Search Our Scientific Publications & Authors

Biomed Inform Insights 2019 4;11:1178222619885147. Epub 2019 Nov 4.

Berg LLC, Framingham, MA, USA.

Early diagnosis of sepsis and septic shock has been unambiguously linked to lower mortality and better patient outcomes. Despite this, there is a strong unmet need for a reliable clinical tool that can be used for large-scale automated screening to identify high-risk patients. We addressed the following questions: Can a novel algorithm to identify patients at high risk of septic shock 24 hours before diagnosis be discovered using available clinical data? What are performance characteristics of this predictive algorithm? Can current metrics for evaluation of sepsis be improved using novel algorithm? Publicly available data from the intensive care unit setting was used to build septic shock and control patient cohorts. Read More

Biomed Inform Insights 2019 17;11:1178222619881624. Epub 2019 Oct 17.

Department of Mathematics, Hong Kong University of Science and Technology, Hong Kong, China.

Statistical approaches for integrating multiple data sets in genome-wide association studies (GWASs) are increasingly important. Proper utilization of more relevant information is expected to improve statistical efficiency in the analysis. Among these approaches, LEP was proposed for joint analysis of individual-level data and summary-level data in the same population by leveraging pleiotropy. Read More

Biomed Inform Insights 2019 31;11:1178222619863369. Epub 2019 Jul 31.

Department of Biochemistry and Molecular Genetics, College of Medicine, The University of Illinois at Chicago, Chicago, IL, USA.

The purpose of this study was to test the hypothesis that infections are linked to chromosomal anomalies that cause neurodevelopmental disorders. In children with disorders in the development of their nervous systems, chromosome anomalies known to cause these disorders were compared with foreign DNAs, including known teratogens. Genes essential for neurons, lymphatic drainage, immunity, circulation, angiogenesis, cell barriers, structure, epigenetic and chromatin modifications were all found close together in polyfunctional clusters that were deleted or rearranged in neurodevelopmental disorders. Read More

Biomed Inform Insights 2019 28;11:1178222619829079. Epub 2019 May 28.

Department of Biomedical Informatics, University of Cincinnati, Cincinnati, OH, USA.

Objective: Medication dosing in pediatrics is complex and prone to errors that may lead to patient harm. To improve computer-assisted dosing, a mathematical model and algorithm were developed to optimize clinical decision support dosing rules and reduce spurious alerts. The objective was to evaluate the feasibility of using this algorithm to adjust dosing rules. Read More

Biomed Inform Insights 2019 18;11:1178222619835548. Epub 2019 Mar 18.

Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Objective: To demonstrate the usefulness of applying supervised machine-learning analyses to identify specific groups of patients that experience high levels of mortality post-interhospital transfer.

Methods: This was a cross-sectional analysis of data from the Health Care Utilization Project 2013 National Inpatient Sample, that applied supervised machine-learning approaches that included (1) classification and regression tree to identify mutually exclusive groups of patients and their associated characteristics of those experiencing the highest levels of mortality and (2) random forest to identify the relative importance of each characteristic's contribution to post-transfer mortality.

Results: A total of 21 independent groups of patients were identified, with 13 of those groups exhibiting at least double the national average rate of mortality post-transfer. Read More

Biomed Inform Insights 2019 8;11:1178222619832859. Epub 2019 Mar 8.

Departments of Pediatrics (Division of Systems Medicine), Psychiatry (by courtesy), and Biomedical Data Science, Stanford University, Stanford, CA, USA.

Studies on autism spectrum disorder (ASD) have amassed substantial evidence for the role of genetics in the disease's phenotypic manifestation. A large number of coding and non-coding variants with low penetrance likely act in a combinatorial manner to explain the variable forms of ASD. However, many of these combined interactions, both additive and epistatic, remain undefined. Read More

Biomed Inform Insights 2019 5;11:1178222619829083. Epub 2019 Mar 5.

Department of Psychiatry and Wellcome Centre for Ethics & Humanities, University of Oxford, Oxford, UK.

Over the last decade, there has been an explosion of digital interventions that aim to either supplement or replace face-to-face mental health services. More recently, a number of automated conversational agents have also been made available, which respond to users in ways that mirror a real-life interaction. What are the social and ethical concerns that arise from these advances? In this article, we discuss, from a young person's perspective, the strengths and limitations of using chatbots in mental health support. Read More

Biomed Inform Insights 2019 10;11:1178222618818478. Epub 2019 Jan 10.

Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.

Bedside monitors are intended as a safety net in patient care, but their management in the inpatient setting is a significant patient safety concern. The low precision of vital sign alarm systems leads to clinical staff becoming desensitized to the sound of the alarm, a phenomenon known as alarm fatigue. Alarm fatigue has been shown to increase response time to alarms or result in alarms being ignored altogether and has negative consequences for patient safety. Read More

Biomed Inform Insights 2018 13;10:1178222618816097. Epub 2018 Dec 13.

The Old Schools, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Homeless people experience a unique set of challenges leading to pervasive health and social problems. An increasing number of researchers have harnessed photographic data to gain a unique perspective of marginalised groups. The aim of the study is to explore the feasibility of using photographs in research to understand the complex environment experienced by homeless people, with a special interest in mental health. Read More

Biomed Inform Insights 2018 31;10:1178222618807481. Epub 2018 Oct 31.

Department of Computer Science and Engineering, The Ohio State University, Columbus, OH, USA.

Convolutional neural networks (CNNs) have gained steady popularity as a tool to perform automatic classification of whole slide histology images. While CNNs have proven to be powerful classifiers in this context, they fail to explain this classification, as the network engineered features used for modeling and classification are ONLY interpretable by the CNNs themselves. This work aims at enhancing a traditional neural network model to perform histology image modeling, patient classification, and interpretation of the distinctive features identified by the network within the histology whole slide images (WSIs). Read More

Biomed Inform Insights 2018 2;10:1178222618803076. Epub 2018 Oct 2.

Personal Health Informatics, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

Non-adherence with pharmacologic treatment is associated with increased rates of relapse and rehospitalisation among patients with schizophrenia and bipolar disorder. To improve treatment response, remission, and recovery, research efforts are still needed to elucidate how to effectively map patient's response to medication treatment including both therapeutic and adverse effects, compliance, and satisfaction in the prodromal phase of illness (ie, the time period in between direct clinical consultation and relapse). The Actionable Intime Insights (AI) application draws information from Australian Medicare administrative claims records in real time when compliance with treatment does not meet best practice guidelines for managing chronic severe mental illness. Read More

Biomed Inform Insights 2018 27;10:1178222618797076. Epub 2018 Aug 27.

School of Social Work, Columbia University, New York, NY, USA.

As the lives of young people expand further into digital spaces, our understandings of their expressions and language on social media become more consequential for providing individualized and applicable mental health resources. This holds true for young people exposed to high rates of community violence who may also lack access to health resources offline. Social media may provide insights into the impacts of community violence exposure on mental health. Read More

Biomed Inform Insights 2018 27;10:1178222618785131. Epub 2018 Jun 27.

Department of Political and Social Sciences, Research Area Visual and Media Anthropology, Freie Universität, Berlin, Germany.

Technological developments, such as the advent of social networking sites, apps, and tracking 'cookies', enable the generation and collection of unprecedented quantities of rich personal and behavioural data, opening up a vast new resource for mental health research. Despite these non-traditional health-related data already forming a vital foundation of many new research avenues, little analysis has been done focusing on the experiences, motivations, and concerns of the individuals already engaged in data sharing and donation practices. This explorative study aims to investigate the experiences of individuals voluntarily donating their data to mental health research, specifically through the open data initiative OurDataHelps. Read More

Biomed Inform Insights 2018 9;10:1178222618785122. Epub 2018 Jul 9.

London, UK.

Biomed Inform Insights 2018 4;10:1178222618777749. Epub 2018 Jun 4.

Massachusetts General Hospital, Boston, MA, USA.

Informatics for Integrating Biology and the Bedside (i2b2) is an open source clinical data analytics platform used at more than 150 institutions for querying patient data. An i2b2 installation (called hive) comprises several i2b2 cells that provide different functionalities. Given the complex architecture of i2b2 installation, creating a working installation of the platform is challenging for new users. Read More

Biomed Inform Insights 2018 29;10:1178222618777758. Epub 2018 May 29.

Nursing Course of Kochi Medical School, Nankoku, Japan.

