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    1148 results match your criteria Biomarkers in Medicine [Journal]

    1 OF 23

    Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study.
    Biomark Med 2018 Jun 15. Epub 2018 Jun 15.
    Urology Section, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA.
    Aim: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP).

    Methods: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. Read More

    Update on biomarkers for amyloid pathology in Alzheimer's disease.
    Biomark Med 2018 Jun 15. Epub 2018 Jun 15.
    Department of Psychiatry & Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
    At the center of Alzheimer's disease pathogenesis is the aberrant aggregation of amyloid-β (Aβ) into oligomers, fibrils and plaques. Effective monitoring of Aβ deposition directly in patients is essential to assist anti-Aβ therapeutics in target engagement and participant selection. In the advent of approved anti-Aβ therapeutics, biomarkers will become of fundamental importance in initiating treatments having disease modifying effects at the earliest stage. Read More

    Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker.
    Biomark Med 2018 Jun 15. Epub 2018 Jun 15.
    Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
    Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcome, and lacks targeted therapy. Recent studies suggest that cancer stem cells play an important role in tumorigenesis and tumor biology of TNBC. Both CD44/CD24 and ALDH1 breast cancer stem cells are enriched in TNBC and may contribute to the propensity of TNBC for chemotherapy resistance and tumor metastasis. Read More

    Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure.
    Biomark Med 2018 Jun 14. Epub 2018 Jun 14.
    Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, PR China.
    Aim: To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis.

    Methods: Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis. Read More

    A review of biomarkers of Alzheimer's disease in noninvasive samples.
    Biomark Med 2018 Jun 13. Epub 2018 Jun 13.
    Laboratory of Methods, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul, 91.501-970, Porto Alegre, RS, Brazil.
    The discovery of biomarkers that confer high confidence of presymptomatic Alzheimer's disease (AD) diagnosis would be a valuable tool to study the etiology of the disease, to find risk factors, to discover more treatments and medicines. The present work reviews the potential biomarkers of AD based on the concentration changes of small molecules and chemical elements in noninvasive samples (urine, saliva, hair and others). An updated table with 74 target compounds is produced and ranked. Read More

    Circulating miRNAs in blood and urine as diagnostic and prognostic biomarkers for bladder cancer: an update in 2017.
    Biomark Med 2018 Jun 13. Epub 2018 Jun 13.
    Berlin Institute for Urologic Research, 10117 Berlin, Germany.
    This study presents a critical appraisal of previously published study data of miRNAs in blood, urine and exosomes as biomarkers of bladder cancer (BC). The evaluation included 39 articles published from the beginning of 2010 until September 2017 and searched in PubMed. The heterogeneity of studies, due to their clinicopathological variability, including insufficient consideration of diagnostic and prognostic biomarker guidelines and missing internal and external validation of data, do not currently allow the recommending of a useful miRNA marker as diagnostic or prognostic tool in BC. Read More

    Diagnostic and prognostic role of semantic processing in preclinical Alzheimer's disease.
    Biomark Med 2018 Jun 13. Epub 2018 Jun 13.
    Institute of Neurology, Università Cattolica del Sacro Cuore, Rome; Memory Clinic, Fondazione Policlinico Universitario 'A Gemelli', Rome, Italy.
    Relatively spared during most of the timeline of normal aging, semantic memory shows a subtle yet measurable decline even during the pre-clinical stage of Alzheimer's disease. This decline is thought to reflect early neurofibrillary changes and impairment is detectable using tests of language relying on lexical-semantic abilities. A promising approach is the characterization of semantic parameters such as typicality and age of acquisition of words, and propositional density from verbal output. Read More

    Avoid using spectrophotometric determination of malondialdehyde as a biomarker of oxidative stress.
    Biomark Med 2018 Jun 6. Epub 2018 Jun 6.
    Pharmaceutical Analysis Research Center & Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
    Despite wide applications of malondialdehyde as a biomarker of oxidative stress, it possesses a number of characteristics that are against its role as a biomarker. This short communication summarizes these shortcomings and reports some recommendations. Read More

    Blood group 'A' may have a possible modifier effect on familial Mediterranean fever and blood group '0' may be associated with colchicine resistance.
    Biomark Med 2018 Jun 6. Epub 2018 Jun 6.
    Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
    Aim/purpose: Our aim was to investigate the association between blood groups and colchicine resistance in familial Mediterranean fever (FMF) patients.

