777,483 results match your criteria Biomarkers : biochemical indicators of exposure response and susceptibility to chemicals[Journal]


Non-invasive imaging methodologies for assessment of radiation damage to bone marrow and kidneys from peptide receptor radionuclide therapy.

Neuroendocrinology 2019 Apr 19. Epub 2019 Apr 19.


Background/Aims: Peptide receptor radionuclide therapy (PRRT) is becoming clinical routine for management of Neuroendocrine Tumours. The number of PRRT cycles are correlated with treatment effect but theoretically limited by off-target radiation damage to kidneys and bone marrow. New imaging biomarkers for assessment of PRRT tissue damage would enable evaluation of novel renal and bone marrow protective agents, as well as personalized PRRT treatment regiments. Read More

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http://dx.doi.org/10.1159/000500473DOI Listing

Dietary inflammatory index is positively associated with serum high-sensitivity C-reactive protein in a Korean adult population.

Nutrition 2018 Nov 23;63-64:155-161. Epub 2018 Nov 23.

Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA; Connecting Health Innovations LLC, Columbia, South Carolina, USA.

Objective: To our knowledge, only a few studies have explored the relationship between the inflammatory potential of diet and serum inflammatory markers in Korean adults. The likely novel aim of this study was to examine the association between the dietary inflammatory index (DII) and serum high-sensitivity C-reactive protein (hs-CRP) in a Korean adult population.

Methods: A cross-sectional study was conducted using the data set from the Korea National Health and Nutrition Examination Survey (KNHANES) 2015. Read More

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http://dx.doi.org/10.1016/j.nut.2018.11.016DOI Listing
November 2018

Lysophospholipid profiles of apolipoprotein E-deficient mice reveal potential lipid biomarkers associated with atherosclerosis progression using validated UPLC-QTRAP-MS/MS-based lipidomics approach.

J Pharm Biomed Anal 2019 Apr 5;171:148-157. Epub 2019 Apr 5.

Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Lysophospholipids (Lyso-PLs) are lipid-derived signaling molecules which were demonstrated to have a strong correlation with the progression of atherosclerosis. In this study, we investigated the influence of high-fat diet on Lyso-PL profiles of atherosclerosis-prone apolipoprotein E-deficient (ApoE) mice and wild type C57BL/6 J mice to find out the potential biomarkers associated with atherosclerosis. Firstly, the quantitative profiling method for Lyso-PLs based on ultra-performance liquid chromatography-quadrupole linear ion trap mass spectrometry (UPLC-QTRAP-MS/MS) was established and validated. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.062DOI Listing

Identification and expression of microRNAs in european eels Anguilla anguilla from two natural sites with different pollution levels.

Environ Pollut 2019 Apr 11;250:274-283. Epub 2019 Apr 11.

Univ. Bordeaux, UMR EPOC CNRS 5805, 33615, Pessac, France.

MicroRNAs (miRNAs) are a class of small non-coding RNA that control multiple biological processes through negative post-transcriptional regulation of gene expression. Recently a role of miRNAs in the response of aquatic organisms to environmental toxicants emerged. Toxicant-induced changes in miRNA expression might then represent novel biomarkers to evaluate the health status of these organisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183507
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http://dx.doi.org/10.1016/j.envpol.2019.04.029DOI Listing
April 2019
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Association between methylation of DNA damage response-related genes and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride.

Chemosphere 2019 Apr 9;227:323-328. Epub 2019 Apr 9.

Department of Statistics, School of Public Health, Shanxi Medical University, Taiyuan, China.

In the present study, we investigated the association between methylation of DNA damage response-related genes such as cyclin-dependent kinase inhibitor (CDKN)2A, Ras association (RalGDS/AF-6) domain family member (RASSF)1A, O6-methylguanine DNA methyltransferase (MGMT), Kirsten rat sarcoma viral oncogene homolog (KRAS), and spleen-associated tyrosine kinase (SYK) and DNA damage in hepatocytes of rats following subchronic exposure to vinyl chloride (VC). Sixty-four healthy rats were randomly divided into three VC exposure groups (5, 25, and 125 mg/kg) and an untreated negative control group (n = 16 each). VC was administered by intraperitoneal injection every other day for a total of three times a week. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.058DOI Listing

Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test.

