1,390 results match your criteria Biomechanics and modeling in mechanobiology[Journal]


Glomerular filtration and podocyte tensional homeostasis: importance of the minor type IV collagen network.

Biomech Model Mechanobiol 2020 May 27. Epub 2020 May 27.

Department of Biomedical Engineering, University of Minnesota, 7-105 Nils Hasselmo Hall, 312 Church St SE, Minneapolis, MN, 55455, USA.

The minor type IV collagen chain, which is a significant component of the glomerular basement membrane in healthy individuals, is known to assemble into large structures (supercoils) that may contribute to the mechanical stability of the collagen network and the glomerular basement membrane as a whole. The absence of the minor chain, as in Alport syndrome, leads to glomerular capillary demise and eventually to kidney failure. An important consideration in this problem is that the glomerular capillary wall must be strong enough to withstand the filtration pressure and porous enough to permit filtration at reasonable pressures. Read More

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http://dx.doi.org/10.1007/s10237-020-01347-yDOI Listing

Locomotion of an efficient biomechanical sperm through viscoelastic medium.

Biomech Model Mechanobiol 2020 May 27. Epub 2020 May 27.

School of Mathematics and Statistics, Beijing Institute of Technology, Beijing, 100081, China.

Every group of microorganism utilizes a diverse mechanical strategy to propel through complex environments. These swimming problems deal with the fluid-organism interaction at micro-scales in which Reynolds number is of the order of 10. By adopting the same propulsion mechanism of so-called Taylor's sheet, here we address the biomechanical principle of swimming via different wavy surfaces. Read More

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http://dx.doi.org/10.1007/s10237-020-01338-zDOI Listing

Mechanisms and variances of rotation-induced brain injury: a parametric investigation between head kinematics and brain strain.

Biomech Model Mechanobiol 2020 May 24. Epub 2020 May 24.

Department of Mechanical and Materials Engineering, Faculty of Engineering, Western University, London, ON, N6A 5B9, Canada.

There lacks a comprehensive understanding of the correlation between head kinematics and brain strain especially deep-brain strain, partially resulting the deficiency of understanding brain injury mechanisms and the difficulty of choosing appropriate brain injury metrics. Hence, we simulated 76 impacts that were focused on concussion-relevant rotational kinematics and evaluated cumulative strain damage measure (CSDM) and average strain that could represent brain strain distribution. For the whole brain, axial rotation induced the highest CSDM, while lateral bending produced the lowest CSDM. Read More

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http://dx.doi.org/10.1007/s10237-020-01341-4DOI Listing

Comparing FE human body model rib geometry to population data.

Biomech Model Mechanobiol 2020 May 22. Epub 2020 May 22.

International Center for Automotive Medicine, University of Michigan, Ann Arbor, MI, USA.

Finite element human body models (HBMs) are used to assess injury risk in a variety of impact scenarios. The ribs are a key structural component within the chest, so their accuracy within HBMs is vitally important for modeling human biomechanics. We assessed the geometric correspondence between the ribs defined within five widely used HBMs and measures drawn from population-wide studies of rib geometry, focusing on (1) rib global shape, (2) rib cross-sectional size and shape, and (3) rib cortical bone thickness. Read More

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http://dx.doi.org/10.1007/s10237-020-01335-2DOI Listing

Numerical modeling and verification by nystagmus slow-phase velocity of the function of semicircular canals.

Biomech Model Mechanobiol 2020 May 21. Epub 2020 May 21.

Hearing and Speech Rehabilitation Institute, College of Special Education, Binzhou Medical University, Yantai, 264003, China.

The malfunctioning of semicircular canals (SCCs) in the vestibular system results in diseases that disrupt the individual's daily life. Vestibular diseases can be treated more effectively if the functioning of the SCCs is better understood. However, the SCC is difficult to dissect, because it is a complex structure buried deep in the inner ear. Read More

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http://dx.doi.org/10.1007/s10237-020-01343-2DOI Listing

Numerical investigation of drug delivery by using magnetic field in a 90-degree bent vessel: a 3D simulation.

Biomech Model Mechanobiol 2020 May 16. Epub 2020 May 16.

Department of Mechanical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.

Magnetic drug delivery as a potential method to treat diseases such as cancer tumors has attracted the attention of many researchers. One of the problems in conventional and ineffective therapies is the spread of drug in the circulatory system. The method of magnetic drug delivery aims at directing the drug to the localized area of disease by using a magnetic field. Read More

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http://dx.doi.org/10.1007/s10237-020-01337-0DOI Listing

A viscoelastic two-dimensional network model of the lung extracellular matrix.

Biomech Model Mechanobiol 2020 May 14. Epub 2020 May 14.

