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    1038 results match your criteria Biomarkers in Medicine [Journal]

    1 OF 21

    Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with stable angina.
    Biomark Med 2017 Sep 11. Epub 2017 Sep 11.
    Department of Cardiovascular Diseases, Civil Aviation General Hospital, Civil Aviation Clinical Medical College of Peking University, Beijing, China.
    Aim: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina.

    Methods: 133 patients with stable angina were enrolled.

    Results: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2. Read More

    A comprehensive narrative review of diagnostic biomarkers in human primary membranous nephropathy.
    Biomark Med 2017 Sep 11. Epub 2017 Sep 11.
    Urology Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Membranous nephropathy (MN) is relatively major cause of nephrotic syndrome in adults which is recognized as an organ-specific autoimmune disease. The etiology of most cases is idiopathic, whereas the secondary MN is caused by systemic autoimmune diseases, infections, medications and malignancies. The idiopathic disease is developed by the formation of sub-epithelial immune complex deposits most likely due to binding the circulating auto-antibodies to intrinsic antigen on podocytes. Read More

    Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity.
    Biomark Med 2017 Sep 11. Epub 2017 Sep 11.
    Departments of Psychiatry & Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
    In psychopathology research, endophenotypes are a subset of biomarkers that indicate genetic vulnerability independent of clinical state. To date, an explicit expectation is that endophenotypes be specific to single disorders. We evaluate this expectation considering recent advances in psychiatric genetics, recognition that transdiagnostic vulnerability traits are often more useful than clinical diagnoses in psychiatric genetics, and appreciation for etiological complexity across genetic, neural, hormonal and environmental levels of analysis. Read More

    Immune checkpoint molecule PD-1 acts as a novel biomarker for the pathological process of gestational diabetes mellitus.
    Biomark Med 2017 Sep 11. Epub 2017 Sep 11.
    Department of Immunology, School of Biology & Basic Medical Sciences, Medical College, Soochow University, Suzhou, China.
    Aim: Accumulating evidence suggested that challenge of the maternal-fetal interaction during pregnancy might cause the impairment of immunological hemostasis and lead to gestational diabetes mellitus (GDM) pathological process. Immune checkpoint molecule PD-1 is one of the critical molecule balancing immune response and immunological tolerance.

    Methods: PD-1 expressions on T-cell subsets of GDM patients and control groups were measured via flow cytometric analysis and followed up. Read More

    Association of GOLPH2 expression with survival in non-small-cell lung cancer: clinical implications and biological validation.
    Biomark Med 2017 Sep 7. Epub 2017 Sep 7.
    Department of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
    Aim: We investigated the role of GOLPH2 in non-small-cell lung cancer (NSCLC).

    Methods: We analyzed the relationship between the expression of GOLPH2 and the clinical pathological characteristics of patients with NSCLC. The function of GOLPH2 in NSCLC cell lines was also explored through overexpression and knockdown studies. Read More

    Intracranial pressure-induced optic nerve sheath response as a predictive biomarker for optic disc edema in astronauts.
    Biomark Med 2017 Sep 4. Epub 2017 Sep 4.
    Laboratory of Neurochemistry & Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, 2610 Antwerp, Belgium.
    A significant proportion of the astronauts who spend extended periods in microgravity develop ophthalmic abnormalities. Understanding this syndrome, called visual impairment and intracranial pressure (VIIP), has become a high priority for National Aeronautics and Space Administration, especially in view of future long-duration missions (e.g. Read More

    High expression of Parkin predicts easier recurrence of patients with adjuvant transarterial chemoembolization.
    Biomark Med 2017 Sep 1. Epub 2017 Sep 1.
    Department of Intervention, Linyi Cancer Hospital, Linyi, Shandong, China.
    Aim: To investigate the clinical significance of E3 ubiquitin ligase Parkin in patients with adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma.

