4,398 results match your criteria Biomedical Engineering-biomedizinische Technik[Journal]


Osteoclast and osteoblast response to strontium-doped struvite coatings on titanium for improved bone integration.

Biomed Tech (Berl) 2020 May 26. Epub 2020 May 26.

Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

To develop implants with improved bone ingrowth, titanium substrates were coated with homogeneous and dense struvite (MgNH4PO4·6H2O) layers by means of electrochemically assisted deposition. Strontium nitrate was added to the coating electrolyte in various concentrations, in order to fabricate Sr-doped struvite coatings with Sr loading ranging from 10.6 to 115 μg/cm2. Read More

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http://dx.doi.org/10.1515/bmt-2019-0265DOI Listing

Electrocardiography (ECG) analysis and a new feature extraction method using wavelet transform with scalogram analysis.

Biomed Tech (Berl) 2020 May 22. Epub 2020 May 22.

Department of Biophysics, Faculty of Medicine, Gaziantep University, Şahinbey, Gaziantep, Turkey.

Electrocardiography (ECG) signals and the information obtained through the analysis of these signals constitute the main source of diagnosis for many cardiovascular system diseases. Therefore, accurate analyses of ECG signals are very important for correct diagnosis. In this study, an ECG analysis toolbox together with a user-friendly graphical user interface, which contains the all ECG analysis steps between the recording unit and the statistical investigation, is developed. Read More

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http://dx.doi.org/10.1515/bmt-2019-0147DOI Listing

Does preconditioning lower the rupture resistance of chorioamniotic membrane?

Biomed Tech (Berl) 2020 May 20. Epub 2020 May 20.

Biomechanics Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.

Premature rupture of fetal membrane occurs in about 3% of all pregnancies. The physical integrity of chorioamnion (CA) membrane should be retained until delivery for a healthy pregnancy. To explore the effect of pre-conditioning and probe size on the mechanical properties of human chorioamniotic sac, the mechanical properties of 17 human chorioamniotic membranes, collected from cesarean delivery, were examined using biaxial puncture tests with and without preconditioning by different probe sizes. Read More

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http://dx.doi.org/10.1515/bmt-2019-0337DOI Listing

Developing a novel resorptive hydroxyapatite-based bone substitute for over-critical size defect reconstruction: physicochemical and biological characterization and proof of concept in segmental rabbit's ulna reconstruction.

Biomed Tech (Berl) 2020 Apr 25. Epub 2020 Apr 25.

Laboratory for Atomic Physics, Institute for Nuclear Sciences Vinca, University of Belgrade, 11000 Belgrade, Serbia.

The aim of this study was to develop novel hydroxyapatite (HAP)-based bioactive bone replacement materials for segmental osteotomy reconstruction. Customized three-dimensional (3D) bone construct was manufactured from nanohydroxyapatite (nHAP) with poly(lactide-co-glycolide) (PLGA) coating using 3D models derived from the computed tomography (CT) scanning of the rabbit's ulna and gradient 3D printing of the bone substitute mimicking the anatomical shape of the natural bone defect. Engineered construct revealed adequate micro-architectural design for successful bone regeneration having a total porosity of 64% and an average pore size of 256 μm. Read More

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http://dx.doi.org/10.1515/bmt-2019-0218DOI Listing
April 2020
2.425 Impact Factor

Titanium coating: introducing an antibacterial and bioactive chitosan-alginate film on titanium by spin coating.

Biomed Tech (Berl) 2020 Apr 24. Epub 2020 Apr 24.

Department of Biomedical Engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran 4515-775, Iran.

Coating of titanium (Ti) implants with biocompatible polymers were performed to improve bone healing. In this study, pure Ti implants were coated via chitosan and alginate by spin coating method at 1000, 4000, and 8000 rpm. The coating layer was cross-linked by calcium chloride. Read More

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http://dx.doi.org/10.1515/bmt-2018-0108DOI Listing

Electrical stimulator with mechanomyography-based real-time monitoring, muscle fatigue detection, and safety shut-off: a pilot study.

Biomed Tech (Berl) 2020 Apr 17. Epub 2020 Apr 17.

Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.

Functional electrical stimulation (FES) has been used to produce force-related activities on the paralyzed muscle among spinal cord injury (SCI) individuals. Early muscle fatigue is an issue in all FES applications. If not properly monitored, overstimulation can occur, which can lead to muscle damage. Read More

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http://dx.doi.org/10.1515/bmt-2019-0191DOI Listing

A nonlinear dynamical approach to analysis of emotions using EEG signals based on the Poincaré map function and recurrence plots.

Biomed Tech (Berl) 2020 Apr 13. Epub 2020 Apr 13.

Department of Radiology, Faculty of Paramedicine, AJA University of Medical Sciences, 1411861919 Tehran, Iran.

