1,939 results match your criteria Biomaterials Science[Journal]


Theranostic supramolecular polymers formed by the self-assembly of a metal-chelating prodrug.

Biomater Sci 2020 Jul 10. Epub 2020 Jul 10.

Department of Chemical and Biomolecular Engineering, and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA. and Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, Maryland 21231, USA and Department of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Therapeutic constructs with imaging modalities hold great promise for improving the treatment efficacy for cancer and many other diseases. We report here the design and synthesis of a self-assembling prodrug (SAPD) by the direct linkage of camptothecin (CPT), an anticancer drug, to a metal-chelating agent, DOTA. We found that under physiological conditions the DOTA-conjugated CPT prodrug can self-assemble into tubular supramolecular polymers (SPs) with a length of several micrometers. Read More

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http://dx.doi.org/10.1039/d0bm00827cDOI Listing

An RGD modified water-soluble fluorophore probe for in vivo NIR-II imaging of thrombosis.

Biomater Sci 2020 Jul 10. Epub 2020 Jul 10.

Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.

Venous thrombosis leads to severe symptoms and death through pulmonary embolism. There is a great need for high sensitivity imaging methods to identify acute patients who would benefit from thrombolysis. We designed a novel, organic near-infrared second-window (NIR-II) probe, which targets the glycoprotein IIb/IIIa receptor (GPIIb/IIIa) on activated platelets. Read More

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http://dx.doi.org/10.1039/d0bm00729cDOI Listing

Lithium silicate-based bioceramics promoting chondrocyte maturation by immunomodulating M2 macrophage polarization.

Biomater Sci 2020 Jul 10. Epub 2020 Jul 10.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. zhuyufang

Articular cartilage lesions occur frequently but unfortunately the damaged cartilage has a very limited intrinsic repair capacity. Since the cartilage damage can cause sterile inflammation, the effects of inflammation on cartilage repair should be well understood for precise treatment. Our previous study showed that bioceramics play an important role in cartilage regeneration. Read More

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http://dx.doi.org/10.1039/d0bm00450bDOI Listing

A novel knitted scaffold made of microfiber/nanofiber core-sheath yarns for tendon tissue engineering.

Biomater Sci 2020 Jul 10. Epub 2020 Jul 10.

Department of Sports Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Tendon injury is common in sports and other rigorous activities, which may result in dysfunction and disability. Recently, scaffolds with a knitted structure have been widely applied for tendon tissue engineering. The purpose of this study was to fabricate a novel knitted tendon scaffold made of microfiber/nanofiber core-sheath yarns and evaluate the biocompatibility and the effect of tenogenic differentiation and tendon tissue regeneration in vitro and in vivo. Read More

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http://dx.doi.org/10.1039/d0bm00816hDOI Listing

A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy.

Biomater Sci 2020 Jul 10. Epub 2020 Jul 10.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China.

We herein explored a smart Fe-HPPy@Au/DOX theranostic agent for CT diagnosis and PTT/chemotherapy/CDT synergistic treatment of cancer. When the Fe-HPPy@Au/DOX theranostic agent entered the tumor, the tumor environment accelerated the trapped Fe ions release to catalyze the production of ˙OH for CDT. NIR irradiation drove the PTT, and at the same time improved the CDT by increasing the production of ˙OH and triggered DOX release for chemotherapy. Read More

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http://dx.doi.org/10.1039/d0bm00623hDOI Listing

Current understanding of intimal hyperplasia and effect of compliance in synthetic small diameter vascular grafts.

Biomater Sci 2020 Jul 9. Epub 2020 Jul 9.

Department of Chemical engineering, University of Waterloo, 200 University Ave W, Waterloo, ON N2L 3G1, Canada. and Waterloo Institute for Nanotechnology, University of Waterloo, Canada and Centre for Biotechnology and Bioengineering, University of Waterloo, Canada.

Despite much effort, synthetic small diameter vascular grafts still face limited success due to vascular wall thickening known as intimal hyperplasia (IH). Compliance mismatch between graft and native vessels has been proposed to be one of a key mechanical factors of synthetic vascular grafts that could contribute to the formation of IH. While many methods have been developed to determine compliance both in vivo and in vitro, the effects of compliance mismatch still remain uncertain. Read More

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http://dx.doi.org/10.1039/d0bm00226gDOI Listing

Recent advances in improving tumor-targeted delivery of imaging nanoprobes.

Biomater Sci 2020 Jul 8. Epub 2020 Jul 8.

School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia. and Australian Centre for NanoMedicine (ACN), University of New South Wales, Sydney, NSW 2052, Australia.

