851,356 results match your criteria Biomarkers : biochemical indicators of exposure response and susceptibility to chemicals[Journal]


Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer's disease.

Ann Clin Transl Neurol 2020 Jul 7. Epub 2020 Jul 7.

Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, 44195.

Objective: To determine the inflammatory analytes that predict clinical progression and evaluate their performance against biomarkers of neurodegeneration.

Methods: A longitudinal study of MCI-AD patients in a Discovery cohort over 15 months, with replication in the Alzheimer's Disease Neuroimaging Initiative (ADNI) MCI cohort over 36 months. Fifty-three inflammatory analytes were measured in the CSF and plasma with a RBM multiplex analyte platform. Read More

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http://dx.doi.org/10.1002/acn3.51109DOI Listing

Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.

Diabet Med 2020 Jul 7. Epub 2020 Jul 7.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.

Aim: Misclassification of diabetes is common due to an overlap in the clinical features of type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and biomarker information have recently been developed that can aid classification, but they have not been validated using pancreatic pathology. We evaluated a clinical diagnostic model against histologically defined type 1 diabetes. Read More

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http://dx.doi.org/10.1111/dme.14361DOI Listing

Trace elements in different tissues in aging rats.

J Trace Elem Med Biol 2020 Jul 1;62:126604. Epub 2020 Jul 1.

Department of Pathological Physiology, Faculty of Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia. Electronic address:

Background: Trace elements (TE) in the human body provide a connecting link between the environment, lifestyle and biochemical modulation of homeodynamics. On the other hand, many non-essential (toxic) elements are linked to numerous diseases. Our study tried to identify differences in TE levels between healthy old and young Wistar rats in blood and the tissues of kidney, liver, heart, and testicles. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126604DOI Listing

AVNet: A retinal artery/vein classification network with category-attention weighted fusion.

Comput Methods Programs Biomed 2020 Jun 25;195:105629. Epub 2020 Jun 25.

College of Computer Science, Nankai University, Tianjin, China; Key Laboratory for Medical Data Analysis and Statistical Research of Tianjin, China. Electronic address:

Background And Objective: Automatic artery/vein (A/V) classification in retinal images is of great importance in detecting vascular abnormalities, which may provide biomarkers for early diagnosis of many systemic diseases. It is intuitive to apply popular deep semantic segmentation network for A/V classification. However, the model is required to provide powerful representation ability since vessel is much more complex than general objects. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105629DOI Listing

A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes.

Neuroimage 2020 Jul 4:117138. Epub 2020 Jul 4.

University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, University Hospital Cologne , Cologne, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, Johanniter Hospital Oberhausen, Oberhausen, Germany.

Closed-loop neuromodulation is presumed to be the logical evolution for improving the effectiveness of deep brain stimulation (DBS) treatment protocols [1]. Identifying symptom-relevant biomarkers that provide meaningful feedback to stimulator devices is an important initial step in this direction. This report demonstrates a technique for assaying neural circuitry hypothesized to contribute to OCD and DBS treatment outcomes. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117138DOI Listing

Inspiratory muscle dysfunction and restrictive lung function impairment in congenital heart disease: Association with immune inflammatory response and exercise intolerance.

Int J Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiology III, University Hospital Muenster, Muenster, Germany.

Background: In adult patients with congenital heart disease (ACHD), both underlying disease and lung restriction contribute to exercise intolerance. In ACHD the yet incompletely understood mechanism underlying restricted ventilation may be inspiratory muscle weakness. Therefore, this study comprehensively evaluated inspiratory muscle function in ACHD and associations with systemic inflammation and the clinical severity of exercise intolerance. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.055DOI Listing

A panel of circulating long non-coding RNAs as liquid biopsy biomarkers for breast and cervical cancers.

Biochimie 2020 Jul 4. Epub 2020 Jul 4.

Department of Zoology, Central University of Punjab, Bathinda, Punjab, India. Electronic address:

The early detection and diagnosis of cancer is critical to optimize the treatment and management of cancer patients. Typical methods such as imaging and tissue biopsy are invasive, time-consuming, and often imprecise. Thus, recent technological advances of dependable, facile, and minimally invasive collectible oncogenic biomarkers using human biofluids and secretions have been an active area of research. Read More

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http://dx.doi.org/10.1016/j.biochi.2020.06.012DOI Listing

The protective effect of Xanthoceras sorbifolia Bunge husks on cognitive disorder based on metabolomics and gut microbiota analysis.

