1,655 results match your criteria Biomarkers[Journal]


A systematic review and meta-analysis of higher expression of Folate receptor alpha (FOLR1) predicts poor cancer prognosis.

Biomarkers 2020 May 18:1-20. Epub 2020 May 18.

Department of Central Laboratory, the First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, China.

Folate Receptor Alpha (FOLR1), a glycosylphosphatidylinositol-linked protein, is well characterized folate transporters. However, the prognostic power of FOLR1 in cancer remains controversial. We conducted a meta-analysis to assess the prognostic roles of FOLR1 on different cancers. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1771420DOI Listing

F-Actin is Associated with a Worsening qSOFA Score and Intensive Care Unit Admission in Emergency Department Patients at Risk for Sepsis.

Biomarkers 2020 May 18:1-23. Epub 2020 May 18.

Department of Emergency Medicine, Henry Ford Hospital, Detroit, Michigan.

Objective: We previously demonstrated that plasma levels of F-actin and Thymosin Beta 4 differs among patients with septic shock, non-infectious systemic inflammatory syndrome and healthy controls and may serve as biomarkers for the diagnosis of sepsis. The current study aims to determine if these proteins are associated with or predictive of illness severity in patients at risk for sepsis in the Emergency Department (ED).

Methods: Prospective, biomarker study enrolling patients (>18 years) who met the Shock Precautions on Triage Sepsis rule placing them at-risk for sepsis. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1771419DOI Listing

Comparison of temporal changes in established cardiovascular biomarkers after acute coronary syndrome between Caucasian and Chinese patients with diabetes mellitus.

Biomarkers 2020 Jun 4;25(4):341-348. Epub 2020 May 4.

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.

Population means of conventional cardiovascular biomarkers are known to differ between ethnic groups. In this study we performed detailed comparisons in the temporal pattern of these biomarkers between Caucasian and Chinese diabetic patients with acute coronary syndrome (ACS). We studied differences in temporal changes of established cardiovascular biomarkers, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, cardiac Troponin T (TnT), NT-proBNP and C-reactive protein (CRP), in 48 Chinese and 48 clinically matched Caucasian patients with type 2 diabetes mellitus who were admitted for ACS. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1759692DOI Listing

Role of ascitic endocan levels in the diagnosis of spontaneous bacterial peritonitis in decompensated cirrhosis.

Biomarkers 2020 Jun 14;25(4):360-366. Epub 2020 May 14.

Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

To assess the role of ascitic endocan levels in the diagnosis of spontaneous bacterial peritonitis (SBP) in decompensated cirrhosis. Ascites samples, as well as demographic and laboratory data, were collected at admission from patients with decompensated cirrhosis. Ascitic endocan, tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels were measured by ELISA. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1764107DOI Listing

Application of the fourth universal definition of myocardial infarction in clinical practice.

Biomarkers 2020 Jun 14;25(4):322-330. Epub 2020 May 14.

Department of Medical Sciences, Uppsala University and Uppsala Clinical Research Center, Uppsala University, Sweden.

The Fourth Universal Definition of Myocardial Infarction (MI) has highlighted the different pathophysiological mechanisms that may lead to ischaemic and non-ischaemic myocardial injury and has emphasised that the diagnosis of myocardial infarction requires the presence of acute myocardial ischaemia in the setting of acute myocardial injury. This case based review intends to illustrate basic principles on how to apply this new, revised definition in clinical practice. The distinction between different types of MIs (type 1 or type 2) and the delineation of MI from acute non-ischaemic myocardial injury may be challenging in individual patients, which is illustrated by presenting and discussing real-life routine cases. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1764108DOI Listing

Management of peels for protection and treatment against gastric ulcer induced by ethanol in rats.

Biomarkers 2020 Jun 7;25(4):349-359. Epub 2020 May 7.

Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, Egypt.

Stomach ulcer is one of the most prevalent disorders worldwide. The study was aimed to isolate and characterize the major polymethoxylated flavonoids in peels petroleum ether extract and investigate its protective and curative effect on gastric ulcer. Some spectral analyses were used for identification of the isolated compounds from the petroleum ether extract of peels. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1759693DOI Listing
June 2020
2.522 Impact Factor

Biomarker dynamics in cardiac surgery: a prospective observational study on MR-proADM, MR-proANP, hs-CRP and sP-selectin plasma levels in the perioperative period.

Biomarkers 2020 May 17;25(3):296-304. Epub 2020 Apr 17.

Department of Cardiothoracic Surgery and Anesthesia, Linköping University, Linköping, Sweden.

