16,089 results match your criteria Biomaterials[Journal]


Macroporous hydrogels derived from aqueous dynamic phase separation.

Biomaterials 2019 Feb 2;200:56-65. Epub 2019 Feb 2.

Tissue Engineering and Biofabrication Laboratory, Department of Health Sciences and Technology, ETH Zürich, Otto-Stern-Weg 7, 8093, Zürich, Switzerland. Electronic address:

A method to generate injectable macroporous hydrogels based on partitioning of polyethylene glycol (PEG) and high viscous polysaccharides is presented. Step growth polymerization of PEG was used to initiate a phase separation and the formation of a connected macroporous network with tunable dimensions. The possibilities and physical properties of this new category of materials were examined, and then applied to address some challenges in neural engineering. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.047DOI Listing
February 2019

Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy.

Biomaterials 2019 Feb 7;200:48-55. Epub 2019 Feb 7.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China; Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University, Shanghai, 200062, PR China. Electronic address:

Oxygen is known as an irreplaceable gas in the lives of most eukaryotic cells, yet researchers underestimate its importance, as in the case in many studies of tumors. The variable oxygen content of malignant solid tumors increases the difficulty of treatment. Thus, it could be reasonably inferred that the tumor oxygen microenvironment, if efficiently and completely regulated, could bring certain changes to existing therapies. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.02.007DOI Listing
February 2019

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis.

Biomaterials 2019 Feb 8;200:35-47. Epub 2019 Feb 8.

Faculty of Dentistry, National University of Singapore, Singapore; Tissue Engineering Program, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC exosomes in the regulation of inflammatory response, nociceptive behaviour, and condylar cartilage and subchondral bone healing in an immunocompetent rat model of temporomandibular joint osteoarthritis (TMJ-OA). We observed that exosome-mediated repair of osteoarthritic TMJs was characterized by early suppression of pain and degeneration with reduced inflammation, followed by sustained proliferation and gradual improvements in matrix expression and subchondral bone architecture, leading to overall joint restoration and regeneration. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.02.006DOI Listing
February 2019

Polymers with distinctive anticancer mechanism that kills MDR cancer cells and inhibits tumor metastasis.

Biomaterials 2019 Apr 25;199:76-87. Epub 2019 Jan 25.

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, 138669, Singapore. Electronic address:

Although mortality continues to decline over the past two decades, cancer is still a pervasive healthcare problem worldwide due to the increase in the number of cases, multidrug resistance (MDR) and metastasis. As a consequence of multidrug resistance, cancer treatment must rely on a host of chemotherapeutic agents and chemosensitizers to achieve remission. To overcome these problems, a series of biodegradable triblock copolymers of PEG, guanidinium-functionalized polycarbonate and polylactide (PEG-PGC-PDLA) is designed as chemotherapeutic agents. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.036DOI Listing

Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering.

Biomaterials 2019 Feb 7;200:25-34. Epub 2019 Feb 7.

Department of Biomedical Engineering, Yale University, New Haven, CT 06519, USA; Department of Anaesthesiology, Yale University, New Haven, CT 06519, USA. Electronic address:

Whole organ engineering paradigms typically involve repopulating acellular organ scaffolds with recipient-compatible cells, to generate a neo-organ that may provide key physiological functions. In the case of whole lung engineering, functionally endothelialized pulmonary vasculature is critical for establishing a fluid-tight barrier at the level of the alveolus, so that oxygen and carbon dioxide can be exchanged in the organ. We have previously developed a protocol to efficiently seed endothelial cells into the microvascular channels of decellularized lung scaffolds, but fully functional endothelial coverage, in terms of barrier function and resistance to thrombosis, was not achieved. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.02.005DOI Listing
February 2019

Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies.

Biomaterials 2019 Feb 5;200:15-24. Epub 2019 Feb 5.

Department of Mechanical Engineering, Stanford University, CA, USA. Electronic address:

Hydrogels are commonly used as artificial extracellular matrices for 3D cell culture and for tissue engineering. Viscoelastic hydrogels with tunable stress relaxation have recently been developed, and stress relaxation in the hydrogels has been found to play a key role in regulating cell behaviors such as differentiation, spreading, and proliferation. Here we report a simple but precise materials approach to tuning stress relaxation of alginate hydrogels with polyethylene glycol (PEG) covalently grafted onto the alginate. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.02.004DOI Listing
February 2019

Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapy.

Biomaterials 2019 Feb 6;200:1-14. Epub 2019 Feb 6.