J Ethnopharmacol 2020 Jul 4:113094. Epub 2020 Jul 4.

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China; National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control, China.

Aim Of The Study: The husks of Xanthoceras sorbifolia Bunge mainly used in north China as folk medicine were reported to have potential protective effect on cognitive impairment. However, the mechanism remains unclear. In order to fully understand the mechanism of the protection, a complementary study of the husks was conducted. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113094DOI Listing

The clinical application and potential roles of circulating tumor cells in bladder cancer and prostate cancer.

Urology 2020 Jul 4. Epub 2020 Jul 4.

Clinic and Polyclinic of Urology, Pediatric Urology and Andrology, JLU Giessen. Electronic address:

Circulating tumor cells (CTCs) are considered to be promising biomarkers in malignant diseases. Recently, molecular profiles of CTCs in prostate cancer (PCa) and the role of CTCs in neoadjuvant chemotherapy and transurethral resections of bladder cancer (BCa) are intensely studied. However, localized PCa and non-muscle-invasive BCa are less investigated and discussed. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.039DOI Listing

Circulating microRNAs differentiate Kawasaki Disease from infectious febrile illnesses in childhood.

J Mol Cell Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Kawasaki Disease (KD) is an acute vasculitis of unknown etiology in children that can lead to coronary artery lesions (CAL) in 25% of untreated patients. There is currently no diagnostic test for KD, and the clinical presentation is often difficult to differentiate from other febrile childhood illnesses. Circulating microRNAs (miRNAs) are small noncoding RNA molecules that control gene expression by inducing transcript degradation or by blocking translation. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2020.06.011DOI Listing

Preoperative C-reactive protein-to-albumin ratio predicts long-term outcomes in extrahepatic cholangiocarcinoma patients.

J Surg Oncol 2020 Jul 7. Epub 2020 Jul 7.

Division of Gastroenterological, Department of Surgery, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

Background: Systemic inflammation may have prognostic value in some malignancies and association with lymph node metastasis. This study aimed to evaluate the impact of systemic inflammatory biomarkers on long-term and oncological outcomes as well as to assess the association between biomarkers with lymph node metastasis in extrahepatic cholangiocarcinoma patients.

Methods: We enrolled 271 consecutive patients who underwent surgical resection for extrahepatic cholangiocarcinoma. Read More

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http://dx.doi.org/10.1002/jso.26109DOI Listing

PTEN and ERG expression in MRI-ultrasound guided fusion biopsy correlated with radical prostatectomy findings in men with prostate cancer.

Prostate 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology (HUS Diagnostic Center) and Medicum, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Conventional systematic prostate biopsies (SBx) have multiple limitations, and magnetic resonance imaging (MRI)-ultrasound fusion targeting is increasingly applied (fusion biopsies [FBx]). In our previous studies, we have shown that loss of the tumor suppressor gene phosphatase and tensin homolog (PTEN) in radical prostatectomy (RP) specimens predicts poor disease-specific survival, and in active surveillance (AS), PTEN loss in SBx predicts an adverse AS outcome, although SBx PTEN status does not correlate well with the corresponding RP status. Here, we have hypothesized that PTEN and erythroblast transformation-specific related gene (ERG) status in FBx correlate better with RP than they would in SBx. Read More

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http://dx.doi.org/10.1002/pros.24040DOI Listing

Evaluation of biochemical profile of dairy cows with metabolic diseases in tropical conditions.

Reprod Domest Anim 2020 Jul 7. Epub 2020 Jul 7.

Department of Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Sciences, University of São Paulo, 87 Professor Orlando Marques de Paiva Avenue, São Paulo, SP, 05508-010, Brazil.

