of Surgery, The University of Melbourne, St Vincent's Hospital, Melbourne, VIC, Australia. ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, University of Wollongong, NSW, Australia. Biofab3D@ACMD, St Vincent's Hospital, Melbourne, VIC, Australia.

3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems and cell culture systems for tissue engineering. Critical to its success is the biocompatibility of the materials used, which should allow long-term tissue culture without affecting cell viability or inducing an inflammatory response for in vitro and in vivo applications. Polyjet 3D printers offer arguably the highest resolution with the fewest design constraints of any commercially available 3D printing systems. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/ab09c4
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http://dx.doi.org/10.1088/1748-605X/ab09c4DOI Listing
March 2019
2 Reads

A simplified fabrication technique for cellularized high-collagen dermal equivalents.

Biomed Mater 2019 Feb 22. Epub 2019 Feb 22.

Product Development Group Zurich, Eidgenossische Technische Hochschule Zurich Departement Maschinenbau und Verfahrenstechnik, Zurich, ZH, SWITZERLAND.

Human autologous bioengineered skin has been successfully developed and used to treat skin injuries in a growing number of cases. In current clinical studies, the biomaterial used is fabricated via plastic compression of collagen hydrogel to increase the density and stability of the tissue. To further facilitate clinical adoption of bioengineered skin, the fabrication technique needs to be improved in terms of standardization and automation. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/ab09c5
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http://dx.doi.org/10.1088/1748-605X/ab09c5DOI Listing
February 2019
3 Reads

Controllable fiber orientation and nonlinear elasticity of electrospun nanofibrous small diameter tubular scaffolds for vascular tissue engineering.

Biomed Mater 2019 03 21;14(3):035006. Epub 2019 Mar 21.

School of Mechanics Science and Engineering, National Center for International Research of Micro-nano Molding Technology, Zhengzhou University, Zhengzhou, People's Republic of China.

Biomimetic structures play an important role in controlling the cell behaviors of adhesion, proliferation, migration, and differentiation, which is beneficial for the regeneration of defective tissues. Scaffolds with a biomimetic structure are highly desirable in tissue engineering. In this study, we successfully fabricated three different types of tubular scaffold with randomly, circumferentially, and axially aligned structures, using synthetic bioabsorbable poly(L-lactide-co-caprolactone) via electrospinning. Read More

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http://dx.doi.org/10.1088/1748-605X/ab07f1DOI Listing
March 2019
2 Reads
3.697 Impact Factor

Native aortic valve derived extracellular matrix hydrogel for three dimensional culture analyses with improved biomimetic properties.

Biomed Mater 2019 Apr 5;14(3):035014. Epub 2019 Apr 5.

Department of Cardiovascular Surgery, Medical Faculty, Heinrich Heine University, Moorenstr. 5, D-40225, Duesseldorf, Germany.

Introduction: Calcific aortic valve disease (CAVD) is the most common acquired heart valve disease with complex underlying pathomechanisms that are yet not fully understood. Three-dimensional (3D) cell culture models as opposed to conventional two-dimensional (2D) techniques may reveal new aspects of CAVD and serve as a transitional platform between conventional 2D cell culture and in vivo experiments.

Methods: Here we report on fabrication and characterization of a novel 3D hydrogel derived from cell-free native aortic valves. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0791DOI Listing
April 2019
2 Reads

Use of cerium oxide nanoparticles: a good candidate to improve skin tissue engineering.

Biomed Mater 2019 03 27;14(3):035008. Epub 2019 Mar 27.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Today advancements in nanotechnology have made extensive progress in tissue engineering. Application of cerium oxide nanoparticles (CeO) has improved regenerative medicine due to their antioxidant properties. In this study, nanoparticles were used to increase the efficacy of skin substitutes. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0679DOI Listing
March 2019
6 Reads

Strontium ranelate simultaneously improves the radiopacity and osteogenesis of calcium phosphate cement.

Biomed Mater 2019 03 14;14(3):035005. Epub 2019 Mar 14.

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, People's Republic of China. Institute of Orthopedic Diseases and Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, People's Republic of China. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.

In a minimally invasive surgery of osteoporotic fractures, high radiopacity is necessary to monitor the delivery and positioning of injectable cements and good osteogenesis is indispensable. In this work, strontium ranelate (SrR), an agent for treating osteoporosis, is firstly used as a radiopaque agent for calcium phosphate cement (CPC). The addition of SrR does not affect the hydration products of CPC, but prolonged the setting time and decreased the compressive strength. Read More

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http://dx.doi.org/10.1088/1748-605X/ab052dDOI Listing
March 2019
3 Reads

Fabrication of hydrogel scaffolds via photocrosslinking of methacrylated silk fibroin.