    Methods: This is a single-center, cross-sectional study. Between January and December 2016, 385 FMF patients were assessed by the Adult and Pediatric Rheumatology outpatient clinics and 297 patients had blood groups (ABO and Rh) results. Read More

    The validity, stability, and utility of measuring uric acid in saliva.
    Biomark Med 2018 Jun 6. Epub 2018 Jun 6.
    Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA 92697, USA.
    Aim: Serum uric acid (UA) is associated with many health conditions, including kidney, cardiovascular, and metabolic disorders. We examined the validity and stability of salivary UA as a noninvasive measure of serum UA.

    Materials & Methods: Using serum and salivary UA data from healthy adults (n = 99), we examined the UA serum-saliva correlation, and UA associations with adiponectin and C-reactive protein. Read More

    Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus.
    Biomark Med 2018 Jun 6. Epub 2018 Jun 6.
    Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
    Aim: The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15. Read More

    Plasma prolidase levels as a biomarker for polycystic ovary syndrome.
    Biomark Med 2018 Jun 6. Epub 2018 Jun 6.
    Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak 124001, India.
    Aim: Assessment of plasma prolidase levels in polycystic ovary syndrome (PCOS).

    Patients & Methods: PCOS patients were screened according to Rotterdam Criterion and prolidase levels were measured.

    Results:  A total of 170 patients and 160 controls were recruited for the study and it was found that prolidase levels were significantly higher in PCOS group (991. Read More

    Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis.
    Biomark Med 2018 Jun 5. Epub 2018 Jun 5.
    Department of Biomedical Sciences - University of Sassari, Sassari, Italy.
    Aim: The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals.

    Methods: Fourteen studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls.

    Results: Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2. Read More

    Models including serum CA-125, BMI, cyst pathology, dysmenorrhea or dyspareunia for diagnosis of endometriosis.
    Biomark Med 2018 Jun 5. Epub 2018 Jun 5.
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.
    Aim: To evaluate preoperative levels of CA-125 and HE4 in patients with endometriosis-like symptoms and to construct diagnostic models.

    Patients: Prospective case-control study included 124 endometriosis patients and 97 control patients.

    Materials & Methods: Logistic regression was used to construct diagnostic models based on serum biomarker levels and clinical data. Read More

    Non-natriuretic peptide biomarkers in heart failure with preserved and reduced ejection fraction.
    Biomark Med 2018 Jun 5. Epub 2018 Jun 5.
    Department of Cardiology, 'Hippokration' Hospital, University of Athens Medical School, Athens, 11528, Greece.
    Heart failure (HF) with reduced and preserved ejection fraction constitutes two entities with distinct pathogenetic backgrounds sharing common features. Beyond natriuretic peptides, several novel biomarkers have been proven useful in the diagnosis, prognosis and treatment of HF. Biomarkers of myocardial fibrosis have a low diagnostic yield in subjects with acute HF but may add prognostic information, especially in patients with HF and preserved ejection fraction. Read More

    Albumin-to-globulin ratio as an independent predictor of mortality in chronic heart failure.
    Biomark Med 2018 Jun 5. Epub 2018 Jun 5.
    3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Disease, Zabrze, Poland.
    Aim: Albumin-to-globulin ratio (AGR) is emerged as a marker of impaired prognosis. We determined the predictive value of AGR in patients with heart failure with reduced ejection fraction (HFrEF).

    Methodology: 999 patients with HFrEF were enrolled. Read More

    BDNF and Tau as biomarkers of severity in multiple sclerosis.
    Biomark Med 2018 Jun 5. Epub 2018 Jun 5.
    Unidad de Investigacion en Enfermedades Neurologicas, Hospital de Especialidades, Centro Medico Nacional SXXI, IMSS, Mexico.
    Aim: Determine if serum levels of tau and BDNF can be used as severity biomarkers in multiple sclerosis (MS).

    Patients & Methods: Subjects with MS, older than 18 and younger than 55 years old were included; 74 patients with a diagnosis of relapsing-remitting MS, 11 with secondary-progressive MS, and 88 controls were included. Total tau and BDNF were measured by Western blot. Read More

    Delta-like 1 protein, vitamin D binding protein and fetuin for detection of Mycobacterium tuberculosis meningitis.
    Biomark Med 2018 Jun 1. Epub 2018 Jun 1.
    Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
    Aim: Tuberculosis meningitis (TBM) diagnosis is difficult, new biomarkers are needed. We evaluated the diagnostic utility of delta-like 1 protein (DLL1), vitamin D binding protein (VDBP) and fetuin.

