1,420 results match your criteria Biomarkers in medicine[Journal]


HSP90α combined with AFP and TK1 improved the diagnostic value for hepatocellular carcinoma.

Biomark Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, PR China.

We investigated the effect of the combination of heat shock protein 90α (HSP90α), alpha-fetoprotein (AFP) and thymidine kinase 1 (TK1) in the diagnosis of hepatocellular carcinoma (HCC). A total of 409 patients with HCC, 101 patients with benign liver disorder and 78 healthy individuals were retrospectively analyzed. HSP90α level was higher in HCC patients than in controls. Read More

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http://dx.doi.org/10.2217/bmm-2019-0484DOI Listing

Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19.

Biomark Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430021, China.

We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Read More

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http://dx.doi.org/10.2217/bmm-2020-0254DOI Listing

Circular RNAs: new genetic tools in melanoma.

Biomark Med 2020 May 28. Epub 2020 May 28.

Research Center for Biochemistry & Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Melanoma is the most lethal form of skin cancer. New technologies have resulted in major advances in the diagnosis and treatment of melanoma and other cancer types. Recently, some studies have investigated the role of circular RNAs (circRNAs) in different cancers. Read More

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http://dx.doi.org/10.2217/bmm-2019-0567DOI Listing

Integrative meta-analysis for the identification of hub genes in chemoresistant colorectal cancer.

Biomark Med 2020 May 28. Epub 2020 May 28.

UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Cheras 56000, Kuala Lumpur.

Finding a new target or a new drug to overcome chemoresistance is difficult due to the heterogenous nature of cancer. Meta-analysis was performed to combine the analysis of different microarray studies to get a robust discovery. m Herein, we analyzed three microarray datasets on combination of folinic acid, fluorouracil, and oxaliplatin drugs (FOLFOX) resistance that fit our inclusion/exclusion criteria and performed a meta-analysis using the OmiCC system. Read More

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http://dx.doi.org/10.2217/bmm-2019-0241DOI Listing

Application of a machine learning-driven, multibiomarker panel for prediction of incident cardiovascular events in patients with suspected myocardial infarction.

Biomark Med 2020 May 28. Epub 2020 May 28.

Department of Cardiology, University Heart & Vascular Center Hamburg, Hamburg, Germany.

In patients with suspected myocardial infarction (MI), we sought to validate a machine learning-driven, multibiomarker panel for prediction of incident major adverse cardiovascular events (MACE). A previously described prognostic panel for MACE consisting of four biomarkers was measured in 748 patients with suspected MI. The investigated end point was incident MACE within 1 year. Read More

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http://dx.doi.org/10.2217/bmm-2019-0584DOI Listing

How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin.

Biomark Med 2020 May 28. Epub 2020 May 28.

Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy.

The diagnostic and prognostic role of procalcitonin (PCT) and mid-regional-pro-adrenomedullin (MR-proADM) were investigated in patients with pneumonia. A total of 168 and 77 patients with pneumonia enrolled in two different hospital settings, an internal medicine unit and an emergency unit were included in the study. PCT and MR-proADM plasma concentrations and pneumonia severity index score were measured. Read More

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http://dx.doi.org/10.2217/bmm-2019-0414DOI Listing

Osteopontin as novel biomarker for reversibility of pressure overload induced left ventricular hypertrophy.

Biomark Med 2020 May 28. Epub 2020 May 28.

Department of Cardiac Surgery, Heinrich-Heine-University, Medical Faculty, Moorenstraße 5, 40225 Düsseldorf, Germany.

The aim of this study was to evaluate the prognostic value of osteopontin (OPN) as a marker for left ventricular (LV) hypertrophy and its reversibility after surgical aortic valve replacement (SAVR). Echocardiographic data and OPN plasma levels of 149 consecutive patients undergoing SAVR were obtained preoperatively and 3 months postoperatively. OPN was measured by Quantikine Human OPN immunoassay. Read More

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http://dx.doi.org/10.2217/bmm-2019-0410DOI Listing

Clinical significance of miR-33b in glioma and its regulatory role in tumor cell proliferation, invasion and migration.