Dynamic variations of electroencephalogram (EEG) contain significant information in the study of human emotional states. Transient time methods are well suited to evaluate short-term dynamic changes in brain activity. Human affective states, however, can be more appropriately analyzed using chaotic dynamical techniques, in which temporal variations are considered over longer durations. Read More

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http://dx.doi.org/10.1515/bmt-2019-0121DOI Listing

Matching pursuit algorithm for enhancing EEG signal quality and increasing the accuracy and efficiency of emotion recognition.

Authors:
Ali Momennezhad

Biomed Tech (Berl) 2020 Apr 1. Epub 2020 Apr 1.

Sahand University of Technology, Tabriz-Sahand, 1996-51335 Tabriz, Iran.

In this paper, we suggest an efficient, accurate and user-friendly brain-computer interface (BCI) system for recognizing and distinguishing different emotion states. For this, we used a multimodal dataset entitled "MAHOB-HCI" which can be freely reached through an email request. This research is based on electroencephalogram (EEG) signals carrying emotions and excludes other physiological features, as it finds EEG signals more reliable to extract deep and true emotions compared to other physiological features. Read More

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http://dx.doi.org/10.1515/bmt-2019-0327DOI Listing

Properties of different types of dry electrodes for wearable smart monitoring devices.

Biomed Tech (Berl) 2020 Apr 1. Epub 2020 Apr 1.

Vinča Institute of Nuclear Sciences, Mike Petrovića Alasa 12-14, 11351 Belgrade, Serbia.

Wearable smart monitors (WSMs) applied for the estimation of electrophysiological signals are of utmost interest for a non-stressed life. WSM which records heart muscle activities could signalize timely a life-threatening event. The heart muscle activities are typically recorded across the heart at the surface of the body; hence, a WSM monitor requires high-quality surface electrodes. Read More

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http://dx.doi.org/10.1515/bmt-2019-0167DOI Listing

A Matlab toolbox for analyzing repetitive movements: application in gait and tapping experiments.

Biomed Tech (Berl) 2020 Feb 3. Epub 2020 Feb 3.

Institute of Neuroscience and Medicine - INM-7, Research Centre Jülich, 52425 Jülich, Germany.

Coordination and timing in repetitive movements have been intensively investigated in diverse experimental settings for understanding the underlying basic mechanisms in healthy controls. On this basic research side, there are mainly two theoretical models: the Wing-Kristofferson (WK) model and the Haken-Kelso-Bunz (HKB) model. On the clinical side of the research, several efforts have been spent on quantitatively assessing gait and other repetitive movements such as tapping, especially as an outcome measure of clinical trials in diverse neurological disorders. Read More

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http://dx.doi.org/10.1515/bmt-2018-0189DOI Listing
February 2020

Adolescent age estimation using voice features.

Biomed Tech (Berl) 2020 Jan 14. Epub 2020 Jan 14.

Faculty of Biomedical Engineering, Department of Informatics and Medical Equipment, Silesian University of Technology, Roosevelta 40, 44-800 Zabrze, Poland.

In this paper, a method for evaluating the chronological age of adolescents on the basis of their voice signal is presented. For every examined child, the vowels a, e, i, o and u were recorded in extended phonation. Sixty voice parameters were extracted from each recording. Read More

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http://dx.doi.org/10.1515/bmt-2018-0082DOI Listing
January 2020

Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications.

Biomed Tech (Berl) 2020 Jan 11. Epub 2020 Jan 11.

Manav Rachna International University (MRIU) and Manav Rachna International Institute of Research and Study (MRIIRS), Faridabad, HR 121 001, India.

Pay-load deliveries across the skin barrier to the systemic circulation have been one of the most challenging delivery options. Necessitated requirements of the skin and facilitated skin layer cross-over delivery attempts have resulted in development of different non-invasive, non-oral methods, devices and systems which have been standardized, concurrently used and are in continuous upgrade and improvements. Iontophoresis, electroporation, sonophoresis, magnetophoresis, dermal patches, nanocarriers, needled and needle-less shots, and injectors are among some of the methods of transdermal delivery. Read More

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http://dx.doi.org/10.1515/bmt-2019-0019DOI Listing
January 2020
2.425 Impact Factor

A comprehensive evaluation for the prediction of mortality in intensive care units with LSTM networks: patients with cardiovascular disease.

Biomed Tech (Berl) 2019 Dec 16. Epub 2019 Dec 16.

Soft Computing and Expert System Laboratory, ABV-Indian Institute of Information Technology and Management, Gwalior 474010, Madhya Pradesh, India.

