111 results match your criteria Biomatter[Journal]


Fabrication and surface modification of poly lactic acid (PLA) scaffolds with epidermal growth factor for neural tissue engineering.

Biomatter 2016 01 14;6(1):e1231276. Epub 2016 Oct 14.

a Department of Chemical Engineering , École Polytechnique de Montréal , Centre-Ville, Montréal ( QC ), Canada.

In an effort to design biomaterials that may promote repair of the central nervous system, 3-dimensional scaffolds made of electrospun poly lactic acid nanofibers with interconnected pores were fabricated. These scaffolds were functionalized with polyallylamine to introduce amine groups by wet chemistry. Experimental conditions of the amination protocol were thoroughly studied and selected to introduce a high amount of amine group while preserving the mechanical and structural properties of the scaffold. Read More

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http://dx.doi.org/10.1080/21592535.2016.1231276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098722PMC
January 2016
28 Reads

Enhanced bioactivity of glass ionomer cement by incorporating calcium silicates.

Biomatter 2016 ;6:e1123842

a Applied Materials Science, Department of Engineering Science, Uppsala University , Uppsala , Sweden.

Glass ionomer cements (GIC) are known as a non-bioactive dental cement. During setting the GIC have an acidic pH, driven by the acrylic acid component. It is a challenge to make GIC alkaline without disturbing its mechanical properties. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055208PMC
http://dx.doi.org/10.1080/21592535.2015.1123842DOI Listing
December 2016
4 Reads

The effect of oligo(trimethylene carbonate) addition on the stiffness of acrylic bone cement.

Biomatter 2016 ;6:e1133394

a Div. of Applied Materials Science, Dept. Engineering Sciences, Uppsala University , Uppsala , Sweden.

With the increasing elderly population an increase in the number of bony fractures associated to age-related diseases such as osteoporosis also follows. The relatively high stiffness of the acrylic bone cements used in these patients has been suggested to give raise to a suboptimal load distribution surrounding the cement in vivo, and hence contribute to clinical complications, such as additional fractures. The aim of this study was to develop a low-modulus bone cement, based on currently used, commercially available poly(methyl methacrylate) (PMMA) cements for vertebroplasty. Read More

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http://dx.doi.org/10.1080/21592535.2015.1133394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927199PMC
December 2016
8 Reads

Corrigendum.

Authors:
February 2016

Strontium ranelate improves the interaction of osteoblastic cells with titanium substrates: Increase in cell proliferation, differentiation and matrix mineralization.

Biomatter 2015 ;5:e1027847

a Institut de Sciences des Matériaux de Mulhouse; CNRS UMR7361; Université de Haute-Alsace ; Mulhouse , France.

We describe direct effects of strontium ranelate on the interaction of osteoblastic cells with different titanium substrates. Our goal was to better understand the potential of this drug for improving the efficacy of bone implants. Treatment was done with 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044704PMC
http://dx.doi.org/10.1080/21592535.2015.1027847DOI Listing
September 2016
1 Read

Small-sized granules of biphasic bone substitutes support fast implant bed vascularization.

Biomatter 2015 ;5:e1056943

a Institute of Pathology; Repair-Lab ; University Medical Center of the Johannes Gutenberg University ; Mainz , Germany.

The present study investigated the influence of granule size of 2 biphasic bone substitutes (BoneCeramic® 400-700 μm and 500-1000 μm) on the induction of multinucleated giant cells (MNGCs) and implant bed vascularization in a subcutaneous implantation model in rats. Furthermore, degradation mechanisms and particle phagocytosis of both materials were examined by transmission electron microscopy (TEM). Both granule types induced tissue reactions involving primarily mononuclear cells and only small numbers of MNGCs. Read More

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http://dx.doi.org/10.1080/21592535.2015.1056943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581126PMC
December 2015

Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain.

Biomatter 2015 ;5:e1005527

a Center for Biotechnology and Interdisciplinary Studies; Department of Biomedical Engineering ; Rensselaer Polytechnic Institute ; Troy , NY USA.

Tissue engineering scaffolds are often designed without appropriate consideration for the translational potential of the material. Solid scaffolds implanted into central nervous system (CNS) tissue to promote regeneration may require tissue resection to accommodate implantation. Or alternatively, the solid scaffold may be cut or shaped to better fit an irregular injury geometry, but some features of the augmented scaffold may fail to integreate with surrounding tissue reducing regeneration potential. Read More

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https://www.tandfonline.com/doi/full/10.1080/21592535.2015.1
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http://dx.doi.org/10.1080/21592535.2015.1005527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581123PMC
December 2015
7 Reads

Development of a novel carrier optimized for cell sheet transplantation.

Biomatter 2015 ;5:e1027846

a Cooperative Major in Advanced Health Science; Graduate School of Bio-Applications and System Engineering; Laboratories of.