Tumor-targeted delivery of imaging nanoprobes provides a promising approach for the precision imaging diagnosis of cancers. Nanoprobes with desired bio-nano interface properties can preferably enter tumor tissues through the vascular endothelium, penetrate into deep tissues, and detect target lesions. Surface engineering of nanoparticles offers a critical strategy to improve tumor-targeting capacities of nanoprobes. Read More

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http://dx.doi.org/10.1039/d0bm00761gDOI Listing

Correction: Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation.

Biomater Sci 2020 Jul 8. Epub 2020 Jul 8.

Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, P. R. China. and Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, P. R. China.

Correction for 'Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation' by Zongren Zhao et al., Biomater. Sci. Read More

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http://dx.doi.org/10.1039/d0bm90060eDOI Listing

Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases.

Biomater Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Chemistry & Biochemistry, The University of Texas at El Paso, USA.

With an aging population that has been increasing in recent years, the need for the development of therapeutic approaches for treatment of neurodegenerative disorders (ND) has increased. ND, which are characterized by the progressive loss of the structure or function of neurons, are often associated with neuronal death. In spite of screening numerous drugs, currently there is no specific treatment that can cure these diseases or slow down their progression. Read More

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http://dx.doi.org/10.1039/d0bm00809eDOI Listing

Catalytic rhodium (Rh)-based (mesoporous polydopamine) MPDA nanoparticles with enhanced phototherapeutic efficiency for overcoming tumor hypoxia.

Biomater Sci 2020 Jul 7. Epub 2020 Jul 7.

School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510006, PR China.

Catalytic nanomedicine with high oxygen-generation efficiency may find applications in alleviating tumor hypoxia and improving the efficiency of photodynamic therapy (PDT). In this study, a catalytic nanosystem (Ce6-Rh@MPDA) was developed using mesoporous polydopamine nanoparticles (MPDA) to encapsulate catalase-like rhodium nanoparticles (Rh NPs) and photosensitizer chlorine6 (Ce6) for photoacoustic/fluorescence dual imaging-guided tumor therapy. The Rh NPs can catalyze the production of O2 from tumor-enriched H2O2 in situ, in which the mesoporous structure of MPDA plays an important role via improving the catalytic efficiency of Rh NPs. Read More

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http://dx.doi.org/10.1039/d0bm00625dDOI Listing

Prevascularized, multiple-layered cell sheets of direct cardiac reprogrammed cells for cardiac repair.

Biomater Sci 2020 Jul 6. Epub 2020 Jul 6.

School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Republic of Korea. and Institute of Chemical Processes, BIOMAX, and Engineering Research Institute, Seoul National University, Seoul, 08826, Republic of Korea.

We previously demonstrated that the efficiency of direct cardiac reprogramming from fibroblasts could be enhanced via mimicking of the in vivo cardiac microenvironment through coculture with cardiomyocytes and by providing electric cues. In the present study, we developed cell sheets using the direct cardiac reprogrammed cells and a nanothin, nanoporous poly(lactic-co-glycolic acid) membrane. Cell sheets were laid layer-by-layer and prevacularized with endothelial cells between the layers. Read More

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http://dx.doi.org/10.1039/d0bm00701cDOI Listing

Strontium-substituted hydroxyapatite grown on graphene oxide nanosheet-reinforced chitosan scaffold to promote bone regeneration.

Biomater Sci 2020 Jul 6. Epub 2020 Jul 6.

Guangdong Key Lab of Orthopedic Technology and Implant, General Hospital of Southern Theater Command of PLA, 111 Liuhua Road, Guangzhou, 510010, China.

The strontium-substituted hydroxyapatite (SrHA) is a commonly used material in bone regeneration for its good osteoconductivity and high alkaline phosphatase (ALP) activity. Scaffolds used in bone defects require a high compressive modulus. However, the SrHA nanoparticle-doped scaffold cannot properly fit the required mechanical properties. Read More

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http://dx.doi.org/10.1039/d0bm00523aDOI Listing

Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity.

Biomater Sci 2020 Jul 6. Epub 2020 Jul 6.

State Key Laboratory of Analytical Chemistry for Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Stimuli-responsive in situ self-assembly of small molecule probes into nanostructures has been promising for the construction of molecular probes for in vivo imaging. In the past few years, a number of intelligent molecular imaging probes with fluorescence, magnetic resonance imaging (MRI), positron electron tomography (PET) or photoacoustic imaging (PA) modality have been developed based on the in situ self-assembly strategy. In this minireview, we summarize the recent advances in the development of different modality imaging probes through controlling in situ self-assembly for in vivo imaging of enzymatic activity. Read More

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http://dx.doi.org/10.1039/d0bm00895hDOI Listing

Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway.