The aims of this study were to characterize the biochemical profile, the reproductive performance and to identify potential predictive biomarkers of disease state of dairy cows with hyperketonemia, lipomobilization and hypocalcemia raised in tropical conditions in southeastern Brazil. Dairy cows (n = 50) were divided into a group of healthy cows (n = 14), cows with lipomobilization (n = 14), cows with hypocalcemia (n = 11), and a group of cows with hyperketonemia (n = 11). Evaluation of body condition score (BCS), body weight (BW) and blood samples were performed on 21, 14, 7, 4, and 2 days before calving, parturition, 1, 7, 14, 21, 30, 45 and 60 days postpartum and milk production was recorded on days 7, 14, 21, 30, 45 and 60 after parturition. Read More

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http://dx.doi.org/10.1111/rda.13768DOI Listing

Investigation of the therapeutic effect of Shaoyao Gancao decoction on CCL -induced liver injury in rats by metabolomic analysis.

Biomed Chromatogr 2020 Jul 7:e4940. Epub 2020 Jul 7.

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, China.

Shaoyao Gancao decoction (SGD) is a famous Chinese traditional prescription for treating liver injury. In this research, we investigated the liver protective effects of SGD and its metabolic mechanisms by H-NMR and UPLC-MS. Serum biochemical indicators and histopathological methods werae used to identify the status of SGD in treating liver injury. Read More

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http://dx.doi.org/10.1002/bmc.4940DOI Listing

Clinical Practice of Adalimumab and Infliximab Biosimilar Treatment in Adult Patients With Crohn's Disease.

Inflamm Bowel Dis 2020 Jul 7. Epub 2020 Jul 7.

IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy.

The introduction of tumor necrosis factor (TNF) inhibitors has significantly changed the treatment landscape in Crohn's disease (CD). The overall therapeutic achievements with TNF inhibitors such as infliximab, adalimumab, and certolizumab pegol paved the way to push the boundaries of treatment goals beyond symptomatic relief and toward cessation of objective signs of inflammation, including endoscopic remission. Even though these agents are widely used for the treatment of moderate to severe CD, heterogeneity still exists in translating evidence-based guidelines on the use of anti-TNF agents into actual treatment algorithms in CD. Read More

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http://dx.doi.org/10.1093/ibd/izaa078DOI Listing

Proximal renal tubular function in HIV-infected children on tenofovir disoproxil fumarate for treatment of HIV infection at two tertiary hospitals in Harare, Zimbabwe.

PLoS One 2020 7;15(7):e0235759. Epub 2020 Jul 7.

Department of Paediatrics, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.

Background: Renal abnormalities in HIV infected children may be due to the HIV infection or treatment among other factors. Tenofovir disoproxil fumarate (TDF) is associated with proximal renal tubular dysfunction, proteinuria and decrease in glomerular function. Studies in developed countries have shown variable prevalence of proximal renal tubular dysfunction in children on TDF. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235759PLOS

Effects of different separation methods on the physical and functional properties of extracellular vesicles.

PLoS One 2020 7;15(7):e0235793. Epub 2020 Jul 7.

Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea.

Extracellular vesicles (EVs) are small vesicles secreted from cells. They have crucial biological functions in intercellular communications and may even be biomarkers for cancer. The various methods used to isolate EVs from body fluid and cell culture supernatant have been compared in prior studies, which determined that the component yield and physical properties of isolated EVs depend largely on the isolation method used. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235793PLOS

LIN28B promotes the development of neuroendocrine prostate cancer.

J Clin Invest 2020 Jul 7. Epub 2020 Jul 7.

Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.

Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can develop when prostate adenocarcinoma cells acquire cancer stem-like cell signaling in the presence of androgen receptor inhibition, followed by re-differentiation toward neuroendocrine lineage and subsequent t-NEPC progression. Whether the stem-like signaling is controlled by the core pluripotency stem cell genes (e. Read More

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http://dx.doi.org/10.1172/JCI135373DOI Listing

Evaluation of Potential Antigen-specific Host Biomarkers in QuantiFERON Supernatants as Candidates for the Diagnosis of Ocular Tuberculosis.

Ocul Immunol Inflamm 2020 Jul 7:1-9. Epub 2020 Jul 7.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University , Cape Town, South Africa.

Purpose: To evaluate potential host biomarkers detectable in QuantiFERON supernatants as diagnostic candidates for ocular tuberculosis (OTB).

Methods: We investigated 47 host markers in QuantiFERON supernatants from 92 individuals with uveitis using the Luminex platform. We evaluated the potential of individual and combined biomarkers to distinguish between patients with possible, probable, and no OTB. Read More

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http://dx.doi.org/10.1080/09273948.2020.1763404DOI Listing

Bioinformatics analysis of high-throughput data to validate potential novel biomarkers and small molecule drugs for glioblastoma multiforme.

