25,054 results match your criteria Biomedica : revista del Instituto Nacional de Salud[Journal]


Predicting mortality after autologous transplant: Development of a novel risk score.

Biol Blood Marrow Transplant 2020 Jul 5. Epub 2020 Jul 5.

Hematology Transplant Unit, Hospital Universitario Austral, Derqui, Argentina.

There have been several efforts to predict mortality after autologous stem cell transplantation (ASCT), such as the Hematopoietic Cell Transplant-Comorbidity Index (HCT-CI), described for allogeneic-SCT and validated for ASCT, however there is no composite score in the setting of ASCT combining comorbidities with other clinical characteristics. Our aim is to describe a comprehensive score combining comorbidities with other clinical factors and to analyze the impact of this score on non-relapse mortality (NRM), overall survival (OS) and early morbidity end-points (mechanical ventilation, shock or dialysis) after ASCT. For the training cohort, we retrospectively reviewed data of 2068 adult patients who received an ASCT in Argentina (10/2002-06/2017) for multiple myeloma or lymphoma. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.06.028DOI Listing

First molecular characterization of the hepatitis E virus in humans in Cameroon: Confirmation of the HEV outbreak in Touboro, North-Cameroon.

J Med Virol 2020 Jul 8. Epub 2020 Jul 8.

Department of Virology, Centre Pasteur of Cameroon, Yaoundé, Cameroon.

Hepatitis E virus (HEV) is a major causative agent of acute viral hepatitis in many regions of the world including Africa. In Cameroon, there is no published molecular study on HEV in humans. However, based on serological assays, the first outbreak of HEV was detected in North-Cameroon. Read More

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http://dx.doi.org/10.1002/jmv.26277DOI Listing

Late Coronary Stent Thrombosis in a Patient With Coronavirus Disease 2019.

JAMA Cardiol 2020 Jul 8. Epub 2020 Jul 8.

Hospital Universitario de La Princesa, Madrid, Spain.

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http://dx.doi.org/10.1001/jamacardio.2020.2459DOI Listing

Levosimendan Efficacy and Safety: 20 Years of SIMDAX in Clinical Use.

J Cardiovasc Pharmacol 2020 Jul;76(1):4-22

Critical Care Proprietary Products, Orion Pharma, Espoo, Finland.

Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitization and promotes vasodilatation through the opening of adenosine triphosphate-dependent potassium channels on vascular smooth muscle cells, has been approved in more than 60 jurisdictions, including most of the countries of the European Union and Latin America. Areas of clinical application have expanded considerably and now include cardiogenic shock, takotsubo cardiomyopathy, advanced HF, right ventricular failure, pulmonary hypertension, cardiac surgery, critical care, and emergency medicine. Read More

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http://dx.doi.org/10.1097/FJC.0000000000000859DOI Listing

Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use.

J Cardiovasc Pharmacol 2020 Jun 22. Epub 2020 Jun 22.

Critical Care Proprietary Products, Orion Pharma, Espoo, Finland.

Levosimendan was first approved for clinic use in 2000, when authorisation was granted by Swedish regulatory authorities for the haemodynamic stabilisation of patients with acutely decompensated chronic heart failure. In the ensuing 20 years, this distinctive inodilator, which enhances cardiac contractility through calcium sensitisation and promotes vasodilatation through the opening of adenosine triphosphate-dependent potassium channels on vascular smooth muscle cells, has been approved in more than 60 jurisdictions, including most of the countries of the European Union and Latin America. Areas of clinical application have expanded considerably and now include cardiogenic shock, takotsubo cardiomyopathy, advanced heart failure, right ventricular failure and pulmonary hypertension, cardiac surgery, critical care and emergency medicine. Read More

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http://dx.doi.org/10.1097/FJC.0000000000000859DOI Listing

COSAN-stabilised omega-3 oil-in-water nanoemulsions to prolong lung residence time for poorly water soluble drugs.

Chem Commun (Camb) 2020 Jul 8. Epub 2020 Jul 8.

