19,901 results match your criteria Biomedica : revista del Instituto Nacional de Salud[Journal]


Upregulation of E93 Gene Expression Acts as the Trigger for Metamorphosis Independently of the Threshold Size in the Beetle Tribolium castaneum.

Cell Rep 2019 Apr;27(4):1039-1049.e2

Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain. Electronic address:

Body size in holometabolous insects is determined by the size at which the juvenile larva undergoes metamorphosis to the pupal stage. To undergo larva-pupa transition, larva must reach a critical developmental checkpoint, the threshold size (TS); however, the molecular mechanisms through which the TS cues this transition remain to be fully characterized. Here, we use the flour beetle Tribolium castaneum to characterize the molecular mechanisms underlying entry into metamorphosis. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.094DOI Listing
April 2019
2 Reads

Psychotic-like experiences and cannabis use in adolescents from the general population.

Adicciones 2019 Mar 28;0(0):1149. Epub 2019 Mar 28.

Universidad de La Rioja Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo.

The purpose of this study was to analyze the relationship between psychotic-like experiences and cannabis use in a representative sample of adolescents from the general population. A total of 1,588 students (M=16.13 years, SD = 1. Read More

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http://dx.doi.org/10.20882/adicciones.1149DOI Listing

Evolution of alcohol and tobacco consumption in young people in Spain, after the law 42/2010 against smoking: 2011-2014.

Adicciones 2019 Mar 28;0(0):1035. Epub 2019 Mar 28.

Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Universidad de Córdoba. Hospital Universitario Reina Sofía de Córdoba. Universidad Pontificia de Salamanca.

The objective of the study was to evaluate alcohol and tobacco consumption in young people in Spain, after Law 42/2010, during the interval of 2011-2014. The sample consisted of 3270 young people aged between 15 and 24 years who completed the National Survey of Health in Spain (ENSE) of 2011 and the European Survey of Health in Spain (EESE) of 2014. Variables: consumption, type of tobacco, attempts to quit smoking, consumption and type of alcoholic beverage, binge drinking, and sociodemographic variables. Read More

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http://dx.doi.org/10.20882/adicciones.1035DOI Listing

The alliance between nerve fibers and stem cell populations in bone marrow: life partners in sickness and health.

FASEB J 2019 Apr 24:fj201900454R. Epub 2019 Apr 24.

Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.

The bone marrow (BM) is the central hematopoietic organ in adult mammals, with great potential to be used as a tool to improve the efficacy of the body's response to a number of malignancies and stressful conditions. The nervous system emerges as a critical regulatory player of the BM both under homeostatic and pathologic settings, with essential roles in cellular anchorage and egress, stem cell differentiation, and endothelial cell permeability. This review collects the current knowledge on the interplay between the nervous system and the BM cell populations, with a focus on how the nervous system modulates hematopoietic stem and progenitor cell, mesenchymal stromal cell, and endothelial progenitor cell activity in BM. Read More

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http://dx.doi.org/10.1096/fj.201900454RDOI Listing

The Response to Stimulation in Neurons and Astrocytes.

Neurochem Res 2019 Apr 23. Epub 2019 Apr 23.

Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Nicolás Cabrera, 1, 28049, Madrid, Spain.

The brain uses mainly glucose as fuel with an index of glucose to oxygen utilization close to 6, the maximal index if all glucose was completely oxidized. However, this high oxidative index, contrasts with the metabolic traits of the major cell types in the brain studied in culture, neurons and astrocytes, including the selective use of the malate-aspartate shuttle (MAS) in neurons and the glycerol-phosphate shuttle in astrocytes. Metabolic interactions among these cell types may partly explain the high oxidative index of the brain. Read More

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http://dx.doi.org/10.1007/s11064-019-02803-7DOI Listing

Targeting P2X4 and P2X7 receptors in multiple sclerosis.

Curr Opin Pharmacol 2019 Apr 20;47:119-125. Epub 2019 Apr 20.

Department of Neurosciences, University of the Basque Country, Achucarro Basque Center for Neuroscience-UPV/EHU, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 48940 Leioa, Spain. Electronic address:

Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by massive infiltration of immune cells, demyelination, and axonal loss. However, spontaneous myelin repair can occur during the course of the disease. A major component of this regenerative process is a robust innate immune response consisting of infiltrating macrophages and brain microgliosis. Read More

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http://dx.doi.org/10.1016/j.coph.2019.03.010DOI Listing

Nose-to-brain delivery of levetiracetam after intranasal administration to mice.

