18,535 results match your criteria Biomedica : revista del Instituto Nacional de Salud[Journal]


Allergic contact dermatitis due to undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Hospital General Universitario de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

Undecylenic acid (CAS no. 112-38-9) has antifungal and antibacterial effects. For this reason, it is used along with imidazole antifungals. Read More

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December 2018

Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.

Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.

Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.

Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More

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December 2018
1 Read

Cis-trans proline isomers in the catalytic domain of calcineurin.

FEBS J 2018 Dec 7. Epub 2018 Dec 7.

BioNMR Laboratory, Inorganic and Organic Chemistry Department, University of Barcelona, Baldiri Reixac 10-12, 08028, Barcelona, Spain.

Calcineurin is an essential calcium activated serine/threonine phosphatase. The six NMR-observable methionine methyl groups in the catalytic domain of human calcineurin Aα (CNA) were assigned and used as reporters of the presence of potential cis-trans isomers in solution. Proline 84 is found in the cis conformation in most calcineurin X-ray structures, and proline 309, which is part of a highly conserved motif in phosphoprotein phosphatases, was modeled with a cis-peptide bond in one of the two molecules present in the asymmetric unit of CNA. Read More

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December 2018
1 Read

Mortality of women with ductal carcinoma in situ of the breast: a population-based study from the Girona province, Spain (1994-2013).

Clin Transl Oncol 2018 Dec 10. Epub 2018 Dec 10.

Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004, Girona, Spain.

Purpose: We aim to comprehensively describe the incidence and mortality trends of ductal carcinoma in situ (DCIS) in the Girona province, Spain (1994-2013) and to estimate the all-cause mortality excess risk of diagnosed women.

Methods: Age-standardized rates of DCIS were estimated between 1994 and 2013. Standard mortality ratios (SMR) and absolute excess mortality were calculated overall and by tumor and patient characteristics. Read More

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December 2018

Genetic Lineage Tracing of Biliary Epithelial Cells.

Methods Mol Biol 2019 ;1905:45-57

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Lineage tracing of liver cells is a powerful tool to understand liver embryonic development, healthy liver cell homeostasis, tissue repair, and regeneration. Lineage tracing of biliary epithelial cells (BECs) in the adult liver has been used to assess the contribution of the biliary epithelium to liver injury, regeneration, and disease. These studies have shown the contribution of BECs to the expansion of ductular reaction (DR) and liver progenitor cells (LPCs) and eventually the generation of new hepatocytes. Read More

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January 2019

PhenoMeNal: Processing and analysis of Metabolomics data in the Cloud.

Gigascience 2018 Dec 7. Epub 2018 Dec 7.

Cheminformatics and Computational Metabolomics, Institute for Analytical Chemistry, Lessingstr. 8, 07743 Jena, Germany.

Background: Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism's metabolism. The research field is dynamic and expanding with applications across biomedical, biotechnological and many other applied biological domains. Its computationally-intensive nature has driven requirements for open data formats, data repositories and data analysis tools. Read More

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December 2018
2 Reads

Small extracellular vesicles in rat serum contain astrocyte-derived protein biomarkers of repetitive stress.

Int J Neuropsychopharmacol 2018 Dec 8. Epub 2018 Dec 8.

Centro de Investigación Biomédica, Universidad de los Andes, Chile.

Background: Stress precipitates mood disorders, characterized by a range of symptoms present in different combinations, suggesting the existence of disease subtypes. Using an animal model, we previously described that repetitive stress via restraint or immobilization induced depressive-like behaviors in rats that were differentially reverted by a serotonin- or noradrenaline-based antidepressant drug, indicating that different neurobiological mechanisms may be involved. The forebrain astrocyte protein aldolase C, contained in small extracellular vesicles (sEVs), was identified as a potential biomarker in the cerebrospinal fluid, however its specific origin remains unknown. Read More

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December 2018

Deciphering the complexity of human noncoding promoter-proximal transcriptome.

Bioinformatics 2018 Dec 10. Epub 2018 Dec 10.

Institute of Oncology Research (IOR), Università della Svizzera italiana (USI), Bellinzona, Switzerland.