J Int Med Res 2020 Jul;48(7):300060520924541

The First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou, P. R. China.

Objective: There have been no recent improvements in the glioblastoma multiforme (GBM) outcome, with median survival remaining 15 months. Consequently, the need to identify novel biomarkers for GBM diagnosis and prognosis, and to develop targeted therapies is high. This study aimed to establish biomarkers for GBM pathogenesis and prognosis. Read More

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http://dx.doi.org/10.1177/0300060520924541DOI Listing

Identification of hub genes involved in apparent metabolizable energy of chickens.

Anim Biotechnol 2020 Jul 7:1-8. Epub 2020 Jul 7.

Department of Animal Sciences, Faculty of Agriculture, University of Guilan, Rasht, Iran.

Feed efficiency is one of the most economically significant traits in a breeding program. Apparent metabolizable energy is the most used method to evaluate energy utilization for feed efficiency. The purpose of this study was to identify candidate genes of chickens with divergent apparent metabolizable energy by bioinformatics analysis. Read More

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http://dx.doi.org/10.1080/10495398.2020.1784187DOI Listing

Differential biomarker profiles between unprovoked venous thromboembolism and cancer.

Ann Med 2020 Jul 7:1-26. Epub 2020 Jul 7.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville, Spain.

Background: The relationship between cancer and venous thromboembolic disease (VTD) are complex because the activated coagulation factors are not only involved in thrombosis, but also in malignant processes, such as angiogenesis and metastasis.

Objective: To compare phenotypes of extracellular vesicles (EVs), and levels of D-dimer, soluble P-selectin (sP-selectin) and antigenic tissue factor (TF) between unprovoked VTD patients, who did not develop cancer during one year follow-up, and those with advanced stage of cancer but not associated with VTD.

Methods: A prospective study in which we included 138 unprovoked VTD patients and 67 advanced cancer patients, who did not develop thrombosis. Read More

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http://dx.doi.org/10.1080/07853890.2020.1779956DOI Listing

LC-MS/MS Coupled with a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- and Oxidative Stress-Exposed Cells.

Chem Res Toxicol 2020 Jul 7. Epub 2020 Jul 7.

Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

Formaldehyde (FA) is a human carcinogen that is ubiquitous in the ambient environment and also generated endogenously in oxidatively stressed cells. There is accumulated evidence that FA is an etiological agent of leukemia development in humans. To develop a biomarker for FA exposure, we have, in this study, developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with stable isotope-dilution method to explore the reactivity of FA with glutathione (GSH) in physiologically relevant conditions. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.0c00170DOI Listing

Exhaled breath analysis using on-line preconcentration mass spectrometry for gastric cancer diagnosis.

J Mass Spectrom 2020 Jun 11:e4588. Epub 2020 Jun 11.

Institute of Mass Spectrometry and Atmospheric Environment, Jinan University, Guangzhou, China.

Breath volatile biomarkers are capable of distinguishing patients with various cancers. However, high throughput analytical technology is a prerequisite to a large-cohort study intended to discover reliable breath biomarkers for cancer diagnosis. Single-photon ionization (SPI) is a universal ionization technology, and SPI-mass spectrometry (SPI-MS) shows a remarkable advantage in the comprehensive detection of volatile organic compounds (VOCs), in particular, nonpolar compounds. Read More

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http://dx.doi.org/10.1002/jms.4588DOI Listing

COVID-19 pandemic: A challenge to a child with cancer.

Pediatr Blood Cancer 2020 Jul 7:e28512. Epub 2020 Jul 7.

Urinary Biomarkers Research Centre, Department of Urology, KLES Dr Prabhakar Kore Hospital & Medical Research Centre, Belagavi, Karnataka, India.

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http://dx.doi.org/10.1002/pbc.28512DOI Listing

Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro.

Food Funct 2020 Jul 7. Epub 2020 Jul 7.

Department of Food Science and Technology, Texas A&M University, College Station, TX, USA.

