1,108 results match your criteria Biomaterials Science[Journal]


Modulating bioactivities of primary ammonium-tagged antimicrobial aliphatic polycarbonates by varying length, sequence and hydrophobic side chain structure.

Biomater Sci 2019 Apr 24. Epub 2019 Apr 24.

Graduate School of Science and Engineering, Yamagata University, Japan.

Cationic aliphatic polycarbonates bearing primary ammonium side chains have been developed with relatively high molecular weights and controlled macromolecular architectures. These polycarbonates exhibit reasonable antimicrobial activity against Gram-negative and Gram-positive bacteria. The prepared homopolymers could be effective against Gram-negative bacteria whose growth is usually inhibited by copolymers with hydrophobic comonomer units when quaternary ammonium salts (QAS) are used at the cationic side chains. Read More

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http://dx.doi.org/10.1039/c9bm00440hDOI Listing

The theranostic nanoagent MoC for multi-modal imaging-guided cancer synergistic phototherapy.

Biomater Sci 2019 Apr 24. Epub 2019 Apr 24.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China. and Key Laboratory of Micro-systems and Micro-structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, China.

Multifunctional theranostic platforms, especially single component-based platforms, enable both cancer treatment and real-time imaging as well as enhance the efficiency of treatment. In this study, 50 nm Mo2C nanospheres were explored as a "one-for-all" theranostic agent. The light-harvesting of Mo2C covered the entire near infrared region, and NIR irradiation concurrently triggered hyperthermia and reactive oxygen species (ROS) production; thus, synergistic outcomes of photothermal and photodynamic therapy could be realized. Read More

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http://dx.doi.org/10.1039/c9bm00239aDOI Listing

Intratumoral delivery of M-CSF by calcium crosslinked polymer micelles enhances cancer immunotherapy.

Biomater Sci 2019 Apr 23. Epub 2019 Apr 23.

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China. and International Center of Future Science, Jilin University, Changchun, Jilin, China and National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China and State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin, China.

Immunotherapy has shown promising results in multiple malignancies. However, there are still significant challenges in cancer immunotherapy including the powerful immunosuppressive tumor microenvironment and adverse off-target side effects. Nanomaterials with defined physico-biochemical properties are versatile drug delivery platforms that may address these key technical challenges faced by cancer immunotherapy. Read More

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http://dx.doi.org/10.1039/c9bm00226jDOI Listing
April 2019
1 Read

Cancer cell-nanomaterial interface: role of geometry and surface charge of nanocomposites in the capture efficiency and cell viability.

Biomater Sci 2019 Apr 23. Epub 2019 Apr 23.

The Institute for Translational Nanomedicine, Shanghai East Hospital, the Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, P. R. China.

The nanomaterial-cell interface plays an important role in biodetection and therapy. Several parameters involved in the bio-nano interaction such as size, shape, surface charge, surface functionality and protein corona on the nanomaterials have been studied. Recently, we found that the surface charge of the cancer cell membrane derived from the glycolysis could be a general hallmark for cancer cell targeting and very efficient isolation by tailored nanoparticles. Read More

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http://dx.doi.org/10.1039/c9bm00037bDOI Listing

Pancreatic islet surface engineering with a starPEG-chondroitin sulfate nanocoating.

Biomater Sci 2019 Apr 23. Epub 2019 Apr 23.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.

Islet transplantation is one of the most promising therapeutic options that could restore euglycaemia in type 1 diabetic individuals. The currently implemented alginate microsphere islet encapsulation approach has led to positive outcomes in improving intraportal islet delivery in rodents. However, results obtained from human clinical trials remain disappointing. Read More

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http://xlink.rsc.org/?DOI=C9BM00061E
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http://dx.doi.org/10.1039/c9bm00061eDOI Listing
April 2019
2 Reads

Folated pH-degradable nanogels for the simultaneous delivery of docetaxel and an IDO1-inhibitor in enhancing cancer chemo-immunotherapy.

Biomater Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, PR China.

Combining chemotherapy and immunotherapy has been considered as an attractive approach to improve cancer therapy. Here we prepared folated PVA-based nanogels for the simultaneous delivery of docetaxel (DTX) and the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor NLG919 (N9) for enhancing cancer chemo-immunotherapy. FDA-approved poly(vinyl alcohol) (PVA) with good biocompatibility was modified with vinyl ether acrylate (VEA) groups for UV-crosslinking and acidic degradation. Read More

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http://dx.doi.org/10.1039/c9bm00324jDOI Listing
April 2019
1 Read

Au nanoparticles with enzyme-mimicking activity-ornamented ZIF-8 for highly efficient photodynamic therapy.