Radiochemistry and nuclear Imaging Group, CIC biomaGUNE, 20014 San Sebastian, Guipuzcoa, Spain. and Centro de Investigación Biomédica en Red, Enfermedades Respiratorias - CIBERES, Spain.

Herein, we report on the capacity of the amphiphilic inorganic anion cobalt bis(dicarbollide) to stabilise oil-in-water nanoemulsions (NEs). The resulting NEs show long term stability in water and high drug-loading capacity, and can prolong the residence time of hydrophobic drugs in the lungs as determined by in vivo positron emission tomography imaging. Read More

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http://dx.doi.org/10.1039/d0cc00918kDOI Listing

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.

Aging Cell 2020 Jul 7:e13183. Epub 2020 Jul 7.

Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Leioa, Spain.

Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence has been associated with age-dependent hepatosteatosis. Thus, we investigated the role of OPN in the age-related hepatosteatosis. Read More

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http://dx.doi.org/10.1111/acel.13183DOI Listing

Energy sensors in drug addiction: A potential therapeutic target.

Addict Biol 2020 Jul 7:e12936. Epub 2020 Jul 7.

Instituto de Investigación Biomédica de Málaga (IBIMA), UGC Salud Mental, Hospital Regional Universitario de Málaga, Málaga, Spain.

Addiction is defined as the repeated exposure and compulsive seek of psychotropic drugs that, despite the harmful effects, generate relapse after the abstinence period. The psychophysiological processes associated with drug addiction (acquisition/expression, withdrawal, and relapse) imply important alterations in neurotransmission and changes in presynaptic and postsynaptic plasticity and cellular structure (neuroadaptations) in neurons of the reward circuits (dopaminergic neuronal activity) and other corticolimbic regions. These neuroadaptation mechanisms imply important changes in neuronal energy balance and protein synthesis machinery. Read More

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http://dx.doi.org/10.1111/adb.12936DOI Listing

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis.

Apoptosis 2020 Jul 7. Epub 2020 Jul 7.

Department of Dermatology and Allergology, School of Medicine, Technical University of Munich, Biedersteinerstr. 29, 80802, München, Germany.

Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such as neuroprotection or induction of apoptosis and eryptosis. However, the effects of costunolide on pro-survival factors and enzymes in human erythrocytes, e.g. Read More

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http://dx.doi.org/10.1007/s10495-020-01620-6DOI Listing

Non-coding RNAs - Update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.

Cardiovasc Res 2020 Jul 8. Epub 2020 Jul 8.

Institute for Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.

Vast parts of mammalian genomes are actively transcribed, predominantely giving rise to non-coding RNA transcripts including microRNAs, long non-coding RNA and circular RNAs amongst others. Contrary to previous opinions that most of these RNA are non-functional molecules, they are now recognised as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional non-coding RNAs has opened up new research avenues aiming at understanding non-coding RNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. Read More

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http://dx.doi.org/10.1093/cvr/cvaa195DOI Listing

Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome.

Mol Ther Methods Clin Dev 2020 Sep 11;18:280-290. Epub 2020 Jun 11.

Epithelial Biomedicine Division, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), 28040 Madrid, Spain.

Current efforts to find specific genodermatoses treatments and define precise pathogenesis mechanisms require appropriate surrogate models with human cells. Although transgenic and gene knockout mouse models for several of these disorders exist, they often fail to faithfully replicate the clinical and histopathological features of the human skin condition. We have established a highly efficient method for precise deletion of critical gene sequences in primary human keratinocytes, based on CRISPR-Cas9-mediated gene editing. Read More

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http://dx.doi.org/10.1016/j.omtm.2020.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329935PMC
September 2020

A Humanized Diet Profile May Facilitate Colonization and Immune Stimulation in Human Microbiota-Colonized Mice.

Front Microbiol 2020 19;11:1336. Epub 2020 Jun 19.

