184 results match your criteria Biomaterials research[Journal]


Recent advances in polymeric drug delivery systems.

Biomater Res 2020 6;24:12. Epub 2020 Jun 6.

Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, BPRB, Room 205, Salt Lake City, UT 84112 USA.

Background: Polymeric drug delivery systems have been achieved great development in the last two decades. Polymeric drug delivery has defined as a formulation or a device that enables the introduction of a therapeutic substance into the body. Biodegradable and bio-reducible polymers make the magic possible choice for lot of new drug delivery systems. Read More

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http://dx.doi.org/10.1186/s40824-020-00190-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285724PMC

Current status of plant metabolite-based fabrication of copper/copper oxide nanoparticles and their applications: a review.

Biomater Res 2020 3;24:11. Epub 2020 Jun 3.

Wolaita Sodo University, P.O. Box: 138, Wolaita, Ethiopia.

Since green mode of nanoparticles (NPs) synthesis is simple, advantageous and environment friendly relative to chemical and physical procedures, various plant species have been used to fabricate copper and copper oxide nanoparticles (Cu/CuO-NPs) owing to the presence of phytochemicals which often act as capping as well as stabilizing agent. These Cu/CuO-NPs are highly stable and used in the degradation of organic dyes like methylene blue and reduction of organic compounds such as phenols. They are also used as antibacterial, antioxidant and antifungal agent due to their cytotoxicity. Read More

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http://dx.doi.org/10.1186/s40824-020-00188-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268245PMC

Electrically stimulable indium tin oxide plate for long-term in vitro cardiomyocyte culture.

Biomater Res 2020 27;24:10. Epub 2020 May 27.

Research Group for Biomimetic Advanced Technology, Korea Institute of Toxicology, Daejeon, South Korea.

Background: We investigated whether electrical stimulation via indium tin oxide (ITO) could enhance the in vitro culture of neonatal rat ventricular myocytes (NRVMs), which are important in vitro models for studying the mechanisms underlying many aspects of cardiology.

Methods: Cardiomyocytes were obtained from 1-day-old neonatal rat heart ventricles. To evaluate function of NRVMs cultured on ITO with electrical stimulation, the cell viability, change of cell morphology, immunochemistry using cardiac-specific antibodies, and gene expression were tested. Read More

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http://dx.doi.org/10.1186/s40824-020-00189-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251917PMC

Synthesizing efficacious genistein in conjugation with superparamagnetic FeO decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma.

Biomater Res 2020 20;24. Epub 2020 Mar 20.

2Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Background: Genistein (CHO) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle. Read More

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http://dx.doi.org/10.1186/s40824-020-00187-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082912PMC

Fabrication and characterization of tretinoin-loaded nanofiber for topical skin delivery.

Biomater Res 2020 2;24. Epub 2020 Mar 2.

4Department of Clinical Microbiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Background: Tretinoin or all-trans retinoic acid is used in the treatment of acne vulgaris and photo-aging. This work aims to develop tretinoin-loaded nanofibers as a potential anti-acne patch and to investigate its physicochemical characteristics.

Method: Nanofibers were produced via electrospinning method and surface topography was evaluated by Field Emission Scanning Electron Microscopy (FESEM). Read More

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http://dx.doi.org/10.1186/s40824-020-00186-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053082PMC

Biomaterials in orthopaedics: the past and future with immune modulation.

Authors:
Gun-Il Im

Biomater Res 2020 4;24. Epub 2020 Feb 4.

Research Institute for Integrative Regenerative Biomedical Engineering, Dongguk University Ilsan Hospital, 814 Siksa-Dong, Goyang, 410-773 Republic of Korea.

Orthopaedics owes its current status of advanced care to the development of biomaterial science more than any other clinical medical specialty. The purpose of this brief review is to introduce the history and present status of biomaterials in orthopaedic field and cast a perspective on the future use of biomaterials to treat musculoskeletal disorders with particular emphasis on immune modulation. While the biomaterials in orthopaedics started from inert materials to replace the function and structure of hard tissue such as bone and cartilage, regenerative medicine will play a greater role in preventing the traumatic loss of tissues, as well as in the earlier stages of diseases. Read More

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http://dx.doi.org/10.1186/s40824-020-0185-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001269PMC
February 2020

Electrochemical biosensors: perspective on functional nanomaterials for on-site analysis.

Biomater Res 2020 4;24. Epub 2020 Feb 4.

3Department of Biomedical Engineering, College of Health Science, Eulji University, Seongnam, 13135 Republic of Korea.