Cheese whey contains bioactive compounds which have shown multiple health-promoting benefits. This study aimed to assess the commercial whey products (CWP) whey protein isolate (WPI), galacto-oligosaccharide-whey protein concentrate (GOS-W) and glycomacropeptide (GMP) for their potential to improve intestinal health in vitro using HT29-MTX intestinal goblet and Caco-2 epithelial cells. Results from HT29-MTX culture showed that WPI mitigated reactive oxygen species (ROS) production at a higher extent compared to GOS-W or GMP. Read More

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http://dx.doi.org/10.1039/d0fo00487aDOI Listing

Anti-stress effects of polyphenols: animal models and human trials.

Food Funct 2020 Jul 7. Epub 2020 Jul 7.

School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Polyphenols, a category of plant compounds that contain multiple phenol structural units, are widely distributed throughout the plant kingdom and have multiple benefits for human health including anti-obesity, anti-hyperglycemic, and anti-hyperlipidemic effects. Additionally, polyphenols have recently gained attention for their anti-stress effects. In this review article, we summarize physiological responses against exposure to stressors and discuss biomarkers for exposure to stressors that are widely used in animal studies and human trials. Read More

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http://dx.doi.org/10.1039/d0fo01129kDOI Listing

Evaluation of 10 Urinary Biomarkers for Renal Safety With 5 Nephrotoxicants in Nonhuman Primates.

Toxicol Pathol 2020 Jul;48(5):633-648

Department of Safety Assessment and Laboratory Animal Resources, Merck & Co, Inc, West Point, PA, USA.

To date, there has been very little published data evaluating the performance of novel urinary kidney biomarkers in nonhuman primates (NHPs). To assess the biomarker performance and characterize the corresponding histomorphologic patterns of tubular renal injury in the NHP, several studies were conducted using mechanistically diverse nephrotoxicants including cefpirome, cisplatin, naproxen, cyclosporine, and a combination of gentamicin with everninomicin. An evaluation of 10 urinary biomarkers (albumin, clusterin, cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver-type fatty acid-binding protein, N-acetyl-β-D-glucosaminidase, osteopontin, retinol binding protein 4 and total protein) was performed on urine collected from these studies. Read More

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http://dx.doi.org/10.1177/0192623320932159DOI Listing

Correlation between carotid atherosclerotic plaque properties and serum levels of lncRNA CCAT2 and miRNA-216b.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):7033-7038

Department of Vascular Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: The purpose of this study was to uncover the clinical values of serum long non-coding RNA (lncRNA) CCAT2 and miRNA-216b in the properties of carotid atherosclerotic plaques.

Patients And Methods: Patients with carotid atherosclerotic plaques were assigned into stable plaque group (n=60) and unstable plaque (n=75) group based on their examination results of cervical contrast-enhanced CT examination. Maximal plaque thickness (MAPT) and intima-media thickness (IMT) in each group were determined. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21696DOI Listing

Obstructive Sleep Apnea, oxidative stress, inflammation and endothelial dysfunction-An overview of predictive laboratory biomarkers.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6939-6948

Department of Surgical Sciences, Molecular Biology Service (MBS), University of Cagliari, Cagliari, Italy.

Objective: Obstructive Sleep Apnea (OSA) represents an emerging public health concern with great impact on cardiovascular state. Oxidative stress (OS), inflammation and altered Nitric Oxide (NO) production are recognized as prominent mechanisms of many acute and chronic diseases and even of the normal aging process. They are investigated as major pathophysiological processes in OSA through the analysis and comparison of significative and validated biomarkers. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21685DOI Listing

Predicting microRNA-disease associations from lncRNA-microRNA interactions via Multiview Multitask Learning.

Brief Bioinform 2020 Jul 7. Epub 2020 Jul 7.

City University of Hong Kong.

Motivation: Identifying microRNAs that are associated with different diseases as biomarkers is a problem of great medical significance. Existing computational methods for uncovering such microRNA-diseases associations (MDAs) are mostly developed under the assumption that similar microRNAs tend to associate with similar diseases. Since such an assumption is not always valid, these methods may not always be applicable to all kinds of MDAs. Read More

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http://dx.doi.org/10.1093/bib/bbaa133DOI Listing

Crosstalk between circulating microRNAs and chronotypical features in subjects with metabolic syndrome.