Arch Gerontol Geriatr 2019 Apr 1;83:114-120. Epub 2019 Apr 1.

Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Spain.

Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674943193008
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http://dx.doi.org/10.1016/j.archger.2019.03.025DOI Listing
April 2019
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Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing

The effect of blueberry interventions on cognitive performance and mood: a systematic review of randomized controlled trials.

Brain Behav Immun 2019 Apr 15. Epub 2019 Apr 15.

IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Victoria, 3216, Australia. Electronic address:

Blueberries are rich in polyphenols that may be beneficial to cognitive performance and mood. The aim of this systematic review was to evaluate randomized controlled trials investigating the effects of blueberries and blueberry products on measures of cognition and mood. In total, eleven articles (that included 12 studies) were identified using freeze-dried blueberries (n=9 studies), whole blueberries (n=2) and blueberry concentrate (n=1). Read More

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http://dx.doi.org/10.1016/j.bbi.2019.04.001DOI Listing

Evaluation of the schistosomicidal, antioxidant and anti-inflammatory activities of the ethyl acetate fraction from Ozoroa pulcherrima Schweinf. Roots on Schistosoma mansoni-induced liver pathology in mice and its phytochemical characterization.

J Ethnopharmacol 2019 Apr 15:111883. Epub 2019 Apr 15.

Laboratory of Biology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon; Centre for Schistosomiasis and Parasitology, P.O. Box 7244, Yaoundé, Cameroon. Electronic address:

Ethnopharmacological Relevance: Ozoroa pulcherrima Schweinf. (syn.: Heeria pulcherrrima Schweinf. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111883DOI Listing

Anti-obesity effect of argel (Solenostemma argel) on obese rats fed a high fat diet.

J Ethnopharmacol 2019 Apr 15:111893. Epub 2019 Apr 15.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt. Electronic address:

Ethnopharmacological Relevance: Solenostemma argel (Argel) is a desert plant commonly used in Egyptian and Sudanese traditional medicine to suppress appetite, for treatment of diabetes, and as antispasmodic and anti-inflammatory agents. Previously the anti-diabetic, hypolipidemic and lipase inhibitory activities of Argel were reported in animal studies and in-vitro assays. However, its specific mechanism of action as an anti-obesity agent has not been studied before. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183492
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http://dx.doi.org/10.1016/j.jep.2019.111893DOI Listing
April 2019
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Differential Expression of HMGA1 and HMGA2 in pituitary neuroendocrine tumors.

Mol Cell Endocrinol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Endocrinology - LEEx, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Graduate Program in Endocrinology, Faculty of Medicine, Federal University of Rio de Janeiro, Brazil; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil. Electronic address:

Defining biomarkers for invasive pituitary neuroendocrine tumors (PitNETs) is highly desirable. The high mobility group A (HMGA) proteins are among the most widely expressed cancer-associated proteins. Indeed, their overexpression is a frequent feature of human malignancies, including PitNETs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03037207193011
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http://dx.doi.org/10.1016/j.mce.2019.04.010DOI Listing
April 2019
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IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
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http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
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Prediction and perception: insights for (and from) tinnitus.

Neurosci Biobehav Rev 2019 Apr 15. Epub 2019 Apr 15.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX 75080, USA; Global Brain Health Institute, Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

More than 150 years have passed since Helmholtz first described perception as a process of unconscious inference about the causes of sensations. His ideas have since inspired a wealth of literature investigating the mechanisms underlying these inferences. In recent years, much of this work has converged on the notion that the brain is a hierarchical generative model of its environment that predicts sensations and updates itself based on prediction errors. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.04.008DOI Listing

Omega-3 fatty acids protects against chronic sleep-deprivation induced memory impairment.

