1,235 results match your criteria Biomarkers in Medicine [Journal]


Forms of diagnostic material as sources of miRNA biomarkers in hepatocellular carcinoma: a preliminary study.

Biomark Med 2019 Mar 11. Epub 2019 Mar 11.

Department of Medical Biochemistry, Medical University of Lodz, Mazowiecka Street 6/8 92-215 Lodz, Poland.

Aim: To assess the diagnostic value of selected miRNAs from various material collected from hepatocellular carcinoma (HCC) patients.

Patients & Methods: Tissue, serum, urine and fecal samples from HCC patients and healthy individuals were screened for associated miRNAs using microarray analysis; the selected miRNAs were then validated by real time-quantitative PCR on 65 patients.

Results: Serum miR-122, a combination of serum miR-155 with miR-885-5p, a combination of urinary miR-532-3p with miR-765, and fecal miR-320a displayed 100% efficiency in discriminating patients from controls. Read More

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http://dx.doi.org/10.2217/bmm-2018-0485DOI Listing

Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery.

Biomark Med 2019 Feb 27. Epub 2019 Feb 27.

Vascular Biology, Cardiovascular Sciences, National Heart & Lung Institute Division, Faculty of Medicine, Imperial College London, London, SW3 6LY, UK.

Aim: We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB).

Patients & Methods: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB.

Results: All markers increased significantly post-CPB with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI within 7 days. Read More

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http://dx.doi.org/10.2217/bmm-2018-0238DOI Listing
February 2019

Clinicopathological and prognostic significance of octamer-binding transcription factor 4 in patients with gastric cancer: a systematic review and meta-analysis.

Biomark Med 2019 Feb 27. Epub 2019 Feb 27.

The First Hospital of Qiqihaer City, Qiqihaer, Heilongjiang, 161005, PR China.

Aim: The role of octamer-binding transcription factor 4 (Oct4) in gastric cancer (GC) progression is still under debate and reported results are inconsistent. Therefore, we conducted a meta-analysis to evaluate the clinicopathological and prognostic significance of Oct4 expression in patients with GC.

Materials & Methods: Relevant articles were retrieved from a diverse number of databases, and meta-analysis was completed using STATA software 12. Read More

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http://dx.doi.org/10.2217/bmm-2018-0086DOI Listing
February 2019

Galectin-3 is associated with arterial stiffness among hemodialysis patients.

Biomark Med 2019 Feb 27. Epub 2019 Feb 27.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, PR China.

Aim: To evaluate the association between galectin-3 and arterial stiffness among hemodialysis patients.

Methods: We enrolled 311 patients (median age: 61 years) with a median hemodialysis time of 90 months and a mean galectin-3 concentration of 29.78 ng/ml. Read More

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http://dx.doi.org/10.2217/bmm-2018-0488DOI Listing
February 2019
2.858 Impact Factor

Analysis of long noncoding RNAs for acute rejection and graft outcome in kidney transplant biopsies.

Biomark Med 2019 Feb 26. Epub 2019 Feb 26.

Information & network center, Central South University, Changsha, 410083, PR China.

Aim: To analyse long noncoding RNAs (lncRNA) in kidney transplant biopsies.

Methods: Using a data mining approach, we constructed expression profiles in kidney transplant cohorts (n = 1105) from Gene Expression Omnibus. Integrative analysis of the lncRNAs with acute rejection (AR), T-cell-mediated acute rejection (TCMR) and graft loss were performed. Read More

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http://dx.doi.org/10.2217/bmm-2018-0272DOI Listing
February 2019
2.858 Impact Factor

Circulating biomarkers for high-grade glioma.

Biomark Med 2019 Feb 26. Epub 2019 Feb 26.

Radiation Oncology Branch, National Cancer Institute, 9000 Rockville Pike, Building 10 B3B55, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2217/bmm-2018-0463DOI Listing
February 2019
1 Read

Potential biomarkers for antidiastole of tuberculous and malignant pleural effusion by proteome analysis.

Biomark Med 2019 Feb 22;13(2):123-133. Epub 2019 Feb 22.

Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.