    Methods: Biomarker concentrations were measured by ELISA in cryopreserved cerebrospinal fluid from 139 HIV-infected Ugandans with suspected meningitis. Read More

    Clinical significance of detecting HLA-DR, 14-3-3η protein and d-dimer in the diagnosis of rheumatoid arthritis.
    Biomark Med 2018 Jun 1. Epub 2018 Jun 1.
    Jiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi 330006, PR China.
    Aim: To investigate the clinical significance of detecting several biomarkers collectively in the diagnosis of rheumatoid arthritis (RA).

    Methods: 128 RA patients, 174 non-RA patients and 80 healthy controls were enrolled. HLA-DR4 and HLA-DR53 were detected by the PCR-SSP method, 14-3-3η protein, anti-CCP and anti-Sa were detected by ELISA and DD was detected by latex immunoturbidimetric assay. Read More

    Expression and phosphorylation of Stathmin 1 indicate poor survival in head and neck squamous cell carcinoma and associate with immune suppression.
    Biomark Med 2018 May 30. Epub 2018 May 30.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, PR China.
    Aim: Immunohistochemistry was used to detect the expression of Stathmin 1 and Serine 38 phospho-Stathmin 1 (p-Stathmin 1) in head and neck squamous cell carcinoma (HNSCC) and research its correlation with clinical parameters, survival and expression of immune checkpoint molecules.

    Results: Stathmin 1 and p-Stathmin 1 overexpression in primary HNSCC is associated with poor overall survival. Stathmin 1 expression is related to tumor size, category and lymph node status. Read More

    A peripheral blood transcriptome biomarker test to diagnose functional recovery potential in advanced heart failure.
    Biomark Med 2018 May 8. Epub 2018 May 8.
    Professor of Medicine Advanced Heart Failure/Mechanical Support/Heart Transplant, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 100 Medical Plaza Drive, Suite 630, Los Angeles, CA 90095, USA.
    Heart failure (HF) is a complex clinical syndrome that causes systemic hypoperfusion and failure to meet the body's metabolic demands. In an attempt to compensate, chronic upregulation of the sympathetic nervous system and renin-angiotensin-aldosterone leads to further myocardial injury, HF progression and reduced O delivery. This triggers progressive organ dysfunction, immune system activation and profound metabolic derangements, creating a milieu similar to other chronic systemic diseases and presenting as advanced HF with severely limited prognosis. Read More

    Plasma and cerebrospinal fluid levels of cytokines as disease markers of neurologic manifestation in long-term HTLV-1 infected individuals.
    Biomark Med 2018 May 8;12(5):447-454. Epub 2018 May 8.
    Laboratório de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Av Alfredo Balena, 190. Belo Horizonte-MG, CEP 30130-100, Brazil.
    Aim: The aim of this study is to evaluate the presence of a particular immunological profile in individuals long-term infected with HTLV-1, followed presenting different clinical courses.

    Materials & Methods: Forty-eight individuals were evaluated for 19 cytokines analyzed in cerebrospinal fluid and plasma of patients with HTLV-1 presenting with and without neurological symptoms.

    Results: Proinflammatory cytokines and the chemokine ligand 11 (ITAC/CXCL11) were increased in individuals with HTLV-1 coursing with neurological symptoms. Read More

    Blood-based novel biomarkers for nonalcoholic steatohepatitis.
    Biomark Med 2018 May 1;12(5):501-515. Epub 2018 May 1.
    Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong 510080, PR China.
    Nonalcoholic fatty liver disease has become a social health challenge of global concern. The term nonalcoholic steatohepatitis (NASH) is a more severe condition than simple steatosis and distinguishing NASH from nonalcoholic fatty liver disease is particularly important. Liver biopsy remains a gold standard in diagnosing NASH. Read More

    Gender specificity improves the early-stage detection of clear cell renal cell carcinoma based on methylomic biomarkers.
    Biomark Med 2018 Apr 30. Epub 2018 Apr 30.
    College of Computer Science & Technology, Key Laboratory of Symbolic Computation & Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin 130012, China.
    Aim: The two genders are different ranging from the molecular to the phenotypic levels. But most studies did not use this important information. We hypothesize that the integration of gender information may improve the overall prediction accuracy. Read More

