1,004 results match your criteria Biomedical Journal[Journal]


Podoplanin promotes cancer-associated thrombosis and contributes to the unfavorable overall survival in an ectopic xenograft mouse model of oral cancer.

Biomed J 2019 Dec 24. Epub 2019 Dec 24.

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Graduate Institute of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Podoplanin (PDPN) is a transmembrane glycoprotein that mediates tumor cell-induced platelets aggregation in different cancer types. Emerging data indicate that PDPN is a marker for poor prognosis of human oral squamous cell carcinoma (OSCC). However, the functional impacts of PDPN on cancer formation and disease progression of OSCC remain to be elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.07.001DOI Listing
December 2019

Deregulation of Stemness-Related Genes in Endometriotic Mesenchymal Stem Cells: Further Evidence for Self-Renewal/Differentiation Imbalance.

Iran Biomed J 2020 Apr 18. Epub 2020 Apr 18.

Endometriosis Research Center, Iran University of Medical Science, Tehran, Iran.

Background: Any irregularities in self-renewal/differentiation balance in endometriotic MSCs can change their fate and function, resulting in endometriosis development. This study aimed to evaluate the expression of OCT4 transcripts (OCT4A, OCT4B, and OCT4B1), SOX2, and NANOG in endometriotic MSCs to show their aberrant expression and to support self-renewal/differentiation imbalance in these cells.

Methods: MSCs were isolated from three endometriotic and three normal endometrium samples and characterized and analyzed for the expressions of OCT4A, OCT4B, OCT4B1, SOX2, and NANOG using the qRT-PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.328DOI Listing

In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis.

Iran Biomed J 2020 Feb 19. Epub 2020 Feb 19.

Department of Medical Mycology, Pasteur Institute of Iran, Tehran 1316943551, Iran.

Background: The Candida albicans is one of the most important global opportunistic pathogens, and the incidence of candidiasis has increased over the past few decades. Despite the established role of skin in defense against fungal invasion, little has been documented about the pathogenesis of Candida species when changing from normal flora to pathogens of vaginal and gastrointestinal epithelia. This study was carried out to determine in vivo and in vitro pathogenesis of clinical C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.319DOI Listing
February 2020

Aerial Parts of Peucedanum chenur Have Anti-Cancer Properties through the Induction of Apoptosis and Inhibition of Invasion in Human Colorectal Cancer Cells.

Iran Biomed J 2020 Mar 4. Epub 2020 Mar 4.

Research Center for Molecular Medicine and Genetics, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: The Peucedanum species have many pharmacological effects due to the presence of coumarins, flavonoids, phenolic compounds, and essential fatty acids in these species. In this study, for the first time, the anticancer activity of Peucedanum chenur methanolic extract via the induction of apoptosis and inhibition of invasion in HCT-116 human colon cancer cells was investigated.

Methods: P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.309DOI Listing

Effect of Paroxetine on the Neuropathic Pain: A Molecular Study.

Iran Biomed J 2020 May 2. Epub 2020 May 2.

Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Neuropathic pain due to damage to the peripheral nerve has influenced millions of people living all over the world. It has been shown that paroxetine can relieve neuropathic pain. Recently, the role of some proteins like BDNF, GABAA receptor, and KCC2 transporter in the occurrence of neuropathic pain has been documented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.301DOI Listing

Evaluation of 1,25(OH)2D3 Effects on FOXP3, ROR-γt, GITR, and CTLA-4 Gene Expression in the PBMCs of Vitamin D-Deficient Women with Unexplained Recurrent Pregnancy Loss (URPL).

Iran Biomed J 2020 Feb 23. Epub 2020 Feb 23.

Research Center for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran.

Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on fetus and pregnancy outcomes. This study aimed at evaluating the effect of 1,25VitD3 on specific transcription factor and markers of Tregs and Th17 cells in the PBMCs of women with URPL as a case group and the PBMCs of healthy women as a control group.

Methods: Samples from 20 non-pregnant patients with a history of URPL were compared to 20 normal non-pregnant women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.290DOI Listing
February 2020

Association of HDAC8 Expression with Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis.

Iran Biomed J 2020 May 2. Epub 2020 May 2.

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: Previous data have shown the tumorigenicity roles of HDAC8 in breast cancer. More recently, the oncogenic effects of this molecule have been revealed in TNBC. The present study aimed to determine the diagnostic value of HDAC8 for the differentiation of TNBC from nTNBC tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.283DOI Listing

Effects of Yacon on Colonic IFN-γ and Goblet Cells of 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Mouse Model.