Life Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Aims: The current study aims to evaluate the possible protective effect of omega-3 fatty acids on memory impairment induced by sleep-deprivation in rats.

Materials And Methods: Animals were chronically sleep deprived using the modified multiple platform model (8 h/day for 8 weeks). Omega-3 fatty acids were administered as fish oil via oral gavage at a daily dose of 100 mg omega-3 PUFA/100 g BWT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205193028
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http://dx.doi.org/10.1016/j.lfs.2019.04.028DOI Listing
April 2019
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Differential diagnosis between Alzheimer's disease and other dementias: Role of cerebrospinal fluid biomarkers.

Clin Biochem 2019 Apr 15. Epub 2019 Apr 15.

Centre for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.011DOI Listing

The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation.

JAMA Facial Plast Surg 2019 Apr 18. Epub 2019 Apr 18.

Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Acute rejection is one of the most frequent complications in facial transplantation, with potentially severe consequences for the recipient if overlooked. Clinical signs, such as erythema or edema, are helpful to diagnose acute rejection in the early follow-up stage; however, it is not well known whether these clinical signs remain reliable markers of acute rejection beyond the second posttransplant year.

Objective: To determine the diagnostic value of clinical signs of acute rejection after facial transplantation over time. Read More

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http://archfaci.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamafacial.2019.0076DOI Listing
April 2019
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Concerns Regarding Phase 1b Clinical Trial of Atezolizumab Plus Nab-Paclitaxel for Metastatic Breast Cancer-In Reply.

JAMA Oncol 2019 Apr 18. Epub 2019 Apr 18.

Oncology Biomarkers Development, Genentech Inc, South San Francisco, California.

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http://dx.doi.org/10.1001/jamaoncol.2019.0317DOI Listing

Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.

Shock 2019 Apr 12. Epub 2019 Apr 12.

Department of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.

Background: A declining selenium (Se) status constitutes a characteristic of critical illness and may affect disease course and survival. The dynamics of trauma-induced changes in biomarkers of Se status are poorly characterized, and an association with multiple organ failure (MOF) and mortality can be hypothesized. It was the aim of this study to investigate Se and selenoprotein P (SELENOP) concentrations in major trauma patients during the early posttraumatic period. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001344DOI Listing

Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Objectives: To determine whether circulating endothelial cells from septic shock patients and from nonseptic shock patients are transformed in activated fibroblast by changing the expression level of endothelial and fibrotic proteins, whether the level of the protein expression change is associated with the amount of administered resuscitation fluid, and whether this circulating endothelial cell protein expression change is a biomarker to predict sepsis survival.

Design: Prospective study.

Setting: Medical-surgical ICUs in a tertiary care hospital. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003778DOI Listing

Identification of noncoding RNA expression profiles and regulatory interaction networks following traumatic spinal cord injury by sequence analysis.

Aging (Albany NY) 2019 04 18. Epub 2019 Apr 18.

Jinan Central Hospital Affiliated to Shandong University, Jinan, China.

Aim: To systematically profile and characterize the noncoding RNA (ncRNA) expression pattern in the lesion epicenter of spinal tissues after traumatic spinal cord injury (TSCI) and predicted the structure and potential functions of the regulatory networks associated with these differentially expressed ncRNAs and mRNAs.

Results: A total of 498 circRNAs, 458 lncRNAs, 155 miRNAs and 1203 mRNAs were identified in TSCI mice models to be differentially expressed. The regulatory networks associated with these differentially expressed ncRNAs and mRNAs were constructed. Read More

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http://dx.doi.org/10.18632/aging.101919DOI Listing

Computational identification of RNA-Seq based miRNA-mediated prognostic modules in cancer.

IEEE J Biomed Health Inform 2019 Apr 16. Epub 2019 Apr 16.