Biomed Mater 2019 03 14;14(3):034102. Epub 2019 Mar 14.

JSC Efferon, Moscow, ter. Skolkovo Innovation Center, st. Nobel, 7, 121205, Russia. Department of Biology, Lomonosov Moscow State University, Leninskie Gory, 1-12, 119991, Moscow, Russia.

Silk fibroin is a promising biomaterial for tissue engineering due to its valuable mechanical and biological properties. However, being a natural product and a protein, it lacks the processability and uniform quality of an advanced synthetic material. Here we propose a way to overcome this contradiction using novel fibroin photocrosslinkable derivative (FBMA). Read More

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http://dx.doi.org/10.1088/1748-605X/ab04e0DOI Listing
March 2019
1 Read

Biocompatible polyvinyl alcohol and RISUG blend polymeric films with spermicidal potential.

Biomed Mater 2019 Apr 15;14(3):035017. Epub 2019 Apr 15.

School of Medical Science and Technology, Indian Institute of Technology, Kharagpur 721302, India. School of Bio-Science and Engineering, Jadavpur University, Kolkata, West Bengal 700098, India.

Majority of the commercially available vaginal contraceptives encompasses cervicovaginal membrane disrupting detergent molecules as pharmacologically active ingredients. Development of a tissue-compatible vaginal contraceptive agent is necessary to circumvent the existing demand for female contraception in the reproductive healthcare sector. With this objective, the present study delineates the use of RISUG based non-hormonal female contraceptive films. Read More

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http://dx.doi.org/10.1088/1748-605X/ab04e1DOI Listing
April 2019
9 Reads

MSC differentiation on two-photon polymerized, stiffness and BMP2 modified biological copolymers.

Biomed Mater 2019 03 7;14(3):035001. Epub 2019 Mar 7.

Department of Oral and Maxillofacial Surgery, University Medicine Göttingen, Germany.

Introduction: Bone tissue regeneration requires a three-dimensional biological setting. An ideal scaffold should enable cell proliferation and differentiation by mimicking structure and mechanical properties of the compromised defect as well as carrying growth factors. Two-photon polymerization (2PP) allows the preparation of 3D structures with a micrometric resolution. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0362DOI Listing
March 2019
1 Read

Pre-culture of adipose-derived stem cells and heterologous acellular dermal matrix: paracrine functions promote post-implantation neovascularization and attenuate inflammatory response.

Biomed Mater 2019 Jan 30. Epub 2019 Jan 30.

Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, CHINA.

Heterologous acellular dermal matrix (ADM) has good biocompatibility and sufficient strength for clinical use for the repair of defects, tissue filling, and resurfacing of deep wounds. However, ADM tissue has such a compact structure that it can easily result in delayed vascularization after implantation. Moreover, in spite of the low immunogenicity of heterologous ADM, it can still cause varying degrees of inflammation in the host. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0355DOI Listing
January 2019

Editorial: Biofunctional biomaterials and cellular systems for diagnostic and therapeutic purposes.

Biomed Mater 2019 01 30;14(2):020201. Epub 2019 Jan 30.

Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland. Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.

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http://dx.doi.org/10.1088/1748-605X/aafd84DOI Listing
January 2019

Fabrication of biocomposite scaffolds made with modified hydroxyapatite inclusion of chitosan-grafted-poly(methyl methacrylate) for bone tissue engineering.

Biomed Mater 2019 02 25;14(2):025013. Epub 2019 Feb 25.

Department of Physics, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.

In the present study, composite scaffolds of chitosan-graft-poly(methyl methacrylate) (Chi-g-PMMA) and mineral ions-loaded hydroxyapatite (mHA) (obtained by the hydrothermal treatment of hydroxyapatite (HA) in a simulated body fluid (SBF) solution (mHA@Chi-g-PMMA)) were prepared by the blending method. The physical properties, bioactivity, biological properties and their capabilities for sustained drug and protein release were studied. Physicochemical analysis showed a successful incorporation of the mineral ions in the HA particles and a good distribution of the mHA within the Chi-g-PMMA polymer matrix. Read More

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http://dx.doi.org/10.1088/1748-605X/ab025fDOI Listing
February 2019

Synthesis and characterization of rGO-graft-poly(trimethylene carbonate) for nerve regeneration conduits.

Biomed Mater 2019 03 7;14(3):034101. Epub 2019 Mar 7.

Dept. of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands.