We evaluated quasi-healthy cohorts (model cohorts), derived from clinical data, to determine how well they simulated control cohorts. Control cohorts comprised individuals extracted from a public checkup database in Japan, under the condition that their values for 3 basic laboratory tests fall within specific reference ranges (3Ts condition). Model cohorts comprised outpatients, extracted from a clinical database at a hospital, under the 3Ts condition or under the condition that their values for 4 laboratory tests fall within specific reference ranges (4Ts condition). Read More

Biomed Inform Insights 2018 3;10:1178222618763155. Epub 2018 Apr 3.

Computer Science, Columbia University, New York, NY, USA.

There is a dearth of research investigating youths' experience of grief and mourning after the death of close friends or family. Even less research has explored the question of how youth use social media sites to engage in the grieving process. This study employs qualitative analysis and natural language processing to examine tweets that follow 2 deaths. Read More

Biomed Inform Insights 2018 28;10:1178222618764732. Epub 2018 Mar 28.

Department of Psychiatry, University of Cambridge, Cambridge, UK.

The conference aims were two-fold: (1) to explore how digital technology is implemented into personalized and/or group mental health interventions and (2) to promote digital equality through developing culturally sensitive ways of bringing technological innovation to disadvantaged groups. A broad scope of perspectives were welcomed and encouraged, from lived experience, academic, clinical, media, the arts, policy-making, tech innovation, and other perspectives. Read More

Biomed Inform Insights 2017 7;9:1178222617745557. Epub 2017 Dec 7.

DAN Europe Foundation, Ta'Xbiex, Malta.

The use of precordial Doppler monitoring to prevent decompression sickness (DS) is well known by the scientific community as an important instrument for early diagnosis of DS. However, the timely and correct diagnosis of DS without assistance from diving medical specialists is unreliable. Thus, a common protocol for the manual annotation of echo Doppler signals and a tool for their automated recording and annotation are necessary. Read More

Biomed Inform Insights 2017 12;9:1178222617712994. Epub 2017 Jun 12.

Department of Research, Dascena, Inc, Hayward, CA, USA.

Algorithm-based clinical decision support (CDS) systems associate patient-derived health data with outcomes of interest, such as in-hospital mortality. However, the quality of such associations often depends on the availability of site-specific training data. Without sufficient quantities of data, the underlying statistical apparatus cannot differentiate useful patterns from noise and, as a result, may underperform. Read More

Biomed Inform Insights 2017 8;9:1178222617713018. Epub 2017 Jun 8.

Department of Biomedical Informatics, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.

The objective of this study was to determine whether the Food and Drug Administration's Adverse Event Reporting System (FAERS) data set could serve as the basis of automated electronic health record (EHR) monitoring for the adverse drug reaction (ADR) subset of adverse drug events. We retrospectively collected EHR entries for 71 909 pediatric inpatient visits at Cincinnati Children's Hospital Medical Center. Natural language processing (NLP) techniques were used to identify positive diseases/disorders and signs/symptoms (DDSSs) from the patients' clinical narratives. Read More

Biomed Inform Insights 2017 11;9:1178222617700627. Epub 2017 Apr 11.

School of Biomedical Informatics, The University of Texas, Houston, TX, USA.

Personalized and precision vaccination requires consideration of an individual's sex and age. This article proposed systematic methods to study individual differences in adverse reactions following vaccination and chose trivalent influenza vaccine as a use case. Data were extracted from the Vaccine Adverse Event Reporting System from years 1990 to 2014. Read More

Biomed Inform Insights 2017 30;9:1178222617700626. Epub 2017 Mar 30.

Denver Public Health, Denver, CO, USA.

Introduction: Recent pertussis outbreaks in the United States suggest our response to local disease outbreaks (eg, vaccine-preventable ) may benefit from understanding and applying spatial analytical methods that use data from immunization information systems at a subcounty level.

Methods: A 2012 study on Denver, CO, residents less than 19 years of age confirmed pertussis cases and immunization information system records were geocoded and aggregated to the census tract (CT) level. An algorithm assessed whether individuals were up-to-date (UTD) for pertussis vaccines. Read More

Biomed Inform Insights 2017 30;9:1178222617697975. Epub 2017 Mar 30.

