17,881 results match your criteria Biomed Res Int[Journal]


Improving an Intelligent Detection System for Coronary Heart Disease Using a Two-Tier Classifier Ensemble.

Biomed Res Int 2020 27;2020:9816142. Epub 2020 Apr 27.

Department of Mechanical Engineering, Pohang University of Science and Technology, Republic of Korea.

Coronary heart disease (CHD) is one of the severe health issues and is one of the most common types of heart diseases. It is the most frequent cause of mortality across the globe due to the lack of a healthy lifestyle. Owing to the fact that a heart attack occurs without any apparent symptoms, an intelligent detection method is inescapable. Read More

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http://dx.doi.org/10.1155/2020/9816142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201579PMC

The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer.

Biomed Res Int 2020 25;2020:9519235. Epub 2020 Apr 25.

Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.

Liver cancer is a devastating disease for humans with poor prognosis. Although the survival rate of patients with liver cancer has improved in the past decades, the recurrence and metastasis of liver cancer are still obstacles for us. Inositol polyphosphate-5-phosphatase K (INPP5K) belongs to the family of phosphoinositide 5-phosphatases (PI 5-phosphatases), which have been reported to be associated with cell migration, polarity, adhesion, and cell invasion, especially in cancers. Read More

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http://dx.doi.org/10.1155/2020/9519235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201693PMC

Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats.

Biomed Res Int 2020 29;2020:9405909. Epub 2020 Apr 29.

State Key Laboratory of Military Stomatology & National Clinical Research Centre for Oral Diseases & Shaanxi Clinical Research Centre for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, Shaanxi 710032, China.

Osteoporosis is a metabolic disease that results in the progressive loss of bone mass, which, in postmenopausal women, is related to oestrogen deficiency. Periostin (POSTN) plays a key role in the early stages of bone formation. However, whether POSTN participates in oestradiol regulation of osteogenic differentiation of bone marrow stromal cells (BMSCs) from ovariectomised (OVX) rats remains unclear. Read More

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http://dx.doi.org/10.1155/2020/9405909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210524PMC

Correlation between Skip N2 Metastases and SUV, Long Diameter of Tumor, and Ki67 Expression in Patients with Non-Small-Cell Lung Cancer.

Biomed Res Int 2020 25;2020:9298358. Epub 2020 Apr 25.

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China.

Background: We aim at investigating the correlation between skip N2 metastases (SN2) and SUV, long diameter of tumor mass after F-FDG PET/CT, and pathological Ki67 expression in patients with non-small-cell lung cancer (NSCLC).

Methods And Results: We retrospectively analyzed the factors that might affect the pathogenesis of SN2 in these patients. The clinical SN2 symptoms in patients with squamous carcinoma or adenocarcinoma were investigated. Read More

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http://dx.doi.org/10.1155/2020/9298358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201773PMC

Prevalence of Hyperhomocysteinaemia and Associated Factors among Ethiopian Adult Population in a 2015 National Survey.

Biomed Res Int 2020 11;2020:9210261. Epub 2020 Jan 11.

Center for Food Science and Nutrition, College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Hyperhomocysteinaemia (HHcy) is an independent risk factor for major cardiovascular diseases, but data on the prevalence and predictors of HHcy in low- and middle-income countries like Ethiopia are scant. The aim of this study was to estimate the prevalence of HHcy and associated risk factors in the Ethiopian adult population. A cross-sectional survey on risks of noncommunicable diseases (NCDs) using the STEPwise approach to surveillance (STEPS) survey was conducted between April and June 2015. Read More

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http://dx.doi.org/10.1155/2020/9210261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201487PMC
January 2020

Aptamer-Conjugated Multifunctional Polymeric Nanoparticles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems for Treatment of Castration-Resistant Prostate Cancer.

Biomed Res Int 2020 25;2020:9186583. Epub 2020 Apr 25.

Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

Nanoscopic therapeutic systems that incorporate therapeutic agents, molecular targeting, and imaging capabilities have gained momentum and exhibited significant therapeutic potential. In this study, multifunctional polymeric nanoparticles with controlled drug delivery, cancer-targeted capability, and efficient magnetic resonance imaging (MRI) contrast characteristics were formulated and applied in the treatment of castration-resistant prostate cancer (CRPC). The "core-shell" targeted nanoparticles (NPs) were synthesized by the self-assembly of a prefunctionalized amphiphilic triblock copolymer composed of poly(lactic-co-glycolic-acid) (PLGA), polyethylene glycol (PEG), and the Wy5a aptamer (Apt), which have been screened for targeting the CRPC cell line PC-3 by cell-SELEX technique as described in our previous study. Read More

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http://dx.doi.org/10.1155/2020/9186583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201588PMC

A Novel Strategy Facilitates Reference Gene Selection by RT-qPCR Analysis in Kidney Yang Deficiency Syndrome Mice Infected with the Influenza A (H1N1) Virus.

Biomed Res Int 2020 25;2020:9075165. Epub 2020 Apr 25.

Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, China.

In reverse transcription-quantitative polymerase chain reaction (RT-qPCR) studies, endogenous reference genes are routinely used to normalize the expression of target gene studies. In order to precisely evaluate the relative expression of genes in the cells of mice suffering from Kidney Yang Deficiency Syndrome (KYDS) in response to influenza A virus (IAV) H1N1 using RT-qPCR, it is crucial to identify reliable reference genes. In the present study, 15 candidate reference genes (Actb, 2m, Gapdh, Gusb, Tuba, Grcc10, Eif4h, Rnf187, Nedd8, Ywhae, 18S rRNA, Rpl13, Ubc, Rpl32, and Ppia) were investigated in lung cells from KYDS mice infected with IAV H1N1. Read More

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http://dx.doi.org/10.1155/2020/9075165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201461PMC

Comparison of the Superior and Inferior Rectus Muscles in Humans: An Anatomical Study with Notes on Morphology, Anatomical Variations, and Intramuscular Innervation Patterns.

Biomed Res Int 2020 30;2020:9037693. Epub 2020 Apr 30.

Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, USA.

A comparison of the superior and inferior rectus muscles was performed to determine whether they have similar structures and innervation attributable to their participation in the same type of, although antagonistic, eye movements. The study was conducted on 70 cadaveric hemiheads, and the anatomical variations in the superior and inferior rectus muscles were assessed. Sihler's whole mount nerve staining technique was used on 20 isolated superior and 20 isolated inferior rectus muscle specimens to visualize the intramuscular distribution of the oculomotor nerve subbranches. Read More

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http://dx.doi.org/10.1155/2020/9037693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210515PMC

Identification and Analysis of Estrogen Receptor Promoting Tamoxifen Resistance-Related lncRNAs.

Biomed Res Int 2020 28;2020:9031723. Epub 2020 Apr 28.

Department of Microbiome Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

70-75% breast cancer patients are estrogen receptor alpha positive (ER+), and the antiestrogen drug tamoxifen has been used for the past three decades. However, in 20-30% of these patients, tamoxifen therapy fails due to intrinsic or acquired resistance. A previous study has showed ER signaling still exerts significant roles in the development of tamoxifen resistance and several lncRNAs have been demonstrated important roles in tamoxifen resistance. Read More

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http://dx.doi.org/10.1155/2020/9031723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204353PMC

Propofol Attenuates Hypoxia-Induced Inflammation in BV2 Microglia by Inhibiting Oxidative Stress and NF-B/Hif-1 Signaling.

Biomed Res Int 2020 28;2020:8978704. Epub 2020 Apr 28.

Department of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.

Hypoxia-induced neuroinflammation typically causes neurological damage and can occur during stroke, neonatal hypoxic-ischemic encephalopathy, and other diseases. Propofol is widely used as an intravenous anesthetic. Studies have shown that propofol has antineuroinflammatory effect. Read More

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http://dx.doi.org/10.1155/2020/8978704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204316PMC

High Expression of Both Resistin and Fascin-1 Predicts a Poor Prognosis in Patients with Colorectal Cancer.

Biomed Res Int 2020 26;2020:8753175. Epub 2020 Apr 26.

Laboratory of Biomedicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

Emerging evidence indicates that resistin and fascin-1 may possess a causal role in the development of several types of cancers. However, the clinical significance of resistin expression in colorectal cancer (CRC) tissues is unclear, and there are no reports of any correlation between resistin and fascin-1. Our analyses explored the expression of resistin in CRC tissue and analyzed the clinical and prognostic significance of the observed positive correlation between resistin and fascin-1. Read More

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http://dx.doi.org/10.1155/2020/8753175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201636PMC

Skull Sex Estimation Based on Wavelet Transform and Fourier Transform.

