153 results match your criteria Biomaterials research[Journal]


A new prototype melt-electrospinning device for the production of biobased thermoplastic sub-microfibers and nanofibers.

Biomater Res 2019 29;23:10. Epub 2019 Mar 29.

Aachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Brightlands Chemelot Campus, Urmonderbaan 22, 6167 RD Geleen, The Netherlands.

Sub-microfibers and nanofibers have a high surface-to-volume ratio, which makes them suitable for diverse applications including environmental remediation and filtration, energy production and storage, electronic and optical sensors, tissue engineering, and drug delivery. However, the use of such materials is limited by the low throughput of established manufacturing technologies. This short report provides an overview of current production methods for sub-microfibers and nanofibers and then introduces a new melt-electrospinning prototype based on a spinneret with 600 nozzles, thereby providing an important step towards larger-scale production. Read More

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http://dx.doi.org/10.1186/s40824-019-0159-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440082PMC

Review of bone graft and bone substitutes with an emphasis on fracture surgeries.

Biomater Res 2019 14;23. Epub 2019 Mar 14.

1Department of Orthopaedic Surgery, Guro Hospital, Korea University College of Medicine, 80 Guro 2-dong, Guro-gu, Seoul 152-703 South Korea.

Background: Autogenous bone graft is the gold standard bone graft material. However, due to limitations of supply and morbidity associated with autograft harvest, various bone substitutes have been considered. This article aims to review the properties of the bone graft and various bone substitutes currently available in orthopedic surgery. Read More

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http://dx.doi.org/10.1186/s40824-019-0157-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417250PMC

Recent advances in the development of gene delivery systems.

Authors:
Y K Sung S W Kim

Biomater Res 2019 12;23. Epub 2019 Mar 12.

1Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 USA.

Background: Gene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease. The gene therapy is one of promising therapies for a number of diseases such as inherited disorders, viral infection and cancers. Read More

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http://dx.doi.org/10.1186/s40824-019-0156-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261PMC

Correction to: Hypoxic condition enhances chondrogenesis in synovium-derived mesenchymal stem cells.

Biomater Res 2019 4;23. Epub 2019 Mar 4.

Department of Orthopedic Surgery, Seoul National University Hospital, Yongondong, Chongnogu, Seoul, 110-744 Republic of Korea.

[This corrects the article DOI: 10.1186/s40824-018-0134-x.]. Read More

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http://dx.doi.org/10.1186/s40824-019-0158-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399916PMC

Ionic silver functionalized ovine forestomach matrix - a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.

Biomater Res 2019 22;23. Epub 2019 Feb 22.

Aroa Biosurgery, 2 Kingsford Smith Place, PO Box 107111, Auckland Airport, Auckland, 2150 New Zealand.

Background: Antimicrobial technologies, including silver-containing medical devices, are increasingly utilized in clinical regimens to mitigate risks of microbial colonization. Silver-functionalized resorbable biomaterials for use in wound management and tissue regeneration applications have a narrow therapeutic index where antimicrobial effectiveness may be outweighed by adverse cytotoxicity. We examined the effects of ionic silver functionalization of an extracellular matrix (ECM) biomaterial derived from ovine forestomach (OFM-Ag) in terms of material properties, antimicrobial effectiveness and cytotoxicity profile. Read More

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http://dx.doi.org/10.1186/s40824-019-0155-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387525PMC
February 2019
4 Reads

Preservation of allograft bone using a glycerol solution: a compilation of original preclinical research.

Biomater Res 2019 13;23. Epub 2019 Feb 13.

LifeNet Health, 1864 Concert Drive, Virginia Beach, VA 23453 USA.

Background: Bone allografts are used in many orthopedic procedures to provide structural stability as well as an osteoconductive matrix for bone ingrowth and fusion. Traditionally, bone allografts have been preserved by either freezing or freeze-drying. Each of these preservation methods has some disadvantages: Frozen grafts require special shipping and storage conditions, and freeze-drying requires special lyophilization equipment and procedures that may impact biomechanical integrity. Read More

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http://dx.doi.org/10.1186/s40824-019-0154-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373109PMC
February 2019
1 Read

Comparative studies on thin polycaprolactone-tricalcium phosphate composite scaffolds and its interaction with mesenchymal stem cells.

