865 results match your criteria Biomedical Journal[Journal]


The dual role of innate immunity during influenza.

Biomed J 2019 Feb 20;42(1):8-18. Epub 2019 Mar 20.

Metchnikoff Laboratory, University of Messina, Messina, Italy. Electronic address:

One of the distinguishing features of the 1918 pandemic is the occurrence of massive, potentially detrimental, activation of the innate immune system in critically ill patients. Whether this reflects an intrinsic capacity of the virus to induce an exaggerated inflammatory responses or its remarkable ability to reproduce in vivo is still open to debate. Tremendous progress has recently been made in our understanding of innate immune responses to influenza infection and it is now time to translate this knowledge into therapeutic strategies, particularly in view of the possible occurrence of future outbreaks caused by virulent strains. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170183064
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http://dx.doi.org/10.1016/j.bj.2018.12.009DOI Listing
February 2019
1 Read

Impact of age on pathological complete response and locoregional recurrence in locally advanced breast cancer after neoadjuvant chemotherapy.

Biomed J 2019 Feb 28;42(1):66-74. Epub 2019 Mar 28.

Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address:

Background: Neoadjuvant chemotherapy (NAC) is the standard approach for downstaging of locally advanced breast cancer and can improve breast conservation rates. A pathological complete response (pCR) after NAC associated with favorable long-term outcomes has been described. There is still a high locoregional recurrence (LRR) rate after NAC and the influence of age on LRR after NAC is unclear. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.007DOI Listing
February 2019
1 Read

Diagnostic pitfalls and therapeutic outcomes of the macrofollicular variant of papillary thyroid carcinoma.

Biomed J 2019 Feb 20;42(1):59-65. Epub 2019 Mar 20.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan. Electronic address:

Background: The macrofollicular variant of papillary thyroid cancer (MFVPTC) is a rare histological variant of papillary thyroid cancer (PTC), with only 71 cases reported through 2014. This study analyzed the clinical, preoperative thyroid ultrasonography (US), and fine needle aspiration cytology (FNAC) features; and therapeutic outcomes of 11 patients with MFVPTC.

Methods: The records of 393 patients with histologically diagnosed follicular variant of papillary thyroid carcinoma (FVPTC), including 11 with MFVPTC, were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.bj.2018.12.006DOI Listing
February 2019
1 Read

Evaluation of the fracture resistance of root filled thin walled teeth restored with different post systems.

Biomed J 2019 Feb 20;42(1):53-58. Epub 2019 Mar 20.

Dentarma Dental Clinic, Eskişehir, Turkey.

Background: Restoration of the teeth with extensive root canals with different post systems is a challenge for clinicians. Evaluation of these systems is important for clinical success. The aim of this study was to compare the fracture resistance and fracture mode of endodontically treated thin-walled teeth which restored with different post systems. Read More

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http://dx.doi.org/10.1016/j.bj.2018.12.003DOI Listing
February 2019

Legacy of the influenza pandemic 1918: Introduction.

Authors:
Siamon Gordon

Biomed J 2019 Feb 28;42(1):5-7. Epub 2019 Feb 28.

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Exeter College Emeritus Fellow in Pathology, and Emeritus GlaxoWellcome Professor of Cellular Pathology, University of Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bj.2019.01.006DOI Listing
February 2019

Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: A clinical trial.

Biomed J 2019 Feb 20;42(1):46-52. Epub 2019 Mar 20.

Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Otolaryngology, Chang Gung Memorial Hospital and Xiamen Medical Center, Fujian, China. Electronic address:

Background: Zinc plays a vital antioxidant role in human metabolism. Recent studies have demonstrated a correlation between noise-induced hearing loss (NIHL) and oxidative injury; however, no investigation has focused specifically on the subgroup of NIHL associated tinnitus patients. We aimed to evaluate the effectiveness of zinc supplementation in treating NIHL associated tinnitus. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.009DOI Listing
February 2019

The protective role of IL-1Ra on intestinal ischemia reperfusion injury by anti-oxidative stress via Nrf2/HO-1 pathway in rat.

Biomed J 2019 Feb 27;42(1):36-45. Epub 2019 Mar 27.