Motivation: Long noncoding RNAs (lncRNAs) have gained increasing relevance in epigenetic regulation and nuclear functional organization. High-throughput sequencing approaches have revealed frequent noncoding transcription in promoter-proximal regions. However, a comprehensive catalogue of promoter-associated RNAs (paRNAs) and an analysis of the possible interactions with neighboring genes and genomic regulatory elements are missing. Read More

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December 2018
1 Read

Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.

Ann Intern Med 2018 Dec 11. Epub 2018 Dec 11.

National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina (C.R.W., D.P.S.).

Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated.

Objective: To characterize breast cancer risk in relation to recent childbirth. Read More

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December 2018

Tuning the deposition parameters for optimizing the faradaic and non-faradaic electrochemical performance of nanowire array-shaped ITO electrodes prepared by electron beam evaporation.

Nanoscale 2018 Dec 10. Epub 2018 Dec 10.

Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, E-08193 Bellaterra, Spain.

Nanostructured indium tin oxide (ITO) surfaces present an interesting yet unusual combination of properties (high electrical conductivity and optical transparency) at a high surface-to-volume ratio. Thus, previous studies presented nanostructured ITO electrodes as potentially suitable platforms for electrochemical biosensors, but still there is a lack of research on the optimization of preparation methods for such electrodes. We present a systematic study on the properties of nanostructured ITO electrodes prepared by physical deposition, where the substrate temperature was tuned for achieving the best combination of structural properties (namely electrical conductivity and optical transparency) and electrochemical performance. Read More

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December 2018

The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects.

Front Mol Neurosci 2018 26;11:426. Epub 2018 Nov 26.

3D Lab, Development, Differentiation and Degeneration, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CIB/CSIC), Madrid, Spain.

Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied in the field of endocrinology, the bioactivity of the proinsulin molecule itself has received much less attention. Insulin binds to isoforms A and B of the insulin receptor (IR) with high affinity. Read More

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November 2018

polymorphisms and antibody-mediated-rejection after heart transplantation.

Oncotarget 2018 Nov 9;9(88):35799-35800. Epub 2018 Nov 9.

Instituto de Investigación Biomédica de la Universidad de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC)-Universidad de A Coruña, A Coruña, Spain.

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November 2018

Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease.

Oxid Med Cell Longev 2018 8;2018:1435934. Epub 2018 Nov 8.

Instituto de Investigaciones Biomédicas Alberto Sols (IIBM), Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid (CSIC-UAM), 28029 Madrid, Spain.

Mitochondria are highly dynamic and regulated organelles that historically have been defined based on their crucial role in cell metabolism. However, they are implicated in a variety of other important functions, making mitochondrial dysfunction an important axis in several pathological contexts. Despite that conventional biochemical and molecular biology approaches have provided significant insight into mitochondrial functionality, innovative techniques that provide a global view of the mitochondrion are still necessary. Read More

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November 2018

[¿Azitromicina como tratamiento contra Chlamydia trachomatis?]

Gac Med Mex 2018 ;154(6):689-692

Universidad Autónoma de Coahuila, Centro de Investigación Biomédica, Coahuila, México.

Azithromycin and doxycycline effectiveness has been demonstrated in the treatment of urogenital chlamydiasis, which has remained unchanged for a long time. Autoinoculation has been proposed as a method of reinfection and persistence of the disease in women and probably also owing to azithromycin pharmacokinetics in this tissue. With the new diagnostic methods and tests of cure, a difference has been demonstrated in favor of doxycycline in the treatment of rectal chlamydiasis Antimicrobial resistance has not played a relevant role since no treatment-resistant strains have been found in vivo. Read More

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January 2018

Publisher Correction: Novel Urinary Biomarkers For Improved Prediction Of Progressive eGFR Loss In Early Chronic Kidney Disease Stages And In High Risk Individuals Without Chronic Kidney Disease.

Sci Rep 2018 Dec 10;8(1):17822. Epub 2018 Dec 10.

Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Fundación Renal Iñigo Álvarez de Toledo, Universidad Autónoma de Madrid. REDinREN, Avda. Reyes Católicos, 2, 28040, Madrid, Spain.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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December 2018

Physical Activity Is Associated with Attenuated Disease Progression in COPD.