Biomater Res 2019 3;23. Epub 2019 Jan 3.

Department of Chemical and Biomolecular Engineering, Seoul, 01811 Republic of Korea.

Background: Hybrid scaffolds combining biodegradable polymers and ceramic particles for control of cell adhesion and proliferation are interesting materials for tissue engineering applications. Combinations of biodegradable polymers and ceramics are to provide higher beneficial functionalities to tissue engineering scaffolds with addition of different cell specific bio-factors. Many such hybrid combinations have been reported by several researchers around the world by using various methods and solvents as well as bioactive matrix polymers to fabricate such biomaterials. Read More

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http://dx.doi.org/10.1186/s40824-018-0153-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318878PMC
January 2019

3D printable hyaluronic acid-based hydrogel for its potential application as a bioink in tissue engineering.

Biomater Res 2019 6;23. Epub 2019 Feb 6.

3Department of Mechanical System Design Engineering, Seoul National University of Science and Technology, Seoul, 01811 Republic of Korea.

Background: After recognition of 3D printing and injectable hydrogel as a critical issue in tissue/organ engineering and regenerative medicine society, many hydrogels as bioinks have been developed worldwide by using polymeric biomaterials such as gelatin, alginate, hyaluronic acid and others. Even though some gels have shown good performances in 3D bioprinting, still their performances do not meet the requirements enough to be used as a bioink in tissue engineering.

Method: In this study, a hydrogel consisting of three biocompatible biomaterials such as hyaluronic acid (HA), hydroxyethyl acrylate (HEA) and gelatin-methacryloyl, i. Read More

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http://dx.doi.org/10.1186/s40824-018-0152-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364434PMC
February 2019
3 Reads

Bioactive calcium phosphate materials and applications in bone regeneration.

Biomater Res 2019 14;23. Epub 2019 Jan 14.

1Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 152-742 Republic of Korea.

Background: Bone regeneration involves various complex biological processes. Many experiments have been performed using biomaterials in vivo and in vitro to promote and understand bone regeneration. Among the many biomaterials, calcium phosphates which exist in the natural bone have been conducted a number of studies because of its bone regenerative property. Read More

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http://dx.doi.org/10.1186/s40824-018-0149-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332599PMC
January 2019
2 Reads

Cosmeceutical activities of ethanol extract and its ethyl acetate fraction from coffee silverskin.

Biomater Res 2019 14;23. Epub 2019 Jan 14.

Department of Fine Chemistry, Cosmetic R&D center, Cosmetic Industry Coupled Collaboration Center, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul, 01811 Korea.

Background: Coffee silverskin is a thin film that covers the raw coffee bean. In general, coffee silverskin, which detaches during the coffee roasting process, is disposed as firelighters or dispatched to landfills and can cause serious environmental pollution. The aim of this study was to investigate the feasibility of using coffee silverskin as a functional material in cosmetics by evaluating its bioactive ingredients, antioxidative activity, cytoprotective effect, matrix metalloproteinase-1 (MMP-1)-inhibiting effect, and anti-melanogenesis effect. Read More

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http://dx.doi.org/10.1186/s40824-018-0151-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332556PMC
January 2019
5 Reads

Application of Bonelike® as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases.

Biomater Res 2018 29;22:38. Epub 2018 Dec 29.

2Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.

Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s40824-018-0150-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310926PMC
December 2018
11 Reads

Silicone breast implant modification review: overcoming capsular contracture.

Biomater Res 2018 20;22:37. Epub 2018 Dec 20.

3Interdisciplinary Program for Bioengineering, College of Engineering, Seoul National University, Seoul, 08826 Republic of Korea.

Background: Silicone implants are biomaterials that are frequently used in the medical industry due to their physiological inertness and low toxicity. However, capsular contracture remains a concern in long-term transplantation. To date, several studies have been conducted to overcome this problem. Read More

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http://dx.doi.org/10.1186/s40824-018-0147-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302391PMC
December 2018
2 Reads

Recent advances in stem cell therapeutics and tissue engineering strategies.

Biomater Res 2018 19;22:36. Epub 2018 Dec 19.

1Department of Physiology, Pusan National University School of Medicine, Yangsan, 50612 Gyeongsangnam-do Republic of Korea.

