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    1100 results match your criteria Biomarkers in Medicine [Journal]

    1 OF 22

    Biomarkers for Sjögren's syndrome.
    Biomark Med 2018 Feb 20. Epub 2018 Feb 20.
    Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Pisa, 56126, Italy.
    Sjögren's syndrome (pSS) is a complex and heterogeneous disorder characterized by different clinical subsets. Recently, great efforts have been made searching for reliable biomarkers able to ameliorate the diagnostic algorithm and the prognostic stratification of pSS patients and ultimately allowing the scientific community to address some of the unmet needs for the disease. In this review, we have summarized the state of the art of 'traditional' widely acknowledged clinical, serological and histologic biomarkers for pSS with the aim of highlighting their relevance and limitations in clinical practice. Read More

    Sex hormone-binding globulin levels during the first trimester may predict gestational diabetes mellitus development.
    Biomark Med 2018 Feb 20. Epub 2018 Feb 20.
    Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.
    Aim: To investigate the association of sex hormone-binding globulin (SHBG) levels of early pregnancy with gestational diabetes mellitus (GDM) development.

    Methods: A total of 443 pregnant women during the first trimester (<12 weeks) were enrolled. SHBG levels were measured. Read More

    PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease.
    Biomark Med 2018 Feb 14. Epub 2018 Feb 14.
    División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, 86205, Tabasco, México.
    Aim: Investigate the correlation between paraoxonase 2 (PON2) Ser311Cys polymorphism as well as the peroxisome proliferator-activated receptor gamma (PPARG) His477His polymorphism and the susceptibility to development of coronary heart diseases (CHD) through a meta-analysis.

    Methods: Odds ratio and the corresponding 95% CI were used to assess the results. We included 7476 CHD patients and 8504 healthy controls. Read More

    Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome.
    Biomark Med 2018 Feb 14. Epub 2018 Feb 14.
    Department of Sleep Medicine Center, NanFang Hospital, Southern Medical University, Guangzhou 510515, PR China.
    Aim: To evaluate various biomarkers of metabolism, immunity and inflammation in obstructive sleep apnea hypopnea syndrome (OSAHS).

    Materials & Methods: After overnight polysomnography, blood was collected from 292 OSAHS patients or healthy volunteers. Serum content of inflammatory, immune, metabolic biomarkers were investigated. Read More

    Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma.
    Biomark Med 2018 Feb 14. Epub 2018 Feb 14.
    Department of Biomedical Research, Armed Forces College of Medicine (AFCM), Cairo, 11774, Egypt.
    Aim: We aimed to examine the statistical association between serum expression of miRNA 661 (miR-661) and ATG-4B mRNA and hepatocellular carcinoma (HCC) based on in silico data analysis followed by clinical validation.

    Patients & Methods: Quantitative reverse-transcriptase real-time PCR was used to examine the expression of miR-661 and ATG-4B mRNA in the sera of HCC patients versus control.

    Results: The expression of miR-661 and ATG-4B mRNA was positive in 97. Read More

    Biophysical properties of extracellular vesicles in diagnostics.
    Biomark Med 2018 Feb 14. Epub 2018 Feb 14.
    Department of Molecular & Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
    Extracellular vesicles (EVs) are cell-derived nanoparticles, involved in cell-to-cell communication, in both normal and pathological processes. Originating by the outward budding of the plasma membrane or released by exocytosis, they are natural cargoes for lipids, carbohydrates, proteins and nucleic acids. EV-based diagnostics promises unique advantages compared with conventional strategies involving whole body fluid analysis, including the reduction of biofluids complexity and more specific and sensitive detection of low abundance biomacromolecules. Read More

    Thiol/disulphide homeostasis in thoracic aortic aneurysm and acute aortic syndrome.
    Biomark Med 2018 Feb 13. Epub 2018 Feb 13.
    Department of Cardiology, Adana Numune Training & Research Hospital, Adana, Turkey.
    Aim: The aim of this study was to evaluate whether ranging values of thiol and disulphide herald a dilatation or impending acute aortic syndrome at thoracic aorta. Results/methodology: Study population consisted of patients with aortic aneurysm (n = 58), with acute aortic syndrome (n = 32) and without aortic aneurysm (control group; n = 61). A spectrophotometric method was used to determine thiol and disulphide. Read More

    Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival.
    Biomark Med 2018 Feb 13. Epub 2018 Feb 13.
    Life & Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.
    Aim: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients.