Med Sci Sports Exerc 2018 Dec 7. Epub 2018 Dec 7.

ISGlobal, Barcelona, Spain[ZERO WIDTH SPACE].

Introduction: COPD progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression.

Method: We studied 114 COPD patients from the PAC-COPD cohort [94% male, mean (SD) 70 (8) years of age, 54 (16) FEV1 % predicted] at baseline and 2. Read More

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December 2018

Next Generation Sequencing Analysis in Early Onset Dementia Patients.

J Alzheimers Dis 2018 Dec 3. Epub 2018 Dec 3.

Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than in late onset dementia.

Objective: To identify known and/or novel rare variants in major candidate genes associated to EOD by high-throughput sequencing. Read More

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December 2018

Paradigm changes for diagnosis: using big data for prediction.

Clin Chem Lab Med 2018 Dec 11. Epub 2018 Dec 11.

Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalunya, Spain.

Due to profound changes occurring in biomedical knowledge and in health systems worldwide, an entirely new health and social care scenario is emerging. Moreover, the enormous technological potential developed over the last years is increasingly influencing life sciences and driving changes toward personalized medicine and value-based healthcare. However, the current slow progression of adoption, limiting the generation of healthcare efficiencies through technological innovation, can be realistically overcome by fostering convergence between a systems medicine approach and the principles governing Integrated Care. Read More

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December 2018

Muscle MRI in a large cohort of patients with oculopharyngeal muscular dystrophy.

J Neurol Neurosurg Psychiatry 2018 Dec 8. Epub 2018 Dec 8.

Neuromuscular Disorders Unit, Neurology Department, Hospital de la Santa Creu I Sant Pau, Universidad Autónoma de Barcelona, Barcelona, Spain

Background And Objective: Oculopharyngeal muscular dystrophy (OPMD) is a genetic disorder caused by an abnormal expansion of GCN triplets within the gene. Previous descriptions have focused on lower limb muscles in small cohorts of patients with OPMD, but larger imaging studies have not been performed. Previous imaging studies have been too small to be able to correlate imaging findings to genetic and clinical data. Read More

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December 2018

Biomarkers in lung cancer screening: achievements, promises and challenges.

J Thorac Oncol 2018 Dec 4. Epub 2018 Dec 4.

Solid Tumors Program, Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain; IdiSNA (Navarra Institute for Health Research), Pamplona, Spain; CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Spain; Department of Pathology, Anatomy and Physiology. School of Medicine, University of Navarra, Pamplona, Spain. Electronic address:

The present review is an update of the research and development efforts regarding the use of molecular biomarkers in the lung cancer screening setting. The two main unmet clinical needs, namely, the refinement of risk in order to improve the selection of individuals undergoing screening and the characterization of undetermined nodules found during the CT-based screening process are the object of the biomarkers described in the present review. We first propose some principles to optimize lung cancer biomarker discovery projects. Read More

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December 2018

The association between diabetes and cataract among 42,469 community-dwelling adults in six low- and middle-income countries.

Diabetes Res Clin Pract 2018 Dec 6. Epub 2018 Dec 6.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.

Background: Cataract is a major cause of visual impairment in people with diabetes, yet a paucity of data is available in low- and middle-income countries (LMICs) on this comorbidity. Thus we assessed the association between diabetes and cataract in 6 LMICs.

Methods: Cross-sectional, community-based data from the Study on Global Ageing and Adult Health (SAGE) was analyzed (n=42,469 aged ≥18 years). Read More

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December 2018

Flavor recognition memory related activity of the posterior piriform cortex in adult and aged rats.

Behav Brain Res 2018 Dec 7. Epub 2018 Dec 7.

Departamento de Psicobiología, Instituto de Neurociencias, Centro de Investigación Biomédica, Universidad de Granada, España.

The relationship between the piriform cortex and flavor recognition memory was investigated in adult and aged rats. By using c-Fos immunohistochemistry, we assessed the piriform cortex activity induced by flavor familiarity. The results indicated increased activity in the rostral region of the posterior piriform cortex elicited by the most familiar cider vinegar solution after six exposures. Read More

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December 2018

[Knowledge and attitude among general practitioners in Andalusia (Spain) on the identification of subjects at high risk of breast and colorectal cancer].