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, People's Republic of China; College of Chemistry and Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, People's Republic of China. Electronic address:

Many efforts have focused on the cancer stem cell (CSC) targeting nano delivery system, however, the anticancer therapy efficacy is relative low due to the highly drug-resistance and drug efflux. Nucleus-targeted drug delivery is a promising strategy for reverse the drug resistance and drug efflux of CSCs, but in vivo nucleus-targeted drug delivery has been challenging. Herein, we designed a mesoporous silica nanoparticle (MSN)-based nucleus-targeted system, which could directly target the CSCs and further enter the nucleus by the surface modification of anti-CD133 and thermal-triggered exposure of TAT peptides under an alternating magnetic field (AMF). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.048DOI Listing
February 2019

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids.

Biomaterials 2019 Apr 22;199:63-75. Epub 2019 Jan 22.

Institute of Genetic Medicine, Newcastle University, UK. Electronic address:

Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation. To mimic this phenomenon in vitro, tissue decellularisation approaches have been developed, resulting in the generation of natural ECM scaffolds that have comparable physical and biochemical properties of the natural tissues and are currently gaining traction in tissue engineering and regenerative therapies due to the ease of standardised production, and constant availability. In this manuscript we report the successful generation of decellularised ECM-derived peptides from neural retina (decel NR) and retinal pigment epithelium (decel RPE), and their impact on differentiation of human pluripotent stem cells (hPSCs) to retinal organoids. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.028DOI Listing

Enhancing magnetic resonance/photoluminescence imaging-guided photodynamic therapy by multiple pathways.

Biomaterials 2019 Apr 2;199:52-62. Epub 2019 Feb 2.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Mitochondria, which are a major source of adenosine triphosphate (ATP) and apoptosis regulators, are the key organelles that promote tumor cell proliferation, and their dysfunction affects tumor cell behavior. Additionally, mitochondria have been shown to play a central role in the biosynthesis of protoporphyrin IX (PpIX), which is a widely used photosensitizer that has been used for tumor detection, monitoring and photodynamic therapy. Nevertheless, photosensitizers administrated exogenously are often restricted by limited bioavailability. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.044DOI Listing
April 2019
2 Reads

Biofabrication of a vascularized islet organ for type 1 diabetes.

Biomaterials 2019 Apr 24;199:40-51. Epub 2019 Jan 24.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Islet transplantation is superior to extrinsic insulin supplementation in the treating severe Type 1 diabetes. However, its efficiency and longevity are limited by substantial islet loss post-transplantation due to lack of engraftment and vascular supply. To overcome these limitations, we developed a novel approach to bio-fabricate functional, vascularized islet organs (VIOs) ex vivo. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.035DOI Listing
April 2019
1 Read

Macrophage cell tracking PET imaging using mesoporous silica nanoparticles via in vivo bioorthogonal F-18 labeling.

Biomaterials 2019 Apr 2;199:32-39. Epub 2019 Feb 2.

Department of Chemistry and Chemical Engineering, Inha University, 100 Inharo, Namgu, Incheon, 22212, South Korea. Electronic address:

We introduce an efficient cell tracking imaging protocol using positron emission tomography (PET). Since macrophages are known to home and accumulate in tumor tissues and atherosclerotic plaque, we design a PET imaging protocol for macrophage cell tracking using aza-dibenzocyclooctyne-tethered PEGylated mesoporous silica nanoparticles (DBCO-MSNs) with the short half-life F-18-labeled azide-radiotracer via an in vivo strain-promoted alkyne azide cycloaddition (SPAAC) covalent labeling reaction inside macrophage cells in vivo. This PET imaging protocol for in vivo cell tracking successfully visualizes the migration of macrophage cells into the tumor site by the bioorthogonal SPAAC reaction of DBCO-MSNs with [F]fluoropentaethylene glycolic azide ([F]2) to form F-labeled aza-dibenzocycloocta-triazolic MSNs (F-DBCOT-MSNs) inside RAW 264. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193006
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http://dx.doi.org/10.1016/j.biomaterials.2019.01.043DOI Listing
April 2019
1 Read

Near-infrared light remotely up-regulate autophagy with spatiotemporal precision via upconversion optogenetic nanosystem.

Biomaterials 2019 Apr 1;199:22-31. Epub 2019 Feb 1.

School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China. Electronic address:

In vivo noninvasively manipulating biological functions by the mediation of biosafe near infrared (NIR) light is becoming increasingly popular. For these applications, upconversion rare-earth nanomaterial holds great promise as a novel photonic element, and has been widely adopted in optogenetics. In this article, an upconversion optogenetic nanosystem that was promised to achieve autophagy up-regulation with spatiotemporal precision was designed. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.042DOI Listing
April 2019
8.557 Impact Factor

Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo.