Int J Pharm 2019 Apr 20. Epub 2019 Apr 20.

Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal. Electronic address:

Despite being one of the most commonly prescribed antiepileptic drugs, levetiracetam is marketed in oral and intravenous dosage forms, which are associated to drug-drug interactions and drug-resistant epilepsy (DRE). The purpose of the present study was to assess the potential of the intranasal route to deliver levetiracetam into the brain, due to the particular anatomical features of the nasal cavity. After development and characterization of the drug formulation, a thermoreversible gel loaded with levetiracetam was administered to CD-1 male mice by intranasal route and its pharmacokinetics compared to those observed after intravenous administration. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.047DOI Listing

Treat the dislipemia, something more than giving statines.

Authors:
Luis Masana

Clin Investig Arterioscler 2019 Apr 20. Epub 2019 Apr 20.

Unitat de Medicina Vascular i Metabolisme, Hospital Universitari Sant Joan, Universitat Rovira i Virgili, Institut d'Investigació Sanitària Pere Virgili (IISPV), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Reus, Tarragona, España. Electronic address:

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http://dx.doi.org/10.1016/j.arteri.2019.03.003DOI Listing

Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer.

Crit Rev Oncol Hematol 2019 May 3;137:57-83. Epub 2019 Mar 3.

Laboratorio de HLA, Departamento de Inmunogenética y Alergia, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Mexico City, Mexico.

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the settlement of a metastatic niche in a second organ. Their role in cancer progression is related to their involvement in the extracellular matrix (ECM) degradation and in the regulation and processing of adhesion and cytoskeletal proteins, growth factors, chemokines and cytokines. MMPs participation in cancer progression makes them an attractive target for cancer therapy. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.02.010DOI Listing

Comprehensive kinome NGS targeted expression profiling by KING-REX.

BMC Genomics 2019 Apr 23;20(1):307. Epub 2019 Apr 23.

NMS Oncology, Nerviano Medical Sciences Srl, Nerviano, MI, Italy.

Background: Protein kinases are enzymes controlling different cellular functions. Genetic alterations often result in kinase dysregulation, making kinases a very attractive class of druggable targets in several human diseases. Existing approved drugs still target a very limited portion of the human 'kinome', demanding a broader functional knowledge of individual and co-expressed kinase patterns in physiologic and pathologic settings. Read More

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http://dx.doi.org/10.1186/s12864-019-5676-3DOI Listing

CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA.

J Headache Pain 2019 Apr 23;20(1):39. Epub 2019 Apr 23.

Headache Unit, Neurology Department, Hospital Clínico Universitario de Valladolid, Avda. Ramón y Cajal 3, 47005, Valladolid, Spain.

Background: Some variables have been proposed as predictors of efficacy of OnabotulinumtoxinA in chronic migraine patients, but data available are inconclusive. We aimed to analyse the influence of single nucleotide polymorphisms in the response to OnabotulinumtoxinA.

Methods: We included 156 female patients treated with OnabotulinumtoxinA accordingly to PREEMPT paradigm in three headache units. Read More

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http://dx.doi.org/10.1186/s10194-019-0989-9DOI Listing

Neuroimaging Studies on Disorders of Consciousness: A Meta-Analytic Evaluation.

J Clin Med 2019 Apr 16;8(4). Epub 2019 Apr 16.

NeuroMi, Milan Center for Neuroscience, 20126 Milano, Italy.

Neuroimaging tools could open a window on residual neurofunctional activity in the absence of detectable behavioural responses in patients with disorders of consciousness (DOC). Nevertheless, the literature on this topic is characterised by a large heterogeneity of paradigms and methodological approaches that can undermine the reproducibility of the results. To explicitly test whether task-related functional magnetic resonance imaging (fMRI) can be used to systematically detect neurofunctional differences between different classes of DOC, and whether these differences are related with a specific category of cognitive tasks (either active or passive), we meta-analyzed 22 neuroimaging studies published between 2005 and 2017 using the Activation Likelihood Estimate method. Read More

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http://dx.doi.org/10.3390/jcm8040516DOI Listing

Sequestration of 9-Hydroxystearic Acid in FAHFA (Fatty Acid Esters of Hydroxy Fatty Acids) as a Protective Mechanism for Colon Carcinoma Cells to Avoid Apoptotic Cell Death.