Background: The electrochemical biosensor is one of the typical sensing devices based on transducing the biochemical events to electrical signals. In this type of sensor, an electrode is a key component that is employed as a solid support for immobilization of biomolecules and electron movement. Thanks to numerous nanomaterials that possess the large surface area, synergic effects are enabled by improving loading capacity and the mass transport of reactants for achieving high performance in terms of analytical sensitivity. Read More

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http://dx.doi.org/10.1186/s40824-019-0181-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001310PMC
February 2020

The efficacy of rhBMP-2 loaded hydrogel composite on bone formation around dental implants in mandible bone defects of minipigs.

Biomater Res 2020 3;24. Epub 2020 Feb 3.

1Department of Orthopedic Surgery, College of Medicine, SMG-SNU Boramae Medical Center, Seoul National University, Boramae-ro 5-gil 20, Dongjak-gu, Seoul, 07061 Korea.

Background: In dental or orthopedic surgery, bone substitutes are inserted with implants to promote osteogenesis and enhance osseointegration. The purpose of this research was to evaluate the efficacy of rhBMP-2 (recombinant human bone morphogenetic protein-2) loaded hydrogel composite for bone formation around dental implant in minipig mandible bone defect models.

Methods: We made bone defects with a diameter of 4 mm in minipig mandibles and inserted implants of the same size, to mimic the cases of inserting the screws in the bone defect or poor-quality bone. Read More

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http://dx.doi.org/10.1186/s40824-020-0183-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998194PMC
February 2020

Mechanical and physio-biological properties of peptide-coated stent for re-endothelialization.

Biomater Res 2020 23;24. Epub 2020 Jan 23.

CGBio Co. Ltd., Jangseong, 57248 Republic of Korea.

Background: The aim of this study was to characterize the mechanical and physio-biological properties of peptide-coated stent (PCS) compared to commercialized drug-eluting stents (DESs).

Methods: WKYMVm (Trp-Lys-Tyr-Met-Val-D-Met), a stimulating peptide for homing endothelial colony-forming cell was specially synthesized and coated to bare metal stent (BMS) by dopamine-derived coordinated bond. Biological effects of PCS were investigated by endothelial cell proliferation assay and pre-clinical animal study. Read More

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http://dx.doi.org/10.1186/s40824-020-0182-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979279PMC
January 2020

Emerging role of nanosuspensions in drug delivery systems.

Biomater Res 2020 15;24. Epub 2020 Jan 15.

3Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat India.

Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle many formulation and drug delivery issues typically associated with poorly water and lipid soluble drugs. Conventional size reduction equipment such as media mill and high-pressure homogenizers and formulation approaches such as precipitation, emulsion-solvent evaporation, solvent diffusion and microemulsion techniques can be successfully implemented to prepare and scale-up nanosuspensions. Read More

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http://dx.doi.org/10.1186/s40824-020-0184-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964012PMC
January 2020

Role of offset and gradient architectures of 3-D melt electrowritten scaffold on differentiation and mineralization of osteoblasts.

Biomater Res 2020 3;24. Epub 2020 Jan 3.

1School of Dentistry and Oral Health, Griffith University, Gold Coast Campus, Southport, Queensland 4215 Australia.

Background: Cell-scaffold based therapies have the potential to offer an efficient osseous regenerative treatment and PCL has been commonly used as a scaffold, however its effectiveness is limited by poor cellular retention properties. This may be improved through a porous scaffold structure with efficient pore arrangement to increase cell entrapment. To facilitate this, melt electrowriting (MEW) has been developed as a technique able to fabricate cell-supporting scaffolds with precise micro pore sizes via predictable fibre deposition. Read More

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http://dx.doi.org/10.1186/s40824-019-0180-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942301PMC
January 2020

Oleic acid conjugated polymeric photosensitizer for metastatic cancer targeting in photodynamic therapy.

Authors:
Sanghee Lee Kun Na

Biomater Res 2020 3;24. Epub 2020 Jan 3.

Department of Biotechnology, Department of Biomedical-Chemical Engineering, Center for Photomedicine, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662 South Korea.

Background: Cancer has been conquered by recent advances in chemotherapy, targeted therapy, and their combinations. However, 90 % of cancer patients die due to cancer recurrence or metastasis. Cancer cell change their metabolic properties to metastasize, changing from conventional glycometabolism to fat metabolism. Read More

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http://dx.doi.org/10.1186/s40824-019-0177-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942285PMC
January 2020

Age- and sex-dependence of five major elements in the development of human scalp hair.