Biomater Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Spine Surgery, Beijing JiShuiTan Hospital, Peking University, Beijing 100035, China.

Numerous studies have reported that hydroxyapatite nanoparticles (nano-HAPs) can inhibit the proliferation of a variety of tumor cells and this effect is different in different carcinoma cells. However, the effect of nano-HAPs on osteosarcoma cell proliferation has not been well understood thus far. In this study, we first showed that our synthesized nano-HAPs reduced cell viability and inhibited migration and invasion of OS-732 cells in a concentration-dependent manner. Read More

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http://dx.doi.org/10.1039/d0bm00898bDOI Listing

The antibacterial and antibiofilm activities of mesoporous hollow FeO nanoparticles in an alternating magnetic field.

Biomater Sci 2020 Jul 3. Epub 2020 Jul 3.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China. and Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan 430070, PR China.

Unrestricted usage of antibiotics has accelerated the emergence of new strains of microorganisms with antimicrobial resistance (AMR) and the development of therapeutic technologies that do not rely only on antibiotics. Herein, mesoporous hollow Fe3O4 nanoparticles (MHFPs) were synthesized by a one-pot hydrothermal method, and the feasibility and possible mechanism of using alternating magnetic field (AMF) with MHFPs to kill Escherichia coli (E. coli) and Staphylococcus aureus (S. Read More

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http://dx.doi.org/10.1039/d0bm00673dDOI Listing

Intravenous anti-VEGF agents with RGD peptide-targeted core cross-linked star (CCS) polymers modified with indocyanine green for imaging and treatment of laser-induced choroidal neovascularization.

Biomater Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, 200072, China.

Age-related macular degeneration (AMD) is a leading cause of irreversible visual loss among elderly persons, of which wet AMD is characterized by choroidal neovascularization (CNV). We herein developed nanoparticles with good biosafety for effective treatment of choroidal neovascularization (CNV). S-PEG-ICG-RGD-RBZ NPs were synthesized and characterized by ZP, DLS, UV-Vis, TEM and Coomassie Brilliant Blue staining analyses. Read More

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http://dx.doi.org/10.1039/c9bm02086aDOI Listing

Injectable hydrogels based on MPEG-PCL-RGD and BMSCs for bone tissue engineering.

Biomater Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul 06591, Republic of Korea. and Institute of Cell and Tissue Engineering, The Catholic University of Korea, Seoul 06591, Republic of Korea and Department of Medical Life Sciences College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

The aim of this study was to investigate the osteogenic potential of bone marrow-derived mesenchymal stem cells (BMSCs) seeded on novel thermosensitive in situ forming hydrogel systems comprising methoxy polyethylene glycol-polycaprolactone (MP) and RGD-conjugated MP (MP-RGD) in vitro and in vivo. Real-time polymerase chain reaction (PCR) together with immunofluorescence staining revealed the strong expression of osteogenic markers (collagen 1 and osteocalcin) of BMSCs in MP/MP-RGD samples compared to MP samples. PCR array testing also showed the upregulation of the interconnected signaling networks regulating cell proliferation and differentiation, which was further verified through the Kyoto Encyclopedia of Genes and Genomes pathway analysis. Read More

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http://dx.doi.org/10.1039/d0bm00588fDOI Listing

Silk degumming time controls horseradish peroxidase-catalyzed hydrogel properties.

Biomater Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Biomedical Engineering, Tufts University, 4 Colby St, Medford, MA 02155, USA.

Hydrogels provide promising applications in tissue engineering and regenerative medicine, with silk fibroin (SF) offering biocompatibility, biodegradability and tunable mechanical properties. The molecular weight (MW) distribution of SF chains varies from ∼80 to 400 kDa depending on the extraction and purification process utilized to prepare the protein polymer. Here, we report a fundamental study on the effect of different silk degumming (extraction) time (DT) on biomaterial properties of enzymatically crosslinked hydrogels, including secondary structure, mechanical stiffness, in vitro degradation, swelling/contraction, optical transparency and cell behaviour. Read More

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http://dx.doi.org/10.1039/d0bm00512fDOI Listing

Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis.

Biomater Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

Clinically available prosthetic heart valves are life-saving, but imperfect: mechanical valves requiring anticoagulation therapy, whilst bioprosthetic valves have limited durability. Polymer valves offer the prospect of good durability without the need for anticoagulation. We report the design and development of a polymeric heart valve, its bench-testing at ISO standards, and preliminary extra-vivo and in vivo short-term feasibility. Read More

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http://dx.doi.org/10.1039/d0bm00412jDOI Listing

mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.