Background: Tissue regeneration includes delivering specific types of cells or cell products to injured tissues or organs for restoration of tissue and organ function. Stem cell therapy has drawn considerable attention since transplantation of stem cells can overcome the limitations of autologous transplantation of patient's tissues; however, it is not perfect for treating diseases. To overcome the hurdles associated with stem cell therapy, tissue engineering techniques have been developed. Read More

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http://dx.doi.org/10.1186/s40824-018-0148-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299977PMC
December 2018
1 Read

Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application.

Biomater Res 2018 6;22:35. Epub 2018 Dec 6.

3Department of Mechanical Engineering and Engineering Science, The University of North Carolina at Charlotte, Charlotte, NC USA.

Background: Carbonate apatite (COAp) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, COAp induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s40824-018-0146-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282351PMC
December 2018
13 Reads

Recent updates for biomaterials used in total hip arthroplasty.

Biomater Res 2018 5;22:33. Epub 2018 Dec 5.

Center for Joint Disease, Chonnam National University Hwasun Hospital, 160, Ilsim-Ri, Hwasun-Eup, Hwasun-Gun, Jeonnam 519-809 South Korea.

Background: Total hip arthroplasty (THA) is probably one of the most successful surgical interventions performed in medicine. Through the revolution of hip arthroplasty by principles of low friction arthroplasty was introduced by Sir John Charnley in 1960s. Thereafter, new bearing materials, fixation methods, and new designs has been improved. Read More

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http://dx.doi.org/10.1186/s40824-018-0144-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280401PMC
December 2018

Mitochondria-targeting theranostics.

Authors:
Han Chang Kang

Biomater Res 2018 8;22:34. Epub 2018 Nov 8.

Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662 Republic of Korea.

Background: Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing side effects, as well as the significance of theranostics for delivering therapeutics at the correct locations and doses for diseases throughout diagnosis. Among organelles, mitochondria have received substantial attention due to their significant controlling functions in cells.

Main Body: With the necessity of subcellular organelle-targeting drug delivery and theranostics, examples of mitochondria-targeting moieties and types of mitochondria-targeting theranostics were introduced. Read More

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http://dx.doi.org/10.1186/s40824-018-0145-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225566PMC
November 2018

Nanoengineered, cell-derived extracellular matrix influences ECM-related gene expression of mesenchymal stem cells.

Biomater Res 2018 5;22:32. Epub 2018 Oct 5.

Department of Bio and Brain Engineering, KAIST, Daejeon, 34141 South Korea.

Background: Human mesenchymal stem cells (hMSCs) are, due to their pluripotency, useful sources of cells for stem cell therapy and tissue regeneration. The phenotypes of hMSCs are strongly influenced by their microenvironment, in particular the extracellular matrix (ECM), the composition and structure of which are important in regulating stem cell fate. In reciprocal manner, the properties of ECM are remodeled by the hMSCs, but the mechanism involved in ECM remodeling by hMSCs under topographical stimulus is unclear. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s40824-018-0141-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173882PMC
October 2018
18 Reads

Application of black phosphorus nanodots to live cell imaging.

Biomater Res 2018 4;22:31. Epub 2018 Oct 4.

2Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan, 46241 Republic of Korea.

Background: Black phosphorus (BP) has emerged as a novel class of nanomaterials owing to its unique optical and electronic properties. BP, a two-dimensional (2D) nanomaterial, is a structure where phosphorenes are stacked together in layers by van der Waals interactions. However, although BP nanodots have many advantages, their biosafety and biological effect have not yet been elucidated as compared to the other nanomaterials. Read More

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http://dx.doi.org/10.1186/s40824-018-0142-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172722PMC
October 2018
1 Read

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer.

Biomater Res 2018 26;22:30. Epub 2018 Sep 26.

1Department of Organic Materials Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea.

Background: Mucoadhesive polymers, which may increase the contact time between the polymer and the tissue, have been widely investigated for pharmaceutical formulations. In this study, we developed a new polysaccharide-based mucoadhesive polymer with thermogelling properties.