Section of Experimental Animal Models, Department of Veterinary Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: In spite of the importance of the use of gnotobiotic mice for human fecal transfer, colonization efficiency and immune stimulation after human microbiota inoculation in mice are poorly studied compared to mouse microbiota inoculation. We tested the colonization efficiency and immune responses in mice bred for one additional generation after inoculating the parent generation with either a human (HM) or a mouse microbiota (MM). Furthermore, we tested if colonization efficiency and immune stimulation could be improved in HM-colonized mice by dietary approaches: if these were fed a diet closer to the human diet either in its sources of animal fat and protein [the "animal source" (AS) diet] or in its proportions of macronutrients from the normal sources of a mouse diet [the "human profile" (HP) diet]. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318556PMC

IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms.

Nat Commun 2020 Jul 7;11(1):3390. Epub 2020 Jul 7.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Immunoglobulin (Ig) gene rearrangements and oncogenic translocations are routinely assessed during the characterization of B cell neoplasms and stratification of patients with distinct clinical and biological features, with the assessment done using Sanger sequencing, targeted next-generation sequencing, or fluorescence in situ hybridization (FISH). Currently, a complete Ig characterization cannot be extracted from whole-genome sequencing (WGS) data due to the inherent complexity of the Ig loci. Here, we introduce IgCaller, an algorithm designed to fully characterize Ig gene rearrangements and oncogenic translocations from short-read WGS data. Read More

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http://dx.doi.org/10.1038/s41467-020-17095-7DOI Listing

Gender-Affirming Hormone Therapy Modifies the CpG Methylation Pattern of the ESR1 Gene Promoter After Six Months of Treatment in Transmen.

J Sex Med 2020 Jul 4. Epub 2020 Jul 4.

Departamento de Psicología, Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da Coruña (UDC), Campus de Elviña, A Coruña, Spain; Instituto de Investigación Biomédica de A Coruña (INIBIC), CHUAC, SERGAS, A Coruña, Spain.

Background: Brain sexual differentiation is a process that results from the effects of sex steroids on the developing brain. Evidence shows that epigenetics plays a main role in the formation of enduring brain sex differences and that the estrogen receptor α (ESR1) is one of the implicated genes.

Aim: To analyze whether the methylation of region III (RIII) of the ESR1 promoter is involved in the biological basis of gender dysphoria. Read More

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http://dx.doi.org/10.1016/j.jsxm.2020.05.027DOI Listing

Socioeconomically Disadvantaged Groups and Metabolic Syndrome in European Adolescents: The HELENA Study.

J Adolesc Health 2020 Jul 4. Epub 2020 Jul 4.

GENUD (Growth, Exercise, NUtrition and Development) Research Group, Faculty of Health Sciences, Deparment of Physiatry and Nursing, University of Zaragoza, Zaragoza, Spain; Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain.

Purpose: Psychosocial stressors derived from socioeconomic disadvantages in adolescents can result in higher risk of metabolic syndrome (MetS). We aimed to examine whether socioeconomic disadvantages were associated with MetS independent of lifestyle and whether there was a dose-response relationship between the number of cumulated socioeconomic disadvantages and risk of MetS.

Methods: This study included 1,037 European adolescents (aged 12. Read More

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http://dx.doi.org/10.1016/j.jadohealth.2020.05.027DOI Listing

Left ventricle myocardial deformation pattern in severe aortic valve stenosis without cardiac amyloidosis. The AMY-TAVI trial.

Rev Esp Cardiol (Engl Ed) 2020 Jul 4. Epub 2020 Jul 4.

Servicio de Cardiología, Hospital Clínico Universitario de Santiago, Santiago de Compostela, A Coruña, Spain; Instituto para el Desarrollo e Integración de la Salud (IDIS), Santiago de Compostela, A Coruña, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBER-CV), Santiago de Compostela, A Coruña, Spain.

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http://dx.doi.org/10.1016/j.rec.2020.04.024DOI Listing

Hypertension and changes in cognitive function in a Mediterranean population.

Nutr Neurosci 2020 Jul 7:1-9. Epub 2020 Jul 7.

Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.