    Methods: Parkin expression of hepatocellular carcinomas was detected and its correlation with clinicopathological factors was analyzed with χ(2) test. The significance of Parkin in prognosis and recurrence was analyzed with log-rank test and the Cox-regression model. Read More

    Prognostic value of miRNA-181a/b in colorectal cancer: a meta-analysis.
    Biomark Med 2017 Aug 25. Epub 2017 Aug 25.
    Department of General Surgery, Danyang People's Hospital of Jiangsu Province, Danyang affiliated Hospital of Nantong University, Danyang 213000, China.
    Aims: miR-181a and miR-181b have been investigated as prognostic biomarkers of colorectal cancer (CRC). However, there is controversy about the role of miR-181a and miR-181b in predicting CRC prognosis. Therefore, we performed this meta-analysis to evaluate prognostic values of miR-181a and miR-181b in CRC patients. Read More

    Oxidative stress biomarkers and burden of coronary atherosclerosis assessed based on SYNTAX score.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Cardiology, Yozgat State Hospital, Yozgat, Turkey.
    Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Read More

    Folate metabolism abnormalities in autism: potential biomarkers.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY 11203, USA.
    Autism spectrum disorder (ASD) has been linked to abnormalities in folate metabolism. Polymorphisms in folate genes may act in complex polygenic ways to increase the risk of developing ASD. Autoantibodies that block folate transport into the brain have been associated with ASD and children with ASD and these autoantibodies respond to high doses of a reduced form of folate known as folinic acid (leucovorin calcium). Read More

    Serum TNF-α, erythrocyte sedimentation rate and IL-6 are more valuable biomarkers for assisted diagnosis of extremity chronic osteomyelitis.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Orthopedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.
    Aim: This study aimed to investigate the values of preoperative serum levels of white blood cell, erythrocyte sedimentation rate (ESR), C-reactive protein, procalcitonin, IL-6, TNF-α and serum amyloid A for diagnosis of chronic osteomyelitis (COM) in Chinese patients.

    Methods: All 586 eligible patients were included for analysis.

    Results: Outcomes revealed that positive ratios of TNF-α, ESR and IL-6 lied in top three. Read More

    Novel biomarkers for systemic lupus erythematosus.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
    Systemic lupus erythematosus (SLE) is a complex and highly heterogeneous disease. By now, no novel drug has been approved by the US FDA in the past 50 years, except Belimumab, a monoclonal antibody to inhibit B-cell activating factor. The stagnating drug development of lupus may be due to our limited understanding of disease etiopathogenesis and the extreme heterogeneity of patient population. Read More

    Association of lymphocyte-monocyte ratio and monocyte-to-high-density lipoprotein ratio with the presence and severity of rheumatic mitral valve stenosis.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Cardiology Clinic, Turkey Yuksek Ihtisas Education & Research Hospital, 06100, Ankara, Turkey.
    Aim: We aimed to evaluate the relationships between monocyte-to-high-density lipoprotein ratio (MHR) and lymphocyte-to-monocyte ratio (LMR) and rheumatic mitral valve stenosis (RMVS).

    Methodology: A total of 368 patients with mitral stenosis and 80 healthy participants were included. Patients were categorized into two groups in respect to the severity of RMVS as mild-moderate group (mitral valve area ≥1. Read More

    Clinical significance of miRNA-autophagy transcript expression in patients with hepatocellular carcinoma.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Clinical Oncology Department, Faculty of Medicine, Ain Shams University.
    Aim: This study integrates autophagy transcripts miRNAs expression based on bioinformatic analysis followed by clinical validation.

    Methodology: Cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a level were investigated in the serum and tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C and healthy volunteers by quantitative real-time PCR. The prognostic power of this serum RNA panel was explored. Read More

    Amino acid profiles as potential biomarkers for pediatric cancers: a preliminary communication.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 80-211 Gdansk, Poland.
    Aim: Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease.

    Methods: Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors were enrolled in this study and compared with healthy children. Read More

    RAS mutation prevalence among patients with metastatic colorectal cancer: a meta-analysis of real-world data.
    Biomark Med 2017 Jul 27. Epub 2017 Jul 27.
    University Hospital, Frankfurt, Germany.
    Aim: A confirmed wild-type RAS tumor status is commonly required for prescribing anti-EGFR treatment for metastatic colorectal cancer. This noninterventional, observational research project estimated RAS mutation prevalence from real-world sources.

