1,251 results match your criteria Biomarkers in medicine[Journal]


Neural activities are unfavorable for the prognosis of ovarian cancer through mRNA expression analysis.

Biomark Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Gynecological Oncology, The First Hospital of Jilin University, Changchun, China.

Aim: Ovarian cancer (OC) is the leading lethal gynecological cancer in women worldwide. Understanding the molecular mechanism of OC is very important for the identification of highly sensitive biomarkers for its prognosis.

Methodology: We detected prognostic-related mRNA of OC in OncoLnc database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2019-0056DOI Listing

Advanced glycation end products as biomarkers in systemic diseases: premises and perspectives of salivary advanced glycation end products.

Biomark Med 2019 Apr 10. Epub 2019 Apr 10.

Department of Oral Rehabilitation, Oral Health & Dental Office Management, Faculty of Dentistry, 'Iuliu Haţieganu' University of Medicine & Pharmacy Cluj-Napoca, Romania, Victor Babe? Street, no 15, 400012, Romania.

Advanced glycation end products (AGEs) are glycated proteins associated with high dry temperature food processing, coloring and flavor modification of food products. Previous studies on diet-related disease support the role of the glycation products as biomarkers in local and general proinflammatory response. Exogenous and endogenous AGEs are involved in chronic low-level inflammation, which underlies the onset of metabolic syndrome influenced by food intake, there by demonstrating their implication in diet-related pathologies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0448DOI Listing
April 2019
1 Read

CD44 epithelial isoform inversely associates with invasive characteristics of colorectal cancer.

Biomark Med 2019 Apr 3. Epub 2019 Apr 3.

Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Aim: There is no consensus regarding the clinical significance of CD44 and CD24 as cancer stem cell (CSC) marker in colorectal cancer (CRC).

Methodology: A total of 494 CRC samples (2008-2017) were assessed for CD44 (epithelial isoform) and CD24 expression using tissue microarray.

Results: CD24 individually or in combination with CD44 was not associated with any of the clinicopathologic characteristics of the tumor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0337DOI Listing
April 2019
1 Read

Cardiac troponins as biomarkers for cardiac disease.

Biomark Med 2019 Apr 3. Epub 2019 Apr 3.

Fondazione CNR Regione Toscana G Monasterio & Scuola Superiore Sant'Anna, Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2019-0039DOI Listing
April 2019
1 Read

Association between AXIN1 gene polymorphisms and epithelial ovarian cancer in Chinese population.

Biomark Med 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.

Aim: The study was aimed to explore the association between AXIN1 gene polymorphism and epithelial ovarian cancer (EOC) susceptibility as well as prognosis.

Methods: A total of 165 EOC cases and 327 healthy controls were recruited to participate in this study. In total three tag SNPs in AXIN1 gene were genotyped using PCR-restriction fragment length polymorphism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0306DOI Listing
April 2019
2 Reads
2.858 Impact Factor

Pharmacodynamic monitoring using biomarkers to individualize pharmacotherapy.

Biomark Med 2019 Mar 29. Epub 2019 Mar 29.

Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong.

Drug doses are often titrated upon their clinical effects (e.g., blood pressure). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0355DOI Listing

Accuracy of mRNA HPV tests as a predictor of recurrence of precursor lesions and cervical cancer after conization: a systematic review and meta-analysis.

Biomark Med 2019 Mar 29. Epub 2019 Mar 29.

Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC 88806-000, Brazil.

Objective: This systematic review evaluates the accuracy of mRNA HPV biomarker for the identification of cervical intra-epithelial neoplasia (CIN) or cervical cancer during a follow-up after conization, taking histopathology as reference standard.

Methods: A search of electronic databases was performed, for studies published until June 2018. As results, after screening, five studies including 1148 patients met the inclusion criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0373DOI Listing
March 2019
2 Reads

The role of the tubular biomarkers NAG, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with chest pain before contrast media exposition.

Biomark Med 2019 Mar 28. Epub 2019 Mar 28.

Abteilung für Kardiologie, Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Regensburg, Deutschland.

Aim: We evaluated the role of the tubular biomarkers N-acetyl-ß-D-glucosaminidase (NAG), kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with chest pain.