    Patients & Methods: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. Read More

    Carbohydrate antigen 125: a promising tool for risk stratification in heart diseases.
    Biomark Med 2018 Feb 9. Epub 2018 Feb 9.
    Universidade de Pernambuco, PROCAPE, Recife, Brazil.
    All patients with heart diseases should undergo risk stratification to predict those who are at high risk for short- and long-term adverse outcomes. Carbohydrate antigen 125 (CA125) is a glycoprotein produced by mesothelium that has clinical role in ovarian cancer monitoring. However, as it is not specific for ovarian cells, CA125 could also be used in heart diseases to monitor congestion and inflammation. Read More

    Proteomic biomarkers for lung cancer progression.
    Biomark Med 2018 Feb 9. Epub 2018 Feb 9.
    College of Computer Science & Technology, & Key Laboratory of Symbolic Computation & Knowledge Engineering of Ministry of Education, Jilin University, Changchun, Jilin 130012, China.
    Aim: Lung adenocarcinoma (LUAD) and lung squamous-cell carcinoma (LUSC) are two major subtypes of lung cancer and constitute about 70% of all the lung cancer cases. The patient's lifespan and living quality will be significantly improved if they are diagnosed at an early stage and adequately treated. Methodology & results: This study comprehensively screened the proteomic dataset of both LUAD and LUSC, and proposed classification models for the progression stages of LUAD and LUSC with accuracies 86. Read More

    FABP4 as a biomarker for knee osteoarthritis.
    Biomark Med 2018 Feb;12(2):107-118
    Department of Orthopaedics & Traumatology, The University of Hong Kong, Hong Kong SAR 999077, PR China.
    Aim: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA).

    Methods: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. Read More

    Evaluation of serum cysteine-rich protein 61 levels in patients with coronary artery disease.
    Biomark Med 2018 Jan 18. Epub 2018 Jan 18.
    Division of Cardiology, Shenzhen Tenth People's Hospital, Shenzhen, Guangdong, China.
    Aim: The aim is to evaluate serum cysteine-rich protein 61 (Cyr61) levels in patients with coronary artery disease (CAD).

    Patients & Methods: Serum Cyr61 levels were measured in 180 patients with CAD and 74 participants without CAD.

    Results: Serum Cyr61 levels were significantly higher in CAD patients. Read More

    Clinical evaluation of circulating miR-548a-3p and -20a expression in malignant pleural mesothelioma patients.
    Biomark Med 2018 Feb 17;12(2):129-139. Epub 2018 Jan 17.
    Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Aim: miRNAs may act as promising diagnostic and prognostic biomarkers of mesothelioma. This study integrates serum  miR-548a-3p and miR-20a expression based on in silico data analysis followed by clinical validation in malignant mesothelioma patients (malignant pleural mesothelioma [MPM]).

    Patients & Methods: Serum miR-548a-3p and  miR-20a level was assessed in the serum of patients with MPM, chronic asbestos exposure and healthy volunteers by quantitative real-time PCR. Read More

    The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017.
    Biomark Med 2018 Feb 12;12(2):101-103. Epub 2018 Jan 12.
    Department of Immunochemistry, University Hospital Pilsen, Edvarda Benese 1128/13, Pilsen, 305 99, Czech Republic.
    The 44th Congress of the International Society of Oncology and Biomarkers: Rio de Janeiro, Brazil, 7-10 September 2017 The 44th congress followed the previous one of  International Society of Oncology and Biomarkers (ISOBM) that took place in Chicago (USA) in 2016. The title of the 44th Annual congress was: 'Biomarkers in oncology: new horizons and challenges in the diagnosis and treatment of cancer' [ 1 ]. The congress was co-organized by ISOBM, European Group on Tumor Markers (EGTM) and Brazilian Society of Clinical Pathology SBPC/ML. Read More

    Syndecan-1 as a biomarker for sepsis survival after major abdominal surgery.
    Biomark Med 2018 Feb 12;12(2):119-127. Epub 2018 Jan 12.
    Department of Anesthesiology, Center of Anesthesiology & Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany.
    Aim: Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis.