Department of Chemical and Materials Engineering, University of Auckland, Auckland, New Zealand.

The extracellular matrix (ECM) comprises a large proportion of the lung parenchymal tissue and is an important contributor to the mechanical properties of the lung. The lung tissue is a biologically active scaffold with a complex ECM matrix structure and composition that provides physical support to the surrounding cells. Nearly all respiratory pathologies result in changes in the structure and composition of the ECM; however, the impact of these alterations on the mechanical properties of the tissue is not well understood. Read More

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http://dx.doi.org/10.1007/s10237-020-01336-1DOI Listing

A comprehensive analysis of bio-inspired design of femoral stem on primary and secondary stabilities using mechanoregulatory algorithm.

Biomech Model Mechanobiol 2020 May 9. Epub 2020 May 9.

School of Mechanical Engineering, Chung-Ang University, 221, Heukseok-Dong, Dongjak-Gu, Seoul, 156-756, Republic of Korea.

The coated porous section of stem surface is initially filled with callus that undergoes osseointegration process, which develops a bond between stem and bone, lessens the micromotions and transfers stresses to the bone, proximally. This phenomenon attributes to primary and secondary stabilities of the stems that exhibit trade-off the stem stiffness. This study attempts to ascertain the influence of stem stiffness on peri-prosthetic bone formation and stress shielding when in silico models of solid CoCr alloy and Ti alloy stems, and porous Ti stems (53. Read More

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http://dx.doi.org/10.1007/s10237-020-01334-3DOI Listing

A two-layer elasto-visco-plastic rheological model for the material parameter identification of bone tissue.

Biomech Model Mechanobiol 2020 May 6. Epub 2020 May 6.

Division Biomechanics, Department of Anatomy and Biomechanics, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria.

The ability to measure bone tissue material properties plays a major role in diagnosis of diseases and material modeling. Bone's response to loading is complex and shows a viscous contribution to stiffness, yield and failure. It is also ductile and damaging and exhibits plastic hardening until failure. Read More

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http://dx.doi.org/10.1007/s10237-020-01329-0DOI Listing

Investigation of interaction phenomena between lower urinary tract and artificial urinary sphincter in consideration of urethral tissues degeneration.

Biomech Model Mechanobiol 2020 May 3. Epub 2020 May 3.

Department of Industrial Engineering, University of Padova, Via Venezia 1, 35131, Padua, Italy.

Lower urinary tract dysfunction pertains to symptoms related to the lower urinary tract (LUT), with consequent incontinence. Artificial urinary sphincters (AUS) are adopted to obtain continence conditions, mainly in male subjects, via urethral occlusion by applying pressure load, mostly operating on the basis of an empirical approach. Considering the frequent access of elderly patients to this surgical practice, tissue degradation related to aging phenomena must be investigated. Read More

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http://dx.doi.org/10.1007/s10237-020-01326-3DOI Listing

Biomechanical properties of the rat sclera obtained with inverse finite element modeling.

Biomech Model Mechanobiol 2020 May 2. Epub 2020 May 2.

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, 2116 IBB, Atlanta, GA, 30332, USA.

It is widely accepted that biomechanics plays an important role in glaucoma pathophysiology, but the mechanisms involved are largely unknown. Rats are a common animal model of glaucoma, and finite element models are being developed to provide much-needed insight into the biomechanical environment of the posterior rat eye. However, material properties of rat ocular tissues, including the sclera, are currently unknown. Read More

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http://dx.doi.org/10.1007/s10237-020-01333-4DOI Listing

Stimulus-effect relations for left ventricular growth obtained with a simple multi-scale model: the influence of hemodynamic feedback.

Biomech Model Mechanobiol 2020 May 1. Epub 2020 May 1.

Technische Universiteit Eindhoven, PO Box 513, 5600 MB, Eindhoven, The Netherlands.

Cardiac growth is an important mechanism for the human body to respond to changes in blood flow demand. Being able to predict the development of chronic growth is clinically relevant, but so far models to predict growth have not reached consensus on the stimulus-effect relation. In a previously published study, we modeled cardiac and hemodynamic function through a lumped parameter approach. Read More

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http://dx.doi.org/10.1007/s10237-020-01327-2DOI Listing

On the mechanical response of the actomyosin cortex during cell indentations.

Biomech Model Mechanobiol 2020 Apr 30. Epub 2020 Apr 30.

Mechanical Engineering Department, Faculty of Engineering, Porto, Portugal.

A mechanical model is presented to analyze the mechanics and dynamics of the cell cortex during indentation. We investigate the impact of active contraction on the cross-linked actin network for different probe sizes and indentation rates. The essential molecular mechanisms of filament stretching, cross-linking and motor activity, are represented by an active and viscous mechanical continuum. Read More

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http://dx.doi.org/10.1007/s10237-020-01324-5DOI Listing

Force-dependent recruitment from myosin OFF-state increases end-systolic pressure-volume relationship in left ventricle.