Methods: Hexanoyl glycol chitosan (HGC), a new thermogelling polymer, was synthesized by the chemical modification of glycol chitosan using hexanoic anhydride. Read More

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http://dx.doi.org/10.1186/s40824-018-0137-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158885PMC
September 2018
1 Read

Layer-by-layer assembled polymeric thin films as prospective drug delivery carriers: design and applications.

Biomater Res 2018 26;22:29. Epub 2018 Sep 26.

Department of Chemical and Biomolecular Engineering, College of Engineering Yonsei University, 50 Yonsei Ro, Seodaemun Gu, Seoul, 038722 Republic of Korea.

Background: The main purpose of drug delivery systems is to deliver the drugs at the appropriate concentration to the precise target site. Recently, the application of a thin film in the field of drug delivery has gained increasing interest because of its ability to safely load drugs and to release the drug in a controlled manner, which improves drug efficacy. Drug loading by the thin film can be done in various ways, depending on type of the drug, the area of exposure, and the purpose of drug delivery. Read More

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http://dx.doi.org/10.1186/s40824-018-0139-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158909PMC
September 2018
1 Read

Hypoxic condition enhances chondrogenesis in synovium-derived mesenchymal stem cells.

Biomater Res 2018 26;22:28. Epub 2018 Sep 26.

Department of Orthopedic Surgery, Seoul National University Hospital, Yongondong Chongnogu, Seoul, 110-744 Republic of Korea.

Background: The chondrogenic differentiation of mesenchymal stem cells (MSCs) is regulated by many factors, including oxygen tensions, growth factors, and cytokines. Evidences have suggested that low oxygen tension seems to be an important regulatory factor in the proliferation and chondrogenic differentiation in various MSCs. Recent studies report that synovium-derived mesenchymal stem cells (SDSCs) are a potential source of stem cells for the repair of articular cartilage defects. Read More

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http://dx.doi.org/10.1186/s40824-018-0134-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158840PMC
September 2018
4 Reads

Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering.

Authors:
Jin Hyun Lee

Biomater Res 2018 26;22:27. Epub 2018 Sep 26.

1Polymer Technology Institute, Sungkyunkwan University, Suwon, Gyeonggi-Do 16419 Republic of Korea.

Background: Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have the injectability with minimal invasiveness and usability for irregularly shaped sites, in addition to typical advantages of conventional hydrogels such as biocompatibility, permeability to oxygen and nutrient, properties similar to the characteristics of the native extracellular matrix, and porous structure allowing therapeutic agents to be loaded.

Main Body: In this article, recent studies of injectable hydrogel systems applicable for therapeutic agent delivery, disease/cancer therapy, and tissue engineering have reviewed in terms of the various factors physically and chemically contributing to sol-gel transition via which gels have been formed. Read More

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http://dx.doi.org/10.1186/s40824-018-0138-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158836PMC
September 2018
1 Read

Micro-CT - a digital 3D microstructural voyage into scaffolds: a systematic review of the reported methods and results.

Biomater Res 2018 26;22:26. Epub 2018 Sep 26.

13B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal.

Background: Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis, and differentiation is related to the design of the scaffolds. Thus, characterization of the scaffolds is highly required. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-018-0136-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158835PMC
September 2018
2 Reads

Clinical development of photodynamic agents and therapeutic applications.

Biomater Res 2018 26;22:25. Epub 2018 Sep 26.

World Class Smart Lab, Department of New Drug Development, Inha University College of Medicine, 366, Seohae-daero, Jung-gu, Incheon, 22332 Republic of Korea.

Background: Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several photodynamic treatments have been extensively studied and the photosensitizers (PS) are key to their biological efficacy, while laser and oxygen allow to appropriate and flexible delivery for treatment of diseases.

Introduction: In presence of oxygen and the specific light triggering, PS is activated from its ground state into an excited singlet state, generates reactive oxygen species (ROS) and induces apoptosis of cancer tissues. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-018-0140-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158913PMC
September 2018
13 Reads

New opportunities for nanoparticles in cancer immunotherapy.

Biomater Res 2018 26;22:24. Epub 2018 Sep 26.

Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi 13488 Republic of Korea.