Semergen 2018 Oct 24. Epub 2018 Oct 24.

Médico de Familia, Unidad de Gestión Clínica Ciudad Jardín, Distrito Sanitario Málaga-Guadalhorce, Málaga, España. Electronic address:

Aims: To assess the knowledge and attitude among general practitioners in Andalusia on the identification of subjects with elevated risk for breast cancer, colorectal cancer, and hereditary cancers, as well as to detect barriers to accessibility to the screening programs.

Methods: A descriptive, cross-sectional study was conducted based on an online survey of 24 questions. Data are shown as frequencies, and association tests were statistically used. Read More

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October 2018

Immune mechanisms mediating abscopal effects in radioimmunotherapy.

Pharmacol Ther 2018 Dec 5. Epub 2018 Dec 5.

Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA),; Department of Immunology and immunotherapy, University Clinic of Navarra, Pamplona, Spain/; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.

Radiotherapy of cancer has been traditionally considered as a local therapy without noticeable effects outside the irradiated fields. However, ionizing radiation exerts multiple biological effects on both malignant and stromal cells that account for a complex spectrum of mechanisms beyond simple termination of cancer cells. In the era of immunotherapy, interest in radiation-induced inflammation and cell death has considerably risen, since these mechanisms lead to profound changes in the systemic immune response against cancer antigens. Read More

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December 2018

Antisepsis for blood culture extraction. Blood culture contamination rate.

Med Intensiva 2018 Oct 24. Epub 2018 Oct 24.

Unidad de Medicina Intensiva, Hospital Universitario y Politécnico la Fe, Valencia, España.

Blood cultures are the gold standard for the etiological diagnosis of bacteremia, though false-positive results are relatively frequent primarily due to contamination from skin flora during sample extraction. Correct skin antisepsis is important for reducing the bacterial load and opportunities for contamination. However, there is currently no solid consensus on the best antiseptic method. Read More

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October 2018

Kidney, hypertension and complement activation. In search of new therapeutic targets.

Nefrologia 2018 Dec 6. Epub 2018 Dec 6.

UGC de Nefrología, Hospital Universitario Reina Sofía, Córdoba; Instituto Maimónides de Investigación Biomedica de Córdoba (IMIBIC), Córdoba, España. Electronic address:

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December 2018

Antimicrobial coatings prepared from Dhvar-5-click-grafted chitosan powders.

Acta Biomater 2018 Dec 5. Epub 2018 Dec 5.

LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal. Electronic address:

Antimicrobial peptides (AMP) are powerful components of the innate immune system, as they display wide activity spectrum and low tendency to induce pathogen resistance. Hence, the development of AMP-based coatings is a very promising strategy to prevent biomaterials-associated infections. This work aims to investigate if Dhvar-5-chitosan conjugates, previously synthesized by us via azide-alkyne "click" reaction, can be applied as antimicrobial coatings. Read More

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December 2018

Escherichia coli lipopolysaccharide induces alveolar epithelial cell stiffening.

J Biomech 2018 Nov 29. Epub 2018 Nov 29.

Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias CIBERES, Madrid, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain. Electronic address:

Introduction: Application of lipopolysaccharide (LPS) is a widely employed model to mimic acute respiratory distress syndrome (ARDS). Available data regarding LPS-induced biomechanical changes on pulmonary epithelial cells are limited only to P. aeruginosa LPS. Read More

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November 2018

Patients with locally advanced hypopharyngeal carcinoma. Results over a 30-year period.

Acta Otorrinolaringol Esp 2018 Dec 5. Epub 2018 Dec 5.

Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.

Introduction And Objectives: The treatment of locally advanced carcinomas of the hypopharynx may include surgery or several combinations of radiotherapy and chemotherapy as organ preservation strategies. The objective of the present study is to analyze the results of locally advanced hypopharyngeal carcinoma patients treated in a single centre over a 30-year period.

Methods: Retrospective chart review of 278 patients with T3-T4 hypopharyngeal carcinomas treated between 1985 and 2015 at a tertiary institution. Read More

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December 2018

Surface scanning for 3D dose calculation in intraoperative electron radiation therapy.

