16,854 results match your criteria Biomaterials[Journal]


On-demand drug release nanoplatform based on fluorinated aza-BODIPY for imaging-guided chemo-phototherapy.

Biomaterials 2020 Jul 1;256:120211. Epub 2020 Jul 1.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing, 211800, China; School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing, 210044, China. Electronic address:

Intelligent drug delivery systems (DDS), integrating with multi-modal imaging guidance and controlled drug release, have practical significance in enhancing the therapeutic efficiency of tumors. Herein, fluorinated aza-boron-dipyrromethene (NBF) with high near-infrared absorption is synthesized by introducing nonadecafluorodecanoic acid into aza-BODIPY via the amide bond. Through the co-precipitation methods, nanoparticles (NPs) based on NBF are fabricated and the obtained NBF NPs can not only load with DOX with a high loading efficiency (25%, DNBF NPs), but also absorb PFC droplets (1H-perfluoropentane) with bp of 42 °C because of the fluorinated chains inside NBF NPs (PDNBF NPs). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120211DOI Listing

Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip.

Biomaterials 2020 Jun 26;256:120195. Epub 2020 Jun 26.

School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, 85287, USA; Biodesign Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA. Electronic address:

Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the leading cause of mortality worldwide. Considerable research into human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has highlighted their immense potential in the development of in vitro human cardiac tissues for broad mechanistic, therapeutic, and patient-specific disease modeling studies in the pursuit of CVD research. However, the relatively immature state of hPSC-CMs remains an obstacle in enhancing clinical relevance ofengineered cardiac tissue models. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120195DOI Listing

Gut-on-a-chip: Current progress and future opportunities.

Biomaterials 2020 Jun 14;255:120196. Epub 2020 Jun 14.

Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA, USA; Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA; Department of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California, Los Angeles, CA, USA; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA. Electronic address:

Organ-on-a-chip technology tries to mimic the complexity of native tissues in vitro. Important progress has recently been made in using this technology to study the gut with and without microbiota. These in vitro models can serve as an alternative to animal models for studying physiology, pathology, and pharmacology. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120196DOI Listing

Direct 3D bioprinting of cardiac micro-tissues mimicking native myocardium.

Biomaterials 2020 Jun 22;256:120204. Epub 2020 Jun 22.

Materials Science and Engineering Program, University of California San Diego, USA; Department of NanoEngineering, University of California San Diego, USA; Department of Bioengineering, University of California San Diego, USA. Electronic address:

The heart possesses a complex three-dimensional (3D) laminar myofiber organization; however, because engineering physiologically relevant 3D tissues remains a technical challenge, the effects of cardiomyocyte alignment on excitation-contraction coupling, shortening and force development have not been systematically studied. Cellular shape and orientations in 3D can be controlled by engineering scaffold microstructures and encapsulating cells near these geometric cues. Here, we show that a novel method of cell encapsulation in 3D methacrylated gelatin (GelMA) scaffolds patterned via Microscale Continuous Optical Printing (μCOP) can rapidly micropattern neonatal mouse ventricular cardiomyocytes (NMVCMs) in photocrosslinkable hydrogels. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120204DOI Listing

Spatiotemporally tracking of nano-biofilaments inside the nuclear pore complex core.

Biomaterials 2020 Jun 23;256:120198. Epub 2020 Jun 23.

Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, 920-1192, Japan; WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, 920-1192, Japan. Electronic address:

Nuclear pore complex (NPC) is a gating nanomachine with a central selective barrier composed mainly of Nups, which contain intrinsically disordered (non-structured) regions (IDRs) with phenylalanine-glycine (FG) motifs (FG-NUPs). The NPC central FG network dynamics is poorly understood, as FG-NUPs liquid-liquid phase separation (LLPS) have evaded structural characterization. Moreover, the working mechanism of single FG-NUP-biofilaments residing at the central lumen is unknown. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120198DOI Listing

Toward understanding the prolonged circulation and elimination mechanism of crosslinked polymeric micelles in zebrafish model.

Biomaterials 2020 Jun 25;256:120180. Epub 2020 Jun 25.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. Electronic address:

Understanding the behaviors of nanomedicines in vivo is one of the most important prerequisites for the design and optimization of nanomedicines. However, the in vivo tracking of nanomedicines in rodents is severely limited by the restricted imaging possibilities within these animals. To meet these needs, the FRET (fluorescence or Förster resonance energy transfer) imaging combined with visual zebrafish larvae model (7 dpf) was used to study the behaviors of polymeric micelles in vivo at high spatiotemporal resolution. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120180DOI Listing

Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow.