Biomech Model Mechanobiol 2020 Apr 28. Epub 2020 Apr 28.

Department of Mechanical Engineering, University of Kentucky, 269 Ralph G. Anderson Building, Lexington, KY, 40506-0503, USA.

Finite element (FE) modeling is becoming increasingly prevalent in the world of cardiac mechanics; however, many existing FE models are phenomenological and thus do not capture cellular-level mechanics. This work implements a cellular-level contraction scheme into an existing nonlinear FE code to model ventricular contraction. Specifically, this contraction model incorporates three myosin states: OFF-, ON-, and an attached force-generating state. Read More

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http://dx.doi.org/10.1007/s10237-020-01331-6DOI Listing

Outbreak dynamics of COVID-19 in China and the United States.

Biomech Model Mechanobiol 2020 Apr 27. Epub 2020 Apr 27.

Departments of Mechanical Engineering and Bioengineering, Stanford University, Stanford, CA, USA.

On March 11, 2020, the World Health Organization declared the coronavirus disease 2019, COVID-19, a global pandemic. In an unprecedented collective effort, massive amounts of data are now being collected worldwide to estimate the immediate and long-term impact of this pandemic on the health system and the global economy. However, the precise timeline of the disease, its transmissibility, and the effect of mitigation strategies remain incompletely understood. Read More

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http://dx.doi.org/10.1007/s10237-020-01332-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185268PMC

Fluidity and elasticity form a concise set of viscoelastic biomarkers for breast cancer diagnosis based on Kelvin-Voigt fractional derivative modeling.

Biomech Model Mechanobiol 2020 Apr 25. Epub 2020 Apr 25.

Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Cancer progression involves biomechanical changes within transformed cells and the surrounding extracellular matrix (ECM). The viscoelastic features of fluidity and elasticity that are based on a novel Kelvin-Voigt fractional derivative (KVFD) model were found capable of discriminating normal, benign and malignant breast biopsy tissues on the cellular scale. The improved specificity of KVFD model parameters derives from greater accuracy of fitting the entire approaching force-indentation measurement curve ([Formula: see text] > 0. Read More

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http://dx.doi.org/10.1007/s10237-020-01330-7DOI Listing

An efficient two-scale 3D FE model of the bone fibril array: comparison of anisotropic elastic properties with analytical methods and micro-sample testing.

Biomech Model Mechanobiol 2020 Apr 24. Epub 2020 Apr 24.

ARTORG Centre for Biomedical Engineering Research, University of Bern, Bern, Switzerland.

In this study, 3D finite element analyses (FEA) are conducted to quantify the orthotropic elastic properties and investigate the load transfer mechanism of bone at the sub-lamellar level. Three finite element (FE) unit cells with periodic boundary conditions are presented to model a two-scale microstructure of bone including a mineralized collagen fibril (MCF), the extrafibrillar matrix (EFM) and the resulting fibril array (FAY) under arbitrary loading. The axial and transverse elastic properties of the FAY computed by FEA are calibrated with unique experimental results on ovine micro-samples showing a coherent fibril orientation. Read More

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http://dx.doi.org/10.1007/s10237-020-01328-1DOI Listing

Loads distributed in vivo among vertebrae, muscles, spinal ligaments, and intervertebral discs in a passively flexed lumbar spine.

Biomech Model Mechanobiol 2020 Apr 20. Epub 2020 Apr 20.

Computational Biophysics and Biorobotics, Institute for Modelling and Simulation of Biomechanical Systems, Stuttgart Center for Simulation Science (SimTech), Universität Stuttgart, Nobelstraße 15, 70569, Stuttgart, Germany.

The load distribution among lumbar spinal structures-still an unanswered question-has been in the focus of this hybrid experimental and simulation study. First, the overall passive resistive torque-angle characteristics of healthy subjects' lumbar spines during flexion-extension cycles in the sagittal plane were determined experimentally by use of a custom-made trunk-bending machine. Second, a forward dynamic computer model of the human body that incorporates a detailed lumbar spine was used to (1) simulate the human-machine interaction in accordance with the experiments and (2) validate the modeled properties of the load-bearing structures. Read More

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http://dx.doi.org/10.1007/s10237-020-01322-7DOI Listing

Modelling secondary lymphatic valves with a flexible vessel wall: how geometry and material properties combine to provide function.

Authors:
C D Bertram

Biomech Model Mechanobiol 2020 Apr 18. Epub 2020 Apr 18.