Radiat Oncol 2018 Dec 7;13(1):243. Epub 2018 Dec 7.

Hospital General Universitario Gregorio Marañón, Unidad de Medicina y Cirugía Experimental (Instituto de Investigación Sanitaria Gregorio Marañón), Madrid, Spain.

Background: Dose calculations in intraoperative electron radiation therapy (IOERT) rely on the conventional assumption of water-equivalent tissues at the applicator end, which defines a flat irradiation surface. However, the shape of the irradiation surface modifies the dose distribution. Our study explores, for the first time, the use of surface scanning methods for three-dimensional dose calculation of IOERT. Read More

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December 2018
2.546 Impact Factor

Social determinants, health status and 10-year mortality among 10,906 older adults from the English longitudinal study of aging: the ATHLOS project.

BMC Public Health 2018 Dec 10;18(1):1357. Epub 2018 Dec 10.

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 Eleftheriou Venizelou Ave, 176 61, Attica, Athens, Greece.

Background: In either rich or poor countries, people's health widely depends on the social conditions in which they live and work - the social determinants of health. The aim of the present work was to explore the association of educational and financial status with healthy aging and mortality.

Methods: Data from the English Longitudinal Study of Aging (ELSA) were studied (n = 10,906 participants, 64 ± 11 years, 55% women). Read More

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December 2018

Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy.

Leuk Lymphoma 2018 Dec 11:1-10. Epub 2018 Dec 11.

g CIBERONC, Instituto Carlos III , Madrid , Spain.

Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. Read More

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December 2018

[Home and Ambulatory Artificial Nutrition (NADYA) Report. Home Parenteral Nutrition in Spain, 2017].

Nutr Hosp 2018 Dec 3;35(6):1491-1496. Epub 2018 Dec 3.

1. Hospital General Universitario de Alicante, Alicante, España. 2. Fundación para el Fomento de la Investigación Sanitaria y Biomédica (ISABIAL-FISABIO), Alicante, España..

Aim: to communicate HPN data obtained from the HPN registry of the NADYA-SENPE group (www.nadya-senpe.com) for the year 2017. Read More

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December 2018

[How to improve hydration and fluid intake in institutionalized older people? A scientific literature review].

Nutr Hosp 2018 Dec 3;35(6):1441-1449. Epub 2018 Dec 3.

Departamento de Enfermería y Fisioterapia, Universidad de Lleida, Lleida Grupo de Investigación en Cuidados en Salud (GRECS), Instituto de Investigación Biomédica de Lleida, Lleida.

Background: residents are vulnerable to suffer of dehydration due to physiological changes and the physical and cognitive limitations.

Aim: to handle this situation, it has been decided to evaluate the interventions which are carried out for the management of dehydration and low fluid intake in older people living in nursing homes.

Methods: the revised scientific literature review methodology of PRISMA was applied. Read More

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December 2018

Effect of symbiotic supplementation on fecal calprotectin levels and lactic acid bacteria, Bifidobacteria, Escherichia coli and Salmonella DNA in patients with cervical cancer.

Nutr Hosp 2018 Dec 3;35(6):1394-1400. Epub 2018 Dec 3.

Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS).

Background: patients with cervical cancer (CC) receiving chemotherapy and radiotherapy have several gastrointestinal adverse effects.

Objective: to evaluate the effect of dietary symbiotic supplementation on fecal calprotectin (FCP), bacterial DNA levels, and gastrointestinal adverse effects in patients with CC.

Methods: clinical, controlled, randomized, double-blind trial. Read More

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December 2018

A gradient-based, GPU-accelerated, high-precision contour-segmentation algorithm with application to cell membrane fluctuation spectroscopy.

PLoS One 2018 6;13(12):e0207376. Epub 2018 Dec 6.

Mechanics of Biological Membranes and Biorheology, Dpto. Química Física I, Universidad Complutense, Madrid, Spain.