    Antigens to detect the acute phase of toxoplasmosis in pregnant women: standardized comparison.
    Biomark Med 2018 May 26;12(5):517-534. Epub 2018 Apr 26.
    Departamento de Neurología pediátrica, Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina.
    A key element in any diagnostic technique is the antigen (Ag), a biomarker, but this is usually a protein that has a function to the parasite. Some biological aspects of the Ags and of the Toxoplasma gondii can influence the effectiveness of the diagnosis, as well as the antibody isotype and the characteristics of the assay. A large number of papers have assessed different proteins to distinguish the phases of infection, but the 'indices of effectiveness' differ among reports. Read More

    Urinary biomarkers reporting weakness and validation failure in Type 2 diabetic nephropathy: systematic review.
    Biomark Med 2018 May 26;12(5):487-499. Epub 2018 Apr 26.
    Department of Biochemistry, Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia.
    For better identification of novel diagnostic urinary biomarker in Type 2 diabetic nephropathy (T2DN), methodological and reporting quality is as important as validity of biomarkers. The aim of this systematic review is to find out the best-reported diagnostic urinary biomarkers study in T2DN based on STARD criteria. We also analyzed the validity of urinary markers in the selected articles those followed STARD criteria. Read More

    Impact of pathological features of brain metastases in prognosis.
    Biomark Med 2018 May 26;12(5):475-485. Epub 2018 Apr 26.
    Department of Neurosurgery, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
    Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score.

    Patients & Methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated.

    Results: Most frequent TIL pattern was perivascular (67. Read More

    Role of PARK7 and NDKA in stroke management: a review of PARK7 and NDKA as stroke biomarkers.
    Biomark Med 2018 May 26;12(5):419-425. Epub 2018 Apr 26.
    Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 11004, PR China.
    Aim: Biomarkers are molecules measured in plasma, serum or other body fluids to characterize a disease. PARK7 and NDKA roles in the management of stroke are still on study. Therefore, their potentials need to be developed in totality. Read More

    Urinary transcriptomics reveals patterns associated with subclinical injury of the renal allograft.
    Biomark Med 2018 May 26;12(5):427-438. Epub 2018 Apr 26.
    Sorbonne Universités, UPMC Univ Paris 06, UMR_S1155, Paris, France.
    Aim: Subclinical pathological features in renal allograft biopsies predict poor outcomes, and noninvasive biomarkers are wanted. RNA quantification in urine predicts overt rejection. We hypothesized that a whole transcriptome analysis would be informative, even for discrete injury. Read More

    The increase in copeptin levels in mild head trauma does not predict the severity and the outcome of brain damage.
    Biomark Med 2018 04 5. Epub 2018 Apr 5.
    Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli, 17. 28100 - Novara, Italy.
    Aim: To investigate the copeptin prognostic role in mild head trauma.

    Methods: We enrolled 105 adult patients who entered the emergency room because of recent mild head trauma; we evaluated: clinical picture, imaging and laboratory data (including copeptin).

    Results: Copeptin resulted higher in mild head trauma patients compared with controls: 29. Read More

    BP1, a potential biomarker for breast cancer prognosis.
    Biomark Med 2018 May 26;12(5):535-545. Epub 2018 Mar 26.
    Department of Biochemistry & Molecular Medicine, George Washington University, Washington, DC 20037, USA.
    Homeobox genes are critical in tumor development. An isoform protein of DLX4 called BP1 is expressed in 80% of invasive ductal breast carcinomas. BP1 overexpression is implicated in an aggressive phenotype and poor prognosis. Read More

    TK1 overexpression is associated with the poor outcomes of lung cancer patients: a systematic review and meta-analysis.
    Biomark Med 2018 Apr 26;12(4):403-413. Epub 2018 Mar 26.
    Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Traditional Chinese Medical University, Nanning 530023, PR China.
    Aim: The study aimed to unveil the effect of TK1 expression on the clinicopathological significance and prognosis in patients with lung cancer. Results & methodology: Studies for meta-analysis were selected according to a thorough literature search in databases (PubMed, EMBASE and Chinese databases). Ten studies containing 1393 lung cancer patients were investigated in our analysis. Read More

    Serum matrix metalloproteinase-9 level as a biomarker for colorectal cancer: a diagnostic meta-analysis.
    Biomark Med 2018 Apr 26;12(4):393-402. Epub 2018 Mar 26.
    Luohe Medical College, Luohe 462002, Henan Province, PR China.
    Aim: To comprehensively evaluate the diagnostic value of serum matrix metalloproteinase-9 (MMP-9) level for colorectal cancer (CRC).