Biomater Res 2019 21;23:29. Epub 2019 Dec 21.

3Department of Biomedical Engineering, College of Bio-convergence, Eulji University, Seongnam, Gyeonggi-do 13135 South Korea.

Background: Human scalp hair is composed of bio-synthesized protein that stores and excretes excess elements from the body. Thus, the concentration of major and trace elements in the hair may provide insight into both the physiology and health status of humans. Monitoring of health status by hair analysis is limited by the uncertainty surrounding natural changes in composition based on age and sex parameters. Read More

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http://dx.doi.org/10.1186/s40824-019-0179-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925836PMC
December 2019

Osteoblast behaviours on nanorod hydroxyapatite-grafted glass surfaces.

Biomater Res 2019 21;23:28. Epub 2019 Dec 21.

1Department of Polymer Science and Engineering, Kyungpook National University, Daegu, 702-701 South Korea.

Background: The goal of this study is to obtain basic information to improve the bone adhesion of silica components, which are used as the main ingredient in glass ionomer cement (GIC). To achieve this, nanorod hydroxyapatite (nHA) was grafted to the surface of silica cover glass. Surface analysis confirmed nHA was joined to the glass surface and biocompatibility with osteoblasts was investigated. Read More

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http://dx.doi.org/10.1186/s40824-019-0178-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925421PMC
December 2019

Optimization of silver nanoparticle synthesis by chemical reduction and evaluation of its antimicrobial and toxic activity.

Biomater Res 2019 19;23:27. Epub 2019 Dec 19.

1Centro de Bioingeniería, Grupo de investigaciones en Bioingeniería, Universidad Pontificia Bolivariana, circular 1 No. 73-76, Medellín, 050031 Colombia.

Background: Chemical reduction has become an accessible and useful alternative to obtain silver nanoparticles (AgNPs). However, its toxicity capacity depends on multiple variables that generate differences in the ability to inhibit the growth of microorganisms. Thus, optimazing parameters for the synthesis of AgNPs can increase its antimicrobial capacity by improving its physical-chemical properties. Read More

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http://dx.doi.org/10.1186/s40824-019-0173-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921438PMC
December 2019

Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts.

Biomater Res 2019 18;23:26. Epub 2019 Dec 18.

9Orthopedics and Trauma Surgery Center, Technische Universität Dresden, Dresden, Germany.

Background: Delayed bone regeneration of fractures in osteoporosis patients or of critical-size bone defects after tumor resection are a major medical and socio-economic challenge. Therefore, the development of more effective and osteoinductive biomaterials is crucial.

Methods: We examined the osteogenic potential of macroporous scaffolds with varying pore sizes after biofunctionalization with a collagen/high-sulfated hyaluronan (sHA3) coating in vitro The three-dimensional scaffolds were made up from a biodegradable three-armed lactic acid-based macromer (TriLA) by cross-polymerization. Read More

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http://dx.doi.org/10.1186/s40824-019-0172-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921484PMC
December 2019

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering.

Biomater Res 2019 5;23:25. Epub 2019 Dec 5.

5Institute of Natural Sciences, Yonsei University, 134 Shinchon-dong, Seodaemoon-gu, Seoul, 03722 Republic of Korea.

Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Read More

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http://dx.doi.org/10.1186/s40824-019-0176-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896676PMC
December 2019

Therapeutic efficacy of nanoparticles and routes of administration.

Biomater Res 2019 21;23:20. Epub 2019 Nov 21.

5Research and Policy Department, World Innovation Summit for Health (WISH), Qatar Foundation, P.O. Box 5825, Doha, Qatar.

In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term "nanomaterials" describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, "engineered" nanomaterials have received significant attention due to their versatility. Read More

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http://dx.doi.org/10.1186/s40824-019-0166-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869321PMC
November 2019

Gemcitabine-incorporated polyurethane films for controlled release of an anticancer drug.

Biomater Res 2019 20;23:19. Epub 2019 Nov 20.

3Department of Biomedical Engineering, College of Health Science, Eulji University, 553 Sanseongdae-ro, Sujeong-gu, Seongnam-si, Gyeonggi-do 13135 Republic of Korea.