For many biomarkers in cardiac surgery, there is a lack of knowledge regarding the normal dynamics of plasma levels during the perioperative course. The aim of this study was to investigate the perioperative dynamics of MR-proADM, MR-proANP, hs-CRP and sP-selectin in cardiac surgery. A prospective observational pilot study with 20 patients scheduled for open cardiac surgery procedures with cardiopulmonary bypass (CPB). Read More

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http://dx.doi.org/10.1080/1354750X.2020.1748716DOI Listing

Alterations of lymphocyte count and platelet volume precede cerebrovascular lesions in stroke-prone spontaneously hypertensive rats.

Biomarkers 2020 May 14;25(3):305-313. Epub 2020 Apr 14.

Department of Pharmacology, Faculty of Medicine, Kindai University, Osaka, Japan.

Cerebral small vessel disease (CSVD) is associated with future stroke. Although pathological alteration in small vessels of patients with CSVD can be detected by neuroimaging, diagnosis of CSVD is delayed because it is an asymptomatic disease. The stroke-prone spontaneously hypertensive rat (SHRSP) show similar pathological features to human CSVD and develop stroke-related symptoms with advancing age. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1750703DOI Listing

Analysis of gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.

Biomarkers 2020 Jun 30;25(4):331-340. Epub 2020 Apr 30.

Department of Biomedical Oncology Laboratory, National Institute of Respiratory Diseases, Mexico City, Mexico.

Ifosfamide (IFA) is an effective antineoplastic for solid tumours in children, although it is associated with high levels of systemic toxicity and causes death in some cases. The aim of this study was to determine whether the presence of certain allelic variants of genes , , and increases the risk of toxicity in children with solid tumours treated with ifosfamide. A total of 131 DNA samples were genotyped by real-time polymerase chain reaction (RT-PCR) using TaqMan probes. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1754913DOI Listing

Usefulness of F2-isoprostanes in early prognostication after cardiac arrest: a topical review of the literature and meta-analysis of preclinical data.

Biomarkers 2020 Jun 16;25(4):315-321. Epub 2020 Apr 16.

Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece.

Prognostication after cardiac arrest (CA) represents a challenging issue, and several biomarkers have been proposed in the attempt to predict outcome. Among these, F2-isoprostanes stand out as potential biomarkers for early prognostication, providing information on the magnitude of global oxidative injury after return of spontaneous circulation (ROSC). We performed a topical review searching PubMed and Scopus databases to identify studies evaluating the modifications of F2-isoprostanes in the early period after CA, and a meta-analysis of studies providing curves of F2-isoprostanes plasma levels seeking to describe the biomarker's kinetics after CA. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1754465DOI Listing
June 2020
2.522 Impact Factor

Expression of Concern.

Authors:

Biomarkers 2020 04 10. Epub 2020 Apr 10.

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http://dx.doi.org/10.1080/1354750X.2020.1751941DOI Listing

Expression of Concern.

Authors:

Biomarkers 2020 04 7. Epub 2020 Apr 7.

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http://dx.doi.org/10.1080/1354750X.2020.1751942DOI Listing

Expression of Concern.

Authors:

Biomarkers 2020 04 7. Epub 2020 Apr 7.

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http://dx.doi.org/10.1080/1354750X.2020.1751939DOI Listing

SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension.

Biomarkers 2020 May 5;25(3):290-295. Epub 2020 Apr 5.

Department of Cardiology and Angiology, University of Giessen, Giessen, Germany.

This study assessed the utility of SPARC-like protein 1 (SPARCL1) as a biomarker of maladaptive right ventricular (RV) function in patients with pulmonary hypertension (PH). In this prospective study, we examined SPARCL1 levels in 105 patients with adaptive ( = 34) and maladaptive RV ( = 32) pressure overload caused by PH, dilated cardiomyopathy (DCM,  = 18) with LVEF < 35% and preserved RV function and controls without LV or RV abnormalities ( = 21). The median SPARCL1 concentration in patients with maladaptive RV function was higher than in those with adaptive RV function ( < 0. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1745889DOI Listing

Association between red blood cell distribution width and long-term mortality among patients undergoing percutaneous coronary intervention with previous history of cancer.

Biomarkers 2020 May 6;25(3):260-267. Epub 2020 Mar 6.

Clinical Medical College of Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.

The number of patients suffering from coronary heart disease with cancer is rising. There is scarce evidence concerning the biomarkers related to prognosis among patients undergoing percutaneous coronary intervention (PCI) with cancer. Thus, the aim of this study was to investigate the association between red blood cell distribution width (RDW) and prognosis in this population. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1734860DOI Listing

Diagnostic utility of MR-proANP and NT-proBNP in elderly outpatients with a high risk of heart failure: the Copenhagen heart failure risk study.