Biomaterials 2019 Apr 2;199:10-21. Epub 2019 Feb 2.

Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710000, China; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710054, China; Instrument Analysis Center, Xi'an Jiaotong University, Xi'an 710054, China. Electronic address:

Targeted tumor imaging and efficient specific gene delivery in vivo has been one of the main challenges in gene-based cancer diagnosis and therapy. Herein, we engineered a citric acid-based polymer with intrinsical photoluminescence and gene loading capacity to achieve targeted delivery of siRNA and tumor imaging in vitro and in vivo. The multifunctional platform was formed from the self-assembling of poly (citric acid)-polymine conjugated with folic acid and rhodamine B (PPFR). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.045DOI Listing

A hybrid nanomaterial with NIR-induced heat and associated hydroxyl radical generation for synergistic tumor therapy.

Biomaterials 2019 Apr 31;199:1-9. Epub 2019 Jan 31.

Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, PR China; The Institute for Advanced Studies, Wuhan University, Wuhan, 430072, PR China. Electronic address:

Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatform based on carbon sphere dotted with cerium oxide and coated by cell membrane (MCSCe) was designed and synthesized with good biocompatibility, homologous targeting ability, and improved photophysical activity. Notably, MCSCe could realize accumulation of hydrogen peroxide (HO) in tumor cells and hyperthermia under single laser (808 nm) irradiation, which were simultaneously utilized by itself to produce more toxic hydroxyl radical (OH). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.041DOI Listing

Collagen scaffolds functionalised with copper-eluting bioactive glass reduce infection and enhance osteogenesis and angiogenesis both in vitro and in vivo.

Biomaterials 2019 Mar 23;197:405-416. Epub 2019 Jan 23.

Tissue Engineering Research Group (TERG), Dept. of Anatomy, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland; Trinity Centre for BioEngineering (TCBE), Trinity College Dublin (TCD), Dublin, Ireland; Advanced Materials and BioEngineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland. Electronic address:

The bone infection osteomyelitis (typically by Staphylococcus aureus) usually requires a multistep procedure of surgical debridement, long-term systemic high-dose antibiotics, and - for larger defects - bone grafting. This, combined with the alarming rise in antibiotic resistance, necessitates development of alternative approaches. Herein, we describe a one-step treatment for osteomyelitis that combines local, controlled release of non-antibiotic antibacterials with a regenerative collagen-based scaffold. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.031DOI Listing

Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease.

Biomaterials 2019 Mar 24;197:393-404. Epub 2019 Jan 24.

Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen, 518060, Guangdong, China. Electronic address:

Oxidative stress-induced mitochondrial dysfunction plays an important role in the pathogenesis of Alzheimer's disease (AD). Hydrogen molecule, a special antioxidant, can selectively scavenge highly cytotoxic reactive oxygen species such as ·OH, exhibiting a potential to treat AD by reducing oxidative stress. However, there is no effective route to realize the continuous and efficient accumulation of administrated hydrogen in AD brain owing to its low solubility. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.037DOI Listing
March 2019
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Apoptotic cell-mimicking gold nanocages loaded with LXR agonist for attenuating the progression of murine systemic lupus erythematosus.

Biomaterials 2019 Mar 23;197:380-392. Epub 2019 Jan 23.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Systemic lupus erythematosus (SLE) constitutes an autoimmune disease characterized by the breakdown of tolerance to self-antigens, sustained production of pathogenic autoantibodies, and damage to multiple organs and tissues. Nanoparticle (NP)-based therapeutics have demonstrated efficacy in attenuating the progression of SLE. However, investigations of nano-drugs that address the crucial initiating factor in the pathogenesis of SLE; e. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.034DOI Listing
March 2019
3 Reads
8.557 Impact Factor

Nanoparticle-mediated internal radioisotope therapy to locally increase the tumor vasculature permeability for synergistically improved cancer therapies.

Biomaterials 2019 Mar 21;197:368-379. Epub 2019 Jan 21.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address:

The limited tumor specific uptake of nanoparticles is one of major bottlenecks for clinical translation of nanoscale therapeutics. Herein, we propose a strategy using internal radioisotope therapy (RIT) delivered by liposomal nanoparticles to improve the tumor vasculature permeability, so as to increase the tumor specific uptake of the second-wave therapeutic nanoparticles for enhanced cancer therapies. Via a convenient method, a therapeutic radioisotope iodine-131 is labeled onto albumin-encapsulated liposomes with greatly improved radiolabeling stability compared to I labeled albumin. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.033DOI Listing
March 2019
2 Reads
8.557 Impact Factor

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications.