Institute of Military Cognitive and Brain Sciences, Academy of Military Medical Sciences, Beijing, PR China; Anhui Medical University, Hefei, PR China. Electronic address:

Background: Intestinal ischemia reperfusion injury is a frequent clinical damage, in which the oxidative stress and inflammation play an important role. Interleukin-1 receptor antagonist (IL-1Ra) is a natural anti-inflammatory factor, however, its effect on intestinal ischemia reperfusion injury remains unclear.

Methods: The rat model of intestinal I/R was induced by occlusion (for 60 min) and reopening (for 60 min) of superior mesenteric artery. Read More

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http://dx.doi.org/10.1016/j.bj.2018.11.001DOI Listing
February 2019
1 Read

Association between periodontal pathogens and systemic disease.

Biomed J 2019 Feb 2;42(1):27-35. Epub 2019 Mar 2.

Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA. Electronic address:

A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170183026
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http://dx.doi.org/10.1016/j.bj.2018.12.001DOI Listing
February 2019
1 Read

IFITM3: How genetics influence influenza infection demographically.

Biomed J 2019 Feb 20;42(1):19-26. Epub 2019 Mar 20.

MRC Human Immunology Unit, WIMM, University of Oxford, OX3 9DS, UK; CAMS Oxford Institute, Nuffield Department of Medicine, Oxford University, OX3 9FZ, UK. Electronic address:

The role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence. In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170183056
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http://dx.doi.org/10.1016/j.bj.2019.01.004DOI Listing
February 2019
1 Read

Evergreen influenza - Tackling an old enemy with fresh munitions.

Biomed J 2019 Feb;42(1):1-4

Anders Lund Group, BRIC Biotech Research & Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen, Denmark. Electronic address:

This special edition of the Biomedical Journal puts the innate immune system into the limelight. We learn about the universal mechanisms underlying the immediate defense against influenza viruses mounted by innate immunity but also its detrimental secondary effects and how differential host genetics influence the network. Moreover, this issue addresses how oral hygiene is a concern for the entire organism, that younger age goes well with neoadjuvant chemotherapy for breast cancer and zinc with feeling less distressed by tinnitus caused by noise-induced hearing loss, and that IL-1Ra holds very promising potential to prevent intestinal ischemia reperfusion injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170193013
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http://dx.doi.org/10.1016/j.bj.2019.02.005DOI Listing
February 2019
2 Reads

Pharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice after Intravenous and Oral Administration

Iran Biomed J 2019 Apr 7. Epub 2019 Apr 7.

Research Department, Laboratories of Biopharmaceuticals and Chemistries Productions (LABIOFAM), Havana, Cuba.

Background: Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice.

Methods: 131I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12. Read More

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Physicochemical Position-Dependent Properties in the Protein Secondary Structures

Iran Biomed J 2019 Apr 7. Epub 2019 Apr 7.

Department of Bioelectronic and Biomedical Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Establishing theories for designing arbitrary protein structures is complicated and depends on understanding the principles for protein folding, which is affected by applied features. Computer algorithms can reach high precision and stability in computationally designed enzymes and binders by applying informative features obtained from natural structures.

Methods: In this study, a position-specific analysis of secondary structures (α-helix, β-strand, and tight turn) was performed to reveal novel features for protein structure prediction and protein design. Read More

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Identification of a Novel KCNQ1 Frameshift Mutation and Review of the Literature among Iranian Long QT Families

Iran Biomed J 2019 05 24;23(3):228-34. Epub 2019 Feb 24.

Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Background: Long QT syndrome (LQTS) is characterized by the prolongation of QT interval, which results in syncope and sudden cardiac death in young people. KCNQ1 is the most common gene responsible for this syndrome.

Methods: Molecular investigation was performed by DNA Sanger sequencing in Iranian families with a history of syncope. Read More

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May 2019
3 Reads

Effects of Environmental Conditions on High-Yield Magnetosome Production by Magnetospirillum gryphiswaldense MSR-1

Iran Biomed J 2019 05 24;23(3):209-19. Epub 2019 Feb 24.