Department of Pharmacy Practice, University of Kansas School of Pharmacy, Kansas City, KS, USA.

This systematic review sought to assess the applications and implications of current medical informatics-based decision support systems related to medication prescribing and use. Studies published between January 2006 and July 2016 which were indexed in PubMed and written in English were reviewed, and 39 studies were ultimately included. Most of the studies looked at computerized provider order entry or clinical decision support systems. Read More

Biomed Inform Insights 2017 16;9:1178222617692538. Epub 2017 Feb 16.

Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Pharmacies have been endorsed as alternative vaccine delivery sites to improve vaccination rates through increased access to services. Our objective was to identify challenges and facilitators to adolescent and adult vaccination provision in pharmacy settings in the United States. We recruited 40 licensed pharmacists in states with different pharmacy vaccination laws. Read More

Biomed Inform Insights 2017 9;9:1178222616688893. Epub 2017 Feb 9.

Public Health Informatics Program and Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.

The vision for management of immunization information is availability of real-time consolidated data and services for all ages, to clinical, public health, and other stakeholders. This is being executed through Immunization Information Systems (IISs), which are population-based and confidential computerized systems present in most US states and territories. Immunization Information Systems offer many functionalities, such as immunization assessment reports, client follow-up, reminder/recall feature, vaccine management tools, state-supplied vaccine ordering, comprehensive immunization history, clinical decision support/vaccine forecasting and recommendations, data processing, and data exchange. Read More

Biomed Inform Insights 2017 8;9:1178222616686067. Epub 2017 Feb 8.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Religious or spiritual struggles are clinically important to health care chaplains because they are related to poorer health outcomes, involving both mental and physical health problems. Identifying persons experiencing religious struggle poses a challenge for chaplains. One potentially underappreciated means of triaging chaplaincy effort are prayers written in chapel notebooks. Read More

Biomed Inform Insights 2017 10;9:1178222616685880. Epub 2017 Feb 10.

Centre for Rural Health Studies, Faculty of Medicine, Memorial University of Newfoundland St. John's, NL, Canada.

Objective: To assess the validity of the International Classification of Disease (ICD) codes for identifying patients with dyslipidemia in electronic medical record (EMR) data.

Methods: The EMRs of patients receiving primary care in St. John's, Newfoundland and Labrador (NL), Canada, were retrieved from the Canadian Primary Care Sentinel Surveillance Network database. Read More

Biomed Inform Insights 2016 22;8(Suppl 2):23-29. Epub 2016 Dec 22.

Minnesota Department of Health, St. Paul, MN, USA.

Immunization information systems (IIS) are population-based and confidential computerized systems maintained by public health agencies containing individual data on immunizations from participating health care providers. IIS hold comprehensive vaccination histories given across providers and over time. An important aspect to IIS is the clinical decision support for immunizations (CDSi), consisting of vaccine forecasting algorithms to determine needed immunizations. Read More

Biomed Inform Insights 2016 4;8(Suppl 2):15-21. Epub 2016 Dec 4.

Department of Medicine, Division of Epidemiology, Vanderbilt University Medical School, Nashville, TN, USA.

All preteens should receive tetanus-diphtheria-pertussis vaccine (Tdap), quadrivalent meningococcal vaccine (Men-ACWY), and the human papillomavirus (HPV) cancer vaccine series. In Tennessee, HPV vaccination rates have stagnated at low levels for a decade. Three fundamental strategies to reduce missed opportunities for immunization include administering all recommended vaccines at the same visit, making strong recommendations for vaccines, and auditing and feedback. Read More

Biomed Inform Insights 2016 19;8(Suppl 2):1-13. Epub 2016 Oct 19.

President, HLN Consulting, LLC, Palm Desert, CA, USA.

This article focuses on the requirements and current developments in clinical decision support technologies for immunizations (CDSi) in both the public health and clinical communities, with an emphasis on shareable solutions. The requirements of the Electronic Health Record Incentive Programs have raised some unique challenges for the clinical community, including vocabulary mapping, update of changing guidelines, single immunization schedule, and scalability. This article discusses new, collaborative approaches whose long-term goal is to make CDSi more sustainable for both the public and private sectors. Read More

Biomed Inform Insights 2016 19;8:29-38. Epub 2016 Jul 19.