Severe cognitive decline is one of the major public health problems in developed countries. Finding modifiable risk factors could become essential to develop strategies to prevent or delay dementia progression and stop its rising incidence. Our aim was to investigate the association between hypertension and cognitive function and to assess whether better adherence to the Mediterranean diet may modify this association. Read More

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http://dx.doi.org/10.1080/1028415X.2020.1788773DOI Listing

Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals.

Cancers (Basel) 2020 Jul 5;12(7). Epub 2020 Jul 5.

Hereditary Cancer Program, Catalan Institute of Oncology, Insititut d'Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program. Avinguda de la Gran Via de l'Hospitalet 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.

The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive (epi)genetic analysis. One hundred and fifteen LLS patients harboring MMR-deficient tumors and no germline MMR mutations were included. Read More

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http://dx.doi.org/10.3390/cancers12071799DOI Listing

Integrated Genomic Analysis of Chromosomal Alterations and Mutations in B-Cell Acute Lymphoblastic Leukemia Reveals Distinct Genetic Profiles at Relapse.

Diagnostics (Basel) 2020 Jul 4;10(7). Epub 2020 Jul 4.

IBSAL, IBMCC, Universidad de Salamanca-CSIC, Cancer Research Center, Campus Miguel de Unamuno, 37007 Salamanca, Spain.

The clonal basis of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is complex and not fully understood. Next-generation sequencing (NGS), array comparative genomic hybridization (aCGH), and multiplex ligation-dependent probe amplification (MLPA) were carried out in matched diagnosis-relapse samples from 13 BCP-ALL patients to identify patterns of genetic evolution that could account for the phenotypic changes associated with disease relapse. The integrative genomic analysis of aCGH, MLPA and NGS revealed that 100% of the BCP-ALL patients showed at least one genetic alteration at diagnosis and relapse. Read More

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http://dx.doi.org/10.3390/diagnostics10070455DOI Listing

Prognostic Significance of the Pluripotency Factors NANOG, SOX2, and OCT4 in Head and Neck Squamous Cell Carcinomas.

Cancers (Basel) 2020 Jul 4;12(7). Epub 2020 Jul 4.

Department of Otolaryngology, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.

Cancer stem cells (CSCs) play major roles in tumor initiation, progression, and resistance to cancer therapy. Several CSC markers have been studied in head and neck squamous cell carcinomas (HNSCC), including the pluripotency factors NANOG, SOX2, and OCT4; however, their clinical significance is still unclear. NANOG, SOX2, and OCT4 expression was evaluated by immunochemistry in 348 surgically-treated HNSCC, and correlated with clinicopathological parameters and patient outcomes. Read More

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http://dx.doi.org/10.3390/cancers12071794DOI Listing

Immunohistochemistry-Based Taxonomical Classification of Bladder Cancer Predicts Response to Neoadjuvant Chemotherapy.

Cancers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain.

Background: Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, patients with basal/squamous (BASQ)-like tumors present with more advanced disease and have worse prognosis. Transcriptomics-defined tumor subtypes are associated with response to NAC. Read More

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http://dx.doi.org/10.3390/cancers12071784DOI Listing

AMP-Chitosan Coating with Bactericidal Activity in the Presence of Human Plasma Proteins.

Molecules 2020 Jul 3;25(13). Epub 2020 Jul 3.

i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal.

Antibiotic resistance is increasing and new strategies are needed to fight infection. Advanced materials are promising tools that can be combined with innovative alternatives to conventional antibiotics to allow more targeted and efficient treatment. In this work, we explored the activity against () of the α-helical antimicrobial peptide (AMP) MSI-78(4-20) (KFLKKAKKFGKAFVKIL) when covalently bound to a chitosan coating. Read More

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http://dx.doi.org/10.3390/molecules25133046DOI Listing

Hepatitis C Virus Influences HIV-1 Viral Splicing in Coinfected Patients.

J Clin Med 2020 Jul 3;9(7). Epub 2020 Jul 3.

Laboratory of Reference and Research on Viral Hepatitis, National Center of Microbiology, Institute of Health Carlos III, 28220 Majadahonda, Madrid, Spain.