Biomaterials 2020 Jun 23;256:120183. Epub 2020 Jun 23.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada; Faculty of Dentistry, University of Toronto, Toronto, Canada. Electronic address:

Recently reported biomaterial-based approaches toward prevascularizing tissue constructs rely on biologically or structurally complex scaffolds that are complicated to manufacture and sterilize, and challenging to customize for clinical applications. In the current work, a prevascularization method for soft tissue engineering that uses a non-patterned and non-biological scaffold is proposed. Human fibroblasts and HUVECs were seeded on an ionomeric polyurethane-based hydrogel and cultured for 14 days under medium perfusion. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120183DOI Listing

Localized mandibular infection affects remote in vivo bioreactor bone generation.

Biomaterials 2020 Jun 23;256:120185. Epub 2020 Jun 23.

Department of Bioengineering, Rice University, Houston, TX, USA. Electronic address:

Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six sheep were inoculated with 10 colony forming units of Staphylococcus aureus; three sheep were implanted with unloaded porous space maintainers and three sheep were implanted with vancomycin-loaded space maintainers within the defect site. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120185DOI Listing

Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics.

Biomaterials 2020 Jun 17;256:120206. Epub 2020 Jun 17.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China. Electronic address:

Silicene as an emerging two-dimensional material (2DM) spurs the broad research interests due to its prominent electronic and physical properties, however, still lacking in exploitation for the biological and medical practices. Herein, we constructed a 2D silicene-based theranostic nanoplatform, MnO@silicene-BSA (MS-BSA), with tumor microenvironment (TME)-responsive and synergistic hyperthermia-augmented catalytic activity when irradiated by near infrared-II (NIR-II) laser because of the high photothermal-conversion efficiency of 2D silicene matrix. Such MS-BSA nanosheets possess the capability to react with glutathione (GSH) to generate Mn and glutathione disulfide (GSSG) under acidity/reducing TME condition. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120206DOI Listing

In vitro platform establishes antigen-specific CD8 T cell cytotoxicity to encapsulated cells via indirect antigen recognition.

Biomaterials 2020 Jun 15;256:120182. Epub 2020 Jun 15.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA; Graduate Program in Biomedical Sciences, College of Medicine, University of Florida, Gainesville, FL, USA; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA. Electronic address:

The curative potential of non-autologous cellular therapy is hindered by the requirement of anti-rejection therapy. Cellular encapsulation within nondegradable biomaterials has the potential to inhibit immune rejection, but the efficacy of this approach in robust preclinical and clinical models remains poor. While the responses of innate immune cells to the encapsulating material have been characterized, little attention has been paid to the contributions of adaptive immunity in encapsulated graft destabilization. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120182DOI Listing

Controllable synthesis of versatile mesoporous organosilica nanoparticles as precision cancer theranostics.

Biomaterials 2020 Jun 20;256:120191. Epub 2020 Jun 20.

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address:

Despite the advantages of mesoporous silica nanoparticles (MSNs) in drug delivery, the inherent non-biodegradability seriously impedes the clinical translation of inorganic MSNs, so the current research focus has been turned to mesoporous organosilica nanoparticles (MONs) with higher biocompatibility and easier biodegradability. Recent remarkable advances in silica fabrication chemistry have catalyzed the emergence of a library of MONs with various structures and functions. This review will summarize the latest state-of-the-art studies on the precise control of morphology, structure, framework, particle size and pore size of MONs, which enables the precise synthesis of MONs with suitable engineering for precision stimuli-responsive drug delivery/release, bioimaging and synergistic therapy. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120191DOI Listing

Superhydrophilic fluorinated polymer and nanogel for high-performance F magnetic resonance imaging.

Biomaterials 2020 Jun 17;256:120184. Epub 2020 Jun 17.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, PR China. Electronic address:

F magnetic resonance imaging (F MRI), a kind of non-invasive and non-radioactive diagnostic technique with no endogenous background signals, opens up new research avenues for accurate molecular imaging studies. However, F MRI is manily limited by the performance of contrast agents. Here, for the first time, we presented the zwitterionic fluorinated polymer and nanogel as new types of superhydrophilic, sensitive and ultra-stable F MRI contrast agents. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120184DOI Listing

Sweat gland regeneration: Current strategies and future opportunities.

Biomaterials 2020 Jun 18;255:120201. Epub 2020 Jun 18.

Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department and 4th Medical Center, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing, 100048, PR China. Electronic address:

For patients with extensive skin defects, loss of sweat glands (SwGs) greatly decreases their quality of life. Indeed, difficulties in thermoregulation, ion reabsorption, and maintaining fluid balance might render them susceptible to hyperthermia, heatstroke, or even death. Despite extensive studies on the stem cell biology of the skin in recent years, in-situ regeneration of SwGs with both structural and functional fidelity is still challenging because of the limited regenerative capacity and cell fate control of resident progenitors. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120201DOI Listing

Cascade of reactive oxygen species generation by polyprodrug for combinational photodynamic therapy.