School of Mathematics and Statistics, University of Sydney, Sydney, NSW, 2006, Australia.

A three-dimensional finite-element fluid/structure interaction model of an intravascular lymphatic valve was constructed, and its properties were investigated under both favourable and adverse pressure differences, simulating valve opening and valve closure, respectively. The shear modulus of the neo-Hookean material of both vascular wall and valve leaflet was varied, as was the degree of valve opening at rest. Also investigated was how the valve characteristics were affected by prior application of pressure inflating the whole valve. Read More

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http://dx.doi.org/10.1007/s10237-020-01325-4DOI Listing

Effects of a novel medial meniscus implant on the knee compartments: imaging and biomechanical aspects.

Biomech Model Mechanobiol 2020 Mar 31. Epub 2020 Mar 31.

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, 6997801, Tel Aviv, Israel.

The altered biomechanical function of the knee following partial meniscectomy results in ongoing articular cartilage overload, which may lead to progressive osteoarthritis (OA). An artificial medial meniscus implant (NUsurface Meniscus Implant, Active Implants LLC., Memphis, TN, USA) was developed to mimic the native meniscus and may provide an effective long-term solution for OA patients, alleviate pain, and restore joint function. Read More

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http://dx.doi.org/10.1007/s10237-020-01323-6DOI Listing

Longitudinal computational fluid dynamics study of stenosis and aneurysmal degeneration of an aortorenal bypass.

Biomech Model Mechanobiol 2020 Mar 21. Epub 2020 Mar 21.

Department of Applied Mechanics, Sichuan University, Chengdu, 610065, People's Republic of China.

Saphenous vein graft (SVG) bypass placement is regarded as the optimal option for renal artery stenosis, which usually causes secondary hypertension and poor renal perfusion. Using computational fluid dynamics, this study aimed to investigate the underlying hemodynamic mechanism of the vein aneurysm and stenosis after aortorenal bypass surgery. Three-dimensional models were reconstructed based on computed tomographic angiography images of a 20-year-old female patient who suffered from uncontrollable hypertension using the image processing package Mimics (Materialise). Read More

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http://dx.doi.org/10.1007/s10237-020-01320-9DOI Listing

A hybrid model of intercellular tension and cell-matrix mechanical interactions in a multicellular geometry.

Biomech Model Mechanobiol 2020 Mar 20. Epub 2020 Mar 20.

Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.

Epithelial cells form continuous sheets of cells that exist in tensional homeostasis. Homeostasis is maintained through cell-to-cell junctions that distribute tension and balance forces between cells and their underlying matrix. Disruption of tensional homeostasis can lead to epithelial-mesenchymal transition (EMT), a transdifferentiation process in which epithelial cells adopt a mesenchymal phenotype, losing cell-cell adhesion and enhancing cellular motility. Read More

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http://dx.doi.org/10.1007/s10237-020-01321-8DOI Listing

Computational modeling of drug transport and mixing in the chemofilter device: enhancing the removal of chemotherapeutics from circulation.

Biomech Model Mechanobiol 2020 Mar 12. Epub 2020 Mar 12.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.

Intra-arterial chemotherapy (IAC) is the preferred treatment for non-resectable hepatocellular carcinoma. A large fraction of IAC drugs, e.g. Read More

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http://dx.doi.org/10.1007/s10237-020-01313-8DOI Listing

Experimental and analytical study of anisotropic strength properties of bovine cortical bone.

Biomech Model Mechanobiol 2020 Mar 10. Epub 2020 Mar 10.

McMaster University, Hamilton, ON, Canada.

This paper is focused on specification of conditions at failure in bovine cortical bone. Both experimental and analytical studies are conducted. The experimental part includes a series of novel direct shear tests which examine the sensitivity of shear strength to the applied normal stress for different orientations of the sample microstructure. Read More

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http://dx.doi.org/10.1007/s10237-020-01319-2DOI Listing

An adaptive finite element model for steerable needles.

Biomech Model Mechanobiol 2020 Mar 9. Epub 2020 Mar 9.

Department of Mechanical Engineering Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Penetration of a flexible and steerable needle into a soft target material is a complex problem to be modelled, involving several mechanical challenges. In the present paper, an adaptive finite element algorithm is developed to simulate the penetration of a steerable needle in brain-like gelatine material, where the penetration path is not predetermined. The geometry of the needle tip induces asymmetric tractions along the tool-substrate frictional interfaces, generating a bending action on the needle in addition to combined normal and shear loading in the region where fracture takes place during penetration. Read More

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http://dx.doi.org/10.1007/s10237-020-01310-xDOI Listing

Calibration of hyperelastic constitutive models: the role of boundary conditions, search algorithms, and experimental variability.