Aim: To investigate novel potential biomarkers for antidiastole of tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE).

Materials & Methods: iTRAQTM-coupled LC-MS/MS were applied to analyze the proteome of TPE and MPE samples. The candidate proteins were verified by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.2217/bmm-2018-0200DOI Listing
February 2019
1 Read

Micro-RNA335-5p targeted inhibition of sKlotho and promoted oxidative stress-mediated aging of endothelial cells.

Biomark Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Geriatrics/West China hospital of SCU, Chengdu, China.

Aim: MiR-335-5p expression might induce endothelial cells (ECs) aging and target inhibit sKlotho. This study aimed to investigate whether oxidative stress evoked miR-335-5p expression and whether miR-335-5p-regulated ECs function through sKlotho.

Methods: The expression of miR-335-5p was detected in human umbilical vein endothelial cells treated with HO. Read More

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http://dx.doi.org/10.2217/bmm-2018-0430DOI Listing
February 2019
2.858 Impact Factor

hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.

Biomark Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, The Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, People's Republic of China.

Aim: To assess whether expression of circular RNAs (circRNAs) in peripheral blood mononuclear cells can serve as a biomarker for diagnosis and/or therapeutic response in people living with schizophrenia (SZ).

Materials & Methods: Differentially expressed circRNAs were screened via microarray in nine individuals living with SZ and nine healthy controls, then quantified using real-time quantitative reverse transcription PCR in SZ (n = 102) and healthy control (n = 103) groups. CircRNAs were re-assessed twice in 30 randomly selected individuals living with SZ after 4- and 8-week antipsychotic treatments. Read More

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http://dx.doi.org/10.2217/bmm-2018-0447DOI Listing
February 2019

Pancreatic cancer biomarker detection by two support vector strategies for recursive feature elimination.

Biomark Med 2019 Feb 15;13(2):105-121. Epub 2019 Feb 15.

Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China.

Aim: Pancreatic cancer is one of the worst malignant tumors in prognosis. Therefore, to reduce the mortality rate of pancreatic cancer, early diagnosis and prompt treatment are particularly important.

Results: We put forward a new feature-selection method that was used to find clinical markers for pancreatic cancer by combination of Support Vector Machine Recursive Feature Elimination (SVM-RFE) and Large Margin Distribution Machine Recursive Feature Elimination (LDM-RFE) algorithms. Read More

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http://dx.doi.org/10.2217/bmm-2018-0273DOI Listing
February 2019
1 Read

Elevated SLC6A6 expression drives tumorigenesis and affects clinical outcomes in gastric cancer.

Biomark Med 2019 Feb 15;13(2):95-104. Epub 2019 Feb 15.

Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430000, PR China.

Aim: To assess SLC6A6 expression in gastric cancer, its correlation with patients' clinicopathological features and survival, and the possible epigenetic regulation mechanism.

Methods: Expression profiles and methylation data were obtained from the Gene Expression Omnibus database and the Cancer Genome Atlas. The SLC6A6's protein level were obtained from the Human Protein Atlas. Read More

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http://dx.doi.org/10.2217/bmm-2018-0256DOI Listing
February 2019
1 Read

Preoperative CA125 value predicts Glisson capsule involvement in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

Biomark Med 2019 Feb 13. Epub 2019 Feb 13.

Department of General Surgery, University of Health Sciences Kanuni Sultan Suleyman Training & Research Hospital, Istanbul, Turkey.

Aim: The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis.

Methods: The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19. Read More

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http://dx.doi.org/10.2217/bmm-2019-0009DOI Listing
February 2019
1 Read

N-terminal of the prohormone brain natriuretic peptide is a predictor of hemodynamic instability in valve disease.

Biomark Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.

Aim: The usefulness of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) as a predictor of perioperative hemodynamic instability is not fully elucidated.

Methods: This prospective study was conducted on a group of 455 patients undergoing elective heart valve surgery. The primary end point at the 30-day follow-up was postoperative hemodynamic instability. Read More

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http://dx.doi.org/10.2217/bmm-2019-0002DOI Listing
February 2019
1 Read

The association of estimated whole blood viscosity with hemodynamic parameters and prognosis in patients with heart failure.