Biomark Med 2020 May 28. Epub 2020 May 28.

Department of Neurology, Shengli Oilfield Central Hospital, Dongying 257034, Shandong, China.

This study aimed to investigate the clinical significance of microRNA-33b (miR-33b) in glioma patients and its biological function in tumor progression. Expression of miR-33b was measured using quantitative real-time RT-PCR. Diagnostic and prognostic values of miR-33b were assessed by the receiver operating characteristics curve and Kaplan-Meier (KM) survival assay. Read More

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http://dx.doi.org/10.2217/bmm-2019-0455DOI Listing

Prognostic significance of C-MYC dysregulation in esophageal squamous cell carcinoma: a meta-analysis.

Biomark Med 2020 May 28. Epub 2020 May 28.

Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, PR China.

The clinicopathological and prognostic significance of C-MYC dysregulation (amplification or overexpression) in esophageal squamous cell carcinoma (ESCC) remains controversial. Therefore, we performed this meta-analysis to elucidate this relationship. Available studies were retrieved from PubMed, Web of Science, EMBASE and the Cochrane Library, and ten studies with a total of 1432 patients were included in this meta-analysis. Read More

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http://dx.doi.org/10.2217/bmm-2019-0294DOI Listing

The aegis: platelets as biomarkers of tumor progression.

Biomark Med 2020 May 28. Epub 2020 May 28.

School of Anatomical Sciences, Faculty of the Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.

There is increasing awareness that platelets play a significant role in creating a hypercoagulable environment that mediates tumor progression, beyond their classical hemostatic function. Platelets have heterogenic responses to agonists, and differential release and uptake of bioactive molecules may be manipulated via reciprocal cross-talk with cells of the tumor microenvironment. Platelets thus promote tumor progression by enhancing tumor growth, promoting the development of tumor-associated vasculature and encouraging invasion. Read More

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http://dx.doi.org/10.2217/bmm-2019-0514DOI Listing

Cardiovascular disease as a biomarker for an increased risk of COVID-19 infection and related poor prognosis.

Biomark Med 2020 May 19. Epub 2020 May 19.

Interuniversity Center of Phlebolymphology (CIFL). International Research & Educational Program in Clinical & Experimental Biotechnology at the Department of Medical & Surgical Sciences University Magna Graecia of Catanzaro, Viale Europa 88100 Catanzaro, Italy.

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http://dx.doi.org/10.2217/bmm-2020-0201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236792PMC

Thymidine kinase-1 as a biomarker in breast cancer: estimating prognosis and early recognition of treatment resistance.

Biomark Med 2020 May 7. Epub 2020 May 7.

Sandro Pitigliani" Medical Oncology Department, Hospital of Prato, Prato, Italy.

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http://dx.doi.org/10.2217/bmm-2020-0072DOI Listing

Exhaled nitric oxide as a clinical biomarker for choosing biologics for severe asthma treatment.

Biomark Med 2020 May 7. Epub 2020 May 7.

Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Division of the Telese Terme Institute, Telese Terme, Benevento, Italy.

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http://dx.doi.org/10.2217/bmm-2020-0075DOI Listing

Basic knowledge on BCR-ABL1-positive extracellular vesicles.

Biomark Med 2020 Apr 9;14(6):451-458. Epub 2020 Apr 9.

Department of Hematology, Iuliu Hatieganu University of Medicine & Pharmacy, 21 December Boulevard, 400124, Cluj-Napoca, Romania.

Chronic myelogenous leukemia (CML) is a hematological malignancy characterized by the excessive proliferation of myeloid progenitors. In the case of CML, these extracellular vesicles (EVs) were shown to communicate with hematopoietic stem cells, mesenchymal stem cells, myeloid derived suppressor cells and endothelial cells determining a beneficial microenvironment for the CML clone. Moreover, as these EVs are marked through BCR-ABL1, they were shown to be useful in clinical research in determining the grade of molecular remission with further studies being needed to determine if they are better or worse at predicting CML relapse. Read More

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http://dx.doi.org/10.2217/bmm-2019-0510DOI Listing

Associations between gene polymorphisms and dilated cardiomyopathy in a Chinese population.