Biomater Sci 2019 Apr 17. Epub 2019 Apr 17.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

The tumor hypoxic microenvironment (THME) has a profound impact on tumor progression, and modulation of the THME has become an essential strategy to promote photodynamic therapy (PDT). Here, an oxygen self-supplied nanodelivery system that is based on nanometal-organic frameworks (nMOFs) with embedded AuNPs (Au@ZIF-8) on the nMOF surface as a catalase (CAT)-like nanozyme and encapsulating Ce6 inside as a photosensitizer was found to mitigate tumor hypoxia and reinforce PDT. As soon as Au@ZIF-8 reaches the tumor site, the AuNP nanozyme can catalyze excessive H2O2 to produce O2 to alleviate tumor hypoxia, promoting the production of 1O2 with strong toxicity toward tumor cells under irradiation. Read More

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http://dx.doi.org/10.1039/c9bm00333aDOI Listing

Zwitterionic carbon dot-encapsulating pH-responsive mesoporous silica nanoparticles for NIR light-triggered photothermal therapy through pH-controllable release.

Biomater Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea. and Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea.

Here, we designed a pH-responsive Indocyanine Green (ICG)-loaded zwitterion fluorescent carbon dot (CD)-encapsulating mesoporous silica nanoparticle (MSN) for pH-tunable image-guided photothermal therapy. ICG was loaded into MSN(CD) via hydrophobic and electrostatic interactions between zwitterionic CDs and ICG to achieve a controlled photothermal temperature with a fluorescent "off/on" system. The porosity of the MSNs was altered after ICG loading because of intermolecular interactions between the CDs and ICG inside the MSN shell and core, which blocked the MSN pore. Read More

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http://xlink.rsc.org/?DOI=C9BM00160C
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http://dx.doi.org/10.1039/c9bm00160cDOI Listing
April 2019
1 Read

Correction: The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome.

Biomater Sci 2019 Apr;7(5):2200

Department of Biomedical Engineering, Vanderbilt University, USA.

Correction for 'The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome' by Jessalyn J. Baljon et al., Biomater. Read More

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http://dx.doi.org/10.1039/c9bm90022eDOI Listing

NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway.

Biomater Sci 2019 Apr 12. Epub 2019 Apr 12.

Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China.

The photothermal response of nanomaterials provides a basis for many biomedical applications, including diagnosis (e.g., biosensor and photoacoustic imaging) and treatment (e. Read More

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http://dx.doi.org/10.1039/c8bm01007bDOI Listing
April 2019
1 Read

Thiolated γ-polyglutamic acid as a bioadhesive hydrogel-forming material: evaluation of gelation, bioadhesive properties and sustained release of KGF in the repair of injured corneas.

Biomater Sci 2019 Apr 12. Epub 2019 Apr 12.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou City, Zhejiang Province 325035, China.

Keratinocyte growth factor (KGF) has a good therapeutic effect on injured corneas. However, due to the washout of tears and blinking, locally administrated KGF usually has a short residence time on the surface of an injured cornea, resulting in its poor bioavailability. Herein, a bioadhesive hydrogel is described produced using cysteine-modified γ-polyglutamic acid (PGA-Cys) as the hydrogel-forming material to locally deliver KGF. Read More

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http://dx.doi.org/10.1039/c9bm00341jDOI Listing

Construction of cellulose nanofibers/quaternized chitin/organic rectorite composites and their application as wound dressing materials.

Biomater Sci 2019 Apr 12. Epub 2019 Apr 12.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

Traumatic injury is a major cause of mortality, and poor wound healing affects millions of people. Thus, the development of effective wound dressings is essential for speeding up wound healing and decreasing mortality. In this study, a suspension of carboxylated brown algae cellulose nanofibers (BACNFs) with a high aspect ratio was freeze dried to prepare a sponge. Read More

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http://dx.doi.org/10.1039/c9bm00288jDOI Listing
April 2019
1 Read

Relating the blood-thinning effect of pentoxifylline to the reduction in the elastic modulus of human red blood cells: an in vivo study.

Biomater Sci 2019 Apr 11. Epub 2019 Apr 11.

1st Neurology Clinic, Aristotle University of Thessaloniki, Thessaloniki, Greece.

The blood thinning properties of pentoxifylline have been attributed to its ability to increase the deformability of red blood cells and improve their rheological properties. To interpret and substantiate these observations a novel approach is taken by measuring the stiffness of individual red blood cells from healthy humans before and after subscription to pentoxifylline for nine days. Atomic force microscopy nanoindentation experiments reveal that the elastic modulus of the red blood cells decreased by 30%-40%, after pentoxifylline subscription. Read More

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http://dx.doi.org/10.1039/c8bm01691gDOI Listing

Nanoscale vesicles assembled from non-planar cyclic molecules for efficient cell penetration.