Biomark Med 2019 Feb 23;13(2):69-82. Epub 2019 Jan 23.

Cardiology Department, Turkey Yuksek Ihtisas Training & Research Hospital, Ankara, Turkey.

Aim: We aimed to investigate the association of estimated whole blood viscosity (WBV) with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction.

Materials & Methods: Total of 542 patients were included and followed-up for median 13 months.

Results: The WBV parameters had negative relationship with right atrium pressure and positive correlation with cardiac index. Read More

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http://dx.doi.org/10.2217/bmm-2018-0309DOI Listing
February 2019
3 Reads

Measurement of pancreatic stone protein in the identification and management of sepsis.

Biomark Med 2019 Feb 23;13(2):135-145. Epub 2019 Jan 23.

Abionic SA, Route de la Corniche 5, 1066 Epalinges, Switzerland.

Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection resulting in multiple organ dysfunctions. Early diagnosis and management of sepsis is key to improve patient outcome but remains challenging. Despite extensive research, only few biomarkers have so far proven to be helpful in the diagnosis of sepsis. Read More

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http://dx.doi.org/10.2217/bmm-2018-0194DOI Listing
February 2019

Biomarkers for the prediction of cardiac readmission.

Biomark Med 2019 Feb 23;13(2):55-58. Epub 2019 Jan 23.

The Dartmouth Institute for Health Policy & Clinical Practice, Geisel School of Medicine, Lebanon, NH 03756, USA.

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http://dx.doi.org/10.2217/bmm-2018-0381DOI Listing
February 2019

The use of serum zinc to prostate-specific antigen ratio as a biomarker in the prediction of prostate biopsy outcomes.

Biomark Med 2019 Feb 23;13(2):59-68. Epub 2019 Jan 23.

Department of Urology, Bagcilar Training & Research Hospital, Merkez Mah, Dr Sadık Ahmet Cad, Bagcilar/Istanbul, Catalca/Istanbul, Turkey.

Aim: To generate a combination of serum zinc (Zn) and prostate-specific antigen (PSA) in an attempt to provide better prediction of prostate biopsy outcomes with Zn/PSA ratios.

Materials & Methods: Diagnostic performances of PSA and Zn/PSA were investigated using receiver operating characteristic and the area under the curve analysis and McNemar test in 480 men. Decision curve analysis was also used to determine the net clinical benefits of the two parameters. Read More

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http://dx.doi.org/10.2217/bmm-2018-0260DOI Listing
February 2019
1 Read

The intricate role of miR-155 in carcinogenesis: potential implications for esophageal cancer research.

Biomark Med 2019 Feb 23;13(2):147-159. Epub 2019 Jan 23.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

MiRNAs have immerged as essential modulators of key cellular procuresses involved in post-transcriptional regulation of the human transcriptome. They are essential components of complex regulatory networks that modulate most important physiological functions of cells. MicroRNA-155 (miR-155) is a multifaceted regulator of cell proliferation, cell cycle, development, immunity and inflammation that plays pivotal, and sometimes contradictory, roles in numerous cancers including esophageal cancer. Read More

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http://dx.doi.org/10.2217/bmm-2018-0127DOI Listing
February 2019
45 Reads
2.858 Impact Factor

RAB27A is an independent prognostic factor in clear cell renal cell carcinoma.

Biomark Med 2019 Jan 21. Epub 2019 Jan 21.

Gyeongsang National University School of Medicine, Jinju, Korea.

Aim: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC).

Materials & Methods: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated.

Results: The T stage showed a significant correlation with RAB27A intensity (p < 0. Read More

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http://dx.doi.org/10.2217/bmm-2018-0336DOI Listing
January 2019
2 Reads

Mitochondrial DNA deletions accurately detect endometriosis in symptomatic females of child-bearing age.

Biomark Med 2019 Jan 15. Epub 2019 Jan 15.

MDNA Life Sciences UK, The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne, NE4 5BX, UK.

Aim: Accurate noninvasive diagnostic aids for endometriosis are needed. We evaluated mitochondrial DNA deletions as potential biomarkers for endometriosis.