Biomaterials 2020 Jun 18;255:120210. Epub 2020 Jun 18.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China. Electronic address:

The redox status of cancer cells is well regulated by the balance between the reactive oxygen species (ROS) generation and elimination. Thus, the overall elevation of ROS level above the cellular tolerability threshold would lead to apoptotic or necrotic cell death. Herein, cinnamaldehyde (CA), a kind of oxidative stress amplified agent, was combined with photosensitizer pheophorbide A (PA) to promote the generation of ROS though synergistically endogenous and exogenous pathways. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120210DOI Listing

Metabolic modulation via mTOR pathway and anti-angiogenesis remodels tumor microenvironment using PD-L1-targeting codelivery.

Biomaterials 2020 Jun 12;255:120187. Epub 2020 Jun 12.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China; NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, China; Zhongshan Branch, the Institute of Drug Research and Development, Chinese Academy of Sciences, Zhongshan, China. Electronic address:

Tumor microenvironment (TME) closely affects cancer progression by promoting cancer cell survival and proliferation, drug resistance, metastasis, and immunosuppression as well. Remodeling TME is a promising therapeutic strategy for anticancer. mTOR signaling is an essential regulator for cellular metabolism and tumor-associated macrophages (TAMs) repolarization. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120187DOI Listing

Albumin-constrained large-scale synthesis of renal clearable ferrous sulfide quantum dots for T-Weighted MR imaging and phototheranostics of tumors.

Biomaterials 2020 Jun 16;255:120186. Epub 2020 Jun 16.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Shanghai, 200072, China. Electronic address:

Ultrasmall-sized iron-based nanoparticles are showing increasing potentials to be alternatives as T-weighted magnetic resonance imaging (MRI) contrast agents to the currently-used gadolinium-based compounds. However, their synthesis particularly in a large-scale and green fashion is still a big challenge. Herein, we report an albumin-constrained strategy to synthesize tiny and highly dispersible ferrous sulfide (termed FeS@BSA) quantum dots (QDs) at ambient conditions. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120186DOI Listing

Construction and application of therapeutic metal-polyphenol capsule for peripheral artery disease.

Biomaterials 2020 Jun 15;255:120199. Epub 2020 Jun 15.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, PR China. Electronic address:

Lesions of patients with peripheral artery disease (PAD) are in a harmful microenvironment, which features increased oxidative stress and inflammatory infiltration. Hence, it is essential to improve the microenvironment along with angiogenesis. In this study, metal-polyphenol capsules (Cu-EGCG), which combines the therapeutic anti-inflammatory and antioxidant activities of EGCG and the angiogenic activity of copper ions, were synthesized through coordination between EGCG and copper ions. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120199DOI Listing
June 2020
8.557 Impact Factor

Targeted nanoparticles towards increased L cell stimulation as a strategy to improve oral peptide delivery in incretin-based diabetes treatment.

Biomaterials 2020 Jun 17;255:120209. Epub 2020 Jun 17.

Université Catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, 1200 Brussels, Belgium. Electronic address:

The delivery of therapeutic peptides via the oral route remains one of biggest challenges in the pharmaceutical industry. Recently, we have described an alternative improved drug delivery system for peptide delivery via the oral route, consisting of a lipidic nanocapsule. Despite the striking effects observed, it is still essential to develop strategies to strengthen the nanocarriers' glucagon-like peptide-1 (GLP-1) secretory effect of the nanocarrier and/or prolong its antidiabetic effect in vivo to facilitate its translation into the clinic. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120209DOI Listing
June 2020
8.557 Impact Factor

Bioorthogonal click chemistries enable simultaneous spatial patterning of multiple proteins to probe synergistic protein effects on fibroblast function.

Biomaterials 2020 Jun 16;255:120205. Epub 2020 Jun 16.

Department of Chemical and Biological Engineering, University of Colorado at Boulder, Boulder, CO, 80303, USA; BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO, 80303, USA. Electronic address:

Three biorthogonal click reactions, a photoinitiated thiol-yne reaction, an azide-alkyne cycloaddition, and a methyltetrazine-transcyclooctene Diels Alder, were used to independently control the presentation of several bioactive proteins to valvular interstitial cells (VICs) in hydrogel scaffolds. Tethered fibroblast growth factor (FGF-2) was found to suppress myofibroblast activation (from 48 ± 7% to 17 ± 6%) and promote proliferation (from 10 ± 2% to 54 ± 3%) at a concentration of 10 ng/mL. In the presence of the pro-fibrotic cytokine transforming growth factor-beta (TGF-β1), FGF-2 could protect the VIC fibroblast phenotype, even at much higher concentrations of TGF-β1 than that of FGF-2. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120205DOI Listing

Angiogenic biomaterials to promote therapeutic regeneration and investigate disease progression.