Background: Local delivery of anti-cancer drugs through a stent is a very promising and anticipated treatment modality for patients who have obstructions in their gastrointestinal tract with malignant tumors. Anticancer drug release via stents, however, needs to be optimized with respect to drug delivery behavior for the stents to be effective for prolonged containment of tumor proliferation and stent re-obstruction. Local stent-based drug delivery has been tested using an effective anti-cancer drug, gemcitabine, but the release from the stent-coated polyurethane films is often too fast and the drug is depleted from the coated film virtually in a day. Read More

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http://dx.doi.org/10.1186/s40824-019-0169-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865006PMC
November 2019

Recent advances in melanin-like nanomaterials in biomedical applications: a mini review.

Biomater Res 2019 3;23:24. Epub 2019 Dec 3.

Department of Emerging Materials Science, DGIST, Daegu, 42988 South Korea.

Background: Melanins are a group of biopigments in microorganisms that generate a wide range of colorants. Due to their multifunctionality, including ultraviolet protection, radical scavenging, and photothermal conversion, in addition to their intrinsic biocompatibility, natural melanins and synthetic melanin-like nanomaterials have been suggested as novel nano-bio platforms in biomedical applications.

Main Body: Recent approaches in the synthesis of melanin-like nanomaterials and their biomedical applications have briefly been reviewed. Read More

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http://dx.doi.org/10.1186/s40824-019-0175-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889561PMC
December 2019

Recent advances in the development of nature-derived photocrosslinkable biomaterials for 3D printing in tissue engineering.

Biomater Res 2019 19;23:18. Epub 2019 Nov 19.

Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673 South Korea.

Background: In recent years, three-dimensional (3D) printing has begun to be widely used in tissue engineering. Natural biomaterials have been employed to overcome the limitations of synthetic polymers. However, their low mechanical strength and poor printability are major disadvantages. Read More

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http://dx.doi.org/10.1186/s40824-019-0168-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862824PMC
November 2019

Comparison of cytotoxicity of black phosphorus nanosheets in different types of fibroblasts.

Biomater Res 2019 29;23:23. Epub 2019 Nov 29.

1Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan, 46241 South Korea.

Background: Two-dimensional black phosphorus nanosheets (BPNSs) have recently emerged as a successive novel nanomaterial owing to their uniqueness in optical and electrical properties. Although BPNSs have found a wide range of biomedical applications, their biosafety is still a major concern to be addressed.

Methods: In this study, we have prepared layered BPNSs using liquid exfoliation procedure, and evaluated their physicochemical properties using Fourier Transform-infrared (FTIR) spectroscopy, Raman spectroscopy, atomic force microscopy, and Zetasizer analyses. Read More

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http://dx.doi.org/10.1186/s40824-019-0174-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884905PMC
November 2019

3D printed mesh reinforcements enhance the mechanical properties of electrospun scaffolds.

Biomater Res 2019 29;23:22. Epub 2019 Nov 29.

2Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, USA.

Background: There is substantial interest in electrospun scaffolds as substrates for tissue regeneration and repair due to their fibrous, extracellular matrix-like composition with interconnected porosity, cost-effective production, and scalability. However, a common limitation of these scaffolds is their inherently low mechanical strength and stiffness, restricting their use in some clinical applications. In this study we developed a novel technique for 3D printing a mesh reinforcement on electrospun scaffolds to improve their mechanical properties. Read More

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http://dx.doi.org/10.1186/s40824-019-0171-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884787PMC
November 2019

Effects of motion direction and power of Er,Cr:YSGG laser on pull-out bond strength of fiber post to root dentin in endodontically-treated single-canal premolar teeth.

Biomater Res 2019 15;23:17. Epub 2019 Nov 15.

4Department of Periodontology, Laser Research Center in Medical Sciences, Dental Faculty, AJA University of Medical Sciences, Tehran, Iran.

Background: Inadequate retention and gradual debonding of intracanal post from root dentin is a major cause of failure of endodontically treated teeth restored with fiber post.

Main Body: This study aimed to assess the effect of surface treatment of quartz fiber posts with different powers and motion directions of Er,Cr:YSGG laser on their pull-out bond strength to root dentin in endodontically treated premolar teeth. In this study, 105 fiber posts were divided into 7 groups according to their surface treatment with different powers of Er,Cr:YSGG laser at 2780 nm wavelength, 20 Hz frequency and 150 μs pulse duration in circumferential (C) or longitudinal (L) motion directions: Control group (no treatment), 0. Read More

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http://dx.doi.org/10.1186/s40824-019-0165-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858750PMC
November 2019

Effect of photoinitiator on chain degradation of hyaluronic acid.