Cancers (Basel) 2019 Apr 12;11(4). Epub 2019 Apr 12.

Instituto de Biología y Genética Molecular, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Valladolid, 47003 Valladolid, Spain.

Hydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through mechanisms involving different targets. Using mass spectrometry-based lipidomic approaches, we show in this study that 9-HSA levels in human colorectal tumors are diminished when compared with normal adjacent tissue. Read More

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http://dx.doi.org/10.3390/cancers11040524DOI Listing

Letter by Romaguera et al Regarding Article, "Newer Generation Ultrathin Strut Drug-Eluting Stents Versus Older Second-Generation Thicker Strut Drug-Eluting Stents for Coronary Artery Disease: Meta-Analysis of Randomized Trials".

Circulation 2019 Apr;139(17):2081-2082

Heart Diseases Institute, Hospital de Bellvitge - IDIBELL (Institut d'Investigació Biomédica de Bellvitge), University of Barcelona, Spain.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038410DOI Listing

High-fat diet promotes adrenaline production by visceral adipocytes.

Eur J Nutr 2019 Apr 22. Epub 2019 Apr 22.

Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine, University of Porto, Alameda Prof Hernâni Monteiro, 4200-319, Porto, Portugal.

Purpose: Catecholamines (CA) play a major role in metabolism and immune response. Recent reports showing adipose tissue can synthetize CA enlighten new roles for these amines in obesity. This study aimed to evaluate the expression of both tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) and CA content along preadipocytes differentiation, under normal and obesigenic conditions. Read More

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http://link.springer.com/10.1007/s00394-019-01971-0
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http://dx.doi.org/10.1007/s00394-019-01971-0DOI Listing
April 2019
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Familial association of genetic generalised epilepsy with limb-girdle muscular dystrophy through a mutation in .

Epilepsy Behav Case Rep 2019 21;11:122-124. Epub 2019 Mar 21.

Hospital Clínico Universitario Lozano Blesa, Avda. San Juan Bosco 15, 50009 Zaragoza, Spain.

•We present a family that includes members with phenotypes of generalized epilepsy and limb-girdle muscular dystrophy.•Subjects with heterozygous mutation developed epilepsy; a subject with homozygous mutation developed limb-girdle dystrophy.•Mutations in CAPN3 may play a role in the complex genetics of genetic generalized epilepsies. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460322PMC

Skipping breakfast is associated with adiposity markers especially when sleep time is adequate in adolescents.

Sci Rep 2019 Apr 23;9(1):6380. Epub 2019 Apr 23.

GENUD (Growth, Exercise, NUtrition and Development) Research Group, Facultad de Ciencias de la Salud de la Universidad de Zaragoza,, Instituto Agroalimentário de Aragón (IA2), Zaragoza, Spain.

Adolescence is a critical stage of development and has an important influence on energy balance-related behaviours (EBRBs). When adolescents are associated with obesity it can lead to increased cardiometabolic risk. Here we assess if EBRBs adopted by adolescents included in a subsample are associated with markers of total and abdominal adiposity in a multicentre European study, Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA-CSS) and a Brazilian study, Brazilian Cardiovascular Adolescent Health (BRACAH study), and whether sleep duration influence the association between skipping breakfast, physical activity and sedentary behaviours, with total and abdominal obesity (AO). Read More

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http://dx.doi.org/10.1038/s41598-019-42859-7DOI Listing

Emotional distress, brain functioning, and biobehavioral processes in cancer patients: a neuroimaging review and future directions.

CNS Spectr 2019 Apr 23:1-22. Epub 2019 Apr 23.

Psycho-oncology, Champalimaud Clinical and Research Center,Champalimaud Foundation,Lisbon,Portugal.