We present a novel intensity-gradient based algorithm specifically designed for nanometer-segmentation of cell membrane contours obtained with high-resolution optical microscopy combined with high-velocity digital imaging. The algorithm relies on the image oversampling performance and computational power of graphical processing units (GPUs). Both, synthetic and experimental data are used to quantify the sub-pixel precision of the algorithm, whose analytic performance results comparatively higher than in previous methods. Read More

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December 2018

Differences in peripheral and tissue immune cell populations following hematopoietic stem cell transplantation in Crohn's disease patients.

J Crohns Colitis 2018 Dec 6. Epub 2018 Dec 6.

Department of Gastroenterology, IDIBAPS, Hospital Clínic, Barcelona, Spain.

Background And Aims: Recent studies show the efficacy of autologous hematopoietic stem cell transplantation (HSCT) in severely refractory Crohn's disease (CD) patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available.

Methods: We followed a group of CD patients (n=18) receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. Read More

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December 2018
2 Reads
6.234 Impact Factor

Assessment of Frequency and Reporting of Changes in Cancer Trial Design After Initiation of Patient Accrual.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Division of Medical Oncology & Hematology, Department of Medicine, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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December 2018

Is Vibration Training Good for Your Bones? An Overview of Systematic Reviews.

Biomed Res Int 2018 4;2018:5178284. Epub 2018 Nov 4.

Faculty of Health and Sport Science (FCSD), Department of Physiatry and Nursing. Universidad de Zaragoza, Ronda Misericordia 5, 22001 Huesca, Spain.

Whole-body vibration (WBV) intervention studies and reviews have been increasing lately. However, the results regarding its effects on bone tissue in different populations are still inconclusive. The goal of this overview was to summarize systematic reviews assessing the effects of WBV training on bone parameters. Read More

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November 2018
1 Read

The Outer Membrane Vesicles of ATCC 7966: A Proteomic Analysis and Effect on Host Cells.

Front Microbiol 2018 16;9:2765. Epub 2018 Nov 16.

Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.

Gram-negative bacteria release outer membrane vesicles (OMVs) into the extracellular environment. OMVs have been studied extensively in bacterial pathogens, however, information related with the composition of OMVs is missing. In this study we analyzed the composition of purified OMVs from ATCC 7966 by proteomics. Read More

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November 2018
2 Reads

Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant.

Infect Drug Resist 2018 8;11:2207-2210. Epub 2018 Nov 8.

Liver Unit, Liver Disease Laboratory-Viral Hepatitis, Internal Medicine Department, Vall d'Hebron Institut of Research (VHIR)-Vall d'Hebron University Hospital(HUVH), 08035, Barcelona, Spain,

Background: Controversy is ongoing about whether a minority mutant present at frequencies below 15% may be clinically relevant and should be considered to guide treatment.

Methods: Resistance-associated substitution (RAS) studies were performed in patients before and at failure of antiviral treatments using Next-generation hepatitis C virus (HCV) sequencing (NGS).

Results: We have found two patients with genotype 1a infection having RAS in 3. Read More

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November 2018

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis.

Cell Death Dis 2018 Dec 5;9(12):1166. Epub 2018 Dec 5.

CellCOM research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, 84, 15006 A, Coruña, Spain.

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to other wound-healing disorders, chondrocytes from OA patients show a chronic increase in the gap junction channel protein connexin43 (Cx43), which regulates signal transduction through the exchange of elements or recruitment/release of signalling factors. Read More

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December 2018

Compassionate Use of Lumacaftor/Ivacaftor in Cystic Fibrosis: Spanish Experience.

Arch Bronconeumol 2018 Dec 7;54(12):614-618. Epub 2018 Jul 7.

Hospital San Pedro de Alcántara, Cáceres, Spain.

Background: The most common cystic fibrosis (CF)-causing mutation is deltaF508 (F508del), which is present in 28% of CF Spanish patients. While the literature based on real-life studies on CF patients homozygous F508del treated with lumacaftor/ivacaftor is limited, it demonstrates the need for better strategies to prevent related adverse events (AEs) as well as the development of newer drugs.

Methods: We conducted a multicenter, retrospective, observational study to describe the effects of lumacaftor/ivacaftor treatment in real-life in Spain. Read More

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December 2018
1 Read

The impact of the economic recession on inequalities in induced abortion in the main cities of Spain.