Biomater Sci 2019 Apr 11. Epub 2019 Apr 11.

MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, China.

A new approach to the development of functional biomaterials is to obtain a controllable nanostructure through supramolecular self-assembly. Although much effort has been devoted to supramolecular structures with different morphologies and properties, fluorescent macrocycle-based carbon material assembly into three-dimensional vesicle morphologies remains a challenge. Herein, the supramolecular properties of cycloparaphenylene (CPP) in a mixed solution are characterized and controlled successfully through the regulation of different concentrations and solvent ratios. Read More

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http://dx.doi.org/10.1039/c9bm00347aDOI Listing

Ceria nanoparticles promoted the cytotoxic activity of CD8 T cells by activating NF-κB signaling.

Biomater Sci 2019 Apr 10. Epub 2019 Apr 10.

Institute of Immunology, Third Military Medical University, Chongqing 400038, China.

Cytotoxic CD8+ T cells (CTLs) are crucial for controlling intracellular pathogens as well as cancer. However, how to promote the cytotoxic activity of CTL cells in vitro and in vivo remains largely unknown. On the other hand, ceria nanoparticles (CNPs) are widely used in biomedical fields, but the role of CNPs in CTL cells is still unclear. Read More

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http://dx.doi.org/10.1039/c9bm00113aDOI Listing
April 2019
1 Read

In situ synthesis, stabilization and activity of protein-modified gold nanoparticles for biological applications.

Biomater Sci 2019 Apr 10. Epub 2019 Apr 10.

Chemistry Department, Missouri State University, 901 S. National Ave, Springfield, Missouri 65897, USA.

Herein, we demonstrate the use of lysozyme (Lys) as a model to fabricate a protein carrier system based on gold nanoparticles (AuNPs) via the Layer-by-Layer (LbL) technology. Poly(ethyleneimine) (PEI) and poly(sodium 4-styrenesulfonate) (PSS) were used as cationic and anionic polymers respectively to grow oppositely charged layers. Mild aqueous conditions were utilized to avoid protein denaturation and activity instead of organic solvents that have been used in other encapsulation systems. Read More

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http://dx.doi.org/10.1039/c9bm00129hDOI Listing

Tocopherol polyethylene glycol succinate-modified hollow silver nanoparticles for combating bacteria-resistance.

Biomater Sci 2019 Apr 10. Epub 2019 Apr 10.

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.

Multiple drug resistance and the increase in the appearance of superbugs together with the exceedingly scant development of new potent antibiotic drugs pose an urgent global medical threat and imminent public security crisis. In the present study, we fabricated well-dispersed tocopherol polyethylene glycol succinate (TPGS)-capped silver nanoparticles (AgNPs) of about 10 nm in size. The hollow structure of the TPGS-capped AgNPs (TPGS/AgNPs) was confirmed and applied to load antibiotics. Read More

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http://dx.doi.org/10.1039/c9bm00343fDOI Listing
April 2019
1 Read

An extracellular pH-driven targeted multifunctional manganese arsenite delivery system for tumor imaging and therapy.

Biomater Sci 2019 Apr 8. Epub 2019 Apr 8.

Center for Interventional Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China.

Expanding the use of arsenic trioxide (ATO, As2O3) in cancer chemotherapy has received extensive attention in recent years owing to its remarkable efficacy in treating acute promyelocytic leukemia (APL). To date, the use of ATO for clinical treatment of solid tumors is still limited by its poor biocompatibility and severe toxic side effects. To address these limitations, here we developed a pH-low insertion peptide (pHLIP) modified ATO-based multifunctional drug-delivery system (DDS), which is termed MnAs@SiO2-pHLIP. Read More

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http://xlink.rsc.org/?DOI=C9BM00216B
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http://dx.doi.org/10.1039/c9bm00216bDOI Listing
April 2019
9 Reads

HO-responsive nano-prodrug for podophyllotoxin delivery.

Biomater Sci 2019 Apr 8. Epub 2019 Apr 8.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.

The tumor microenvironment is different from that of normal tissue; therefore, the development of a prodrug that retains its efficacy in the tumor microenvironment can be useful in enhancing the anticancer properties of podophyllotoxin. An innovative podophyllotoxin prodrug (POD-PEG) was designed by linking podophyllotoxin to poly(ethylene glycol)(n) monomethacrylate with a H2O2-responsive oxalate ester bond. POD-PEG can self-assemble into stable nanoparticles (POD-PEG NPs). Read More

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http://dx.doi.org/10.1039/c9bm00344dDOI Listing

Augmented re-endothelialization and anti-inflammation of coronary drug-eluting stent by abluminal coating with magnesium hydroxide.

Biomater Sci 2019 Apr 8. Epub 2019 Apr 8.

Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea.

Drug-eluting stents (DESs) have been widely used as a treatment approach for coronary artery diseases. Generally, conventional DESs were fully covered with drugs and biodegradable polymers on both abluminal and luminal layers (i.e. Read More

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http://dx.doi.org/10.1039/c8bm01696hDOI Listing
April 2019
2 Reads

Photo-induced hydrogen-bonding complexes for drug periodic release.

Biomater Sci 2019 Apr 3. Epub 2019 Apr 3.

School of Materials and Chemical Engineering, Anhui Jianzhu University, Hefei, Anhui 230601, China.

The construction of intelligent supramolecular nanocarriers has received much attention for their potential application in chemotherapy. Herein, we report the successful design and synthesis of a photoreactive monomer, N'-(2-nitrobenzyl)-N-acryloyl glycinamide (NBNAGA). Using a poly(ethylene glycol) (PEG)-based macro-RAFT agent, the amphiphilic diblock copolymer (BCP), PEG-b-PNBNAGA, was prepared through a reversible addition-fragmentation chain-transfer (RAFT) polymerization. Read More

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http://dx.doi.org/10.1039/c9bm00269cDOI Listing
April 2019
3 Reads

Designing pH-triggered drug release iron oxide nanocomposites for MRI-guided photothermal-chemoembolization therapy of liver orthotopic cancer.

Biomater Sci 2019 Apr;7(5):1842-1851

Department of Interventional Radiology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.

Hepatic carcinoma (HCC) is a kind of aggressive malignancy with high levels of morbidity and mortality. Transcatheter intra-arterial (IA) injection has been recommended as an impactful local delivery method for HCC owing to the limited delivery efficiency of ordinary intravenous injection when used for clinical application. Herein, we developed a doxorubicin (DOX)-loaded and pH-responsive magnetic drug-loaded nanosystem containing single-crystal hematite (α-Fe2O3) nanocubes and pH-sensitive synthetic polydopamine (PDA) mixed with lipiodol for magnetic resonance imaging (MRI)-guided photothermal-chemoembolization treatment in an orthotopic liver cancer model. Read More

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http://dx.doi.org/10.1039/c9bm00056aDOI Listing

A cancellous bone matrix system with specific mineralisation degrees for mesenchymal stem cell differentiation and bone regeneration.

Biomater Sci 2019 Apr 3. Epub 2019 Apr 3.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, China. and Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, China.

Bone regenerative therapies have been explored using various biomaterial systems. Notably, collagen biomineralisation is believed to be essential for promoting bone regeneration. However, ideal bone repair materials with an appropriate mineralised matrix, superior osteogenic activity with early vascularisation, and recellularisation properties are still needed. Read More

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http://dx.doi.org/10.1039/c8bm01657gDOI Listing
April 2019
2 Reads

Succinylated casein-coated peptide-mesoporous silica nanoparticles as an antibiotic against intestinal bacterial infection.

Biomater Sci 2019 Apr 2. Epub 2019 Apr 2.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.

Increasing drug resistance necessitates the discovery of novel bactericides. Human defensin (HD) peptides can eliminate resistant bacteria and are promising candidates for next-generation antibiotics. T7E21R-HD5 is a potent bactericide designed by site mutations at enteric HD5. Read More

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http://dx.doi.org/10.1039/c9bm00003hDOI Listing
April 2019
1 Read

Cold atmospheric plasma (CAP)-modified and bioactive protein-loaded core-shell nanofibers for bone tissue engineering applications.

Biomater Sci 2019 Apr 1. Epub 2019 Apr 1.

Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA02115.

Coaxial electrospinning is a novel technique for producing core-shell nanofibers that provide a robust structure and deliver hydrophilic bioactive agents. Optimization of parameters used in the coaxial electrospinning process allows for the fabrication of uniform and bead-free polyvinyl alcohol (PVA)/poly (l-lactic acid) (PLLA) core-shell nanofibers. Herein, a cold atmospheric plasma (CAP) process was used to enhance the surface features of electrospun core-shell nanofibers for increased surface pore size and altered surface hydrophilicity. Read More

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http://dx.doi.org/10.1039/c8bm01284aDOI Listing
April 2019
1 Read

Outstanding Reviewers for Biomaterials Science in 2018.

Authors:

Biomater Sci 2019 Apr;7(5):1745

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http://dx.doi.org/10.1039/c9bm90021gDOI Listing

Site-dependent fluorescence enhanced polymers with a self-restricted GFP chromophore for living cell imaging.

Biomater Sci 2019 Mar 29. Epub 2019 Mar 29.

School of Chemistry and Chemical Engineering, Shanghai Key Lab of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China.