    Materials & Methods: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay. Read More

    Population-based serum omentin-1 levels: paradoxical association with cardiometabolic disorders primarily in men.
    Biomark Med 2018 Feb 12;12(2):141-149. Epub 2018 Jan 12.
    Biochemistry Laboratory, Institute of Cardiology, Istanbul University, Istanbul, Turkey.
    Aim: The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Read More

    Endothelial cell-derived microvesicles: potential mediators and biomarkers of pathologic processes.
    Biomark Med 2018 Feb 12;12(2):161-175. Epub 2018 Jan 12.
    First Faculty of Medicine, Institute of Pathological Physiology, Charles University, Prague, Czech Republic.
    This review focuses on the formation, composition and function of endothelial microvesicles (MV), often called microparticles (MP). MV release is a controlled event and is considered a hallmark of cellular activation or alteration. MV may affect the function of target cells through surface interaction and receptor activation, cellular fusion and the delivery of intravesicular cargo. Read More

    The pretransplant neutrophil-lymphocyte ratio as a new prognostic predictor after liver transplantation for hepatocellular cancer: a systematic review and meta-analysis.
    Biomark Med 2018 Feb 12;12(2):189-199. Epub 2018 Jan 12.
    Department of General Surgery, Qinghai Provincial People's Hospital, Xi'ning 810000, China.
    Aim: Recently, many reports showed that the pretransplant neutrophil-lymphocyte ratio (NLR) may be correlated with the prognosis of patients undergoing liver transplantation (LT) for hepatocellular cancer (HCC). However, their results still remained controversial. Thus we performed a meta-analysis of 13 studies to estimate the prognostic value of pretransplant NLR. Read More

    Multiparametric MRI for early detection of diffuse liver disease: an interview with David Breen.
    Biomark Med 2018 Feb 10;12(2):105-106. Epub 2018 Jan 10.
    Consultant Abdominal Radiologist, Associate Professor of Radiology, University Hospital of Southampton, Southampton, UK.
    David J Breen is Associate Professor of Radiology and previous Clinical Director of Radiology at University Hospital Southampton. His interests are in abdominal imaging and intervention, particularly of hepato-pancreato-biliary (HPB)and renal disease. He has a major interest in image-guided tumor ablation and improving outcomes from these procedures. Read More

    Galectin-3 and outcomes after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention.
    Biomark Med 2018 Jan 15;12(1):21-26. Epub 2017 Dec 15.
    Division of Cardiology, ASST - Hospital of Cremona, Cremona, Italy.
    Aim: Galectin-3 (Gal-3), a biomarker of inflammation, tissue repair and fibrogenesis, is associated to left ventricular remodeling after ST-elevated myocardial infarction (STEMI), but its relation with long-term outcomes is unclear.

    Methods: In 103 consecutive patients with a first anterior STEMI treated by primary angioplasty, we assayed Gal-3 and NT-proBNP.

    Results: Age was 65 (56-76) years, 28% were women. Read More

    Gas6 as a predictor of esophageal varices in patients affected by hepatitis C virus related-chronic liver disease.
    Biomark Med 2018 Jan 15;12(1):27-34. Epub 2017 Dec 15.
    Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara, Italy.
    Aim: Plasma Gas6 was tested as an alternative to Baveno VI criteria (liver stiffness <20 kPa and platelet count >150 × 10/l) in an endoscopy-sparing strategy.

    Methods:  A total of 160 patients with chronic hepatitis C and advanced fibrosis/cirrhosis underwent, on the same occasion, liver elastography, upper endoscopy, a platelet count and serum Gas6 measurement.

    Results:  A total of 74/160 (46%) patients had esophageal varices, that were small (diameter <5 mm) in 57/160 (34%) and large in 17/160 (11%) cases. Read More

    Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors.
    Biomark Med 2018 Jan 15;12(1):35-44. Epub 2017 Dec 15.
    Institute of Orthopedics & Traumatology, Faculty of Medicine, University of São Paulo (FMUSP), São Paulo, SP, Brazil.
    Aim: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. Read More

    Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma.
    Biomark Med 2018 Jan 15;12(1):45-61. Epub 2017 Dec 15.
    Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
    Aim: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Read More

    Clinicopathological significance of Bmi-1 overexpression in esophageal cancer: a meta-analysis.
    Biomark Med 2018 Jan 14;12(1):71-81. Epub 2017 Dec 14.
    Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Xinjiang 832002, PR China.
    Aim: The clinicopathological effects of Bmi-1 expression in esophageal cancer remain widely disputed. Our aim was to clarify this relationship.