Biomaterials 2020 Jun 14;255:120207. Epub 2020 Jun 14.

Dept. Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address:

The vasculature is a key component of the tissue microenvironment. Traditionally known for its role in providing nutrients and oxygen to surrounding cells, the vasculature is now also acknowledged to provide signaling cues that influence biological outcomes in regeneration and disease. These cues come from the cells that comprise vasculature, as well as the dynamic biophysical and biochemical properties of the surrounding extracellular matrix that accompany vascular development and remodeling. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120207DOI Listing

Chlorin e6 and CRISPR-Cas9 dual-loading system with deep penetration for a synergistic tumoral photodynamic-immunotherapy.

Biomaterials 2020 Jun 14;255:120194. Epub 2020 Jun 14.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, 610041, PR China. Electronic address:

Photodynamic therapy (PDT) is a relatively safe and clinically promising treatment to combat primary tumors, especially epidermal carcinoma, while has negligible effects on distant metastasis. Therefore, this work reports a multifunctional nanosystem (HPR@CCP) exerting a combined photodynamic and immunotherapy to amplify the therapeutic effect on primary tumors and distant metastasis. Specifically, this nanosystem was obtained by electrostatic adsorption of a negatively charged hyaluronic acid "shell" with a positively charged "core" consisting of the CRISPR-Cas9 system targeting the Ptpn2 gene (Cas9-Ptpn2) and a modified mitochondria-targeting chlorin e6 (TPP-PEI-Ce6). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120194DOI Listing

Harnessing carbon monoxide-releasing platforms for cancer therapy.

Biomaterials 2020 Jun 15;255:120193. Epub 2020 Jun 15.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, PR China. Electronic address:

Carbon monoxide (CO) is a gaseous molecule that has drawn growing concerns for cancer treatment, due to its multifaceted regulation of cellular function and the tumor microenvironment. The past decades have witnessed extensive efforts into this emerging field, centered in the development of intelligent CO donors and CO delivery based on nanomaterials. However, CO delivery is beset with biosafety problems arising from burst release and the demand for high therapeutic concentrations in tumor tissues. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120193DOI Listing

Towards systems tissue engineering: Elucidating the dynamics, spatial coordination, and individual cells driving emergent behaviors.

Biomaterials 2020 Jun 14;255:120189. Epub 2020 Jun 14.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Biomaterial systems have enabled the in vitro production of complex, emergent tissue behaviors that were not possible with conventional two-dimensional culture systems, allowing for analysis of both normal development and disease processes. We propose that the path towards developing the design parameters for biomaterial systems lies with identifying the molecular drivers of emergent behavior through leveraging technological advances in systems biology, including single cell omics, genetic engineering, and high content imaging. This growing research opportunity at the intersection of the fields of tissue engineering and systems biology - systems tissue engineering - can uniquely interrogate the mechanisms by which complex tissue behaviors emerge with the potential to capture the contribution of i) dynamic regulation of tissue development and dysregulation, ii) single cell heterogeneity and the function of rare cell types, and iii) the spatial distribution and structure of individual cells and cell types within a tissue. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120189DOI Listing

Lysine demethylase KDM3A regulates nanophotonic hyperthermia resistance generated by 2D silicene in breast cancer.

Biomaterials 2020 Jun 10;255:120181. Epub 2020 Jun 10.

Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address:

Breast cancer (BC) is the most common malignant disease affecting women's health worldwide. The benefits from conventional therapeutic modalities are severely limited. An increasing number of promising photothermal materials have been recently developed and introduced into the therapeutic regimens of BC, but the underlying biological mechanism remains unclear. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120181DOI Listing

Conformable polyimide-based μECoGs: Bringing the electrodes closer to the signal source.

Biomaterials 2020 Jun 15;255:120178. Epub 2020 Jun 15.

Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany; BrainLinks-BrainTools Center, University of Freiburg, Germany; Bernstein Center Freiburg, University of Freiburg, Germany.

Structural biocompatibility is a fundamental requirement for chronically stable bioelectronic devices. Newest neurotechnologies are increasingly focused on minimizing the foreign body response through the development of devices that match the mechanical properties of the implanted tissue and mimic its surface composition, often compromising on their robustness. In this study, an analytical approach is proposed to determine the threshold of conformability for polyimide-based electrocorticography devices. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120178DOI Listing

Lymph node-targeted immune-activation mediated by imiquimod-loaded mesoporous polydopamine based-nanocarriers.

