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    1056 results match your criteria Biomarkers in Medicine [Journal]

    1 OF 22

    Exosomal microRNA: a novel biomarker for breast cancer.
    Biomark Med 2017 Nov 20. Epub 2017 Nov 20.
    The First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.
    Breast cancer is the most common invasive malignancy among females worldwide. MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression by binding to the 3'-untranslated regions of targeted mRNAs. Recently, exosomes have been recognized to play critical roles in breast cancer. Read More

    Gender-related association between uric acid, homocysteine, γ-glutamyltransferase, inflammatory biomarkers and metabolic syndrome in subjects affected by obesity.
    Biomark Med 2017 Oct 26. Epub 2017 Oct 26.
    Department of Biomedical, Surgical & Dental Sciences, University of Milan, Milan, Italy.
    Aim: Evaluation of gender-related differences in uric acid (UA), homocysteine and inflammatory biomarkers as metabolic syndrome (MetS) determinants.

    Patients & Methods: Anthropometric and routine data were obtained from 825 obese subjects (591 F, mean age 54 ± 14 years).

    Results: Hyperuricemia was 24% in both genders. Read More

    Combination of platelet count and neutrophil-lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival in metastatic advanced gastric cancer.
    Biomark Med 2017 Oct 26. Epub 2017 Oct 26.
    Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, PR China.
    Aim: The study evaluated the prognostic impact of combination of platelet count and neutrophil-lymphocyte ratio (COP-NLR) for first-line chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer patients.

    Methods: Two hundred and seventy-three patients were categorized into three COP-NLR groups (COP-NLR 0, 1, 2) according to their platelet count and neutrophil-lymphocyte ratio.

    Results: The COP-NLR 0 had a significantly higher disease control rate (93%) than the other two groups (p = 0. Read More

    Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population.
    Biomark Med 2017 Nov 20;11(11):947-955. Epub 2017 Oct 20.
    Department of Forensic Biology, West China School of Basic sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.
    Aim: The purpose of the present study is to investigate the association between the polymorphisms in AXIN1 with susceptibility to clear cell renal cell carcinoma (ccRCC).

    Materials & Methods:  A total of 284 ccRCC patients and 439 healthy volunteers were enrolled. Totally three tag single nucleotide polymorphisms in AXIN1 gene were genotyped using PCR & restriction fragment length polymorphism. Read More

    Susceptibility biomarker detection in urine exfoliate DNA.
    Biomark Med 2017 Nov 20;11(11):957-966. Epub 2017 Oct 20.
    INAIL Research - Department of Occupational & Environmental Medicine, Epidemiology & Hygiene. Via Fontana Candida 1 - 00078 Monte Porzio Catone (RM), Italy.
    Aim: The occupational biomonitoring of exposures to carcinogens is carried out by measuring dose (metabolites) and susceptibility biomarkers (gene polymorphisms) in two biological matrices: urine for metabolite detection and blood for genotyping. Blood is the most common substrate but has some disadvantages including: invasiveness of the harvesting technique; need of specialized staff and equipment; and high infection risk.

    Methods & Results: We propose our in-house approach using urine as single sample in 20 volunteers for simultaneous detection of dose and susceptibility biomarkers in order to verify efficacy and feasibility. Read More

    The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer.
    Biomark Med 2017 Oct 20. Epub 2017 Oct 20.
    Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung & Chang Gung University, 222 Maijin Road, Keelung 204, Taiwan, Republic of China.
    Aim: Thioredoxin can reduce the cysteine group of Keap1 which could induce proteasome degradation of Nrf2, PGAM5 and Bcl-xL. Nrf2 regulates redox balance and Bcl-xL is anti-apoptotic and both are important in tumor progression.

    Methods: The protein levels of Keap1, thioredoxin, PGAM5 and Bcl-xL in the normal and tumor tissues of 64 subjects with colorectal cancer (CRC) were determined by western blot. Read More

    Association between haptoglobin gene and insulin resistance in Arab-Americans.
    Biomark Med 2017 Nov 17;11(11):937-945. Epub 2017 Oct 17.
    Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA.
    Aim: To analyze associations between variation in the HP gene and lipid and glucose-related measures in Arab-Americans. Secondary analyses were performed based on sex.