Methods: The diagnostic accuracy of deletions was evaluated by quantitative polymerase chain reaction (QPCR) using well-characterized clinical specimens from all subtypes and stages of endometriosis in a case-control format (n = 182). Read More

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http://dx.doi.org/10.2217/bmm-2018-0419DOI Listing
January 2019
2 Reads

Initial platelet-to-lymphocyte count as prognostic factor in limited-stage small cell lung cancer.

Biomark Med 2019 Jan 9. Epub 2019 Jan 9.

Radiation Oncology Department of Thoracic Cancer, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Liaoning, Shenyang 110042, PR China.

Aim: To assessed the prognostic significance of pretreatment platelet-to-lymphocyte ratio (PLR) in patients with limited-stage small cell lung cancer (LS-SCLC).

Methods: We retrospectively analyzed 286 patients with LS-SCLC.

Results: Sixty received chemotherapy alone, 158 sequential chemo- and radiotherapy, 38 concurrent chemo- and radiotherapy and 30 surgery combined with therapy. Read More

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https://www.futuremedicine.com/doi/10.2217/bmm-2018-0415
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http://dx.doi.org/10.2217/bmm-2018-0415DOI Listing
January 2019
7 Reads

Wound exudate CXCL6: a potential biomarker for wound healing of diabetic foot ulcers.

Biomark Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430021, PR China.

Aim: The aim of this study was to investigate the relationship between CXCL-6 levels in wound exudates and healing of diabetic foot ulcers (DFU).

Materials & Methods: One hundred patients with neuropathic DFU were recruited. Wound exudate CXCL-6 levels were measured by enzyme-linked immunosorbent assay. Read More

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https://www.futuremedicine.com/doi/10.2217/bmm-2018-0339
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http://dx.doi.org/10.2217/bmm-2018-0339DOI Listing
January 2019
13 Reads

Predictive value of platelet-to-lymphocyte ratio in patients with sarcoidosis.

Biomark Med 2019 Jan 3. Epub 2019 Jan 3.

Sağlık Bilimleri University Dr Suat Seren Chest Disease & Surgery Training & Research Hospital, Department of Pulmonology,  Izmir, Turkey.

Aim: We aimed to evaluate platelet-to-lymphocyte ratio (PLR) in patients with sarcoidosis.

Methods: A total of 310 sarcoidosis patients and 220 healthy controls retrospectively were recorded in this study.

Results: PLR was significantly higher in patients with sarcoidosis than in the control group, and was also significantly higher in patients with pulmonary involvement in stage 2-3-4 than in stage 1. Read More

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http://dx.doi.org/10.2217/bmm-2018-0252DOI Listing
January 2019
2 Reads

21-gene recurrence score and adjuvant chemotherapy decisions in patients with invasive lobular breast cancer.

Biomark Med 2019 Feb 19;13(2):83-93. Epub 2018 Dec 19.

Department of Radiation Oncology, Xiamen Cancer Hospital, the First Affiliated Hospital of Xiamen University, Xiamen 361003, PR China.

Aim: To determine the effect of the 21-gene recurrence score (RS) on outcome and chemotherapy decision in breast invasive lobular carcinoma (ILC).

Materials & Methods: We included 6467 patients with early stage and estrogen receptor-positive ILC from the Surveillance, epidemiology, and end results database.

Results: A total of 9. Read More

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https://www.futuremedicine.com/doi/10.2217/bmm-2018-0396
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http://dx.doi.org/10.2217/bmm-2018-0396DOI Listing
February 2019
2 Reads

Elevated serum CCL4/MIP-1β levels in postmenopausal osteoporosis patients are linked with disease severity.

Biomark Med 2019 Jan 18;13(1):17-25. Epub 2018 Dec 18.

The Third Affiliated Hospital of GuangZhou University of Chinese Medicine, GuangZhou, GuangDong Province, 510170, PR China.

Aim: To investigate if the serum CC motif ligand 4 (CCL4) levels are linked to disease severity in patients with postmenopausal osteoporosis (PMOP).