Background: Recently, cancer immunotherapy has become standard for cancer treatment. Immunotherapy not only treats primary tumors, but also prevents metastasis and recurrence, representing a major advantage over conventional cancer treatments. However, existing cancer immunotherapies have limited clinical benefits because cancer antigens are often not effectively delivered to immune cells. Read More

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http://dx.doi.org/10.1186/s40824-018-0133-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158870PMC
September 2018

Biogenic fabrication and characterization of silver nanoparticles using aqueous-ethanolic extract of lichen () and their antimicrobial activity.

Biomater Res 2018 21;22:23. Epub 2018 Sep 21.

4Department of Ilmul Advia (Unani Pharmacy), Aligarh Muslim University, Aligarh, Uttar Pradesh 202002 India.

Background: Biogenic fabrication of silver nanoparticles from naturally occurring biomaterials provides an alternative, eco-friendly and cost-effective means of obtaining nanoparticles. It is a favourite pursuit of all scientists and has gained popularity because it prevents the environment from pollution. Our main objective to take up this project is to fabricate silver nanoparticles from lichen, and explore their properties. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-018-0135-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151007PMC
September 2018
22 Reads

Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications.

Biomater Res 2018 23;22:22. Epub 2018 Aug 23.

2Department of Biomedical Sciences, BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, 160 Baekseo-ro, Gwangju, 61469 Republic of Korea.

Background: Cancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating cancer cells to evade or defend conventional anti-cancer therapy such as surgery, chemotherapy and radiotherapy. One of the most important challenges in the development of anti-tumor therapy is the successful delivery of therapeutic and imaging agents specifically to solid tumors. Read More

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http://dx.doi.org/10.1186/s40824-018-0132-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108142PMC

A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy.

Biomater Res 2018 14;22:21. Epub 2018 Aug 14.

1School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea.

Background: Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer immunotherapy. However, the majority of tumors are not immunologically rejected since they express self-antigens which are not recognized by CTLs as foreign. To foreignize these tumors for CTL-mediated immunological rejection, it is essential to develop carriers that can effectively deliver foreign antigens to cancer cells. Read More

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http://dx.doi.org/10.1186/s40824-018-0131-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092827PMC
August 2018
10 Reads

Theranostics and contrast agents for magnetic resonance imaging.

Biomater Res 2018 27;22:20. Epub 2018 Jul 27.

Department of Biotechnology, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi do 14662 South Korea.

Background: Magnetic resonance imaging is one of the diagnostic tools that uses magnetic particles as contrast agents. It is noninvasive methodology which provides excellent spatial resolution. Although magnetic resonance imaging offers great temporal and spatial resolution and rapid in vivo images acquisition, it is less sensitive than other methodologies for small tissue lesions, molecular activity or cellular activities. Read More

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http://dx.doi.org/10.1186/s40824-018-0130-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062937PMC
July 2018
14 Reads

Antibody-mediated oral delivery of therapeutic DNA for type 2 diabetes mellitus.

Biomater Res 2018 27;22:19. Epub 2018 Jul 27.

KB-Biomed, Chungju, 27469 Republic of Korea.

Background: Diabetes mellitus (DM) is a chronic progressive metabolic disease that involves uncontrolled elevation of blood glucose levels. Among various therapeutic approaches, GLP-1 prevents type 2 diabetes mellitus (T2DM) patients from experiencing hyperglycemic episodes. However, the short half-life (< 5 min) and rapid clearance of GLP-1 often limits its therapeutic use. Read More

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http://dx.doi.org/10.1186/s40824-018-0129-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062860PMC
July 2018
5 Reads

Classification of gallstones using Fourier-transform infrared spectroscopy and photography.

Biomater Res 2018 18;22:18. Epub 2018 Jul 18.

2Department of Biomedical Engineering, College of Health Science, Eulji University, 553 Sanseongdae-ro, Sujeong-gu, Seongnam, Gyeonggi-do 13135 Republic of Korea.

Background: Gallstones have conventionally been classified by gross inspection into 4 categories: cholesterol gallstones, black pigment (calcium bilirubinate) gallstones, brown gallstones, and mixed gallstones that contain both cholesterol and calcium bilirubinate. Classification using Fourier-transform infrared (FT-IR) spectroscopy supplements gross inspection; however, the issue of ambiguity in gallstone classification has not been fully addressed to date.