Tissue engineering is a rapidly advancing technology in the field of regenerative medicine. For the transplantation of cell sheets, a carrier must maintain the shape of a cell sheet from a culture dish to affected sites as well as release the sheet easily onto the lesion. In this study, we examined the utility of a novel, poly(lactic acid)-based carrier for cell sheets transplantation to the cornea of dogs and the skin of rats. Read More

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http://dx.doi.org/10.1080/21592535.2015.1027846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581122PMC
December 2015
4 Reads

On the potential for fibronectin/phosphorylcholine coatings on PTFE substrates to jointly modulate endothelial cell adhesion and hemocompatibility properties.

Biomatter 2015 ;5:e979679

a Laboratory for Biomaterials & Bioengineering (CRC-I); Department of Min-Met-Materials Engineering & CHU de Quebec Research Center; Laval University ; Quebec City , Canada.

The use of biomolecules as coatings on biomaterials is recognized to constitute a promising approach to modulate the biological response of the host. In this work, we propose a coating composed by 2 biomolecules susceptible to provide complementary properties for cardiovascular applications: fibronectin (FN) to enhance endothelialization, and phosphorylcholine (PRC) for its non thrombogenic properties. Polytetrafluoroethylene (PTFE) was selected as model substrate mainly because it is largely used in cardiovascular applications. Read More

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https://www.tandfonline.com/doi/full/10.4161/21592535.2014.9
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http://dx.doi.org/10.4161/21592535.2014.979679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581125PMC
December 2015
2 Reads

A brief review of mathematical models of thin film growth and surfaces. A possible route to avoid defects in stents.

Biomatter 2014 ;4:e28871

a Federal University of Amazonas (UFAM); Amazonas, Brazil.

The morphology of thin films has been extensively studied in the last years. The properties of a thin film are closely related to its microstructure, especially to its morphology and surface roughness. Optical reflectivity, conductivity, and porosity are characteristics that depend on the film structure. Read More

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http://dx.doi.org/10.4161/biom.28871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122570PMC

Nanotemplated polyelectrolyte films as porous biomolecular delivery systems. Application to the growth factor BMP-2.

Biomatter 2014 ;4:e28823

a Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules; Institut des Matériaux; Université de Cergy-Pontoise; Cergy-Pontoise, France.

Biomaterials capable of delivering controlled quantities of bioactive agents, while maintaining mechanical integrity, are needed for a variety of cell contacting applications. We describe here a nanotemplating strategy toward porous, polyelectrolyte-based thin films capable of controlled biomolecular loading and release. Films are formed via the layer-by-layer assembly of charged polymers and nanoparticles (NP), then chemically cross-linked to increase mechanical rigidity and stability, and finally exposed to tetrahydrofuran to dissolve the NP and create an intra-film porous network. Read More

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http://dx.doi.org/10.4161/biom.28823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122565PMC

Platinum metallization for MEMS application. Focus on coating adhesion for biomedical applications.

Biomatter 2014 ;4:e28822

a Fondazione Bruno Kessler (FBK); Povo di Trento, Italy.

The adherence of Platinum thin film on Si/SiO2 wafer was studies using Chromium, Titanium or Alumina (Cr, Ti, Al2O3) as interlayer. The adhesion of Pt is a fundamental property in different areas, for example in MEMS devices, which operate at high temperature conditions, as well as in biomedical applications, where the problem of adhesion of a Pt film to the substrate is known as a major challenge in several industrial applications health and in biomedical devices, such as for example in the stents. We investigated the properties of Chromium, Titanium, and Alumina (Cr, Ti, and Al2O3) used as adhesion layers of Platinum (Pt) electrode. Read More

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http://dx.doi.org/10.4161/biom.28822DOI Listing
August 2015
2 Reads

Dextran grafting on PTFE surface for cardiovascular applications.

Biomatter 2014 ;4:e28805

a Laboratory for Biomaterials & Bioengineering (CRC-I); Dept Min-Met-Materials Eng. & CHU de Quebec Research Center; Laval University; Quebec City, QC Canada.

The modification of biomaterial surfaces with biomolecules influences the biological response. In this work, caboxymethyldextrans (CMD) with different degrees of substitution have been grafted to surfaces by introduction of amino moieties directly onto the substrate surface. Polytetrafluoroethylene was selected as a model substrate for biomaterial as it is already largely used for cardiovascular clinical applications. Read More

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http://dx.doi.org/10.4161/biom.28805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122567PMC
August 2015
3 Reads

Poly(vinyl alcohol) hydrogel coatings with tunable surface exposure of hydroxyapatite.

Biomatter 2014 ;4:e28764

a Centre des Matériaux; UMR 7633 Mines-ParisTech; Evry, France.