The β-barrel structure of green fluorescent protein (GFP) provides a confined environment to enhance its fluorescence efficiency. Inspired by the unique structure of GFP, we reported a self-restricted GFP chromophore analogue which was rationally grafted onto the middle or the terminal of poly(ethylene glycol)-block-poly(N-isopropyl acrylamide) (PEG-b-PNIPAM) via click chemistry to obtain PEG-GA-PNIPAM and PEG-PNIPAM-GA (GA: MeOBDPI). These structures were characterized through NMR, GPC, and FT-IR. Read More

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http://dx.doi.org/10.1039/c9bm00255cDOI Listing

Uptake of silica particulate drug carriers in an intestine-on-a-chip: towards a better in vitro model of nanoparticulate carrier and mucus interactions.

Biomater Sci 2019 Mar 28. Epub 2019 Mar 28.

Future Industries Institute and ARC Centre of Excellence Convergent Bio-Nano Science and Technology, University of South Australia, Mawson Lakes Campus, Adelaide, SA 5095, Australia.

Micro and nano-particulate carriers have potential to increase bioavailability of oral drugs, but must first overcome the mucus barrier of the intestinal epithelium to facilitate absorption and entry to systemic circulation. We report on mucus-silica nanoparticulate carrier interactions in an in vitro intestine-on-a-chip (IOAC) microfluidic model. Caco-2 cells cultured within the IOAC model recapitulate the morphology of the human intestinal epithelium that is currently lacking in traditional static Transwell models. Read More

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http://dx.doi.org/10.1039/c9bm00058eDOI Listing

Short, symmetric-helical peptides have narrow-spectrum activity with low resistance potential and high selectivity.

Biomater Sci 2019 Mar 28. Epub 2019 Mar 28.

Laboratory of Molecular Nutrition and Immunity, The Institute of Animal Nutrition, Northeast Agricultural University, Harbin, P. R. China.

Broad-spectrum antibiotics have, until now, been the mainstay of antibiotic therapy. However, the increasing threat of drug-resistant bacteria and the ecological imbalance of normal microbial communities have forced a reconsideration of the best strategies to treat such pathogens. Therefore, antibacterial agents with specific abilities of eliminating pathogens may provide long-term protection. Read More

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http://dx.doi.org/10.1039/c9bm00044eDOI Listing

Microfluidics for silica biomaterials synthesis: opportunities and challenges.

Biomater Sci 2019 Mar 28. Epub 2019 Mar 28.

Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, New Hampshire 03755, USA.

The rational design and controllable synthesis of silica nanomaterials bearing unique physicochemical properties is becoming increasingly important for a variety of biomedical applications from imaging to drug delivery. Microfluidics has recently emerged as a promising platform for nanomaterial synthesis, providing precise control over particle size, shape, porosity, and structure compared to conventional batch synthesis approaches. This review summarizes microfluidics approaches for the synthesis of silica materials as well as the design, fabrication and the emerging roles in the development of new classes of functional biomaterials. Read More

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http://xlink.rsc.org/?DOI=C9BM00238C
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http://dx.doi.org/10.1039/c9bm00238cDOI Listing
March 2019
6 Reads

Functional, UV-curable coating for the capture of circulating tumor cells.

Biomater Sci 2019 Mar 27. Epub 2019 Mar 27.

College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China.

The capture of circulating tumor cells (CTCs) plays a crucial role in the early diagnosis, personalized treatment and postoperative evaluation of malignant tumors. In this study, UV-curable coating technology was combined with antibody immobilization to enable CTC captures on poly(methyl methacrylate) (PMMA) substrates. Controlled amounts of carboxyl groups and polyethylene glycol (PEG) segments were introduced into the coating formulation to facilitate immobilization of antibodies and block non-specific protein adsorption, respectively. Read More

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http://dx.doi.org/10.1039/c9bm00264bDOI Listing
March 2019
1 Read

A dual deformable liposomal ointment functionalized with retinoic acid and epidermal growth factor for enhanced burn wound healing therapy.

Biomater Sci 2019 Mar 27. Epub 2019 Mar 27.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

An ointment containing retinoic acid deformable liposomes (TRA DLs) and epidermal growth factor cationic deformable liposomes (EGF CDLs) was prepared for the treatment of deep partial-thickness burns. The characterization tests confirmed both liposomes featured small particle sizes, high drug entrapment efficiencies and sustained drug release behavior. Compared with the free drug, TRA DLs and EGF CDLs exhibited superior skin permeation and remarkably increased drug deposition by 2. Read More

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http://dx.doi.org/10.1039/c8bm01569dDOI Listing

Polymer microchamber arrays for geometry-controlled drug release: a functional study in human cells of neuronal phenotype.