Biomech Model Mechanobiol 2020 Mar 5. Epub 2020 Mar 5.

Department of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH, 45221-0072, USA.

The calibration of hyperelastic constitutive models of soft tissue and tissue surrogates is often treated as an exercise in curve-fitting to the average experimental response, and many of the complicating factors such as experimental boundary conditions and data variability are ignored. In this work, we focus on three questions that arise in this area: the ramifications of ignoring the experimental boundary conditions, the use of local optimizers, and the role of data variability. Using data from a uniaxial extension experiment on a tissue surrogate, we study how these three factors affect the calibration of isotropic hyperelastic constitutive models. Read More

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http://dx.doi.org/10.1007/s10237-020-01318-3DOI Listing

Evaluation of injury thresholds for predicting severe head injuries in vulnerable road users resulting from ground impact via detailed accident reconstructions.

Biomech Model Mechanobiol 2020 Mar 4. Epub 2020 Mar 4.

Chalmers University of Technology, 412 96, Gothenburg, Sweden.

The aim of this study was to evaluate the effectiveness of various head injury criteria and associated risk functions in prediction of vulnerable road users (VRUs) severe head injuries caused by ground impact during vehicle collisions. Ten VRU accidents with video information were reconstructed by using Chalmers Pedestrian Model, vehicle multi-body system models and the THUMS (Ver. 4. Read More

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http://dx.doi.org/10.1007/s10237-020-01312-9DOI Listing

Spatiotemporal remodeling of embryonic aortic arch: stress distribution, microstructure, and vascular growth in silico.

Biomech Model Mechanobiol 2020 Mar 4. Epub 2020 Mar 4.

Department of Mechanical Engineering, Koc University, Rumeli Feneri Kampüsü, Sariyer, Istanbul, Turkey.

The microstructure for mature vessels has been investigated in detail, while there is limited information about the embryonic stages, in spite of their importance in the prognosis of congenital heart defects. It is hypothesized that the embryonic vasculature represents a disorganized but dynamic soft tissue, which rapidly evolves toward a specialized multi-cellular vascular structure under mechanical loading. Here the microstructural evolution process of the embryonic pharyngeal aortic arch structure was simulated using an in ovo validated long-term growth and remodeling computational model, implemented as an in-house FEBio plug-in. Read More

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http://dx.doi.org/10.1007/s10237-020-01315-6DOI Listing

Heat transfer analysis of peristaltic flow of a Phan-Thien-Tanner fluid model due to metachronal wave of cilia.

Biomech Model Mechanobiol 2020 Mar 3. Epub 2020 Mar 3.

Department of Mathematics and Statistics, Riphah International University, I-14, Islamabad, Pakistan.

In the present investigation, we have studied the effects of heat transfer on the peristaltic flow considering the Phan-Thien-Tanner fluid model. The fluid is flowing in a uniform circular tube in the form of wave motion. The inner walls of the tube are considered to be ciliated with small hair-like structures. Read More

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http://dx.doi.org/10.1007/s10237-020-01317-4DOI Listing

Signalling molecule transport analysis in lacunar-canalicular system.

Biomech Model Mechanobiol 2020 Feb 28. Epub 2020 Feb 28.

Department of Mechanical Engineering, Manipal University Jaipur, Jaipur, Rajasthan, 303007, India.

Mechanical loading-induced fluid flow in lacunar-canalicular space (LCS) of bone excites osteocyte cells to release signalling molecules which initiate osteo-activities. Theoretical models considered canaliculi as a uniform and symmetrical space/channel in bone. However, experimental studies reported that canalicular walls are irregular and curvy resulting in inhomogeneous fluid motion which may influence the molecular transport. Read More

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http://dx.doi.org/10.1007/s10237-020-01314-7DOI Listing
February 2020

Cell-substrate mechanics guide collective cell migration through intercellular adhesion: a dynamic finite element cellular model.

Biomech Model Mechanobiol 2020 Feb 27. Epub 2020 Feb 27.

Department of Bioengineering, University of Illinois at Chicago, Chicago, USA.

During the process of tissue formation and regeneration, cells migrate collectively while remaining connected through intercellular adhesions. However, the roles of cell-substrate and cell-cell mechanical interactions in regulating collective cell migration are still unclear. In this study, we employ a newly developed finite element cellular model to study collective cell migration by exploring the effects of mechanical feedback between cell and substrate and mechanical signal transmission between adjacent cells. Read More

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http://dx.doi.org/10.1007/s10237-020-01308-5DOI Listing
February 2020

Length scale parameter of single trabecula in cancellous bone.

Biomech Model Mechanobiol 2020 Feb 27. Epub 2020 Feb 27.

School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran.