Biomaterials 2019 Mar 7;197:345-367. Epub 2019 Jan 7.

Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, MA, USA; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02139, MA, USA; Chemical and Biomolecular Engineering Department, University of California - Los Angeles, Los Angeles, CA 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.011DOI Listing

Modulation of cell-cell interactions for neural tissue engineering: Potential therapeutic applications of cell adhesion molecules in nerve regeneration.

Biomaterials 2019 Mar 21;197:327-344. Epub 2019 Jan 21.

School of Chemical & Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, 308232, Singapore. Electronic address:

Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in regenerating the injured nervous system, tissue engineering approaches are still insufficient to result in full functional recovery in severe nerve damages. Majority of these approaches only focus on growth factors and cell-extracellular matrix (ECM) interactions. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.030DOI Listing

Encapsulation of individual living cells with enzyme responsive polymer nanoshell.

Biomaterials 2019 Mar 21;197:317-326. Epub 2019 Jan 21.

Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. Electronic address:

Cell delivery in cell therapy is typically challenged by the low cell survival rate and immunological rejection during cells injection and circulation. Encapsulation of cells with semipermeable hydrogels or membranes can improve cell viability by resisting high shear force and inhibit immune response with the physical isolation effect. Herein, the individual HeLa cells and human mesenchymal stem cells (hMSCs) were encapsulated with enzyme responsive polymer nanoshell. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.029DOI Listing
March 2019
2 Reads

EGFL7 regulates sprouting angiogenesis and endothelial integrity in a human blood vessel model.

Biomaterials 2019 Mar 14;197:305-316. Epub 2019 Jan 14.

Center for International Research on Integrative Biomedical Systems (CIBiS), Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan; LIMMS/CNRS-IIS (UMI 2820), Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan; CNRS/IIS/COL/Lille University SMMiL-E Project, CNRS Délégation Nord-Pas de Calais et Picardie, 2 rue de Canonniers, Lille, Cedex 59046, France. Electronic address:

Elucidating the mechanisms underlying sprouting angiogenesis and permeability should enable the development of more effective therapies for various diseases, including retinopathy, cancer, and other vascular disorders. We focused on epidermal growth factor-like domain 7 (EGFL7) which plays an important role in NOTCH signaling and in the organization of angiogenic sprouts. We developed an EGFL7-knockdown in vitro microvessel model and investigated the effect of EGFL7 at a tissue level. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.022DOI Listing
March 2019
1 Read
8.557 Impact Factor

Engineered bone for probing organotypic growth and therapy response of prostate cancer tumoroids in vitro.

Biomaterials 2019 Mar 21;197:296-304. Epub 2019 Jan 21.

David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA. Electronic address:

Mechanistic analysis of metastatic prostate cancer (PCa) biology and therapy response critically depends upon clinically relevant three-dimensional (3D) bone-like, organotypic culture. We here combine an engineered bone-mimetic environment (BME) with longitudinal microscopy to test the growth and therapy response of 3D PCa tumoroids. Besides promoting both tumor-cell autonomous and microenvironment-dependent growth in PCa cell lines and patient-derived xenograft cells, the BME enables in vivo-like tumor cell response to therapy, and reveals bone stroma dependent resistance to chemotherapy and BME-targeted localization and induction of cytoxicity by Radium-223. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.027DOI Listing

Corrigendum to "The effect of enoxacin on osteoclastogenesis and reduction of titanium particle-induced osteolysis via suppression of JNK signaling pathway" [Biomaterials 35 (2014) 5721-5730].

Biomaterials 2019 Mar 22;197:294-295. Epub 2019 Jan 22.

Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.018DOI Listing
March 2019
1 Read

A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy.

Biomaterials 2019 Mar 18;197:284-293. Epub 2019 Jan 18.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; University of Science and Technology of China, Hefei, 230026, PR China; Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, PR China.

Despite multifunctional nanoparticles using for photothermal therapy can efficiently kill cancer cells, their further application is still hindered by the intrinsic high uptake in the reticuloendothelial system (RES) organs, causing the slow elimination from the body and potential toxicity to the body. Therefore, it is ideal to develop multifunctional nanoparticles which process the ability to effectively accumulate in tumors, while the nanoparticles can be rapidly excreted from the body via renal clearance after effective treatment. Herein, we report the multifunctional nanoparticles (FeTNPs) based on the coordination interaction of phenolic group and metal iron, which are composed of ferric iron, tannic acid (TA) and poly (glutamic acid)-graft-methoxypoly (ethylene glycol) (PLG-g-mPEG). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.025DOI Listing
March 2019
2 Reads

Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis.