Systematic identification of miRNA prognostic signature can help decipher the effects of biomarkers in cancer treatment. A number of previous studies have only characterized a single miRNA as a promising prognostic biomarker. There is currently a trend towards combining several miRNAs as a panel of prognostic signatures, but few attempt to explain the mechanism of miRNA combination. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2911528DOI Listing

Plasma proteomics and the paediatric patient.

Expert Rev Proteomics 2019 Apr 18. Epub 2019 Apr 18.

a Haematology Research Laboratory, Murdoch Children's Research Institute , Melbourne Australia.

Introduction: Plasma proteomics has been utilised extensively for studies that investigate various disease settings (e.g. cardiovascular disease), as well as to monitor the effect of pharmaceuticals on the plasma proteome (e. Read More

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http://dx.doi.org/10.1080/14789450.2019.1608186DOI Listing

Determination of thresholds values for platelet serotonin and urinary 5-HIAA concentrations for the biological diagnosis of digestive neuroendocrine tumors.

Ann Biol Clin (Paris) 2019 Apr;77(2):161-168

Laboratoire de biochimie et biologie moléculaire, CHRU de Tours, France, UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Objectives: Platelet serotonin and its urinary metabolite 5-HIAA (5-hydroxyindolacetic acid) are the main biomarkers measured for the detection of neuroendocrine tumors (NET). We observe in our laboratory many false positives or false negatives for the 2 assays using threshold values given by the manufacturer. We aim to determine our own local threshold values for a better detection of gastrointestinal NETs. Read More

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http://dx.doi.org/10.1684/abc.2019.1432DOI Listing

Non-invasive biomarkers of fibrosis for the screening of patients with metabolic steatopathy (NAFLD) : a significant role for all biologists.

Ann Biol Clin (Paris) 2019 Apr;77(2):125-127

Université Paris Diderot, UFR de médecine Xavier Bichat, Université Paris-Diderot, Centre de recherche sur l'inflammation (CRI), UMR 1149 et DHU Unity, Paris, France, Service d'hépatologie, Hôpital Beaujon, AP-HP, Clichy, France.

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http://dx.doi.org/10.1684/abc.2019.1428DOI Listing

[Significance of Detecting Serum Complement C3 and C4 in Patients with Multiple Myeloma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):472-476

Department of Hematology, Chaohu Hospital Affiliated to Anhui Medical University,Chaohu 238000, Anhui Province, China.

Objective: To investigate the significance of detecting serum complement C3 and C4 in patients with multiple myeloma (MM) and to explore its correlation with myeloma bone disease (MBD).

Methods: The levels of serum complement C3 and C4 in 69 MM patients and 30 healthy people were examined by scatter nephelometry. The bone density of L1-4 vertebral body, bilateral femoral neck and bilateral hip joints were measured by dual energy bone density meter (DXA). Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.026DOI Listing

[Analysis of Unfavorable Prognosis Gene Markers in Patients with Acute Myeloid Leukemia by Multiomics].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):331-338

School of Management, Shanxi Medical University, Taiyuan 030001, Shanxi Province,China,E-mail:

Objective: To analyze the molecular markers associated with occurrence, development and poor prognosis of acute myeloid leukemia (AML) by using the data of GEO and TCGA database, as well as multiomics analysis.

Methods: The transcriptome data meeting requirements were down-loaded from GEO database, the differentially expressed genes were screened by using the R language limma package, and the GO function enrichment analysis and KEGG pathway analysis were performed for differentially expressed genes, at the same time, the protein interaction network was contracted by using STRING database and cytoscape software to screen out the hub gene, then the prognosis analysis was carried out for hub gene by combination with the clinical information affected in TCGA database.

Results: 620 differentially expressed genes were screened out, among which 162 differentially expressed genes were up-regulated, and 458 differentially expressed genes were down-regulated. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.004DOI Listing

Perspectives on gender parity in bioanalysis: an interview with Lauren Stevenson.

Bioanalysis 2019 Apr 18. Epub 2019 Apr 18.

