19,225 results match your criteria Biomedica : revista del Instituto Nacional de Salud[Journal]


Endometriosis-associated ovarian cancer: What have we learned so far?

Clin Chim Acta 2019 Feb 15. Epub 2019 Feb 15.

Division of Laboratory Medicine, Asia University Hospital, Asia University, Taichung, Taiwan; Deparment of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan; Deparment of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan; Deparment of Nursing, Asia University, Taichung, Taiwan. Electronic address:

Endometriosis is defined as the presence of ectopic endometrial tissue outside of the uterine cavity, most commonly in the ovaries and peritoneum. It is a complex disease that is influenced by multiple factors. It is also a common gynecological disorder and affects approximately 10-15% of all women of reproductive age. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.016DOI Listing
February 2019

[Perfectionism and high intellectual capacity].

Medicina (B Aires) 2019 ;79 Suppl 1:33-37

Centro de Investigación en Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, España.

Perfectionism is a psychological construct related o excellence and an optimal manifestation of high intellectual ability (HIA). The main goal of the present work was to compare types and dimensions of perfectionism in students with HIA and an age-gender matched comparison group. We selected 137 participants with diagnosis of HIA and a comparison group of 137 matched by gender and age. Read More

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January 2019

Identification of a novel HLA-B*40 variant allele, B*40:405 by next generation sequencing.

HLA 2019 Feb 18. Epub 2019 Feb 18.

Department of Laboratory Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

The new allele, HLA-B*40:405 differs from B*40:02:01:01 by one nucleotide substitution at codon 304. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/tan.13492DOI Listing
February 2019

ACROSTART: A retrospective study of the time to achieve hormonal control with lanreotide Autogel treatment in Spanish patients with acromegaly.

Endocrinol Diabetes Nutr 2019 Feb 14. Epub 2019 Feb 14.

Endocrinology Department, Hospital General Universitario de Alicante-ISABIAL-FISABIO, Alicante, Spain.

Objectives: The ACROSTART study was intended to determine the time to achieve normalization of GH and IGF-I levels in responding patients with acromegaly administered different dosage regimens of lanreotide Autogel (Somatuline Autogel).

Methods: From March 2013 to October 2013, clinical data from 57 patients from 17 Spanish hospitals with active acromegaly treated with lanreotide for ≥4 months who achieved hormonal control (GH levels <2.5ng/ml and/or normalized IGF-I levels in ≥2 measurements) were analyzed. Read More

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http://dx.doi.org/10.1016/j.endinu.2018.12.004DOI Listing
February 2019

Chronic hepatitis C infection: An independent risk factor for subclinical atheromatosis.

Rev Clin Esp 2019 Feb 14. Epub 2019 Feb 14.

Unidad de Detección y Tratamiento de Enfermedades Aterotrombóticas (UDETMA), Hospital Universitario Arnau de Vilanova (Grupo de Investigación Translacional Vascular y Renal, IRBLleida), Lleida, España; Instituto de Investigación Biomédica, Lleida, España.

Background: The association between subclinical atheromatosis and chronic hepatitis C virus (HCV) infection is unknown but is relevant now that antivirals are improving the survival of patients with the infection.

Objectives: To determine whether HCV is an independent risk factor for subclinical atheromatosis and to analyse the changes in lipid profiles according to viral RNA levels and hepatic fibrosis.

Patients And Methods: We conducted an observational, cross-sectional study that included 102 HCV-positive patients and 102 HCV-negative patients with parity in terms of sex and age, with no history of cardiovascular or kidney disease or diabetes. Read More

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http://dx.doi.org/10.1016/j.rce.2018.12.007DOI Listing
February 2019

Urinary infection in the elderly.

Rev Clin Esp 2019 Feb 14. Epub 2019 Feb 14.

Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla (HUMV), Santander, Cantabria, España. Electronic address:

Introduction: Urinary tract infections (UTIs) are one of the most frequent infections. In the elderly, they have multiple comorbidities. The objective of this work is to describe the clinical and microbiological epidemiology of elderly persons admitted for UTIs and to evaluate the suitability of empirical treatments and their implications regarding mortality. Read More

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http://dx.doi.org/10.1016/j.rce.2018.10.009DOI Listing
February 2019

The controversy of neoadjuvant therapy in rectal cancer.