Despite emerging evidence that distress and adversity can contribute to negative health outcomes in cancer, little is known about the brain networks, regions, or circuits that can contribute to individual differences in affect/distress states and health outcomes in treated cancer patients. To understand the state-of-the-science in this regard, we reviewed neuroimaging studies with cancer patients that examined the associations between negative affect (distress) and changes in the metabolism or structure of brain regions. Cancer patients showed changes in function and/or structure of key brain regions such as the prefrontal cortex, thalamus, amygdala, hippocampus, cingulate cortex (mainly subgenual area), hypothalamus, basal ganglia (striatum and caudate), and insula, which are associated with greater anxiety, depression, posttraumatic stress disorder (PTSD) symptoms, and distress. Read More

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http://dx.doi.org/10.1017/S1092852918001621DOI Listing

Cross-hybridization between HPV genotypes in the Linear Array Genotyping Test confirmed by Next-Generation Sequencing.

Diagn Pathol 2019 Apr 22;14(1):31. Epub 2019 Apr 22.

División de Inmunología, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Sierra Mojada No. 800, Col. Independencia, 44340, Guadalajara, Jalisco, Mexico.

Background: Linear Array Genotyping Test (LA) is one of the gold standards used for Human Papillomavirus (HPV) genotyping, however, since its launching in 2006, new HPV genotypes are still being characterized with the use of high specificity techniques such as Next-Generation Sequencing (NGS). Derived from a previous study of the IMSS Research Network on HPV, which suggested that there might be cross-reaction of some HPV genotypes in the LA test, the aim of this study was to elucidate this point.

Methods: Double stranded L1 fragments (gBlocks) from different HPVs were used to perform LA test, additionally, 14 HPV83+ and 26 HPV84+ cervical samples determined with LA, were individually genotyped by NGS. Read More

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http://dx.doi.org/10.1186/s13000-019-0808-2DOI Listing

First Evidence of Antibodies Against Lloviu Virus in Schreiber's Bent-Winged Insectivorous Bats Demonstrate a Wide Circulation of the Virus in Spain.

Viruses 2019 Apr 19;11(4). Epub 2019 Apr 19.

Arbovirus and Imported Viral Diseases Laboratory, National Centre of Microbiology, Majadahonda, 28220 Madrid, Spain.

Although Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber's Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear. We examined the seroprevalence of LLOV in potentially exposed Schreiber's Bent-winged bats ( = 60), common serotine bats ( = 10) as controls, and humans ( = 22) using an immunoblot assay. We found antibodies against LLOV GP in all of Schreiber's Bent-winged bats serum pools, but not in any of the common serotine bats and human pools tested. Read More

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http://dx.doi.org/10.3390/v11040360DOI Listing

Metastatic Niches and the Modulatory Contribution of Mesenchymal Stem Cells and Its Exosomes.

Int J Mol Sci 2019 Apr 20;20(8). Epub 2019 Apr 20.

Remodelative Processes and Cellular Niches Laboratory, Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)-CONICET-Instituto Universitario del Hospital Italiano-Hospital Italiano Buenos Aires (HIBA), C1199ACL Buenos Aires, Argentina.

Mesenchymal stem cells (MSCs) represent an interesting population due to their capacity to release a variety of cytokines, chemokines, and growth factors, and due to their motile nature and homing ability. MSCs can be isolated from different sources, like adipose tissue or bone marrow, and have the capacity to differentiate, both in vivo and in vitro, into adipocytes, chondrocytes, and osteoblasts, making them even more interesting in the regenerative medicine field. Tumor associated stroma has been recognized as a key element in tumor progression, necessary for the biological success of the tumor, and MSCs represent a functionally fundamental part of this associated stroma. Read More

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http://dx.doi.org/10.3390/ijms20081946DOI Listing

From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis.

Nutrients 2019 Apr 20;11(4). Epub 2019 Apr 20.

Neurosciences Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico.

There is an important relationship between probiotics, psychobiotics and cognitive and behavioral processes, which include neurological, metabolic, hormonal and immunological signaling pathways; the alteration in these systems may cause alterations in behavior (mood) and cognitive level (learning and memory). Psychobiotics have been considered key elements in affective disorders and the immune system, in addition to their effect encompassing the regulation of neuroimmune regulation and control axes (the hypothalamic-pituitary-adrenal axis or HPA, the sympathetic-adrenal-medullary axis or SAM and the inflammatory reflex) in diseases of the nervous system. The aim of this review is to summarize the recent findings about psychobiotics, the brain-gut axis and the immune system. Read More

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https://www.mdpi.com/2072-6643/11/4/890
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http://dx.doi.org/10.3390/nu11040890DOI Listing
April 2019
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Location of intracerebral haemorrhage predicts haematoma expansion.