Patients & Methods: We enrolled 66 PMOP females, 68 postmenopausal nonosteoporotic women and 67 healthy women of childbearing age. Bone mineral densities were assessed with dual x-ray absorptiometry scans. Read More

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http://dx.doi.org/10.2217/bmm-2018-0250DOI Listing
January 2019
1 Read

Long noncoding RNA MALAT1 acts as a potential biomarker in cancer diagnosis and detection: a meta-analysis.

Biomark Med 2019 Jan 18;13(1):45-54. Epub 2018 Dec 18.

Department of Urology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, PR China.

Aim: it has been reported that metastasis-associated lung adenocarcinoma transcript 1 is abnormally expressed in various cancers.

Methods: eligible studies fulfilling the search criteria were selected from the online databases. Statistical analysis was performed based on the platforms of STATA 14. Read More

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http://dx.doi.org/10.2217/bmm-2018-0128DOI Listing
January 2019
2 Reads

Role of polymorphisms in MMP-9 and TIMP-1 as biomarkers for susceptibility to systemic lupus erythematosus patients.

Biomark Med 2019 Jan 18;13(1):33-43. Epub 2018 Dec 18.

Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, 400012, India.

Aim: To investigate the possible association between MMP-9 (-1562 C/T) and TIMP-1 (372 T/C) polymorphism and inflammatory markers with disease activity in systemic lupus erythematosus (SLE) patients.

Materials & Methods: 150 SLE patients were recruited. Disease severity was assessed by SLEDAI (SLE disease activity index). Read More

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http://dx.doi.org/10.2217/bmm-2018-0169DOI Listing
January 2019
2 Reads

Welcome to the 13th volume of Biomarkers in Medicine.

Authors:
Ebony Torrington

Biomark Med 2019 Jan 18;13(1):1-3. Epub 2018 Dec 18.

Future Science Group, Unitec House, 2 Albert Place, London N31QB, UK.

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http://dx.doi.org/10.2217/bmm-2018-0418DOI Listing
January 2019
1 Read

Relationship of atherogenic index of plasma and mean platelet volume with ejection fraction in ischemic and nonischemic heart failure.

Biomark Med 2018 Dec 18. Epub 2018 Dec 18.

Cardiology Specialist, Cardiology Clinic, Ümraniye Training & Research Hospital, University of Health Sciences, Istanbul, Turkey.

Aim: Our aim was to evaluate the relationship and diagnostic value of atherogenic index of plasma (AIP) and mean platelet volume (MPV) for heart failure (HF) and ejection fraction (EF).

Materials And Methods: In the present study, AIP and MPV were studied in 114 stable HF patients (48 ischemic [42.1%], 66 nonischemic [57. Read More

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http://dx.doi.org/10.2217/bmm-2018-0196DOI Listing
December 2018
1 Read

A biomarker and therapeutical target in immune thrombocytopenia: TNF receptor-associated factor 6.

Biomark Med 2019 Jan 17;13(1):27-31. Epub 2018 Dec 17.

Department of Hematology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Background: Immune thrombocytopenia (ITP) is an acquired disease characterized by various pathogenetic mechanisms. We aimed to evaluate the value of TRAF6 as a biomarker of pathogenesis in ITP.

Methods:  85 newly diagnosed ITP patients and 85 controls were included. Read More

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http://dx.doi.org/10.2217/bmm-2018-0236DOI Listing
January 2019
2 Reads

High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery.

Biomark Med 2018 Dec 6;12(12):1303-1309. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland.

Aim: The usefulness of high-sensitivity troponin T (hs-TnT) as a predictor of perioperative hemodynamic instability is currently unknown.

Methods: A prospective study was conducted on a group of 708 consecutive patients with significant valvular heart disease that underwent elective valve surgery. The primary end point was postoperative hemodynamic instability. Read More

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http://dx.doi.org/10.2217/bmm-2018-0186DOI Listing
December 2018
4 Reads

Levels of 17β-hydroxysteroid dehydrogenase type 10 in CSF are not a valuable biomarker for multiple sclerosis.

Biomark Med 2018 Dec 6;12(12):1331-1340. Epub 2018 Dec 6.

National Institute of Mental Health, 250 67 Klecany, Czech Republic.