Biomaterials 2019 Mar 18;197:268-283. Epub 2019 Jan 18.

State Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China. Electronic address:

A multifunctional CO/thermo/chemotherapy nanoplatform is here reported, which is composed of mesoporous carbon nanoparticles (MCN) as near infrared (NIR)-responsive drug carrier, doxorubicin (DOX) as chemotherapeutic drug and triiron dodecacarbonyl (FeCO) as thermosensitive CO prodrug. The nanoplatform could absorb near-infrared (NIR) light and convert it into ample heat to trigger CO release and could also release DOX in the acidic tumor microenvironment. More importantly, the generated CO molecules successfully increase cancer cell sensitivity to chemotherapeutics by the ferroptosis pathway. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.026DOI Listing
March 2019
2 Reads

HIF-prolyl hydroxylase 2 silencing using siRNA delivered by MRI-visible nanoparticles improves therapy efficacy of transplanted EPCs for ischemic stroke.

Biomaterials 2019 Mar 30;197:229-243. Epub 2018 May 30.

Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, China. Electronic address:

Endothelial progenitor cell (EPC)-based therapy has brought potential benefits to stroke patients as an important restorative therapeutics. However, its efficacy is limited by poor migration and survival ability. Here, we found out that hif-prolyl hydroxylase 2 (PHD2) silencing could enhance the migration and survival ability of EPCs which could improve the therapy efficacy for ischemic stroke. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183041
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http://dx.doi.org/10.1016/j.biomaterials.2018.05.053DOI Listing
March 2019
3 Reads

Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.

Biomaterials 2019 Mar 17;197:255-267. Epub 2019 Jan 17.

Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki, 210-0821, Japan; Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

There has been a progressive interest in the molecular design of polymers and lipids as synthetic carriers for targeting therapeutic mRNA in vivo with the ability to circumvent nuclease attack for treating intractable diseases. Herein, we developed a simple approach to attain one order of magnitude higher nuclease tolerability of mRNA through the formation of polyplex micelles (PMs) by combining ω-cholesteryl (ω-Chol)-poly (ethylene-glycol) (PEG)-polycation block copolymers with mRNA pre-hybridized with cholesterol (Chol)-tethered RNA oligonucleotides (Chol (+)-OligoRNA). Even one or a few short Chol (+)-OligoRNA anchors harboring along the 46-fold longer mRNA strand was sufficient to induce tight mRNA packaging in the PM core, as evidenced by Förster resonance energy transfer (FRET) measurement as well as by a longitudinal relaxation time (T) measurement using NMR. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.023DOI Listing
March 2019
2 Reads

A new class of biological materials: Cell membrane-derived hydrogel scaffolds.

Biomaterials 2019 Mar 11;197:244-254. Epub 2019 Jan 11.

Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA. Electronic address:

Biological materials are superior to synthetic biomaterials in biocompatibility and active interactions with cells. Here, a new class of biological materials, cell membrane-derived hydrogel scaffolds are reported for harnessing these advantages. To form macroporous scaffolds, vesicles derived from red blood cell membranes (RBCMs) are chemically crosslinked via cryogelation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193002
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http://dx.doi.org/10.1016/j.biomaterials.2019.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369705PMC
March 2019
13 Reads

Extracellular vesicles based self-grown gold nanopopcorn for combinatorial chemo-photothermal therapy.

Biomaterials 2019 Mar 14;197:220-228. Epub 2019 Jan 14.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China; National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, 430030, China; Hubei Engineering Research Center for Novel Drug Delivery System, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Here, we generated a popcorn-like gold nanostructure exploiting extracellular vesicles (EVs). EVs can first serve as the vehicle for chemotherapeutic drug doxorubicin (DOX). Taking advantages of EVs, gold nanoparticles can be then self-grown surrounding the EVs, assembling into popcorn-like nanostructure. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.024DOI Listing
March 2019
1 Read

Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect.

Biomaterials 2019 Mar 7;197:207-219. Epub 2019 Jan 7.

Centre for Translational Medicine Research & Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China; Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China. Electronic address:

Bone defect repair is a challenging clinical problem in musculoskeletal system, especially in orthopaedic disorders such as steroid associated osteonecrosis (SAON). Magnesium (Mg) as a biodegradable metal with properly mechanical properties has been investigating for a long history. In this study, Mg powder, poly (lactide-co-glycolide) (PLGA), β-tricalcium phosphate (β-TCP) were the elements to formulate a novel porous PLGA/TCP/Mg (PTM) scaffolds using low temperature rapid prototyping (LT-RP) technology. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.013DOI Listing
March 2019
2 Reads

Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers.