Eur Stroke J 2017 Sep 15;2(3):257-263. Epub 2017 Jun 15.

Department of Medicine (Neurology), Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada.

Introduction: The role of intracerebral haemorrhage location in haematoma expansion remains unclear. Our objective was to assess the effect of lobar versus non-lobar haemorrhage on haematoma expansion and clinical outcome.

Patients And Methods: We analysed data from the prospective PREDICT study where patients with intracerebral haemorrhage presenting to hospital under 6 h of symptom onset received baseline computed tomography (CT), CT angiogram, 24 h follow-up CT, and 90-day mRS. Read More

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http://dx.doi.org/10.1177/2396987317715836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454825PMC
September 2017

The impact of post-stroke complications on in-hospital mortality depends on stroke severity.

Eur Stroke J 2017 Mar 28;2(1):54-63. Epub 2016 Nov 28.

Neurovascular Research Laboratory, Institut de Recerca, Hospital Universitari Vall d'Hebron-Universitat Autónoma de Barcelona, Spain.

Introduction: Controversies remain on whether post-stroke complications represent an independent predictor of poor outcome or just a reflection of stroke severity. We aimed to identify which post-stroke complications have the highest impact on in-hospital mortality by using machine learning techniques. Secondary aim was identification of patient's subgroups in which complications have the highest impact. Read More

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http://dx.doi.org/10.1177/2396987316681872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453178PMC

The influence of childhood obesity on spatio-temporal gait parameters.

Gait Posture 2019 Mar 30;71:69-73. Epub 2019 Mar 30.

Podiatry Department, Health Sciences Faculty, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Malaga, Spain. Electronic address:

The musculoskeletal and neurosensorial development of children can be affected by excess body weight. Studies have examined how childhood obesity affects gait, but much about the influence of this factor remains to be determined. The aim of our study is to analyse, in a large sample of children, the influence of obesity on the spatiotemporal parameters of the gait cycle, in the most natural way possible, with the subjects walking overground at a self-selected speed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183191
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http://dx.doi.org/10.1016/j.gaitpost.2019.03.031DOI Listing
March 2019
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Novel Circulating miRNA Signatures for Early Detection of Pancreatic Neoplasia.

Clin Transl Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Gastrointestinal & Pancreatic Oncology Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)/Hospital Clínic of Barcelona/Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.

Objectives: Pancreatic ductal adenocarcinoma (PDAC) presents the lowest survival rate of all cancers because only 6% of patients reach five-year survival. Alterations in the expression of several microRNAs (miRNAs) occur in the tumor of PDAC and in preneoplastic lesions as the called intraductal papillary mucinous neoplasm (IPMN). Here, we aimed at identifying which miRNAs are significantly altered in liquid biopsies from patients with PDAC and IPMN to find new noninvasive biomarkers for early detection of PDAC. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000029DOI Listing

Sociodemographic factors associated with secondhand smoke exposure and smoking rules in homes with children.

Eur J Public Health 2019 Apr 22. Epub 2019 Apr 22.

Agència de Salut Pública de Barcelona, Servei d'Avaluació i Mètodes d'Intervenció, Barcelona, Spain.

Background: This study aims to identify sociodemographic characteristics associated with secondhand smoke (SHS) exposure and the adoption of smoking bans in homes with children in Spain.

Methods: We performed, in 2016, a cross-sectional study to a representative sample of Spanish households with children under 12 years old. We administered a telephone survey to the parents asking about smoking patterns at home, children's SHS exposure and sociodemographic characteristics. Read More

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https://academic.oup.com/eurpub/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/eurpub/ckz054DOI Listing
April 2019
1 Read

Versatile Graphene-Based Platform for Robust Nanobiohybrid Interfaces.

ACS Omega 2019 Feb;4(2):3287-3297

Materials Science Factory, Institute of Materials Science of Madrid (ICMM-CSIC), Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain.