Intensive care units (ICUs) are responsible for generating a wealth of useful data in the form of electronic health records. We aimed to build a mortality prediction model on a Medical Information Mart for Intensive Care (MIMIC-III) database and to assess whether the use of deep learning techniques like long short-term memory (LSTM) can effectively utilize the temporal relations among clinical variables. The models were built on clinical variable dynamics of the first 48 h of ICU admission of 12,550 records from the MIMIC-III database. Read More

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http://dx.doi.org/10.1515/bmt-2018-0206DOI Listing
December 2019

Objectivization of vacuum-compression therapy effects on micro- and macrovascular perfusion in type 2 diabetic patients.

Biomed Tech (Berl) 2019 Dec 13. Epub 2019 Dec 13.

Faculty of Biomedical Engineering, Czech Technical University in Prague, Nám. Sítná 3105, 272 01 Kladno, Czech Republic.

The present study aimed to evaluate the characteristic influence of physical therapeutic procedures of vacuum-compression therapy (VCT) on microvascular perfusion (MiP) and macrovascular perfusion (MaP) of the lower limb in diabetic patients. A sample of nine patients with a medical history of type 2 diabetes was used for the purpose of this study. Most of the subjects' medical conditions included venous and neurological complications of the lower limb, whereas the rest of the subjects entered the treatment due to injury recovery or their phlebological disease. Read More

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http://dx.doi.org/10.1515/bmt-2019-0066DOI Listing
December 2019

Optimisation of the drill-in behaviour of the EcoFit® SC threaded cup.

Biomed Tech (Berl) 2019 Dec 13. Epub 2019 Dec 13.

Department of Orthopaedics, Physical Medicine and Rehabilitation, University Hospital, LMU Munich, Marchioninistr. 15, 81377 Munich, Germany.

Threaded cups show good clinical results when implanted correctly. In clinical use, multiple cases with an incomplete placement of the EcoFit threaded cup (implantcast) were observed. This behaviour could not be explained intra- and postoperatively. Read More

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http://dx.doi.org/10.1515/bmt-2019-0016DOI Listing
December 2019

Dual-frequency bioelectrical phase angle to estimate the platelet count for the prognosis of dengue fever in Indian children.

Biomed Tech (Berl) 2019 Dec 13. Epub 2019 Dec 13.

Department of Electronics and Communication Engineering, Pondicherry Engineering College, Puducherry 605014, India.

A noninvasive investigation to ascertain the platelet (PLT) count was conducted on 44 hospitalized dengue hemorrhagic fever (DHF) subjects, male and female aged between 3 and 14 years using bioelectrical phase angle (BPhA). Among the 44 subjects, 30 subjects were confirmed to be non-structural protein-1 (NS1) positive at the time of admission, whose blood investigations such as hematocrit (HCT) level, PLT count, aspartate aminotransferase (AST) level and alanine aminotransferase (ALT) level were performed for the classification of risk as low-risk (LR) and high-risk (HR) DHF. It was found that the BPhA of the body reflects a linear correlation with the PLT count. Read More

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http://dx.doi.org/10.1515/bmt-2018-0203DOI Listing
December 2019

Evaluation of potential auras in generalized epilepsy from EEG signals using deep convolutional neural networks and time-frequency representation.

Biomed Tech (Berl) 2019 Dec 11. Epub 2019 Dec 11.

Department of Electrical and Electronics Engineering, Dicle University, Diyarbakır, Turkey.

The general uncertainty of epilepsy and its unpredictable seizures often affect badly the quality of life of people exposed to this disease. There are patients who can be considered fortunate in terms of prediction of any seizures. These are patients with epileptic auras. Read More

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http://dx.doi.org/10.1515/bmt-2019-0098DOI Listing
December 2019

Thermography and colour Doppler ultrasound: a potential complementary diagnostic tool in evaluation of rheumatoid arthritis in the knee region.

Biomed Tech (Berl) 2019 Dec 10. Epub 2019 Dec 10.

Department of Biomedical Engineering, Faculty of Engineering and Technology, SRMIST, Kattankulathur, Chennai 603203, Tamil Nadu, India.

The aim and objectives of this study were as follows: (i) to perform automated segmentation of knee thermal image using the regional isotherm-based segmentation (RIBS) algorithm and segmentation of ultrasound image using the image J software; (ii) to implement the RIBS algorithm using computer-aided diagnostic (CAD) tools for classification of rheumatoid arthritis (RA) patients and normal subjects based on feature extraction values; and (iii) to correlate the extracted thermal imaging features and colour Doppler ultrasound (CDUS) features in the knee region with the biochemical parameters in RA patients. Thermal image analysis based on skin temperature measurement and thermal image segmentation was performed using the RIBS algorithm in the knee region of RA patients and controls. There was an increase in the average skin temperature of 5. Read More

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http://dx.doi.org/10.1515/bmt-2019-0051DOI Listing
December 2019

Realisation and assessment of a low-cost LED device for contact lens disinfection by visible violet light.