Graphene-graft-polymer has been used to improve the compatibility between graphene and a polymer matrix, and to further enhance electrical, mechanical and biological properties of polymer/graphene composites. In this study, poly(trimethylene carbonate) (PTMC) was successfully grafted onto graphene surface via 'grafting from' method. Reduced graphene oxide (rGO) initiator was synthesized by azido ethanol reaction with graphene oxide (GO) at high temperature. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0269DOI Listing
March 2019
3 Reads

Nanocrystalline cellulose-hyaluronic acid composite enriched with GM-CSF loaded chitosan nanoparticles for enhanced wound healing.

Biomed Mater 2019 03 7;14(3):035003. Epub 2019 Mar 7.

Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

In recent years, applications of biopolymers such as hyaluronic acid (HA) for wound dressing have attracted more attention. However, the poor mechanical properties of HA-based wound dressings limit their clinical applications. Incorporation of reinforcing agents such as nanocrystalline cellulose (CNC) in HA-based wound dressings can improve their mechanical properties. Read More

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http://dx.doi.org/10.1088/1748-605X/ab026cDOI Listing
March 2019
2 Reads

Preparation of ADM/PRP freeze-dried dressing and effect of mice full-thickness skin defect model.

Biomed Mater 2019 03 7;14(3):035004. Epub 2019 Mar 7.

The Graduate School of Southern Medical University, Guangzhou 510515, People's Republic of China. Center of Wound Treatment, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, People's Republic of China.

Acellular dermal matrix (ADM) and platelet-rich plasma (PRP) have each been used in wound healing. There are a few reports on the application of ADM with PRP in skin full-thickness defect models. In this study, the microstructure of ADM/PRP freeze-dried dressing was observed by scanning electron microscope. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0060DOI Listing
March 2019
1 Read

Resorbable PCEC/gelatin-bismuth doped bioglass-graphene oxide bilayer membranes for guided bone regeneration.

Biomed Mater 2019 Apr 15;14(3):035018. Epub 2019 Apr 15.

Department of Engineering Sciences, Middle East Technical University, Ankara, Turkey.

Guided bone regeneration (GBR) is a therapeutic modality applied prior to dental implant placement to increase bone density at the defect site or during placement for directing bone growth around implant. In this study, an asymmetric, bilayer structure was prepared by covalently bonding a dense polycaprolactone-polyethylene glycol-polycaprolactone (PCEC) membrane layer with a hydrogel layer composed of bismuth doped bioactive glass (BG, 45S5) and graphene oxide (GO) particles incorporated in gelatin. Structural and mechanical properties (surface morphology and chemistry, thickness, degradation rate and tensile strength of GBR membranes) were studied. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/ab007b
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http://dx.doi.org/10.1088/1748-605X/ab007bDOI Listing
April 2019
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A novel polyurethane-based biodegradable elastomer as a promising material for skeletal muscle tissue engineering.

Biomed Mater 2019 02 25;14(2):025014. Epub 2019 Feb 25.

Ankara University Faculty of Engineering, Department of Biomedical Engineering, Ankara, Turkey. Ankara University Biotechnology Institute, Ankara, Turkey.

A key challenge in skeletal muscle tissue engineering is the choice of a proper scaffolding material as it should demonstrate elastic behavior to withstand and support the dynamic loading of the tissue microenvironment while being biodegradable and biocompatible. In this study, we tested the applicability of a novel biodegradable polyurethane (PU) elastomer chain extended with fibrinogen (Fib) to fulfill these requirements. Biodegradable polyurethane-fibrinogen (PU-Fib) elastomers were synthesized by step-wise condensation polymerization. Read More

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http://dx.doi.org/10.1088/1748-605X/ab007aDOI Listing
February 2019
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Fabrication of poly (trimethylene carbonate)/reduced graphene oxide-graft-poly (trimethylene carbonate) composite scaffolds for nerve regeneration.

Biomed Mater 2019 02 25;14(2):024104. Epub 2019 Feb 25.

Department of Biomaterials Science and Technology, University of Twente, The Netherlands.

One of the key challenges for neural tissue engineering is to exploit functional materials to guide and support nerve regeneration. Currently, reduced graphene oxide (rGO), which is well-known for its unique electrical and mechanical properties, has been incorporated into biocompatible polymers to manufacture functional scaffolds for nerve tissue engineering. However, rGO has poor dispersity in polymer matrix, which limits its further application. Read More

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http://dx.doi.org/10.1088/1748-605X/ab0053DOI Listing
February 2019
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A Pyk2 inhibitor incorporated into a PEGDA-gelatin hydrogel promotes osteoblast activity and mineral deposition.

Biomed Mater 2019 02 27;14(2):025015. Epub 2019 Feb 27.

Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN 46202, United States of America.

Pyk2 is a non-receptor tyrosine kinase that belongs to the family of focal adhesion kinases. Studies from our laboratory and others demonstrated that mice lacking the Pyk2 gene (Ptk2B) have high bone mass, which was due to increased osteoblast activity, as well as decreased osteoclast activity. It was previously reported that a chemical inhibitor that targets both Pyk2 and its homolog FAK, led to increased bone formation in ovariectomized rats. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/aafffa
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http://dx.doi.org/10.1088/1748-605X/aafffaDOI Listing
February 2019
8 Reads

Injectable and biocompatible chitosan-alginic acid hydrogels.

Biomed Mater 2019 02 8;14(2):025010. Epub 2019 Feb 8.

Department of Materials Science, Ningbo University of Technology, 201 Fenghua Road, Ningbo, Zhejiang, 315211, People's Republic of China.

Injectable and biocompatible polysaccharide hydrogels are ideal scaffolds for drug delivery and tissue engineering. Here, we report a new in situ forming hydrogels by self-crosslinking chitosan and a biocompatible polymeric crosslinker, oxidized alginic acid. The dialdehyde alginic acid was synthesized by the oxidant reaction of alginic acid with sodium periodate. Read More

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http://dx.doi.org/10.1088/1748-605X/aaff3dDOI Listing
February 2019
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Bicyclic RGD peptides with high integrin α β and α β affinity promote cell adhesion on elastin-like recombinamers.

Biomed Mater 2019 03 27;14(3):035009. Epub 2019 Mar 27.

Technical Proteins Nanobiotechnology S.L., Paseo Belén 9A, E-47001 Valladolid, Spain.

Biomaterial design in tissue engineering aims to identify appropriate cellular microenvironments in which cells can grow and guide new tissue formation. Despite the large diversity of synthetic polymers available for regenerative medicine, most of them fail to fully match the functional properties of their native counterparts. In contrast, the few biological alternatives employed as biomaterials lack the versatility that chemical synthesis can offer. Read More

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http://dx.doi.org/10.1088/1748-605X/aafd83DOI Listing

Enzyme-oxidative-polymerization method for improving glycosaminoglycans stability and reducing calcification in bioprosthetic heart valves.

Biomed Mater 2019 02 8;14(2):025012. Epub 2019 Feb 8.

Glutaraldehyde (GLUT) crosslinked bioprosthetic heart valves (BHVs) might fail within ten years due to progressive degradation and calcification. GLUT cannot stabilize glycosaminoglycans (GAGs), one important component of BHVs. In this current study we developed a new BHVs preparation strategy named as 'HPA/NT/HRP' treatment that utilized 3,4-hydroxyphenylpropionic acid (HPA)/tyramine (TRA)/neomycin trisulfate (NT) conjugated pericardiums and horseradish peroxidase (HRP)/HO enzyme-oxidative-polymerization method. Read More

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http://dx.doi.org/10.1088/1748-605X/aafd7cDOI Listing
February 2019
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Skin wound regeneration with bioactive glass-gold nanoparticles ointment.

Biomed Mater 2019 02 8;14(2):025011. Epub 2019 Feb 8.

Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania. Faculty of Physics, Babeș-Bolyai University, 400084 Cluj-Napoca, Romania.

The bioactive glasses can lead to the promotion of growth of granulation tissue, while the gold nanoparticles (AuNPs) can induce the acceleration of wound healing including tissue regeneration, connective tissue formation, and angiogenesis. The aim of this study was to evaluate the impact of using the bioactive glass (BG) and BG-AuNPs composites on skin wound healing in experimental rat models for 14 days. Sol-gel derived BGs and BG-AuNPs composites mixed with Vaseline at 6, 12 and 18 wt% were used to evaluate the repair response of the skin. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/aafd7d
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http://dx.doi.org/10.1088/1748-605X/aafd7dDOI Listing
February 2019
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A novel hybrid silk-fibroin/polyurethane three-layered vascular graft: towards in situ tissue-engineered vascular accesses for haemodialysis.

Biomed Mater 2019 01 30;14(2):025007. Epub 2019 Jan 30.

Bioengineering Laboratories S.r.l., Cantù, Italy. Dipartimento di Elettronica Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.

Clinically available alternatives of vascular access for long-term haemodialysis-currently limited to native arteriovenous fistulae and synthetic grafts-suffer from several drawbacks and are associated to high failure rates. Bioprosthetic grafts and tissue-engineered blood vessels are costly alternatives without clearly demonstrated increased performance. In situ tissue engineering could be the ideal approach to provide a vascular access that profits from the advantages of vascular grafts in the short-term (e. Read More

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http://dx.doi.org/10.1088/1748-605X/aafc96DOI Listing
January 2019

Hybrid core-shell scaffolds for bone tissue engineering.