    Methods: Available studies were retrieved from diverse databases. Read More

    Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values.
    Biomark Med 2018 Jan 14;12(1):11-20. Epub 2017 Dec 14.
    Department of Biochemistry & Molecular Biology, & Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, PR China.
    Aim: To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer.

    Methods: The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed. Read More

    Lipid biomarkers for the peroxisomal and lysosomal disorders: their formation, metabolism and measurement.
    Biomark Med 2018 Jan 13;12(1):83-95. Epub 2017 Dec 13.
    Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
    Lipid biomarkers play important roles in the diagnosis of and monitoring of treatment in peroxisomal disorders and lysosomal storage disorders. Today, a variety of lipids, including very long chain fatty acids, glycolipids, bile acids and the oxidation products of cholesterol, have been considered as biomarkers for these disorders. In this brief review, the authors summarized the recent advances regarding these lipid biomarkers in terms of their formation, metabolism and measurement in these disorders. Read More

    MicroRNAs as potential prognosticators of neurological outcome in out-of-hospital cardiac arrest patients.
    Biomark Med 2017 Dec 8;11(12):1113-1123. Epub 2017 Dec 8.
    Department of Emergency Medicine, University of Florida, 1329, SW 16th Street, Suite 5270, Gainesville, FL 32608, USA.
    Out-of-hospital cardiac arrest survival rates have increased due to advancement in resuscitative measures, yet approximately 90% of survivors ultimately die or have severe neurologic dysfunction caused by ischemic injury. Currently, there are few early prognostic indicators of which patients have possibility of meaningful recovery. This leads to uncertainty for families and clinicians, as well as aggressive, invasive and expensive treatments despite medical futility. Read More

    Clinical significance of serum anti-GM-CSF autoantibody levels in autoimmune pulmonary alveolar proteinosis.
    Biomark Med 2018 Feb 5;12(2):151-159. Epub 2017 Dec 5.
    Medical Clinic, Aichi Medical University Hospital, Aichi, Japan.
    Aim: Precise clinical significance of antigranulocyte-macrophage colony stimulating factor (GM-CSF) autoantibody levels in autoimmune pulmonary alveolar proteinosis (aPAP) has not been well studied.

    Methods: We obtained sera from 50 healthy controls, 46 aPAP patients, 50 with sarcoidosis, 52 with idiopathic interstitial pneumonia and 75 with pneumoconiosis. The clinical course of aPAP patients was assessed by scoring computed tomography images in 19 patients. Read More

    The need for immune biomarkers for treatment prognosis and response in genitourinary malignancies.
    Biomark Med 2017 Dec 30;11(12):1149-1159. Epub 2017 Nov 30.
    Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
    Immune biomarkers encompass a wide range of blood-borne and cell-associated molecules whose detection or expression may change in response to an immune therapy. These immune therapies encompass a range of platforms including autologous cellular products, in other words, dendritic cells, prime boost DNA vaccines, chimeric antigen receptor (CAR) T cells and checkpoint inhibitors. The response to checkpoint inhibitors by a particular cancer may not be necessarily associated with a change in a particular immune biomarker; other immune biomarkers are needed to assess their association with treatment response or a change in the biology that can impact on the immunologic milieu. Read More

    Biomarkers of ocular surface disease using impression cytology.
    Biomark Med 2017 Dec 28;11(12):1135-1147. Epub 2017 Nov 28.
    Vision Sciences, Dept. of Life Sciences, Glasgow Caledonian University, G4 0BA, Scotland, UK.
    Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorder associated with ageing, contact lens wear, autoimmune disorders and refractive (LASIK) surgery. IC may also be utilized in the diagnosis of other ocular diseases, such as keratoconus and thyroid orbitopathy. Read More