Iran Biomed J 2020 Jan 20. Epub 2020 Jan 20.

Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Indonesia.

Background: IBD is a chronic inflammatory condition associated with damage to the intestinal mucosal barrier. Supplementation of yacon tubers has been known to give positive effect in intestinal health. Therefore, we conducted the study to investigate the effect of yacon tuber powder on Th1 activation pathway by evaluating IFN-γ levels and the number of goblet cells in the colon of colitis mouse models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.276DOI Listing
January 2020

The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy.

Iran Biomed J 2020 04 29. Epub 2020 Apr 29.

Department of Cell and Molecular Biology, School of Biology, College of Sciences, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.

Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseases, including many human cancers, neurodegenerative, skin, bone and heart deficiencies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.5.264DOI Listing

Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor.

Biomed J 2020 May 18. Epub 2020 May 18.

Department of Pharmaceutical Chemistry, Matoshri Institute of Pharmacy, Yeola, Nashik, Maharashtra, 423401, India.

Objective: The present study demonstrates the potential of flavanoid narcissoside against the novel corona virus (COVID-19) complications using molecular docking studies.

Method: The computation molecular docking screening was performed using Molegro Virtual Docker software (MVD) with grid resolution of 30 Å. Protein of COVID 19 virus was taken from protein data bank. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233213PMC

Artificial intelligence approach fighting COVID-19 with repurposing drugs.

Biomed J 2020 May 15. Epub 2020 May 15.

Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.

Background: The ongoing COVID-19 pandemic has caused more than 193,825 deaths during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic medicine that has prior use experiences in patients in order to resolve the current pandemic situation before it could become worsening. Artificial intelligence (AI) technology is hereby applied to identify the marketed drugs with potential for treating COVID-19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227517PMC

MicroRNA-95-3p inhibits cell proliferation and metastasis in colorectal carcinoma by HDGF.

Biomed J 2020 May 14. Epub 2020 May 14.

Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background: MicroRNAs (miRNAs) play an important regulatory role in carcinogenesis and cancer progression. MiR-95-3p has been reported to be an oncogene in hepatocellular carcinoma. However, the role of miR-95-3p in colorectal carcinoma (CRC) remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.03.006DOI Listing

A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide).

Biomed J 2020 May 7. Epub 2020 May 7.

Polymers and Pigments Department, National Research Center, 33 El Bohouth St, Dokki, 12311 Cairo, Egypt. Electronic address:

Background: The aim of the present study was to fabricate double layered scaffolds of electrospun polycaprolactone (PCL) and poly(ethylene oxide) (PEO). The electrospun PCL fibers were functionalized with wintergreen oil (WO) as a novel approach to prevent vascular grafts failure due to thrombosis by adjusting biomaterial-blood interactions.

Methods: PCL tubular scaffolds were prepared by electrospinning approach and coated with PEO as a hydrophilic polymer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.008DOI Listing

Outcome and Cost Analysis of Primary Total Knee Arthroplasty in End-stage Renal Disease Patients: A Nationwide Population-based Study.

Biomed J 2020 May 7. Epub 2020 May 7.

Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Linkou, No.5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan (R.O.C.); Bone and Joint Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan, No.5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan (R.O.C.). Electronic address:

Background: A number of patients with end-stage renal disease (ESRD) undergo total knee arthroplasty (TKA) due to advanced knee joint osteoarthritis. There are few studies describing the incidence, morbidities, mortality rate, and cost analysis regarding ESRD patients receiving TKA.

Material And Methods: We retrospectively retrieved patient data from National Health Insurance Research Database in Taiwan during 2005 to 2011, and evaluated the outcomes of TKA in patients with (ESRD group) and without ESRD (non-ESRD group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.010DOI Listing

Therapeutic effect of bone marrow mesenchymal stem cells in a rat model of carbon tetrachloride induced liver fibrosis.

Biomed J 2020 May 7. Epub 2020 May 7.