Aim: We aimed to characterize the role of mitochondrial 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) overexpression in multiple sclerosis (MS) and to evaluate its use as a biomarker. Materials & methods: We estimated levels of 17β-HSD10, amyloid β 1-42, cyclophilin D, 17β-HSD10-cyclophilin D complexes or 17β-HSD10-parkin complexes in cerebrospinal fluid (CSF) samples.

Results: The increase in 17β-HSD10 levels or in 17β-HSD10-parkin complexes and links to leukocytes were found only in relapsing-remitting MS. Read More

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http://dx.doi.org/10.2217/bmm-2018-0061DOI Listing
December 2018
2 Reads

The usefulness of selected biomarkers in patients with valve disease.

Biomark Med 2018 Dec 6;12(12):1341-1346. Epub 2018 Dec 6.

Department of Acquired Cardiac Defects, Institute of Cardiology,  Warsaw, Poland.

Aim: The aim of the study was to investigate the prognostic value of selected biomarkers in patients undergoing valve surgery.

Materials & Methods: A prospective study was conducted on a group of consecutive patients with hemodynamically significant valve defects that underwent elective valve repair or replacement surgery. The primary end point was any major adverse event including death within 30 days. Read More

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https://www.futuremedicine.com/doi/10.2217/bmm-2018-0101
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http://dx.doi.org/10.2217/bmm-2018-0101DOI Listing
December 2018
15 Reads

Expression profile of miRNAs in urine samples of bladder cancer patients.

Biomark Med 2018 Dec 3;12(12):1311-1321. Epub 2018 Dec 3.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: miRNAs have been suggested as biomarkers for bladder cancer. We aimed to find a diagnostic panel of miRNAs based on differential expression of miRNAs in urine specimens of patient with bladder cancer compared with control group.

Methods: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. Read More

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http://dx.doi.org/10.2217/bmm-2018-0190DOI Listing
December 2018
3 Reads

Discovering biomarkers in bladder cancer by metabolomics.

Biomark Med 2018 Dec 3;12(12):1347-1359. Epub 2018 Dec 3.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, PR China.

It has become increasingly clear that the development of cancer, a multifactorial disease, cannot be explained by a single molecule or gene mutation. As a new discipline, metabolomics focuses on the body's metabolite changes, and attempts to find differences to explain the development of cancer; it has proven to be effective and credible. Metabolic studies of bladder cancer (BCa) lag behind those of other tumors. Read More

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http://dx.doi.org/10.2217/bmm-2018-0229DOI Listing
December 2018
3 Reads

Increased circulating interleukin-8 levels in systemic lupus erythematosus patients: a meta-analysis.

Biomark Med 2018 Nov 4;12(11):1291-1302. Epub 2018 Dec 4.

Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, PR China.

Aim: We performed this meta-analysis in order to evaluate circulating interleukin-8 (IL-8) levels in systemic lupus erythematosus (SLE) patients more accurately and explore its related influencing factors.

Methods: The related literature was systematically searched in PubMed, Embase and The Cochrane Library database (up to 28 March 2018). All data analysis was performed by Stata 12. Read More

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http://dx.doi.org/10.2217/bmm-2018-0217DOI Listing
November 2018
11 Reads

The association among biomarkers of renal and heart function in patients with heart failure: the role of NGAL.

Biomark Med 2018 Dec 4;12(12):1323-1330. Epub 2018 Dec 4.

First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens Medical School, Athens, Greece.

Aim: The NGAL is a biomarker of renal injury associated with the progression of heart failure (HF). We examine the association of NGAL with galectin-3 in patients with chronic HF.

Methods: We consecutively enrolled 115 subjects with stable ischemic HF of reduced ejection fraction. Read More

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http://dx.doi.org/10.2217/bmm-2018-0100DOI Listing
December 2018
1 Read

Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia.

Biomark Med 2018 Nov 30;12(11):1251-1259. Epub 2018 Nov 30.

Department of Emergency Medicine, Odense University Hospital, Kløvervænget 25, entrance 63-65, 5000 Odense C, Denmark.

Aim: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.