Cir Esp 2019 Feb 14. Epub 2019 Feb 14.

Gastrointestinal and Pancreatic Oncology Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España.

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http://dx.doi.org/10.1016/j.ciresp.2019.01.004DOI Listing
February 2019

Association between high levels of inflammatory markers and cognitive outcomes at 4 years of age: The Rhea mother-child cohort study, Crete, Greece.

Cytokine 2019 Feb 14;117:1-7. Epub 2019 Feb 14.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.

There is growing evidence associating inflammatory markers in complex, higher order neurological functions, such as cognition and memory. We examined whether high levels of various inflammatory markers are associated with cognitive outcomes at 4 years of age in a mother-child cohort in Crete, Greece (Rhea study). We included 642 children in this cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.010DOI Listing
February 2019

Long-term outcomes with subcutaneous C1-inhibitor replacement therapy for prevention of hereditary angioedema attacks.

J Allergy Clin Immunol Pract 2019 Feb 14. Epub 2019 Feb 14.

CSL Behring LLC, King of Prussia, PA, USA.

Background: For the prevention of attacks of hereditary angioedema (HAE), the efficacy and safety of subcutaneous human C1-esterase inhibitor (C1-INH[SC]; HAEGARDA, CSL Behring) was established in the 16-week COMPACT trial.

Objective: To assess the long-term safety, occurrence of angioedema attacks, and use of rescue medication with C1-INH(SC).

Methods: Open-label, randomised, parallel-arm extension of COMPACT across 11 countries. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.054DOI Listing
February 2019

Facilitated Transfemoral Access by Shockwave Lithoplasty for Transcatheter Aortic Valve Replacement.

JACC Cardiovasc Interv 2019 Feb 7. Epub 2019 Feb 7.

Servicio de Cardiología, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca, Facultad de Medicina, Universidad de Salamanca, y CIBERCV, Salamanca, Spain.

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http://dx.doi.org/10.1016/j.jcin.2018.11.041DOI Listing
February 2019

[Use of off-label drugs in neonatal intensive care].

An Pediatr (Barc) 2019 Feb 13. Epub 2019 Feb 13.

Unidad de Epidemiología Clínica y Bioestadística, Complexo Hospitalario Universitario A Coruña (CHUAC)-Instituto de Investigación Biomédica A Coruña (INIBIC) Sergas, A Coruña, España.

Objective: To evaluate the prevalence of non-approved prescriptions (off-label and unlicensed) in a Neonatal Intensive Care Unit (NICU), and to describe factors of the neonate associated with its use.

Materials And Methods: Observational prospective study in a level III NICU during a 6-month period. Every prescription was analysed using the summary of product characteristics as a reference. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.12.015DOI Listing
February 2019

Ten-year outcomes after Roux-en-Y gastric bypass and sleeve gastrectomy: an observational nonrandomized cohort study.

Surg Obes Relat Dis 2019 Jan 29. Epub 2019 Jan 29.

Endocrinology and Diabetes Department, Obesity Unit, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. Electronic address:

Background: Sleeve gastrectomy (SG) has replaced Roux-en-Y gastric bypass (RYGB) as the most commonly performed bariatric surgery procedure. Data on the long-term (up to 10 yr) outcomes after SG is scarce. No previous study has compared the long-term outcomes between RYGB and SG. Read More

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http://dx.doi.org/10.1016/j.soard.2019.01.020DOI Listing
January 2019

Patterns of recovery course in early intervention for FIRST episode non-affective psychosis patients: The role of timing.

Schizophr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain.

Background: Prevention of symptom relapse and promotion of functional recovery are the two main goals of early intervention following a first episode of non-affective psychosis (FEP). The identification of patterns of recovery is important in developing and implementing recovery focused interventions at set time interval.