Biomater Sci 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery, Guangzhou First People's Hospital, School of Medicine and Institutes for Life Sciences, South China University of Technology, Guangzhou 510006, China. and Key Laboratory of Biomedical Engineering of Guangdong Province, and Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China.

A great variety of nanoparticles are known to induce autophagy, leading to either pro-death or pro-survival. Zeolitic imidazolate framework-8 (ZIF-8), a type of porous metal-organic framework (MOF) material and a promising drug delivery vector, has reportedly shown excellent efficacy for cancer therapy. However, less attention has been paid to the potential biological effect of ZIF-8 per se, and if so, how the effect impacts cell fate and therapy outcomes. Read More

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http://dx.doi.org/10.1039/d0bm00773kDOI Listing

Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation.

Biomater Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Chemical and Biological Engineering, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA. and The BioFrontiers Institute, University of Colorado Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA.

Chondrocyte deformation influences disease progression and tissue regeneration in load-bearing joints. In this work, we found that viscoelasticity of dynamic covalent crosslinks temporally modulates the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes. Chondrocytes in viscoelastic alky-hydrazone hydrogels demonstrated (91. Read More

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http://dx.doi.org/10.1039/d0bm00860eDOI Listing

Biocompatible melanin based theranostic agent for in vivo detection and ablation of orthotopic micro-hepatocellular carcinoma.

Biomater Sci 2020 Jun 30. Epub 2020 Jun 30.

Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, PR China.

Early diagnosis and therapy of hepatocellular carcinoma (HCC) is critical to improve the five-year survival rates of patients. Theranostic agents synergized with photothermal ablation are expected to realize the early detection and treatment of orthotopic HCC. However, conventional metallic nanoagents are limited by their potential bio-toxicity to surrounding normal organs. Read More

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http://dx.doi.org/10.1039/d0bm00825gDOI Listing

A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties.

Biomater Sci 2020 Jun 30. Epub 2020 Jun 30.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P.R. China. and State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China.

Bioadhesives are of great interest for tissue/wound closure to reduce surgical time, minimize treatment invasiveness, and prevent body fluid leakage. However, bacterial infections remain a major concern during wound healing and tissue bonding. Hence, the development of bioadhesives with antibacterial properties is necessary. Read More

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http://dx.doi.org/10.1039/d0bm00624fDOI Listing

A thermosensitive nanoplatform for photoacoustic imaging and NIR light triggered chemo-photothermal therapy.

Biomater Sci 2020 Jun 29. Epub 2020 Jun 29.

Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, P.R. China. and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P.R. China.

Temperature-sensitive liposomes (TSLs) have received constant attention due to the release of contents around the physiological temperature, which holds great potential in the treatment of tumors. However, the development of TSLs is limited by the long-term biotoxicity and low photothermal conversion efficiency of heat-generation materials. In this study, we develop a new D-A (donor-acceptor) structure NIR absorbing dye (C720) which exhibits a high photothermal conversion efficiency (62%), good photostability, and photothermal reproducibility. Read More

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http://dx.doi.org/10.1039/d0bm00810aDOI Listing

Rapamycin-PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mouse joints.

Biomater Sci 2020 Jun 29. Epub 2020 Jun 29.

Centre for BioSystems Science and Engineering, Indian Institute of Science, Bengaluru, 560012 India.

Osteoarthritis (OA) is a joint disease characterized by progressive damage of articular cartilage and the adjoining subchondral bone. Chondrocytes, the primary cells of the cartilage, have limited regenerative capacity and when they undergo stress due to trauma or with aging, they senesce or become apoptotic. Rapamycin, a potent immunomodulator, has shown promise in OA treatment. Read More

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http://dx.doi.org/10.1039/d0bm00596gDOI Listing

Three dimensional printed degradable and conductive polymer scaffolds promote chondrogenic differentiation of chondroprogenitor cells.

Biomater Sci 2020 Jun 26. Epub 2020 Jun 26.

School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK. and Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD, UK.

Conductive polymers have been used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability and brittleness of these polymers hinder the fabrication of three-dimensional structures with desirable geometries. Moreover, their application in tissue engineering and regenerative medicine has been so far limited to excitable cells such as neurons and muscle cells. Read More

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http://dx.doi.org/10.1039/d0bm00621aDOI Listing

Improved synergic therapeutic effects of chemoradiation therapy with the aid of a co-drug-loaded nano-radiosensitizer under conventional-dose X-ray irradiation.