Biomed Tech (Berl) 2019 Dec 6. Epub 2019 Dec 6.

Ulm University of Applied Sciences, Institute of Medical Engineering and Mechatronics, Albert-Einstein-Allee 55, D-89081 Ulm, Germany.

This study presents a device for efficient, low-cost and eye-friendly overnight disinfection of contact lenses by visible violet light as an alternative to disinfection with biocide-containing solutions. Bacterial solutions with one Pseudomonas and one Staphylococcus strain each were irradiated for up to 8 h in commercial transparent contact lens cases by the presented light-emitting diode (LED) device. Samples were taken at different intervals and distributed on agar plates. Read More

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http://dx.doi.org/10.1515/bmt-2019-0231DOI Listing
December 2019

Wireless power transmission in endoscopy capsules.

Biomed Tech (Berl) 2019 Dec;64(6):677-682

Department of Biomedical Engineering, University of Applied Sciences, 07745 Jena, Germany.

The operating life of endoscopy capsules is limited by the batteries needed for use. The capacity of corresponding batteries, however, is too short to cover the total period of gastrointestinal transit. To overcome this limitation, a novel kind of wireless power transmission was used. Read More

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http://dx.doi.org/10.1515/bmt-2017-0135DOI Listing
December 2019

The effectiveness of the choice of criteria on the stationary and non-stationary noise removal in the phonocardiogram (PCG) signal using discrete wavelet transform.

Biomed Tech (Berl) 2019 Nov 29. Epub 2019 Nov 29.

Department of Exact Science and Informatics, University Zian Achour, Djelfa 17000, Algeria.

The greatest problem with recording heart sounds is parasitic noise effects. A reasonable solution to reduce noise can be carried out by minimization of extraneous noises in the vicinity of the patient during recording, in addition to the methods of signal processing that must be effective in noisy environments. Wavelet transform has become an essential tool for many applications, but its effectiveness is influenced by main parameters. Read More

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http://dx.doi.org/10.1515/bmt-2019-0197DOI Listing
November 2019

Correlational study of the center of pressure measures of postural steadiness on five different standing tasks in overweight adults.

Biomed Tech (Berl) 2019 Nov 23. Epub 2019 Nov 23.

Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, 25/25 Phuttamonthon Rd. 4, Salaya, Phuttamonthon, Nakhon Pathom 73170, Thailand.

This study applied the posturography framework on five static standing tasks from the Berg Balance Scale (BBS). Thirteen participants were recruited and the trajectory data of the center of pressure (CoP) were collected. To analyze the postural performance, two approaches were taken: the scores from the BBS and statistical analysis. Read More

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http://dx.doi.org/10.1515/bmt-2018-0115DOI Listing
November 2019

Monitoring the dynamics of acute radiofrequency ablation lesion formation in thin-walled atria - a simultaneous optical and electrical mapping study.

Biomed Tech (Berl) 2019 Nov 22. Epub 2019 Nov 22.

Karlsruhe Institute of Technology, Institute of Biomedical Engineering, Fritz-Haber-Weg 1, Karlsruhe 76131, Germany.

Background Radiofrequency ablation (RFA) is a common approach to treat cardiac arrhythmias. During this intervention, numerous strategies are applied to indirectly estimate lesion formation. However, the assessment of the spatial extent of these acute injuries needs to be improved in order to create well-defined and durable ablation lesions. Read More

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http://dx.doi.org/10.1515/bmt-2019-0013DOI Listing
November 2019

GPU-enabled design of an adaptable pattern recognition system for discriminating squamous intraepithelial lesions of the cervix.

Biomed Tech (Berl) 2019 Nov 20. Epub 2019 Nov 20.

Department of Medical Physics, School of Health Sciences, Faculty of Medicine, University of Patras, Rio, Patras, Greece.

The aim of the present study was to design an adaptable pattern recognition (PR) system to discriminate low- from high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively) of the cervix using microscopy images of hematoxylin and eosin (H&E)-stained biopsy material from two different medical centers. Clinical material comprised H&E-stained biopsies of 66 patients diagnosed with LSIL (34 cases) or HSIL (32 cases). Regions of interest were selected from each patient's digitized microscopy images. Read More

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http://dx.doi.org/10.1515/bmt-2019-0040DOI Listing
November 2019

Effective segmentation and classification of tumor on liver MRI and CT images using multi-kernel K-means clustering.

Biomed Tech (Berl) 2019 Nov 20. Epub 2019 Nov 20.

Department of Electrical and Instrumentation Engineering, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.