Methods: Twenty-six gallstones obtained after surgical gallbladder removal were examined using FT-IR spectroscopy and digital photography, and classified into 6 gallstone groups according to characteristic FT-IR absorption bands. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s40824-018-0128-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052647PMC
July 2018
17 Reads

Synthesis of a gadolinium based-macrocyclic MRI contrast agent for effective cancer diagnosis.

Authors:
Yohan Jeong Kun Na

Biomater Res 2018 13;22:17. Epub 2018 Jun 13.

Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi do 420-743 South Korea.

Background: Gadolinium-based contrast agents are widely used as a contrast agent for magnetic resonance imaging. Since gadolinium ions are toxic, many chelators are developed to bind gadolinium ions to prevent free gadolinium-associated disease. However, many reports indicated that linear chelator-based contrast agents are associated with nephrogenic systemic fibrosis (NSF) in patients with low kidney function. Read More

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http://dx.doi.org/10.1186/s40824-018-0127-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998550PMC
June 2018
3 Reads

Fabrication and optimization of Nanodiamonds-composited poly(ε-caprolactone) fibrous matrices for potential regeneration of hard tissues.

Biomater Res 2018 30;22:16. Epub 2018 May 30.

Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743 Republic of Korea.

Background: Electrospun fibrous matrices are of great importance for tissue engineering and drug delivery device. However, relatively low mechanical strength of the fibrous matrix is one of the major disadvantages. NDs with a positive charge were selected to enhance the mechanical property of a composited fibrous matrix by inducing the intermolecular interaction between NDs and polymer chain. Read More

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http://dx.doi.org/10.1186/s40824-018-0126-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975567PMC

Retraction Note: Fabrication of a microfluidic device for studying the in situ drug-loading/release behavior of graphene oxide-encapsulated hydrogel beads.

Biomater Res 2018 18;22:15. Epub 2018 May 18.

Department of Organic Materials Engineering, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134 Korea.

[This retracts the article DOI: 10.1186/s40824-018-0119-9.]. Read More

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http://dx.doi.org/10.1186/s40824-018-0125-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960204PMC
May 2018
1 Read

Schwann cell durotaxis can be guided by physiologically relevant stiffness gradients.

Biomater Res 2018 9;22:14. Epub 2018 May 9.

1Department of Molecular Pharmacology, Physiology, Brown University, Providence, Rhode Island, 02912 USA.

Background: Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann cells in response to chemical or topographic cues, the current understanding of how the mechanical environment influences migration remains largely understudied and incomplete. Therefore, the focus of this study was to evaluate Schwann cell migration and morphodynamics in the presence of stiffness gradients, which revealed that Schwann cells can follow extracellular gradients of increasing stiffness, in a form of directed migration termed durotaxis. Read More

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http://dx.doi.org/10.1186/s40824-018-0124-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948700PMC

Induction of chondrogenesis of human placenta-derived mesenchymal stem cells via heparin-grafted human fibroblast derived matrix.

Biomater Res 2018 9;22:12. Epub 2018 May 9.

1Center for Biomaterials, Korea Institute of Science and Technology, Seoul, 02792 South Korea.

Background: Formation of mature and functional articular cartilage is still challenging in cartilage tissue engineering. This study investigates the potential of using heparin-grafted decellularized extracellular matrix (ECM) as a novel growth factor delivery platform towards human placenta-derived mesenchymal stem cells (hPMSCs) chondrogenic differentiation. Human fibroblast-derived extracellular matrix (hFDM) is naturally obtained from in vitro-cultured human lung fibroblasts via a mild decellularization process. Read More

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http://dx.doi.org/10.1186/s40824-018-0121-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941790PMC
May 2018
5 Reads

Application of click chemistry in nanoparticle modification and its targeted delivery.

Biomater Res 2018 13;22:13. Epub 2018 Apr 13.

1Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591 Republic of Korea.

Background: Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative example where click chemistry showed its promising potential. Challenging trials with nanoparticles has been reported based on click chemistry including copper-catalyzed cycloaddition, strain-promoted azide-alkyne cycloaddition, and inverse-demand Diels-Alder reaction. Read More

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http://dx.doi.org/10.1186/s40824-018-0123-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899385PMC
April 2018
2 Reads

Recent trends in bioinks for 3D printing.