Method: Patterns of recovery course, in terms of symptomatic and functional remission, were explored at 1 and 3-year follow-up in a sample of 373 consecutive FEP patients. Read More

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http://dx.doi.org/10.1016/j.schres.2019.01.032DOI Listing
February 2019

Comparison of TSNAs concentration in saliva according to type of tobacco smoked.

Environ Res 2018 Dec 6;172:73-80. Epub 2018 Dec 6.

Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Sant Cugat del Vallès, Barcelona, Spain; Tobacco Control Unit, Cancer Prevention and Control Program, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Cancer Prevention and Control Group, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Objective: To compare tobacco-specific nitrosamines (TSNAs) measured in saliva according to different types of tobacco smoked in a sample of smokers of the city of Barcelona (Spain).

Methods: We used data from a cross-sectional study of a sample of the adult smoking population of Barcelona, Spain in 2013-2014 (n = 165). We classified smokers in five groups according to the type of tobacco smoked: a) manufactured cigarettes only, b) roll-your-own (RYO) cigarettes only, c) dual smokers (both manufactured and RYO cigarettes), d) manufactured plus other types of tobacco products different from RYO and e) other types of tobacco products different from manufactured and RYO cigarettes. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.006DOI Listing
December 2018

Ability of a urine gene expression classifier to reduce the number of follow-up cystoscopies in bladder cancer patients.

Transl Res 2019 Feb 7. Epub 2019 Feb 7.

Department and Laboratory of Urology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre de Recerca Biomèdica CELLEX, Universitat de Barcelona, Barcelona, Spain. Electronic address:

This study aimed to improve our previous urine gene expression classifiers focusing on the detection of non-high-risk non-muscle-invasive bladder cancer (NMIBC), and develop a new classifier able to decrease the frequency of cystoscopies during bladder cancer (BC) patients' surveillance. A total of 597 urines from BC patients, controls and patients in follow-up for BC (PFBC) were included. The study has 3 phases. Read More

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http://dx.doi.org/10.1016/j.trsl.2019.02.003DOI Listing
February 2019

Synovial fluid leukocyte count in asymptomatic hyperuricaemia with crystal deposition: a proof-of-concept study.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Sección de Reumatología, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario de Alicante, Spain.

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http://dx.doi.org/10.1093/rheumatology/kez023DOI Listing
February 2019

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.

Cell Death Differ 2019 Feb 15. Epub 2019 Feb 15.

Redox Homeostasis Group, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013, Sevilla, Spain.

In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, whether and how changes in the cellular redox status may affect protein aggregation is unknown. Here, we show that C. Read More

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http://dx.doi.org/10.1038/s41418-018-0270-9DOI Listing
February 2019

Epidemiology of influenza in pregnant women hospitalized with respiratory illness in Moscow, 2012/2013-2015/2016: a hospital-based active surveillance study.

BMC Pregnancy Childbirth 2019 Feb 15;19(1):72. Epub 2019 Feb 15.

Ministry of Health of the Russian Federation, FSBI "N.F. Gamaleya NRCEM", 16, Gamaleya str, Moscow, Russia Moscow, 123098, Russian Federation.

Background: To better understand the impact of seasonal influenza in pregnant women we analyzed data collected during four seasons at a hospital for acute respiratory infection that specializes in treating pregnant women.

Methods: This was a single-center active surveillance study of women 15-44 years of age hospitalized for acute respiratory diseases between 2012/2013 and 2015/2016 in Moscow, Russian Federation. Women had to have been hospitalized within 7 days of the onset of symptoms. Read More

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http://dx.doi.org/10.1186/s12884-019-2192-zDOI Listing
February 2019

Structural assessments in decellularized extracellular matrix of porcine semilunar heart valves: Evaluation of cell niches.

Xenotransplantation 2019 Feb 16:e12503. Epub 2019 Feb 16.

Escola de Medicina, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Tissue-engineered heart valves aim to reproduce the biological properties of natural valves with anatomically correct structure and physiological performance. The closest alternative to creating an ideal heart valve substitute is to use decellularized porcine heart valves, due to their anatomy and availability. However, the immunological barrier and the structural maintenance limit the long-term physiological performance of decellularized porcine heart valves. Read More

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http://dx.doi.org/10.1111/xen.12503DOI Listing
February 2019

Reply to «Considerations in traumatic brain injury in the emergency department».