Our proposed research technique intends to provide an effective liver magnetic resonance imaging (MRI) and computed tomography (CT) scan image classification which would play a significant role in medical dataset especially in feature selection and classification. There are a number of existing research works classifying the liver tumor disease. Early detection of liver tumor will help the patients to get cured rapidly. Read More

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http://dx.doi.org/10.1515/bmt-2018-0175DOI Listing
November 2019

Multimodal feature learning and fusion on B-mode ultrasonography and sonoelastography using point-wise gated deep networks for prostate cancer diagnosis.

Biomed Tech (Berl) 2020 Jan;65(1):87-98

Department of Ultrasound in Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China.

B-mode ultrasonography and sonoelastography are used in the clinical diagnosis of prostate cancer (PCa). A combination of the two ultrasound (US) modalities using computer aid may be helpful for improving the diagnostic performance. A technique for computer-aided diagnosis (CAD) of PCa is presented based on multimodal US. Read More

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http://dx.doi.org/10.1515/bmt-2018-0136DOI Listing
January 2020
2.425 Impact Factor

Dynamic cerebral perfusion parameters and magnetic nanoparticle accumulation assessed by AC biosusceptometry.

Biomed Tech (Berl) 2019 Nov 12. Epub 2019 Nov 12.

Department of Physics and Biophysics, UNESP, São Paulo State University, Biosciences Institute of Botucatu, Botucatu, Brazil.

Cerebral blood flow (CBF) assessment is mainly performed by scintigraphy, computed tomography (CT) and magnetic resonance imaging (MRI). New approaches to assess the CBF through the passage of magnetic nanoparticles (MNPs) to blood-brain barrier (BBB) are convenient to help decrease the use of ionizing radiation and unleash the required MRI schedule in clinics. The development of nanomedicine and new biomedical devices, such as the magnetic particle imaging (MPI), enabled new approaches to study dynamic brain blood flow. Read More

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http://dx.doi.org/10.1515/bmt-2019-0089DOI Listing
November 2019

A robust grey wolf-based deep learning for brain tumour detection in MR images.

Authors:
A Geetha N Gomathi

Biomed Tech (Berl) 2020 Apr;65(2):191-207

VelTech Dr. Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Avadi, Chennai 600062, Tamil Nadu, India.

In recent times, the detection of brain tumours has become more common. Generally, a brain tumour is an abnormal mass of tissue where the cells grow uncontrollably and are apparently unregulated by the mechanisms that control cells. A number of techniques have been developed thus far; however, the time needed in a detecting brain tumour is still a challenge in the field of image processing. Read More

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http://dx.doi.org/10.1515/bmt-2018-0244DOI Listing

Diagnosis of attention-deficit hyperactivity disorder using EOG signals: a new approach.

Biomed Tech (Berl) 2020 Apr;65(2):149-164

Erciyes University, Engineering Faculty, Biomedical Engineering Department, 39039 Kayseri, Turkey.

A system based on objective data was developed in the diagnosis and follow-up of attention-deficit hyperactivity disorder (ADHD) in this study. First of all, an electronic circuit, with a two-channel instrumentation amplifier designed to detect eye movements in the horizontal and vertical directions via surface electrodes, was developed to obtain the electrooculogram (EOG) signals. In order to provide a controlled analysis of eye movements during the reception of the signal, an attention test with visual stimulus software was developed. Read More

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http://dx.doi.org/10.1515/bmt-2019-0027DOI Listing

Sonographic visibility of cannulas using convex ultrasound transducers.

Biomed Tech (Berl) 2019 Dec;64(6):691-698

Faculty of Electrical Engineering and Information Technology, Chair of Medical Engineering, Ruhr-University Bochum, 44801 Bochum, Germany.

The key for safe ultrasound (US)-guided punctures is a good visibility of the cannula. When using convex transducers for deep punctures, the incident angle between US beam and cannula varies along the cannula leading to a complex visibility pattern. Here, we present a method to systematically investigate the visibility throughout the US image. Read More

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http://dx.doi.org/10.1515/bmt-2018-0174DOI Listing
December 2019

Mussel-inspired polydopamine-mediated surface modification of freeze-cast poly (ε-caprolactone) scaffolds for bone tissue engineering applications.

Biomed Tech (Berl) 2019 Oct 28. Epub 2019 Oct 28.

Biomaterials Research Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Tehran, Iran.

There are many methods used to fabricate the scaffolds for tissue regeneration, among which freeze casting has attracted a great deal of attention due to the capability to create a unidirectional structure. In this study, polycaprolactone (PCL) scaffolds were fabricated by freeze-casting technology in order to create porous microstructure with oriented open-pore channels. To induce biomineralization, and to improve hydrophilicity and cell interactions, mussel-inspired polydopamine (PDA) was coated on the surface of the freeze-cast PCL constructs. Read More

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http://dx.doi.org/10.1515/bmt-2019-0061DOI Listing
October 2019
4 Reads

Functional and radiographic evaluation of an interspinous device as an adjunct for lumbar interbody fusion procedures.