Biomater Res 2018 6;22:11. Epub 2018 Apr 6.

1Department of Chemical & Biomolecular Engineering, Seoul National University of Science and Technology (Seoul Tech), Gongneung-ro 232, Nowon-Gu, Seoul, 01811 Republic of Korea.

Background: The worldwide demand for the organ replacement or tissue regeneration is increasing steadily. The advancements in tissue engineering and regenerative medicine have made it possible to regenerate such damaged organs or tissues into functional organ or tissue with the help of 3D bioprinting. The main component of the 3D bioprinting is the bioink, which is crucial for the development of functional organs or tissue structures. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-018-0122-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889544PMC
April 2018
28 Reads

Two-dimensional material-based bionano platforms to control mesenchymal stem cell differentiation.

Biomater Res 2018 2;22:10. Epub 2018 Apr 2.

1School of Integrative Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.

Background: In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repair damaged parts of organs and tissues, the use of stem cells still entails several limitations, such as low differentiation efficiency and difficulties in guiding differentiation. To address these limitations, nanotechnology approaches have been recently implemented in stem cell research. Read More

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http://dx.doi.org/10.1186/s40824-018-0120-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879765PMC

Regulation of lubricin for functional cartilage tissue regeneration: a review.

Biomater Res 2018 16;22. Epub 2018 Mar 16.

1School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 Republic of Korea.

Background: Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and multifaceted matter is a major concern in the field of cartilage tissue engineering. Read More

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http://dx.doi.org/10.1186/s40824-018-0118-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857089PMC
March 2018
12 Reads

Analysis of trends and prospects regarding stents for human blood vessels.

Biomater Res 2018 13;22. Epub 2018 Mar 13.

3Korea Institute of Science and Technology Information, 66 Heogi-ro, 570 Dongdeamoon-gu, Seoul, 02456 Korea.

Background: The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world.A stent is a medical device in the form of a cylindrical metal net used to normalize flow when blood or other bodily fluids such as biliary fluids are obstructed in blood vessels, gastrointestinal tracts, etc. by inserting the stent into a narrowed or clogged area. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-018-0114-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851094PMC
March 2018
4 Reads

Fabrication of a microfluidic device for studying the in situ drug-loading/release behavior of graphene oxide-encapsulated hydrogel beads.

Biomater Res 2018 13;22. Epub 2018 Mar 13.

Department of Organic Materials Engineering, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134 Korea.

Background: Controlled drug delivery system is highly important for not only prolonged the efficacy of drug but also cellular development for tissue engineering. A number of biopolymer composites and nanostructured carriers behave been used for the controlled drug delivery of therapeutics. Recently, in vitro microfluidic devices that mimic the human body have been developed for drug-delivery applications. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-018-0119-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851251PMC
March 2018
7 Reads

The effect of serum types on Chondrogenic differentiation of adipose-derived stem cells.

Biomater Res 2018 9;22. Epub 2018 Mar 9.

Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, 22012 South Korea.

Background: Fetal bovine serum (FBS) is the most essential supplement in culture media for cellular proliferation, metabolism, and differentiation. However, due to a limited supply and subsequently rising prices, a series of studies have investigated a biological feasibility of replaceable serums to substitute FBS. Along with the increasing interests to manufacture stem cell-based cellular products, optimizing the composition of culture media including serums and exogenous growth factors (GFs) is of importance. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-018-0116-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845156PMC
March 2018
4 Reads

Ferritin nanoparticles for improved self-renewal and differentiation of human neural stem cells.

Biomater Res 2018 27;22. Epub 2018 Feb 27.

Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea.

Background: Biomaterials that promote the self-renewal ability and differentiation capacity of neural stem cells (NSCs) are desirable for improving stem cell therapy to treat neurodegenerative diseases. Incorporation of micro- and nanoparticles into stem cell culture has gained great attention for the control of stem cell behaviors, including proliferation and differentiation.

Method: In this study, ferritin, an iron-containing natural protein nanoparticle, was applied as a biomaterial to improve the self-renewal and differentiation of NSCs and neural progenitor cells (NPCs). Read More

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http://dx.doi.org/10.1186/s40824-018-0117-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828329PMC
February 2018
3 Reads

Differentiated osteoblasts derived decellularized extracellular matrix to promote osteogenic differentiation.