Biomater Sci 2019 Mar 27. Epub 2019 Mar 27.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Polyelectrolyte multilayer (PEM) microchambers can provide a versatile cargo delivery system enabling rapid, site-specific drug release on demand. However, experimental evidence for their potential benefits in live human cells is scarce. Equally, practical applications often require substance delivery that is geometrically constrained and highly localized. Read More

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http://dx.doi.org/10.1039/c8bm01499jDOI Listing
March 2019
2 Reads

Development of a microdevice-based human mesenchymal stem cell-mediated drug delivery system.

Biomater Sci 2019 Mar 27. Epub 2019 Mar 27.

Department of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, 2525 Pottsdamer Street, Tallahassee, Florida 32310-2870, USA.

Cell-mediated drug delivery systems utilize living cells as vehicles to achieve controlled delivery of drugs. One of the systems features integrating cells with disk-shaped microparticles termed microdevices into cell-microdevice complexes that possess some unique advantages over their counterparts. Human mesenchymal stem cells (hMSCs) have been extensively studied as therapeutic cells and used as carrier cells for drug-loaded nanoparticles or other functional nanoparticles. Read More

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http://xlink.rsc.org/?DOI=C8BM01634H
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http://dx.doi.org/10.1039/c8bm01634hDOI Listing
March 2019
2 Reads

An artificially engineered "tumor bio-magnet" for collecting blood-circulating nanoparticles and magnetic hyperthermia.

Biomater Sci 2019 Apr;7(5):1815-1824

Institute of Ultrasound Imaging of Chongqing Medical University, Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Yuzhong Distinct, Chongqing, 400010, P. R. China.

It is a great challenge to directly endow a tumor with specific functions for theranostic treatment. In this study, we report on a novel approach to transform a tumor into a "bio-magnet", to be magnetized on demand, in order to create an intrinsic tumor magnetic field that would collect magnetic nanoparticles (MNPs) circulating in the blood and achieve simultaneous magnetic hyperthermia. This was achieved by the localized intratumoral injection of liquid Nd2Fe14B/Fe3O4-PLGA, followed by solvent exchange that induces a liquid-to-solid transformation. Read More

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http://dx.doi.org/10.1039/c8bm01658eDOI Listing
April 2019
1 Read

Air-plasma treatment promotes bone-like nano-hydroxylapatite formation on protein films for enhanced in vivo osteogenesis.

Biomater Sci 2019 Mar 25. Epub 2019 Mar 25.

School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China and Department of Chemistry & Biochemistry Stephenson Life Sciences Research Center Institute for Biomedical Engineering, Science and Technology University of Oklahoma 101 Stephenson Parkway, Norman, Ok 73019-5300, USA.

Introducing hydroxylapatite (HAp) into biomolecular materials is a promising approach to improve their bone regenerative capability. Thus a facile method needs to be developed to achieve this goal. Here we show that a simple air-plasma treatment of silk fibroin (SF) films for 5 min induced the formation of bone-like plate-shaped nano-HAp (nHAp) on their surface and the resultant material efficiently enhanced in vivo osteogenesis. Read More

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http://xlink.rsc.org/?DOI=C9BM00020H
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http://dx.doi.org/10.1039/c9bm00020hDOI Listing
March 2019
10 Reads

Enhanced proliferation and differentiation of retinal progenitor cells through a self-healing injectable hydrogel.

Biomater Sci 2019 Mar 25. Epub 2019 Mar 25.

Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, P. R. China.

Retinal progenitor cell (RPC)-based transportation therapy is a promising strategy for repairing visual loss caused by retinal degeneration (RD) in people; however, its application is still significantly limited by the low effective delivery, proliferation and differentiation of RPCs. Herein, a self-healing injectable hydrogel (CS-Odex) based on chitosan hydrochloride (CS) and oxidized dextran (Odex) was developed via a dynamic Schiff-base linkage as a bioactive vehicle for the delivery of RPCs. Moreover, its biological effects on the RPC behaviors, including survival, proliferation and differentiation, were systematically evaluated. Read More

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http://xlink.rsc.org/?DOI=C8BM01579A
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http://dx.doi.org/10.1039/c8bm01579aDOI Listing
March 2019
5 Reads

Influence of the physicochemical characteristics of diatom frustules on hemorrhage control.

Biomater Sci 2019 Apr;7(5):1833-1841

Key Laboratory of Mariculture, Ocean University of China, Ministry of Education, Qingdao 266003, China.

Uncontrollable hemorrhage is the main cause of death in military and civilian accidents. It is therefore necessary and an urgent requirement to develop a safe and efficient hemostatic material. In this study, the hemostatic performance of frustules of three centric diatom species (Thalassiosira weissflogii, Thalassiosira sp. Read More

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http://dx.doi.org/10.1039/c9bm00099bDOI Listing
April 2019
1 Read

Current concepts in nanostructured contrast media development for in vivo photoacoustic imaging.