    Patients & Methods: Genomic DNA was extracted from samples obtained from a previous epidemiological study of diabetes in Arab-Americans. Read More

    How useful is urinary-free cortisol in the clinic?
    Biomark Med 2017 Nov 17;11(11):1009-1016. Epub 2017 Oct 17.
    Hormones and Cancer Group, Garvan Institute of Medical Research, Sydney, Australia.
    Measurement of 24-h urine-free cortisol is frequently employed as a first-line screening and disease-monitoring test in Cushing's syndrome (CS). The quest for 'cortisol specificity' has seen the emergence of mass spectrometry (MS) based assays, particularly liquid chromatography/tandem mass spectrometry. In contrast to traditional immunoassays, liquid chromatography/tandem mass spectrometry 'free cortisol' measurement is less susceptible to 'interference' from cortisol precursors and metabolites. Read More

    The role of metabolomics in tuberculosis treatment research.
    Biomark Med 2017 Nov 17;11(11):1017-1029. Epub 2017 Oct 17.
    Human Metabolomics, School for Physical & Chemical Sciences, North-West University (Potchefstroom Campus), Private Bag X6001, Box 269, Potchefstroom 2531, South Africa.
    Despite the fact that tuberculosis (TB) is a curable disease, it still results in approximately 1.8 million deaths annually. Various inadequacies in the current TB treatment strategies are major contributors to this high disease prevalence, including the long duration of therapy, the severe side effects associated with TB drugs, treatment failure due to drug resistance, post-treatment disease relapse, and HIV co-infection. Read More

    Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives.
    Biomark Med 2017 Nov 17;11(11):11031-1040. Epub 2017 Oct 17.
    Department of General & Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
    Oxidative stress remains a major contributor to myocardial injury after ischemia followed by reperfusion (I/R) as the reperfusion of the myocardial infarction (MI) area inevitably leads to a cascade of I/R injury. This review focused on concepts of the antioxidative defense system and elucidates recent research using antioxidants like vitamin C, E and β-carotene or essential trace elements to activate compounds of antioxidative pathways in the circulation. In this context, important defense mechanisms like superoxide dismutase and glutathione peroxidase will be described. Read More

    Platelet-to-lymphocyte ratio predicts contrast-induced acute kidney injury in diabetic patients with ST-elevation myocardial infarction.
    Biomark Med 2017 Oct 4;11(10):847-856. Epub 2017 Oct 4.
    Third Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Disease, Zabrze, Poland.
    Aim: There has been a rise in contrast-induced acute kidney injury (CI-AKI). We examined the role of platelet-to-lymphocyte ratio (PLR) in predicting CI-AKI episodes in patients with myocardial infarction (MI) and diabetes.

    Methods: A total of 719 patients with diabetes and MI were enrolled. Read More

    Endostatin: a promising biomarker in the cardiovascular continuum?
    Biomark Med 2017 Oct 4;11(10):905-916. Epub 2017 Oct 4.
    Division of Family Medicine & Primary Care, Department of Neurobiology, Care Sciences & Society, Karolinska Institutet, Huddinge, Sweden.
    The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinically relevant cardiovascular biomarker. With a few exceptions, higher circulating levels of endostatin seem to reflect vascular and myocardial damage, and a worsened prognosis for cardiovascular events or mortality in individuals with hypertension, diabetes, kidney disease, cardiovascular disease, as well as in the general population. Read More

    The relationship between lymphocyte-to-monocyte ratio and saphenous vein graft patency in patients with coronary artery bypass graft.
    Biomark Med 2017 Oct 4;11(10):867-876. Epub 2017 Oct 4.
    Ankara Education & Research Hospital, Department of Cardiology, Ankara, Turkey.
    Aim: A lower lymphocyte count and a high monocyte count give important clues about the prognosis of various cardiovascular diseases. We hypothesized that lymphocyte-to-monocyte ratio (LMR) was associated with the saphenous vein graft disease (SVGD) in patients with coronary artery bypass graft (CABG).