Biomaterials 2019 Mar 8;197:194-206. Epub 2019 Jan 8.

Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland; Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland. Electronic address:

Successful tissue engineering requires the generation of human scale implants that mimic the structure, composition and mechanical properties of native tissues. Here, we report a novel biofabrication strategy that enables the engineering of structurally organised tissues by guiding the growth of cellular spheroids within arrays of 3D printed polymeric microchambers. With the goal of engineering stratified articular cartilage, inkjet bioprinting was used to deposit defined numbers of mesenchymal stromal cells (MSCs) and chondrocytes into pre-printed microchambers. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2018.12.028DOI Listing
March 2019
3 Reads

Structural optimization and additional targets identification of antisense oligonucleotide G3139 encapsulated in a neutral cytidinyl-lipid combined with a cationic lipid in vitro and in vivo.

Biomaterials 2019 Mar 3;197:182-193. Epub 2019 Jan 3.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No.38 Xueyuan Road, Haidian District, Beijing 100191, China. Electronic address:

Antisense oligonucleotides (ASOs) usually contain a fully phosphorothioate (PS) backbone, which possibly interact with many genes and proteins under intracellular conditions. G3139 is an ASO that targets Bcl-2 mRNA and induces cell apoptosis. Here, we report a kind of cytidinyl-lipid combined with a cationic lipid (DNCA/CLD, molar ration, 28:3, named mix), which may interact with oligonucleotides via H-bond formation, pi-stacking and electrostatic interaction, accompanied by low zeta potentials. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2018.12.033DOI Listing
March 2019
3 Reads

3-D geometry and irregular connectivity dictate neuronal firing in frequency domain and synchronization.

Biomaterials 2019 Mar 11;197:171-181. Epub 2019 Jan 11.

Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA. Electronic address:

The replication of the complex structure and three dimensional (3-D) interconnectivity of neurons in the brain is a great challenge. A few 3-D neuronal patterning approaches have been developed to mimic the cell distribution in the brain but none have demonstrated the relationship between 3-D neuron patterning and network connectivity. Here, we used photolithographic crosslinking to fabricate in vitro 3-D neuronal structures with distinct sizes, shapes or interconnectivities, i. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.017DOI Listing
March 2019
1 Read

Corrigendum to "Black hollow silicon oxide nanoparticles as highly efficient photothermal agents in the second near-infrared window for in vivo cancer therapy" [Biomaterials 143 (2017) 120-129].

Biomaterials 2019 Mar 17;197:432-434. Epub 2019 Jan 17.

State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.021DOI Listing
March 2019
1 Read
8.557 Impact Factor

Creating a capture zone in microfluidic flow greatly enhances the throughput and efficiency of cancer detection.

Biomaterials 2019 Mar 8;197:161-170. Epub 2019 Jan 8.

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; Robert E. Fischell Institute for Biomedical Devices, University of Maryland, College Park, MD 20742, USA; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201, USA. Electronic address:

Efficient capture of rare circulating tumor cells (CTCs) from blood samples is valuable for early cancer detection to improve the management of cancer. In this work, we developed a highly efficient microfluidics-based method for detecting CTCs in human blood. This is achieved by creating separate capture and flow zones in the microfluidic device (ZonesChip) and using patterned dielectrophoretic force to direct cells from the flow zone into the capture zone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193002
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http://dx.doi.org/10.1016/j.biomaterials.2019.01.014DOI Listing
March 2019
6 Reads

Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion.

Biomaterials 2019 Mar 9;197:146-160. Epub 2019 Jan 9.

Departments of Anesthesiology, USA; Ophthalmology and Visual Science, College of Medicine, USA. Electronic address:

Retinal ischemia is a major cause of vision loss and impairment and a common underlying mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central retinal artery occlusion. The regenerative capacity of the diseased human retina is limited. Our previous studies have shown the neuroprotective effects of intravitreal injection of mesenchymal stem cells (MSC) and MSC-conditioned medium in retinal ischemia in rats. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.016DOI Listing
March 2019
1 Read
8.557 Impact Factor

Hierarchically targetable polysaccharide-coated solid lipid nanoparticles as an oral chemo/thermotherapy delivery system for local treatment of colon cancer.

Biomaterials 2019 Mar 9;197:86-100. Epub 2019 Jan 9.