Chronobiol Int 2020 Jul 7:1-11. Epub 2020 Jul 7.

Department of Nutrition, Food Science and Physiology; Center for Nutrition Research, University of Navarra , Pamplona, Spain.

Circulating microRNAs (miRNAs) are valuable biomarkers that may provide important insight into the pathogenesis of metabolic syndrome (MetS). Moreover, there is an association between chronotypical characteristics and MetS predisposition. Considering that expression of some miRNAs is circadian-rhythm-dependent, the aim of this study was to investigate the circulating miRNA profile in subjects with and without MetS in association with chronotype. Read More

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http://dx.doi.org/10.1080/07420528.2020.1782419DOI Listing

Pulsed magnetic field treatment ameliorates the progression of peripheral neuropathy by modulating the neuronal oxidative stress, apoptosis and angiogenesis in a rat model of experimental diabetes.

Arch Physiol Biochem 2020 Jul 7:1-8. Epub 2020 Jul 7.

Department of Medical Biology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.

: The present study aimed to investigate the possible anti-neuropathic effects of daily pulsed magnetic field treatments (PMF) in streptozotocin (60 mg/kg) induced 4 weeks diabetic (type-1) wistar rats (6-8 months).: Body mass, blood glucose and thermal and mechanical sensations were evaluated during the PMF or sham-PMF in diabetic or non-diabetic rats (n = 7/group). After the measurements of motor nerve conduction velocities (MNCV), the levels of several biomarkers for oxidative stress, apoptosis and angiogenesis in spinal cord and sciatic nerve were measured. Read More

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http://dx.doi.org/10.1080/13813455.2020.1788098DOI Listing

New-Onset Alzheimer's Disease and Normal Subjects 100% Separated Statistically by P300 and ICA.

Am J Alzheimers Dis Other Demen 2020 Jan-Dec;35:1533317520935675

Neuroptics Med Clinic, Bucharest, Romania.

Previously, we described how patients with new-onset Alzheimer's disease were differentiated from healthy, normal subjects to 100% accuracy, based on the amplitudes of the nonrhythmic back-projected independent components of the P300 peak at the electroencephalogram electrodes and their latency in the response to an oddball, auditory evoked potential paradigm. A neural network and a voting strategy were used for classification. Here, we consider instead the statistical distribution functions of their latencies and amplitudes and suggest that the 2-sample Kolmogorov-Smirnov test based upon their latency distribution functions offers an alternative biomarker for AD, with their amplitude distribution at the frontal electrode fp2 as possibly another. Read More

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http://dx.doi.org/10.1177/1533317520935675DOI Listing

Single-Particle Mobility Analysis Enables Ratiometric Detection of Cancer Markers under Darkfield Tracking Microscopy.

Anal Chem 2020 Jul 6. Epub 2020 Jul 6.

Here we introduced a single-particle mobility analysis based ratiometric strategy for quantitative detection of disease-related biomarkers using antibody-conjugated gold nanoparticles (AuNPs) as probes under darkfield tracking microscopy (DFTM). Based on the capability of discriminating nanoparticles with different hydrodynamic sizes and detecting the changes in hydrodynamic effect, single-particle mobility analysis enables us to determine the amount of aggregated and monodispersed nanoprobes for the sandwich-like immunoassay strategy, making it possible to quantify the biotargets by analyzing the relative changes in aggregate-to-monomer ratio of nanoprobes. By using capture antibody and detection antibody conjugated AuNPs as nanoprobes, we demonstrated ratiometric detection of carcinoembryonic antigen (CEA) over a linear dynamic range from 50 pM to 750 pM, which is competent for clinic diagnostic analysis of CEA in tumor patients. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b05512DOI Listing

Multi-biomarker strategy for prediction of myocardial dysfunction and mortality in sepsis.

J Zhejiang Univ Sci B 2020 Jul;21(7):537-548

Intensive Care Unit, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Objective: The present study was to evaluate the feasibility of using the multi-biomarker strategy for the prediction of sepsis-induced myocardial dysfunction (SIMD) and mortality in septic patients.