Methods: Serum and urine samples were collected of 223 patients and 47 healthy controls. None of them was exposed to contrast media. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0275DOI Listing
March 2019
1 Read

Endothelial biomarkers in the light of new sepsis definition.

Biomark Med 2019 Mar 28. Epub 2019 Mar 28.

Faculty of Medicine, Department of Hematology, Hemostasis, & Prevention of Thrombosis, University of Novi Sad, Clinical Center of Vojvodina, Laboratory Medicine Center,  Novi Sad, Serbia.

Aim: The aim of our study was to compare usefulness of endothelial biomarkers for severity and outcome prediction in patients with positive Sepsis-3 criteria with traditionally used biomarkers.

Methods: A total of 150 patients were included in our study. Patients were divided into two groups: patients with sepsis and those with infectious systemic inflammatory response syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0282DOI Listing
March 2019
1 Read

Biomarkers of nondipper hypertension in prehypertensive and hypertensive patients.

Biomark Med 2019 Mar 28. Epub 2019 Mar 28.

Ankara Numune Education and Research Hospital, University of Health Sciences, Ankara, Turkey Istanbul Umraniye Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Aim: The aim of this study was to evaluate the relation of gamma glutamyl transferase (GGT), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with nondipper hypertension.

Methods: This study included a total of 409 patients. Patients were grouped into hypertension, prehypertension and normotensive groups, according to their clinical blood pressure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0247DOI Listing

N-terminal probrain natriuretic peptide as biomarker for diagnosis of Kawasaki disease.

Biomark Med 2019 Mar 22;13(4):307-323. Epub 2019 Mar 22.

Pediatric Department, Puerta del Mar University Hospital, Cadiz 11011 Spain.

Kawasaki disease (KD) is a systemic childhood vasculitis with peculiar tropism for the heart. Coronary artery aneurysms are the primary cause of morbidity and mortality in these patients. The timely administration of gammaglobulin decreases the risk for development of coronary artery aneurysms, highlighting the importance of early KD recognition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0324DOI Listing
March 2019
1 Read

Association of paraoxonase-1 L55M and Q192R polymorphisms with PCOS risk and potential risk factors for atherosclerosis.

Biomark Med 2019 Mar 22;13(4):279-289. Epub 2019 Mar 22.

Department of Pediatrics, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

Aim: To examine the PON1-L55M and -Q192R polymorphisms for polycystic ovary syndrome (PCOS) risk in relation with atherosclerosis risk markers.

Methods: Blood samples were collected from 203 women (PCOS [n = 151], control [n = 52]). Genomic DNA was extracted and RFLP method was performed following the amplifications of the target regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0271DOI Listing
March 2019
1 Read

Methylcrotonoyl-CoA carboxylase 2 overexpression predicts an unfavorable prognosis and promotes cell proliferation in breast cancer.

Biomark Med 2019 Mar 21. Epub 2019 Mar 21.

Heze Municipal Hospital, Heze City, Shandong province 276800, PR China.

Aim:  Methylcrotonoyl-CoA carboxylase 2 (MCCC2), a  subunit of 3-Methylcrotonyl-CoA carboxylase (MCC), is reported to be involved in tumor formation and development. However, the role of MCCC2 in breast cancer is unknown.

Materials & Methods: MCCC2 expression was examined in 138 cases of breast cancer and matched adjacent normal tissues by quantitative reverse transcription PCR and immunohistochemistry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0475DOI Listing
March 2019
1 Read

Surface tension and intrinsic amyloid fluorescence of serum and cerebrospinal fluid samples in Alzheimer´s disease.

Biomark Med 2019 Mar 19;13(4):267-277. Epub 2019 Mar 19.

National Institute of Mental Health, Topolova 748, 250 67 Klecany, Czech Republic.

Aim: Surface tension of biological fluids can be influenced by changes in oligomerization or aggregation of surfactant peptides or proteins. Amphiphilic peptides of amyloid-β or other amyloidogenic peptides/proteins display properties of surfactants, oligomerization and aggregation increase also their fluorescence intensity compared with native structures. Results/methodology: We estimated surface tension and native/ThioflavinT-based/intrinsic amyloid fluorescence intensity in serum and cerebrospinal fluid samples for their evalution as diagnostic biomarkers for Alzheimer´s disease (AD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0319DOI Listing
March 2019
2 Reads

Biomarkers in clinical management of pulmonary hypertension: has the emperor no clothes? A call for action.