Biomark Med 2020 Apr 9;14(6):441-450. Epub 2020 Apr 9.

Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.

The present study aimed to investigate the role of gene polymorphisms in dilated cardiomyopathy (DCM) susceptibility and prognosis in a Chinese population. A total of 343 DCM patients and 451 controls were enrolled and had their blood genotyped. Survival analysis was evaluated with Kaplan-Meier curves and Cox regression analysis. Read More

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http://dx.doi.org/10.2217/bmm-2019-0384DOI Listing

Diagnostic value of HOX transcript antisense RNA for cancer detection: a meta-analysis.

Biomark Med 2020 Apr 9;14(5):401-411. Epub 2020 Apr 9.

Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Heifei, China.

Numerous studies have investigated the diagnostic role of long noncoding RNA HOX transcript antisense RNA in cancers, but its diagnostic efficacy is inconsistent. The PubMed, Embase, Web of Science and Cochrane Library databases are used to retrieve relevant studies. The bivariate effect model was used to compute the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under the receiver operating characteristic curve. Read More

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http://dx.doi.org/10.2217/bmm-2019-0207DOI Listing

Cardiac troponin had limited diagnostic value for acute myocardial infarction in renal insufficiency: a meta-analysis.

Biomark Med 2020 Apr 9;14(6):481-493. Epub 2020 Apr 9.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

To evaluate the diagnostic efficiency of cardiac troponin (cTn) for acute myocardial infarction in renal insufficiency patients. Medline, EMBASE and the CENTRAL databases were searched for eligible studies. Thirteen studies were included. Read More

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http://dx.doi.org/10.2217/bmm-2019-0339DOI Listing

Methods for rapid diagnosis of meningitis etiology in adults.

Biomark Med 2020 Apr 9;14(6):459-479. Epub 2020 Apr 9.

Division of Infectious Diseases, Department of Medicine, University of Kansas, Kansas City, KS 66160, USA.

Infectious meningitis can be caused by viral, bacterial or fungal pathogens. Despite widely available treatments, many types of infectious meningitis are still associated with significant morbidity and mortality. Delay in diagnosis contributes to poor outcomes. Read More

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http://dx.doi.org/10.2217/bmm-2019-0333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248681PMC

Biomarkers for pediatric cancer detection: latest advances and future perspectives.

Biomark Med 2020 Apr 9;14(5):391-400. Epub 2020 Apr 9.

Department of Pediatrics, Hematology & Oncology, Medical University of Gdansk, Poland 7 Debinki Street, 80-952 Gdansk, Poland.

Cancer is one of the major health problems of the modern world. With the development of novel biochemistry and analytical instrumentation, precancer diagnosis has become a major focus of clinical and preclinical research. Finding appropriate biomarkers is crucial to make an early diagnosis, before the disease fully develops. Read More

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http://dx.doi.org/10.2217/bmm-2019-0613DOI Listing

Relationship between mild renal dysfunction and coronary artery disease in young patients with stable angina pectoris.

Biomark Med 2020 Apr 9;14(6):433-440. Epub 2020 Apr 9.

Department of Cardiology, Faculty of Hamidiye Medicine, University of Health Science Turkey, Ankara Research & Education Hospital, Ankara, Turkey.

We investigated the relationship between mild renal dysfunction (MRD) and the presence of coronary artery disease (CAD) in people under 60 years of age.  A total of 634 (317 patients with vessel stenosis ≥50% and 317 with normal angiography) individuals diagnosed with stable angina pectoris and estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m were included in the present study. Read More

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http://dx.doi.org/10.2217/bmm-2019-0319DOI Listing

C-reactive protein in saliva and dried blood spot as markers of stress reactivity in healthy African-Americans.