Methods: Brain natriuretic peptide (BNP), cardiac troponin I (cTnI), and heart-type fatty acid-binding protein (h-FABP) in 147 septic patients were assayed within 6 h after admission. We also determined the plasma levels of myeloperoxidase (MPO) and pregnancy-associated plasma protein-A (PAPP-A). Read More

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http://dx.doi.org/10.1631/jzus.B2000049DOI Listing

has_circ_CCNB1 and has_circ_0009024 function as potential biomarkers for the diagnosis of type 2 diabetes mellitus.

J Clin Lab Anal 2020 Jul 6:e23439. Epub 2020 Jul 6.

Department of Endocrinology, School of Medicine, Geriatric Research Center, Jinling Hospital, Nanjing University, Nanjing, China.

Circular RNAs (circRNAs) have been reported to be associated with various diseases, including type 2 diabetes mellitus (T2DM). The aim of present study was to investigate the clinical value of has_circ_CCNB1 and has_circ_0009024 in T2DM. Serum samples from patients with T2DM (n = 166) and healthy volunteers (n = 166) were recruited. Read More

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http://dx.doi.org/10.1002/jcla.23439DOI Listing

Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia.

Biol Cell 2020 Jul 6. Epub 2020 Jul 6.

Institute of Molecular Pathology Biomarkers, University of Extremadura, Caceres, Spain.

Background Information: Pancreatic stellate cells play a key role in the fibrosis that develops in diseases such as pancreatic cancer. In the growing tumor, a hypoxia condition develops under which cancer cells are able to proliferate. The growth of fibrotic tissue contributes to hypoxia. Read More

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http://dx.doi.org/10.1111/boc.202000020DOI Listing

Protein quality and safety evaluation of sarcoplasmic protein derived from silver carp (Hypophthalmichthys molitrix) using a rat model.

J Food Sci 2020 Jul 6. Epub 2020 Jul 6.

Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV, U.S.A.

Consisting of 25 to 30% of protein in carp, water-soluble sarcoplasmic proteins lost in wash water, have been recovered and freeze-dried into a protein-rich powder. Study objectives were to evaluate protein quality and safety of a silver carp sarcoplasm derived protein powder (CSP) compared to commercial protein supplements, casein, and whey. In vivo protein quality assessment of CSP showed a lower (P < 0. Read More

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http://dx.doi.org/10.1111/1750-3841.15321DOI Listing

The cerebral blood flow deficits in Parkinson's disease with mild cognitive impairment using arterial spin labeling MRI.

J Neural Transm (Vienna) 2020 Jul 6. Epub 2020 Jul 6.

Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey.

Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) is currently diagnosed based on an arbitrarily predefined standard deviation of neuropsychological test scores, and more objective biomarkers for PD-MCI diagnosis are needed. The purpose of this study was to define possible brain perfusion-based biomarkers of not only mild cognitive impairment, but also risky gene carriers in PD using arterial spin labeling magnetic resonance imaging (ASL-MRI). Fifteen healthy controls (HC), 26 cognitively normal PD (PD-CN), and 27 PD-MCI subjects participated in this study. Read More

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http://dx.doi.org/10.1007/s00702-020-02227-6DOI Listing

Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.

Endocr Pathol 2020 Jul 6. Epub 2020 Jul 6.

i3S Instituto de Investigação e Inovação em Saúde, Porto, Portugal.

Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on growth patterns including thyroid neoplasms with predominantly papillary, follicular, solid, and spindle cell growth pattern, as well as neoplasms with distinct cytological characteristics. Read More

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http://dx.doi.org/10.1007/s12022-020-09638-xDOI Listing

Nuclear PDCD4 Expression Defines a Subset of Luminal B-Like Breast Cancers with Good Prognosis.

Horm Cancer 2020 Jul 6. Epub 2020 Jul 6.

Laboratory of Molecular Mechanisms of Carcinogenesis and Molecular Endocrinology, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina.

The hormone receptor-positive (estrogen and/or progesterone receptor (PR)-positive) and HER2-negative breast cancer (BC) subtype is a biologically heterogeneous entity that includes luminal A-like (LumA-like) and luminal B-like (LumB-like) subtypes. Decreased PR levels is a distinctive biological feature of LumB-like tumors. These tumors also show reduced sensitivity to endocrine therapies and poorer prognosis than LumA-like tumors. Read More

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http://dx.doi.org/10.1007/s12672-020-00392-4DOI Listing

AI-based investigation of molecular biomarkers of longevity.