Patients & Methods: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Read More

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http://dx.doi.org/10.2217/bmm-2018-0043DOI Listing
November 2018
1 Read

Cardiac MRI biomarkers for Duchenne muscular dystrophy.

Biomark Med 2018 Nov 30;12(11):1271-1289. Epub 2018 Nov 30.

Department of Radiological Sciences, University of California, Los Angeles, CA 90024, USA.

Duchenne muscular dystrophy (DMD) is a fatal inherited genetic disorder that results in progressive muscle weakness and ultimately loss of ambulation, respiratory failure and heart failure. Cardiac MRI (MRI) plays an increasingly important role in the diagnosis and clinical care of boys with DMD and associated cardiomyopathies. Conventional cardiac MRI biomarkers permit measurements of global cardiac function and presence of fibrosis, but changes in these measures are late manifestations. Read More

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http://dx.doi.org/10.2217/bmm-2018-0125DOI Listing
November 2018
13 Reads

Circulating bone-specific alkaline phosphatase and abdominal aortic calcification in maintenance hemodialysis patients.

Biomark Med 2018 Nov 30;12(11):1231-1239. Epub 2018 Nov 30.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.

Aim: To explore the relationship between circulating bone-specific alkaline phosphatase (BALP) levels and abdominal aortic calcification (AAC) in patients receiving maintenance hemodialysis (MHD).

Methods: A total of 156 MHD patients were enrolled. Serum BALP levels were measured using ELISA, and AAC was assessed via lateral abdominal radiography. Read More

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http://dx.doi.org/10.2217/bmm-2018-0089DOI Listing
November 2018
1 Read

Comparison of multiple biomarkers for mortality prediction in patients with acute heart failure of ischemic and nonischemic etiology.

Biomark Med 2018 Nov 30;12(11):1207-1217. Epub 2018 Nov 30.

Department of Cardiology, Taian City Central Hospital, Tai'an, 271000, PR China.

Aim: To investigate the prognosis of soluble ST2 (sST2), galectin-3 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) for death related to ischemic and nonischemic etiology of acute heart failure (HF).

Methods: The associations between biomarkers and death were determined in 1020 patients admitted to hospital with acute HF.

Results: During 1-year follow-up, 162 patients died. Read More

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http://dx.doi.org/10.2217/bmm-2018-0123DOI Listing
November 2018
10 Reads

An accurate regression of developmental stages for breast cancer based on transcriptomic biomarkers.

Biomark Med 2019 Jan 28;13(1):5-15. Epub 2018 Nov 28.

BioKnow Health Informatics Lab, College of Computer Science & Technology, Key Laboratory of Symbolic Computation & Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin 130012, PR China.

Aim: Breast cancers at different stages have tremendous differences on both phenotypic and molecular patterns. The developmental stage is an essential factor in the clinical decision of treatment plans, but was usually formulated as a classification problem, which ignored the consecutive relationships among them.

Materials & Methods: This study proposed a regression-based procedure to detect the stage biomarkers of breast cancers. Read More

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https://www.futuremedicine.com/doi/10.2217/bmm-2018-0305
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http://dx.doi.org/10.2217/bmm-2018-0305DOI Listing
January 2019
11 Reads

Myeloperoxidase activity and acute coronary syndrome survival: long-term evaluation in the ERICO study.

Biomark Med 2018 Nov 20;12(11):1219-1229. Epub 2018 Nov 20.

Center for Clinical & Epidemiological Research, Internal Medicine Department, Hospital Universitário, Universidade de Sao Paulo, Brazil.

Aim: We aimed to analyze the influence of myeloperoxidase (MPO) activity on mortality in the Acute Coronary Syndrome Registry Strategy (ERICO) study.

Methods: MPO activity levels were evaluated in 342 patients. We performed survival analyses using Kaplan-Meier curves and Cox regression with respective hazard ratios, 95% CI, according to MPO tertiles distribution up to 7 years of follow-up. Read More

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http://dx.doi.org/10.2217/bmm-2018-0110DOI Listing
November 2018
12 Reads

The β-blocker uptitration in elderly with heart failure regarding biomarker levels: CIBIS-ELD substudy.