Hybridoma Lab., Department of immunology, Pasteur Institute of Iran, Tehran, Iran.

Background: Magnetotactic bacteria are a heterogeneous group of Gram-negative prokaryote cells that produce linear chains of magnetic particles called magnetosomes, intracellular organelles composed of magnetic iron particles. Many important applications have been defined for magnetic nanoparticles in biotechnology, such as cell separation applications, as well as acting as carriers of enzymes, antibodies, or anti-cancer drugs. Since the bacterial growth is difficult and the yield of magnetosome production is low, the application of magnetosome has not been developed on a commercial scale. Read More

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Distribution of the CM-Dil-Labeled Human Umbilical Cord Vein Mesenchymal Stem Cells Migrated to the Cyclophosphamide-Injured Ovaries in C57BL/6 Mice

Iran Biomed J 2019 05 24;23(3):200-8. Epub 2019 Feb 24.

Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background: Mesenchymal stem cells (MSCs) can be used to treat premature ovarian failure (POF). Different methods have already been applied to detect MSCs in tissues. This study aimed to investigate the quantitative distribution of CM-DiI-labeled human umbilical cord vein MSCs (hUCV-MSCs) in different regions of the ovarian tissue of the cyclophosphamide (CTX)-induced POF in mice. Read More

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May 2019
1 Read

Factor VII Gene Defects: Review of Functional Studies and Their Clinical Implications

Iran Biomed J 2019 05 24;23(3):165-74. Epub 2019 Feb 24.

Molecular Medicine Department, Pasteur Institute of Iran, Tehran, Iran.

Coagulation factors belong to a family of plasma glycosylated proteins that should be activated for appropriate blood coagulation. Congenital deficiencies of these factors cause inheritable hemorrhagic diseases. Factor VII (FVII) deficiency is a rare bleeding disorder with variable clinical symptoms. Read More

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Commentary: Lico A causes ER stress and apoptosis via up-regulating miR-144-3p in human lung cancer cell line H292.

Biomed J 2018 12 2;41(6):391-392. Epub 2019 Jan 2.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Natural compound licochalcone A (lico A), a main constituent of flavonoids, has been proved to induce ER stress and apoptosis in cancer cells. However, the underlying anti-tumor mechanism of lico A remains to be clarified in detail. A recently-published report from the journal Frontiers in Pharmacology evaluated the miRNA-based mechanism for lico A on its anti-cancer effect. Read More

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http://dx.doi.org/10.1016/j.bj.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362273PMC
December 2018
1 Read

Surgical technique to achieve high durability of flexible ureteroscopes: A single hospital experience.

Biomed J 2018 12 11;41(6):385-390. Epub 2019 Jan 11.

Department of Urology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan. Electronic address:

Background: To describe a novel operative technique resulting in extended durability and improved ease of use of current flexible ureteroscopes (FURS). A surgical method employing a modified technique of using an Olympus digital flexible URF-V ureteroscope was developed.

Methods: We retrospectively studied 546 patients who underwent retrograde intrarenal surgery (RIRS) using this modified approach performed by a single surgeon at our hospital, and investigated the outcome and durability of the ureteroscope. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362256PMC
December 2018
1 Read

Lifestyle characteristics as moderators of the effectiveness of weight control interventions among semiconductor workers.

Biomed J 2018 12 18;41(6):376-384. Epub 2019 Jan 18.

Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Laboratory for Epidemiology, Department of Health Care Management, Chang Gung University, Taoyuan, Taiwan; Department of Emergency Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Urology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Safety, Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, Taiwan. Electronic address:

Background: Workers in high technology industry are experiencing stressful environment and have been ranked as a high risk group for adverse health effects. The effectiveness of worksite health promotion is important for occupational health. This study is to investigate the effect of health interventions on body measurement changes while examining the role of their lifestyle factors. Read More

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http://dx.doi.org/10.1016/j.bj.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361846PMC
December 2018
1 Read

Relationship between sonography of sternocleidomastoid muscle and cervical passive range of motion in infants with congenital muscular torticollis.

Biomed J 2018 12 4;41(6):369-375. Epub 2019 Jan 4.

Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Chiayi, Chiayi, Taiwan.

Background: An abnormal sternocleidomastoid muscle in congenital muscular torticollis can be classified into one of the four types via sonography. However, this categorization lacks quantitative measurements. The purpose of the study was to determine quantitative measurements of the sonograms via image analysis. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361856PMC
December 2018
1 Read

Effects of bilateral or unilateral lower body resistance exercises on markers of skeletal muscle damage.

Biomed J 2018 12 2;41(6):364-368. Epub 2019 Jan 2.

Department of Biostatistics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. Electronic address:

Background: It is known that different intensity exercises create skeletal muscle damage at different levels. The purpose of the study was to compare effects of bilateral or unilateral lower body resistance exercise on markers of skeletal muscle damage.

Methods: The Brzycki Formula was used to calculate participants' one repetition maximum strength for each movement and limb, separately. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361852PMC
December 2018

Subjective and objective assessments of sleep problems in children with attention deficit/hyperactivity disorder and the effects of methylphenidate treatment.

Biomed J 2018 12 11;41(6):356-363. Epub 2019 Jan 11.

Department of Psychiatry, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: to investigate the sleep problems in children with different ADHD presentations and effects of methylphenidate (MPH) on the sleep problems of children with ADHD by both subjective and objective measurements.

Methods: 71 children with ADHD and 30 controls were included. 35 had ADHD with predominantly inattentive presentation (ADHD-I) and 36 with predominantly hyperactive/impulsive or combined presentation (ADHD-C). Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362263PMC
December 2018
4 Reads

Association of diabetic ketoacidosis, severe hypoglycemia and glycemic control among children and young adults with type 1 diabetes mellitus treated with premixed versus basal-bolus insulin therapy.

Biomed J 2018 12 11;41(6):348-355. Epub 2019 Jan 11.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: This study compared event rates of diabetic ketoacidosis (DKA) and severe hypoglycemia, as well as glycemic control, among children, adolescents, and young adults with type 1 diabetes mellitus (T1DM) receiving basal-bolus or premixed insulin therapy.

Methods: A total of 825 individuals aged ≤ 20 years with T1DM, using either basal-bolus or premixed insulin regimens, were retrospectively recruited from 2001 to 2015. Rates of DKA after diagnosis, severe hypoglycemia, and the level of glycated hemoglobin A1c (HbA1c) improvement during the follow-up period were analyzed. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363560PMC
December 2018
1 Read

Effects of standardized Zataria multiflora extract and its major ingredient, Carvacrol, on Adriamycin-induced hepatotoxicity in rat.

Biomed J 2018 12 11;41(6):340-347. Epub 2019 Jan 11.

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Due to antioxidant effects of Zataria multiflora (ZM) and Carvacrol (CAR) in many cases and the prominent role of reactive oxygen species (ROS) in hepatotoxicity induced by Adriamycin (ADR), the aim of this study is to investigate the effects of ZM and CAR on ADR-induced hepatotoxicity.

Methods: Twenty four male Wistar rats were randomly divided into four groups including: 1)Control, 2)Adriamycin (ADR), 3,4) ZM + ADR and CAR + ADR that received ZM and CAR for 28 consecutive days. Blood samples were collected on the days 0, 14 and 28 to determine the alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362159PMC
December 2018

Basal-bolus or premixed? Shedding light on optimal insulin regime for type 1 diabetes.

Biomed J 2018 12 18;41(6):337-339. Epub 2019 Jan 18.

Staff Writer at the Biomedical Journal, 56 Dronningens Gate, 7012 Trondheim, Norway. Electronic address:

In this issue of the Biomedical Journal, we highlight original research that will help to guide the choice of insulin administration regimes for children with type 1 diabetes. We also investigate whether a common medication for attention deficit/hyperactivity disorder worsens sleep problems among these children, and discover a new approach to maximize the lifetime of a fragile piece of surgical equipment. Read More

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http://dx.doi.org/10.1016/j.bj.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362169PMC
December 2018
1 Read

Comparison of OmpA Gene-Targeted Real-Time PCR with the Conventional Culture Method for Detection of Acinetobacter baumanii in Pneumonic BALB/c Mice

Iran Biomed J 2019 03;23(2):159-64

Dept. of Cell Biology, Science and Research branch, Islamic Azad University, Tehran, Iran.