Authors:
Ihor Kendiukhov

Biogerontology 2020 Jul 6. Epub 2020 Jul 6.

School of Business and Economics, Humboldt University of Berlin, Unter den Linden 6, 10099, Berlin, Germany.

In this paper, I build deep neural networks of various structures and hyperparameters in order to predict human chronological age based on open-access biochemical indicators and their specifications from the NHANES database. In total, 1152 neural networks are trained and tested. The algorithms are trained and tested on incomplete data: missing values in data records are extrapolated by mean or median values for each parameter. Read More

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http://dx.doi.org/10.1007/s10522-020-09890-yDOI Listing

Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study.

Neurol Sci 2020 Jul 6. Epub 2020 Jul 6.

Department of Radiology, Eye & ENT Hospital of Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

Purpose: To explore the alterations of spontaneous neuronal activity and functional connectivity pattern using fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) in patients with primary angle-closure glaucoma (PACG) and fALFF relationship with the glaucoma clinical indices.

Materials And Methods: Forty-two PACG patients and 21 normal controls were enrolled in this study. Resting-state functional magnetic resonance imaging was firstly analyzed by fALFF and brain regions with altered fALFF between groups were selected as seeds for the further FC analysis. Read More

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http://dx.doi.org/10.1007/s10072-020-04577-1DOI Listing

Administration of indigenous probiotics modulate high-fat diet-induced metabolic syndrome in Sprague Dawley rats.

Antonie Van Leeuwenhoek 2020 Jul 6. Epub 2020 Jul 6.

Department of Microbiology, Basic Medical Sciences Block A, South Campus, Panjab University, Chandigarh, 160014, India.

Modulation of the gut microbiota by probiotics, is emerging as a promising approach for the management of metabolic diseases but due to their species and strain specific response, isolation of new probiotic strains is gaining importance. The present study was designed to assess the effect of isolated and well characterised indigenous probiotics, Lactobacillus pentosus GSSK2, Lactobacillus fermentum PUM and Lactobacillus plantarum GS26A in high fat diet (HFD) induced metabolic syndrome. It was observed that though supplementation of all three probiotics for 12 weeks to Sprague Dawley rats fed with HFD, ameliorated the anthropometric parameters, but L. Read More

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http://dx.doi.org/10.1007/s10482-020-01445-yDOI Listing

Upregulation of miR-133a-3p in the Sciatic Nerve Contributes to Neuropathic Pain Development.

Mol Neurobiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

The micro (mi)RNAs expressed in the sciatic nerve of streptozotocin (STZ)-induced diabetic rats were evaluated in terms of their therapeutic potential in patients with diabetic neuropathic pain (DNP). Relative miRNA expression in sciatic nerve with DNP was analyzed using next-generation sequencing and quantitative PCR. Potential downstream targets of miRNAs were predicted using Ingenuity Pathway Analysis and the TargetScan database. Read More

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http://dx.doi.org/10.1007/s12035-020-01999-yDOI Listing

Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients.

Breast Cancer Res Treat 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, Division of Clinical Pharmacology, Western University, London, ON, Canada.

Purpose: Female patients with breast cancer frequently develop arthralgia when treated with aromatase inhibitors (AI). Although the mechanism of AI-induced arthralgia is unknown, potential biomarkers have been identified. The purpose of this study was to investigate the clinical and genetic predictors of AI-induced arthralgia in a prospective cohort of patients with estrogen receptor-positive breast cancer. Read More

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http://dx.doi.org/10.1007/s10549-020-05777-1DOI Listing

Dietary phytoestrogens and biomarkers of their intake in relation to cancer survival and recurrence: a comprehensive systematic review with meta-analysis.

Nutr Rev 2020 Jul 6. Epub 2020 Jul 6.

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

Context: Recent studies have outlined the potential role of dietary factors in patients who have survived cancer.

Objective: The aim of this study was to summarize the evidence of the relation between dietary intake of phytoestrogens and their blood biomarkers and, overall, cancer-specific mortality and recurrence in patients with cancer.

Data Sources: A systematic search of PubMed, EMBASE, and Web of Science databases of studies published up to September 2019 was performed. Read More

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http://dx.doi.org/10.1093/nutrit/nuaa043DOI Listing
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