Biomater Res 2019 21;23:21. Epub 2019 Nov 21.

1Department of Advanced Organic Materials and Textile System Engineering, College of Engineering, Chungnam National University, Daejeon, 34134 South Korea.

Objectives: Photocrosslinking systems of polymers have been widely studied using UV or visible light irradiation. However, the photodegradation behavior derived from light irradiation was rarely reported, comparing with the photocrosslinking. In this study, the tyramine-modified hyaluronic acid (HA/Tyr) hydrogel was prepared using riboflavin (RF) as a photoinitiator, and the degradation behavior of HA by the reactive oxygen species (ROS) generated in photochemical process was investigated. Read More

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http://dx.doi.org/10.1186/s40824-019-0170-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873473PMC
November 2019

Transdermal delivery of Minoxidil using HA-PLGA nanoparticles for the treatment in alopecia.

Biomater Res 2019 31;23:16. Epub 2019 Oct 31.

1Department of Organic Materials Science and Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan, 46241 Republic of Korea.

Background: Alopecia has become a very common disease that many people around the world are suffered. Minoxidil (MXD) is the most well-known commercialized drug in its treatment. However, in the case of MXD administration, there are some problems with low efficiency of transdermal delivery and additional side effects. Read More

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http://dx.doi.org/10.1186/s40824-019-0164-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824046PMC
October 2019
2 Reads

Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells.

Biomater Res 2019 17;23:15. Epub 2019 Oct 17.

4Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis, 723 W. Michigan Ave SL260, Indianapolis, IN 46202 USA.

Background: Collagen-based scaffolds reinforced with hydroxyapatite (HA) are an attractive choice for bone tissue engineering because their composition mimics that of bone. We previously reported the development of compression-molded collagen-HA scaffolds that exhibited high porosity, interconnected pores, and mechanical properties that were well-suited for surgical handling and fixation. The objective of this study was to investigate these novel collagen-HA scaffolds in combination with human adipose-derived stem cells (hASCs) as a template for bone formation in a subcutaneous athymic mouse model. Read More

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http://dx.doi.org/10.1186/s40824-019-0167-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796373PMC
October 2019

Retro MTA and tricalcium phosphate/retro MTA for guided tissue regeneration of periodontal dehiscence defects in a dog model: a pilot study.

Biomater Res 2019 28;23:14. Epub 2019 Aug 28.

1Department of Periodontics and Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Objectives: Retro MTA is a fast setting Calcium silicate cement used in endodontic regeneration procedures in recent years. Beta-tricalcium phosphate (β-TCP) is another common biomaterial used for bone augmentation procedures. The present pilot study was undertaken to evaluate and compare the efficacy of Retro MTA and a mixture of Retro MTA / β-TCP for periodontal tissue regeneration. Read More

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http://dx.doi.org/10.1186/s40824-019-0163-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712858PMC

Epsilon-FeO is a novel intermediate for magnetite biosynthesis in magnetotactic bacteria.

Biomater Res 2019 2;23:13. Epub 2019 Aug 2.

1State Key Laboratory of Agrobiotechnology and Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, 100193 People's Republic of China.

Background: Natural biological magnetite nanoparticles are widely distributed from microorganisms to humans. It is found to be very important in organisms, especially in navigation. Moreover, purified magnetite nanoparticles also have potential applications in bioengineering and biomedicine. Read More

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http://dx.doi.org/10.1186/s40824-019-0162-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679552PMC

Effects of micro-porosity and local BMP-2 administration on bioresorption of β-TCP and new bone formation.

Biomater Res 2019 26;23:12. Epub 2019 Jul 26.

1Department of Orthopaedic Surgery, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-0003 Japan.

Background: It has been reported that the microporous structure of calcium phosphate (CaP) ceramics is important to osteoconduction. Bone morphogenetic protein-2 (BMP-2) has been shown to be a promising alternative to bone grafting and a therapeutic agent promoting bone regeneration when delivered locally. The aim of this study was to evaluate the effects of micro-porosity within beta-tricalcium phosphate (β-TCP) cylinders and local BMP-2 administration on β-TCP resorption and new bone formation. Read More

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http://dx.doi.org/10.1186/s40824-019-0161-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660686PMC

Tissue engineering a tendon-bone junction with biodegradable braided scaffolds.

Biomater Res 2019 16;23:11. Epub 2019 May 16.

5Department of Pediatrics, University of Nebraska Medical Center, Children's Hospital & Medical Center, Omaha, NE 68198-5945 USA.