Biomater Sci 2019 Apr;7(5):1746-1775

Department of Industrial Chemistry "Toso Montanari", University of Bologna, Viale Risorgimento 4, 40136 Bologna, Italy.

Photoacoustic (PA) imaging is indeed one of the most promising bioimaging techniques for theranostics applications in humans, allowing for the visualization of blood vessels and melanomas with high spatial resolution. However, in order to overcome the endogenous contrast arising from interfering endogenous species such as haemoglobin and melanin, specific contrast agents need to be developed, allowing PAI to successfully identify targeted contrast in the range of wavelengths in which interference from the biomatrix is minimized. This has been first performed by small molecule dyes, which, however, suffer from some important limitations such as low hydrophilicity and short circulation times. Read More

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http://dx.doi.org/10.1039/c8bm01444bDOI Listing

A self-assembled DNA-nanoparticle with a targeting peptide for hypoxia-inducible gene therapy of ischemic stroke.

Biomater Sci 2019 Apr;7(5):2174-2190

Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Korea.

A self-assembled nanoparticle composed of hypoxia-specific anti-RAGE peptide (HSAP), heme oxygenase-1 plasmid (pHO1), and deoxycholate-conjugated polyethylenimine-2k (DP2k) was developed for ischemic stroke therapy. RAGE is over-expressed and induces inflammation in the ischemic brain. To inhibit RAGE-mediated signal transduction, HSAP was produced by recombinant DNA technology, based on the RAGE-binding domain of high mobility group box-1. Read More

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http://dx.doi.org/10.1039/c8bm01621fDOI Listing

A self-assembly and higher order structure forming triple helical protein as a novel biomaterial for cell proliferation.

Biomater Sci 2019 Apr;7(5):2191-2199

Division of Biochemistry and Biotechnology, Council of Scientific and Industrial Research-Central Leather Research Institute (CSIR-CLRI), Chennai, India.

Collagen plays a critical role in the structural design of the extracellular matrix (ECM) and cell signaling in mammals, which makes it one of the most promising biomaterials with versatile applications. However, there is considerable concern regarding the purity and predictability of the product performance. At present, it is mainly derived as a mixture of collagen (different types) from animal tissues, where the selective enrichment of a particular type of collagen is generally difficult and expensive. Read More

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http://dx.doi.org/10.1039/c9bm00186gDOI Listing
April 2019
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A chimeric, multivalent assembly of galectin-1 and galectin-3 with enhanced extracellular activity.

Biomater Sci 2019 Apr;7(5):1852-1862

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA 32611.

Galectins are attractive therapeutic candidates to control aberrant immune system activation because they can alter the phenotype and function of various innate and adaptive immune cells. However, use of exogenous galectin-1 ("G1") and galectin-3 ("G3") as immunomodulators is challenged by their high dosing requirements and dynamic quaternary structures. Here we report a chimeric assembly of G1 and G3 with enhanced extracellular activity ("G1/G3 Zipper"), which was created by recombinant fusion of G1 and G3 via a peptide linker that forms a two-stranded α-helical coiled-coil. Read More

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http://dx.doi.org/10.1039/c8bm01631cDOI Listing

Synthesis, characterization, and formulation of poly-puerarin as a biodegradable and biosafe drug delivery platform for anti-cancer therapy.

Biomater Sci 2019 Apr;7(5):2152-2164

Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510006, China.

Nano-drug delivery systems are widely used in medical diagnoses, tumour drug delivery and other fields due to their unique advantages. Thus, the preparation of more biocompatible nanocarriers by modifying natural materials has become a research hotspot in recent years. As a type of abundant and environment-friendly natural material, puerarin has been proven to be effective in the treatment of many diseases. Read More

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http://dx.doi.org/10.1039/c9bm00111eDOI Listing
April 2019
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Bioadhesive anisotropic nanogrooved microfibers directing three-dimensional neurite extension.

Biomater Sci 2019 Apr;7(5):2165-2173

Department of Engineering, Aarhus University, Aarhus 8000, Denmark.

Neurodegenerative diseases and acute nerve injuries are becoming global clinical problems. Engineering three-dimensional (3D), anisotropic neural cellular structures in vitro is therefore desirable in the regenerative medicine research community. Here, we present, for the first time, a single-step, facile but delicate, fabrication of a 3D macroporous microfibrous scaffold with both anisotropic nanogrooved topography and in situ functionalization with a mussel inspired bioadhesive, poly(norepinephrine) (pNE). Read More

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http://dx.doi.org/10.1039/c8bm01603hDOI Listing

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy.