Professor, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

In natural language processing, stand-off annotation uses the starting and ending positions of an annotation to anchor it to the text and stores the annotation content separately from the text. We address the fundamental problem of efficiently storing stand-off annotations when applying natural language processing on narrative clinical notes in electronic medical records (EMRs) and efficiently retrieving such annotations that satisfy position constraints. Efficient storage and retrieval of stand-off annotations can facilitate tasks such as mapping unstructured text to electronic medical record ontologies. Read More

Biomed Inform Insights 2016 23;8(Suppl 1):13-22. Epub 2016 Jun 23.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

The concept of optimizing health care by understanding and generating knowledge from previous evidence, ie, the Learning Health-care System (LHS), has gained momentum and now has national prominence. Meanwhile, the rapid adoption of electronic health records (EHRs) enables the data collection required to form the basis for facilitating LHS. A prerequisite for using EHR data within the LHS is an infrastructure that enables access to EHR data longitudinally for health-care analytics and real time for knowledge delivery. Read More

Biomed Inform Insights 2016 20;8(Suppl 1):1-11. Epub 2016 Jun 20.

Medical Informatics, Kaiser Permanente Southern California, San Diego, CA, USA.

In an era when most of our life activities are digitized and recorded, opportunities abound to gain insights about population health. Online product reviews present a unique data source that is currently underexplored. Health-related information, although scarce, can be systematically mined in online product reviews. Read More

Biomed Inform Insights 2016 25;8:19-27. Epub 2016 May 25.

School of Business and Economic, Universiti Brunei Darussalam, Brunei Darussalam.

Mobile technology enables health-care organizations to extend health-care services by providing a suitable environment to achieve mobile health (mHealth) goals, making some health-care services accessible anywhere and anytime. Introducing mHealth could change the business processes in delivering services to patients. mHealth could empower patients as it becomes necessary for them to become involved in the health-care processes related to them. Read More

Biomed Inform Insights 2016 22;8:11-8. Epub 2016 May 22.

Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.

Objective: We describe the development and evaluation of a system that uses machine learning and natural language processing techniques to identify potential candidates for surgical intervention for drug-resistant pediatric epilepsy. The data are comprised of free-text clinical notes extracted from the electronic health record (EHR). Both known clinical outcomes from the EHR and manual chart annotations provide gold standards for the patient's status. Read More

Biomed Inform Insights 2016 19;8:1-10. Epub 2016 Jan 19.

College of Health Science, Department of Health Informatics and Administration, Center for Biomedical Data and Language Processing, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.

Big data technologies are increasingly used for biomedical and health-care informatics research. Large amounts of biological and clinical data have been generated and collected at an unprecedented speed and scale. For example, the new generation of sequencing technologies enables the processing of billions of DNA sequence data per day, and the application of electronic health records (EHRs) is documenting large amounts of patient data. Read More

Biomed Inform Insights 2015 1;7:1-9. Epub 2015 Apr 1.

University of Ibadan, Ibadan, Nigeria.

Nowadays, an electronic health information management system (EHIMS) is crucial for patient care in hospitals. This paper explores the aspects and elements that contribute to the success of EHIMS in Nigerian teaching hospitals. The study adopted a survey research design. Read More

Biomed Inform Insights 2013 1;6(Suppl 1):51-62. Epub 2013 Aug 1.

LIMSI-CNRS, Orsay, France.

Medical entity recognition is currently generally performed by data-driven methods based on supervised machine learning. Expert-based systems, where linguistic and domain expertise are directly provided to the system are often combined with data-driven systems. We present here a case study where an existing expert-based medical entity recognition system, Ogmios, is combined with a data-driven system, Caramba, based on a linear-chain Conditional Random Field (CRF) classifier. Read More

Biomed Inform Insights 2013 15;6(Suppl 1):39-50. Epub 2013 Jul 15.

Cognitive Science Research Group, School of Electronic Engineering and Computer Science, London, UK.

Previous research shows that aspects of doctor-patient communication in therapy can predict patient symptoms, satisfaction and future adherence to treatment (a significant problem with conditions such as schizophrenia). However, automatic prediction has so far shown success only when based on low-level lexical features, and it is unclear how well these can generalize to new data, or whether their effectiveness is due to their capturing aspects of style, structure or content. Here, we examine the use of topic as a higher-level measure of content, more likely to generalize and to have more explanatory power. Read More

Biomed Inform Insights 2013 22;6:35-45. Epub 2013 Jul 22.