Neurocirugia (Astur) 2019 Feb 12. Epub 2019 Feb 12.

Grupo de Investigación transversal de la Urgencia y Emergencia, Institut de Recerca Biomèdica de Lleida, Lleida, España. Electronic address:

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http://dx.doi.org/10.1016/j.neucir.2019.01.004DOI Listing
February 2019

Small Airway Dysfunction in Children With Controlled Asthma.

Arch Bronconeumol 2019 Feb 12. Epub 2019 Feb 12.

Sección de Neumología Infantil, Hospital Universitario Donostia, San Sebastián, España; Departamento de Pediatría, Universidad del País Vasco (UPV/EHU), San Sebastián, España; Centro de Investigación Biomédica en Red, Enfermedades Respiratorias (CIBERES), San Sebastián, España. Electronic address:

Introduction: Asthma is characterized by chronic inflammation of the central and distal airways. The aim of this study was to assess the small airway (SA) of children with moderate-severe asthma with normal FEV1.

Methods: This was an open-label, prospective, observational, cross-sectional study with consecutive inclusion of patients with moderate-severe asthma, receiving standard clinical treatment, with normal baseline FEV. Read More

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http://dx.doi.org/10.1016/j.arbres.2018.08.005DOI Listing
February 2019

CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies.

Redox Biol 2019 Feb 6;22:101118. Epub 2019 Feb 6.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria La Paz (IdiPaz), Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Madrid, Spain; Department of Biochemistry, School of Medicine, Universidad Autónoma de Madrid, Spain. Electronic address:

TAU protein aggregation is the main characteristic of neurodegenerative diseases known as tauopathies. Low-grade chronic inflammation is also another hallmark that indicates crosstalk between damaged neurons and glial cells. Previously, we have demonstrated that neurons overexpressing TAU release CX3CL1, which activates the transcription factor NRF2 signalling to limit over-activation in microglial cells in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101118DOI Listing
February 2019

Rapid assessment of enhanced safety surveillance for influenza vaccine.

Public Health 2019 Feb 12;168:137-141. Epub 2019 Feb 12.

Dirección General de Salud Pública, Conselleria de Sanidad Universal y Salud Pública, Valencia, Spain.

Objectives: The enhanced safety surveillance for seasonal influenza vaccines established by the European Medicines Agency is required each season. Therefore, a registry capable of rapidly detecting and evaluating potential new safety concerns is needed. The aim of the study is to demonstrate the effectiveness of the vaccine information system of the Valencia region to make a rapid assessment of the influenza vaccine safety and describe the safety of the two vaccine types used in the 2017/2018 season. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.013DOI Listing
February 2019

Common Polygenic Variations for Psychiatric Disorders and Cognition in Relation to Brain Morphology in the General Pediatric Population.

J Am Acad Child Adolesc Psychiatry 2019 Jan 9. Epub 2019 Jan 9.

Erasmus University Medical Center, Rotterdam, the Netherlands.

Objective: To examine the relationship between polygenic scores (PGS) for five major psychiatric disorders and two cognitive traits with brain MRI morphological measurements in a large population-based sample of children. Additionally, we tested whether differences in brain morphology mediated associations between PGS for psychiatric disorders and related behavioral phenotypes.

Method: The participants included 1,139 children from the Generation R Study assessed at 10 years-of-age with genotype and neuroimaging data available. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193000
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http://dx.doi.org/10.1016/j.jaac.2018.09.443DOI Listing
January 2019
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Inflammation status in HIV-positive individuals correlates with changes in bone tissue quality after initiation of ART.

J Antimicrob Chemother 2019 Feb 14. Epub 2019 Feb 14.

Infectious Diseases Department, Hospital del Mar Research Institute, Barcelona, Spain.

Background: The mechanisms behind ART-induced bone changes in HIV-infected patients are poorly known. We aimed to analyse changes in inflammatory and bone markers in HIV after tenofovir disoproxil fumarate initiation, and the associations with changes in the bone strength parameters.