    Patients & Methods: A total of 218 patients with previous history of CABG surgery, who underwent coronary angiography due to stable angina symptoms, were investigated, retrospectively. Read More

    Opportunities and challenges for the discovery and validation of proteomic biomarkers for common arthritic diseases.
    Biomark Med 2017 Oct 4;11(10):877-892. Epub 2017 Oct 4.
    Musculoskeletal Research Unit, Translational Health Sciences Bristol Medical School, University of Bristol, Learning & Research Building, Southmead Hospital, Bristol BS10 5NB, UK.
    Osteoarthritis (OA) and rheumatoid arthritis (RA) are most prevalent among all the rheumatic diseases, and currently, there are no reliable biochemical measures for early diagnosis or for predicting who is likely to progress. Early diagnosis is important for making decisions on treatment options and for better management of patients. This narrative review highlights the first-generation biomarkers identified over the last two decades and focuses on the discovery and validation of candidate OA biomarkers from recent mass-spectrometry-based proteomic studies for diagnosis and monitoring disease outcomes in human. Read More

    Procalcitonin in heart failure: hic et nunc.
    Biomark Med 2017 Oct 4;11(10):893-903. Epub 2017 Oct 4.
    Department of Cardiology, Zvezdara University Medical Center, Belgrade, Serbia.
    Although procalcitonin (PCT) was evaluated for the first time in the setting of heart failure (HF) in 1999, its utility in HF patients is still under examination. Patients with HF have significantly higher plasma PCT concentrations than healthy subjects and PCT levels are associated with severity of HF. It has been confirmed that higher levels of PCT are associated with worse outcomes, such as increased mortality and higher rate of rehospitalization, in HF patients with no evidence of infection. Read More

    Search for Alzheimer's disease biomarkers in blood cells: hypotheses-driven approach.
    Biomark Med 2017 Oct 4;11(10):917-931. Epub 2017 Oct 4.
    Laboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology, Polish Academy of Science, Pasteur 3 St., 02-093 Warsaw, Poland.
    Current Alzheimer's disease (AD) diagnostics is based on cognitive testing, and detecting amyloid Aβ and τ pathology by brain imaging and assays of cerebrospinal fluid. However, biomarkers identifying complex pathways contributing to pathology are lacking, especially for early AD. Preferably, such biomarkers should be more cost-effective and present in easily available diagnostic tissues, such as blood. Read More

    Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with stable angina.
    Biomark Med 2017 Nov 11;11(11):979-990. Epub 2017 Sep 11.
    Department of Cardiovascular Diseases, Civil Aviation General Hospital, Civil Aviation Clinical Medical College of Peking University, Beijing, China.
    Aim: To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina.

    Methods: 133 patients with stable angina were enrolled.

    Results: MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2. Read More

    A comprehensive narrative review of diagnostic biomarkers in human primary membranous nephropathy.
    Biomark Med 2017 Sep 11. Epub 2017 Sep 11.
    Urology Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Membranous nephropathy (MN) is relatively major cause of nephrotic syndrome in adults which is recognized as an organ-specific autoimmune disease. The etiology of most cases is idiopathic, whereas the secondary MN is caused by systemic autoimmune diseases, infections, medications and malignancies. The idiopathic disease is developed by the formation of sub-epithelial immune complex deposits most likely due to binding the circulating auto-antibodies to intrinsic antigen on podocytes. Read More

    Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity.
    Biomark Med 2017 Sep 11. Epub 2017 Sep 11.
    Departments of Psychiatry & Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.
    In psychopathology research, endophenotypes are a subset of biomarkers that indicate genetic vulnerability independent of clinical state. To date, an explicit expectation is that endophenotypes be specific to single disorders. We evaluate this expectation considering recent advances in psychiatric genetics, recognition that transdiagnostic vulnerability traits are often more useful than clinical diagnoses in psychiatric genetics, and appreciation for etiological complexity across genetic, neural, hormonal and environmental levels of analysis. Read More

    Immune checkpoint molecule PD-1 acts as a novel biomarker for the pathological process of gestational diabetes mellitus.
    Biomark Med 2017 Sep 11. Epub 2017 Sep 11.
    Department of Immunology, School of Biology & Basic Medical Sciences, Medical College, Soochow University, Suzhou, China.
    Aim: Accumulating evidence suggested that challenge of the maternal-fetal interaction during pregnancy might cause the impairment of immunological hemostasis and lead to gestational diabetes mellitus (GDM) pathological process. Immune checkpoint molecule PD-1 is one of the critical molecule balancing immune response and immunological tolerance.