Background: Acinetobacter baumannii is an important pathogen in health care and is responsible for severe nosocomial and community-acquired pneumonia. To design novel therapeutic agents, a mouse model for A. baumannii pneumonia is essential. Read More

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March 2019
7 Reads

Size scaling of nucleolus in Caenorhabditis elegans embryos.

Biomed J 2018 10 6;41(5):333-336. Epub 2018 Nov 6.

Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Nucleolus is viewed as a plurifunctional center in the cell, tightly linked to ribosome biosynthesis. As a non-membranous structure, how the size of nucleolus is determined is a long outstanding question, and the possibility of "direct size scaling to the nucleus" was raised by genetic studies in fission yeast. Here, we used the model organism Caenorhabditis elegans to test this hypothesis in multi-cellular organisms. Read More

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http://dx.doi.org/10.1016/j.bj.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306298PMC
October 2018
3 Reads

The streptozotocin-high fat diet induced diabetic mouse model exhibits severe skin damage and alterations in local lipid mediators.

Biomed J 2018 10 3;41(5):328-332. Epub 2018 Nov 3.

Faculty of Biological Sciences, Department of Physiology, Pontifical Catholic University of Chile, Santiago, Chile.

Background: Type 2 diabetes (T2D) can go undiagnosed for years, leading to a stage where produces complications such as delayed skin wound healing. Animal models have been developed in the last decades to study the pathological progression in this disease. Streptozotocin (STZ), that has a selective pharmacological toxicity toward pancreatic β cells, in addition to high fat diet has been widely used to induce diabetes however no evidence has shown its effects on the skin integrity. Read More

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http://dx.doi.org/10.1016/j.bj.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306302PMC
October 2018
2 Reads

Defining polytrauma by abbreviated injury scale ≥ 3 for a least two body regions is insufficient in terms of short-term outcome: A cross-sectional study at a level I trauma center.

Biomed J 2018 10 6;41(5):321-327. Epub 2018 Nov 6.

Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taiwan.

Background: Patients with polytrauma are expected to have a higher risk of mortality than the summation of expected mortality for their individual injuries. This study was designed to investigate the outcome of polytrauma patients, diagnosed by abbreviated injury scale (AIS) ≥ 3 for at least two body regions, at a level I trauma center.

Methods: Detailed data of 694 polytrauma patients and 2104 non-polytrauma patients with an overall Injury Severity Score (ISS) ≥ 16 and hospitalized between January 1, 2009, and December 31, 2014 for treatment of all traumatic injuries, were retrieved from the Trauma Registry System. Read More

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http://dx.doi.org/10.1016/j.bj.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306305PMC
October 2018
1 Read

Secular trends in incidence of osteoporosis in Taiwan: A nationwide population-based study.

Biomed J 2018 10 3;41(5):314-320. Epub 2018 Nov 3.

Department of Medical Research and Development, Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: The present study aimed to assess the changes in trend of osteoporosis among the Taiwanese population from 2001 to 2011.

Methods: The National Health Insurance Research Database (NHIRD) of Taiwan, containing records from approximately 23 million insures from 2001 to 2011, was analyzed. Insurees aged≧50 years with osteoporosis were identified either from previously documented osteoporotic diagnosis or osteoporosis-related fractures according to Clinical Modification (ICD-9-CM) diagnostic code. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170163031
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http://dx.doi.org/10.1016/j.bj.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306299PMC
October 2018
11 Reads

Factors related to post surgical neurologic improvement for cervical spine infection.

Biomed J 2018 10 5;41(5):306-313. Epub 2018 Nov 5.

Department of Orthopaedic Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address:

Background: Cervical spine infections are uncommon but potentially dangerous, having the highest rate of neurological compromise and resulting disability. However, the factors related to surgical success is multiple yet unclear.