Biomed Res Int 2020 11;2020:8608209. Epub 2020 Jan 11.

College of Information Science and Technology, Northwest University, Xi'an, China.

Skull sex estimation is one of the hot research topics in forensic anthropology, and has important research value in the fields of criminal investigation, archeology, anthropology, and so on. Sex estimation of skull is crucial in forensic investigations, whether in legal situations that involve living people or to identify mortal remains. The aim of this study is to establish a skull-based sex estimation model in Chinese population, providing a scientific reference for the practical application of forensic medicine and anthropology. Read More

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http://dx.doi.org/10.1155/2020/8608209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201841PMC
January 2020

and Are Potential Biomarkers for the Diagnosis and Prognosis of Pancreatic Cancer.

Biomed Res Int 2020 28;2020:8604340. Epub 2020 Apr 28.

Lanzhou University, Lanzhou, Gansu Province 730030, China.

Pancreatic cancer (PC) is one of the most malignant tumors. Despite considerable progress in the treatment of PC, the prognosis of patients with PC is poor. The aim of this study was to identify potential biomarkers for the diagnosis and prognosis of PC. Read More

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http://dx.doi.org/10.1155/2020/8604340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206867PMC

Screening and Identification of Differentially Expressed Genes Expressed among Left and Right Colon Adenocarcinoma.

Biomed Res Int 2020 21;2020:8465068. Epub 2020 Jan 21.

Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.

Purpose: Colon adenocarcinoma (COAD) is the third most common malignancy globally and is further categorized as left colon adenocarcinoma (LCOAD) or right colon adenocarcinoma (RCOAD) depending on the location of the primary tumor. The therapeutic outcome and long-term prognosis for patients with COAD are less than satisfactory, and this may be associated with tumor location. Therefore, it is important to investigate the genetic differences in COAD at different sites. Read More

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http://dx.doi.org/10.1155/2020/8465068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201700PMC
January 2020

Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by A and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway.

Biomed Res Int 2020 27;2020:8210578. Epub 2020 Apr 27.

Department of Neurology, Weifang Brain Hospital, Weifang 261021, China.

Objective: This study is aimed at studying the effect of quercetin on the Alzheimer disease cell model induced by A in PC12 cells and its mechanism of action.

Methods: The AD cell model was established by A. Quercetin was used at different concentrations (0, 10, 20, 40, and 80 mol/L). Read More

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http://dx.doi.org/10.1155/2020/8210578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201675PMC

Mir-30b-5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2.

Biomed Res Int 2020 29;2020:7907269. Epub 2020 Apr 29.

Department of Breast and Thyroid Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Triple-negative breast cancer (TNBC) is the most aggressive subtypes of breast cancer, which has few effective targeted therapies. Various sources of evidence confirm that microRNAs (miRNAs) contribute to the progression and metastasis of human breast cancer. However, the molecular mechanisms underlying the changes in miRNAs expression and the regulation of miRNAs functions have not been well clarified. Read More

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http://dx.doi.org/10.1155/2020/7907269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210518PMC

Role of - and -Related Novel Mutations Identified in Patients with FEVR in Norrin/-Catenin Signaling Pathway.

Biomed Res Int 2020 27;2020:7681926. Epub 2020 Apr 27.

Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou 310000, China.

Mutations in and have been closely related to a series of retinal diseases including familial exudative vitreoretinopathy (FEVR). Our study was designed to identify novel and mutations by whole exome sequencing (WES) in a cohort of patients with a definitive diagnosis of FEVR and explore the underlying molecular mechanism. During 2016, we investigated fifty nonconsanguineous families with affected individuals exhibiting FEVR phenotype and WES identified one recently reported mutation: c. Read More

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http://dx.doi.org/10.1155/2020/7681926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201721PMC

Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds.

Biomed Res Int 2020 13;2020:7636290. Epub 2020 Jan 13.

Center of Chemical Engineering, Kazakh-British Technical University, 050000 Almaty, Kazakhstan.

A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil. Read More

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http://dx.doi.org/10.1155/2020/7636290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201524PMC
January 2020

Impacts of Outdoor Air Pollution on Human Semen Quality: A Meta-Analysis and Systematic Review.

Biomed Res Int 2020 28;2020:7528901. Epub 2020 Apr 28.

Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Introduction: Several studies have explored the association between outdoor air pollution and semen quality. However, the results were inconsistent. We performed the current meta-analysis to evaluate the role of outdoor air pollution in semen quality. Read More

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http://dx.doi.org/10.1155/2020/7528901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204269PMC

Identification of Prognostic Immune Genes in Bladder Urothelial Carcinoma.

Biomed Res Int 2020 20;2020:7510120. Epub 2020 Jan 20.

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

Background: The aim of this study is to identify possible prognostic-related immune genes in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these genes.

Methods: The Cancer Genome Atlas (TCGA) expression profile data and corresponding clinical traits were obtained. Differential gene analysis was performed using R software. Read More

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http://dx.doi.org/10.1155/2020/7510120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201587PMC
January 2020

Improvement of Nutritional Status among Tuberculosis Patients by Supplementation: A True Experimental Study in Indonesia.

Biomed Res Int 2020 11;2020:7491702. Epub 2020 Jan 11.

Department of Nutritional Health, School of Public Health, University of Jember, Jember Regency 68121, Indonesia.

Objective: To analyze the effect of supplementation on body mass index among tuberculosis patients, in which their health status is also investigated.

Methods: This study employed a true experiment. The study was designed randomized pretest-posttest with a control group, in which 200 respondents were enrolled. Read More

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http://dx.doi.org/10.1155/2020/7491702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201791PMC
January 2020

Erratic Behavioral Attitude Leads to Noncommunicable Diseases: A Cross-Sectional Study.

Biomed Res Int 2020 10;2020:7257052. Epub 2020 Jan 10.

Department of Public Health, College of Applied Medical Sciences Khamish Mushait, King Khalid University, Abha, Saudi Arabia.

Background: The burden of noncommunicable diseases (NCDs) in the Arab world has reached an alarming level. Behavioral risk factors including consumption of fast food, inadequate sleep, and skipping meals are pervasive. This study aims at establishing the association between NCDs and modernized behavioral risk factors among populations. Read More

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http://dx.doi.org/10.1155/2020/7257052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199604PMC
January 2020

LCZ696, an Angiotensin Receptor-Neprilysin Inhibitor, Improves Cardiac Hypertrophy and Fibrosis and Cardiac Lymphatic Remodeling in Transverse Aortic Constriction Model Mice.

Biomed Res Int 2020 11;2020:7256862. Epub 2020 Jan 11.

Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, No. 68, Changle Road, Nanjing 210006, Jiangsu, China.

Cardiac hypertrophy and ventricular remodeling following heart failure are important causes of high mortality in heart disease patients. The cardiac lymphatic system has been associated with limited research, but it plays an important role in the improvement of myocardial edema and the promotion of fluid balance. LCZ696 is a novel combination of angiotensin and neprilysin inhibitors. Read More

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http://dx.doi.org/10.1155/2020/7256862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201829PMC
January 2020

Improving Efficacy of Endoscopic Diagnosis of Early Gastric Cancer: Gaps to Overcome from the Real-World Practice in Vietnam.

Biomed Res Int 2020 26;2020:7239075. Epub 2020 Apr 26.

Department of Diagnostic Imaging, Saint Paul Hospital, Hanoi, Vietnam.

Objective: To identify factors associated with increased proportion of early gastric cancer to total detected gastric cancer among patients undergoing diagnostic esophagogastroduodenoscopy.

Methods: A nationwide survey was conducted across 6 central-type and 6 municipal-type Vietnamese hospitals. A questionnaire regarding annual esophagogastroduodenoscopy volume, esophagogastroduodenoscopy preparation, the use of image-enhanced endoscopy, and number of gastric cancer diagnosed in 2018 was sent to each hospital. Read More

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http://dx.doi.org/10.1155/2020/7239075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201490PMC

Comparing the Effect of Combining Exercise with Rosuvastatin versus Atorvastatin on Lipid Profile and Functional Capacity: A Retrospective Cohort Study.

Biomed Res Int 2020 29;2020:7026530. Epub 2020 Apr 29.

Centre de Formation Médicale du Nouveau-Brunswick, Moncton, Canada.

Background: Statins and exercise are recommended for managing hypercholesterolemia. However, statin types may vary in their interaction with exercise. We compared rosuvastatin versus atorvastatin combination with exercise on lipid profile and functional capacity. Read More

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http://dx.doi.org/10.1155/2020/7026530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210511PMC

Detection of Diabetic Macular Edema in Optical Coherence Tomography Image Using an Improved Level Set Algorithm.