Biomater Sci 2020 Jun 26. Epub 2020 Jun 26.

Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. and Department of pharmaceutical biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

The goal of this work is to harness the advantages of a targeted hybrid nanostructure, BSA-coated Fe3O4 (F)-Au heterodimer, as a radiosensitizer and co-delivery vehicle of chemotherapeutic drugs for enhanced synergic cancer therapy and protection of healthy tissues. F-Au-BSA-MTX-CUR combines the abilities of enhanced X-ray radiation therapy (F-Au), long blood circulation time (BSA), tumor targeting (MTX), enhanced chemotherapy (MTX and CUR), and protection of normal cells against the harmful effects of radiation (CUR). In this work, we present the radioprotective and radiosensitizing effects of CUR on normal tissues and the tumor site, respectively. Read More

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http://dx.doi.org/10.1039/d0bm00353kDOI Listing

A bifunctional nanoplatform based on copper manganate nanoflakes for bacterial elimination via a catalytic and photothermal synergistic effect.

Biomater Sci 2020 Jun 26. Epub 2020 Jun 26.

College of Food Science and Engineering, Northwest A&F University, Yangling712100, Shaanxi, China.

Bacterial infection has been recognized as one of the greatest threats to public health. In view of the continuous increase of bacterial resistance, constructing a collaborative bactericidal platform is a promising strategy to enhance the efficiency of antimicrobial agents. Herein, we report a facile, biocompatible and versatile nano-platform based on positively charged copper manganate nanoflakes (CuMnO2 NFs), which exhibits intrinsic peroxidase-like catalytic activity and excellent photothermal properties. Read More

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http://dx.doi.org/10.1039/d0bm00706dDOI Listing

Preparation of a size selective nanocomposite through temperature assisted co-assembly of gelatin and pluronic F127 for passive targeting of doxorubicin.

Biomater Sci 2020 Jun 25. Epub 2020 Jun 25.

Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai-400085, India. and Homi Bhabha National Institute, Anushaktinagar, Mumbai-400094, India.

The preparation of a water dispersible and pH responsive gelatin-F127 nanocomposite using a thermal relaxation approach is reported. The results indicated that physical properties (size and surface charge) of the gelatin-F127 nanoparticle can be tuned by varying the F127 to gelatin weight ratio. The heating (60 °C) of a saline solution (pH 7. Read More

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http://dx.doi.org/10.1039/d0bm00725kDOI Listing

Tough and injectable fiber reinforced calcium phosphate cement as an alternative to polymethylmethacrylate cement for vertebral augmentation: a biomechanical study.

Biomater Sci 2020 Jun 24. Epub 2020 Jun 24.

Radboud University Medical Center, Radboud Institute for Molecular Life Sciences; Department of Dentistry - Regenerative Biomaterials, Philips van Leydenlaan 25, Nijmegen, The Netherlands.

Vertebral compression fractures (VCFs) are a very common problem among the elderly, which ultimately result in severe pain and a drastically reduced quality of life. An effective treatment for VCFs is the minimally invasive augmentation of the damaged vertebrae through vertebroplasty and/or kyphoplasty. These surgical procedures treat the affected vertebrae by injection of poly(methyl methacrylate) cement (PMMA) into the vertebral body. Read More

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http://dx.doi.org/10.1039/d0bm00413hDOI Listing

The rapid photoresponsive bacteria-killing of Cu-doped MoS.

Biomater Sci 2020 Jun 24. Epub 2020 Jun 24.

The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China.

Bacterial infection is a serious public health issue because this may cause bacterial pneumonia and bacteria-infected sepsis. The conventional antibiotic therapy can cause bacterial resistance and other adverse effects. Herein, we designed a novel photoresponsive hybrid, in which MoS2 nanosheets were doped with copper ions (MoS2@Cu2+). Read More

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http://dx.doi.org/10.1039/d0bm00872aDOI Listing

Liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats promote angiogenesis to accelerate diabetic wound healing via the modulation of miR-29b-3p.

Biomater Sci 2020 Jun 24. Epub 2020 Jun 24.

Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Diabetic wounds remain a serious clinical challenge whereas current therapies have limited effects on reducing the high disability and morbidity. Impaired vascularization is closely associated with delayed healing of diabetic wounds and liraglutide (Lira), a GLP-1R receptor agonist, has been reported to promote the angiogenic ability of endothelial cells. However, its application is hindered owing to the unsustainable drug concentration. Read More

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http://dx.doi.org/10.1039/d0bm00442aDOI Listing

New strategy for precise cancer therapy: tumor-specific delivery of mitochondria-targeting photodynamic therapy agents and in situ O-generation in hypoxic tumors.