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Background: Liver fibrosis is a major medical problem with high mortality and morbidity rates where the formation of regenerative nodules and cirrhosis leads to loss of liver function and may result in the development of hepatocellular carcinoma. Bone marrow Mesenchymal stem cells (BM-MSCs) have drawn attention as a novel approach for treatment of liver fibrosis. This study aimed to evaluate the therapeutic effect of BM-MSCs on the liver structure in carbon tetrachloride (CCl) induced liver fibrosis in male rats relative to resveratrol and Silybum marianum as standard drugs derived from herbal plants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.011DOI Listing

Clinical characteristics and treatment outcome of adenoid cystic carcinoma in the external auditory canal.

Biomed J 2020 May 7. Epub 2020 May 7.

Department of Otolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: This study reviewed the clinical manifestations, pathological findings, and treatment outcomes of adenoid cystic carcinoma (ACC) in the external auditory canal (EAC).

Methods: This was a retrospective review of 12 patients with a diagnosis of ACC in the EAC seen in a single institution over a 30-year period. Data on the demographics, clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.07.005DOI Listing

COVID-19: The first documented coronavirus pandemic in history.

Biomed J 2020 May 5. Epub 2020 May 5.

The Research Center for Emerging Viral Infection, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan; Clinical Virology Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Electronic address:

The novel human coronavirus disease COVID-19 has become the fifth documented pandemic since the 1918 flu pandemic. COVID-19 was first reported in Wuhan, China, and subsequently spread worldwide. The coronavirus was officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses based on phylogenetic analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199674PMC

Interventions of aqueous extract of Solanum melongena fruits (garden eggs) on mercury chloride induced testicular toxicity in adult male Wistar rats.

Biomed J 2020 May 6. Epub 2020 May 6.

Department of Anatomy, College of Medicine, University of Abuja, Federal Capital Territory (FCT), Nigeria.

Background: Solanum melongena (SM) is commonly known as the garden egg fruit or eggplant. It can be eaten fresh or cooked and has a large history of consumption in West Africa. This study focused on interventions of aqueous extract of SM (garden eggs) fruits on Mercury chloride (HgCl) induced testicular toxicity in adult male Wistar rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.07.004DOI Listing

Is maternal serum inhibin A a good predictor in preterm labor? - Experience from a community hospital in Taiwan.

Biomed J 2020 May 6. Epub 2020 May 6.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: We aimed to determine whether inhibin A could be a reliable and accurate predictor of preterm birth, and discuss the possible pathogenic processes of inhibin A leading to preterm birth.

Methods: A retrospective cohort study was conducted on consecutive singleton pregnant women who underwent the second-trimester quad screen test at a gestational age of 15-20 weeks at Keelung Chang-Gung Memorial Hospital from March 2011 to May 2015. Data including maternal characteristics and pregnancy outcomes were collected from an electric medical record database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.08.001DOI Listing

Brain-derived neurotrophic factor and mental disorders.

Biomed J 2020 May 5. Epub 2020 May 5.

Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Genomic and Proteomic Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Kaohsiung, Taiwan. Electronic address:

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.01.001DOI Listing

Balancing the dental occlusion and facial aesthetic features in cleft orthognathic surgery: Patient-centered concept for computer-aided planning.

Biomed J 2020 May 4. Epub 2020 May 4.

Department of Plastic and Reconstructive Surgery and Craniofacial Research Center, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Patients with cleft lip and palate could develop dentofacial deformity characterized by malocclusion, midface retrusion, midline discrepancy and asymmetry. Cleft orthognathic surgery has evolved from the simple maxillary LeFort I advancement with correction of dental malocclusion to the current model of patient-centered approach focusing on skeletofacial reconstruction using computer-assisted diagnosis and planning. Three-dimensional imaging and surgical simulation have provided valuable information for facial aesthetics and surgical feasibility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.12.008DOI Listing

Primary ovarian insufficiency, meiosis and DNA repair.

Authors:
Reiner A Veitia

Biomed J 2020 May 4. Epub 2020 May 4.

Paris-Saclay University, Institute for Biology François Jacob, Atomic Energy Commissariat, Fontenay aux Roses, France; University of Paris, National Center for Scienftic Research (CNRS), Jacques Monod Institute, Paris, France. Electronic address:

Premature ovarian insufficiency (POI) is a major cause of female infertility. It is a heterogeneous disease that affects about 1% of women under 40 years of age. POI may be due to abnormal follicle stock formation, increased follicular atresia, impaired recruitment of dominant follicles, blocked follicular maturation or rapid depletion of the follicular stock. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.03.005DOI Listing

Banking on teeth - Stem cells and the dental office.