Biomaterials 2020 Jun 16;255:120208. Epub 2020 Jun 16.

Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing, 400044, China. Electronic address:

Toll-like receptor (TLR) agonists are the potent stimulants of innate immune system and hold promises as an adjuvant for anticancer immunotherapy. Unfortunately, most of them are limited by a prompt dissemination, and thus caused "wasted inflammation". Hence, how to restrict their action radius into lymphoid tissues is of great relevance to enhance their efficacy and concomitantly alleviates the side effects. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120208DOI Listing

Emerging nanotherapeutics for antithrombotic treatment.

Biomaterials 2020 Jun 12;255:120200. Epub 2020 Jun 12.

Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address:

Thrombus causes insufficient blood flow and ischemia damages to brain and heart, leading to life-threatening cardio-cerebrovascular diseases. Development of efficient antithrombotic strategies has long been a high priority, owing to the high morbidity and mortality of thrombotic diseases. With the rapid development of biomedical nanotechnology in diagnosis and treatment of thrombotic disorder, remarkable progresses have been made in antithrombotic nanomedicines in recent years. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120200DOI Listing

Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation.

Biomaterials 2020 Jun 13;255:120197. Epub 2020 Jun 13.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, Jiangsu, 215006, PR China; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215007, PR China. Electronic address:

Bone endoprosthesis in patients with systemic chronic inflammation frequently leads to poor osseointegration after implantation mainly due to the increase in pro-inflammatory cytokines that induce bone resorption and impair bone formation. In this work, peptide-coated implants are designed to create a beneficial bone immune microenvironment around prostheses to promote interfacial osteogenesis. By taking advantage of the spontaneous and stable coordination chemistry, Ti-based implants are coated with the mussel-inspired peptide to mitigate lipopolysaccharide (LPS)-induced inflammation by up-regulating the M2 phenotype of macrophages. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120197DOI Listing

Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemo-immunotherapy of colorectal cancer.

Biomaterials 2020 Jun 12;255:120190. Epub 2020 Jun 12.

Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China. Electronic address:

High expression of indoleamine 2,3-dioxygenase 1 (IDO1) is a major cause of tumor induced immunosuppression, and appears to be associated with poor prognosis in human colorectal cancer and some others. In this study, we construct a bifunctional liposome by self-assembly of oxaliplatin-prodrug (Oxa(IV)) conjugated phospholipid and alkylated NLG919 (aNLG), an IDO1 inhibitor, together with other commercial lipids. The obtained aNLG/Oxa(IV)-Lip can not only release cytotoxic oxaliplatin inside the reductive cytosol to trigger immunogenic cell death (ICD) of cancer cells, but also efficiently retard the degradation of tryptophan to immunosuppressive kynurenine via the NLG919 mediated inhibition of IDO1. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120190DOI Listing

Polymerization-induced photothermy: A non-donor-acceptor approach to highly effective near-infrared photothermal conversion nanoparticles.

Biomaterials 2020 Jun 10;255:120179. Epub 2020 Jun 10.

Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou, 350207, China; School of Materials Science and Engineering and Tianjin Key Laboratory of Molecular Optoelectronic Science, Tianjin University, Tianjin, 300072, PR China. Electronic address:

Photothermal conversion nanoagents based on conjugated polymers (CPs) are attracting increasing attention for in vivo disease theranostics and high-performing ones are in urgent pursuit. Herein, we report a new and non-donor-acceptor approach to photothermal conversion CPs that combine several merits including low bandgaps, strong near-infrared absorption, low intersystem crossing rate and non-emissive nature. Three CPs based on 6,7; 6',7'-fused isoindigos (nIIDs), i. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120179DOI Listing

Monocyte mimics improve mesenchymal stem cell-derived extracellular vesicle homing in a mouse MI/RI model.

Biomaterials 2020 Jun 8;255:120168. Epub 2020 Jun 8.

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; Institute of Biomedical Science, Fudan University, Shanghai, China. Electronic address:

Stem cell-derived extracellular vesicles (EVs) have been demonstrated to be effective in heart repair and regeneration post infarction. However, the poor homing efficiency and low yields of these therapeutics remain the major obstacles before they can be used in the clinic. To improve the delivery efficiency of EVs to ischemia-injured myocardium, we modified mesenchymal stem cell (MSC)-derived EVs with monocyte mimics through the method of membrane fusion. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120168DOI Listing

Millimeter-thick xenoislet-laden fibers as retrievable transplants mitigate foreign body reactions for long-term glycemic control in diabetic mice.