Development Biomarkers and Bioanalytical Sciences, Biogen, Cambridge, MA 02142, USA.

Biography Lauren is Senior Director, Development Biomarkers & Bioanalytical Sciences at Biogen, Cambridge, MA, USA where she leads a team of talented scientists, setting bioanalytical and biomarker strategies and developing pharmacokinetics (PK), immunogenicity and biomarker assays in support of programs at all stages of development, from discovery to post-marketing. Lauren's team currently supports over 40 therapeutic programs, delivering PK and immunogenicity strategy and execution for Biogen's large molecule, antisense oligonucleotide (ASO0 and gene therapy portfolio as well as developing biomarkers in support of multiple sclerosis, immunology, fibrosis, rare and neurodegenerative disease indications. Externally, Lauren engages the broader industry and regulatory agencies as an invited speaker and course instructor at multiple conferences and workshops each year. Read More

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https://www.future-science.com/doi/10.4155/bio-2019-0060
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http://dx.doi.org/10.4155/bio-2019-0060DOI Listing
April 2019
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Perspectives on gender parity in bioanalysis: an interview with Shane Needham.

Authors:
Shane Needham

Bioanalysis 2019 Apr 18. Epub 2019 Apr 18.

Alturas Analytics, Inc., 1324 Alturas Drive, Moscow, ID 83843, USA.

Dr Shane Needham received his BS degree in chemistry from Washington State University and his PhD in chemistry from the University of Rhode Island. Dr Needham is Co-Founder and Chief Scientific Officer of Alturas Analytics, Inc. Dr Needham manages all scientific aspects of the HPLC/MS/MS bioanalytical contract laboratory at Alturas Analytics, Inc. Read More

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https://www.future-science.com/doi/10.4155/bio-2019-0058
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http://dx.doi.org/10.4155/bio-2019-0058DOI Listing
April 2019
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Perspectives on gender parity in Bioanalysis: an interview with Scott Summerfield.

Bioanalysis 2019 Apr 18. Epub 2019 Apr 18.

Department of Bioanalysis, Immunogenicity & Biomarkers, GlaxoSmithKline R&D, Park Road, Ware, SG12 0DP, UK.

Biography Having studied for a PhD and postdoctoral fellowship in proteomics Scott moved into the field of regulated Bioanalysis in 1997 when joining SmithKline Beecham. In 2001, Scott moved to Neuroscience Drug Discovery to lead a bioanalytical team supporting PK, DMPK and metabolite id work. In 2009, he returned to the regulated bioanalytical group, initially as a Section Leader and subsequently as Site Head and currently as WW Head of Bioanalysis at GSK. Read More

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https://www.future-science.com/doi/10.4155/bio-2019-0073
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http://dx.doi.org/10.4155/bio-2019-0073DOI Listing
April 2019
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Bioanalysis - but not as we knew it: an AstraZeneca perspective of the last 10 years evolution to meet a diversifying portfolio.

Bioanalysis 2019 Apr 18. Epub 2019 Apr 18.

Translational Biomarkers & Bioanalysis, Drug Safety & Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK.

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http://dx.doi.org/10.4155/bio-2019-0037DOI Listing

Prognostic Relevance of Tertiary Lymphoid Organs Following Neoadjuvant Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma.

Cancer Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Gastroenterological Surgery II, Hokkaido University, Faculty of Medicine.

The efficacy of preoperative neoadjuvant chemoradiotherapy (NAC) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs (TLOs) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. Read More

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http://dx.doi.org/10.1111/cas.14023DOI Listing

A novel microRNA signature predicts vascular invasion in hepatocellular carcinoma.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Vascular invasion (VI) in hepatocellular carcinoma (HCC) is an important clinical parameter to predict survival. In this study, we collected microRNA (miRNA) expression data from HCC patients using The Cancer Genome Atlas database and identified a novel miRNA signature associated with VI. First, we categorized HCC patients into groups with or without VI (VI+ and VI-). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28690
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http://dx.doi.org/10.1002/jcp.28690DOI Listing
April 2019
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Inflammatory biomarkers and frailty among older hospitalized patients: author's response.