Biomed J 2020 May 4. Epub 2020 May 4.

University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, CA, USA. Electronic address:

Science and commerce advance together and the stem cell field is no exception. With the promise of cures for conditions as diverse as cancer, autism, neural degeneration, organ replacement and addiction, long-term preservation of dental stem cells is a growth market. The discovery nearly twenty years ago, of viable, multipotent, stem cells in dental pulp from both baby and adult teeth initiated, and drives, this market. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.02.003DOI Listing

Intravascular Large B-cell lymphoma: A case series and review of literatures.

Biomed J 2020 Apr 25. Epub 2020 Apr 25.

Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taiwan; School of Medicine, Chang Gung University, Taiwan. Electronic address:

Objectives: Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of non-Hodgkin lymphoma with uncommon clinical presentations and poor prognosis. The purpose of this study is to report the clinical features and outcome of IVLBCL in a single institution of Taiwan.

Patient And Methods: Ten patients with IVLBCL diagnosed from June 2006 to January 2018 were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.005DOI Listing

Point-of-care ultrasound of optic nerve sheath diameter to detect intracranial pressure in neurocritically ill children - A narrative review.

Biomed J 2020 Apr 23. Epub 2020 Apr 23.

Division of Pediatric Neurology, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address:

The rapid diagnosis of increased intracranial pressure is urgently needed for therapeutic reasons in neurocritically ill children, however this can rarely be achieved without invasive procedures. Point-of-care ultrasound of the optic nerve sheath diameter has been proposed as a non-invasive and reliable means to detect increased intracranial pressure in adults. Accordingly, clinicians may be able to use this technique to initiate early treatment and monitor the effectiveness of treatment in conjunction with other clinical examination and diagnostic modalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.006DOI Listing

Bargain with the tooth fairy - The savings accounts for dental stem cells.

Biomed J 2020 Apr 22. Epub 2020 Apr 22.

University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Copenhagen, Denmark. Electronic address:

Despite the hard times COVID-19 has imposed on us, the Biomedical Journal strives to provide fresh and compelling reading material - to be enjoyed safely from home. In this issue, we glance behind the scenes of dental stem cell preservation for potential therapeutic use, and discover that cancer cells hijack podoplanin expression to induce thrombosis. Moreover, we learn how the helicase DDX17 promotes tumour stemness, how genetic defects in meiosis and DNA repair cause premature ovarian insufficiency, and that the brain-derived neurotrophic factor is associated with several psychiatric diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195095PMC

Neurocritical care of premature infants.

Authors:
Reyin Lien

Biomed J 2020 Apr 22. Epub 2020 Apr 22.

Division of Neonatology, Department of Pediatrics, Chang Gung Medical Center, Lin Kou, School of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Neurocritical care is an approach of comprehensive care through multidisciplinary coordination and implementation of neuroprotective strategies to reduce the risk of neurologic injury among critically ill patients. Premature infants are at a special risk of sustaining brain injury and having adverse neurodevelopmental outcome. The pathogenesis of "encephalopathy of prematurity" is tightly linked to hemodynamic instability during postnatal transition, immaturity of the cerebral vascular bed and nervous system, and the commonly encountered inflammation in an intensive care setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.03.007DOI Listing

Neurocritical care and target immunotherapy for febrile infection-related epilepsy syndrome.

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Department of Pediatric Neurology, Children's Medical Center, Osaka City General Hospital, Osaka, Japan.

Febrile infection-related epilepsy syndrome (FIRES) is an intractable neurological disease characterized by an unexplained refractory status epilepticus triggered by febrile infection. A Consensus definition of FIRES was proposed in 2018, and its clinical features and prognosis are gradually being clarified. However, the development of effective treatments has been hindered as the etiology of this rare disease is as yet unelucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.03.009DOI Listing

Endoscopic transcanal removal of external auditory canal osteomas.

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Department of Otolaryngology-Head and Neck Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Department of Audiology and Speech Language Pathology, Mackay Medical College, Taiwan. Electronic address:

Background: External auditory canal (EAC) osteomas are rare, slow-growing benign neoplasms. Microscopic surgical excision had been reported for symptomatic osteomas. However, there was no study published on the feasibility of transcanal endoscopic ear surgery (TEES) for EAC osteoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.003DOI Listing

Typical and atypical enteropathogenic Escherichia coli in children with acute diarrhoea: Changing trend in East Delhi.