Insufficient bone anchoring is a major limitation of artificial substitutes for connective osteoarticular tissues. The use of coatings containing osseoconductive ceramic particles is one of the actively explored strategies to improve osseointegration and strengthen the bone-implant interface for general tissue engineering. Our hypothesis is that hydroxyapatite (HA) particles can be coated robustly on specific assemblies of PVA hydrogel fibers for the potential anchoring of ligament replacements. Read More

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http://dx.doi.org/10.4161/biom.28764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122568PMC
August 2015
4 Reads

The effects of a SiO2 coating on the corrosion parameters cpTi and Ti-6Al-7Nb alloy.

Biomatter 2014 ;4:e28535

a Department of Biomaterials and Medical Engineering Devices; Silesian University of Technology; Zabrze, Poland.

The aim of this paper was to evaluate the usefulness of the sol-gel method application, to modificate the surface of the Ti6Al7Nb alloy and the cpTi titanium (Grade 4) with SiO2 oxide, applied on the vascular implants to improve their hemocompatibility. Mechanical treatment was followed by film deposition on surface of the titanium samples. An appropriate selection of the process parameters was verified in the studies of corrosion, using potentiodynamic and impedance method. Read More

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http://dx.doi.org/10.4161/biom.28535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122566PMC
August 2015
3 Reads

Influence of ECAP process on mechanical and corrosion properties of pure Mg and ZK60 magnesium alloy for biodegradable stent applications.

Biomatter 2014 ;4:e28283

a Department of Mechanical Engineering; Politecnico di Milano; Milan, Italy.

Equal channel angular pressing (ECAP) was performed on ZK60 alloy and pure Mg in the temperature range 150-250 °C. A significant grain refinement was detected after ECAP, leading to an ultrafine grain size (UFG) and enhanced formability during extrusion process. Comparing to conventional coarse grained samples, fracture elongation of pure Mg and ZK60 alloy were significantly improved by 130% and 100%, respectively, while the tensile strength remained at high level. Read More

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http://dx.doi.org/10.4161/biom.28283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122571PMC
August 2015
49 Reads

Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer models.

Biomatter 2014 ;4:e955386

a Department of Pathology and Diagnostics ; University of Verona ; Verona , Italy.

We analyzed the interactions between human primary cells from pancreatic ductal adenocarcinoma (PDAC) and polymeric scaffolds to develop 3D cancer models useful for mimicking the biology of this tumor. Three scaffold types based on two biocompatible polymeric formulations, such as poly(vinyl alcohol)/gelatin (PVA/G) mixture and poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) copolymer, were obtained via different techniques, namely, emulsion and freeze-drying, compression molding followed by salt leaching, and electrospinning. In this way, primary PDAC cells interfaced with different pore topographies, such as sponge-like pores of different shape and size or nanofiber interspaces. Read More

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http://dx.doi.org/10.4161/21592527.2014.955386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578550PMC
August 2015
19 Reads

Effect of grain sizes on mechanical properties and biodegradation behavior of pure iron for cardiovascular stent application.

Biomatter 2016 ;6:e959874

b Laboratory for Biomaterials and Bioengineering (CRC-I), Department of Materials Engineering & CHU de Quebec Research Centre, Laval University , Quebec City , Canada.

Pure iron has been demonstrated as a potential candidate for biodegradable metal stents due to its appropriate biocompatibility, suitable mechanical properties and uniform biodegradation behavior. The competing parameters that control the safety and the performance of BMS include proper strength-ductility combination, biocompatibility along with matching rate of corrosion with healing rate of arteries. Being a micrometre-scale biomedical device, the mentioned variables have been found to be governed by the average grain size of the bulk material. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055204PMC
http://dx.doi.org/10.4161/21592527.2014.959874DOI Listing
December 2016
4 Reads
2 Citations

Comparison of the reaction of bone-derived cells to enhanced MgCl2-salt concentrations.

Biomatter 2014 ;4:e967616

a Helmholtz-Zentrum Geesthacht; Institute of Materials Research; Structural Research on Macromolecules ; Geesthacht , Germany.

Magnesium-based implants exhibit various advantages such as biodegradability and potential for enhanced in vivo bone formation. However, the cellular mechanisms behind this possible osteoconductivity remain unclear. To determine whether high local magnesium concentrations can be osteoconductive and exclude other environmental factors that occur during the degradation of magnesium implants, magnesium salt (MgCl2) was used as a model system. Read More

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http://dx.doi.org/10.4161/21592527.2014.967616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578555PMC
August 2015
3 Reads

Design of 2D chitosan scaffolds via electrochemical structuring.

Biomatter 2014 18;4. Epub 2014 Jun 18.

Politecnico di Milano; Department of Chemistry, Materials, and Chemical Engineering; Milan, Italy; INSTM - Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali; Local Unit Politecnico di Milano; Milan, Italy.

Chitosan (CS) is a versatile biopolymer whose morphological and chemico-physical properties can be designed for a variety of biomedical applications. Taking advantage of its electrolytic nature, cathodic polarization allows CS deposition on electrically conductive substrates, resulting in thin porous structures with tunable morphology. Here we propose an easy method to obtain CS membranes with highly oriented micro-channels for tissue engineering applications, relying on simple control of process parameters and cathodic substrate geometry. Read More

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http://dx.doi.org/10.4161/biom.29506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138223PMC
January 2015
6 Reads

Properties of titanium-alloyed DLC layers for medical applications.