    Methods: PD-1 expressions on T-cell subsets of GDM patients and control groups were measured via flow cytometric analysis and followed up. Read More

    Association of GOLPH2 expression with survival in non-small-cell lung cancer: clinical implications and biological validation.
    Biomark Med 2017 Nov 7;11(11):967-977. Epub 2017 Sep 7.
    Department of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
    Aim: We investigated the role of GOLPH2 in non-small-cell lung cancer (NSCLC).

    Methods: We analyzed the relationship between the expression of GOLPH2 and the clinical pathological characteristics of patients with NSCLC. The function of GOLPH2 in NSCLC cell lines was also explored through overexpression and knockdown studies. Read More

    Intracranial pressure-induced optic nerve sheath response as a predictive biomarker for optic disc edema in astronauts.
    Biomark Med 2017 Nov 4;11(11):1003-1008. Epub 2017 Sep 4.
    Laboratory of Neurochemistry & Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, 2610 Antwerp, Belgium.
    A significant proportion of the astronauts who spend extended periods in microgravity develop ophthalmic abnormalities. Understanding this syndrome, called visual impairment and intracranial pressure (VIIP), has become a high priority for National Aeronautics and Space Administration, especially in view of future long-duration missions (e.g. Read More

    High expression of Parkin predicts easier recurrence of patients with adjuvant transarterial chemoembolization.
    Biomark Med 2017 Oct 1;11(10):823-834. Epub 2017 Sep 1.
    Department of Intervention, Linyi Cancer Hospital, Linyi, Shandong, PR China.
    Aim: To investigate the clinical significance of E3 ubiquitin ligase Parkin in patients with adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma.

    Methods: Parkin expression of hepatocellular carcinomas was detected and its correlation with clinicopathological factors was analyzed with χ(2) test. The significance of Parkin in prognosis and recurrence was analyzed with log-rank test and the Cox-regression model. Read More

    Prognostic value of miRNA-181a/b in colorectal cancer: a meta-analysis.
    Biomark Med 2017 Aug 25. Epub 2017 Aug 25.
    Department of General Surgery, Danyang People's Hospital of Jiangsu Province, Danyang affiliated Hospital of Nantong University, Danyang 213000, China.
    Aims: miR-181a and miR-181b have been investigated as prognostic biomarkers of colorectal cancer (CRC). However, there is controversy about the role of miR-181a and miR-181b in predicting CRC prognosis. Therefore, we performed this meta-analysis to evaluate prognostic values of miR-181a and miR-181b in CRC patients. Read More

    Oxidative stress biomarkers and burden of coronary atherosclerosis assessed based on SYNTAX score.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Cardiology, Yozgat State Hospital, Yozgat, Turkey.
    Letter in regards to: Akboga MK, Balci KG, Maden O et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark. Read More

    Folate metabolism abnormalities in autism: potential biomarkers.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Medicine, State University of New York - Downstate Medical Center, Brooklyn, NY 11203, USA.
    Autism spectrum disorder (ASD) has been linked to abnormalities in folate metabolism. Polymorphisms in folate genes may act in complex polygenic ways to increase the risk of developing ASD. Autoantibodies that block folate transport into the brain have been associated with ASD and children with ASD and these autoantibodies respond to high doses of a reduced form of folate known as folinic acid (leucovorin calcium). Read More

    Serum TNF-α, erythrocyte sedimentation rate and IL-6 are more valuable biomarkers for assisted diagnosis of extremity chronic osteomyelitis.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Orthopedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.
    Aim: This study aimed to investigate the values of preoperative serum levels of white blood cell, erythrocyte sedimentation rate (ESR), C-reactive protein, procalcitonin, IL-6, TNF-α and serum amyloid A for diagnosis of chronic osteomyelitis (COM) in Chinese patients.