Biomed Res Int 2020 30;2020:6974215. Epub 2020 Apr 30.

Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200030, China.

Diabetic macular edema (DME) is a major cause of visual loss in the patients with diabetic retinopathy. DME detection in Optical Coherence Tomography (OCT) image contributes to the early diagnosis of diabetic retinopathy and blindness prevention. Currently, DME detection in the OCT image mainly relies on the handwork by the experienced clinician. Read More

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http://dx.doi.org/10.1155/2020/6974215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210525PMC

Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation.

Biomed Res Int 2020 25;2020:6708061. Epub 2020 Apr 25.

Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, Hubei University, Wuhan Hubei 430062, China.

The increased prevalence of nonalcoholic fatty liver disease (NAFLD), which develops from hepatic steatosis, represents a public health challenge. Catalpol, a natural component extracted from the roots of Radix Rehmanniae, has several pharmacological activities. The present study is aimed at examining whether catalpol prevents hepatic steatosis in cell and animal experiments and elucidating the possible mechanisms. Read More

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http://dx.doi.org/10.1155/2020/6708061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201822PMC

Distinguishing Kawasaki Disease from Febrile Infectious Disease Using Gene Pair Signatures.

Biomed Res Int 2020 26;2020:6539398. Epub 2020 Apr 26.

Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No. 9 Jinsui Road, Guangzhou, 510623 Guangdong, China.

Kawasaki disease (KD) is an acute systemic vasculitis of childhood with prolonged fever, and the diagnosis of KD is mainly based on clinical criteria, which is prone to misdiagnosis with other febrile infectious (FI) diseases. Currently, there remain no effective molecular markers for KD diagnosis. In this study, we aimed to use a relative-expression-based method k-TSP and resampling framework to identify robust gene pair signatures to distinguish KD from bacterial and virus febrile infectious diseases. Read More

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http://dx.doi.org/10.1155/2020/6539398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201505PMC

Network Analysis of Transcriptome and LC-MS Reveals a Possible Biosynthesis Pathway of Anthocyanins in .

Biomed Res Int 2020 29;2020:6512895. Epub 2020 Apr 29.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

Anthocyanins, a group of flavonoids, are widely present in plants and determine the colors of the peels of stems, fruits, and flowers. In this study, we used UHPLC-ESI-MS to identify anthocyanins in the herbal plant , which has been used for centuries in China. The results indicated that the total anthocyanin content in samples from Guangxi was the highest. Read More

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http://dx.doi.org/10.1155/2020/6512895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210514PMC

Response to: Comment on "Effective Range of Percutaneous Posterior Full-Endoscopic Paramedian Cervical Disc Herniation Discectomy and Indications for Patient Selection".

Biomed Res Int 2020 23;2020:6387143. Epub 2020 Apr 23.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, 4059 Queensland, Australia.

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http://dx.doi.org/10.1155/2020/6387143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204320PMC

KIR3DL1 and HLA-Bw4 Interaction Showed a Favorable Role in Patients with Myelodysplastic Syndromes in Chinese Southern Han.

Biomed Res Int 2020 29;2020:6215435. Epub 2020 Apr 29.

Immunogenetics Laboratory, Shenzhen Blood Center, Shenzhen, Guangdong 518035, China.

Background: The association studies of killer cell immunoglobulin-like receptors (KIRs) with the occurrence of myelodysplastic syndromes (MDS) are limited worldwide; this study investigated the genetic risk/protective factors of MDS in KIR and human leucocyte antigen (HLA) systems to gain a better understanding of the role played by KIR and their cognate HLA ligands in MDS pathogenesis.

Methods: We genotyped a total number of 77 patients with MDS from Chinese Southern Han and 745 healthy controls for the loci and . The carrier frequencies of genes, genotypes, ligands, and combinations were calculated by direct counting. Read More

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http://dx.doi.org/10.1155/2020/6215435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210520PMC

Resveratrol Attenuates High Glucose-Induced Vascular Endothelial Cell Injury by Activating the E2F3 Pathway.

Biomed Res Int 2020 28;2020:6173618. Epub 2020 Apr 28.