Biomark Med 2019 Mar 18;13(4):235-238. Epub 2019 Mar 18.

Pulmonary Rehabilitation Unit, Maugeri Clinical & Scientific Institutes ICSR, Telese (BN), Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0491DOI Listing
March 2019
1 Read

Loss of the tRNA encoding gene, Chr-11 tRNA-Lys-CUU, is not associated with Type 2 diabetes mellitus.

Biomark Med 2019 Mar 18;13(4):259-266. Epub 2019 Mar 18.

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science & Technology, 08028 Barcelona, Catalonia, Spain.

Aim: To investigate the presence/absence of the Chr-11 tRNA-Lys-CUU gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM).

Methods: We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0322DOI Listing

Forms of diagnostic material as sources of miRNA biomarkers in hepatocellular carcinoma: a preliminary study.

Biomark Med 2019 Mar 11. Epub 2019 Mar 11.

Department of Medical Biochemistry, Medical University of Lodz, Mazowiecka Street 6/8 92-215 Lodz, Poland.

Aim: To assess the diagnostic value of selected miRNAs from various material collected from hepatocellular carcinoma (HCC) patients.

Patients & Methods: Tissue, serum, urine and fecal samples from HCC patients and healthy individuals were screened for associated miRNAs using microarray analysis; the selected miRNAs were then validated by real time-quantitative PCR on 65 patients.

Results: Serum miR-122, a combination of serum miR-155 with miR-885-5p, a combination of urinary miR-532-3p with miR-765, and fecal miR-320a displayed 100% efficiency in discriminating patients from controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0485DOI Listing

Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery.

Biomark Med 2019 Feb 27;13(3):205-218. Epub 2019 Feb 27.

Vascular Biology, Cardiovascular Sciences, National Heart & Lung Institute Division, Faculty of Medicine, Imperial College London, London, SW3 6LY, UK.

Aim: We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB).

Patients & Methods: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB.

Results: All markers increased significantly post-CPB with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI within 7 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0238DOI Listing
February 2019

Clinicopathological and prognostic significance of octamer-binding transcription factor 4 in patients with gastric cancer: a systematic review and meta-analysis.

Biomark Med 2019 Feb 27;13(3):219-234. Epub 2019 Feb 27.

The First Hospital of Qiqihaer City, Qiqihaer, Heilongjiang, 161005, PR China.

Aim: The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC.

Materials & Methods: Relevant articles were retrieved from a diverse number of databases, and meta-analysis was completed using STATA software 12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0086DOI Listing
February 2019

Galectin-3 is associated with arterial stiffness among hemodialysis patients.

Biomark Med 2019 Feb 27. Epub 2019 Feb 27.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, PR China.

Aim: To evaluate the association between galectin-3 and arterial stiffness among hemodialysis patients.

Methods: We enrolled 311 patients (median age: 61 years) with a median hemodialysis time of 90 months and a mean galectin-3 concentration of 29.78 ng/ml. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0488DOI Listing
February 2019
2.858 Impact Factor

Analysis of long noncoding RNAs for acute rejection and graft outcome in kidney transplant biopsies.

Biomark Med 2019 Feb 26;13(3):185-195. Epub 2019 Feb 26.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, PR China.

Aim: To analyse long noncoding RNAs (lncRNA) in kidney transplant biopsies.

Methods: Using a data mining approach, we constructed expression profiles in kidney transplant cohorts (n = 1105) from Gene Expression Omnibus. Integrative analysis of the lncRNAs with acute rejection (AR), T-cell-mediated acute rejection (TCMR) and graft loss were performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0272DOI Listing
February 2019
2.858 Impact Factor

Circulating biomarkers for high-grade glioma.

Biomark Med 2019 Feb 26;13(3):161-165. Epub 2019 Feb 26.