    Methods: All 586 eligible patients were included for analysis.

    Results: Outcomes revealed that positive ratios of TNF-α, ESR and IL-6 lied in top three. Read More

    Novel biomarkers for systemic lupus erythematosus.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
    Systemic lupus erythematosus (SLE) is a complex and highly heterogeneous disease. By now, no novel drug has been approved by the US FDA in the past 50 years, except Belimumab, a monoclonal antibody to inhibit B-cell activating factor. The stagnating drug development of lupus may be due to our limited understanding of disease etiopathogenesis and the extreme heterogeneity of patient population. Read More

    Association of lymphocyte-monocyte ratio and monocyte-to-high-density lipoprotein ratio with the presence and severity of rheumatic mitral valve stenosis.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Cardiology Clinic, Turkey Yuksek Ihtisas Education & Research Hospital, 06100, Ankara, Turkey.
    Aim: We aimed to evaluate the relationships between monocyte-to-high-density lipoprotein ratio (MHR) and lymphocyte-to-monocyte ratio (LMR) and rheumatic mitral valve stenosis (RMVS).

    Methodology: A total of 368 patients with mitral stenosis and 80 healthy participants were included. Patients were categorized into two groups in respect to the severity of RMVS as mild-moderate group (mitral valve area ≥1. Read More

    Clinical significance of miRNA-autophagy transcript expression in patients with hepatocellular carcinoma.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Clinical Oncology Department, Faculty of Medicine, Ain Shams University.
    Aim: This study integrates autophagy transcripts miRNAs expression based on bioinformatic analysis followed by clinical validation.

    Methodology: Cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a level were investigated in the serum and tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C and healthy volunteers by quantitative real-time PCR. The prognostic power of this serum RNA panel was explored. Read More

    Amino acid profiles as potential biomarkers for pediatric cancers: a preliminary communication.
    Biomark Med 2017 Aug 3. Epub 2017 Aug 3.
    Department of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 80-211 Gdansk, Poland.
    Aim: Childhood cancer remains one of the main cause of death in the pediatric population. Amino acids (AAs) level alterations in plasma are considered to play a role in carcinogenesis and further course of the disease.

    Methods: Seventy-seven children with cancer, including 47 with hematological and 30 with solid tumors were enrolled in this study and compared with healthy children. Read More

    RAS mutation prevalence among patients with metastatic colorectal cancer: a meta-analysis of real-world data.
    Biomark Med 2017 Jul 27. Epub 2017 Jul 27.
    University Hospital, Frankfurt, Germany.
    Aim: A confirmed wild-type RAS tumor status is commonly required for prescribing anti-EGFR treatment for metastatic colorectal cancer. This noninterventional, observational research project estimated RAS mutation prevalence from real-world sources.

    Materials & Methods: Aggregate RAS mutation data were collected from 12 sources in three regions. Read More

    Lower circulating migration inhibitory factor protein is associated with metabolic syndrome and diabetes.
    Biomark Med 2017 Jul 13;11(7):557-568. Epub 2017 Jul 13.
    Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Aim: The controversial relationship between macrophage migration inhibitory factor (MIF) and the likelihood of cardiometabolic diseases was investigated. Results/methodology: Assayed MIF protein from 1225 adults was cross-sectionally analyzed. MIF was independently inversely associated with age, total testosterone and positively with high-density lipoprotein-cholesterol. Read More

    Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction.
    Biomark Med 2017 Jul 12. Epub 2017 Jul 12.
    Department of Cardiology, Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, China.
    Aim: Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI.