Technologically useful and robust graphene-based interfaces for devices require the introduction of highly selective, stable, and covalently bonded functionalities on the graphene surface, whilst essentially retaining the electronic properties of the pristine layer. This work demonstrates that highly controlled, ultrahigh vacuum covalent chemical functionalization of graphene sheets with a thiol-terminated molecule provides a robust and tunable platform for the development of hybrid nanostructures in different environments. We employ this facile strategy to covalently couple two representative systems of broad interest: metal nanoparticles, via S-metal bonds, and thiol-modified DNA aptamers, via disulfide bridges. Read More

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http://dx.doi.org/10.1021/acsomega.8b03152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469579PMC
February 2019
1 Read

Epigenetic Influences in the Obesity/Colorectal Cancer Axis: A Novel Theragnostic Avenue.

J Oncol 2019 17;2019:7406078. Epub 2019 Mar 17.

Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.

The World Health Organization (WHO) considers that obesity has reached proportions of pandemic. Experts also insist on the importance of considering obesity as a chronic disease and one of the main contributors to the worldwide burden of other nontransmissible chronic diseases, which have a great impact on health, lifestyle, and economic cost. One of the most current challenges of biomedical science faces is to understand the origin of the chronic nontransmissible diseases, such as obesity and cancer. Read More

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http://dx.doi.org/10.1155/2019/7406078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441533PMC

Multimodality and Fusion Imaging in Percutaneous Therapy of Tricuspid Regurgitation.

Rev Esp Cardiol (Engl Ed) 2019 May 7;72(5):421-422. Epub 2018 Jul 7.

Servicio de Cardiología, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Universidad Autónoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.rec.2018.04.027DOI Listing

The Mediating Role of Brown Fat and Skeletal Muscle Measured by F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults.

Obesity (Silver Spring) 2019 Apr 21. Epub 2019 Apr 21.

Promoting Fitness & Health Through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Objective: This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal-ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal-ET and WT (as a proxy of peripheral vasoconstriction/vasodilation).

Methods: The levels of BAT were quantified by cold-induced F-fluorodeoxyglucose-positron emission tomography/computed tomography scan and measured the Personal-ET and WT by using iButtons (Maxim Integrated, Dallas, Texas) in 75 participants (74. Read More

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http://dx.doi.org/10.1002/oby.22461DOI Listing

Parenteral drug use as the main barrier to hepatitis C treatment uptake in HIV-infected patients.

HIV Med 2019 Apr 22. Epub 2019 Apr 22.

Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Córdoba, Spain.

Objectives: Our objective was to identify patient factors associated with being untreated for hepatitis C virus (HCV) infection in HIV-coinfected patients.

Methods: A prospective longitudinal study was carried out. HIV-infected patients with active chronic HCV infection included in the HERACLES cohort (NCT02511496) constituted the study population. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hiv.12715
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http://dx.doi.org/10.1111/hiv.12715DOI Listing
April 2019
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Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry.

Inflamm Bowel Dis 2019 Apr 22. Epub 2019 Apr 22.

Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.

Background: Anti-tumor necrosis factor agents (anti-TNFs) are efficacious at preventing the postoperative recurrence (POR) of Crohn disease, as demonstrated in 2 randomized controlled trials. However, real-life data for infliximab or adalimumab in this setting are scarce. Our aim was to assess both the efficiency of anti-TNFs at preventing early POR of Crohn disease in clinical practice and the associated risk factors for POR. Read More

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https://academic.oup.com/ibdjournal/advance-article/doi/10.1
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http://dx.doi.org/10.1093/ibd/izz084DOI Listing
April 2019
2 Reads

Psychopathological disorders in Prader-Willi syndrome.

Endocrinol Diabetes Nutr 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Endocrinología y Nutrición, Hospital Universitari Parc Taulí, Universidad Autónoma de Barcelona, Sabadell (Barcelona), España. Electronic address:

Prader-Willi syndrome is a genetic disorder caused by chromosomal changes in segment 15q11-q13 including cognitive, mental, and behavioral symptoms, as well as a specific physical phenotype. Both the most common psychopathological changes (intellectual disability, obsessions, impulsivity, autism spectrum disorders, self-injuries) and the main psychiatric comorbidities (affective disorders, psychosis, obsessive-compulsive disorder, autism spectrum disorder) are characterized by a great heterogeneity, which warrants the need for better identification of their frequency and clinical signs. In addition to its effects on body compositionand hypotony, growth hormone has been shown to be useful for regulating patient behavior, and psychoactive drugs are also an option. Read More

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http://dx.doi.org/10.1016/j.endinu.2019.03.004DOI Listing

Clarifications to «First described case of coma triggered by retrograde venous air embolism: An exceptional but potentially life-threatening situation».