Biomater Sci 2020 Jun 23. Epub 2020 Jun 23.

College of Chemistry and Materials Science, Nanjing Normal University, China.

Besides tumor hypoxia and limitation of superficial lesions, the short lifetime of photoinduced reactive oxygen species (ROS) is another factor repressing photodynamic therapy (PDT) efficacy. To overcome these problems, this study developed newly designed mitochondria-specific, H2O2-activatable, and O2-producing nanoparticles to achieve highly selective and efficient PDT and self-sufficiency of O2 in hypoxic tumors. The newly designed nanoparticles (BDPP NPs) are composed of a mitochondria-targeting photosensitizer and catalase in the aqueous core and a black hole quencher and fluorescent tracker in the polymeric shell, and modified with the tumor-targeting cyclic pentapeptide c(RGDfK). Read More

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http://dx.doi.org/10.1039/d0bm00500bDOI Listing

The effects of silk layer-by-layer surface modification on the mechanical and structural retention of extracellular matrix scaffolds.

Biomater Sci 2020 Jun 23. Epub 2020 Jun 23.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China. and Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China.

Naturally derived extracellular matrix scaffolds can effectively promote tissue repair and regeneration due to their remarkable bioactivity. However, their rapid degradation leads to the decrease of mechanical retention and the failure of physical support in vivo which limit their applications. In this paper, we modified a classic extracellular matrix scaffold - small intestinal submucosa (SIS) - by a silk fibroin (SF) layer-by-layer (LbL) assembly to replace the existing chemical crosslinking methods for improving its mechanical and structural stability. Read More

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http://dx.doi.org/10.1039/d0bm00448kDOI Listing

Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation.

Biomater Sci 2020 Jun 23. Epub 2020 Jun 23.

Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, P. R. China. and Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, P. R. China.

Glioma is the most aggressive primary malignant brain tumor. The eradication of the gliomas by performing neurosurgery has not been successful due to the diffuse nature of malignant gliomas. Temozolomide (TMZ) is the first-line agent in treating gliomas after surgery, and its therapeutic efficacy is limited mainly due to the high activity levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) in glioma cells. Read More

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http://dx.doi.org/10.1039/d0bm00338gDOI Listing

Bioactive, degradable and multi-functional three-dimensional membranous scaffolds of bioglass and alginate composites for tissue regenerative applications.

Biomater Sci 2020 Jun 23. Epub 2020 Jun 23.

National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy Campus, Chennai - 600 025, India.

With a worldwide increase in the aged populace and associated geriatric diseases, there is an enormous need for the regeneration of degenerated organ systems. For this purpose, bioactive glass particulate (nBG) integrated alginate (Alg) composite membrane scaffolds were fabricated by a sol-gel assisted freeze-drying method and validated for their multifunctional utility in regenerative medicine. The presence of the combeite highly crystalline structure of nBG and Alg amorphous broad peaks were confirmed. Read More

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http://dx.doi.org/10.1039/d0bm00714eDOI Listing

Bioreducible, branched poly(β-amino ester)s mediate anti-inflammatory ICAM-1 siRNA delivery against myocardial ischemia reperfusion (IR) injury.

Biomater Sci 2020 Jun 23. Epub 2020 Jun 23.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou 215123, China.

siRNA-mediated RNA interference (RNAi) against inflammation-related genes provides a promising modality for the treatment of myocardial ischemia reperfusion (IR) injury, and its success is critically dependent on the development of efficient yet safe siRNA delivery vehicles. Herein, we developed a bioreducible, branched poly(β-amino ester) with built-in redox-responsive domains (BPAE-SS) for the effective ICAM-1 siRNA delivery into injured rat cardiac microvascular endothelial cells (RCMECs). The branched BPAE-SS with a multivalent structure afforded potent siRNA binding affinity compared to its linear analogue, while upon internalization into RCMECs it was instantaneously degraded by intracellular glutathione (GSH) into small segments to mediate "on-demand" siRNA release and diminish the toxicity of post-transfection materials. Read More

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http://dx.doi.org/10.1039/d0bm00631aDOI Listing

Cholesterol moieties as building blocks for assembling nanoparticles to achieve effective oral delivery of insulin.

Biomater Sci 2020 Jun 23. Epub 2020 Jun 23.

Department of Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 211198, P. R. China.