Methods: We retrospectively reviewed the medical records of 27 patients (16 men and 11 women) with cervical spine infection who underwent surgical treatment at Chang Gung Memorial Hospital, Linkou branch, between 2001 and 2014. Read More

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http://dx.doi.org/10.1016/j.bj.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306300PMC
October 2018
2 Reads

Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra.

Biomed J 2018 10 23;41(5):298-305. Epub 2018 Nov 23.

Center for Biological and Health Sciences, Graduate Program in Physiological Sciences, Federal University of Sergipe, Itabaiana, SE, Brazil.

Geraniol is a monoterpene alcohol that is derived from the essential oils of aromatic plants, with anti-inflammatory, antimicrobial, antioxidant and neuroprotective properties. This study characterized the effect of geraniol on behavior and brainwave patterns in rats. Male rats were submitted to administration of geraniol (25, 50 and 100 mg/kg). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170173027
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http://dx.doi.org/10.1016/j.bj.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306311PMC
October 2018
8 Reads

Improved osteogenic differentiation of umbilical cord blood MSCs using custom made perfusion bioreactor.

Biomed J 2018 10 16;41(5):290-297. Epub 2018 Nov 16.

Department of Biotechnology, National Institute of Technology Warangal, TS, India. Electronic address:

Background: 3D cell culture is an appropriate method to develop engineered bone tissue, where different bioreactors have been designed to mitigate the challenges in 3D culture. Currently, we tailored a perfusion reactor to witness human mesenchymal stem cells (MSCs) proliferation and differentiation over polylactic acid-polyethylene glycol (PLA/PEG) composite scaffolds.

Methods: The composite scaffolds with different weight ratios of PLA and PEG were prepared using solvent casting-particulate leaching technique. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170173034
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http://dx.doi.org/10.1016/j.bj.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306301PMC
October 2018
12 Reads

Dengue outbreaks and the geographic distribution of dengue vectors in Taiwan: A 20-year epidemiological analysis.

Authors:
Wei-June Chen

Biomed J 2018 10 9;41(5):283-289. Epub 2018 Nov 9.

Department of Public Health and Parasitology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address:

Dengue fever is an important mosquito-borne viral infectious disease that mostly occurs in tropical and subtropical areas of the world. According to epidemiological data from the Center for Disease Control of Taiwan, more than 98.62% of outbreaks of indigenous total dengue cases were reported in the southern part of Taiwan. Read More

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http://dx.doi.org/10.1016/j.bj.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306330PMC
October 2018
1 Read

Dengue in Taiwan: Pointing the finger at Aedes aegypti.

Biomed J 2018 10 12;41(5):279-282. Epub 2018 Nov 12.

Staff Writer at the Biomedical Journal, 56 Dronningens Gate, 7012 Trondheim, Norway. Electronic address:

In this issue of the Biomedical Journal we explore the history of dengue infection in Taiwan and what current trends have to say about the vector responsible for transmitting the disease on the island. We focus on original research reporting the development of a new perfusion bioreactor to engineer bone from human cord blood stem cells. Finally, we look at trends in osteoporosis in Taiwan and how they highlight the success of public health campaigns. Read More

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http://dx.doi.org/10.1016/j.bj.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306303PMC
October 2018
16 Reads

Immunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse Trend

Iran Biomed J 2019 03 3;23(2):107-20. Epub 2018 Dec 3.

HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Background: Two of the Wnt signaling pathway target genes, tumor necrosis factor receptor family member (TROY) and leucine-rich G-protein coupled receptor (LGR5), are involved in the generation and maintenance of gastrointestinal epithelium. A negative modulatory role has recently been assigned to TROY, in this pathway. Here, we have examined their simultaneous expression in gastric carcinogenesis. Read More

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March 2019
1 Read

Bioprinting in Vascularization Strategies

Iran Biomed J 2019 01;23(1):9-20

National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.

Three-dimensional (3D) printing technology has revolutionized tissue engineering field because of its excellent potential of accurately positioning cell-laden constructs. One of the main challenges in the formation of functional engineered tissues is the lack of an efficient and extensive network of microvessels to support cell viability. By printing vascular cells and appropriate biomaterials, the 3D printing could closely mimic in vivo conditions to generate blood vessels. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305822PMC
January 2019
11 Reads

Study Break: Recent Advances in Hemophilia Gene Therapy

Authors:
M Karimipoor

Iran Biomed J 2019 01 17;23(1):7-8. Epub 2018 Nov 17.

Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305819PMC
January 2019
14 Reads

Hydroalcoholic Extract of Levisticum officinale Increases cGMP Signaling Pathway by Down-Regulating PDE5 Expression and Induction of Apoptosis in MCF-7 and MDA-MB-468 Breast Cancer Cell Lines

Iran Biomed J 2018 Nov 3. Epub 2018 Nov 3.

Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.

Background: This study aimed to investigate Levisticum officinale hydroalcoholic extract (LOHE) effect on both cGMP signaling pathway and phosphodiesterase 5 (PDE5) gene expression pattern and to examine the role of LOHE in apoptosis induction of MCF-7 and MDA-MB-468 cell lines.

Methods: The half maximal inhibitory concentration (IC50) of LOHE was examined in both cell lines using the MTT assay. Using IC50 values of LOHE on both cells, the type of cell death was detected by flowcytometric analysis. Read More

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November 2018

Exogenous Nitric Oxide Induced Early Mineralization in Rat Bone Marrow Mesenchymal Stem Cells via Activation of Alkaline Phosphatase

Iran Biomed J 2019 03 31;23(2):142-52. Epub 2018 Oct 31.

Department of Biology, Faculty of Sciences, Markazi, Iran

Background: Since the low concentration and short-time treatment with sodium nitroprusside (SNP), a nitric oxide (NO)–donor, cause no harm to rat bone marrow mesenchymal stem cells (MSCs), we studied the impact of SNP on MSCs differentiation.

Methods: MSCs were treated with 100 and 1000 µM of SNP for 1 hour in every 48 hours and after 5, 10, 15, and 21 days in osteogenic media. The viability and the level of mineralization were determined using MTT assay and alizarin red staining, respectively. Read More

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March 2019
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Comparison of the Utility of Recombinant B8/2 Subunit of the Antigen B, Native Antigen, and a Commercial ELISA Kit in the Diagnosis of Human Cystic Echinococcosis

Iran Biomed J 2018 Oct 28. Epub 2018 Oct 28.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Cystic echinococcosis (CE) is a helminthic disease caused by the larval form of Echinococcus granulosus. In the present study, the B8/2 subunit of antigen B (AgB) of E. granulosus was expressed in E. Read More

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October 2018
3 Reads

Adaptation and validation of a measure of health literacy in Taiwan: The Newest Vital Sign.

Biomed J 2018 08 14;41(4):273-278. Epub 2018 Sep 14.

Department of Health Care Management, College of Management, Chang Gung University, Taoyuan, Taiwan.

Background: Health literacy (HL) refers to the ability to obtain, read, understand, and use basic health care information required to make appropriate health decisions and follow instructions for treatment. The Newest Vital Sign (NVS) is an instrument developed for assessing aspects of HL relevant to reading and numeracy skills. This study aimed to develop a traditional Chinese version of the NVS (NVS-TC) and assess its feasibility, reliability, and validity in Taiwanese patients with type 2 diabetes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170173026
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http://dx.doi.org/10.1016/j.bj.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197990PMC
August 2018
12 Reads

Sutureless aortic bioprosthesis replacement in elderly Asian patients with aortic stenosis: Experience in a single institution.

Biomed J 2018 08 6;41(4):265-272. Epub 2018 Sep 6.

Department of Cardiothoracic and Vascular Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Sutureless aortic valve replacement (SU-AVR) has emerged as a promising alternative for the treatment of patients with aortic valve stenosis. This study aims to assess the safety and efficacy of SU-AVR in an elderly Asian population.

Methods: From June 2015 to May 2016, 15 adults with severe aortic stenosis (9 females) with a median age of 79 years underwent Perceval sutureless bioprosthesis (LivaNova, UK) implantation in a single Taiwanese institution; peri-operative recovery, clinical improvement, and valve performance were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170173021
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http://dx.doi.org/10.1016/j.bj.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198014PMC
August 2018
2 Reads

Evaluation of cell damage induced by irradiated Zinc-Phthalocyanine-gold dendrimeric nanoparticles in a breast cancer cell line.