In this paper, the material length scale parameter of the modified couple stress theory for trabecular bones is studied. For this reason, experimental data for the buckling of single wet and dry trabeculae from the subchondral region of the human medial tibial plateau are used from the literature. A material length scale parameter is extracted using the modified couple stress theory-based buckling relation and the experimental results. Read More

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http://dx.doi.org/10.1007/s10237-020-01316-5DOI Listing
February 2020

Study of the combined effects of PTH treatment and mechanical loading in postmenopausal osteoporosis using a new mechanistic PK-PD model.

Biomech Model Mechanobiol 2020 Feb 25. Epub 2020 Feb 25.

Biomechanics and Spine Research Group, Queensland University of Technology, Brisbane, QLD, Australia.

One of only a few approved and available anabolic treatments for severe osteoporosis is daily injections of PTH (1-34). This drug has a specific dual action which can act either anabolically or catabolically depending on the type of administration, i.e. Read More

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http://dx.doi.org/10.1007/s10237-020-01307-6DOI Listing
February 2020

Deformation behaviour of stomatocyte, discocyte and echinocyte red blood cell morphologies during optical tweezers stretching.

Biomech Model Mechanobiol 2020 Feb 25. Epub 2020 Feb 25.

School of Mechanical, Medical and Process Engineering, Science and Engineering Faculty, Queensland University of Technology (QUT), Brisbane, QLD, Australia.

The red blood cell (RBC) deformability is a critical aspect, and assessing the cell deformation characteristics is essential for better diagnostics of healthy and deteriorating RBCs. There is a need to explore the connection between the cell deformation characteristics, cell morphology, disease states, storage lesion and cell shape-transformation conditions for better diagnostics and treatments. A numerical approach inspired from the previous research for RBC morphology predictions and for analysis of RBC deformations is proposed for the first time, to investigate the deformation characteristics of different RBC morphologies. Read More

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http://dx.doi.org/10.1007/s10237-020-01311-wDOI Listing
February 2020

Numerical evaluation of transcatheter aortic valve performance during heart beating and its post-deployment fluid-structure interaction analysis.

Biomech Model Mechanobiol 2020 Feb 24. Epub 2020 Feb 24.

Department of Biomedical Engineering, Health Sciences Center T08-050, Stony Brook University, Stony Brook, NY, 11794-8084, USA.

Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure that provides an effective alternative to open-heart surgical valve replacement for treating advanced calcific aortic valve disease patients. However, complications, such as valve durability, device migration, paravalvular leakage (PVL), and thrombogenicity may lead to increased overall post-TAVR morbidity and mortality. A series of numerical studies involving a self-expandable TAVR valve were performed to evaluate these complications. Read More

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http://dx.doi.org/10.1007/s10237-020-01304-9DOI Listing
February 2020

Experimental and numerical study on the mechanical properties of cortical and spongy cranial bone of 8-week-old porcines at different strain rates.

Biomech Model Mechanobiol 2020 Feb 21. Epub 2020 Feb 21.

School of Mechanical, Electronic and Control Engineering, Beijing Jiaotong University, Beijing, 100044, China.

Pediatric porcines have widely been used as substitute for children in biomechanical research. Previous studies have used entire piglet cranium when testing their properties. Here, the piglet craniums from the frontal and parietal locations were carefully dissected into spongy and cortical part, and tensile tests at different strain rates were then conducted on these two bone types. Read More

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http://dx.doi.org/10.1007/s10237-020-01309-4DOI Listing
February 2020

Interaction of ultrasound waves with bone remodelling: a multiscale computational study.

Biomech Model Mechanobiol 2020 Feb 20. Epub 2020 Feb 20.

Aix-Marseille Univ, CNRS, Centrale Marseille, IRPHE, Marseille, France.

Ultrasound stimulation is thought to influence bone remodelling process. But recently, the efficiency of ultrasound therapy for bone healing has been questioned. Despite an extensive literature describing the positive effect of ultrasound on bone regeneration-cell cultures, animal models, clinical studies-there are more and more reviews denouncing the inefficiency of clinical devices based on low-intensity pulsed ultrasound stimulation (LIPUS) of the bone healing. Read More

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http://dx.doi.org/10.1007/s10237-020-01306-7DOI Listing
February 2020

Correction to: A computational model of a network of initial lymphatics and pre-collectors with permeable interstitium.

Biomech Model Mechanobiol 2020 04;19(2):677-679

School of Mathematics and Statistics, University of Sydney, Sydney, NSW, Australia.

In the published paper, we argued that, although there appear to be no data available on the subject, it is inherently unlikely that lymph having traversed a network of initial lymphatics and pre-collectors then encounters an abrupt transition to vessels with all of the typical properties of collecting lymphatics. Read More

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http://dx.doi.org/10.1007/s10237-020-01303-wDOI Listing

Pressure overload changes mesenteric afferent nerve responses in a stress-dependent way in a fasting rat model.