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300, Taiwan. Electronic address:

Although oral formulations of anticancer chemotherapies are clinically available, the therapeutic action relies mostly on drug absorption, being inevitably accompanied with systemic side effects. It is thus desirable to develop oral therapy systems for the local treatment of colon cancers featured with highly selective delivery to cancer cells and minimized systemic drug absorption. The present study demonstrates the effective accumulation and cell uptake of the doxorubicin and superparamagnetic iron oxide nanoparticles-loaded solid lipid nanoparticle (SLN) delivery system for chemo/magnetothermal combination therapy at tumors by hierarchical targeting of folate (FA) and dextran coated on SLN surfaces in a sequential layer-by-layer manner. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193002
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http://dx.doi.org/10.1016/j.biomaterials.2019.01.019DOI Listing
March 2019
3 Reads

Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro.

Biomaterials 2019 Mar 2;197:72-85. Epub 2019 Jan 2.

Melbourne Urological Research Alliance (MURAL), Melbourne, Victoria, Australia.

The tumour microenvironment plays a vital role in the development of solid malignancies. Here we describe an in vitro human prostate cancer microtissue model that facilitates the incorporation and interrogation of key elements of the local prostatic tumour microenvironment. Primary patient-derived cancer-associated fibroblasts (CAFs) were cultured in three-dimensional (3D) melt electrowritten scaffolds where they deposited extensive extracellular matrix (ECM) and promoted significant changes in prostate epithelial morphology, when compared to matched non-malignant prostatic fibroblasts (NPFs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183086
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http://dx.doi.org/10.1016/j.biomaterials.2018.12.030DOI Listing
March 2019
7 Reads

Role of nuclear mechanosensitivity in determining cellular responses to forces and biomaterials.

Biomaterials 2019 Mar 8;197:60-71. Epub 2019 Jan 8.

Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea; Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea; Department of Nanobiomedical Science & BK21 PLUS Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea. Electronic address:

Tissue engineers use biomaterials or apply forces to alter cell behaviors and cure damaged/diseased tissues. The external physical cues perceived by cells are transduced intracellularly along the mechanosensitive machineries, including subcellular adhesion molecules and cytoskeletons. The signals are further channeled to a nucleus through the physical links of nucleoskeleton and cytoskeleton or the biochemical translocation of transcription factors. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.010DOI Listing
March 2019
1 Read
8.557 Impact Factor

Oxygenated theranostic nanoplatforms with intracellular agglomeration behavior for improving the treatment efficacy of hypoxic tumors.

Biomaterials 2019 Mar 4;197:129-145. Epub 2019 Jan 4.

School of Life Science, Chongqing University, Chongqing 400044, PR China. Electronic address:

Hypoxia plays vital roles in the development of tumor resistance against typical anticancer therapies and local reoxygenation has proved effective to overcome the hypoxia-induced chemoresistance. Perfluorocarbon (PFC) is an FDA approved oxygen carrier and currently vigorously investigated for oxygen delivery to tumors. This study reports a perfluorocarbon and etoposide (EP) loaded porous hollow FeO-based theranostic nanoplatform capable of delivering oxygen to solid tumors to enhance their susceptibility against EP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193000
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http://dx.doi.org/10.1016/j.biomaterials.2019.01.002DOI Listing
March 2019
5 Reads

Injectable mineralized microsphere-loaded composite hydrogels for bone repair in a sheep bone defect model.

Biomaterials 2019 Mar 10;197:119-128. Epub 2019 Jan 10.

Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA; Department of Orthopaedic Surgery, School of Medicine, UC Davis Health, Sacramento, CA 95817, USA. Electronic address:

The efficacy of cell-based therapies as an alternative to autologous bone grafts requires biomaterials to localize cells at the defect and drive osteogenic differentiation. Hydrogels are ideal cell delivery vehicles that can provide instructional cues via their composition or mechanical properties but commonly lack osteoconductive components that nucleate mineral. To address this challenge, we entrapped mesenchymal stromal cells (MSCs) in a composite hydrogel based on two naturally-derived polymers (alginate and hyaluronate) containing biomineralized polymeric microspheres. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193000
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http://dx.doi.org/10.1016/j.biomaterials.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363840PMC
March 2019
8 Reads

Probing cellular response to topography in three dimensions.

Biomaterials 2019 Mar 8;197:101-118. Epub 2019 Jan 8.

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA. Electronic address:

Biophysical aspects of in vivo tissue microenvironments include microscale mechanical properties, fibrillar alignment, and architecture or topography of the extracellular matrix (ECM). These aspects act in concert with chemical signals from a myriad of diverse ECM proteins to provide cues that drive cellular responses. Here, we used a bottom-up approach to build fibrillar architecture into 3D amorphous hydrogels using magnetic-field driven assembly of paramagnetic colloidal particles functionalized with three types of human ECM proteins found in vivo. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.009DOI Listing
March 2019
2 Reads

Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca delivery.