Department of Endocrinology, Shanghai University of Medicine & Health Sciences, Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong New District, Shanghai, China 201318.

Type 2 diabetes mellitus (T2DM) is the most common metabolic disease. High glucose-induced macrovascular disease and microangiopathy are major complications of diabetes. E2F3, a member of the E2F transcription factor family, is closely related to cardiovascular diseases. Read More

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http://dx.doi.org/10.1155/2020/6173618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204347PMC

Factors Associated with Occupational Injury among Hydropower Dam Construction Workers, South East Ethiopia, 2018.

Biomed Res Int 2020 26;2020:6152612. Epub 2020 Apr 26.

Department of Environmental and Occupational Health and Safety, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

Background: Occupational injuries pose a major public health and socioeconomic developmental problems. Globally, 160 million people encounter occupational injuries; the International Labour Organization estimates that the cost is 4 of the global gross domestic product (GDP) or 1.25 trillion United States Dollar (USD). Read More

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http://dx.doi.org/10.1155/2020/6152612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201475PMC

Dynamics of Changes in Isometric Strength and Muscle Imbalance in the Treatment of Women with Low back Pain.

Biomed Res Int 2020 11;2020:6139535. Epub 2020 Jan 11.

Laboratory of Posturology, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.

The aim of the study was to evaluate the dynamics of isometric changes in strength and muscular lumbar-pelvic imbalances in the treatment of women with low back pain. Forty-one women, nineteen in the study group (A) and twenty-two in the control group (B), participated in the study. Magnetic resonance imaging (MRI) was performed to assess the degree of degenerative changes in the lumbar spine. Read More

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http://dx.doi.org/10.1155/2020/6139535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201447PMC
January 2020

Essential Oils of Lemongrass ( Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells.

Biomed Res Int 2020 11;2020:5924856. Epub 2020 Jan 11.

Center for Research and Technology Transfer, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.

Essential oils were extracted from the culm and leaf of collected from different regions of Vietnam and analyzed using GC/MS. The results showed that citral is the major component accounting for 61.20%-76. Read More

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http://dx.doi.org/10.1155/2020/5924856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201560PMC
January 2020

A Review of Computer-Aided Heart Sound Detection Techniques.

Biomed Res Int 2020 10;2020:5846191. Epub 2020 Jan 10.

The First Hospital of Jilin University, Changchun, China.

Cardiovascular diseases have become one of the most prevalent threats to human health throughout the world. As a noninvasive assistant diagnostic tool, the heart sound detection techniques play an important role in the prediction of cardiovascular diseases. In this paper, the latest development of the computer-aided heart sound detection techniques over the last five years has been reviewed. Read More

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http://dx.doi.org/10.1155/2020/5846191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201685PMC
January 2020

RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.

Biomed Res Int 2020 30;2020:5691671. Epub 2020 Apr 30.

Hepatobiliary and Pancreatic Surgery, Shandong Cancer Hospital and Institute, Shandong Fist Medical University and Shandong Academy of Medical Sciences, No. 440 Jiyan Road, Huaiyin District, Jinan City, 250117 Shandong Province, China.

Background: RAB9, as a member of the Rab GTPase family, is required for the transport of the mannose-6-phosphate receptor (MPR) from late endosomes to -Golgi network (TGN). However, the role of RAB9A in tumors, including liver cancer, is still unknown.

Methods: We used pcDNA3. Read More

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http://dx.doi.org/10.1155/2020/5691671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210512PMC

Development of a TaqMan Based Real-Time Fluorescent Quantitative PCR Assay for Detection of Porcine Cytomegalovirus in Semen.

Biomed Res Int 2020 10;2020:5673145. Epub 2020 Jan 10.

Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agriculture Sciences/Fujian Animal Disease Control Technology Development Center, Fuzhou 350013, China.

This study described a TaqMan based real-time fluorescent quantitative PCR (qPCR) method to detect porcine cytomegalovirus (PCMV) infection, targeting the conserved region of the DNA polymerase (DPOL) gene. The standard curve showed a linear regression relationship with a coefficient of 0.999 and a slope of  = -3. Read More

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http://dx.doi.org/10.1155/2020/5673145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199591PMC
January 2020

Effects on Vaginal Microbiota Restoration and Cervical Epithelialization in Positive HPV Patients Undergoing Vaginal Treatment with Carboxy-Methyl-Beta-Glucan.