Biomech Model Mechanobiol 2020 Feb 18. Epub 2020 Feb 18.

GIOME and the Key Laboratory for Biorheological Science and Technology of Ministry of Education; State and Local Joint Engineering Laboratory for Vascular Implants, College of Bioengineering, Chongqing University, Chongqing, 400044, China.

It is well known that overload changes the mechanical properties of biological tissues and fasting changes the responsiveness of intestinal afferents. This study aimed to characterize the effect of overload on mechanosensitivity in mesenteric afferent nerves in normal and fasted Sprague-Dawley rats. Food was restricted for 7 days in the Fasting group. Read More

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http://dx.doi.org/10.1007/s10237-020-01305-8DOI Listing
February 2020

A shear-rate-dependent flow generated via magnetically controlled metachronal motion of artificial cilia.

Biomech Model Mechanobiol 2020 Feb 13. Epub 2020 Feb 13.

School of Mathematics and Statistics, Beijing Institute of Technology, Beijing, 100081, China.

Cilia beating is a naturally occurring phenomenon that can be utilized in fluid transport in designing several biomechanical devices. Inspired by the ubiquity of bio-fluids (which are non-Newtonian), we report the characteristics of shear-rate-dependent viscosities on fluid flow generated by the wavy propulsion of magnetic cilia. We assume that the metachronal waves of these cilia form a two-dimensional wavy channel, which is filled with generalized Newtonian Carreau liquid. Read More

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http://dx.doi.org/10.1007/s10237-020-01301-yDOI Listing
February 2020

Nonlinear viscoelastic constitutive model for bovine liver tissue.

Biomech Model Mechanobiol 2020 Feb 10. Epub 2020 Feb 10.

Division of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Soft tissue mechanical characterisation is important in many areas of medical research. Examples span from surgery training, device design and testing, sudden injury and disease diagnosis. The liver is of particular interest, as it is the most commonly injured organ in frontal and side motor vehicle crashes, and also assessed for inflammation and fibrosis in chronic liver diseases. Read More

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http://dx.doi.org/10.1007/s10237-020-01297-5DOI Listing
February 2020

Vital erythrocyte phenomena: what can theory, modeling, and simulation offer?

Biomech Model Mechanobiol 2020 Feb 10. Epub 2020 Feb 10.

Department of Structural Engineering, University of California, San Diego, USA.

We overview recent advances in the theoretical modeling, in particular via numerical simulation, of various vital human erythrocyte phenomena. The review is novel in how it interconnects a range of analysis within a coherent framework and focuses on extracting from them specific suggestions for experimental studies focused on, either validation of the analysis' mechanistic basis, or uncovering heretofore unrecognized effects and mechanistic understanding. In some cases, new analysis is described to fill in gaps and expand on previously published findings. Read More

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http://dx.doi.org/10.1007/s10237-020-01302-xDOI Listing
February 2020

On the anatomical definition of arterial networks in blood flow simulations: comparison of detailed and simplified models.

Biomech Model Mechanobiol 2020 Feb 8. Epub 2020 Feb 8.

Laboratório Nacional de Computação Científica, Av. Getúlio Vargas 333, Petrópolis, 25651-075, Brazil.

The goal of this work is to assess the impact of vascular anatomy definition degree in the predictions of blood flow models of the arterial network. To this end, results obtained with an anatomically detailed network containing over 2000 vessels are systematically compared with those obtained with an anatomically simplified network containing the main 86 vessels, the latter being a truncated version of the former one. The comparison is performed quantitatively and qualitatively in terms of pressure and flow rate waveforms, wave intensity analysis and impedance analysis. Read More

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http://dx.doi.org/10.1007/s10237-020-01298-4DOI Listing
February 2020

Investigation of inhalation and exhalation flow pattern in a realistic human upper airway model by PIV experiments and CFD simulations.

Biomech Model Mechanobiol 2020 Feb 5. Epub 2020 Feb 5.

Hefei Institute for Public Safety Research, Tsinghua University, Hefei, 320601, Anhui Province, China.

In this study, flow field characteristics in the trachea region in a realistic human upper airway model were firstly measured by particle image velocimetry (PIV) in the air under three constant inhalation and exhalation conditions: 36 L/min, 64 L/min and 90 L/min, representing flow rates of 18 L/min, 32 L/min and 45 L/min in real human airway (the model was twice the size of a human airway). Computational fluid dynamics (CFD) analyses were performed on four turbulence models, with boundary conditions corresponding to the PIV experiments. The effects of flow rates and breathing modes on the airflow patterns were investigated. Read More

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http://dx.doi.org/10.1007/s10237-020-01299-3DOI Listing
February 2020

Computational framework for population-based evaluation of TKR-implanted patellofemoral joint mechanics.