Radiation Oncology Branch, National Cancer Institute, 9000 Rockville Pike, Building 10 B3B55, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0463DOI Listing
February 2019
1 Read

Potential biomarkers for antidiastole of tuberculous and malignant pleural effusion by proteome analysis.

Biomark Med 2019 Feb 22;13(2):123-133. Epub 2019 Feb 22.

Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.

Aim: To investigate novel potential biomarkers for antidiastole of tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE).

Materials & Methods: iTRAQTM-coupled LC-MS/MS were applied to analyze the proteome of TPE and MPE samples. The candidate proteins were verified by enzyme-linked immunosorbent assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0200DOI Listing
February 2019
2 Reads

Micro-RNA335-5p targeted inhibition of sKlotho and promoted oxidative stress-mediated aging of endothelial cells.

Biomark Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Geriatrics/West China hospital of SCU, Chengdu, China.

Aim: MiR-335-5p expression might induce endothelial cells (ECs) aging and target inhibit sKlotho. This study aimed to investigate whether oxidative stress evoked miR-335-5p expression and whether miR-335-5p-regulated ECs function through sKlotho.

Methods: The expression of miR-335-5p was detected in human umbilical vein endothelial cells treated with HO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0430DOI Listing
February 2019
1 Read
2.858 Impact Factor

hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.

Biomark Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, People's Republic of China.

Aim: To assess whether expression of circular RNAs (circRNAs) in peripheral blood mononuclear cells can serve as a biomarker for diagnosis and/or therapeutic response in people living with schizophrenia (SZ).

Materials & Methods: Differentially expressed circRNAs were screened via microarray in nine individuals living with SZ and nine healthy controls, then quantified using real-time quantitative reverse transcription PCR in SZ (n = 102) and healthy control (n = 103) groups. CircRNAs were re-assessed twice in 30 randomly selected individuals living with SZ after 4- and 8-week antipsychotic treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0447DOI Listing
February 2019
3 Reads

Pancreatic cancer biomarker detection by two support vector strategies for recursive feature elimination.

Biomark Med 2019 Feb 15;13(2):105-121. Epub 2019 Feb 15.

Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China.

Aim: Pancreatic cancer is one of the worst malignant tumors in prognosis. Therefore, to reduce the mortality rate of pancreatic cancer, early diagnosis and prompt treatment are particularly important.

Results: We put forward a new feature-selection method that was used to find clinical markers for pancreatic cancer by combination of Support Vector Machine Recursive Feature Elimination (SVM-RFE) and Large Margin Distribution Machine Recursive Feature Elimination (LDM-RFE) algorithms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0273DOI Listing
February 2019
1 Read

Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer.

Biomark Med 2019 Feb 15;13(2):95-104. Epub 2019 Feb 15.

Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430000, PR China.

Aim: To assess SLC6A6 expression in gastric cancer, its correlation with patients' clinicopathological features and survival, and the possible epigenetic regulation mechanism.

Methods: Expression profiles and methylation data were obtained from the Gene Expression Omnibus database and the Cancer Genome Atlas. The SLC6A6's protein level were obtained from the Human Protein Atlas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0256DOI Listing
February 2019
1 Read

Preoperative CA125 value predicts Glisson capsule involvement in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Biomark Med 2019 Feb 13. Epub 2019 Feb 13.

Department of General Surgery, University of Health Sciences Kanuni Sultan Suleyman Training & Research Hospital, Istanbul, Turkey.

Aim: The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis.

Methods: The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2019-0009DOI Listing
February 2019
1 Read

N-terminal of the prohormone brain natriuretic peptide is a predictor of hemodynamic instability in valve disease.

Biomark Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.

Aim: The usefulness of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) as a predictor of perioperative hemodynamic instability is not fully elucidated.

Methods: This prospective study was conducted on a group of 455 patients undergoing elective heart valve surgery. The primary end point at the 30-day follow-up was postoperative hemodynamic instability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2019-0002DOI Listing
February 2019
1 Read

The association of estimated whole blood viscosity with hemodynamic parameters and prognosis in patients with heart failure.

Biomark Med 2019 Feb 23;13(2):69-82. Epub 2019 Jan 23.

Cardiology Department, Turkey Yuksek Ihtisas Training & Research Hospital, Ankara, Turkey.