Biomaterials 2020 Jun 8;255:120162. Epub 2020 Jun 8.

Institute of Industrial Science (IIS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8505, Japan; Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

Transplantation technologies of pancreatic islets as well as stem cell-derived pancreatic beta cells encapsulated in hydrogel for the induction of immunoprotection could advance to treat type 1 diabetes mellitus, if the hydrogel transplants acquire retrievability through mitigating foreign body reactions after transplantation. Here, we demonstrate that the diameter of the fiber-shaped hydrogel transplants determines both in vivo cellular deposition onto themselves and their retrievability. Specifically, we found that the in vivo cellular deposition is significantly mitigated when the diameter is 1. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120162DOI Listing

Engineering 3D skeletal muscle primed for neuromuscular regeneration following volumetric muscle loss.

Biomaterials 2020 Jun 2;255:120154. Epub 2020 Jun 2.

Translational Tissue Engineering Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA; Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Materials Science & Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology (INBT), Johns Hopkins University School of Engineering, Baltimore, MD 21218, USA. Electronic address:

Volumetric muscle loss (VML) overwhelms the native regenerative capabilities of skeletal muscle and has few effective treatments to regain lost muscle mass and function. Tissue engineered muscle constructs designed to promote neuromuscular regeneration are a promising therapeutic avenue. To date, there has been no engineered muscle construct for VML treatment that has incorporated a pharmacologic agent to promote neuromuscular regeneration. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120154DOI Listing

Porous Pt nanoparticles loaded with doxorubicin to enable synergistic Chemo-/Electrodynamic Therapy.

Biomaterials 2020 Jun 13;255:120202. Epub 2020 Jun 13.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China. Electronic address:

Overexpression of P-glycoprotein (P-gp), which is responsible for pumping chemotherapeutic drugs out of tumor cells, has been recognized as an important cause of drug resistance in conventional chemotherapy. Herein, porous platinum nanoparticles (pPt NPs) are developed to enable the combined electrodynamic therapy (EDT) with chemotherapy. With polyethylene glycol (PEG) coating, the obtained pPt-PEG NPs could be loaded with anticancer drug doxorubicin (DOX) by utilizing the porous structure of pPt NPs. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120202DOI Listing

Bio-orthogonally crosslinked hyaluronate-collagen hydrogel for suture-free corneal defect repair.

Biomaterials 2020 Jun 10;255:120176. Epub 2020 Jun 10.

Ophthalmology, Stanford University School of Medicine, CA, United States; VA Palo Alto Health Care System, Palo Alto, CA, United States; Chemical Engineering, Stanford University, CA, United States. Electronic address:

Biomaterials that mimic corneal stroma could decrease the need for donor corneal tissue and could decrease the prevalence of complications associated with corneal transplantation, including infection and rejection. We developed a bio-orthogonally crosslinked hyaluronate-collagen hydrogel which can fill corneal defects in situ without the need for any sutures, initiators, or catalysts. We studied the effects of biorthogonal crosslinking on the light transmittance of the hydrogel, which was greater than 97% water. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120176DOI Listing

Human adipose-derived stem cell spheroids incorporating platelet-derived growth factor (PDGF) and bio-minerals for vascularized bone tissue engineering.

Biomaterials 2020 Jun 12;255:120192. Epub 2020 Jun 12.

Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, Seoul, 04763, Republic of Korea; BK21 Plus Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, Seoul, 04763, Republic of Korea; Institute of Nano Science and Technology, Hanyang University, Seoul, 04763, Republic of Korea. Electronic address:

Stem cells with mineralized materials have been used for bone regeneration; however, engineering the complex vascularized structure of the natural bone remains a challenge. Here, we developed platelet-derived growth factor (PDGF) and bio-mineral coated fibers which were then assembled with human adipose-derived stem cells (hADSCs) to form spheroids as building blocks for vascularized bone regeneration. The PDGF incorporated within the spheroid increased the proliferation of hADSCs, which was characterized by Ki-67 staining and DNA contents. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120192DOI Listing

Application of conductive PPy/SF composite scaffold and electrical stimulation for neural tissue engineering.

Biomaterials 2020 Jun 6;255:120164. Epub 2020 Jun 6.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, PR China; Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Nantong University, Nantong, 226001, PR China. Electronic address:

Electrical stimulation (ES) with conductive polymers can dramatically enhance neurite outgrowth and promote neural regeneration. However, besides ES, the practical applications of neural repair is also highly dependent on the nerve cell functionality and response to substrate conductivity. Therefore, the combination of the ES and suitable materials, such as tissue scaffolds, has been applied to facilitate treatment of neural injuries and demonstrated great potential in peripheral nerve regeneration. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120164DOI Listing

Phagocyte-membrane-coated and laser-responsive nanoparticles control primary and metastatic cancer by inducing anti-tumor immunity.