Biomech Model Mechanobiol 2020 Feb 4. Epub 2020 Feb 4.

Center for Orthopaedic Biomechanics, Mechanical and Materials Engineering, University of Denver, 2155 E Wesley Ave, Denver, CO, 80208, USA.

Differences in patient anatomy are known to influence joint mechanics. Accordingly, intersubject anatomical variation is an important consideration when assessing the design of joint replacement implants. The objective of this study was to develop a computational workflow to perform population-based evaluations of total knee replacement implant mechanics considering variation in patient anatomy and to assess the potential for an efficient sampling strategy to support design phase screening analyses. Read More

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http://dx.doi.org/10.1007/s10237-020-01295-7DOI Listing
February 2020

Prediction of stenosis behaviour in artery by neural network and multiple linear regressions.

Biomech Model Mechanobiol 2020 Feb 3. Epub 2020 Feb 3.

Mathematics and Its Applications in Life Sciences Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Blood flow analysis in the artery is a paramount study in the field of arterial stenosis evaluation. Studies conducted so far have reported the analysis of blood flow parameters using different techniques, but the regression analysis is not adequately used. Artificial neural network is a nonlinear and nonparametric approach. Read More

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http://dx.doi.org/10.1007/s10237-020-01300-zDOI Listing
February 2020

A mechanobiological model to study upstream cell migration guided by tensotaxis.

Biomech Model Mechanobiol 2020 Jan 31. Epub 2020 Jan 31.

Institute of Science and Technology, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Brazil.

Cell migration is a process of crucial importance for the human body. It is responsible for important processes such as wound healing and tumor metastasis. Migration may occur in response to stimuli of chemical, physical and mechanical nature occurring in the cellular microenvironment. Read More

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http://dx.doi.org/10.1007/s10237-020-01289-5DOI Listing
January 2020

Tissue-engineered multi-cellular models of the uterine wall.

Biomech Model Mechanobiol 2020 Jan 29. Epub 2020 Jan 29.

Gynecological Oncology Unit, Lis Maternity Hospital, Tel-Aviv Medical Center, 64239, Tel-Aviv, Israel.

The human uterus is composed of three layers: endometrium, myometrium and perimetrium. It remodels during the monthly menstrual cycle and more significantly during the complex stages of reproduction. In vivo studies of the human uterine wall are yet incomplete due to ethical and technical limitations. Read More

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http://dx.doi.org/10.1007/s10237-020-01296-6DOI Listing
January 2020

To lead or to herd: optimal strategies for 3D collective migration of cell clusters.

Biomech Model Mechanobiol 2020 Jan 29. Epub 2020 Jan 29.

Mechanical Engineering Department, San Diego State University, San Diego, USA.

Cells migrating in clusters play a significant role in a number of biological processes such as embryogenesis, wound healing, and tumor metastasis during cancer progression. A variety of environmental and biochemical factors can influence the collective migration of cells with differing degrees of cell autonomy and inter-cellular coupling strength. For example, weakly coupled cells can move collectively under the influence of contact guidance from neighboring cells or the environment. Read More

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http://dx.doi.org/10.1007/s10237-020-01290-yDOI Listing
January 2020

Fluid-structure interaction simulations of patient-specific aortic dissection.

Biomech Model Mechanobiol 2020 Jan 28. Epub 2020 Jan 28.

3D and Quantitative Imaging Laboratory, Department of Radiology, Stanford University, Stanford, CA, 94305, USA.

Credible computational fluid dynamic (CFD) simulations of aortic dissection are challenging, because the defining parallel flow channels-the true and the false lumen-are separated from each other by a more or less mobile dissection membrane, which is made up of a delaminated portion of the elastic aortic wall. We present a comprehensive numerical framework for CFD simulations of aortic dissection, which captures the complex interplay between physiologic deformation, flow, pressures, and time-averaged wall shear stress (TAWSS) in a patient-specific model. Our numerical model includes (1) two-way fluid-structure interaction (FSI) to describe the dynamic deformation of the vessel wall and dissection flap; (2) prestress and (3) external tissue support of the structural domain to avoid unphysiologic dilation of the aortic wall and stretching of the dissection flap; (4) tethering of the aorta by intercostal and lumbar arteries to restrict translatory motion of the aorta; and a (5) independently defined elastic modulus for the dissection flap and the outer vessel wall to account for their different material properties. Read More

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http://dx.doi.org/10.1007/s10237-020-01294-8DOI Listing
January 2020