Biomark Med 2020 Apr 7;14(5):371-380. Epub 2020 Apr 7.

Department of Psychology, Wayne State University, 5057 Woodward Ave., Detroit, MI 48202, USA.

Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based social-evaluative stressor task. Read More

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http://dx.doi.org/10.2217/bmm-2019-0391DOI Listing

Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer.

Biomark Med 2020 Apr 7;14(5):353-369. Epub 2020 Apr 7.

Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Prostate cancer (PCa) is the sixth leading cause of cancer-related deaths in men throughout the world. This study aimed to investigate genes associated with the pathogenesis and prognosis of PCa. Data of PCa cases were obtained from public datasets and were analyzed using an integrated bioinformatics strategy. Read More

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http://dx.doi.org/10.2217/bmm-2019-0318DOI Listing

Predictive and patient-monitoring biomarkers: precision in the management of colorectal cancer.

Biomark Med 2020 Apr 6;14(5):335-339. Epub 2020 Apr 6.

Centre for Biosystems and Genome Network Medicine, Ioannina University, Ioannina, Greece.

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http://dx.doi.org/10.2217/bmm-2020-0025DOI Listing

expression and its epigenetic regulation as biomarkers for insulin resistance treatment in diabetes mellitus.

Biomark Med 2020 Apr 6;14(6):413-416. Epub 2020 Apr 6.

Department of Physiology & Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.2217/bmm-2019-0481DOI Listing

The role of epithelial-mesenchymal transition markers in the prediction of lymph node metastases in colorectal cancer.

Biomark Med 2020 Apr 6;14(6):417-420. Epub 2020 Apr 6.

Department of Cell & Molecular biology, Faculty of Science, Tehran University of Medical Science, Tehran, Iran.

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http://dx.doi.org/10.2217/bmm-2019-0420DOI Listing

Circulating tumor-specific DNA: a stony road to clinical utility.

Biomark Med 2020 Apr 6;14(5):331-333. Epub 2020 Apr 6.

Danish Colorectal Cancer Center South, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.

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http://dx.doi.org/10.2217/bmm-2019-0552DOI Listing

The performance of the / methylation assay is influenced by cancer stage, age, type and differentiation.

Biomark Med 2020 Apr 6;14(5):341-351. Epub 2020 Apr 6.

Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.

To investigate the clinicopathological factors affecting the assay performance and its application in lung cancer detection in Chinese population. A total of 455 subjects were recruited in this case-control study (302 untreated lung cancer patients, 153 normal subjects). Blood samples were collected before therapy and the level was measured with Epi proLung assay. Read More

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http://dx.doi.org/10.2217/bmm-2019-0325DOI Listing
April 2020
2.858 Impact Factor

Prognostic value of methylation and expression in lung squamous cell carcinoma.

Biomark Med 2020 Mar 25. Epub 2020 Mar 25.

Department of Research, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, PR China.

This study aimed to analyze the prognostic value and clinical significance of mRNA expression and methylation in lung squamous cell carcinoma (LUSC). The mRNA expression and methylation of data of LUSC patients were downloaded from the Broad GDAC Firehose database and analyzed. mRNA expression was downregulated and methylation was upregulated in LUSC tissue. Read More

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http://dx.doi.org/10.2217/bmm-2020-0054DOI Listing

promotes metastasis and predicts prognosis in gastric cancer via regulating mTOR.

Biomark Med 2020 Apr 16;14(6):421-432. Epub 2020 Mar 16.

Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, PR China.

Gastric cancer (GC) is one of the most common malignant tumors in the world. It is important to find accurate and reliable biomarkers in order to decrease whole morbidity and mortality. We examined the expression of and on GC tissue microarrays by immunohistochemistry. Read More

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http://dx.doi.org/10.2217/bmm-2019-0357DOI Listing

Mean platelet volume/platelet count ratio predicts long-term mortality in patients with infective endocarditis.

Biomark Med 2020 Mar 13;14(4):293-302. Epub 2020 Mar 13.

Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China.

We aimed to examine the association between baseline mean platelet volume/platelet count ratio (MPR) and all-cause mortality in patients with infective endocarditis (IE). This study analyzed 218 consecutive patients with IE and divided them into four groups based on MPR quartiles. We used Kaplan-Meier survival curves to determine the cumulative survival and Cox proportional hazards models to investigate the association between MPR and all-cause mortality after hospital discharge. Read More

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http://dx.doi.org/10.2217/bmm-2019-0258DOI Listing

Prognostic value of cripto-1 expression in non-small-cell lung cancer patients: a systematic review and meta-analysis.

Biomark Med 2020 Mar 5;14(4):317-329. Epub 2020 Mar 5.

Department of Pathology, The First Affiliated Hospital to Shihezi University School of Medicine, Shihezi University School of Medicine, Shihezi 832002, Xinjiang, China.

This systematic review and meta-analysis aimed to analyze the association between cripto-1 expression and prognosis as well as clinicopathological features of non-small-cell lung cancer (NSCLC) patients. The electronic databases for all articles about NSCLC and cripto-1 expression were searched. Twelve articles were enrolled in this meta-analysis (3130 samples). Read More

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http://dx.doi.org/10.2217/bmm-2019-0159DOI Listing

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for the diagnosis and prognosis in patients with restenosis following CAS.

Biomark Med 2020 Mar 5;14(4):271-282. Epub 2020 Mar 5.

Department of Neurosurgery, Jinhua Municipal Central Hospital, Zhejiang University School of Medicine, Jinhua 321000, Zhejiang Province, China.

In this study, we investigated the effect of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio on restenosis status in patients undergoing carotid angioplasty stenting (CAS). Clinical imageology and receiver operating characteristic analysis were utilized to study the prognostic significance of NLRs/platelet-to-lymphocyte ratios and their correlation with survival. NLR of restenosis (+) patients was evidently increased after the CAS procedures, while the NLR of restenosis (-) patients before the CAS procedures being the lowest. Read More

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http://dx.doi.org/10.2217/bmm-2019-0155DOI Listing

Significance of lncRNA in predicting the prognosis for Chinese patients with cancer: a meta-analysis.

Biomark Med 2020 Mar 5;14(4):303-316. Epub 2020 Mar 5.

Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

It is important to clarify the significance of long noncoding RNA MIR31 host gene (lncRNA ) in predicting the prognosis for malignant tumors through meta-analysis. Electronic databases were systemically searched, from inception until 2 January 2019, to identify related articles. Meanwhile, the hazard ratios (odds ratios) and 95% CIs were computed for exploring the association between the expression of lncRNA and the survival (pathological variables). Read More

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http://dx.doi.org/10.2217/bmm-2019-0145DOI Listing

Mean corpuscular hemoglobin concentration correlates with prognosis of resected hepatocellular carcinoma.

Biomark Med 2020 Mar 5;14(4):259-270. Epub 2020 Mar 5.

Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

To evaluate the prognostic role of mean corpuscular hemoglobin concentration (MCHC) in hepatocellular carcinoma (HCC) after hepatectomy. A total of 289 HCC patients were classified into two groups based on the cut-off value of MCHC. Significant prognostic factors were screened by univariate and multivariate analysis. Read More

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http://dx.doi.org/10.2217/bmm-2019-0224DOI Listing

Interaction analysis of with the susceptibility to hepatocellular carcinoma.

Biomark Med 2020 Mar 5;14(4):283-292. Epub 2020 Mar 5.

School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, China.

The aim of this study was to investigate the association of miR-1275 rs16759, rs11079850 and rs34414305 with hepatocellular carcinoma (HCC) risk. Genotyping of the rs16759 and rs11079850 was performed using a Taqman assay and genotyping of the rs34414305 was performed using PCR. Relative expression of miR-1275, and was examined using quantitative PCR. Read More

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http://dx.doi.org/10.2217/bmm-2019-0332DOI Listing
March 2020
2.858 Impact Factor

Predictive biomarkers for molecular pathology in lung cancer.