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Department of Microbiology, University College of Medical Sciences (University of Delhi), Guru Teg Bahadur Hospital, Delhi, 110095, India. Electronic address:

Background: Worldwide around 2 million deaths occur every year due to diarrhoeal illnesses among children less than 5 years of age. Among diarrhoeagenic Escherichia coli, Enteropathogenic E. coli (EPEC) is highly prevalent in both community and hospital settings and is one of the main causes of persistent diarrhea in children in developing countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.03.011DOI Listing

Neurotrophins BDNF and NT4/5 accelerate dental pulp stem cell migration.

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Department of Biomedical Sciences, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA, 94103, USA.

Neurotrophic factors play important roles in neuron survival, growth and differentiation. In the present research, the expression of multiple neurotrophins and their effects on cell migration were studied in the dental pulp stem cells (DPSCs). Human DPSCs from five patients were cultured. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.03.010DOI Listing

Therapeutic hypothermia for pediatric refractory status epilepticus May Ameliorate post-status epilepticus epilepsy.

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Division of Pediatric Neurology, Department of Pediatrics at Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background: To compare the clinical characteristics and outcomes of pediatric patients with refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) who received therapeutic hypothermia (TH) plus anticonvulsants or anticonvulsants alone.

Material And Methods: Two-medical referral centers, retrospective cohort study.

Setting: Pediatric Intensive Care Unit (PICU) at Taoyuan Chang Gung Children's hospital and Kaohsiung Chang Gung Memorial Hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.004DOI Listing

Surgical management of intraventricular hemorrhage and posthemorrhagic hydrocephalus in premature infants.

Authors:
Meng-Fai Kuo

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taiwan. Electronic address:

Perinatal intraventricular hemorrhage (IVH) with or without development of posthemorrhagic hydrocephalus (PHH) in premature neonates may lead to severe neurological disability. Although the percentage of preterm infants developing IVH has been greatly reduced in the last three decades, increased survival of these very immature infants has meant that large IVH with subsequent PHH is still a serious unsolved problem. Early cerebrospinal fluid diversion as a temporizing measure or a permanent shunt is the treatment of choice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.03.006DOI Listing

Pediatric abusive head trauma.

Authors:
Kun-Long Hung

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Department of Pediatrics, Fu Jen Catholic University Hospital, New Taipei City, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan. Electronic address:

Abusive head trauma (AHT), used to be named shaken baby syndrome, is an injury to the skull and intracranial components of a baby or child younger than 5 years due to violent shaking and/or abrupt impact. It is a worldwide leading cause of fatal head injuries in children under 2 years. The mechanism of AHT includes shaking as well as impact, crushing or their various combinations through acceleration, deceleration and rotational force. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.03.008DOI Listing

Neurocritical care for Anti-NMDA receptor encephalitis.

Biomed J 2020 Apr 21. Epub 2020 Apr 21.

Division of Pediatric Critical Care and Pediatric Neurocritical Care Center, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

In this review, we summarize the clinical presentations of the acute stage of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis and the neurocritical care strategy in intensive care units. Anti-NMDA receptor encephalitis has characteristic clinical features and is predominantly seen in young adults and children. Most patients have five stages of clinical presentation, including a prodromal phase, psychotic and/or seizure phase, unresponsive and/or catatonic phase, hyperkinetic phase, and gradual recovery phase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2020.04.002DOI Listing

Novel Bi-allelic PDE6C Variant Leads to Congenital Achromatopsia.

Iran Biomed J 2020 07 28;24(4):257-63. Epub 2020 Dec 28.

Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: The clinical phenotyping of patients with achromatopsia harboring variants in phosphordiesterase 6C (PDE6C) has poorly been described in the literature. PDE6C encodes the catalytic subunit of the cone phosphodiesterase, which hydrolyzes the cyclic guanosine monophosphate that proceeds with the hyperpolarization of photoreceptor cell membranes, as the final step of the phototransduction cascade.

Methods: In the current study, two patients from a consanguineous family underwent full ophthalmologic examination and molecular investigations including WES. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.257DOI Listing

Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats' Kidney, Lung, and Serum.

Iran Biomed J 2020 07 10;24(4):251-6. Epub 2020 Feb 10.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Background: The present study aimed to evaluate the effects of different concentrations of cerium oxide nanoparticles (CONPs) on the oxidative stress (OS) status in kidney, lung, and serum of rats.