Biomater Res 2018 23;22. Epub 2018 Feb 23.

1Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714 Republic of Korea.

Background: The extracellular matrix (ECM) can directly or indirectly influence on regulation of cell functions such as cell adhesion, migration, proliferation and differentiation. The cell derived ECM (CD-ECM) is a useful in vitro model for studying the comprehensive functions of CD-ECM because it maintains a native-like structure and composition. In this study, the CD-ECM is obtained and a test is carried out to determine the effectiveness of several combinations of decellularized methods. Read More

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http://dx.doi.org/10.1186/s40824-018-0115-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824473PMC
February 2018
42 Reads

Sulfobetaine methacrylate hydrogel-coated anti-fouling surfaces for implantable biomedical devices.

Biomater Res 2018 12;22. Epub 2018 Feb 12.

Department of Molecular Science and Technology, Ajou University, San 5, Woncheon, Yeongtong, Suwon, 16499 Republic of Korea.

Background: Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numerous studies on surface modification using zwitterionic molecules have been investigated, such as electrochemically mediated and photoinitiated radical polymerization. However, these methods have some limitations, including multi-step process, difficulties in producing thick and dense layers as well as the requirement of extra facilities. Read More

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http://dx.doi.org/10.1186/s40824-017-0113-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808389PMC
February 2018
9 Reads

The market trend analysis and prospects of cancer molecular diagnostics kits.

Biomater Res 2018 15;22. Epub 2018 Jan 15.

1Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763 South Korea.

Background: The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnostic technique. Also, depending on the disease being diagnosed, the market can also be divided into cancer, infectious diseases, HIV/STDs (herpes, syphilis), and women's health issues such as breast cancer, cervical cancer, ovarian cancer, HPV(human papillomavirus), and vaginitis.Chromosome analysis (including Fluorescent In-situ Hybridization) is one type of blood cancer diagnostic method, which involves the direct detection of individual cells with chromosomal translocation, but there have been problems of sensitivity when using this method. Read More

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http://dx.doi.org/10.1186/s40824-017-0111-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767967PMC
January 2018
5 Reads

Enhanced osteogenic commitment of murine mesenchymal stem cells on graphene oxide substrate.

Biomater Res 2018 2;22. Epub 2018 Jan 2.

School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742 Republic of Korea.

Background: Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxide (GO) is considered as promising biomaterial due to its nontoxicity, high dispersity, and hydrophilic interaction, and these characteristics are key to stimulating the interactions between substrates and cells.

Method: In this study, GO substrates were fabricated via chemically immobilizing GO at 1. Read More

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http://dx.doi.org/10.1186/s40824-017-0112-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748957PMC
January 2018
7 Reads

Comparison of in vivo antibacterial and antithrombotic activities of two types of pulmonary artery catheters in pig.

Biomater Res 2017 15;21:23. Epub 2017 Nov 15.

Department of Thoracic and Cardiovascular Surgery, Korea University Medical Center, #73, Inchon-Ro, Sungbuk-Gu, Seoul, 136-705 South Korea.

Background: During pulmonary artery catheter (PAC) implantation, inaccurate measurements of hemodynamic parameters due to infection or thrombosis of PAC can result in severe complications.

Method: In order to develop a new PAC material, we evaluated the antibacterial and antithrombotic activities of the two types of PAC (Swan Ganz catheter and prototype catheter) in 14 pigs.

Results: In the 3-day group, bacterial infection rate was not different between the two types of PAC. Read More

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http://dx.doi.org/10.1186/s40824-017-0109-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686838PMC
November 2017
8 Reads

Proangiogenic alginate-g-pyrrole hydrogel with decoupled control of mechanical rigidity and electrically conductivity.

Biomater Res 2017 7;21:24. Epub 2017 Nov 7.

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.

Background: An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing elastic modulus of the hydrogels because of decreased transport of ions through a polymeric cross-linked mesh.

Method: This study hypothesized that the inverse dependency between electrical conductivity and elastic modulus would be made through the cross-linking of conductive monomer-units conjugated to a hydrophilic polymeric backbone. Read More

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http://dx.doi.org/10.1186/s40824-017-0110-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678582PMC
November 2017
3 Reads