Aging Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

National Clinical Research Center for Geriatrics, Chengdu, China.

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http://dx.doi.org/10.1007/s40520-019-01198-3DOI Listing

Altered miR-21, miRNA-148a Expression in Relation to KRAS Mutation Status as Indicator of Adenoma-Carcinoma Transitional Pattern in Colorectal Adenoma and Carcinoma Lesions.

Biochem Genet 2019 Apr 17. Epub 2019 Apr 17.

Colorectal Cancer Research Center and Department of Biochemistry, Shiraz University of Medical Sciences, P.O Box 1167, Shiraz, Iran.

Sporadic colorectal cancer (CRC) is a fatal disease, mostly known as the silent killer, due to the fact that this disease is asymptomatic before diagnosis in advanced stage. Screening and the early detection of CRC and colorectal adenoma (CRA) by non-aggressive molecular biomarkers' signature is useful for improvement of survival rate in CRC patients. To achieve such a goal, a better understanding of distinct molecular abnormalities as candidate biomarkers in CRC development is crucial. Read More

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http://dx.doi.org/10.1007/s10528-019-09918-0DOI Listing

Implementing a central composite design for the optimization of solid phase microextraction to establish the urinary volatomic expression: a first approach for breast cancer.

Metabolomics 2019 Apr 17;15(4):64. Epub 2019 Apr 17.

CQM-Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105, Funchal, Portugal.

Introduction: Breast cancer (BC) is positioned as the second among all cancers remaining at the top of women´s diseases worldwide followed by colorectum, lung, cervix, and thyroid cancers. The main drawback of most the screening/diagnostic methods is their low sensitivity/specificity and in some cases the invasive procedure required to obtain the samples.

Objectives: On the present investigation, we report a statistical design was to evaluate by central composite design the influence towards the optimization of the most significant variables of solid-phase microextraction (SPME) procedure for the isolation of volatile organic metabolites (VOMs) from urine of BC patients (N = 31) and healthy individuals (CTL; N = 40). Read More

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http://link.springer.com/10.1007/s11306-019-1525-2
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http://dx.doi.org/10.1007/s11306-019-1525-2DOI Listing
April 2019
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[Laboratory tests for kidney disease].

Authors:
G M Fiedler B Vogt

Internist (Berl) 2019 Apr 17. Epub 2019 Apr 17.

Universitätsklinik für Nephrologie und Hypertonie, Inselspital, Universitätsspital Bern, Universität Bern, 3010, Bern, Schweiz.

Kidney diseases are among the most frequently reported diseases with a poor prognosis that are diagnosed too late. According to current Kidney Disease Improving Global Outcomes (KDIGO) guidelines, diagnosis and risk stratification are mainly based on functional markers (creatinine and cystatin C), which are used to determine the estimated glomerular filtration rate (eGFR) and the analysis of urinary albumin excretion as a marker of kidney damage. These methods have limitations that can complicate the interpretation of the results and can lead to a delay of the diagnosis as well as to a misinterpretation of the prognosis. Read More

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http://dx.doi.org/10.1007/s00108-019-0598-3DOI Listing

Calcium isotope ratios in blood and urine: A new biomarker for the diagnosis of osteoporosis.

Bone Rep 2019 Jun 16;10:100200. Epub 2019 Mar 16.

Clinical Research Center Kiel GmbH, Schauenburgerstraße 116, 24118 Kiel, Germany.

We assessed the potential of Calcium (Ca) isotope fractionation measurements in blood (δCa) and urine (δCa) as a new biomarker for the diagnosis of osteoporosis. One hundred post-menopausal women aged 50 to 75 years underwent dual-energy X-ray absorptiometry (DXA), the gold standard for determination of bone mineral density. After exclusion of women with kidney failure and vitamin D deficiency (<25 nmol/l) 80 women remained in the study. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453776PMC
June 2019
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Care of acute conditions and chronic diseases in Canada and the United States: Rapid systematic review and meta-analysis.