Methods: HIV-positive participants starting tenofovir disoproxil fumarate-based ART underwent dual-energy X-ray absorptiometry (QDR 4500 SL®, Hologic, Waltham, MA, USA) for bone mineral density (BMD), a microindentation test (OsteoProbe®, Active Life Scientific, Santa Barbara, CA, USA) for bone quality [bone material strength index (BMSi)] and phlebotomy at baseline and 48 weeks after ART. Read More

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http://dx.doi.org/10.1093/jac/dkz014DOI Listing
February 2019

Antibiotic resistance: Microbiological profile of urinary tract infections in Mexico.

Cir Cir 2019 ;87(2):176-182

Departamento de Inmunología, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.

Objective: The objective of this study was to describe the prevalence, microbiological profile, bacterial resistance, and the sensitivity to antibiotics of microorganisms causing urinary tract infection (UTI) at a single-site tertiary referral hospital in the western region of Mexico.

Methods: A total of 5895 culture samples processed at the microbiology laboratory from August 1, 2014, to July 31, 2015, were analyzed.

Results: A total of 5895 samples for urine cultures (UC) were collected, of which 3363 were taken in women (57. Read More

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http://dx.doi.org/10.24875/CIRU.18000494DOI Listing
January 2019

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology.

Expert Opin Drug Deliv 2019 Feb 15. Epub 2019 Feb 15.

a CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde , Rua Central de Gandra 1317, 4585-116 Gandra , Portugal.

Introduction: The blood-brain barrier (BBB) is a highly limiting barrier that prevents the brain from contacting with several circulating molecules, including harmful agents. However, certain systemic nutrients and macromolecules are able to cross the BBB and reach the brain parenchyma, involving the interaction with multiple receptors and/or transporters at BBB surface. Nanotechnology allows the creation of drug vehicles, functionalized with targeting ligands for binding specific BBB receptors and/or transporters, hence triggering the transport through this biobarrier. Read More

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http://dx.doi.org/10.1080/17425247.2019.1583205DOI Listing
February 2019

Meta-analysis of three-in-one single capsule bismuth-containing quadruple therapy for the eradication of Helicobacter pylori.

Helicobacter 2019 Feb 14:e12570. Epub 2019 Feb 14.

Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Background: Bismuth-containing quadruple therapy has been suggested as first-line and rescue alternative for Helicobacter pylori eradication. Our objective was to perform a meta-analysis evaluating the efficacy and safety of single capsule Pylera (bismuth, metronidazole, and tetracycline) plus a proton-pump inhibitor (PPI) in any line of treatment.

Methods: Studies were selected up to October 2018. Read More

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http://dx.doi.org/10.1111/hel.12570DOI Listing
February 2019

Progress and Perspectives of Thin Film Kesterite Photovoltaic Technology: A Critical Review.

Adv Mater 2019 Feb 14:e1806692. Epub 2019 Feb 14.

Catalonia Institute for Energy Research (IREC), Jardins de les Dones de Negre 1, 08930, Sant Adrià de Besòs, Barcelona, Spain.

The latest progress and future perspectives of thin film photovoltaic kesterite technology are reviewed herein. Kesterite is currently the most promising emerging fully inorganic thin film photovoltaic technology based on critical raw-material-free and sustainable solutions. The positioning of kesterites in the frame of the emerging inorganic solar cells is first addressed, and the recent history of this family of materials briefly described. Read More

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http://dx.doi.org/10.1002/adma.201806692DOI Listing
February 2019

Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue.

Front Physiol 2019 31;10:39. Epub 2019 Jan 31.

Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona, Girona, Spain.

Nrg4 expression has been linked to brown adipose tissue activity and browning of white adipocytes in mice. Here, we aimed to investigate whether these observations could be translated to humans by investigating mRNA and markers of brown/beige adipocytes in human visceral (VAT) and subcutaneous adipose tissue (SAT). We also studied the possible association of with insulin action. Read More

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http://dx.doi.org/10.3389/fphys.2019.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365457PMC
January 2019

Overall Quality of Care Predicts the Variability of Key Risk Factors for Complications in Type 2 Diabetes: An Observational, Longitudinal Retrospective Study.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Objective: An association between variability in clinical parameters (HbA, blood pressure, cholesterol, and uric acid) and risk of complications in type 2 diabetes has been reported. In this analysis, we investigated to what extent such variability is associated with overall quality of care.