Coinfection with hepatitis C virus (HCV) influences HIV reservoir size. However, it is unknown whether this coinfection also induces a higher provirus transcription. Viral transcription is promoted by synergy between cellular factors such as NF-κB and the viral regulator Tat. Read More

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http://dx.doi.org/10.3390/jcm9072091DOI Listing

Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour.

Prog Neuropsychopharmacol Biol Psychiatry 2020 Jul 4:110030. Epub 2020 Jul 4.

Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain; Instituto de Biomedicina de Sevilla-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.

Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal of extra cells during early developmental stages. Hence, an impairment of this process may thus constitute a basis for numerous neurological and psychiatric diseases. This view is especially relevant for dopamine due to its pleiotropic roles in motor control, motivation and reward processing. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.110030DOI Listing

Octreotide-related exocrine pancreatic insufficiency (EPI) in congenital hyperinsulinism.

J Pediatr Endocrinol Metab 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain.

Background Congenital hyperinsulinism (CH) is the most frequent cause of persistent hypoglycemia in the newborn. Octreotide, a long-acting somatostatin receptor analog (SSRA), is a second line treatment for diazoxide unresponsive CH patients. Although it has been found to be a safe and effective treatment, long-term benefits and side effects, have not been thoroughly evaluated. Read More

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http://dx.doi.org/10.1515/jpem-2019-0565DOI Listing

Differential biomarker profiles between unprovoked venous thromboembolism and cancer.

Ann Med 2020 Jul 7:1-26. Epub 2020 Jul 7.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville, Spain.

Background: The relationship between cancer and venous thromboembolic disease (VTD) are complex because the activated coagulation factors are not only involved in thrombosis, but also in malignant processes, such as angiogenesis and metastasis.

Objective: To compare phenotypes of extracellular vesicles (EVs), and levels of D-dimer, soluble P-selectin (sP-selectin) and antigenic tissue factor (TF) between unprovoked VTD patients, who did not develop cancer during one year follow-up, and those with advanced stage of cancer but not associated with VTD.

Methods: A prospective study in which we included 138 unprovoked VTD patients and 67 advanced cancer patients, who did not develop thrombosis. Read More

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http://dx.doi.org/10.1080/07853890.2020.1779956DOI Listing

Prevalence and prognostic impact of subclinical pulmonary congestion at discharge in patients with acute heart failure.

ESC Heart Fail 2020 Jul 7. Epub 2020 Jul 7.

Cardiology Department, Hospital de la Santa Creu i Sant Pau, IIb-SantPau, CIBERCV, Universitat Autónoma de Barcelona, Barcelona, Spain.

Aims: Residual pulmonary congestion at hospital discharge can worsen the outcomes in patients with heart failure (HF) and can be detected by lung ultrasound (LUS). The aim of this study was to analyse the prevalence of subclinical pulmonary congestion at discharge and its impact on prognosis in patients admitted for acute HF.

Methods And Results: This is a post-hoc analysis of the LUS-HF trial. Read More

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http://dx.doi.org/10.1002/ehf2.12842DOI Listing

Crosstalk between circulating microRNAs and chronotypical features in subjects with metabolic syndrome.

Chronobiol Int 2020 Jul 7:1-11. Epub 2020 Jul 7.

Department of Nutrition, Food Science and Physiology; Center for Nutrition Research, University of Navarra , Pamplona, Spain.

Circulating microRNAs (miRNAs) are valuable biomarkers that may provide important insight into the pathogenesis of metabolic syndrome (MetS). Moreover, there is an association between chronotypical characteristics and MetS predisposition. Considering that expression of some miRNAs is circadian-rhythm-dependent, the aim of this study was to investigate the circulating miRNA profile in subjects with and without MetS in association with chronotype. Read More

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http://dx.doi.org/10.1080/07420528.2020.1782419DOI Listing

A data-driven polynomial approach to reproduce the scar tissue outgrowth around neural implants.

J Mater Sci Mater Med 2020 Jul 6;31(7):59. Epub 2020 Jul 6.

Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autónoma de Barcellona, and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain.

Despite the huge complexity of the foreign body reaction, a quantitative assessment over time of the scar tissue thickness around implanted materials is needed to figure out the evolution of neural implants for long times. A data-driven approach, based on phenomenological polynomial functions, is able to reproduce experimental data. Nevertheless, a misuse of this strategy may lead to unsatisfactory results, even if standard indexes are optimized. Read More

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http://dx.doi.org/10.1007/s10856-020-06396-4DOI Listing

Rib cage anatomy in Homo erectus suggests a recent evolutionary origin of modern human body shape.

Nat Ecol Evol 2020 Jul 6. Epub 2020 Jul 6.

Centre for Human Evolution Research, Department of Earth Sciences, The Natural History Museum, London, UK.

The tall and narrow body shape of anatomically modern humans (Homo sapiens) evolved via changes in the thorax, pelvis and limbs. It is debated, however, whether these modifications first evolved together in African Homo erectus, or whether H. erectus had a more primitive body shape that was distinct from both the more ape-like Australopithecus species and H. Read More

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http://dx.doi.org/10.1038/s41559-020-1240-4DOI Listing

TRAF3 Modulation: Novel Mechanism for the Anti-inflammatory Effects of the Vitamin D Receptor Agonist Paricalcitol in Renal Disease.

J Am Soc Nephrol 2020 Jul 6. Epub 2020 Jul 6.

Molecular and Cellular Biology in Renal and Vascular Pathology, Fundación Instituto de Investigación Sanitaria-Fundación Jiménez Díaz,Universidad autonoma de madrid, Madrid, Spain

Background: CKD leads to vitamin D deficiency. Treatment with vitamin D receptor agonists (VDRAs) may have nephroprotective and anti-inflammatory actions, but their mechanisms of action are poorly understood.

Methods: Modulation of the noncanonical NF-B2 pathway and its component TNF receptor-associated factor 3 (TRAF3) by the VDRA paricalcitol was studied in PBMCs from patients with ESKD, cytokine-stimulated cells, and preclinical kidney injury models. Read More

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http://dx.doi.org/10.1681/ASN.2019111206DOI Listing

Tendencies in cause of death in patients with chronic heart failure and depressed systolic function.

Rev Esp Cardiol (Engl Ed) 2020 Jul 3. Epub 2020 Jul 3.

Unidad de Insuficiencia Cardiaca, Servicio de Cardiología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain; Instituto de Salud Carlos III, CIBERCV, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.rec.2020.03.027DOI Listing

Seed Heads of Dandelion Flowers in Histological Sections.

Int J Surg Pathol 2020 Jul 7:1066896920939660. Epub 2020 Jul 7.

Centro de Investigación Biomédica y Aplicada (CIBAP), Unidad de Histología, Escuela de Medicina, Universidad de Santiago de Chile, Santiago, Chile.

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http://dx.doi.org/10.1177/1066896920939660DOI Listing

A Novel Approach for the Identification of Pharmacogenetic Variants in through Next-Generation Sequencing Off-Target Data.

J Clin Med 2020 Jul 2;9(7). Epub 2020 Jul 2.

Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

Specific genetic variants in the mitochondrially encoded 12S ribosomal RNA gene () cause aminoglycoside-induced irreversible hearing loss. Mitochondrial DNA is usually not included in targeted sequencing experiments; however, off-target data may deliver this information. Here, we extract genetic variation, including the most relevant ototoxicity variant m. Read More

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http://dx.doi.org/10.3390/jcm9072082DOI Listing

Reactive Species in Huntington Disease: Are They Really the Radicals You Want to Catch?

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Laboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.

Huntington disease (HD) is a neurodegenerative condition and one of the so-called rare or minority diseases, due to its low prevalence (affecting 1-10 of every 100,000 people in western countries). The causative gene, , encodes huntingtin, a protein with a yet unknown function. Mutant huntingtin causes a range of phenotypes, including oxidative stress and the activation of microglia and astrocytes, which leads to chronic inflammation of the brain. Read More

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http://dx.doi.org/10.3390/antiox9070577DOI Listing

Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance.