Biomed Tech (Berl) 2020 Apr;65(2):183-189

Queen Elisabeth University Hospital, Glasgow, Scotland, UK.

In the last decades, several interspinous process devices were designed as a minimally invasive treatment option for spinal stenosis. In order to minimise surgical trauma, interspinous process devices were recently discussed as an alternative posterior fixation in vertebral interbody fusions. Therefore, the purpose of this study was to evaluate the effect of a newly designed interspinous device with polyester bands (PBs) on range of motion (RoM) and centre of rotation (CoR) of a treated motion segment in comparison with an established interspinous device with spikes (SC) as well as with pedicle screw instrumentation in lumbar fusion procedures. Read More

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http://dx.doi.org/10.1515/bmt-2018-0086DOI Listing

Folic acid decorated metal-organic frameworks loaded with doxorubicin for tumor-targeted chemotherapy of osteosarcoma.

Biomed Tech (Berl) 2020 Apr;65(2):229-236

Department of Orthopaedics, Eastern Hepatobiliary Surgery Hospital, Naval Military Medical University, 201800 Shanghai, China.

Effective cancer therapy usually requires the assistance of well-designed drug carriers. In order to increase the drug accumulation to tumor tissue as well as to reduce the side effects of drug carriers, the hybrid drug delivery system (DDS) was developed by integrating folic acid (FA) and a metal-organic framework (MOF). The anticancer drug doxorubicin (DOX) was preloaded into the MOF nanoparticles during the synthesis process of the MOF nanoparticles. Read More

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http://dx.doi.org/10.1515/bmt-2019-0056DOI Listing
April 2020
1 Read

Computer-aided classification of small airways dysfunction using impulse oscillometric features: a children-focused review.

Biomed Tech (Berl) 2020 Apr;65(2):121-131

Departamento de Fisiología Respiratoria, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Col. Sección XVI, Alcaldía Tlalpan, Ciudad de México 14080, Mexico.

Background and objective Spirometry, which is the most commonly used technique for asthma diagnosis, is often unsuitable for small children as it requires them to follow exact instructions and perform extreme inspiration and expiration maneuvers. In contrast, impulse oscillometry (IOS) is a child-friendly technique that could serve as an alternative pulmonary function test (PFT) for asthma diagnosis and control in children as it offers several advantages over spirometry. However, the complex test results of IOS may be difficult to be understood by practitioners due to its reliance on mechanical and electrical models of the human pulmonary system. Read More

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http://dx.doi.org/10.1515/bmt-2018-0219DOI Listing
April 2020
1 Read

Mechanomyography-based assessment during repetitive sit-to-stand and stand-to-sit in two incomplete spinal cord-injured individuals.

Biomed Tech (Berl) 2020 Apr;65(2):175-181

Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Standing up and sitting down movements are important prerequisites to achieve functional independence in everyday life of spinal cord injury (SCI) patients. Thus, mechanomyography (MMG) was proposed as a safe monitoring tool to evaluate muscle function performance of these activities. Two incomplete SCI participants performed repetitive sit-to-stand (SitTS) and stand-to-sit (StandTS) until fatigued challenge. Read More

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http://dx.doi.org/10.1515/bmt-2018-0200DOI Listing
April 2020
1 Read

Effective brain connectivity estimation between active brain regions in autism using the dual Kalman-based method.

Biomed Tech (Berl) 2020 Jan;65(1):23-32

Neurorehabilitation and Neuropsychological Services, Massapequa Park, NY 11762, USA.

Brain connectivity estimation is a useful method to study brain functions and diagnose neuroscience disorders. Effective connectivity is a subdivision of brain connectivity which discusses the causal relationship between different parts of the brain. In this study, a dual Kalman-based method is used for effective connectivity estimation. Read More

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http://dx.doi.org/10.1515/bmt-2019-0062DOI Listing
January 2020
1 Read

Quadriceps mechanomyography reflects muscle fatigue during electrical stimulus-sustained standing in adults with spinal cord injury - a proof of concept.

Biomed Tech (Berl) 2020 Apr;65(2):165-174

Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.

This study investigates whether mechanomyography (MMG) produced from contracting muscles as a measure of their performance could be a proxy of muscle fatigue during a sustained functional electrical stimulation (FES)-supported standing-to-failure task. Bilateral FES-evoked contractions of quadriceps and glutei muscles, of four adults with motor-complete spinal cord injury (SCI), were used to maintain upright stance using two different FES frequencies: high frequency (HF - 35 Hz) and low frequency (LF - 20 Hz). The time at 30° knee angle reduction was taken as the point of critical "fatigue failure", while the generated MMG characteristics were used to track the pattern of force development during stance. Read More

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http://dx.doi.org/10.1515/bmt-2019-0118DOI Listing
April 2020
2 Reads

Epileptic seizure recognition using EEG wavelet decomposition based on nonlinear and statistical features with support vector machine classification.