Neurologia 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.

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http://dx.doi.org/10.1016/j.nrl.2018.12.001DOI Listing

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, 221 84, Lund, Sweden.

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer's disease) mice and found specifically expressed in microglia associated with Aβ plaques. Read More

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http://dx.doi.org/10.1007/s00401-019-02013-zDOI Listing

Smartwatch for the analysis of rest tremor in patients with Parkinson's disease.

J Neurol Sci 2019 Apr 9;401:37-42. Epub 2019 Apr 9.

Medicine Department, Faculty of Medicine, Universidad Complutense Madrid (UCM), Spain; Neurology Department, Hospital Universitario 12 de Octubre, Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain.

Wearable technology used in Parkinson's disease (PD) research has become an increasing focus of interest in this field. Our group assessed the feasibility, clinical correlation, reliability, and acceptance of smartwatches in order to quantify arm resting tremors in PD patients. An Android application on a smartwatch was used to obtain raw data from the smartwatch's gyroscopes. Read More

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http://dx.doi.org/10.1016/j.jns.2019.04.011DOI Listing

Valve-Sparing Repair of Tetralogy of Fallot with Intraoperative Dilation of the Pulmonary Valve. Mid-Term Results.

Semin Thorac Cardiovasc Surg 2019 Apr 18. Epub 2019 Apr 18.

Congenital & Structural Heart Disease Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC); Cardiovascular Surgery, Complejo Hospitalario Universitario de A Coruña (CHUAC). Electronic address:

Objective: Deleterious long-term effects of chronic pulmonary regurgitation after repair of tetralogy of Fallot have become evident during the last decades. Subsequently, some groups have developed strategies to spare the pulmonary valve function at the time of repair with good early results. However, mid-term outcomes are scarce in the literature and in some cases controversial. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2019.04.007DOI Listing
April 2019
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Residual congestion and clinical intuition in decompensated heart failure.

Rev Clin Esp 2019 Apr 17. Epub 2019 Apr 17.

Servicio de Medicina Interna, Hospital Universitario Arnau de Vilanova, Lleida, España; Instituto de Investigación Biomédica Dr. Pifarré, Lleida, España.

Congestive symptoms are the key to recognising decompensated heart failure, whose treatment is based on reducing the congestion until a clinical situation has been reached that allows the patient to be discharged to continue outpatient treatment. The important aspect is not the degree of congestion at admission but rather the congestion that persists after energetic diuretic therapy. The persistence of congestive signs following an apparently correct and effective therapy has been called residual congestion and is associated with a poor prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142565193007
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http://dx.doi.org/10.1016/j.rce.2019.02.004DOI Listing
April 2019
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Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].

Metabolism 2019 Apr 17. Epub 2019 Apr 17.

Pharmacology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.04.009DOI Listing

Fear Extinction Retention: Is It What We Think It Is?

Biol Psychiatry 2019 Feb 19. Epub 2019 Feb 19.

Institute of Neurosciences, Hospital Clínic, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.

There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain extinction memory over time (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00063223193011
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http://dx.doi.org/10.1016/j.biopsych.2019.02.011DOI Listing
February 2019
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Evaluation of two approaches to lysosomal acid lipase deficiency patient identification: An observational retrospective study.

Atherosclerosis 2019 Mar 18;285:49-54. Epub 2019 Mar 18.

Instituto de Investigación Sanitaria Aragón (IIS Aragón), GIIS-012, Zaragoza, 50009, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), CB/06/07/1036, Instituto de Salud Carlos III (ISCIII), Hospital Universitario Miguel Servet, Zaragoza, 50009, Spain; Fundación Española para el Estudio y Terapéutica de la Enfermedad de Gaucher y Otras Lisosomales (FEETEG), Zaragoza, 50008, Spain.