Biomark Med 2018 Nov 19;12(11):1261-1270. Epub 2018 Nov 19.

Department of Cardiology, Charite -Campus Virchow-Klinikum, Berlin, Germany.

Aim: We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing β-blocker uptitration in elderly patients with heart failure.

Patients & Methods: According to the biomarkers' levels, 457 patients were divided into three subgroups and compared with each other at baseline and 3 months after.

Results: All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had significant amelioration of left ventricle ejection fraction and New York Heart Association (NYHA) class after 3 months of β-blocker uptitration (p < 0. Read More

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https://www.futuremedicine.com/doi/10.2217/bmm-2018-0136
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http://dx.doi.org/10.2217/bmm-2018-0136DOI Listing
November 2018
11 Reads

How our understanding of the microbiome has changed the way we look at liver diseases.

Biomark Med 2018 Nov 16;12(11):1203-1206. Epub 2018 Nov 16.

Department of Internal Medicine I, Gastroenterology, Hepatology, Metabolism & Endocrinology, Medical University Innsbruck, Innsbruck, Austria.

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https://www.futuremedicine.com/doi/10.2217/bmm-2018-0266
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http://dx.doi.org/10.2217/bmm-2018-0266DOI Listing
November 2018
8 Reads

Urine afamin and afamin-creatinine ratio as biomarkers for kidney injury.

Biomark Med 2018 Nov 15;12(11):1241-1249. Epub 2018 Nov 15.

Department of Clinical Laboratory, Peking University First Hospital, 100034, Beijing, PR China.

Aim: The aim of this study was to evaluate the urine afamin (uAFM) and afamin-creatinine ratio (AfCR) levels in patients with glomerulonephritis.

Patients & Methods: We determined uAFM and AfCR of 247 healthy volunteers and 129 biopsy-proven glomerulonephritis patients.

Results: Analytical evaluation study revealed the assay is a reliable and robust test for measuring uAFM. Read More

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http://dx.doi.org/10.2217/bmm-2018-0126DOI Listing
November 2018
13 Reads

Early solid tumor diagnosis through next-generation sequencing of cell-free DNA.

Biomark Med 2018 Nov 31;12(11):1197-1201. Epub 2018 Oct 31.

Centre for Biosystems & Genome Network Medicine, Ioannina University, Ioannina, Greece.

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http://dx.doi.org/10.2217/bmm-2018-0269DOI Listing
November 2018
1 Read

Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer.

Biomark Med 2018 Oct 21;12(10):1185-1196. Epub 2018 Sep 21.

School of Public Health, Guangxi Medical University, Nanning 530021, PR China.

Aim: The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer.

Methods: A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed.

Results: A total of 370 articles were retrieved from PubMed and EMBASE. Read More

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http://dx.doi.org/10.2217/bmm-2017-0440DOI Listing
October 2018
2 Reads

Novel cardiovascular risk biomarkers in carotid atherogenesis.

Biomark Med 2018 Oct 19;12(10):1065-1067. Epub 2018 Sep 19.

First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy.

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http://dx.doi.org/10.2217/bmm-2018-0198DOI Listing
October 2018
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Relationship between inflammatory parameters and cardiovascular and lifestyle factors in the Mugello study oldest old.

Biomark Med 2018 Oct 11;12(10):1115-1124. Epub 2018 Sep 11.

Don Gnocchi Foundation, IRCCS, Florence, Italy.

Aim: To explore possible inter-relationships of various biomarkers of inflammation and lifestyle and other cardiovascular risk factors (age, gender, smoking history, hypertension, Type 2 diabetes, dyslipidemia, alteration of circadian rhythms, body mass index, calf circumference, thigh circumference, abdominal circumference) in the Mugello study oldest old.

Methods: In 399 noninstitutionalized nonagenarians (291 women), whole blood cells, mean platelet volume, C-reactive protein, uric acid, gamma-glutamyl transferase were assessed.

Results: Aging resulted as the only independent determinant for uric acid (<0. Read More

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http://dx.doi.org/10.2217/bmm-2017-0441DOI Listing
October 2018
3 Reads