    Methods: Both of the relationships between MMP-9 level and CRC and the diagnostic value were evaluated from 12 eligible papers.

    Results: The high MMP-9 level increased CRC risk. Read More

    Association of monocyte to high-density lipoprotein cholesterol ratio with carotid artery intima-media thickness in patients with systemic lupus erythematosus.
    Biomark Med 2018 Apr 23;12(4):359-364. Epub 2018 Mar 23.
    State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, PR China.
    Aim: The purpose of this study was to evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and carotid atherosclerostic plaque in patients with systemic lupus erythematosus (SLE).

    Methods: A total of 214 SLE patients were divided into two groups according to the results of ultrasonic examination: carotid arterial atherosclerotic plaque groups and noncarotid arterial atherosclerosis groups.

    Results: The values of monocyte to high-density lipoprotein-cholesterol ratio (MHR) increase in carotid arterial atherosclerotic plaque groups compared with noncarotid arterial atherosclerosis groups (0. Read More

    Relationship between uric acid levels and cardiometabolic findings in a large cohort of β-thalassemia major patients.
    Biomark Med 2018 Apr 23;12(4):341-348. Epub 2018 Mar 23.
    MRI Unit, Fondazione CNR-Regione Toscana G Monasterio, Pisa, Italy.
    Aim: to evaluate the relationship between uric acid (UA), hepatic and cardiac iron overload (T2*-MRI), ferritin, endocrinological diseases and cardiac complications in a large thalassemia major (TM) cohort.

    Methods:  A total of 369 TM patients (187 men; 33 ± 6 years) were retrospectively studied, from the myocardial iron overload in thalassemia (MIOT) electronic databank.

    Results: Multiple regression model identified male sex (p < 0. Read More

    Vitamin D levels are associated with epistaxis severity and bleeding duration in hereditary hemorrhagic telangiectasia.
    Biomark Med 2018 Apr 14;12(4):365-371. Epub 2018 Mar 14.
    Divisions of Cardiovascular Medicine and Pediatric Cardiology, University of Utah, Salt Lake City, UT 84132, USA.
    Aim: To explore the association between vitamin D levels and mild versus severe epistaxis, as well as the overall epistaxis severity score (ESS) in patients with hereditary hemorrhagic telangiectasia.

    Patients & Methods: A retrospective chart review of 198 patients was performed to explore the relationship between vitamin D levels and the ESS. Vitamin D levels were also compared with those with mild epistaxis to those with severe epistaxis. Read More

    Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene.
    Biomark Med 2018 May 14;12(5):439-446. Epub 2018 Mar 14.
    Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
    Aim: The aim of the study was to explore the parent-of-origin effects (POEs) on a range of human nuclear magnetic resonance metabolites.

    Materials & Methods: We search for POEs in 14,815 unrelated individuals from Estonian and Finnish cohorts using POE method for the genotype data imputed with 1000 G reference panel and 82 nuclear magnetic resonance metabolites.

    Results: Meta-analysis revealed the evidence of POE for the variant rs1412727 in PTPRD gene for the metabolite: triglycerides in medium very low-density lipoprotein. Read More

    Index of cardiac electrophysiological balance and transmural dispersion of the repolarization index relationships with pericardial fat volume and coronary calcification.
    Biomark Med 2018 Apr 8;12(4):321-328. Epub 2018 Mar 8.
    Radiology Department, Medicine College, Kufa University, Najaf, Iraq.
    Aim: To assess the possible relationship between coronary atherosclerosis markers, pericardial fat volume (PFV) and coronary artery calcification, with ECG markers of index of the cardiac electrophysiological balance (iCEB) and transmural dispersion of the repolarization in patients with suspected coronary artery disease.

    Methodology: One hundred patients who underwent 64-slice multidetector computed tomography angiography were found to be eligible and were enrolled in the study.