    Materials & Methods: Aggregate RAS mutation data were collected from 12 sources in three regions. Read More

    Lower circulating migration inhibitory factor protein is associated with metabolic syndrome and diabetes.
    Biomark Med 2017 Jul 13;11(7):557-568. Epub 2017 Jul 13.
    Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Aim: The controversial relationship between macrophage migration inhibitory factor (MIF) and the likelihood of cardiometabolic diseases was investigated. Results/methodology: Assayed MIF protein from 1225 adults was cross-sectionally analyzed. MIF was independently inversely associated with age, total testosterone and positively with high-density lipoprotein-cholesterol. Read More

    Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction.
    Biomark Med 2017 Jul 12. Epub 2017 Jul 12.
    Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
    Aim: Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI.

    Patients & Methods: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI. Read More

    Resistin role in development of gestational diabetes mellitus.
    Biomark Med 2017 Jul 7;11(7):579-586. Epub 2017 Jul 7.
    Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Diabetes is estimated to be one of the major causes of deaths in most countries due to its high prevalence rate, which was 8.8% in 2015. Hyperglycemia detected during pregnancy is known as gestational diabetes mellitus and it increases the potential risk of development of Type 2 diabetes in mothers with its varying prevalence rate of 1-14% in different populations. Read More

    Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus.
    Biomark Med 2017 Jul 7;11(7):569-578. Epub 2017 Jul 7.
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
    Aim: The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type 2 diabetes mellitus.

    Methods: All patients underwent resting and exercise echocardiography, including conventional parameters, E/E' ratio, global longitudinal strain and diastolic function reserve index. Plasma matrix metalloproteinase-1, TIMP-1, amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured. Read More

    Chromogranin A in the mammalian heart: expression without secretion.
    Biomark Med 2017 Jul 7;11(7):541-545. Epub 2017 Jul 7.
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation.

    Materials & Methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. Read More

    Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome.
    Biomark Med 2017 Jul 7;11(7):535-540. Epub 2017 Jul 7.
    Cardiology Department, Bozok University Hospital, 66200, Yozgat, Turkey.
    Aim: We aimed to investigate the relationships between metabolic syndrome (MS) and monocyte to high density lipoprotein cholesterol ratio (MHR) and lymphocyte-to-monocyte ratio (LMR).

    Methods: 762 patients (n = 371 MS present and n = 391 MS absent) were enrolled.

    Results: MHR was significantly higher [13. Read More

    Association of IGF-1 with coronary collateral circulation in stable coronary artery disease.
    Biomark Med 2017 Jul 7;11(7):527-534. Epub 2017 Jul 7.
    Cardiology Department, Ankara Numune Education & Research Hospital, Ankara, Turkey.
    Aim: The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease.

    Methods: Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were included in this study.

    Results: The patients with good CCC had significantly higher IGF-1 levels compared with the poor ones. Read More

    Actinin-4 protein overexpression as a predictive biomarker in adjuvant chemotherapy for resected lung adenocarcinoma.
    Biomark Med 2017 Jun 29. Epub 2017 Jun 29.
    Division of Chemotherapy & Clinical Research, National Cancer Center Research Institute, Tokyo, Japan.
    Aim: Although several clinical trials demonstrated the benefits of platinum-combination adjuvant chemotherapy for stage II-IIIA lung adenocarcinoma, predictive biomarkers for the efficacy of such therapy have not yet been identified. We evaluated protein overexpression of actinin-4 as a predictive biomarker of the efficacy of adjuvant chemotherapy in resected lung adenocarcinoma.