Aim: We aimed to investigate the association of estimated whole blood viscosity (WBV) with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction.

Materials & Methods: Total of 542 patients were included and followed-up for median 13 months.

Results: The WBV parameters had negative relationship with right atrium pressure and positive correlation with cardiac index. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0309DOI Listing
February 2019
3 Reads

Measurement of pancreatic stone protein in the identification and management of sepsis.

Biomark Med 2019 Feb 23;13(2):135-145. Epub 2019 Jan 23.

Abionic SA, Route de la Corniche 5, 1066 Epalinges, Switzerland.

Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection resulting in multiple organ dysfunctions. Early diagnosis and management of sepsis is key to improve patient outcome but remains challenging. Despite extensive research, only few biomarkers have so far proven to be helpful in the diagnosis of sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0194DOI Listing
February 2019

Biomarkers for the prediction of cardiac readmission.

Biomark Med 2019 Feb 23;13(2):55-58. Epub 2019 Jan 23.

The Dartmouth Institute for Health Policy & Clinical Practice, Geisel School of Medicine, Lebanon, NH 03756, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0381DOI Listing
February 2019

The use of serum zinc to prostate-specific antigen ratio as a biomarker in the prediction of prostate biopsy outcomes.

Biomark Med 2019 Feb 23;13(2):59-68. Epub 2019 Jan 23.

Department of Urology, Bagcilar Training & Research Hospital, Merkez Mah, Dr Sadık Ahmet Cad, Bagcilar/Istanbul, Catalca/Istanbul, Turkey.

Aim: To generate a combination of serum zinc (Zn) and prostate-specific antigen (PSA) in an attempt to provide better prediction of prostate biopsy outcomes with Zn/PSA ratios.

Materials & Methods: Diagnostic performances of PSA and Zn/PSA were investigated using receiver operating characteristic and the area under the curve analysis and McNemar test in 480 men. Decision curve analysis was also used to determine the net clinical benefits of the two parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0260DOI Listing
February 2019
1 Read

The intricate role of miR-155 in carcinogenesis: potential implications for esophageal cancer research.

Biomark Med 2019 Feb 23;13(2):147-159. Epub 2019 Jan 23.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

MiRNAs have immerged as essential modulators of key cellular procuresses involved in post-transcriptional regulation of the human transcriptome. They are essential components of complex regulatory networks that modulate most important physiological functions of cells. MicroRNA-155 (miR-155) is a multifaceted regulator of cell proliferation, cell cycle, development, immunity and inflammation that plays pivotal, and sometimes contradictory, roles in numerous cancers including esophageal cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0127DOI Listing
February 2019
61 Reads
2.858 Impact Factor

RAB27A is an independent prognostic factor in clear cell renal cell carcinoma.

Biomark Med 2019 Mar 21;13(4):239-247. Epub 2019 Jan 21.

Gyeongsang National University School of Medicine, Jinju, Korea.

Aim: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC).

Materials & Methods: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated.

Results: The T stage showed a significant correlation with RAB27A intensity (p < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0336DOI Listing
March 2019
2 Reads

Mitochondrial DNA deletions accurately detect endometriosis in symptomatic females of child-bearing age.

Biomark Med 2019 Mar 15;13(4):291-306. Epub 2019 Jan 15.

MDNA Life Sciences UK, The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne, NE4 5BX, UK.

Aim: Accurate noninvasive diagnostic aids for endometriosis are needed. We evaluated mitochondrial DNA deletions as potential biomarkers for endometriosis.

Methods: The diagnostic accuracy of deletions was evaluated by quantitative polymerase chain reaction (QPCR) using well-characterized clinical specimens from all subtypes and stages of endometriosis in a case-control format (n = 182). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0419DOI Listing
March 2019
2 Reads

Initial platelet-to-lymphocyte count as prognostic factor in limited-stage small cell lung cancer.

Biomark Med 2019 Mar 9;13(4):249-258. Epub 2019 Jan 9.

Radiation Oncology Department of Thoracic Cancer, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Liaoning, Shenyang 110042, PR China.