Research Design And Methods: The quality of care summary score (Q-score) represents a validated, overall quality of care indicator ranging between 0 and 40; the higher the score, the better the quality of care provided by the diabetes center. Read More

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http://dx.doi.org/10.2337/dc18-1471DOI Listing
February 2019

SALMANTICOR study. Rationale and design of a population-based study to identify structural heart disease abnormalities: a spatial and machine learning analysis.

BMJ Open 2019 Feb 13;9(2):e024605. Epub 2019 Feb 13.

Department of Cardiology, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Facultad de Medicina, Universidad de Salamanca, and CIBERCV, Salamanca, Spain.

Introduction: This study aims to obtain data on the prevalence and incidence of structural heart disease in a population setting and, to analyse and present those data on the application of spatial and machine learning methods that, although known to geography and statistics, need to become used for healthcare research and for political commitment to obtain resources and support effective public health programme implementation.

Methods And Analysis: We will perform a cross-sectional survey of randomly selected residents of Salamanca (Spain). 2400 individuals stratified by age and sex and by place of residence (rural and urban) will be studied. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024605DOI Listing
February 2019

Lung function trajectories in health and disease.

Lancet Respir Med 2019 Feb 11. Epub 2019 Feb 11.

August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona, Spain; Centro de Investigación Biomédica en Red, Enfermedades Respiratorias, Instituto de Salud Carlos III (CIBER), Madrid, Spain.

The normal lung function trajectory from birth to death has three phases: a growth phase (from birth to early adulthood), a plateau phase (that lasts for a few years), and a decline phase resulting from physiological lung ageing. Numerous genetic and environmental factors can alter one or more of these phases. Evidence shows that several lung function trajectories exist throughout the life course and, importantly, that some of them are associated with substantial implications for health and disease. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30529-0DOI Listing
February 2019

Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats.

Int J Food Sci Nutr 2019 Feb 15:1-11. Epub 2019 Feb 15.

c Department of Nutrition, Food Science and Physiology , University of Navarra , Pamplona , Spain.

The aim of this study was to examine the effects of α-lipoic acid (α-LA) on liver mitochondrial bioenergetics and oxidative status for 8 weeks in normal-healthy animals. A pair-fed group was included to differentiate between α-LA direct effects and those changes due to reduced food intake. α-LA decreased body weight gain, liver weight and insulin levels with no differences compared to its pair-fed group. Read More

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http://dx.doi.org/10.1080/09637486.2019.1572716DOI Listing
February 2019

Long-term outcome and psychiatric comorbidity of adolescent-onset anorexia nervosa.

Clin Child Psychol Psychiatry 2019 Feb 15:1359104519827629. Epub 2019 Feb 15.

1 Department of Child and Adolescent Psychiatry and Psychology, 2017SGR881, Institute of Neurosciences, Hospital Clinic de Barcelona, Spain.

Objective:: To assess the outcome of adolescents with anorexia nervosa (AN) about 20 years after first treatment.

Methods:: Sixty-two women diagnosed with AN during adolescence were invited to participate. Of these 62 patients, 38 agreed to participate and were assessed with a battery of questionnaires and interviews. Read More

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http://dx.doi.org/10.1177/1359104519827629DOI Listing
February 2019
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Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2019 Feb 5;11(2). Epub 2019 Feb 5.

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, México/Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, San Fernando No. 22, Col. Sección XVI, Tlalpan, Ciudad de México 14080, México.

Head and neck cancer (HNC) is the sixth cause of cancer-related death worldwide. Head and neck squamous cells carcinoma (HNSCC) is the most frequent subtype of HNC. The development of HNSCC is associated to alcohol consumption, smoking or infection by high-risk human Papillomavirus (HR-HPV). Read More

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http://dx.doi.org/10.3390/cancers11020182DOI Listing
February 2019

Characterization of a mutation in the zona pellucida module of Endoglin that causes hereditary hemorrhagic telangiectasia.