J Public Health Res 2019 Mar 11;8(1):1479. Epub 2019 Mar 11.

School of Social Work.

This study tested the hypothesis that socioeconomically vulnerable Canadians with diverse acute conditions or chronic diseases have health care access and survival advantages over their counterparts in the USA. A rapid systematic review retrieved 25 studies (34 independent cohorts) published between 2003 and 2018. They were synthesized with a streamlined meta-analysis. Read More

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http://dx.doi.org/10.4081/jphr.2019.1479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444377PMC

LncRNA: An All-rounder in Rheumatoid Arthritis.

J Transl Int Med 2019 Mar 29;7(1):3-9. Epub 2019 Mar 29.

Division of Rheumatology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, Hangzhou, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. Read More

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http://content.sciendo.com/view/journals/jtim/7/1/article-p3
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http://dx.doi.org/10.2478/jtim-2019-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463828PMC
March 2019
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The ABCs of preventing hyperprogressive disease after immunotherapy: awareness, biomarkers, and combination.

Authors:
Kenichi Suda

J Thorac Dis 2019 Mar;11(Suppl 3):S347-S351

Division of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Japan.

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http://dx.doi.org/10.21037/jtd.2018.12.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424788PMC

The message from the matrix-should we listen more closely?

J Thorac Dis 2019 Mar;11(Suppl 3):S230-S233

Nordic Bioscience A/S, Herlev Hovedgade, Herlev, Denmark.

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http://dx.doi.org/10.21037/jtd.2019.01.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424747PMC

A novel behavioural INTErvention to REduce Sitting Time in older adults undergoing orthopaedic surgery (INTEREST): protocol for a randomised controlled feasibility study.

Pilot Feasibility Stud 2019 6;5:54. Epub 2019 Apr 6.

1School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT UK.

Background: Osteoarthritis is a highly prevalent condition in older adults, that causes many sufferers to require a hip or knee replacement in order to improve their quality of life and reduce pain. Individuals waiting for hip or knee replacements are often highly sedentary; thus, it is pertinent to assess whether reducing their sedentariness prior to surgery may aid in improving post-operative outcomes.

Methods/design: The study will be a randomised controlled feasibility trial design, with 2:1 randomisation into an intervention and usual care group respectively. Read More

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http://dx.doi.org/10.1186/s40814-019-0437-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451782PMC

Protective effects of resveratrol on biomarkers of oxidative stress, biochemical and histopathological changes induced by sub-chronic oral glyphosate-based herbicide in rats.

Toxicol Res (Camb) 2019 Mar 7;8(2):238-245. Epub 2019 Jan 7.

Department of Pharmacology and Toxicology , Faculty of Veterinary Medicine , University of Afyon Kocatepe , Afyonkarahisar , Turkey . Email: ; Email: ; ; Tel: +90272281312-2798.

The aim of this sub-chronic toxicity study is to determine the protective effects of Resveratrol (Res) on oxidative stress, biochemical and histopathological changes induced by glyphosate-based herbicide (GBH) in the blood, brain, heart, liver and renal tissues. A total of 28 male Wistar rats were equally divided into 4 groups so that each group included 7 rats. In the study, Group I (control group) was given normal rodent feed and tap water . Read More

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http://xlink.rsc.org/?DOI=C8TX00287H
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http://dx.doi.org/10.1039/c8tx00287hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417488PMC
March 2019
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Lanthanide nanoparticles for high sensitivity multiparameter single cell analysis.

Chem Sci 2019 Mar 23;10(10):2965-2974. Epub 2019 Jan 23.