Biomed Res Int 2020 27;2020:5476389. Epub 2020 Apr 27.

Department of Neurosciences, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Via Sergio Pansini, Naples, Italy.

Objective: Evaluate the effects of carboxy-methyl-beta-glucan on cervical epithelialization and on the vaginal microbiota in patients with HPV infection or low-grade cervical preneoplastic lesion (CIN 1).

Materials And Methods: Seven-hundred eighty-four women with positive HPV tests or diagnosed with CIN 1 were enrolled in a retrospective case-control study. All the recruited women performed, at baseline and after 6 months, Pap test, HPV test, evaluation of vaginal health according to the Amsel criteria, colposcopy, and punch biopsy. Read More

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http://dx.doi.org/10.1155/2020/5476389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201736PMC

Comparison of Cochlear Implant Magnets and Their MRI Artifact Size.

Biomed Res Int 2020 10;2020:5086291. Epub 2020 Jan 10.

Department of Otolaryngology, Head and Neck Surgery, Bielefeld University, Campus Mitte, Bielefeld, Germany.

Introduction: Recent developments regarding cochlear implant magnets (e.g., a bipolar diametral magnet) and refined surgical techniques (e. Read More

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http://dx.doi.org/10.1155/2020/5086291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199598PMC
January 2020

The Prevalence of NAFLD and Fibrosis in Bariatric Surgery Patients and the Reliability of Noninvasive Diagnostic Methods.

Biomed Res Int 2020 26;2020:5023157. Epub 2020 Apr 26.

Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.

Background: Bariatric surgery patients have a higher prevalence of nonalcoholic fatty liver (NAFL) than the general population; however, its assessment and the accurate staging of fibrosis are often complicated because noninvasive tests are not very accurate in patients with morbid obesity, and liver biopsy cannot be performed as a routine exam. The aim of this study was to evaluate (A) the histological prevalence of NAFL, nonalcoholic steatohepatitis (NASH), and fibrosis in patients undergoing bariatric surgery; (B) the reliability of ultrasound (US) in diagnosing NAFL; and (C) the reliability of various fibrosis scoring systems for defining fibrosis.

Methods: US and intraoperative liver biopsy results were reviewed in 57 bariatric surgery patients. Read More

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http://dx.doi.org/10.1155/2020/5023157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201516PMC

Skin Closure Tape and Surgical Staples in Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.

Biomed Res Int 2020 10;2020:4827617. Epub 2020 Jan 10.

Department of Orthopedics, Gansu Provincial Hospital, Donggang West Road, Lanzhou 730000, Gansu, China.

Background: Staples closure technology has been widely used in total knee arthroplasty (TKA) and achieved good results. In recent years, a new type of material called skin closure tape (SCT) has been applied to TKA which also showed good treatment results. However, since it is still not clear yet which one is better, this paper collects literatures for statistical analysis so as to provide evidence for the use of SCT in TKA. Read More

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http://dx.doi.org/10.1155/2020/4827617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199617PMC
January 2020

Fighting Left Handers Promotes Different Visual Perceptual Strategies than Right Handers: The Study of Eye Movements of Foil Fencers in Attack and Defence.

Biomed Res Int 2020 10;2020:4636271. Epub 2020 Jan 10.

Poznań University of Physical Education, Poznań, Poland.

Left handers have long held the edge over right handers in one-on-one interactive combat sports. Particularly in fencing, top rankings show a relatively strong overrepresentation of left handers over right handers. Whether this can be attributed to perceptual strategies used by fencers in their bouts remains to be established. Read More

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http://dx.doi.org/10.1155/2020/4636271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201802PMC
January 2020

Naturally Occurring Microbiota Associated with Mosquito Breeding Habitats and Potential Parasitic Species against Mosquito Larvae: A Study from Gampaha District, Sri Lanka.

Biomed Res Int 2020 28;2020:4602084. Epub 2020 Apr 28.

Department of Zoology and Environmental Management, Faculty of Science, University of Kelaniya, Dalugama, Kelaniya, Sri Lanka GQ 11600.

A mosquito species has its own favourable requirements of abiotic and biotic characteristics including microbiota, in a breeding habitat. Some of the microbiota may cause parasitic or pathogenic effects to mosquito larvae such as species of viruses, parasitic bacteria, fungi, protists, entomopathogenic nematodes, and filamentous fungi. In Sri Lanka, there is a scarcity of information on microbiota associated with mosquito breeding habitats and their effect on mosquito larvae. Read More

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http://dx.doi.org/10.1155/2020/4602084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204370PMC

High Glucose Induces the Loss of Retinal Pericytes Partly via NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis.