Biomaterials 2020 Jun 7;255:120159. Epub 2020 Jun 7.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, PR China. Electronic address:

To achieve safe and effective antitumor immunity, we constructed the M1-macrophage-membrane-coated nanoparticles [(C/I)BP@B-A(D)&M1m] having laser-responsive, size-changeable, on-demand drug release and prolonged circulation retention properties. (C/I)BP@B-A(D)&M1m delayed clearance by the phagocytic system and homed to tumor efficiently. Upon 650 nm laser irradiation, the hydrophobic core of the PEGylated bilirubin nanoparticles (BP) got disrupted, releasing small-sized deep-penetrating B-A(D) particles, photosensitive chlorin e6 (C), and tolerance-inducing indoleamine 2,3-dioxygenase inhibitor, indoximode (I). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120159DOI Listing

A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular HO, and produce large amounts CO for a highly efficient treatment of osteoarthritis.

Biomaterials 2020 Jun 7;255:120155. Epub 2020 Jun 7.

School of Materials Science and Engineering of Nanjing Tech University, China. Electronic address:

Specifically inhibiting the proliferation of activated macrophages and clearing the high levels of reactive oxygen species (ROS) secreted by macrophages is crucial for osteoarthritis (OA) treatment. Moreover, if the clearance of these high levels of ROS can be simultaneously used to induce oxidation-responsive release of anti-inflammatory drugs, the therapeutic effect of OA may be further improved. Here, a multifunctional anti-inflammatory drug (CPHs) based on a peptide dendrimer nanogel was constructed by physically encapsulating CORM-401 and wrapping its surface with folic acid (FA)-modified hyaluronic acid (HA). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120155DOI Listing

Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters.

Biomaterials 2020 Jun 2;255:120166. Epub 2020 Jun 2.

Jiangsu Key Laboratory of Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Suzhou, 215123, China. Electronic address:

The anticancer performance of nanomedicine is largely impeded by insufficient intratumoral penetration. Herein, tumor microenvironment (TME)-amendatory and self-adaptive nanoclusters (NCs) capable of cancer-associated fibroblasts (CAFs) depletion and size/charge conversion were engineered to mediate light-assisted, hierarchical intratumoral penetration. Particularly, large-sized NCs (~50 nm) were prepared via self-assembly of FAP-α-targeting peptide-modified, O-sensitive polymers, which were further used to envelope small-sized dendrimer (~5 nm) conjugated with Ce6 and loaded with DOX (DC/D). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120166DOI Listing

Therapeutic nanovaccines sensitize EBV-associated tumors to checkpoint blockade therapy.

Biomaterials 2020 Jun 6;255:120158. Epub 2020 Jun 6.

Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou, China. Electronic address:

For successful treatment of EBV-associated tumors immune tolerance must be broken. While most studies of EBV-associated tumor vaccines have focused on augmenting tumor-specific effector T cells, the effects of these vaccines on the immune-suppressive tumor microenvironment have not been investigated. Here, we describe the manufacture of a nanovaccine using tannic acid (TA) and a newly constructed protein antigen for EBV-associated tumors with interferon-α (IFN-α) or CpG as adjuvants. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120158DOI Listing

Piezoelectric materials for ultrasound-driven dissociation of Alzheimer's β-amyloid aggregate structure.

Biomaterials 2020 Jun 7;255:120165. Epub 2020 Jun 7.

Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon, 34141, Republic of Korea. Electronic address:

Piezoelectric materials can evoke electrochemical reactions by transferring charge carriers to reactants upon receiving mechanical stimuli. We report a newly discovered function of piezoelectric bismuth oxychloride (BiOCl) nanosheets for dissociating Alzheimer's β-amyloid (Aβ) aggregates through ultrasound-induced redox reactions. The accumulation of Aβ aggregates (e. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120165DOI Listing

MOF-encapsulated nanozyme enhanced siRNA combo: Control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer's disease model.

Biomaterials 2020 Jun 1;255:120160. Epub 2020 Jun 1.

Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, PR China; University of Science and Technology of China, Hefei, Anhui, 230029, PR China. Electronic address:

Neural stem cells (NSC) transplantation is garnering considerable attention in the treatment of neurodegenerative diseases that are associated with cognitive decline. Current methods are mainly based on neuron-directional differentiation and NSC niche components majorization to promote neurogenesis. Unfortunately, the pathologically high level of oxidative stress will damage the neurons derived from NSC during therapy, compromising the neurogenesis effect. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120160DOI Listing

Designing immunogenic nanotherapeutics for photothermal-triggered immunotherapy involving reprogramming immunosuppression and activating systemic antitumor responses.