Biomarkers 2020 May 4;25(3):248-259. Epub 2020 Mar 4.

Department of Cardiology, Herlev and Gentofte University Hospital, Herlev, Denmark.

Amino-terminal-pro-B-type-natriuretic-peptide (NT-proBNP) is a diagnostic biomarker for heart failure (HF), but plasma concentrations are influenced by numerous factors. Mid-regional-pro-atrial-natriuretic-peptide (MR-proANP) have comparable diagnostic value in acute HF. However, data are lacking in the non-acute setting. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1732466DOI Listing

Protective effect of rosemary () against diethylnitrosamine-induced renal injury in rats.

Biomarkers 2020 May 12;25(3):281-289. Epub 2020 Mar 12.

Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt.

The kidney plays a central role in detoxification and excretion of toxic metabolites, and therefore, is susceptible to toxicity by xenobiotics. To investigate the protective effect of (rosemary) powder and its essential (volatile) oil against diethylnitrosamine (DEN)-induced renal injury in rats. Phenolic and flavonoid components were characterised in rosemary powder using HPLC-UV instrument while rosemary essential oil (E. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1737734DOI Listing

Plasma levels of nesfatin-1 as a new biomarker in depression in Asians: evidence from meta-analysis.

Biomarkers 2020 May 11;25(3):228-234. Epub 2020 Mar 11.

Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, School of Basic Medicine, Qingdao University, Qingdao, China.

This study aims to review the alteration of plasma nesfatin-1 levels in patients with depression. Under the guidance of the latest PRISMA checklist, a systematic review and meta-analysis were conducted by searching English database (PubMed, Web of Science, EMDASE) and Chinese database for relevant studies up to August, 2019. Pooled standardised mean difference (SMD) with 95% confidence intervals (CI) was calculated with the random effects model. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1736157DOI Listing
May 2020
2.522 Impact Factor

Blood biomarkers for assessment of mild traumatic brain injury and chronic traumatic encephalopathy.

Biomarkers 2020 May 12;25(3):213-227. Epub 2020 Mar 12.

School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, Australia.

Mild traumatic brain injuries (mTBI) are prevalent and can result in significant debilitation. Current diagnostic methods have implicit limitations, with clinical assessment tools reliant on subjective self-reported symptoms or non-specific clinical observations, and commonly available imaging techniques lacking sufficient sensitivity to detect mTBI. A blood biomarker would provide a readily accessible detector of mTBI to meet the current measurement gap. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1735521DOI Listing

The prognostic impact of tumour NSD2 expression in advanced prostate cancer.

Biomarkers 2020 May 2;25(3):268-273. Epub 2020 Mar 2.

Department of Urology, Medical University of Vienna, Vienna, Austria.

To assess the prognostic significance of the nuclear receptor binding SET protein 2 (NSD2), a co-activator of the NFkB-pathway, on tumour progression in patients with advanced prostate cancer (PCa). We retrospectively assessed NSD2 expression in 53 patients with metastatic and castration-resistant PCa. Immunohistochemical staining for NSD2 was carried out on specimen obtained from palliative resection of the prostate. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1734861DOI Listing

Dynamic thiol/disulphide homeostasis as indicator of oxidative stress in automotive workers.

Biomarkers 2020 May 2;25(3):274-280. Epub 2020 Mar 2.

Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey.

To examine thiol-disulphide homeostasis auto painters. A total of 115 male workers, including 60 auto painters workers and 55 reference group, of the painting and assembly line units respectively, were included in the study. Thiol-disulphide parameters and ischaemia-modified albumin (IMA) of groups were determined. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1734862DOI Listing
May 2020
2.522 Impact Factor

High-frequency metabolite profiling and the incidence of recurrent cardiac events in patients with post-acute coronary syndrome.

Biomarkers 2020 May 27;25(3):235-240. Epub 2020 Feb 27.

Department of Cardiology, Erasmus University Medical Centre (Erasmus MC), Rotterdam, the Netherlands.

The aim of this study was to study temporal changes in metabolite profiles in patients with post-acute coronary syndrome (ACS), in particular prior to the development of recurrent ACS (reACS). BIOMArCS (BIOMarker study to identify the Acute risk of a Coronary Syndrome) is a prospective study including patients admitted for ACS, who underwent high-frequency blood sampling during 1-year follow-up. Within BIOMArCS, we performed a nested case-cohort analysis of 158 patients (28 cases of reACS). Read More

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http://dx.doi.org/10.1080/1354750X.2020.1731762DOI Listing

Prognostic value of pre-treatment red blood cell distribution width in lung cancer: a meta-analysis.