Biomed Res Int 2020 23;2020:4510628. Epub 2020 Apr 23.

Department of Rehabilitation, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China 646000.

Diabetic retinopathy (DR) is one of the hallmark complications of diabetes and a leading cause of vision loss in adults. Retinal pericyte death seems to be a prominent feature in the onset of DR. Pyroptosis is an inflammatory form of programmed cell death, defined as being caspase-gasdermin-D (GSDMD)-dependent. Read More

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http://dx.doi.org/10.1155/2020/4510628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201508PMC

Low Medication Knowledge and Adherence to Oral Chronic Medications among Patients Attending Community Pharmacies: A Cross-Sectional Study in a Low-Income Country.

Biomed Res Int 2020 11;2020:4392058. Epub 2020 Jan 11.

Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objective: To investigate the level of knowledge, medication adherence, and the relationship among patients taking chronic oral medication and attending community pharmacies in Gondar, Northwest Ethiopia.

Methods: A cross-sectional study was conducted among adult chronic disease patients who were taking oral medications and getting service in 19 community pharmacies in Gondar City, Northwest Ethiopia. Patients' medication knowledge and adherence were assessed using interviewer-administered validated questionnaires. Read More

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http://dx.doi.org/10.1155/2020/4392058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201603PMC
January 2020

Association between Dietary Vitamin A and HPV Infection in American Women: Data from NHANES 2003-2016.

Biomed Res Int 2020 10;2020:4317610. Epub 2020 Jan 10.

Department of Gynecology, # No. 16 Ji Chang Road, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 510405 Guangzhou City, Guangdong Province, China.

Objective: Evidence regarding the relationship between vitamin A and HPV infection was limited. Therefore, this study is designed to investigate whether vitamin A was independently related to HPV infection in 13412 American women from NHANES for seven cycles.

Methods: The present study is a cross-sectional study. Read More

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http://dx.doi.org/10.1155/2020/4317610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201492PMC
January 2020

Tumor-Suppressive Function of lncRNA-MEG3 in Glioma Cells by Regulating miR-6088/SMARCB1 Axis.

Biomed Res Int 2020 11;2020:4309161. Epub 2020 Jan 11.

Department of Neurosurgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China.

Objective: Mounting evidence has elaborated the implication of long noncoding RNAs (lncRNAs) in tumorigenesis of several cancers, including glioma. However, little was known about the mechanism of lncRNA maternally expressed gene 3 (MEG3) in the development and progression of glioma. This work is designed to explore the effect of MEG3 on glioma progression and its possible mechanism. Read More

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http://dx.doi.org/10.1155/2020/4309161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201742PMC
January 2020

Predictions of Apoptosis Proteins by Integrating Different Features Based on Improving Pseudo-Position-Specific Scoring Matrix.

Biomed Res Int 2020 14;2020:4071508. Epub 2020 Jan 14.

School of Information Science and Engineering, Yunnan University, Kunming 650504, China.

Apoptosis proteins are strongly related to many diseases and play an indispensable role in maintaining the dynamic balance between cell death and division . Obtaining localization information on apoptosis proteins is necessary in understanding their function. To date, few researchers have focused on the problem of apoptosis data imbalance before classification, while this data imbalance is prone to misclassification. Read More

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http://dx.doi.org/10.1155/2020/4071508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201498PMC
January 2020

Machine Learning Supports Long Noncoding RNAs as Expression Markers for Endometrial Carcinoma.

Biomed Res Int 2020 10;2020:3968279. Epub 2020 Jan 10.

Bioinformatics Core, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, Brazil.

Uterine corpus endometrial carcinoma (UCEC) is the second most common type of gynecological tumor. Several research studies have recently shown the potential of different ncRNAs as biomarkers for prognostics and diagnosis in different types of cancers, including UCEC. Thus, we hypothesized that long noncoding RNAs (lncRNAs) could serve as efficient factors to discriminate solid primary (TP) and normal adjacent (NT) tissues in UCEC with high accuracy. Read More

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http://dx.doi.org/10.1155/2020/3968279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199595PMC
January 2020