Biomatter 2014 5;4. Epub 2014 Aug 5.

Masaryk University; Faculty of Medicine; Brno, Czech Republic.

DLC-type layers offer a good potential for application in medicine, due to their excellent tribological properties, chemical resistance, and bio-inert character. The presented study has verified the possibility of alloying DLC layers with titanium, with coatings containing three levels of titanium concentration prepared. Titanium was present on the surface mainly in the form of oxides. Read More

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http://dx.doi.org/10.4161/biom.29505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138222PMC
January 2015
1 Read

Novel hybrid membrane of chitosan/poly (ε-caprolactone) for tissue engineering.

Biomatter 2014 5;4. Epub 2014 Aug 5.

University of Campinas; Materials Engineering Department; Campinas, Brazil; Biofabris; Campinas, Brazil.

We investigated the potential use of 3D hybrid membrane: poly (ε-caprolactone) (PCL) mesh using rotary jet spinning with subsequent chitosan (CH) coating. The morphological examinations by scanning electron microscopy (SEM) were proved the efficiency of this technique on obtaining relative homogeneous PCL fiber mats (15,49±4,1µm), with high surface porosity (1,06±0,41µm) and effective CH coating. The feasibility of rotary jet spinning allowed the solvent evaporation during the process; this fact was verified by differential scanning calorimetry (DSC), indeed also had verified changes in thermal properties on the hybrid membrane, since the present of CH. Read More

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http://www.tandfonline.com/doi/abs/10.4161/biom.29508
Publisher Site
http://dx.doi.org/10.4161/biom.29508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143402PMC
January 2015
3 Reads

Magnetic force microscopy: quantitative issues in biomaterials.

Biomatter 2014 22;4. Epub 2014 Jul 22.

Department of Basic and Applied Sciences for Engineering; University of Rome Sapienza; Rome, Italy; Centro di Ricerca per le Nanotecnologie Applicate all'Ingegneria della Sapienza (CNIS); University of Rome Sapienza; Rome, Italy.

Magnetic force microscopy (MFM) is an atomic force microscopy (AFM) based technique in which an AFM tip with a magnetic coating is used to probe local magnetic fields with the typical AFM spatial resolution, thus allowing one to acquire images reflecting the local magnetic properties of the samples at the nanoscale. Being a well established tool for the characterization of magnetic recording media, superconductors and magnetic nanomaterials, MFM is finding constantly increasing application in the study of magnetic properties of materials and systems of biological and biomedical interest. After reviewing these latter applications, three case studies are presented in which MFM is used to characterize: (i) magnetoferritin synthesized using apoferritin as molecular reactor; (ii) magnetic nanoparticles loaded niosomes to be used as nanocarriers for drug delivery; (iii) leukemic cells labeled using folic acid-coated core-shell superparamagnetic nanoparticles in order to exploit the presence of folate receptors on the cell membrane surface. Read More

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http://dx.doi.org/10.4161/biom.29507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145005PMC
January 2015
9 Reads

Platinum metallization for MEMS application: focus on coating adhesion for biomedical applications.

Biomatter 2014 ;4

UFSC, Federal University of S. Catarina; Florianopolis, Brazil.

The adherence of Platinum thin film on Si/SiO 2 wafer was studies using Chromium, Titanium or Alumina (Cr, Ti, Al 2O 3) as interlayer. The adhesion of Pt is a fundamental property in different areas, for example in MEMS devices, which operate at high temperature conditions, as well as in biomedical applications, where the problem of adhesion of a Pt film to the substrate is known as a major challenge in several industrial applications health and in biomedical devices, such as for example in the stents. (1)(-) (4) We investigated the properties of Chromium, Titanium, and Alumina (Cr, Ti, and Al 2O 3) used as adhesion layers of Platinum (Pt) electrode. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122564PMC
January 2015

The role of dialysis and freezing on structural conformation, thermal properties and morphology of silk fibroin hydrogels.

Biomatter 2014 19;4:e28536. Epub 2014 Mar 19.

Instituto de Engenharia Biomédica; Universidade do Porto; Porto, Portugal; Centro de Estudos em Biomedicina; Universidade Fernando Pessoa; Porto, Portugal.

Silk fibroin has been widely explored for many biomedical applications, due to its biocompatibility and biodegradability. The aim of this work was to study the role of dialysis and freezing on structural conformation, thermal properties and morphology of silk fibroin hydrogels. Hydrogels were prepared after 3 and 7 days of dialysis and the effect of freezing was analyzed. Read More

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http://dx.doi.org/10.4161/biom.28536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014454PMC
January 2015
16 Reads

Nanocarbon surfaces for biomedicine.