Biomed Tech (Berl) 2020 Apr;65(2):133-148

Biomedical Engineering Laboratory, Faculty of Technology, Abou Bekr Belkaid University, Tlemcen 13048, Algeria.

Epileptic seizure (ES) is a neurological brain dysfunction. ES can be detected using the electroencephalogram (EEG) signal. However, visual inspection of ES using long-time EEG recordings is a difficult, time-consuming and a costly procedure. Read More

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http://dx.doi.org/10.1515/bmt-2018-0246DOI Listing

A left ventricular phantom for 3D echocardiographic twist measurements.

Biomed Tech (Berl) 2020 Apr;65(2):209-218

Department of Clinical Science, University of Bergen, Haukeland University Hospital, 5021 Bergen, Norway.

Traditional two-dimensional (2D) ultrasound speckle tracking echocardiography (STE) studies have shown a wide range of twist values, also for normal hearts, which is due to the limitations of short-axis 2D ultrasound. The same limitations do not apply to three-dimensional (3D) ultrasound, and several studies have shown 3D ultrasound to be superior to 2D ultrasound, which is unreliable for measuring twist. The aim of this study was to develop a left ventricular twisting phantom and to evaluate the accuracy of 3D STE twist measurements using different acquisition methods and volume rates (VR). Read More

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http://dx.doi.org/10.1515/bmt-2019-0096DOI Listing

Research on elastic recoil and restoration of vessel pulsatility of Zn-Cu biodegradable coronary stents.

Biomed Tech (Berl) 2020 Apr;65(2):219-227

Department of Interventional and Vascular Surgery, The Tenth People's Hospital of Shanghai, Tongji University, Shanghai 200072, P.R. China.

Coronary stents made of zinc (Zn)-0.8 copper (Cu) (in wt%) alloy were developed as biodegradable metal stents (Zn-Cu stents) in this study. The mechanical properties of the Zn-Cu stents and the possible gain effects were characterized by in vitro and in vivo experiments compared with 316L stainless steel stents (316L stents). Read More

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http://dx.doi.org/10.1515/bmt-2019-0025DOI Listing
April 2020
1 Read

Measuring lower limb circumference and volume - introduction of a novel optical 3D volumetric measurement system.

Biomed Tech (Berl) 2020 Apr;65(2):237-241

Department of Orthopaedics, University Medicine Rostock, Doberaner Strasse 142, D-18057 Rostock, Germany.

This study comprised two experiments: (1) the reliability of a novel optical three-dimensional (3D) volumetric measurement system (BODYTRONIC® 600) for the assessment of lower limb circumference and volume; (2) the comparison of data obtained from BODYTRONIC® 600 with that provided by computed tomography (CT) for accuracy estimation. Reliability was assessed in 20 healthy subjects. Accuracy was determined by comparing the deviations in the surface topology of two 3D models obtained from BODYTRONIC® 600 and CT. Read More

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http://dx.doi.org/10.1515/bmt-2018-0100DOI Listing

Automatic hypernasality grade assessment in cleft palate speech based on the spectral envelope method.

Biomed Tech (Berl) 2020 Jan;65(1):73-86

College of Electrical Engineering, Sichuan University, Chengdu 610065, China.

Due to velopharyngeal incompetence, airflow overflows from the oral cavity to the nasal cavity, which results in hypernasality. Hypernasality greatly reduces speech intelligibility and affects the daily communication of patients with cleft palate. Accurate assessment of hypernasality grades can provide assisted diagnosis for speech-language pathologists (SLPs) in clinical settings. Read More

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http://dx.doi.org/10.1515/bmt-2018-0181DOI Listing
January 2020
2 Reads

Automatic analysis of image quality by ETR-1 for the On-Board Imager.

Biomed Tech (Berl) 2020 Jan;65(1):99-105

Faculty of Electrical, Mechanical and Industrial Engineering, Anhalt University of Applied Sciences, D-06366 Köthen, Germany.

The test-plate image of an image quality test tool is processed. The processing is based on quality assurance with the well-established test device ETR-1. A program is developed to analyze the parameters such as contrast, low contrast and resolution automatically. Read More

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http://dx.doi.org/10.1515/bmt-2018-0092DOI Listing
January 2020

Epileptic seizure detection on EEG signals using machine learning techniques and advanced preprocessing methods.

Biomed Tech (Berl) 2020 Jan;65(1):33-50

LETI-ENIS, University of Sfax, Street of Soukra, 3038 Sfax, Tunisia.