Gene 2019 Feb 11. Epub 2019 Feb 11.

Molecular Medicine Department, General Biology and Medical Genetics Unit, University of Pavia, Via Forlanini 14, 27100 Pavia, Italy. Electronic address:

Hereditary hemorrhagic telangiectasia (HHT) is a vascular rare disease characterized by nose and gastrointestinal bleeding, skin and mucosa telangiectasias, and arteriovenous malformations in internal organs. HHT shows an autosomal dominant inheritance and a worldwide prevalence of approximately 1:5000 individuals. In >80% of patients, HHT is caused by mutations in either ENG (HHT1) or ACVRL1 (HHT2) genes, which code for the membrane proteins Endoglin and Activin A Receptor Type II-Like Kinase 1 (ALK1), respectively, both belonging to the TGF-β/BMP signaling pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193012
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http://dx.doi.org/10.1016/j.gene.2019.02.016DOI Listing
February 2019
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The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair.

PLoS Genet 2019 Feb 14;15(2):e1007971. Epub 2019 Feb 14.

Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.

The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart. Recent findings suggest that WT1 could also be playing physiological roles in adults. Systemic deletion of WT1 in mice provokes a severe deterioration of the exocrine pancreas, with mesothelial disruption, E-cadherin downregulation, disorganization of acinar architecture and accumulation of ascitic transudate. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007971DOI Listing
February 2019

The paradigm of protein acetylation in Parkinson's disease.

Neural Regen Res 2019 Jun;14(6):975-976

Universidad de Extremadura, Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Cáceres; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Spain.

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http://dx.doi.org/10.4103/1673-5374.250575DOI Listing

Endoglin as an Adhesion Molecule in Mature and Progenitor Endothelial Cells: A Function Beyond TGF-β.

Front Med (Lausanne) 2019 30;6:10. Epub 2019 Jan 30.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Endoglin (ENG) is a transmembrane glycoprotein expressed on endothelial cells that functions as a co-receptor for several ligands of the transforming growth factor beta (TGF-β) family. ENG is also a recognized marker of angiogenesis and mutations in the endoglin gene are responsible for Hereditary Hemorrhagic Telangiectasia (HHT) type 1, a vascular disease characterized by defective angiogenesis, arteriovenous malformations, telangiectasia, and epistaxis. In addition to its involvement in the TGF-β family signaling pathways, several lines of evidence suggest that the extracellular domain of ENG has a role in integrin-mediated cell adhesion via its RGD motif. Read More

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http://dx.doi.org/10.3389/fmed.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363663PMC
January 2019

The Secret Life of Translation Initiation in Prostate Cancer.

Front Genet 2019 30;10:14. Epub 2019 Jan 30.

Department of Oncologic Urology, National Institute of Cancer, Mexico City, Mexico.

Prostate cancer (PCa) is the second most prevalent cancer in men worldwide. Despite the advances understanding the molecular processes driving the onset and progression of this disease, as well as the continued implementation of screening programs, PCa still remains a significant cause of morbidity and mortality, in particular in low-income countries. It is only recently that defects of the translation process, i. Read More

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http://dx.doi.org/10.3389/fgene.2019.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363655PMC
January 2019

Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles.

Front Microbiol 2019 30;10:46. Epub 2019 Jan 30.

Departamento de Microbiología, Facultad de Medicina - Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos, Instituto de Investigación Sanitaria Aragón, Universidad de Zaragoza, Zaragoza, Spain.

Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility since they are related with low level resistance to these antibiotics (while high level aminoglycoside resistance is due to mutations in the ribosome). Instead, aminoglycoside acetyltransferases contribute to other bacterial functions, and this can explain its widespread presence along species of genus . Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00046
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http://dx.doi.org/10.3389/fmicb.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363676PMC
January 2019
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Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase.

Front Behav Neurosci 2018 25;12:317. Epub 2019 Jan 25.

Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.