Biomatter 2014 19;4:e28537. Epub 2014 Mar 19.

Electron Microscopies and Nanoscopies (EMiNa) Lab; Department of Basic and Applied Sciences for Engineering; Sapienza Nanotechnologies and Nanosciences (SNN) Lab; CNIS; Università di Roma Sapienza; Roma Italy.

The distinctive physicochemical, mechanical and electrical properties of carbon nanostructures are currently gaining the interest of researchers working in bioengineering and biomedical fields. Carbon nanotubes, carbon dendrimers, graphenic platelets and nanodiamonds are deeply studied aiming at their application in several areas of biology and medicine.   Here we provide a summary of the carbon nanomaterials prepared in our labs and of the fabrication techniques used to produce several biomedical utilities, from scaffolds for tissue growth to cargos for drug delivery and to biosensors. Read More

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http://dx.doi.org/10.4161/biom.28537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091123PMC
January 2015
5 Reads

Alternative technique for calcium phosphate coating on titanium alloy implants.

Biomatter 2014 19;4:e28534. Epub 2014 Mar 19.

Institut de Physique et Chimie des Matériaux de Strasbourg CNRS-UMR 7504; Strasbourg, France.

As an alternative technique for calcium phosphate coating on titanium alloys, we propose to functionalize the metal surface with anionic bath containing chlorides of palladium or silver as activators. This new deposition route has several advantages such as controlled conditions, applicability to complex shapes, no adverse effect of heating, and cost effectiveness. A mixture of hydroxyapatite and calcium phosphate hydrate is deposited on the surface of Ti-6Al-4V. Read More

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http://dx.doi.org/10.4161/biom.28534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010538PMC
January 2015
10 Reads

Characterization of a bioactive fiber scaffold with entrapped HUVECs in coaxial electrospun core-shell fiber.

Biomatter 2014 19;4:e28238. Epub 2014 Feb 19.

School of Materials and Science Engineering; Division of Materials Technology; Nanyang Technological University; Singapore.

Human umbilical vein endothelial cells (HUVECs) were successfully entrapped in polyethylene oxide (PEO) core /polycaprolactone (PCL) shell electrospun fibers thus creating a "bioactive fiber." The viability and release of biomolecules from the entrapped cells in the bioactive fibers were characterized. A key modification to the core solution was the inclusion of 50% fetal bovine serum (FBS), which improved cell viability substantially. Read More

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http://dx.doi.org/10.4161/biom.28238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976980PMC
January 2015
13 Reads

Water uptake and swelling in single trabeculæ from human femur head.

Biomatter 2014 19;4:e28237. Epub 2014 Feb 19.

Orthopedy and Traumatology Area; Campus Bio-Medico University; Rome, Italy.

The swelling of air-dried single trabeculae from human femur heads was obtained by complete immersion in water and the dimensional changes of the samples were measured over time. The experimental results were analyzed under the viewpoint of the diffusion through a porous material. The dimensional changes of the single trabeculae were 0. Read More

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http://dx.doi.org/10.4161/biom.28237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091056PMC
January 2015
2 Reads

Grafting of a model protein on lactide and caprolactone based biodegradable films for biomedical applications.

Biomatter 2014 6;4:e27979. Epub 2014 Feb 6.

Department of Mining-Metallurgy Engineering and Materials Science; POLYMAT; University of the Basque Country (UPV/EHU); School of Engineering; Bilbao, Spain.

Thermoplastic biodegradable polymers displaying elastomeric behavior and mechanical consistency are greatly appreciated for the regeneration of soft tissues and for various medical devices. However, while the selection of a suitable base material is determined by mechanical and biodegradation considerations, it is the surface properties of the biomaterial that are responsible for the biological response. In order to improve the interaction with cells and modulate their behavior, biologically active molecules can be incorporated onto the surface of the material. Read More

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http://dx.doi.org/10.4161/biom.27979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014455PMC
January 2015
3 Reads

Comprehensive histological evaluation of bone implants.

Biomatter 2014 6;4. Epub 2014 Feb 6.

Department of Trauma and Reconstructive Surgery; University Hospital Carl Gustav Carus; Technische Universität Dresden; Dresden, Germany; University Hospital and Medical Faculty; Technische Universität Dresden; Centre for Translational Bone, Joint and Soft Tissue Research; Dresden, Germany.

To investigate and assess bone regeneration in sheep in combination with new implant materials classical histological staining methods as well as immunohistochemistry may provide additional information to standard radiographs or computer tomography. Available published data of bone defect regenerations in sheep often present none or sparely labeled histological images. Repeatedly, the exact location of the sample remains unclear, detail enlargements are missing and the labeling of different tissues or cells is absent. Read More

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http://dx.doi.org/10.4161/biom.27993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979890PMC
January 2015
6 Reads

Biocompatibility and characterization of a Kolsterised(®) medical grade cobalt-chromium-molybdenum alloy.