Background: Tendons play an important role in transferring stress between muscles and bones and in maintaining the stability of joints. Tendon tears are difficult to heal and are associated with high recurrence rates. So, the objective of this study was to develop a biodegradable scaffold for tendon-bone junction regeneration. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40824-019-0160-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521458PMC
May 2019
8 Reads

A new prototype melt-electrospinning device for the production of biobased thermoplastic sub-microfibers and nanofibers.

Biomater Res 2019 29;23:10. Epub 2019 Mar 29.

Aachen-Maastricht Institute for Biobased Materials (AMIBM), Maastricht University, Brightlands Chemelot Campus, Urmonderbaan 22, 6167 RD Geleen, The Netherlands.

Sub-microfibers and nanofibers have a high surface-to-volume ratio, which makes them suitable for diverse applications including environmental remediation and filtration, energy production and storage, electronic and optical sensors, tissue engineering, and drug delivery. However, the use of such materials is limited by the low throughput of established manufacturing technologies. This short report provides an overview of current production methods for sub-microfibers and nanofibers and then introduces a new melt-electrospinning prototype based on a spinneret with 600 nozzles, thereby providing an important step towards larger-scale production. Read More

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http://dx.doi.org/10.1186/s40824-019-0159-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440082PMC
March 2019
7 Reads

Review of bone graft and bone substitutes with an emphasis on fracture surgeries.

Biomater Res 2019 14;23. Epub 2019 Mar 14.

1Department of Orthopaedic Surgery, Guro Hospital, Korea University College of Medicine, 80 Guro 2-dong, Guro-gu, Seoul 152-703 South Korea.

Background: Autogenous bone graft is the gold standard bone graft material. However, due to limitations of supply and morbidity associated with autograft harvest, various bone substitutes have been considered. This article aims to review the properties of the bone graft and various bone substitutes currently available in orthopedic surgery. Read More

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http://dx.doi.org/10.1186/s40824-019-0157-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417250PMC
March 2019
2 Reads

Recent advances in the development of gene delivery systems.

Authors:
Y K Sung S W Kim

Biomater Res 2019 12;23. Epub 2019 Mar 12.

1Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112 USA.

Background: Gene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease. The gene therapy is one of promising therapies for a number of diseases such as inherited disorders, viral infection and cancers. Read More

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http://dx.doi.org/10.1186/s40824-019-0156-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261PMC
March 2019
2 Reads

Correction to: Hypoxic condition enhances chondrogenesis in synovium-derived mesenchymal stem cells.

Biomater Res 2019 4;23. Epub 2019 Mar 4.

Department of Orthopedic Surgery, Seoul National University Hospital, Yongondong, Chongnogu, Seoul, 110-744 Republic of Korea.

[This corrects the article DOI: 10.1186/s40824-018-0134-x.]. Read More

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http://dx.doi.org/10.1186/s40824-019-0158-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399916PMC
March 2019
2 Reads

Ionic silver functionalized ovine forestomach matrix - a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.

Biomater Res 2019 22;23. Epub 2019 Feb 22.

Aroa Biosurgery, 2 Kingsford Smith Place, PO Box 107111, Auckland Airport, Auckland, 2150 New Zealand.

Background: Antimicrobial technologies, including silver-containing medical devices, are increasingly utilized in clinical regimens to mitigate risks of microbial colonization. Silver-functionalized resorbable biomaterials for use in wound management and tissue regeneration applications have a narrow therapeutic index where antimicrobial effectiveness may be outweighed by adverse cytotoxicity. We examined the effects of ionic silver functionalization of an extracellular matrix (ECM) biomaterial derived from ovine forestomach (OFM-Ag) in terms of material properties, antimicrobial effectiveness and cytotoxicity profile. Read More

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http://dx.doi.org/10.1186/s40824-019-0155-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387525PMC
February 2019
21 Reads

Preservation of allograft bone using a glycerol solution: a compilation of original preclinical research.

Biomater Res 2019 13;23. Epub 2019 Feb 13.

LifeNet Health, 1864 Concert Drive, Virginia Beach, VA 23453 USA.

Background: Bone allografts are used in many orthopedic procedures to provide structural stability as well as an osteoconductive matrix for bone ingrowth and fusion. Traditionally, bone allografts have been preserved by either freezing or freeze-drying. Each of these preservation methods has some disadvantages: Frozen grafts require special shipping and storage conditions, and freeze-drying requires special lyophilization equipment and procedures that may impact biomechanical integrity. Read More

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http://dx.doi.org/10.1186/s40824-019-0154-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373109PMC
February 2019
21 Reads

Comparative studies on thin polycaprolactone-tricalcium phosphate composite scaffolds and its interaction with mesenchymal stem cells.