Although nanoparticles (NPs) have emerged as a promising strategy to improve oral absorption of insulin, most of them still have minimal oral bioavailability due to the harsh gastrointestinal (GI) environment and epithelial barriers. A novel platform of oral insulin delivery is herein proposed based on amphiphilic cholesterol-phosphate conjugate (CHP). The CHP was synthesized with a cholesterol moiety as a hydrophobic block and a phosphate group as a hydrophilic block. Read More

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http://dx.doi.org/10.1039/d0bm00577kDOI Listing

In vivo performance of gold nanoparticle-loaded absorbable inferior vena cava filters in a swine model.

Biomater Sci 2020 Jun 19. Epub 2020 Jun 19.

Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. and MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, 6767 Bertner Ave., Houston, TX 77030, USA.

Absorbable inferior vena cava filters (IVCFs) offer a promising alternative to metallic retrievable filters in providing protection against pulmonary embolism (PE) for patients contraindicated for anticoagulant therapy. However, because absorbable filters are not radiopaque, monitoring of the filter using conventional X-ray imaging modalities (e.g. Read More

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http://dx.doi.org/10.1039/d0bm00414fDOI Listing

Synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic OEG and reducibly conjugated CPT for controlled release.

Biomater Sci 2020 Jun 18. Epub 2020 Jun 18.

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Department of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China and State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.

Fabrication of cyclic graft (cg) copolymer-based polymeric prodrugs by conjugation of drug molecules to cg copolymers via a dynamic covalent bond capable of responding to biorelevant signals integrates simultaneously the merits of cg copolymers and polymeric prodrugs for enhanced stability of nanocarriers and precise modulation of drug release kinetics. To completely eliminate the compromised drug conjugation efficiency due to the steric hindrance of hydrophilic grafts, it will be useful to develop cg polymeric prodrugs with heterogeneous grafts composed of hydrophilic polymers and drug species, respectively. For this purpose, we reported in this study the synthesis of cyclic graft polymeric prodrugs with heterogeneous grafts of hydrophilic oligo (ethylene glycol) (OEG) and reducibly conjugated camptothecin (CPT), cg-poly(oligo(ethylene glycol) monomethyl ether methacrylate)-b-poly((2-hydroxyethyl methacrylate)-disulfide link-camptothecin) (cg-P(OEGMA)-b-P(HEMA-SS-CPT), cg-prodrugs), via an integrated strategy of a previously reported diblock copolymer-based template and post-polymerization intermolecular click conjugation of a reducible CPT prodrug. Read More

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http://dx.doi.org/10.1039/d0bm00656dDOI Listing

Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy.

Biomater Sci 2020 Jun 17. Epub 2020 Jun 17.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. and Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China.

Increasing evidence indicates that the tumor microenvironment (TME) imposes various obstacles in response to chemotherapies. Sodium tanshinone IIA sulfonate (STS) has a validated ability to repair the unfavorable TME, providing a suitable environment for celastrol-based chemotherapy. However, remodeling TME still possesses enormous challenges for STS due to the difficulty in a controlled release at tumor sites. Read More

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http://dx.doi.org/10.1039/d0bm00498gDOI Listing

Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA.

Biomater Sci 2020 Jun 18. Epub 2020 Jun 18.

Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, Urbana, Illinois 61801, USA. and Civil and Environmental Engineering Department, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of disability globally. In OA, the articulating surface of cartilage is compromised by fissures and cracks, and sometimes even worn away completely. Due to its avascular nature, articular cartilage has a poor self-healing ability, and therefore, understanding the mechanisms underlying degradation is key for OA prevention and for optimal design of replacements. Read More

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http://dx.doi.org/10.1039/d0bm00496kDOI Listing

The recent advances in surface antibacterial strategies for biomedical catheters.

Biomater Sci 2020 Jun 19. Epub 2020 Jun 19.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. and University of Science and Technology of China, Hefei, 230026, P. R. China.

As one of the most common hospital-acquired infections, catheter-related infections (CRIs) which are caused by microbial colonization lead to increasing morbidity and mortality of patients and life threat for medical staffs. In this case, a variety of efforts have been made to design functional materials to limit bacterial colonization and biofilm formation. In this review, we focus on the recent advances in surface modification strategies of biomedical catheters used to prevent CRIs. Read More

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http://dx.doi.org/10.1039/d0bm00659aDOI Listing

A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles.

Biomater Sci 2020 Jun 18. Epub 2020 Jun 18.

Dpt. Molecular Sciences, Macquarie University, Sydney, NSW, Australia. and Centre for Nanoscale and BioPhotonics, Macquarie University, Sydney, NSW, Australia.

Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations. Read More

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http://dx.doi.org/10.1039/d0bm00445fDOI Listing

Hollow ferric-tannic acid nanocapsules with sustained O and ROS induction for synergistic tumor therapy.