Biomatter 2014 17;4:e27713. Epub 2014 Jan 17.

Department of Metallurgy and Materials Engineering; University of Malta; Msida, Malta.

High failure rates of cobalt-chromium-molybdenum (Co-Cr-Mo) metal-on-metal hip prosthesis were reported by various authors, probably due to the alloy's limited hardness and tribological properties. This thus caused the popularity of the alloy in metal-on-metal hip replacements to decrease due to its poor wear properties when compared with other systems such as ceramic-on-ceramic. S-phase surface engineering has become an industry standard when citing surface hardening of austenitic stainless steels. Read More

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http://dx.doi.org/10.4161/biom.27713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958430PMC
January 2015
15 Reads

In vitro and in vivo bioactivity assessment of a polylactic acid/hydroxyapatite composite for bone regeneration.

Biomatter 2014 17;4:e27664. Epub 2014 Jan 17.

Department of Tissue Regeneration; University of Twente; Enschede, The Netherlands.

Synthetic bone graft substitutes based on composites consisting of a polymer and a calcium-phosphate (CaP) ceramic are developed with the aim to satisfy both mechanical and bioactivity requirements for successful bone regeneration. In the present study, we have employed extrusion to produce a composite consisting of 50 wt.% poly(D,L-lactic acid) (PLA) and 50 wt. Read More

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http://www.tandfonline.com/doi/abs/10.4161/biom.27664
Publisher Site
http://dx.doi.org/10.4161/biom.27664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961484PMC
January 2015
24 Reads

The mineralized collagen for the reconstruction of intra-articular calcaneal fractures with trabecular defects.

Biomatter 2013 Oct-Dec;3(4). Epub 2013 Nov 22.

Tongji Hospital; Tongji Medical College; Huazhong University of Science and Technology; Wuhan, PR China.

Background: In cases of severe subversion of the morphology of calcaneal fractures with trabecular defects, bone graft is often necessary to provide a mechanical buttress. The mineralized collagen (MC) is a novel bone substitute that is developed by biomimetic synthesis strategy that mimics the extracellular matrix (ECM) of natural bone in structure and chemical composition. It can avoid donor site morbidity and complications associated with harvesting autologous bone graft. Read More

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http://dx.doi.org/10.4161/biom.27250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903599PMC
November 2014
2 Reads

Influence of polymer addition on the mechanical properties of a premixed calcium phosphate cement.

Biomatter 2013 Oct-Dec;3(4). Epub 2013 Nov 22.

Division of Applied Materials Science; Department of Engineering Sciences; Uppsala University; Uppsala, Sweden.

Premixed calcium phosphate cements can reduce handling complications that are associated with the mixing of cements in the operating room. However, to extend the clinical indication of ceramic cements their mechanical properties need to be further improved. The incorporation of a polymeric material with intrinsically high tensile properties could possibly assist in increasing the mechanical properties of calcium phosphate cement. Read More

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http://dx.doi.org/10.4161/biom.27249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891756PMC
November 2014
4 Reads

Synergetic inactivation of Staphylococcus epidermidis and Streptococcus mutansin a TiO2/H2O2/UV system.

Biomatter 2013 Oct-Dec;3(4). Epub 2013 Oct 17.

Division of Nanotechnology and Functional Materials; Department of Engineering Sciences; The Ångström Laboratory; Uppsala University; Uppsala, Sweden.

TiO 2 photocatalysis can be used to kill surface adherent bacteria on biomaterials, and is particularly interesting for use with percutaneous implants and devices. Its efficiency and safety, however, depend on the activation energy required. This in vitro study investigates synergetic effects against the clinically relevant strains S. Read More

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http://dx.doi.org/10.4161/biom.26727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866197PMC
November 2014
2 Reads

Strength retention behavior of oriented PLLA, 96L/4D PLA, and 80L/20D,L PLA.

Biomatter 2013 Oct-Dec;3(4). Epub 2013 Sep 11.

BioMediTech; Tampere, Finland; Department of Electronics and Communications Engineering; Tampere University of Technology; Tampere, Finland.

The strength retention characteristics of oriented semicrystalline polylactides were monitored during hydrolytic degradation in vitro. The effects of the polymer type, the material's initial inherent viscosity (iv), the sample diameter and the residual monomer content on strength retention were analyzed. The analyzed polylactides had similar, but not identical, strength retention characteristics. Read More

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http://dx.doi.org/10.4161/biom.26395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825234PMC
November 2014
2 Reads

Plasma functionalization of poly(vinyl alcohol) hydrogel for cell adhesion enhancement.

Biomatter 2013 Oct-Dec;3(4). Epub 2013 Jul 29.

Inserm, U698; Cardiovascular Bio-Engineering; X. BichatHospital; Paris, France.