    Materials & Methods: We measured actinin-4 protein levels in patients with completely resected stage II-IIIA lung adenocarcinoma using immunohistochemistry and then retrospectively compared survival between adjuvant chemotherapy and observation groups. Read More

    Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile.
    Biomark Med 2017 May 23;11(6):427-438. Epub 2017 Jun 23.
    Department of Quantitative Psychology, University of Notre Dame, Notre Dame, IN, USA.
    Aim: To assess the extent to which a multivariate approach to modeling interrelated hematological indices provides more informative results than the traditional approach of modeling each index separately.

    Materials & Methods: The effects of demographics and lifestyle on ten hematological indices collected from a Dutch population-based sample (n = 3278) were studied, jointly using multivariate distance matrix regression and separately using linear regression.

    Results: The multivariate approach highlighted the main effects of all predictors and several interactions; the traditional approach highlighted only main effects. Read More

    Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.
    Biomark Med 2017 May 23;11(6):451-473. Epub 2017 Jun 23.
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program (PDBP) and other mechanisms, no single PD marker or set of markers are ready for clinical use. Here we discuss the current state of biomarker discovery for platforms relevant to PDBP. Read More

    Relationship of IL-17A and IL-17F genetic variations to cervical cancer risk: a meta-analysis.
    Biomark Med 2017 May;11(5):459-471
    Fujian Provincial Key Laboratory of Environment Factors & Cancer, School of Public Health, Fujian Medical University, Fuzhou, China.
    Aim: We performed a meta-analysis to determine a more precise relationship of IL-17A and IL-17F polymorphisms with cervical cancer risk.

    Materials & Methods: PubMed, CNKI and Wan Fang databases were searched for studies on these associations using STATA version 10.0 software. Read More

    Association of ANRIL gene polymorphisms with prostate cancer and benign prostatic hyperplasia in an Iranian population.
    Biomark Med 2017 May;11(5):413-422
    Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Aim: Prostate cancer and benign prostate hyperplasia (BPH) are heterogeneous disorders with high prevalence among men. The antisense noncoding RNA in the INK4 locus codes for a long noncoding RNA whose participation in cancer has been elucidated.

    Method: We analyzed rs1333045, rs4977574, rs1333048 and rs10757278 genotypes from this locus in 125 prostate cancer patients, 125 BPH patients as well as 220 normal age-matched subjects by means of tetra-primer amplification refractory mutation system PCR method. Read More

    Plasma microRNA-19a as a potential biomarker for esophageal squamous cell carcinoma diagnosis and prognosis.
    Biomark Med 2017 May;11(5):431-441
    Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital, Xiamen, China.
    Aim: To investigate whether plasma miR-19a can serve as a biomarker for esophageal squamous cell carcinoma (ESCC) diagnosis and prognosis.

    Materials & Methods: Plasma samples from 89 ESCC, 45 benign lesion patients and 80 healthy controls were subjected to RT-qPCR analyses for miR-19a. In addition, plasma samples from 30 patients were collected before and after surgery for the same analyses. Read More

    Gamma-glutamyltransferase activity as a surrogate biomarker of metabolic health status in young nondiabetic obese women.
    Biomark Med 2017 May;11(5):449-457
    Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
    Aim: We investigated the association of gamma-glutamyltransferase (GGT) activity with atherogenic risk factors and metabolic health status in young nondiabetic obese women.

    Methods & Results: In 140 obese women GGT activity was independently associated with BMI, triglyceride to high-density cholesterol ratio and homeostasis model assessment. Metabolically healthy but obese women had significantly lower GGT activity, associated with a normal insulin sensitivity, favorable lipid profile and apolipoprotein B to apolipoprotein AI ratio. Read More

    Preoperative serum TMAO level is a new prognostic marker for colorectal cancer.
    Biomark Med 2017 May;11(5):443-447
    Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, P.R. China.
    Aim: This study is aimed to determine whether trimethylamine-N-oxide (TMAO) is a predictor of prognosis of patients with colorectal cancer.

    Methods: Pretreatment TMAO serum levels were determined in 108 patients with colorectal cancer and 30 healthy controls.