Biomater Sci 2019 Apr;7(5):1825-1832

Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

As drug-delivery carriers for cancer chemotherapy, gatekeeper-capped mesoporous silica nanoparticles (MSNs) have been widely studied due to their high drug-loading capability, controlled drug release property and good biocompatibility. However, the currently reported gatekeeper-capped MSNs suffer from complex synthetic procedures, potential toxicity of gatekeepers, unsatisfactory control on drug stimuli-release, etc. In this work, we develop a simple but efficient approach to fabricate PEGylated organosilica-capped mesoporous silica nanoparticles (POMSNs) by employing a disulfide-doped organosilica coating as the gatekeeper formed by the hydrolysis and condensation of a silane coupling agent 3-(mercaptopropyl)trimethoxysilane (MPTMS) to block the mesopores of MSNs. Read More

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http://dx.doi.org/10.1039/c8bm01669kDOI Listing

Ferritin nanocage-based antigen delivery nanoplatforms: epitope engineering for peptide vaccine design.

Biomater Sci 2019 Apr;7(5):1794-1800

Department of pharmacology, Xiamen Medical College, Xiamen, 361008, China.

Biomedical applications and nanotechnological advances, including constrained synthesis, multimodal imaging, drug delivery, and bioassay, have strongly benefited from employing ferritin nanocages due to their remarkable properties of easy engineering, great biocompatible features, large capacity and so on. In this study, ferritin nanocages were used to display epitopes (model antigens derived from Enterovirus 71 (EV71) with different length) on C- and N-terminals and the loop zone to search for the optimal position for the fusion of the epitopes to the vaccine platform. The longest epitope displayed on the N-terminal and loop zone as well as the second longest peptide displayed on the loop zone of ferritin resulted in 100% passive protection of newborn BALB/c mice from the lethal EV71. Read More

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http://dx.doi.org/10.1039/c9bm00098dDOI Listing
April 2019
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Host defense peptide mimicking poly-β-peptides with fast, potent and broad spectrum antibacterial activities.

Biomater Sci 2019 Apr;7(5):2144-2151

State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.

Microbial infections have always been serious challenges to human health considering that antibiotics almost inevitably induce microbial resistance. Therefore, it is urgent to develop a new antibacterial agent that is active against drug-resistant bacteria and is less susceptible to microbial resistance. In this work, a series of host defense peptide (HDP) mimicking antibacterial poly-β-peptides were synthesized, characterized and evaluated for their biological activities. Read More

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http://dx.doi.org/10.1039/c9bm00248kDOI Listing

Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis.

Biomater Sci 2019 Apr;7(5):1863-1874

Johns Hopkins School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA.

Objective: Develop a drug-eluting stent construct with a reliable drug-release profile and adequate mechanically stability for a trial in a small animal model of laryngotracheal stenosis (LTS), a debilitating pathologic narrowing of the airway leading to significant shortness of breath.

Methods: Biodegradable, biocompatible stents containing 1.0% rapamycin made of PLLA-PCL (70% Poly-l-Lactide and 30% Polycaprolactone blend) and 50 : 50 PDLGA (Poly(dl-lactide-co-glycolide)) were compared. Read More

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http://dx.doi.org/10.1039/c8bm01623bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478537PMC
April 2019
5 Reads

Bifunctional magnetopolymersomes of iron oxide nanoparticles and carboxymethylcellulose conjugated with doxorubicin for hyperthermo-chemotherapy of brain cancer cells.

Biomater Sci 2019 Apr;7(5):2102-2122

Center of Nanoscience, Nanotechnology and Innovation - CeNano2I, Federal University of Minas Gerais - UFMG, Av. Antônio Carlos, 6627 - Belo Horizonte/MG, Brazil.

Glioblastoma is the most aggressive primary brain cancer, which has no cure yet. Emerging nanotheranostic alternatives such as magnetic iron oxide nanoparticles (MIONs) have great potential as multimodal cancer therapy mediators. They can act as nanocarriers of anticancer drugs and generate localized heat when exposed to an alternating magnetic field (AMF), resulting in combined effects of chemotherapy and magnetic hyperthermia therapy. Read More

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http://dx.doi.org/10.1039/c8bm01528gDOI Listing
April 2019
2 Reads

Biodistribution and toxicological evaluation of micron- and nano-sized erythrocyte-derived optical particles in healthy Swiss Webster mice.

Biomater Sci 2019 Apr;7(5):2123-2133

Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA.

Particle-based systems provide a capability for the delivery of imaging and/or therapeutic payloads. We have engineered constructs derived from erythrocytes, and doped with the FDA-approved near infrared dye, indocyanine green (ICG). We refer to these optical particles as NIR erythrocyte-mimicking transducers (NETs). Read More

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http://dx.doi.org/10.1039/c8bm01448eDOI Listing