Tailoring the interface interactions between a biomaterial and the surrounding tissue is a capital aspect to consider for the design of medical devices. Poly(vinyl alcohol) (PVA) hydrogels present suitable mechanical properties for various biological substitutes, however the lack of cell adhesion on their surface is often a problem. The common approach is to incorporate biomolecules, either by blending or coupling. Read More

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http://www.tandfonline.com/doi/abs/10.4161/biom.25414
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http://dx.doi.org/10.4161/biom.25414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825233PMC
November 2014
17 Reads

Biomaterials and bioengineering tomorrow's healthcare.

Biomatter 2013 Jul-Sep;3(3). Epub 2013 Jul 24.

BioPhysics Group; UCL Institute of Biomedical Engineering; UCL Centre for Stem Cells and Regenerative Medicine; Department of Mechanical Engineering; University College London; London, UK.

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http://dx.doi.org/10.4161/biom.25887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749285PMC
December 2014

Polymer-conjugated inhibitors of tumor necrosis factor-α for local control of inflammation.

Biomatter 2013 Jul-Sep;3(3). Epub 2013 Jul 10.

Department of Biomedical Engineering; Carnegie Mellon University; Pittsburgh, PA USA.

Burns, chronic wounds, osteoarthritis, and uveitis are examples of conditions characterized by local, intense inflammatory responses that can impede healing or even further tissue degradation. The most powerful anti-inflammatory drugs available are often administered systemically, but these carry significant side effects and are not compatible for patients that have underlying complications associated with their condition. Conjugation of monoclonal antibodies that neutralize pro-inflammatory cytokines to high molecular weight hydrophilic polymers has been shown to be an effective strategy for local control of inflammation. Read More

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http://dx.doi.org/10.4161/biom.25597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749284PMC
December 2014
1 Read

Mechanical and biocompatible characterization of a cross-linked collagen-hyaluronic acid wound dressing.

Biomatter 2013 Oct-Dec;3(4). Epub 2013 Jul 29.

Research and Development Department; Nanotherapeutics, Inc.; Alachua, FL USA.

Collagen scaffolds have been widely employed as a dermal equivalent to induce fibroblast infiltrations and dermal regeneration in the treatment of chronic wounds and diabetic foot ulcers. Cross-linking methods have been developed to address the disadvantages of the rapid degradation associated with collagen-based scaffolds. To eliminate the potential drawbacks associated with glutaraldehyde cross-linking, methods using a water soluble carbodiimide have been developed. Read More

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http://www.tandfonline.com/doi/abs/10.4161/biom.25633
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http://dx.doi.org/10.4161/biom.25633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866196PMC
November 2014
9 Reads

Cytotoxicity of cultured macrophages exposed to antimicrobial zinc oxide (ZnO) coatings on nanoporous aluminum oxide membranes.

Biomatter 2013 Jul-Sep;3(3). Epub 2013 Jun 25.

Joint Department of Biomedical Engineering; UNC-Chapel Hill and North Carolina State University; Raleigh, NC USA.

Zinc oxide (ZnO) is a widely used commercial material that is finding use in wound healing applications due to its antimicrobial properties. Our study demonstrates a novel approach for coating ZnO with precise thickness control onto 20 nm and 100 nm pore diameter anodized aluminum oxide using atomic layer deposition (ALD). ZnO was deposited throughout the nanoporous structure of the anodized aluminum oxide membranes. Read More

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http://dx.doi.org/10.4161/biom.25528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749283PMC
December 2014
13 Reads

Mechanical models for the self-organization of tubular patterns.

Authors:
Chin-Lin Guo

Biomatter 2013 Jul-Sep;3(3). Epub 2013 May 21.

Department of Bioengineering; California Institute of Technology; Pasadena, CA USA.

Organogenesis, such as long tubule self-organization, requires long-range coordination of cell mechanics to arrange cell positions and to remodel the extracellular matrix. While the current mainstream in the field of tissue morphogenesis focuses primarily on genetics and chemical signaling, the influence of cell mechanics on the programming of patterning cues in tissue morphogenesis has not been adequately addressed. Here, we review experimental evidence and propose quantitative mechanical models by which cells can create tubular patterns. Read More

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http://dx.doi.org/10.4161/biom.24926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749282PMC
December 2014
4 Reads

Role of culture conditions on in vitro transformation and cellular colonization of biomimetic HA-Col scaffolds.

Biomatter 2013 Apr-Jun;3(2). Epub 2013 Apr 1.

Institut de Science des Materiaux de Mulhouse (IS2M); CNRS UMR7361; Universite de Haute-Alsace; Mulhouse, France.

We have recently developed new 3D hydroxyapatite/collagen (50/50 wt%) scaffolds using a biomimetic synthesis approach. The first in vitro tests performed in static culture showed a limited cell colonization and survival inside the scaffolds. The current study evaluated in dynamic culture the scaffold changes and colonization by human immortalized osteoprogenitor STRO-1A cells. Read More

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http://dx.doi.org/10.4161/biom.24922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749797PMC
December 2014

Formulation and optimization of temozolomide nanoparticles by 3 factor 2 level factorial design.