Biomaterials 2020 May 29;255:120153. Epub 2020 May 29.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China. Electronic address:

Low tumor mutational burden and absence of T cells within the tumor sites are typical characteristics of "cold immune tumors" that paralyzes the immune system. The strategy of reversing "cold tumors" to "hot tumors" infiltrated high degree of T cells in order to activate anti-tumor immunity has attracted lots of attentions. Herein, immunogenic core-shell Au@Se NPs is fabricated by gold-selenium coordination bond to realize nanoparticles-mediated local photothermal-triggered immunotherapy. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120153DOI Listing

Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of CuSe-Au Janus nanoparticles for tri-combination antitumor therapy.

Biomaterials 2020 Jun 5;255:120167. Epub 2020 Jun 5.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China. Electronic address:

In vivo chemical reactions activated by the tumor microenvironment (TME) are particularly promising for antitumor treatments. Herein, employing CuSe-Au Janus nanoparticles (NPs), photothermal conversion-coordinated Fenton-like and photocatalytic reactions are demonstrated in vitro/vivo. The amorphous form of CuSe and the catalytic effect of Au benefit the OH generation, and the photo-induced electron‒hole separation of the Janus NPs produces additional OH. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120167DOI Listing

Renal clearable Hafnium-doped carbon dots for CT/Fluorescence imaging of orthotopic liver cancer.

Biomaterials 2020 Jun 8;255:120110. Epub 2020 Jun 8.

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin, 130022, PR China.

Carbon dots (CDs) are emerging as powerful nanoprobes for multiple-model bioimaging. Nowadays, orthotopic xenograft models attract increasing attention because of their superiorities of duplicating the tumor microenvironment. However, compared with the extensive study of subcutaneous xenograft tumors, less attention has been paid to CDs for in vivo orthotopic tumor imaging. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120110DOI Listing

Hydrogen peroxide-response nanoprobe for CD44-targeted circulating tumor cell detection and HO analysis.

Biomaterials 2020 Jun 8;255:120071. Epub 2020 Jun 8.

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China. Electronic address:

Circulating tumor cells (CTCs) represent the most common way of tumor metastasis and has been considered as a significant index for tumor diagnosis, staging and prognosis. However, CTC detection and analysis are always limited by the scarcity of CTC in the peripheral blood and the interference of blood cells. Therefore, here we presented with a hydrogen peroxide (HO)-response nanoprobes with CD44-targeted ability to reduce the interference of blood cells and improve the detection efficiency and accuracy and the pancreatic cancer cell was used to evaluate the feasibility of our probe. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120071DOI Listing

A bubble bursting-mediated oral drug delivery system that enables concurrent delivery of lipophilic and hydrophilic chemotherapeutics for treating pancreatic tumors in rats.

Biomaterials 2020 Jun 3;255:120157. Epub 2020 Jun 3.

Department of Chemical Engineering/Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:

The therapeutic outcome of pancreatic cancer remains unsatisfactory, despite many attempts to improve it. To address this challenge, an oral drug delivery system that spontaneously initiates an effervescent reaction to form gas-bubble carriers is proposed. These carriers concurrently deliver lipophilic paclitaxel (PTX) and hydrophilic gemcitabine (GEM) in the small intestine. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120157DOI Listing

Biomimetic and estrogenic fibers promote tissue repair in mice and human skin via estrogen receptor β.

Biomaterials 2020 May 28;255:120149. Epub 2020 May 28.

Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA. Electronic address:

The dynamic changes in estrogen levels throughout aging and during the menstrual cycle influence wound healing. Elevated estrogen levels during the pre-ovulation phase accelerate tissue repair, whereas reduced estrogen levels in post-menopausal women lead to slow healing. Although previous reports have shown that estrogen may potentiate healing by triggering the estrogen receptor (ER)-β signaling pathway, its binding to ER-α has been associated with severe collateral effects and has therefore limited its use as a therapeutic agent. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120149DOI Listing

A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications.

Biomaterials 2020 May 22;255:120138. Epub 2020 May 22.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China. Electronic address:

Great efforts have been made to develop suitable bioactive constructs that release growth factors (GFs) in a controlled manner for tissue-regeneration applications. Platelet lysates (PLs) are an affordable source of multiple GFs and other proteins, and show great potential in the wound-healing process. Herein, poly-l-lysine (PLL) and hyaluronic acid (HA) were applied to build free-standing polyelectrolyte multilayer films (PEMs) using the PH-amplified layer-by-layer self-assembly method. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2020.120138DOI Listing