Methods: Male Wistar Rats were treated intraperitoneally with 15, 30, and 60 mg/kg/day of CONPs. The biochemical parameters, including total antioxidant capacity (TAC), total thiol group (TTG), malondialdehyde (MDA), SOD (superoxide dismutase), and catalase (CAT) were assayed in serum, kidney, and lung tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.251DOI Listing

Carvacrol and Thymol Attenuate Cytotoxicity Induced by Amyloid β25-35 via Activating Protein Kinase C and Inhibiting Oxidative Stress in PC12 Cells.

Iran Biomed J 2020 07 22;24(4):243-50. Epub 2020 Jan 22.

Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.

Background: Our previous findings indicated that carvacrol and thymol alleviate cognitive impairments caused by Aβ in rodent models of Alzheimer's disease (AD). In this study, the neuroprotective effects of carvacrol and thymol against Aβ25-35-induced cytotoxicity were evaluated, and the potential mechanisms were determined.

Methods: PC12 cells were pretreated with Aβ25-35 for 2 h, followed by incubation with carvacrol or thymol for additional 48 h. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.243DOI Listing

Enhanced Adipose Mesenchymal Stem Cells Proliferation by Carboxymethyl-Chitosan Functionalized Polycaprolactone Nanofiber.

Iran Biomed J 2020 07 12;24(4):236-42. Epub 2020 Feb 12.

Universitatsstraße Bayreuth, Germany-Universitatsstraße Bayreuth, Germany.

Background: Through combining two synthetic and natural polymers, scaffolds can be developed for tissue engineering and regenerative medicine purposes.

Methods: In this work, carboxymethyl chitosan (CMC; 20%) was grafted to Polycaprolactone (PCL) nanofibers using the cold atmospheric plasma of helium. The PCL scaffolds were exposed to CAP, and functional groups were developed on the PCL surface. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.236DOI Listing

Assessment of Probiotics Mixture on Memory Function, Inflammation Markers, and Oxidative Stress in an Alzheimer's Disease Model of Rats.

Iran Biomed J 2020 07 29;24(4):220-8. Epub 2020 Feb 29.

Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: The most important cause of neurodegeneration in Alzheimer's disease (AD) is associated with inflammation and oxidative stress. Probiotics are microorganisms that are believed to be beneficial to human and animals. Probiotics reduce oxidative stress and inflammation in some cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.220DOI Listing

The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice.

Iran Biomed J 2020 07 10;24(4):214-9. Epub 2020 Feb 10.

Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Gonabad University of Medical Sciences, Gonabad, Iran.

Background: TGF-β has long been considered as the main inducer of Tregs in tumor microenvironment and is the reason for the aberrant number of Tregs in tumor-bearing individuals. Recently, it has been suggested that the enzyme arginase I is able to mediate the induction of Tregs in a TGF-β-independent fashion. The recombinant WW2/WW3 domains from smad ubiquitination regulatory factor 2 molecule was demonstrated to increase TGF-β signaling while reducing arginase I gene expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.214DOI Listing

The Significance of Biobanking in the Sustainability of Biomedical Research: A Review.

Iran Biomed J 2020 07 12;24(4):206-13. Epub 2020 Feb 12.

Shiraz Institute for Cancer Research, School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Biobank, defined as a functional unit for facilitating and improving research by storing biospecimen and their accompanying data, is a key resource for advancement in life science. The history of biobanking goes back to the time of archiving pathology samples. Nowadays, biobanks have considerably improved and are classified into two categories: diseased-oriented and population-based biobanks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.206DOI Listing

While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value.

Iran Biomed J 2020 07 19;24(4):229-35. Epub 2020 Apr 19.

Department of Genetics and Molecular Medicine, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan 45139-56111, Iran.

Background: Numerous studies confirmed that significant decrease in tissue decorin (DCN) expression is associated to tumor progression and metastasis in certain types of cancer including prostate cancer (PC). However, the potential prognostic value of tissue DCN in PC has not yet been investigated.

Methods: A total number of 40 PC and 42 patients with benign prostatic hyperplasia (BPH) were investigated for the expression levels of DCN in their prostatic tissues using real-time quantitative polymerase chain reaction and immunohistochemical analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29252/ibj.24.4.229DOI Listing

Necrotizing fasciitis of the entire head and neck: Literature review and case report.