Biomed Mater 2019 01 30;14(2):025008. Epub 2019 Jan 30.

Biomedical Engineering Division, School of Engineering, University of Glasgow, University Avenue, Glasgow, G12 8QQ, United Kingdom.

The tissue engineering applications of coaxial electrospinning are growing due to the potential increased functionality of the fibres compared to basic electrospinning. Previous studies of core and shell scaffolds have placed the active elements in the core, however, the surface response to a biomaterial affects the subsequent behaviour, thus here hydroxyapatite (HA) was added to the shell. Coaxial electrospun polycaprolactone (PCL)-polylactic acid (PLA)/HA (core-shell) scaffolds were produced in 2D sheets using a plate collector, or 3D tubes for bone tissue engineering using a rotating needle collector. Read More

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http://dx.doi.org/10.1088/1748-605X/aafbf1DOI Listing
January 2019

Cell and tissue responses at the interface with a chitosan hydrogel intended for vascular applications: in vitro and in vivo exploration.

Biomed Mater 2019 01 30;14(2):025009. Epub 2019 Jan 30.

Univ. Bordeaux, BIOTIS, F-33000 Bordeaux, France. CHU Bordeaux, Pôle Odontologie et Santé Buccale, F-33000 Bordeaux, France.

Aims: The need for small caliber vessels to treat cardiovascular diseases has grown. However, synthetic polymers perform poorly in small-diameter applications. Chitosan hydrogels can provide a novel biological scaffold for vascular engineering. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/aafbf0
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http://dx.doi.org/10.1088/1748-605X/aafbf0DOI Listing
January 2019
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Development macro-porous electro-spun meshes with clinically relevant mechanical properties-a technical note.

Biomed Mater 2019 01 10;14(2):024103. Epub 2019 Jan 10.

Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), National University of Ireland Galway (NUI Galway), Galway, Ireland. Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway (NUI Galway), Galway, Ireland.

The nano-fibrous architecture of electro-spun meshes favours their use in biomedicine, but their low mechanical properties prohibit their wide use in clinical practice. Introduction of porosity, essential of tissue integration, decreases further mechanical integrity. Herein, we hypothesised that macro-porous electro-spun meshes with adequate mechanical properties can be fabricated through layering and subsequent compression. Read More

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http://iopscience.iop.org/article/10.1088/1748-605X/aaf929
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http://dx.doi.org/10.1088/1748-605X/aaf929DOI Listing
January 2019
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Controllable fabrication of hydroxybutyl chitosan/oxidized chondroitin sulfate hydrogels by 3D bioprinting technique for cartilage tissue engineering.

Biomed Mater 2019 01 10;14(2):025006. Epub 2019 Jan 10.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, United States of America.

Biological regeneration of articular cartilage continues to be a challenge at present. Functional engineered implants with patient-specific sizes are difficult to achieve. The aim of this study is to fabricate a biocompatible cell-laden hydrogel with a designable structure. Read More

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http://dx.doi.org/10.1088/1748-605X/aaf8edDOI Listing
January 2019
3 Reads
3.697 Impact Factor

Marble-derived microcalcite improves bone healing in mice osteotomy.

Biomed Mater 2018 12 7;14(2):025001. Epub 2018 Dec 7.

Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Homburg, Germany. Institute for Clinical and Experimental Surgery, Saarland University, Homburg, Germany.

Approximately 10% of all fractures result in delayed healing or non-unions. Bone healing can be improved by the application of osteoconductive and osteoinductive biomaterials. Microcalcite (MCA) as a naturally available calcium carbonate-based biomaterial derived from marble may have the potential to improve bone healing. Read More

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http://dx.doi.org/10.1088/1748-605X/aaee54DOI Listing
December 2018
3 Reads

Enhanced mechanical and cell adhesive properties of photo-crosslinked PEG hydrogels by incorporation of gelatin in the networks.

Biomed Mater 2019 01 4;14(2):024102. Epub 2019 Jan 4.

Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands.

Although synthetic polymers may have suitable physicochemical properties for biomedical applications, biological properties are generally lacking. Poly(ethylene glycol) (PEG) is a frequently used polymer for the preparation of hydrogels. Due to its hydrophilic character, however, cellular interactions with PEG hydrogels are minimal or absent. Read More

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http://dx.doi.org/10.1088/1748-605X/aaf31bDOI Listing
January 2019