    Toward the clinical use of circulating biomarkers predictive of bone union.
    Biomark Med 2017 Dec 28;11(12):1125-1133. Epub 2017 Nov 28.
    Servei de Teràpia Cel·lular, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain.
    Current methods for diagnosis of bone healing after treatment of trauma injuries rely on clinical findings and the use of imaging methodologies that provide conclusive results but only at mid/long-term post-intervention. In this Perspective we present and discuss incipient evidence on biomarkers that may serve for monitoring the progression of bone healing as well as predicting eventual nonunion outcomes. Read More

    Aberrant expression of PlncRNA-1 and TUG1: potential biomarkers for gastric cancer diagnosis and clinically monitoring cancer progression.
    Biomark Med 2017 Dec 28;11(12):1077-1090. Epub 2017 Nov 28.
    Department of Genetics & Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Aim: To evaluate PlncRNA-1, TUG1 and FAM83H-AS1 gene expression and their possible role as a biomarker in gastric cancer (GC) progression.

    Patients & Methods: Long noncoding RNA expressions and clinicopathological characteristics were assessed in 70 paired GC tissues. Furthermore, corresponding data from 318 GC patients were downloaded from The Cancer Genome Atlas database. Read More

    IL-1β gene polymorphism and serum levels in a Tunisian population with acute heart failure.
    Biomark Med 2017 Dec 28;11(12):1069-1076. Epub 2017 Nov 28.
    Research Laboratory (LR12SP18), University of Monastir, 5000 Monastir, Tunisia.
    Aim: The aim of this study was to explore the relationship between IL-1β-31T/C polymorphism and serum levels of IL-1β and the risk of acute heart failure (AHF).

    Methods: A total of 320 dyspnea patients (160 with AHF and 160 without AHF) and 100 healthy subjects were included in this study. IL-1β genotyping was performed by PCR-restriction fragment length polymorphism technique. Read More

    Single nucleotide polymorphisms in TNF are associated with susceptibility to aspirin-exacerbated respiratory disease but not to cytokine levels: a study in Mexican mestizo population.
    Biomark Med 2017 Dec 27;11(12):1047-1055. Epub 2017 Nov 27.
    HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Tlalpan 4502, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.
    Aim: To evaluate the association of three single nucleotide polymorphisms in TNF and one in LTA in Mexican patients with aspirin-exacerbated respiratory disease (AERD) and the correlation of those single nucleotide polymorphisms with serum levels of TNF-α.

    Patients & Methods: Case-control study including 133 patients with AERD, 135 patients with asthma (aspirin-tolerant asthmatics) and 182 healthy subjects.

    Results: GA genotype of rs1800629 in TNF was found to be associated with the risk of developing AERD (p < 0. Read More

    platelet-lymphocyte ratio in prediction of outcome of acute heart failure.
    Biomark Med 2018 Jan 27;12(1):63-70. Epub 2017 Nov 27.
    Department of Anesthesiology, State University of New York at Buffalo, Buffalo, NY 14214, USA.
    Aim: To examine the role of the ratios of platelet or neutrophil to lymphocyte count (PLR or NLR) in predicting hospital death and long-term mortality in acute heart failure (AHF). Methods & materials: The records of 554 admissions from 354 patients discharged from VAWNY with AHF between 2011 and 2015 were reviewed. The associations between admission PLR or NLR and hospital and long-term mortality were assessed by univariate and multivariate analyses. Read More

    Predicting tuberculosis treatment outcome using metabolomics.
    Biomark Med 2017 Dec 27;11(12):1057-1067. Epub 2017 Nov 27.
    School for Physical & Chemical Sciences, Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag x6001, Box 269, Potchefstroom 2531, South Africa.
    Aim: Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and unsuccessful treatment outcome were collected at baseline and analyzed. The identified metabolites were used in a forward logistic regression model, which achieved a receiver operating characteristic area under the curve of 0. Read More

    Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery.
    Biomark Med 2017 Dec 27;11(12):1091-1102. Epub 2017 Nov 27.
    Division of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
    Aim: To investigate early postoperative biomarkers for risk discrimination of advanced acute kidney injury (AKI).