Biomark Med 2020 Mar 3;14(4):253-257. Epub 2020 Mar 3.

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.2217/bmm-2019-0490DOI Listing

The emerging role of carbohydrate antigen 125 in heart failure.

Biomark Med 2020 Mar 3;14(4):249-252. Epub 2020 Mar 3.

Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain.

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http://dx.doi.org/10.2217/bmm-2019-0470DOI Listing

Elevated serum sortilin is related to carotid plaque concomitant with calcification.

Biomark Med 2020 Apr 20;14(5):381-389. Epub 2020 Feb 20.

Department of Cardiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, PR China.

To explore whether elevated serum sortilin was associated with calcified carotid plaque and ischemic stroke. A total of 171 patients with cardiovascular risk factors were enrolled. Ultrasonography was performed to evaluate calcified plaques and noncalcified plaques. Read More

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http://dx.doi.org/10.2217/bmm-2019-0472DOI Listing

Tears - more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease.

Biomark Med 2020 02 17;14(2):151-163. Epub 2020 Feb 17.

Department of Ophthalmology and Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Tears are a known source of biomarkers for both ocular and systemic diseases with particular advantages; specifically, the noninvasiveness of sample collection and a unique and increasingly better-defined protein composition. Here, we discuss our rationale for use of tears for discovery of biomarkers for Parkinson's disease (PD). These reasons include literature supporting changes in tear flow and composition in PD, and the interconnections between the ocular surface system and neurons affected in PD. Read More

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http://dx.doi.org/10.2217/bmm-2019-0364DOI Listing
February 2020

Discovery of candidate gene expression signatures in peripheral blood for the screening of cervical cancer.

Biomark Med 2020 02 17;14(2):109-118. Epub 2020 Feb 17.

Department of Biotechnology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.

To investigate whether cervical cancer (CC) and cervical intraepithelial neoplasia (CIN) can be screened by analyzing gene expression profiling of peripheral blood. RNA-sequencing analysis of blood was performed on 11 CC patients, 21 CIN patients and 19 healthy controls (H). Fifty-nine genes were validated by quantitative real-time PCR using blood samples from 46 H, 83 CC and 32 CIN patients. Read More

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http://dx.doi.org/10.2217/bmm-2019-0247DOI Listing
February 2020

Exosomes-microRNAs interacted with gastric cancer and its microenvironment: a mini literature review.

Biomark Med 2020 02 17;14(2):141-150. Epub 2020 Feb 17.

The Department of Clinical Laboratory, Affiliated Kunshan Hospital of Jiangsu University, Kunshan 215300, Jiangsu, People's Republic of China.

Exosomes have appeared as fundamental vehicle-modulated crosstalk among various cells in the tumor microenvironment. The systematic understanding of exosomes in gastric cancer (GC) enhances our comprehension about the tumor growth, metastasis, chemoresistance and diagnosis of cancers. The versatile functions of exosomes provide reasonable explanations about the propensity for GC metastasis. Read More

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http://dx.doi.org/10.2217/bmm-2019-0387DOI Listing
February 2020

Serum metabolic characteristics and biomarkers of early-stage heart failure.

Biomark Med 2020 02 14;14(2):119-130. Epub 2020 Feb 14.

Department of Forensic Medicine, Shantou University Medical College, Shantou 515041, China.

We aimed to identify metabolic characteristics of early-stage heart failure (HF) and related biomarkers. One hundred and forty-three patients with New York Heart Association class I-IV HF and 34 healthy controls were recruited. Serum metabolic characteristics of class I HF were analyzed and compared with those of class II-IV HF. Read More

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http://dx.doi.org/10.2217/bmm-2019-0176DOI Listing
February 2020

Prevalence and determinants of elevated D-dimer in patients with hypertrophic cardiomyopathy.