    Patients & Methods: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI. Read More

    Resistin role in development of gestational diabetes mellitus.
    Biomark Med 2017 Jul 7;11(7):579-586. Epub 2017 Jul 7.
    Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Diabetes is estimated to be one of the major causes of deaths in most countries due to its high prevalence rate, which was 8.8% in 2015. Hyperglycemia detected during pregnancy is known as gestational diabetes mellitus and it increases the potential risk of development of Type 2 diabetes in mothers with its varying prevalence rate of 1-14% in different populations. Read More

    Relationship of biomarkers of extracellular matrix with myocardial function in Type 2 diabetes mellitus.
    Biomark Med 2017 Jul 7;11(7):569-578. Epub 2017 Jul 7.
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
    Aim: The study evaluated the relationship of extracellular matrix and renin angiotensin system with myocardial dysfunction in Type 2 diabetes mellitus.

    Methods: All patients underwent resting and exercise echocardiography, including conventional parameters, E/E' ratio, global longitudinal strain and diastolic function reserve index. Plasma matrix metalloproteinase-1, TIMP-1, amino-terminal propeptide of type I and type III procollagen and renin angiotensin system activity were measured. Read More

    Chromogranin A in the mammalian heart: expression without secretion.
    Biomark Med 2017 Jul 7;11(7):541-545. Epub 2017 Jul 7.
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation.

    Materials & Methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was sampled from the femoral vein, right atrium, coronary sinus and the left atrium from patients with predominantly atrial disease. Read More

    Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome.
    Biomark Med 2017 Jul 7;11(7):535-540. Epub 2017 Jul 7.
    Cardiology Department, Bozok University Hospital, 66200, Yozgat, Turkey.
    Aim: We aimed to investigate the relationships between metabolic syndrome (MS) and monocyte to high density lipoprotein cholesterol ratio (MHR) and lymphocyte-to-monocyte ratio (LMR).

    Methods: 762 patients (n = 371 MS present and n = 391 MS absent) were enrolled.

    Results: MHR was significantly higher [13. Read More

    Association of IGF-1 with coronary collateral circulation in stable coronary artery disease.
    Biomark Med 2017 Jul 7;11(7):527-534. Epub 2017 Jul 7.
    Cardiology Department, Ankara Numune Education & Research Hospital, Ankara, Turkey.
    Aim: The aim of the present study is to evaluate the relationship between coronary collateral circulation (CCC) grade and serum IGF-1 levels in patients diagnosed with stable coronary artery disease.

    Methods: Totally, 190 consecutive patients with stable coronary artery disease who underwent coronary angiography were included in this study.

    Results: The patients with good CCC had significantly higher IGF-1 levels compared with the poor ones. Read More

    Actinin-4 protein overexpression as a predictive biomarker in adjuvant chemotherapy for resected lung adenocarcinoma.
    Biomark Med 2017 Jun 29. Epub 2017 Jun 29.
    Division of Chemotherapy & Clinical Research, National Cancer Center Research Institute, Tokyo, Japan.
    Aim: Although several clinical trials demonstrated the benefits of platinum-combination adjuvant chemotherapy for stage II-IIIA lung adenocarcinoma, predictive biomarkers for the efficacy of such therapy have not yet been identified. We evaluated protein overexpression of actinin-4 as a predictive biomarker of the efficacy of adjuvant chemotherapy in resected lung adenocarcinoma.

    Materials & Methods: We measured actinin-4 protein levels in patients with completely resected stage II-IIIA lung adenocarcinoma using immunohistochemistry and then retrospectively compared survival between adjuvant chemotherapy and observation groups. Read More

    Using a multivariate model to assess the interactive effects of demographics and lifestyle on the hematological profile.
    Biomark Med 2017 May 23;11(6):427-438. Epub 2017 Jun 23.
    Department of Quantitative Psychology, University of Notre Dame, Notre Dame, IN, USA.
    Aim: To assess the extent to which a multivariate approach to modeling interrelated hematological indices provides more informative results than the traditional approach of modeling each index separately.

    Materials & Methods: The effects of demographics and lifestyle on ten hematological indices collected from a Dutch population-based sample (n = 3278) were studied, jointly using multivariate distance matrix regression and separately using linear regression.

    Results: The multivariate approach highlighted the main effects of all predictors and several interactions; the traditional approach highlighted only main effects. Read More

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