Aim: To assessed the prognostic significance of pretreatment platelet-to-lymphocyte ratio (PLR) in patients with limited-stage small cell lung cancer (LS-SCLC).

Methods: We retrospectively analyzed 286 patients with LS-SCLC.

Results: Sixty received chemotherapy alone, 158 sequential chemo- and radiotherapy, 38 concurrent chemo- and radiotherapy and 30 surgery combined with therapy. Read More

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/bmm-2018-0415
Publisher Site
http://dx.doi.org/10.2217/bmm-2018-0415DOI Listing
March 2019
12 Reads

Wound exudate CXCL6: a potential biomarker for wound healing of diabetic foot ulcers.

Biomark Med 2019 Feb 3;13(3):167-174. Epub 2019 Jan 3.

Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430021, PR China.

Aim: The aim of this study was to investigate the relationship between CXCL-6 levels in wound exudates and healing of diabetic foot ulcers (DFU).

Materials & Methods: One hundred patients with neuropathic DFU were recruited. Wound exudate CXCL-6 levels were measured by enzyme-linked immunosorbent assay. Read More

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/bmm-2018-0339
Publisher Site
http://dx.doi.org/10.2217/bmm-2018-0339DOI Listing
February 2019
19 Reads

Predictive value of platelet-to-lymphocyte ratio in patients with sarcoidosis.

Biomark Med 2019 Feb 3;13(3):197-204. Epub 2019 Jan 3.

Sağlık Bilimleri University Dr Suat Seren Chest Disease & Surgery Training & Research Hospital, Department of Pulmonology,  Izmir, Turkey.

Aim: We aimed to evaluate platelet-to-lymphocyte ratio (PLR) in patients with sarcoidosis.

Methods: A total of 310 sarcoidosis patients and 220 healthy controls retrospectively were recorded in this study.

Results: PLR was significantly higher in patients with sarcoidosis than in the control group, and was also significantly higher in patients with pulmonary involvement in stage 2-3-4 than in stage 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0252DOI Listing
February 2019
2 Reads

21-gene recurrence score and adjuvant chemotherapy decisions in patients with invasive lobular breast cancer.

Biomark Med 2019 Feb 19;13(2):83-93. Epub 2018 Dec 19.

Department of Radiation Oncology, Xiamen Cancer Hospital, the First Affiliated Hospital of Xiamen University, Xiamen 361003, PR China.

Aim: To determine the effect of the 21-gene recurrence score (RS) on outcome and chemotherapy decision in breast invasive lobular carcinoma (ILC).

Materials & Methods: We included 6467 patients with early stage and estrogen receptor-positive ILC from the Surveillance, epidemiology, and end results database.

Results: A total of 9. Read More

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/bmm-2018-0396
Publisher Site
http://dx.doi.org/10.2217/bmm-2018-0396DOI Listing
February 2019
2 Reads

Elevated serum CCL4/MIP-1β levels in postmenopausal osteoporosis patients are linked with disease severity.

Biomark Med 2019 Jan 18;13(1):17-25. Epub 2018 Dec 18.

The Third Affiliated Hospital of GuangZhou University of Chinese Medicine, GuangZhou, GuangDong Province, 510170, PR China.

Aim: To investigate if the serum CC motif ligand 4 (CCL4) levels are linked to disease severity in patients with postmenopausal osteoporosis (PMOP).

Patients & Methods: We enrolled 66 PMOP females, 68 postmenopausal nonosteoporotic women and 67 healthy women of childbearing age. Bone mineral densities were assessed with dual x-ray absorptiometry scans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0250DOI Listing
January 2019
1 Read

Long noncoding RNA MALAT1 acts as a potential biomarker in cancer diagnosis and detection: a meta-analysis.

Biomark Med 2019 Jan 18;13(1):45-54. Epub 2018 Dec 18.

Department of Urology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, PR China.

Aim: it has been reported that metastasis-associated lung adenocarcinoma transcript 1 is abnormally expressed in various cancers.

Methods: eligible studies fulfilling the search criteria were selected from the online databases. Statistical analysis was performed based on the platforms of STATA 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0128DOI Listing
January 2019
2 Reads

Role of polymorphisms in MMP-9 and TIMP-1 as biomarkers for susceptibility to systemic lupus erythematosus patients.