    Materials & Methods: Postoperative plasma biomarkers including NGAL, h-FABP, CK-MB, hsTNT, NT-proBNP, IL-6, IL-10 and VEGF were analyzed using group-based method among 426 patients with AKI after cardiac surgery.

    Results: Six patient groups with distinct biomarker patterns were identified. Read More

    Effects of hepato-preferential basal insulin peglispro on nuclear magnetic resonance biomarkers lipoprotein insulin resistance index and GlycA in patients with diabetes.
    Biomark Med 2017 Nov;11(11):991-1001
    Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
    Aim: To characterize the effects of hepato-preferential basal insulin peglispro (BIL) and insulin glargine on insulin resistance (lipoprotein insulin resistance index [LP-IR]) and inflammation (GlycA), and to explore the biological implications.

    Methods: This substudy included 847 patients with Type 1 diabetes (T1D) or Type 2 diabetes (T2D) in four cohorts of the BIL development program. LP-IR and GlycA were measured before and after insulin treatment. Read More

    Exosomal microRNA: a novel biomarker for breast cancer.
    Biomark Med 2018 Feb 20;12(2):177-188. Epub 2017 Nov 20.
    The First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.
    Breast cancer is the most common invasive malignancy among females worldwide. microRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression by binding to the 3'-untranslated regions of targeted mRNAs. Recently, exosomes have been recognized to play critical roles in breast cancer. Read More

    Gender-related association between uric acid, homocysteine, γ-glutamyltransferase, inflammatory biomarkers and metabolic syndrome in subjects affected by obesity.
    Biomark Med 2017 Oct 26. Epub 2017 Oct 26.
    Department of Biomedical, Surgical & Dental Sciences, University of Milan, Milan, Italy.
    Aim: Evaluation of gender-related differences in uric acid (UA), homocysteine and inflammatory biomarkers as metabolic syndrome (MetS) determinants.

    Patients & Methods: Anthropometric and routine data were obtained from 825 obese subjects (591 F, mean age 54 ± 14 years).

    Results: Hyperuricemia was 24% in both genders. Read More

    Combination of platelet count and neutrophil-lymphocyte ratio as a prognostic marker to predict chemotherapeutic response and survival in metastatic advanced gastric cancer.
    Biomark Med 2017 Oct 26. Epub 2017 Oct 26.
    Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, PR China.
    Aim: The study evaluated the prognostic impact of combination of platelet count and neutrophil-lymphocyte ratio (COP-NLR) for first-line chemotherapeutic response and survival outcomes in metastatic advanced gastric cancer patients.

    Methods: Two hundred and seventy-three patients were categorized into three COP-NLR groups (COP-NLR 0, 1, 2) according to their platelet count and neutrophil-lymphocyte ratio.

    Results: The COP-NLR 0 had a significantly higher disease control rate (93%) than the other two groups (p = 0. Read More

    Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population.
    Biomark Med 2017 Nov 20;11(11):947-955. Epub 2017 Oct 20.
    Department of Forensic Biology, West China School of Basic sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.
    Aim: The purpose of the present study is to investigate the association between the polymorphisms in AXIN1 with susceptibility to clear cell renal cell carcinoma (ccRCC).

    Materials & Methods:  A total of 284 ccRCC patients and 439 healthy volunteers were enrolled. Totally three tag single nucleotide polymorphisms in AXIN1 gene were genotyped using PCR & restriction fragment length polymorphism. Read More

    Susceptibility biomarker detection in urine exfoliate DNA.
    Biomark Med 2017 Nov 20;11(11):957-966. Epub 2017 Oct 20.
    INAIL Research - Department of Occupational & Environmental Medicine, Epidemiology & Hygiene. Via Fontana Candida 1 - 00078 Monte Porzio Catone (RM), Italy.
    Aim: The occupational biomonitoring of exposures to carcinogens is carried out by measuring dose (metabolites) and susceptibility biomarkers (gene polymorphisms) in two biological matrices: urine for metabolite detection and blood for genotyping. Blood is the most common substrate but has some disadvantages including: invasiveness of the harvesting technique; need of specialized staff and equipment; and high infection risk.

    Methods & Results: We propose our in-house approach using urine as single sample in 20 volunteers for simultaneous detection of dose and susceptibility biomarkers in order to verify efficacy and feasibility. Read More

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