    Results: Patients with high iCEB levels tended to have a higher PFV values compared with patients with low iCEB levels (median [interquartile range]) (152 [29-206] vs 96 [14-177]; p = 0. Read More

    Association of serum procalcitonin level with in-stent restenosis in patients undergoing bare-metal stent implantation.
    Biomark Med 2018 May 8;12(5):455-463. Epub 2018 Mar 8.
    Department of Cardiology, Ankara Numune Education & Research Hospital, Ankara, Turkey.
    Aim: Procalcitonin (PCT) is an inflammatory marker and elevated PCT levels are associated with cardiovascular events. We assessed whether PCT level is an independent predictor of bare-metal stent (BMS) in-stent restenosis (ISR).

    Patients & Methods: We evaluated 240 patients undergoing BMS implantation. Read More

    The search for noninvasive methods to identify liver fibrosis in children with nonalcoholic fatty liver disease.
    Biomark Med 2018 Mar 8;12(3):265-273. Epub 2018 Mar 8.
    Texas Liver Institute, UT Health San Antonio, San Antonio, TX 78215, USA.
    Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity epidemic. Recent studies have clearly shown that the stage of fibrosis in adults with NAFLD is the most important histological feature in long-term outcomes and the development of liver-related complications. Despite the paucity of data regarding the natural history of pediatric NAFLD, its progression to cirrhosis and end-stage liver disease requiring liver transplantation is well documented. Read More

    Increased kynurenine plasma concentrations and kynurenine-tryptophan ratio in mild-to-moderate chronic obstructive pulmonary disease patients.
    Biomark Med 2018 Mar 6;12(3):229-237. Epub 2018 Mar 6.
    Department of Clinical & Experimental Medicine, University of Sassari, Sassari, Italy.
    Aim: Since an increase in kynurenine (Kyn) plasma concentrations has been proposed as marker of immune system activation, we studied the associations between the Kyn levels and presence and severity of chronic obstructive pulmonary disease (COPD).

    Methods & Results: Plasma Kyn, tryptophan (Trp) and Kyn/Trp ratio were measured in 43 COPD patients with clinically defined mild (n = 29) or moderate (n = 14) disease and 43 age- and sex-matched healthy controls. When compared with controls, COPD patients had significantly higher plasma Kyn concentrations and Kyn/Trp ratios. Read More

    Vitamin D-binding protein and its polymorphisms as a predictor for metabolic syndrome.
    Biomark Med 2018 May 5;12(5):465-473. Epub 2018 Mar 5.
    Department of Tropical Nutrition & Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
    Aim: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population.

    Materials & Methods: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays. Read More

    Vitamin D serum levels and receptor genetic polymorphisms are associated with hepatitis B virus and HIV infections and IFN-λ levels.
    Biomark Med 2017 Sep 15;11(9):733-740. Epub 2017 Sep 15.
    Center of Interventional Oncology & Liver Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
    Aim: Vitamin D is involved in antiviral/antitumor activities. Its associations to hepatitis B virus (HBV), HIV and hepatocellular carcinoma (HCC) are unclear.

    Materials & Methods: A retrospective study was conducted on 232 chronic hepatitis B (CHB) patients and 72 HIV-infected patients. Read More

    Biomarkers for Sjögren's syndrome.
    Biomark Med 2018 Mar 20;12(3):275-286. Epub 2018 Feb 20.
    Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Pisa, 56126, Italy.
    Sjögren's syndrome (pSS) is a complex and heterogeneous disorder characterized by different clinical subsets. Recently, great efforts have been made searching for reliable biomarkers able to ameliorate the diagnostic algorithm and the prognostic stratification of pSS patients and ultimately allowing the scientific community to address some of the unmet needs for the disease. In this review, we have summarized the state of the art of 'traditional' widely acknowledged clinical, serological and histologic biomarkers for pSS with the aim of highlighting their relevance and limitations in clinical practice. Read More

    Sex hormone-binding globulin levels during the first trimester may predict gestational diabetes mellitus development.
    Biomark Med 2018 Mar 20;12(3):239-244. Epub 2018 Feb 20.
    Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.
    Aim: To investigate the association of sex hormone-binding globulin (SHBG) levels of early pregnancy with gestational diabetes mellitus (GDM) development.

    Methods: A total of 443 pregnant women during the first trimester (<12 weeks) were enrolled. SHBG levels were measured. Read More

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