Biomed J 2020 Feb 27;43(1):94-98. Epub 2020 Feb 27.

Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Necrotizing fasciitis (NF) is uncommon but potentially lethal when it is associated with systemic disorders. We report a case of odontogenic NF in a patient with uncontrolled diabetes mellitus. The patient was referred on day 10 since the onset of odontogenic NF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090320PMC
February 2020

Prognostic study for isolated local recurrence operated with salvage excision in hormone-receptor-positive patients with invasive breast cancer after primary breast surgery.

Biomed J 2020 Feb 21;43(1):83-93. Epub 2020 Feb 21.

Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: This study aimed to identify the factors that predict distant recurrence and survival outcome after patients with primary positive hormone receptor-positive (HR+) invasive breast cancer undergo complete excision for isolated local recurrence (ILR).

Methods: From January 2000 to December 2009, we performed a retrospective review of our database and identified 51 patients with HR + invasive breast cancer who underwent complete excision for ILR as a component of salvage therapy. The distant metastasis-free survival (DMFS) and overall survival (OS) from the time of ILR were calculated using the Kaplan-Meier method, and a Cox regression model was used for multivariate analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090316PMC
February 2020

CRISPR-Cas12a: Functional overview and applications.

Biomed J 2020 Feb 5;43(1):8-17. Epub 2020 Feb 5.

Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen, Denmark. Electronic address:

Prokaryotes have developed an adaptive immune system called Clustered regularly interspaced short palindromic repeats (CRISPR) to combat attacks by foreign mobile genetic elements (MGEs) such as plasmids and phages. In the past decade, the widely characterized CRISPR-Cas9 enzyme has been redesigned to trigger a genome editing revolution. Class II type V CRISPR-Cas12a is a new RNA guided endonuclease that has been recently harnessed as an alternative genome editing tool, which is emerging as a powerful molecular scissor to consider in the genome editing application landscape. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090318PMC
February 2020

A quantitative validation of segmented colon in virtual colonoscopy using image moments.

Biomed J 2020 Feb 25;43(1):74-82. Epub 2020 Feb 25.

Computer Science & Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, India.

Background: Evaluation of segmented colon is one of the challenges in Computed Tomography Colonography (CTC). The objective of the study was to measure the segmented colon accurately using image processing techniques.

Methods: This was a retrospective study, and the Institutional Ethical clearance was obtained for the secondary dataset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090282PMC
February 2020

Measuring patient-reported outcomes in orthognathic surgery: Linguistic and psychometric validation of the Mandarin Chinese version of FACE-Q instrument.

Biomed J 2020 Feb 4;43(1):62-73. Epub 2020 Mar 4.

Department of Plastic and Reconstructive Surgery and Craniofacial Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Orthognathic surgery is useful for correction of dental malocclusion and improvement of facial appearance. The FACE-Q is a patient-reported outcome instrument for evaluation of surgical and psychosocial effect. The purposes of this study were to conduct a linguistic validation of all FACE-Q scales to Mandarin Chinese, to test the orthognathic surgery-related scales for reliability and validity, and to evaluate the effect of orthognathic surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090319PMC
February 2020

Long-term therapeutic outcomes of papillary thyroid carcinoma with concomitant hyperparathyroidism: A single center case-control study.

Biomed J 2020 Feb 27;43(1):53-61. Epub 2020 Feb 27.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Papillary thyroid carcinoma occasionally presents with concomitant hyperparathyroidism; however, the clinical significance has not been well established. This study aimed to evaluate the long-term cancer prognosis following a multimodality therapy.

Methods: We conducted a case-control study using prospectively maintained data from a medical center thyroid cancer database between 1980 and 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090315PMC
February 2020

Novel human models for elucidating mechanisms of rate-sensitive H-reflex depression.

Biomed J 2020 Feb 26;43(1):44-52. Epub 2020 Feb 26.

Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, IA, USA. Electronic address:

Background: This study used novel human neurophysiologic models to investigate whether the mechanism of rate-sensitive H-reflex depression lies in the pre-synaptic or post-synaptic locus in humans. We hypothesized that pre-synaptic inhibition would suppress Ia afferents and H-reflexes without suppressing alpha motor neurons or motor evoked potentials (MEPs). In contrast, post-synaptic inhibition would suppress alpha motor neurons, thereby reducing H-reflexes and MEPs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bj.2019.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090317PMC
February 2020