Background And Aims: Lysosomal acid lipase deficiency (LALD) leads to the accumulation of cholesteryl esters and/or triglycerides (TG) in lysosomes due to the lack of the enzyme codified by the LIPA gene. The most common symptoms are dyslipidaemia and hypertransaminasemia, together with manifestations common to other lysosomal storage disorders (LSDs), including visceromegalies and elevated plasma biomarkers. Alteration of the lipid-liver profile (LLP) has been widely applied as a criterion for LALD screening, but the usefulness of biomarkers has not yet been explored. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.013DOI Listing

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

HIPS - Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research (HZI), Saarland University, Universitätscampus E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany. Electronic address:

Predictive in vitro models are valuable alternatives to animal experiments for evaluating the transport of molecules and (nano)particles across biological barriers. In this work, an improved triple co-culture of air-blood barrier was set-up, being exclusively constituted by human cell lines that allowed to perform experiments at air-liquid interface. Epithelial NCI-H441 cells and endothelial HPMEC-ST1. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.037DOI Listing

A novel mutation in the gene expands the phenotype of Alexander disease.

J Med Genet 2019 Apr 19. Epub 2019 Apr 19.

Neurometabolic Diseases Laboratory, Institut d'Investigacio Biomedica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat (Barcelona), Catalonia, Spain

Background: Alexander disease, an autosomal dominant leukodystrophy, is caused by missense mutations in . Although mostly diagnosed in children, associated with severe leukoencephalopathy, milder adult forms also exist.

Methods: A family affected by adult-onset spastic paraplegia underwent neurological examination and cerebral MRI. Read More

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105959
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http://dx.doi.org/10.1136/jmedgenet-2018-105959DOI Listing
April 2019
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6.335 Impact Factor

Assessment of analgesia, sedation, physical restraint and delirium in patients admitted to Spanish intensive care units. Proyecto ASCyD.

Enferm Intensiva 2019 Apr 16. Epub 2019 Apr 16.

Grupo de Trabajo de Analgesia, Sedación, Contenciones y Delirio de la Sociedad Española de Enfermería Intensiva y Unidades Coronarias (GT-ASCyD-SEEIUC), España; Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, España; Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Majadahonda, Madrid, España.

Aims: Main aim: To determine the Spanish intensive care units (ICU) that assess and record pain levels, sedation/agitation, delirium and the use of physical restraint (PR) as standard practice. Secondary aims: To determine the use of validated assessment tools and to explore patients' levels of pain and sedation/agitation, the prevalence of delirium, and the use of PR.

Method: An observational, descriptive, cross-sectional, prospective and multicentre study using an ad hoc survey with online access that consisted of 2 blocks. Read More

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http://dx.doi.org/10.1016/j.enfi.2018.11.002DOI Listing

Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial.

Lancet Diabetes Endocrinol 2019 May;7(5):e6-e17

Centro de Investigación Biomédica en Red Fisiopatologia de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain; Department of Internal Medicine and Lipid Clinic, Department of Endocrinology and Nutrition, University of Barcelona, Barcelona, Spain.

Background: Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese.

Methods: PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain. Read More

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http://dx.doi.org/10.1016/S2213-8587(19)30074-9DOI Listing

3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Chitosan (Ch) is used in different biomedical applications to promote tissue repair. However, tissue injury caused by biomaterial implantation lead to the release of danger signals that engage different inflammatory pathways on the host. Different implanted materials activate the inflammasome leading to the modulation of the immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.035DOI Listing
April 2019
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Cohort study showed that growth rate increment has not been enough to prevent growth retardation of preterm infants and raised concerns about unbalanced growth.

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Neonatology Department, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Madrid, Spain.

Aim: We describe the postnatal weight gain, linear and head growth trends of surviving preterm infants from 2005 to 2017.

Methods: Multicentre cohort study, including surviving preterm infants < 32 weeks (n=21,084), from the Spanish Neonatal Network database, without major congenital malformations who were less than 50 weeks postmenstrual age at discharge. Outcomes were weight gain (g/kg/day), linear and head growth (cm/week) and changes in weight, length and head circumference z-scores from birth to discharge. Read More

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http://dx.doi.org/10.1111/apa.14819DOI Listing