Department of Pediatrics, Division of Respiratory Medicine, University of California, San Diego, USA. ; Department of Medicine, Division of Biomedical Informatics, University of California, San Diego, USA.

The database of Genotypes and Phenotypes (dbGaP) allows researchers to understand phenotypic contribution to genetic conditions, generate new hypotheses, confirm previous study results, and identify control populations. However, effective use of the database is hindered by suboptimal study retrieval. Our objective is to evaluate text classification techniques to improve study retrieval in the context of the dbGaP database. Read More

Biomed Inform Insights 2013 24;6(Suppl 1):29-37. Epub 2013 Jun 24.

University of Wisconsin-Milwaukee, Milwaukee, WI, USA.

Converting information contained in natural language clinical text into computer-amenable structured representations can automate many clinical applications. As a step towards that goal, we present a method which could help in converting novel clinical phrases into new expressions in SNOMED CT, a standard clinical terminology. Since expressions in SNOMED CT are written in terms of their relations with other SNOMED CT concepts, we formulate the important task of identifying relations between clinical phrases and SNOMED CT concepts. Read More

Biomed Inform Insights 2013 24;6(Suppl 1):17-27. Epub 2013 Jun 24.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

Because of privacy concerns and the expense involved in creating an annotated corpus, the existing small-annotated corpora might not have sufficient examples for learning to statistically extract all the named-entities precisely. In this work, we evaluate what value may lie in automatically generated features based on distributional semantics when using machine-learning named entity recognition (NER). The features we generated and experimented with include n-nearest words, support vector machine (SVM)-regions, and term clustering, all of which are considered distributional semantic features. Read More

Biomed Inform Insights 2013 24;6(Suppl 1):7-16. Epub 2013 Jun 24.

Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.

A large amount of medication information resides in the unstructured text found in electronic medical records, which requires advanced techniques to be properly mined. In clinical notes, medication information follows certain semantic patterns (eg, medication, dosage, frequency, and mode). Some medication descriptions contain additional word(s) between medication attributes. Read More

Biomed Inform Insights 2013 24;6(Suppl 1):3-5. Epub 2013 Jun 24.

Mayo Clinic, Rochester, MN.

Biomed Inform Insights 2013 24;6(Suppl 1):1-2. Epub 2013 Jun 24.

Biomed Inform Insights 2013 25;6:29-33. Epub 2013 Apr 25.

AT&T Interactive, Glendale, CA, USA.

Introduction: Syndromic surveillance is designed for early detection of disease outbreaks. An important data source for syndromic surveillance is free-text chief complaints (CCs), which are generally recorded in the local language. For automated syndromic surveillance, CCs must be classified into predefined syndromic categories. Read More

Biomed Inform Insights 2013 2;6:15-27. Epub 2013 Apr 2.

School of ITEE, University of Queensland, Australia.

Today's search engines and digital libraries offer little or no support for discovering those scientific artifacts (hypotheses, supporting/contradicting statements, or findings) that form the core of scientific written communication. Consequently, we currently have no means of identifying central themes within a domain or to detect gaps between accepted knowledge and newly emerging knowledge as a means for tracking the evolution of hypotheses from incipient phases to maturity or decline. We present a hybrid Machine Learning approach using an ensemble of four classifiers, for recognizing scientific artifacts (ie, hypotheses, background, motivation, objectives, and findings) within biomedical research publications, as a precursory step to the general goal of automatically creating argumentative discourse networks that span across multiple publications. Read More

Biomed Inform Insights 2013 4;6:1-14. Epub 2013 Feb 4.

School of ITEE, The University of Queensland, Australia.

Over the course of the last few years there has been a significant amount of research performed on ontology-based formalization of phenotype descriptions. The intrinsic value and knowledge captured within such descriptions can only be expressed by taking advantage of their inner structure that implicitly combines qualities and anatomical entities. We present a meta-model (the Phenotype Fragment Ontology) and a processing pipeline that enable together the automatic decomposition and conceptualization of phenotype descriptions for the human skeletal phenome. Read More