Biomark Med 2019 Jan 18;13(1):33-43. Epub 2018 Dec 18.

Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, 400012, India.

Aim: To investigate the possible association between MMP-9 (-1562 C/T) and TIMP-1 (372 T/C) polymorphism and inflammatory markers with disease activity in systemic lupus erythematosus (SLE) patients.

Materials & Methods: 150 SLE patients were recruited. Disease severity was assessed by SLEDAI (SLE disease activity index). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0169DOI Listing
January 2019
2 Reads

Welcome to the 13th volume of Biomarkers in Medicine.

Authors:
Ebony Torrington

Biomark Med 2019 Jan 18;13(1):1-3. Epub 2018 Dec 18.

Future Science Group, Unitec House, 2 Albert Place, London N31QB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0418DOI Listing
January 2019
1 Read

Relationship of atherogenic index of plasma and mean platelet volume with ejection fraction in ischemic and nonischemic heart failure.

Biomark Med 2019 Feb 18;13(3):175-183. Epub 2018 Dec 18.

Cardiology Specialist, Cardiology Clinic, Ümraniye Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.

Aim: Our aim was to evaluate the relationship and diagnostic value of atherogenic index of plasma (AIP) and mean platelet volume (MPV) for heart failure (HF) and ejection fraction (EF).

Materials And Methods: In the present study, AIP and MPV were studied in 114 stable HF patients (48 ischemic [42.1%], 66 nonischemic [57. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0196DOI Listing
February 2019
1 Read

A biomarker and therapeutical target in immune thrombocytopenia: TNF receptor-associated factor 6.

Biomark Med 2019 Jan 17;13(1):27-31. Epub 2018 Dec 17.

Department of Hematology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Background: Immune thrombocytopenia (ITP) is an acquired disease characterized by various pathogenetic mechanisms. We aimed to evaluate the value of TRAF6 as a biomarker of pathogenesis in ITP.

Methods:  85 newly diagnosed ITP patients and 85 controls were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0236DOI Listing
January 2019
2 Reads

High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery.

Biomark Med 2018 Dec 6;12(12):1303-1309. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.

Aim: The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown.

Methods: A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point was postoperative hemodynamic instability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0186DOI Listing
December 2018
4 Reads

Levels of 17β-hydroxysteroid dehydrogenase type 10 in CSF are not a valuable biomarker for multiple sclerosis.

Biomark Med 2018 Dec 6;12(12):1331-1340. Epub 2018 Dec 6.

National Institute of Mental Health, 250 67 Klecany, Czech Republic.

Aim: We aimed to characterize the role of mitochondrial 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) overexpression in multiple sclerosis (MS) and to evaluate its use as a biomarker. Materials & methods: We estimated levels of 17β-HSD10, amyloid β 1-42, cyclophilin D, 17β-HSD10-cyclophilin D complexes or 17β-HSD10-parkin complexes in cerebrospinal fluid (CSF) samples.

Results: The increase in 17β-HSD10 levels or in 17β-HSD10-parkin complexes and links to leukocytes were found only in relapsing-remitting MS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0061DOI Listing
December 2018
7 Reads

The usefulness of selected biomarkers in patients with valve disease.

Biomark Med 2018 Dec 6;12(12):1341-1346. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology,  Warsaw, Poland.

Aim: The aim of the study was to investigate the prognostic value of selected biomarkers in patients undergoing valve surgery.

Materials & Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant valve defects that underwent elective valve repair or replacement surgery. The primary end point was any major adverse event including death within 30 days. Read More

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/bmm-2018-0101
Publisher Site
http://dx.doi.org/10.2217/bmm-2018-0101DOI Listing
December 2018
18 Reads

Expression profile of miRNAs in urine samples of bladder cancer patients.

Biomark Med 2018 Dec 3;12(12):1311-1321. Epub 2018 Dec 3.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: miRNAs have been suggested as biomarkers for bladder cancer. We aimed to find a diagnostic panel of miRNAs based on differential expression of miRNAs in urine specimens of patient with bladder cancer compared with control group.

Methods: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm-2018-0190DOI Listing
December 2018
3 Reads