Biomaterials 2019 Mar 4;197:51-59. Epub 2019 Jan 4.

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291, Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea. Electronic address:

Mitochondria are the primary organelle of regulating apoptosis, and intracellular calcium ions are a key component of pro-apoptosis induction. Herein, we report an artificial apoptosis-inducing polypeptide that destabilizes the mitochondrial membrane and transports calcium ions into the cytosol, thereby synergistically creating severe oxidative conditions. The oxidative stress highly activates an apoptotic signaling cascade, and also inhibits cell migration and invasion in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.006DOI Listing
March 2019
2 Reads

Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo.

Biomaterials 2019 Mar 4;197:41-50. Epub 2019 Jan 4.

CAS Key Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, and Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China. Electronic address:

Zeolitic imidazole frameworks (ZIFs) are becoming a notable nanosystem in biomedicine field, due to their unique properties of favorable biocompatibility, pH-responsive degradable structure and high drug loading. Compared with the increasing attention on ZIF-8 in cancer diagnosis and treatment, there is limited research about the bio-application of ZIF-90, especially its in vivo therapeutic efficacy and related toxicity. Here, we synthesize nano ZIF-90 through a fast self-assembling process, and the synthesized nano ZIF-90 is about 75 nm with a negative zeta potential, providing better mitochondria targetability, cell biocompatibility and in vivo survival rate comparing to nano ZIF-8. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.001DOI Listing
March 2019
4 Reads

In situ vaccination with biocompatibility controllable immuno-sensitizer inducing antitumor immunity.

Authors:
Heejun Shin Kun Na

Biomaterials 2019 Mar 7;197:32-40. Epub 2019 Jan 7.

Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea, 43 Jibongro, Wonmi-gu, Bucheon-si, Gyeonggi do, 14662, Republic of Korea. Electronic address:

Anticancer immunotherapy is emerging as a promising tumor treatment that can replace the conventional tumor treatment such as surgery, radiation and chemo drug, but its therapeutic effect against solid tumor is limited due to the tumor microenvironment (TME). Herein, to overcome this limitation, the biocompatibility controllable immuno-sensitizer (BCI) based on polyethylene imine that can be applied to solid tumors is developed. BCI accumulates in the tumors by EPR effect and induces in situ tumor destruction that convert tumors into antigen source by biocompatibility change through surface charge switching in response to the acidic TME. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.015DOI Listing
March 2019
2 Reads

Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation.

Biomaterials 2019 Mar 7;197:20-31. Epub 2019 Jan 7.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

Complete transected spinal cord injury (SCI) severely influences the quality of life and mortality rates of animals and patients. In the past decade, many simple and combinatorial therapeutic treatments have been tested in improving locomotor function in animals with this extraordinarily challenging SCI. The potential mechanism for promotion of locomotor function relies either on direct motor axon regeneration through the lesion gap or indirect neuronal relay bridging to functionally reconnect transected spinal stumps. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.012DOI Listing
March 2019
1 Read
8.557 Impact Factor

Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease.

Biomaterials 2019 Mar 24;197:417-431. Epub 2018 Dec 24.

Department of Chemistry, Jinan University, Guangzhou 510632, China. Electronic address:

Alzheimer's disease (AD) is a neurodegenerative disease with a complex pathogenesis. Controlled release, target ability, and multi-channel synergistic treatment are key factors associated with the success of AD drugs. Herein, we report a novel mesoporous nano-selenium (MSe) release delivery system (MSe-Res/Fc-β-CD/Bor) based on the borneol (Bor) target, β-cyclodextrin nanovalves (Fc-β-CD) with loaded resveratrol (Res). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2018.12.027DOI Listing
March 2019
2 Reads

Meningeal inflammatory response and fibrous tissue remodeling around intracortical implants: An in vivo two-photon imaging study.

Biomaterials 2019 Mar 31;195:111-123. Epub 2018 Dec 31.

Bioengineering, University of Pittsburgh, United States; Center for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, United States. Electronic address:

Meningeal inflammation and encapsulation of neural electrode arrays is a leading cause of device failure, yet little is known about how it develops over time or what triggers it. This work characterizes the dynamic changes of meningeal inflammatory cells and collagen-I in order to understand the meningeal tissue response to neural electrode implantation. We use in vivo two-photon microscopy of CX3CR1-GFP mice over the first month after electrode implantation to quantify changes in inflammatory cell behavior as well as meningeal collagen-I remodeling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612183086
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http://dx.doi.org/10.1016/j.biomaterials.2018.12.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350934PMC
March 2019
4 Reads