Cells 2020 Jun 25;9(6). Epub 2020 Jun 25.

Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Sepsis is a life-threatening condition that occurs when the body responds to an infection that damages it is own tissues. The major problem in sepsis is rapid, vital status deterioration in patients, which can progress to septic shock with multiple organ failure if not properly treated. As there are no specific treatments, early diagnosis is mandatory to reduce high mortality. Read More

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http://dx.doi.org/10.3390/cells9061544DOI Listing

Functional and Mass Spectrometric Evaluation of an Anti-Tick Antigen Based on the P0 Peptide Conjugated to Bm86 Protein.

Pathogens 2020 Jun 25;9(6). Epub 2020 Jun 25.

Animal Biotechnology Department, Center for Genetic Engineering and Biotechnology (CIGB), Havana 10600, Cuba.

A synthetic 20 amino acid peptide of the ribosomal protein P0 from ticks, when conjugated to keyhole limpet hemocyanin from and used as an immunogen against and s.l. species, has shown efficacies of around 90%. Read More

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http://dx.doi.org/10.3390/pathogens9060513DOI Listing

Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer.

Cancers (Basel) 2020 Jul 1;12(7). Epub 2020 Jul 1.

Maimónides Biomedical Research Institute of Córdoba (IMIBIC), E14004 Córdoba, Spain.

Liquid biopsy may assist in the management of cancer patients, which can be particularly applicable in pancreatic ductal adenocarcinoma (PDAC). In this study, we investigated the utility of circulating cell-free DNA (cfDNA)-based markers as prognostic tools in metastatic PDAC. Plasma was obtained from 61 metastatic PDAC patients, and cfDNA levels and fragmentation were determined. Read More

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http://dx.doi.org/10.3390/cancers12071754DOI Listing

Global Gene Expression Characterization of Circulating Tumor Cells in Metastasic Castration-Resistant Prostate Cancer Patients.

J Clin Med 2020 Jul 1;9(7). Epub 2020 Jul 1.

Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain.

Background: Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tumors, including PC, often do not have recent tumor tissue available for analysis. The biomarker characterization in CTCs could provide insights into the current state of the disease and an overall picture of the intra-tumor heterogeneity. Read More

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http://dx.doi.org/10.3390/jcm9072066DOI Listing

Epigenetic Regulation of Gfi1 in Endocrine-Related Cancers: a Role Regulating Tumor Growth.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Departamento de Biología de Sistemas, Unidad Docente de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares, 28054 Madrid, Spain.

Prostate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcriptional repressor with an important role in human malignancies, including leukemia, colorectal carcinoma, and lung cancer, but its role in prostate and breast cancer is unknown. Read More

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http://dx.doi.org/10.3390/ijms21134687DOI Listing

Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish.

Molecules 2020 Jun 30;25(13). Epub 2020 Jun 30.

Laboratorio de Síntesis Orgánica y Farmacología Molecular, Departamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, Temuco 4811230, Chile.

Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex behaviours that makes it useful for assessing the effects of psychoactive drugs. Here, adult zebrafish were used for assessment of the anxiolytic and anti-addictive properties of UFR2709, a nicotinic receptor (nAChR) antagonist, using two behavioural paradigms to test for addiction, the novel tank diving test to assess anxiety and the conditioned place preference (CPP). Read More

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http://dx.doi.org/10.3390/molecules25132998DOI Listing

Effectiveness of a primary care clinical ultrasound classroom for family physicians as a formative intervention system, a quasi-experimental trial: Study protocol.

Medicine (Baltimore) 2020 Jul;99(27):e19914

Instituto de Investigación Biomédica de Salamanca (IBSAL), Unidad de Investigación de Atención Primaria de Salamanca (APISAL).

Introduction: Clinical ultrasound is a technique that increases diagnostic capacity and facilitates clinical decision making. The objective is to develop and validate an ultrasound training methodology oriented to the clinical practice of the family physician.