STriatal-Enriched protein tyrosine Phosphatase (STEP) is a neural-specific protein that opposes the development of synaptic strengthening and whose levels are altered in several neurodegenerative and psychiatric disorders. Since STEP is expressed in brain regions implicated in social behavior, namely the striatum, the CA2 region of the hippocampus, cortex and amygdala, here we investigated whether social memory and social patterns were altered in STEP knockout (KO) mice. Our data robustly demonstrated that STEP KO mice presented specific social memory impairment as indicated by the three-chamber sociability test, the social discrimination test, the 11-trial habituation/dishabituation social recognition test, and the novel object recognition test (NORT). Read More

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http://dx.doi.org/10.3389/fnbeh.2018.00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362413PMC
January 2019

Applications of Light-Sheet Microscopy in Microdevices.

Front Neuroanat 2019 25;13. Epub 2019 Jan 25.

Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid, Madrid, Spain.

Light-sheet fluorescence microscopy (LSFM) has been present in cell biology laboratories for quite some time, mainly as custom-made systems, with imaging applications ranging from single cells (in the micrometer scale) to small organisms (in the millimeter scale). Such microscopes distinguish themselves for having very low phototoxicity levels and high spatial and temporal resolution, properties that make them ideal for a large range of applications. These include the study of cellular dynamics, in particular cellular motion which is essential to processes such as tumor metastasis and tissue development. Read More

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https://www.frontiersin.org/article/10.3389/fnana.2019.00001
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http://dx.doi.org/10.3389/fnana.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362405PMC
January 2019
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Ventilation and gas exchange before and after voluntary static surface breath-holds in clinically healthy bottlenose dolphins, .

J Exp Biol 2019 Feb 13. Epub 2019 Feb 13.

Fundación Oceanogràfic de la Comunitat Valenciana, Gran Vía Marqués del Turia 19, 46005 Valencia, Spain.

We measured respiratory flow (), breathing frequency (), tidal volume (), breath durations, and end-expired O content in bottlenose dolphins () before and after static surface breath-holds ranging from 34 to 292 s. There was considerable variation in the end-expired O, tidal volume , and following a breath-hold. The analysis suggests that the dolphins attempt to minimize recovery following a dive by altering , and to rapidly restore the O stores. Read More

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http://dx.doi.org/10.1242/jeb.192211DOI Listing
February 2019

Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors.

Stem Cell Res Ther 2019 Feb 13;10(1):58. Epub 2019 Feb 13.

Hospital Universitario La Paz-IdiPAZ, Paseo de la Castellana 261, 28046, Madrid, Spain.

Background: Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by the inflammatory environment, which changes during tissue repair. Macrophages are essential in mediating the inflammatory response after injury and can adopt a range of functional phenotypes, exhibiting pro-inflammatory and anti-inflammatory activities. An accurate characterization of MSC activation by the inflammatory milieu is needed for improving the efficacy of regenerative therapies. Read More

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http://dx.doi.org/10.1186/s13287-019-1156-6DOI Listing
February 2019

Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.

Eur Heart J Acute Cardiovasc Care 2019 Feb 14:2048872619830609. Epub 2019 Feb 14.

3 Department of Cardiology, Radboud University Medical Center, The Netherlands.

Background:: Conflicting evidence is available on the efficacy and safety of early intravenous beta-blockers before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. We performed a patient-pooled meta-analysis of trials comparing early intravenous beta-blockers with placebo or routine care in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.

Aim:: The aim of this study was to evaluate the clinical and safety outcomes of intravenous beta-blockers in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1177/2048872619830609DOI Listing
February 2019

Lymphoproliferation Impairment and Oxidative Stress in Blood Cells from Early Parkinson's Disease Patients.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

Department of Genetics, Physiology and Microbiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain.

In Parkinson's Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the immune system, based on a chronic-oxidative stress situation, is involved in the rate of aging. We analyzed several functions in isolated peripheral blood neutrophils and mononuclear cells from PD stage 2 patients, and compared the results to those in healthy elderly and adult controls. Read More

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http://dx.doi.org/10.3390/ijms20030771DOI Listing
February 2019