Biomater Res 2019 3;23. Epub 2019 Jan 3.

Department of Chemical and Biomolecular Engineering, Seoul, 01811 Republic of Korea.

Background: Hybrid scaffolds combining biodegradable polymers and ceramic particles for control of cell adhesion and proliferation are interesting materials for tissue engineering applications. Combinations of biodegradable polymers and ceramics are to provide higher beneficial functionalities to tissue engineering scaffolds with addition of different cell specific bio-factors. Many such hybrid combinations have been reported by several researchers around the world by using various methods and solvents as well as bioactive matrix polymers to fabricate such biomaterials. Read More

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http://dx.doi.org/10.1186/s40824-018-0153-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318878PMC
January 2019
1 Read

3D printable hyaluronic acid-based hydrogel for its potential application as a bioink in tissue engineering.

Biomater Res 2019 6;23. Epub 2019 Feb 6.

3Department of Mechanical System Design Engineering, Seoul National University of Science and Technology, Seoul, 01811 Republic of Korea.

Background: After recognition of 3D printing and injectable hydrogel as a critical issue in tissue/organ engineering and regenerative medicine society, many hydrogels as bioinks have been developed worldwide by using polymeric biomaterials such as gelatin, alginate, hyaluronic acid and others. Even though some gels have shown good performances in 3D bioprinting, still their performances do not meet the requirements enough to be used as a bioink in tissue engineering.

Method: In this study, a hydrogel consisting of three biocompatible biomaterials such as hyaluronic acid (HA), hydroxyethyl acrylate (HEA) and gelatin-methacryloyl, i. Read More

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http://dx.doi.org/10.1186/s40824-018-0152-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364434PMC
February 2019
4 Reads

Bioactive calcium phosphate materials and applications in bone regeneration.

Biomater Res 2019 14;23. Epub 2019 Jan 14.

1Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 152-742 Republic of Korea.

Background: Bone regeneration involves various complex biological processes. Many experiments have been performed using biomaterials in vivo and in vitro to promote and understand bone regeneration. Among the many biomaterials, calcium phosphates which exist in the natural bone have been conducted a number of studies because of its bone regenerative property. Read More

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http://dx.doi.org/10.1186/s40824-018-0149-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332599PMC
January 2019
5 Reads

Cosmeceutical activities of ethanol extract and its ethyl acetate fraction from coffee silverskin.

Biomater Res 2019 14;23. Epub 2019 Jan 14.

Department of Fine Chemistry, Cosmetic R&D center, Cosmetic Industry Coupled Collaboration Center, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul, 01811 Korea.

Background: Coffee silverskin is a thin film that covers the raw coffee bean. In general, coffee silverskin, which detaches during the coffee roasting process, is disposed as firelighters or dispatched to landfills and can cause serious environmental pollution. The aim of this study was to investigate the feasibility of using coffee silverskin as a functional material in cosmetics by evaluating its bioactive ingredients, antioxidative activity, cytoprotective effect, matrix metalloproteinase-1 (MMP-1)-inhibiting effect, and anti-melanogenesis effect. Read More

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http://dx.doi.org/10.1186/s40824-018-0151-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332556PMC
January 2019
28 Reads

Application of Bonelike® as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases.

Biomater Res 2018 29;22:38. Epub 2018 Dec 29.

2Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.

Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s40824-018-0150-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310926PMC
December 2018
35 Reads

Silicone breast implant modification review: overcoming capsular contracture.

Biomater Res 2018 20;22:37. Epub 2018 Dec 20.

3Interdisciplinary Program for Bioengineering, College of Engineering, Seoul National University, Seoul, 08826 Republic of Korea.

Background: Silicone implants are biomaterials that are frequently used in the medical industry due to their physiological inertness and low toxicity. However, capsular contracture remains a concern in long-term transplantation. To date, several studies have been conducted to overcome this problem. Read More

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http://dx.doi.org/10.1186/s40824-018-0147-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302391PMC
December 2018
4 Reads

Recent advances in stem cell therapeutics and tissue engineering strategies.

Biomater Res 2018 19;22:36. Epub 2018 Dec 19.

1Department of Physiology, Pusan National University School of Medicine, Yangsan, 50612 Gyeongsangnam-do Republic of Korea.