Biomed J 2018 08 6;41(4):254-264. Epub 2018 Sep 6.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, Gauteng, South Africa. Electronic address:

Background: Cancer is a non-communicable disease that occurs following a mutation in the genes which control cell growth. Breast cancer is the most diagnosed cancer among South African women and a major cause of cancer-related deaths worldwide. Photodynamic therapy (PDT) is an alternative cancer therapy that uses photochemotherapeutic agents, known as photosensitizers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170173007
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http://dx.doi.org/10.1016/j.bj.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198017PMC
August 2018
9 Reads

Wearable sensors for the monitoring of movement disorders.

Authors:
Nahed Jalloul

Biomed J 2018 08 11;41(4):249-253. Epub 2018 Sep 11.

Department of Mechanical Engineering, American Uniersity of Beirut, Beirut, Lebanon. Electronic address:

This paper offers a review of the implementation of current wearable sensing technologies in monitoring the movement and activity of patients suffering from movement disorders. Recent literature has focused on incorporating simple and reliable wearable technologies for the continuous and objective monitoring of patient movement during normal daily activities. However, the use of such wearable sensing technologies has yet to find its way to clinical practice. Read More

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http://dx.doi.org/10.1016/j.bj.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198019PMC

Legacy of the influenza pandemic 1918: The host T cell response.

Biomed J 2018 08 11;41(4):242-248. Epub 2018 Sep 11.

Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Oxford, OX3 7FZ, UK. Electronic address:

The influenza virus was instrumental in unravelling critical aspects of the antiviral T lymphocyte mediated immune response. A major finding was the demonstration that CD8 T lymphocytes recognize short viral peptides presented by class I molecules of the major histocompatibility complex. Studies of influenza specific T cells have also led to an understanding of their important role in recovery from influenza virus infection in humans. Read More

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http://dx.doi.org/10.1016/j.bj.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197988PMC

Centennial review of influenza in Taiwan.

Biomed J 2018 08 10;41(4):234-241. Epub 2018 Sep 10.

Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan. Electronic address:

The history of influenza in Taiwan can be traced up to the 1918 H1N1 Spanish flu pandemic, followed by several others including the 1957 H2N2, 1968 H3N2, and the 2009 new H1N1. A couple of avian influenza viruses of H5N1 and H7N9 also posed threats to the general public in Taiwan in the two recent decades. Nevertheless, two seasonal influenza A viruses and two lineages of influenza B viruses continue causing annual endemics one after the other, or appearing simultaneously. Read More

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http://dx.doi.org/10.1016/j.bj.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197989PMC
August 2018
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The role of respiratory epithelium in host defence against influenza virus infection.

Biomed J 2018 08 10;41(4):218-233. Epub 2018 Sep 10.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address:

The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. Read More

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http://dx.doi.org/10.1016/j.bj.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197993PMC

Legacy of the influenza pandemic 1918: Introduction.

Authors:
Siamon Gordon

Biomed J 2018 08 10;41(4):215-217. Epub 2018 Sep 10.

Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Exeter College Emeritus Fellow in Pathology, and Emeritus GlaxoWellcome Professor of Cellular Pathology, University of Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bj.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197992PMC

The influenza chronicles: From the 1918 pandemic to current understanding of host defense mechanisms.

Biomed J 2018 08 20;41(4):211-214. Epub 2018 Sep 20.

Staff Writer at the Biomedical Journal, 56 Dronningens gate, 7012 Trondheim, Norway. Electronic address:

In this special edition of the Biomedical Journal, we learn about the battle between host and influenza virus at the respiratory epithelium, and how the history of influenza pandemics has driven both major advances in the understanding of immunology and planning for future outbreaks. We also learn of a nanoparticle system that holds promise for photodynamic therapy in breast cancer. Finally, we add evidence to the debate of the safety of a minimally invasive technique for aortic valve replacement in elderly patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23194170183045
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http://dx.doi.org/10.1016/j.bj.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197991PMC
August 2018
1 Read