Biomark Med 2020 02 14;14(2):131-140. Epub 2020 Feb 14.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To evaluate D-dimer levels in patients with hypertrophic cardiomyopathy (HCM). A total of 346 patients with HCM were recruited. Plasma D-dimer was determined by clinical laboratory of our hospital. Read More

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http://dx.doi.org/10.2217/bmm-2019-0225DOI Listing
February 2020

Urine: an overlooked biomedium in heart failure?

Biomark Med 2020 Feb 14;14(3):165-168. Epub 2020 Feb 14.

Cardiology Department, Hospital Clínico Universitario de Valencia, Universitat de Valencia, INCLIVA, Valencia, Spain.

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http://dx.doi.org/10.2217/bmm-2019-0433DOI Listing
February 2020

Synergistic effect of sclerostin and angiotensin II receptor 1 polymorphism on arterial stiffening.

Biomark Med 2020 Feb 14;14(3):173-184. Epub 2020 Feb 14.

2nd Department of Internal Medicine, Medical Faculty of Charles University and University Hospital, Pilsen, Czech Republic.

We aimed to establish the association between sclerostin (a glycoprotein involved in bone metabolism) and development of pulse wave velocity (PWV) in the general population. A prospective cohort study with a total of 522 subjects. Aortic PWV was measured twice (at baseline and after approximately 8 years of follow-up) and intraindividual change in PWV per year (ΔPWV/year) was calculated. Read More

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http://dx.doi.org/10.2217/bmm-2019-0249DOI Listing
February 2020

Bioimpedance vector analysis in the evaluation of congestion in heart failure.

Biomark Med 2020 02 13;14(2):81-85. Epub 2020 Feb 13.

Department of Cardiology, Hospital 'F. Perinei' Altamura, Altamura, Apulia, Italy.

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http://dx.doi.org/10.2217/bmm-2019-0429DOI Listing
February 2020

Prognostic significance of neutrophil-to-lymphocyte ratio in several malignancies: where do we stand?

Biomark Med 2020 Feb 13;14(3):169-172. Epub 2020 Feb 13.

Deparment of Neurosurgery, University of Ioannina School of Medicine, Ioannina, Greece.

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http://dx.doi.org/10.2217/bmm-2019-0497DOI Listing
February 2020
2.858 Impact Factor

Genetic biomarkers in chronic venous disease.

Biomark Med 2020 02 13;14(2):75-80. Epub 2020 Feb 13.

Department of Health Sciences, University Magna Graecia of Catanzaro, Viale Europa 88100 Catanzaro, Calabria, Italy.

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http://dx.doi.org/10.2217/bmm-2019-0408DOI Listing
February 2020
2.858 Impact Factor

MiR-485-5p as a potential biomarker and tumor suppressor in human colorectal cancer.

Biomark Med 2020 Feb 27;14(3):239-248. Epub 2020 Jan 27.

Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China.

To investigate the role of miR-485-5p in colorectal cancer (CRC). The level of miR-485-5p in serum and cell lines were measured by quantitative real-time polymerase chain reaction, and analyzed the diagnostic and prognostic value. Additionally, the biological effect of miR-485-5p on CRC cells was also explored . Read More

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http://dx.doi.org/10.2217/bmm-2019-0534DOI Listing
February 2020

Systematic investigation of the prognostic value of cell division cycle-associated proteins for clear cell renal cell carcinoma patients.

Biomark Med 2020 Feb 20;14(3):223-238. Epub 2020 Jan 20.

Department of Urology, The First Affiliated Hospital of Anhui Medical University; Institute of Urology & Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, Anhui, P.R. China.

To explore the prognostic value of the cell division cycle-associated proteins (CDCA) family in clear cell renal cell carcinoma. Gene profiles were collected from the The Cancer Genome Atlas-Kidney Renal Clear Cell Carcinoma (TCGA-KIRC), the GSE29609 and GSE22541 datasets. Genetic alteration and DNA methylation data were downloaded from the cBioPortal and MethSurv. Read More

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http://dx.doi.org/10.2217/bmm-2019-0498DOI Listing
February 2020