Biomatter 2013 Apr-Jun;3(2). Epub 2013 Apr 1.

Pharmaceutics Research Projects Laboratory; Department of Pharmaceutical Sciences; Sagar, India.

The aim of this study was to investigate the combined influence of 3 independent variables in the preparation of temozolomide bearing Non-PEGylated and PEGylated nanoparticles by emulsification solvent evaporation method. A 3 factor 2 level design was used to derive a polynomial quadratic model and construct contour plots to predict responses. The independent variables selected were concentration of drug (A), concentration of PLGA/PEG-PLGA (B), PVA concentration in aqueous phase (C) and sonication time (D) and evaluated for percentage drug entrapment (PDE) and particle size (PS). Read More

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http://www.tandfonline.com/doi/abs/10.4161/biom.25102
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http://dx.doi.org/10.4161/biom.25102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749802PMC
December 2014
5 Reads

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications.

Biomatter 2013 Apr-Jun;3(2). Epub 2013 Apr 1.

Laboratoire de Biomécanique; Département de Génie; Université de Sherbrooke; Sherbrooke, QC Canada.

Calcium phosphate materials have been used increasingly in the past 40 years as bone graft substitutes in the dental and orthopedic fields. Accordingly, numerous fabrication methods have been proposed and used. However, the controlled production of spherical calcium phosphate particles remains a challenge. Read More

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http://dx.doi.org/10.4161/biom.25103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749799PMC
December 2014
5 Reads

Kinetics and isotherm of fibronectin adsorption to three-dimensional porous chitosan scaffolds explored by ¹²⁵I-radiolabelling.

Biomatter 2013 Apr-Jun;3(2). Epub 2013 Apr 29.

INEB-Instituto de Engenharia Biomédica; Universidade do Porto; Porto, Portugal; Universidade do Porto; Instituto de Ciências Biomédicas Abel Salazar and Faculdade de Engenharia; Porto, Portugal.

In this study, (125)I-radiolabelling was explored to follow the kinetics and isotherm of fibronectin (FN) adsorption to porous polymeric scaffolds, as well as to assess the elution and exchangeability of pre-adsorbed FN following incubation in serum-containing culture medium. Chitosan (CH) porous scaffolds with two different degrees of acetylation (DA 4% and 15%) were incubated in FN solutions with concentrations ranging from 5 to 50 µg/mL. The kinetic and isotherm of FN adsorption to CH were successfully followed using (125)I-FN as a tracer molecule. Read More

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http://dx.doi.org/10.4161/biom.24791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749804PMC
December 2014
4 Reads

Adipose and mammary epithelial tissue engineering.

Biomatter 2013 Jul-Sep;3(3). Epub 2013 Apr 1.

Department of Chemical and Biological Engineering; Princeton University; Princeton, NJ USA; Department of Molecular Biology; Princeton University; Princeton, NJ USA.

Breast reconstruction is a type of surgery for women who have had a mastectomy, and involves using autologous tissue or prosthetic material to construct a natural-looking breast. Adipose tissue is the major contributor to the volume of the breast, whereas epithelial cells comprise the functional unit of the mammary gland. Adipose-derived stem cells (ASCs) can differentiate into both adipocytes and epithelial cells and can be acquired from autologous sources. Read More

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http://dx.doi.org/10.4161/biom.24630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749276PMC
December 2014
2 Reads

Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm.

Biomatter 2013 Jul-Sep;3(3). Epub 2013 Apr 1.

Graduate Interdisciplinary Program of Biomedical Engineering; University of Arizona; Tucson, AZ USA; BIO5 Institute; University of Arizona; Tucson, AZ USA; Department of Biomedical Engineering; University of Arizona; Tucson, AZ USA; Department of Aerospace and Mechanical Engineering; University of Arizona; Tucson, AZ USA.

AAA is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was to determine any changes that occur in the biomechanical response and fiber microstructure in the ApoE(-/-) AngII mouse model of aneurysm during disease progression. Read More

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http://dx.doi.org/10.4161/biom.24648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749278PMC
December 2014
13 Reads

A novel device to stretch multiple tissue samples with variable patterns: application for mRNA regulation in tissue-engineered constructs.

Biomatter 2013 Jul-Sep;3(3). Epub 2013 Apr 1.

Department of Biomedical Engineering; Boston University; Boston, MA USA.

A broad range of cells are subjected to irregular time varying mechanical stimuli within the body, particularly in the respiratory and circulatory systems. Mechanical stretch is an important factor in determining cell function; however, the effects of variable stretch remain unexplored. In order to investigate the effects of variable stretch, we designed, built and tested a uniaxial stretching device that can stretch three-dimensional tissue constructs while varying the strain amplitude from cycle to cycle. Read More

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http://dx.doi.org/10.4161/biom.24650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749279PMC
December 2014
11 Reads