Department of Chemistry , University of Toronto , 80 St George Street , Toronto , Ontario M5S 3H6 , Canada . Email: ; Email:

Mass cytometry (MC) is a high throughput multiparameter analytical technique for determining biomarker expression in cells. In MC, antibodies (Abs) are tagged with heavy metal isotopes conjugation to metal chelating polymers (MCPs). To improve the sensitivity of MC towards low abundance biomarkers, we are developing nanoparticle (NP)-based reagents as mass tags for Abs. Read More

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http://xlink.rsc.org/?DOI=C8SC04407D
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http://dx.doi.org/10.1039/c8sc04407dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427950PMC
March 2019
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Development of a glycoproteomic strategy to detect more aggressive prostate cancer using lectin-immunoassays for serum fucosylated PSA.

Clin Proteomics 2019 6;16:13. Epub 2019 Apr 6.

1Department of Pathology, Johns Hopkins Medicine, Smith Bldg 4013, 400 N. Broadway, Baltimore, MD 21287 USA.

Background: Prostate-specific antigen (PSA) is commonly used as a serum biomarker for the detection of prostate cancer. However, levels of PSA in serum do not reliably distinguish aggressive prostate cancer from non-aggressive disease. Therefore, there is an urgent need for biomarkers that can differentiate aggressive prostate cancers from non-aggressive phenotypes. Read More

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http://dx.doi.org/10.1186/s12014-019-9234-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451306PMC

A Six-Gene-Based Prognostic Model Predicts Survival in Head and Neck Squamous Cell Carcinoma Patients.

J Maxillofac Oral Surg 2019 Jun 24;18(2):320-327. Epub 2019 Jan 24.

3Department of Pathology, The University of Iowa, 500 Newton Road, #ML 1132, Iowa City, IA 52242-5000 USA.

Background And Objective: Head and neck cancer is a malignant tumor that begins in the head and neck region, and has the sixth highest incidence worldwide. Previous studies have indicated several prognostic markers for head and neck squamous cell carcinoma (HNSCC), but due to poor accuracy and sensitivity of these clinical characteristic markers attention has been gradually switched to molecular biomarkers. This study aimed to sort out the mRNAs correlated with patient survival time to establish an mRNA combination prognostic biomarker model for HNSCC patient risk stratification, providing optimal therapeutic regimens and improving patient prognosis. Read More

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http://dx.doi.org/10.1007/s12663-019-01187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441444PMC

Correlation Between Clinical Course and Biochemical Analysis in Odontogenic Space Infections.

J Maxillofac Oral Surg 2019 Jun 22;18(2):203-209. Epub 2018 Jun 22.

Department of Oral and Maxillofacial Surgery, Sri Guru Ram Das Institute of Dental Sciences and Research, Mall Mandi, Amritsar, Punjab 143006 India.

Objective: To correlate the clinical course and biochemical analysis in odontogenic space infections.

Methods: A randomized prospective study was undertaken in 50 patients presenting with infections of odontogenic origin. The data were subjected to statistical analysis to co-relate the values of CRP, WBC count and ESR with the clinical course of odontogenic infections. Read More

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http://link.springer.com/10.1007/s12663-018-1132-1
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http://dx.doi.org/10.1007/s12663-018-1132-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441441PMC
June 2019
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[Advances in epigenetic markers of dermatomyositis/polymyositis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):374-377

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. Read More

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April 2019
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[Early effects of low-level long-term occupational chromate exposure on workers'health].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):307-314

Department of Occupational and Environmental Health, Peking University School of Public Health, Beijing 100191, China.

Objective: To explore the effects of low-level long-term occupational exposure to chromate on the health of workers, and the potential biomarkers of early health effects in terms of lung function, immune toxicity and genetic damage.

Methods: A total of 22 chromate contact workers and 44 non-chromate contact workers from an electroplating enterprise with long-term occupational environment monitoring in line with the national standards in Inner Mongolia were investigated. The questionnaire survey was conducted to collect the basic situation, the history of smoking, drinking, diseases and so on. Read More

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