Electroencephalography (EEG) is a common tool used for the detection of epileptic seizures. However, the visual analysis of long-term EEG recordings is characterized by its subjectivity, time-consuming procedure and its erroneous detection. Various epileptic seizure detection algorithms have been proposed to deal with such issues. Read More

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http://dx.doi.org/10.1515/bmt-2019-0001DOI Listing
January 2020

Experimental investigation on the effect of drill quality on the performance of bone drilling.

Biomed Tech (Berl) 2020 Jan;65(1):113-120

Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leicestershire, UK.

Bone drilling is a well-known process in operative fracture treatment and reconstructive surgery. The cutting ability of the drill is lost when used for multiple times. In this study, the effect of different levels of drill wear on bone temperature, drilling force, torque, delamination around the drilling region and surface roughness of the hole was investigated using a series of experiments. Read More

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http://dx.doi.org/10.1515/bmt-2018-0184DOI Listing
January 2020
2.425 Impact Factor

EOG-based eye movement recognition using GWO-NN optimization.

Biomed Tech (Berl) 2020 Jan;65(1):11-22

Department of Biomedical Engieering, University College of Engineering, Osmania University, Osmania University Main Rd, Amberpet, Hyderabad, Telangana 500007, India.

In recent times, the control of human-computer interface (HCI) systems is triggered by electrooculography (EOG) signals. Eye movements recognized based on the EOG signal pattern are utilized to govern the HCI system and do a specific job based on the type of eye movement. With the knowledge of various related examinations, this paper intends a novel model for eye movement recognition based on EOG signals by utilizing Grey Wolf Optimization (GWO) with neural network (NN). Read More

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http://dx.doi.org/10.1515/bmt-2018-0109DOI Listing
January 2020

A novel approach to the diagnostic assessment of carpal tunnel syndrome based on the frequency domain of the compound muscle action potential.

Biomed Tech (Berl) 2020 Jan;65(1):61-71

Department of Biomedical Engineering, Faculty of Engineering, İnönü University, Malatya 44280, Turkey.

Conventional electrophysiological (EP) tests may yield ambiguous or false-negative results in some patients with signs and symptoms of carpal tunnel syndrome (CTS). Therefore, researchers tend to investigate new parameters to improve the sensitivity and specificity of EP tests. We aimed to investigate the mean and maximum power of the compound muscle action potential (CMAP) as a novel diagnostic parameter, by evaluating diagnosis and classification performance using the supervised Kohonen self-organizing map (SOM) network models. Read More

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http://dx.doi.org/10.1515/bmt-2018-0077DOI Listing
January 2020
1 Read

Pattern recognition of head movement based on mechanomyography and its application.

Biomed Tech (Berl) 2020 Jan;65(1):51-60

School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China.

The first part of this study investigated pattern recognition of head movements based on mechanomyography (MMG) signals. Four channel MMG signals were collected from the sternocleidomastoid (SCM) muscles and the splenius capitis (SPL) muscles in the subjects' neck when they bowed the head, raised the head, side-bent to left, side-bent to right, turned to left and turned to right. The MMG signals were then filtered, normalized and divided using an unequal length segmentation algorithm into a single action frame. Read More

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http://dx.doi.org/10.1515/bmt-2018-0007DOI Listing
January 2020
2 Reads
2.425 Impact Factor

An improved method to isolate primary human osteocytes from bone.

Biomed Tech (Berl) 2020 Jan;65(1):107-111

Centre for Translational Bone, Joint and Soft Tissue Research, Technische Universität und Universitätsklinikum Dresden, Fetscherstr. 74, Dresden, Germany.

Osteocytes are of high importance in bone metabolism as they orchestrate bone remodeling, react to mechanosensory stimuli and have endocrine functions. In vitro investigations with osteocytes are therefore of high relevance for biomaterial and drug testing. The application of primary human cells instead of rodent osteocyte cell lines like MLOY4 and IDG SW3 is desirable but provides the challenge of isolating these cells, which are deeply embedded into the mineralized bone matrix. Read More

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http://dx.doi.org/10.1515/bmt-2018-0185DOI Listing
January 2020

Radioguided surgery: physical principles and an update on technological developments.

Biomed Tech (Berl) 2020 Jan;65(1):1-10

Chair for Catheter Technologies and Image Guided Procedures, Otto-von-Guericke University, Magdeburg, Germany.

Radioguided surgery (RGS) is the use of radiation detection probes and handheld gamma cameras in surgery rooms to identify radioactively labeled lesions inside the body with an aim to improve surgical outcome. In today's surgery, application of these devices is a well-established practice, which provides surgeons with real-time information to guide them to the site of a lesion. In recent years, there have been several major improvements in the technology and design of gamma probes and handheld gamma cameras, enhancing their applications in surgical practices. Read More

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http://dx.doi.org/10.1515/bmt-2018-0016DOI Listing
January 2020