Eur J Public Health 2018 Nov 30. Epub 2018 Nov 30.

Dirección General de Salud Pública, Consejería de Sanidad, Madrid, Spain.

The aim of this study was to analyse the trends in socioeconomic inequalities in induced abortion during the pre-crisis and crisis periods in the postcodes of two major cities of Spain. Ecological regression model showed that rates of induced abortion tended to increase between the two pre-crisis periods, but remained stable between the second pre-crisis period and the crisis period. In addition, we observed socioeconomic inequalities in induced abortion in both cities and in all age groups, and that these inequalities persisted across the three study periods. Read More

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November 2018
1 Read

Hypertension and high ankle brachial index: the overlooked combination.

J Hypertens 2019 Jan;37(1):92-98

Vascular Health Research Group of Girona (ISV-Girona). Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Girona.

Objective: Assessment of asymptomatic organ damage in the management of hypertension includes low (<0.9) ankle brachial index (ABI) values. No recommendations are given for patients with high ABI (≥1. Read More

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January 2019

Optimization and Pharmacological Characterization of Receptor-Mediated G Activation in Postmortem Human Prefrontal Cortex.

Basic Clin Pharmacol Toxicol 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Neuropharmacology, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), University of the Balearic Islands (UIB), and Institut d'investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain.

The biochemical abnormalities in transmembrane signal transduction mediated through G protein-coupled receptors (GPCRs) have been postulated as underlying pathophysiology of psychiatric diseases such as schizophrenia and mood disorders. In the present study, the experimental conditions of agonist-induced [ S]GTPγS binding in postmortem human brain membranes were optimized, and the responses induced by a series of agonists were pharmacologically characterized. The [ S]GTPγS binding assay was performed in postmortem human prefrontal cortical membranes by means of filtration techniques, and standardized as to GDP concentration, membrane protein content, MgCl and NaCl concentrations in assay buffer, incubation period, and effect of white matter contamination. Read More

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December 2018
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Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects.

Sci Rep 2018 Nov 30;8(1):17518. Epub 2018 Nov 30.

Unidad de Gestión Clínica Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Málaga, Spain.

Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the potential association between obesity and mental health. Read More

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November 2018
5.078 Impact Factor

[Obstructive tracheobronchitis due to Aspergillus fumigatus in an immunocompetent patient].

Rev Iberoam Micol 2018 Nov 29. Epub 2018 Nov 29.

Servicio de Microbiología, Hospital Universitario Puerta del Mar, Cádiz, España; Instituto de Investigación Biomédica de Cádiz (INiBICA), Cádiz, España.

Background: Aspergillus tracheobronchitis (ATB) is an uncommon type of invasive pulmonary aspergillosis in which fungal involvement is limited to the tracheobronchial tree. While the more severe forms, such as pseudomembranous and ulcerative ATB, occur almost exclusively in immunocompromised patients, the milder obstructive form may occur in patients without immune deficiency.

Case Report: The case of a 32 year-old man with no previous history of illness, who was evaluated for recurrent right lower lobe pneumonia, is presented. Read More

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November 2018

Acute liver failure due to immune-mediated hepatitis successfully managed with plasma exchange: New settings call for new treatment strategies?

J Hepatol 2018 Nov 28. Epub 2018 Nov 28.

Liver Unit, Internal Medicine Department, Vall d'Hebron Hospital, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.

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November 2018

Changes in frailty status in a community-dwelling cohort of older adults: The VERISAÚDE study.

Maturitas 2019 Jan 15;119:54-60. Epub 2018 Nov 15.

Universidade da Coruña, Gerontology Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, 15071 A Coruña, Spain. Electronic address:

Objectives: Greater understanding of changes in the degree of frailty is important for clarifying the natural history of frailty and may help clinical decision-making regarding preventive interventions. The objectives of this study were to explore natural frailty transition rates at 1-year follow-up and to identify the main determinants of such transitions.

Study Design: Prospective longitudinal study covering a representative sample of community-dwelling older adults aged ≥65 years (n = 749) at baseline, and transition information at 1-year follow-up (n = 537). Read More

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January 2019