Methods: Quasi-experimental study, with a before/after design, a control group, and 1 year of follow-up. Read More

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http://dx.doi.org/10.1097/MD.0000000000019914DOI Listing

Production of anti-inflammatory compounds in cell suspension cultivated in stirred tank bioreactor.

Eng Life Sci 2019 Mar 2;19(3):196-205. Epub 2019 Jan 2.

Centro de Desarrollo de Productos Bióticos (CEPROBI) Instituto Politécnico Nacional (IPN) Yautepec Morelos Mexico.

is a plant used for the treatment of inflammatory processes. Scopoletin, tomentin, and sphaeralcic acid were identified as the compounds with anti-inflammatory and immunomodulatory effects. Successful establishment of the cell culture in Erlenmeyer flasks has been reported previously. Read More

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http://dx.doi.org/10.1002/elsc.201800134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999246PMC

Ceftazidime-avibactam in the Treatment of Infections Caused by KPC-producing K. pneumoniae: factors associated with clinical efficacy in a single-center cohort.

Int J Antimicrob Agents 2020 Jul 3:106075. Epub 2020 Jul 3.

Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Infectious Diseases Unit. Hospital Universitario Reina Sofía, Universidad de Cordoba, Cordoba, Spain.

Background: Infections caused by KPC-producing K. pneumoniae (KPC-Kp) are not well represented in pivotal trials with ceftazidime-avibactam (CAZ-AVI). Our aim was to investigate its efficacy in a single-centre cohort of patients infected with KPC-Kp. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106075DOI Listing

In-vitro effect of diazoxon, a metabolite of diazinon, on proliferation, signal transduction, and death induction in mononuclear cells of Nile tilapia fish (Oreochromis niloticus).

Fish Shellfish Immunol 2020 Jul 3. Epub 2020 Jul 3.

Laboratorio de Inmunotoxicología, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit, Cd de la Cultura s/n, Z.P. 63000, Tepic Nayarit, Mexico; Laboratorio Nacional de Investigación para la Inocuidad Alimentaria (LANIIA)-Unidad Nayarit, Centro Nayarita de Innovación y Transferencia de Tecnología A.C., Calle Tres s/n. Col. Cd Industrial, Z.P. 63173, Tepic, Mexico. Electronic address:

The immune response of teleosts (bonefish) is altered by diazinon (DZN), an organophosphate pesticide. It has been suggested that such alteration is due to the extraneuronal cholinergic system in fish leukocytes that renders these cells a target of pesticides. Diazoxon (DZO), the oxon metabolite of DZN, has been attributed immunotoxic effects. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.07.001DOI Listing

Potential neurological effects of severe COVID-19 infection.

Neurosci Res 2020 Jul 3. Epub 2020 Jul 3.

Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica, Palermo, Italy. Electronic address:

Coronaviruses (CoVs) are large positive stranded enveloped RNA viruses that generally cause enteric and respiratory diseases in humans and in animals. Most human CoVs have recently attracted global attention to their lethal potential and great infectious capacity. A highly pathogenic CoV, called COVID-19 or SARS-CoV2, dramatically emerged in December 2019 in Wuhan, China. Read More

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http://dx.doi.org/10.1016/j.neures.2020.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333632PMC

Surgery for Crohn's disease during pregnancy: a difficult decision.

United European Gastroenterol J 2020 Jul;8(6):633-634

Inflammatory Bowel Disease Unit of Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.

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http://dx.doi.org/10.1177/2050640620928181DOI Listing

Flipped classroom improves results in pathophysiology learning: results of a nonrandomized controlled study.

Adv Physiol Educ 2020 Sep;44(3):370-375

Department of Internal Medicine, Clínica Universidad de Navarra, Pamplona, Spain.

The flipped classroom has become increasingly popular in health professions education. The aim of this study was to analyze its effect on learning in a pathophysiology course. Flipped classroom was introduced to teach respiratory pathophysiology in 2018. Read More

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http://dx.doi.org/10.1152/advan.00153.2019DOI Listing
September 2020