Biomater Sci 2020 Jun 18. Epub 2020 Jun 18.

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P.R. China.

Nanoparticles presenting promoted catalytic activity, oxygen induction and loading capability are in high demand for effective synergistic tumor therapy. Herein, ferric-tannic acid complex nanocapsules with fine hollow microstructure (HFe-TA) are synthesized and loaded with a photosensitizer (indocyanine green, ICG) for synergistic tumor therapy. In acidic environment, ICG@HFe-TA decomposes and releases Fe3+ ions, TA and ICG molecules. Read More

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http://dx.doi.org/10.1039/d0bm00533aDOI Listing

Charge-conversional polyethylenimine-entrapped gold nanoparticles with I-labeling for enhanced dual mode SPECT/CT imaging and radiotherapy of tumors.

Biomater Sci 2020 Jun 18. Epub 2020 Jun 18.

Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, People's Republic of China.

Novel theranostic nanosystems demonstrate great potential to achieve timely diagnosis and effective therapy at the same time. However, due to the relatively low accumulation of theranostic nanosystems at the tumor site, the theranostic efficiency is limited. In this study, a novel theranostic nanosystem with a pH-responsive charge conversion property was constructed to improve the cellular uptake towards cancer cells for enhanced single photon emission computed tomography (SPECT)/computed tomography (CT) dual mode imaging and radiotherapy of tumors. Read More

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http://dx.doi.org/10.1039/d0bm00649aDOI Listing

Construction and application of textile-based tissue engineering scaffolds: a review.

Biomater Sci 2020 Jul 18;8(13):3574-3600. Epub 2020 Jun 18.

Key Laboratory of Textile Science and Technology of Ministry of Education and College of Textiles, Donghua University, Shanghai 201620, China.

Tissue engineering (TE) provides a practicable method for tissue and organ repair or substitution. As the most important component of TE, a scaffold plays a critical role in providing a growing environment for cell proliferation and functional differentiation as well as good mechanical support. And the restorative effects are greatly dependent upon the nature of the scaffold including the composition, morphology, structure, and mechanical performance. Read More

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http://dx.doi.org/10.1039/d0bm00157kDOI Listing

Customized hydrogel substrates for serum-free expansion of functional hMSCs.

Biomater Sci 2020 Jun 16. Epub 2020 Jun 16.

Materials Science Program, University of Wisconsin-Madison, Madison, WI, USA. and Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA and Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA.

We describe a screening approach to identify customized substrates for serum-free human mesenchymal stromal cell (hMSC) culture. In particular, we combine a biomaterials screening approach with design of experiments (DOE) and multivariate analysis (MVA) to understand the effects of substrate stiffness, substrate adhesivity, and media composition on hMSC behavior in vitro. This approach enabled identification of poly(ethylene glycol)-based and integrin binding hydrogel substrate compositions that supported functional hMSC expansion in multiple serum-containing and serum-free media, as well as the expansion of MSCs from multiple, distinct sources. Read More

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http://dx.doi.org/10.1039/d0bm00540aDOI Listing

Biologically active Camellia oleifera protein nanoparticles for improving the tumor microenvironment and drug delivery.

Biomater Sci 2020 Jun 16. Epub 2020 Jun 16.

MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, China.

It is important for antitumor drugs to accumulate at the tumor site and penetrate deeply to play a role in treatment. However, it is difficult for the drugs to reach the destination on account of the complex tumor microenvironment such as elevated tumor interstitial fluid pressure (IFP) and solid stress. Here, we report a type of nanocarrier composed entirely of Camellia oleifera protein (COP), which could lower tumor IFP and solid stress. Read More

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http://dx.doi.org/10.1039/d0bm00516aDOI Listing

Combo-targeted nanoassemblies as a chemotherapy delivery system against peritoneal carcinomatosis colorectal cancer.

Biomater Sci 2020 Jun 15. Epub 2020 Jun 15.

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan.

Peritoneal carcinomatosis colorectal cancer (pcCRC) is one of the most challenging cases in clinical treatment due to its aggressive characteristics and diagnostic limitations, impeding the therapeutic efficacy of chemotherapy. In this study, a poly(lactic-co-glycolic acid) nanoparticle (NP)-based drug delivery system capable of encapsulating the chemodrug SN38 and enhancing drug accumulation in metastatic tumors was developed for the treatment of pcCRC. The SN38-loaded NPs with a diameter of ca. Read More

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http://dx.doi.org/10.1039/d0bm00583eDOI Listing