    Results: Median serum TMAO level was significantly higher in colorectal cancer patients than in healthy controls (p < 0. Read More

    Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis.
    Biomark Med 2017 May;11(5):423-430
    Department of Hepatobiliary Surgery, Guizhou Provincial People's Hospital, Guiyang, China.
    Aim: This research is to explore the glycosylation change of alpha-1-acid glycoprotein (AGP) in hepatocellular carcinoma (HCC), cirrhosis and controls.

    Methods: The affinity chromatography and lectin affinity techniques were used to separate and enrich glycosylated AGP, and combined with mass spectrometry to identify and relatively quantify the glycopeptides from AGP.

    Results: The sialylation and fucosylation of AGP were different among HCC, cirrhosis and controls. Read More

    SLC28A3 rs7853758 as a new biomarker of tacrolimus elimination and new-onset hypertension in Chinese liver transplantation patients.
    Biomark Med 2017 Jun 16. Epub 2017 Jun 16.
    Department of Hepatobiliary Pancreatic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Aim: The effect of SLC28A3 on tacrolimus disposition and new-onset hypertension (NOHP) after liver transplantation (LT) remains unclear. Methodology & results: A total of 169 patients in two cohorts from the China Liver Transplant Registry database were included. Rs7853758 in recipients'SLC28A3 could predict tacrolimus pharmacokinetics in two sets. Read More

    Mitochondria in chronic obstructive pulmonary disease and lung cancer: where are we now?
    Biomark Med 2017 May 9;11(6):475-489. Epub 2017 Jun 9.
    Department of Otolaryngology & Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
    Recent advances in mitochondrial biogenesis have provided the emerging recognition that mitochondria do much more than 'simply providing energy for cellular function'. Currently, a constantly improving understanding of the mitochondrial structure and function has been providing valuable insights into the contribution of defects in mitochondrial metabolism to various human diseases, including chronic obstructive pulmonary disease and lung cancer. The growing interest in mitochondria research led to development of new biomedical fields in the two main smoking-related lung diseases. Read More

    Exosomal miRNAs as biomarkers in the diagnosis of liver disease.
    Biomark Med 2017 May 9;11(6):491-501. Epub 2017 Jun 9.
    School of Pharmacy, Anhui Medical University, Hefei 230032, China.
    Liver disease is a primary cause of liver-related morbidity and mortality worldwide. Currently, histological examination is the gold standard for diagnosis and classification of liver disease; however, due to its several drawbacks, including the risk of complications and sampling variability, noninvasive diagnostic options are favorable. Exosomal miRNAs have recently been considered as an important source of medical biomarkers due to being widely distributed in body fluids. Read More

    Blood protein biomarkers as diagnostic tool for ischemic stroke: a systematic review.
    Biomark Med 2017 May 9;11(6):503-512. Epub 2017 Jun 9.
    Faculty of Medicine & Health Sciences, Ghent University, Ghent, Belgium.
    Aim: This systematic review provides a summary of the blood protein biomarkers that have been studied for the diagnosis of acute ischemic stroke.

    Materials & Methods: An extensive MEDLINE (using PubMed) and Web of Knowledge search was performed. From the 354 articles found, 42 were eligible for further analysis and 25 protein biomarkers were examined. Read More

    Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo.
    Biomark Med 2017 May 9;11(6):439-449. Epub 2017 Jun 9.
    Gazi University, Faculty of Medicine, Biochemistry, Ankara, Turkey.
    Aim: To investigate the emphasis of oxidative stress in the pathogenesis of vitiligo through an evaluation of ischemia-modified albumin (IMA). Results/methodology: IMA was of higher statistical significance in patients than in the control group (IMA: 0.57 ± 0. Read More

    Circulating endothelial cells and their subsets: novel biomarkers for cancer.
    Biomark Med 2017 Jun 9. Epub 2017 Jun 9.
    Department of Oncology, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen 518020, China.
    Angiogenesis contributes to the growth of solid tumors. Antiangiogenic agents are widely used in various cancers and considerable efforts have been made in the development of novel biomarkers that can predict the outcome of an anticancer treatment. Of those, circulating endothelial cells (CECs) and their subsets constitute a surrogate tool for monitoring disease activity. Read More

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