Background: Tissue regeneration includes delivering specific types of cells or cell products to injured tissues or organs for restoration of tissue and organ function. Stem cell therapy has drawn considerable attention since transplantation of stem cells can overcome the limitations of autologous transplantation of patient's tissues; however, it is not perfect for treating diseases. To overcome the hurdles associated with stem cell therapy, tissue engineering techniques have been developed. Read More

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http://dx.doi.org/10.1186/s40824-018-0148-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299977PMC
December 2018
5 Reads

Calcium release and physical properties of modified carbonate apatite cement as pulp capping agent in dental application.

Biomater Res 2018 6;22:35. Epub 2018 Dec 6.

3Department of Mechanical Engineering and Engineering Science, The University of North Carolina at Charlotte, Charlotte, NC USA.

Background: Carbonate apatite (COAp) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, COAp induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s40824-018-0146-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282351PMC
December 2018
29 Reads

Recent updates for biomaterials used in total hip arthroplasty.

Biomater Res 2018 5;22:33. Epub 2018 Dec 5.

Center for Joint Disease, Chonnam National University Hwasun Hospital, 160, Ilsim-Ri, Hwasun-Eup, Hwasun-Gun, Jeonnam 519-809 South Korea.

Background: Total hip arthroplasty (THA) is probably one of the most successful surgical interventions performed in medicine. Through the revolution of hip arthroplasty by principles of low friction arthroplasty was introduced by Sir John Charnley in 1960s. Thereafter, new bearing materials, fixation methods, and new designs has been improved. Read More

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http://dx.doi.org/10.1186/s40824-018-0144-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280401PMC
December 2018
1 Read

Mitochondria-targeting theranostics.

Authors:
Han Chang Kang

Biomater Res 2018 8;22:34. Epub 2018 Nov 8.

Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662 Republic of Korea.

Background: Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing side effects, as well as the significance of theranostics for delivering therapeutics at the correct locations and doses for diseases throughout diagnosis. Among organelles, mitochondria have received substantial attention due to their significant controlling functions in cells.

Main Body: With the necessity of subcellular organelle-targeting drug delivery and theranostics, examples of mitochondria-targeting moieties and types of mitochondria-targeting theranostics were introduced. Read More

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http://dx.doi.org/10.1186/s40824-018-0145-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225566PMC
November 2018
1 Read

Nanoengineered, cell-derived extracellular matrix influences ECM-related gene expression of mesenchymal stem cells.

Biomater Res 2018 5;22:32. Epub 2018 Oct 5.

Department of Bio and Brain Engineering, KAIST, Daejeon, 34141 South Korea.

Background: Human mesenchymal stem cells (hMSCs) are, due to their pluripotency, useful sources of cells for stem cell therapy and tissue regeneration. The phenotypes of hMSCs are strongly influenced by their microenvironment, in particular the extracellular matrix (ECM), the composition and structure of which are important in regulating stem cell fate. In reciprocal manner, the properties of ECM are remodeled by the hMSCs, but the mechanism involved in ECM remodeling by hMSCs under topographical stimulus is unclear. Read More

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https://biomaterialsres.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s40824-018-0141-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173882PMC
October 2018
39 Reads

Application of black phosphorus nanodots to live cell imaging.

Biomater Res 2018 4;22:31. Epub 2018 Oct 4.

2Department of Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan, 46241 Republic of Korea.

Background: Black phosphorus (BP) has emerged as a novel class of nanomaterials owing to its unique optical and electronic properties. BP, a two-dimensional (2D) nanomaterial, is a structure where phosphorenes are stacked together in layers by van der Waals interactions. However, although BP nanodots have many advantages, their biosafety and biological effect have not yet been elucidated as compared to the other nanomaterials. Read More

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http://dx.doi.org/10.1186/s40824-018-0142-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172722PMC
October 2018
4 Reads

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer.

Biomater Res 2018 26;22:30. Epub 2018 Sep 26.

1Department of Organic Materials Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea.

Background: Mucoadhesive polymers, which may increase the contact time between the polymer and the tissue, have been widely investigated for pharmaceutical formulations. In this study, we developed a new polysaccharide-based mucoadhesive polymer with thermogelling properties.

Methods: Hexanoyl glycol chitosan (HGC), a new thermogelling polymer, was synthesized by the chemical modification of glycol chitosan using hexanoic anhydride. Read More

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http://dx.doi.org/10.1186/s40824-018-0137-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158885PMC
September 2018
17 Reads