Biomarkers 2020 May 27;25(3):241-247. Epub 2020 Feb 27.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China.

In recent years, increasing studies found that pre-treatment red blood cell distribution width (RDW) could predict clinical outcomes in various cancers. However, the prognostic value of pre-treatment RDW in lung cancer was inconsistent. Therefore, we performed a meta-analysis to determine prognostic value of pre-treatment RDW in lung cancer. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1731763DOI Listing

Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure).

Biomarkers 2020 Mar 16;25(2):201-211. Epub 2020 Feb 16.

CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), INSERM U1116, Centre d'Investigation Clinique et Plurithématique 1433, INSERM, Université de Lorraine, Nancy, France.

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome for which clear evidence of effective therapies is lacking. Understanding which factors determine this heterogeneity may be helped by better phenotyping. An unsupervised statistical approach applied to a large set of biomarkers may identify distinct HFpEF phenotypes. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1727015DOI Listing

Relationship between autoantibodies to erythropoietin receptor and renal outcome in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.

Biomarkers 2020 Mar 13;25(2):194-200. Epub 2020 Feb 13.

Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

We examined the relationship between autoantibodies to erythropoietin receptor (EPOR) and renal outcome in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Sixty-three Japanese patients with AAV were enrolled and followed for a median of 31.4 months. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1727014DOI Listing

Diagnosis of acute intoxications in critically ill patients: focus on biomarkers - part 2: markers for specific intoxications.

Biomarkers 2020 Mar 10;25(2):112-125. Epub 2020 Feb 10.

Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

In medical intensive care units, acute intoxications contribute to a large proportion of all patients. Epidemiology and a basic overview on this topic were presented in part one. The purpose of this second part regarding toxicological biomarkers in the ICU setting focuses on specific poisons and toxins. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1725787DOI Listing

Elevated CEA and CA19-9 serum levels independently predict advanced pancreatic cancer at diagnosis.

Biomarkers 2020 Mar 13;25(2):186-193. Epub 2020 Feb 13.

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

It is suggested that tumour markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) could be used to predict the stage of pancreatic cancer. However, optimal cut-off values for CEA and CA19-9 are disputable. This study aimed to assess the value of CEA and CA19-9 serum levels at diagnosis of pancreatic ductal adenocarcinoma (PDAC) as predictors for the advanced stage of PDAC in patients discussed at pancreatic multidisciplinary team (MDT) meetings. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1725786DOI Listing

Occupational low-level exposure to hard metals: cobalt and tungsten biomonitoring as an effective tool to evaluate the effectiveness of industrial hygiene interventions for risk management.

Biomarkers 2020 Mar 6;25(2):179-185. Epub 2020 Feb 6.

Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Section of Public Health and Human Sciences, University of Brescia, Brescia, Italy.

The aim of the study was to assess the exposure to Cobalt (Co) and Tungsten (W) in a group of hard metal tool sharpeners through a combined approach of air and biological monitoring, and to evaluate the effectiveness of a control and improvement intervention carried out in collaboration with the medical officers of the local Health Protection Agency, by biomonitoring. We enrolled 132 workers from 17 companies of the province of Brescia, northern Italy. The study was performed in two phases: (1) an environmental and biomonitoring survey to assess the workers' exposure to Co and W at their usual working conditions; (2) a further biomonitoring survey 3 months after the enforcement of a control and improvement intervention, to assess its effectiveness. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1724195DOI Listing

Predictive value of metabolomic biomarkers for cardiovascular disease risk: a systematic review and meta-analysis.

Biomarkers 2020 Mar 29;25(2):101-111. Epub 2020 Jan 29.

Department of Internal Medicine and Cardiology, Charité - Campus Virchow-Klinikum, Berlin, Germany.

Metabolomic analysis aids in the identification of novel biomarkers by revealing the metabolic dysregulations underlying cardiovascular disease (CVD) aetiology. The aim of this study was to evaluate which metabolic biomarkers could add value for the prognosis of CVD events using meta-analysis. The PRISMA guideline was followed for the systematic review. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1716073DOI Listing

A specific autoantibody against a novel tumour-association antigen derived from human DNA-topoiomerase I is a potential biomarker for early diagnosis and favourable prognosis in patients with colorectal carcinoma.

Biomarkers 2020 Mar 27;25(2):149-156. Epub 2020 Jan 27.

Chengdu Cancer Bioengineering Research Institute, Chengdu, PR China.

We previously reported a novel tumour associated antigen (TTA) with molecular weight around 48 kDa and identified the novel TTA as a fragment derived from human DNA-topoiomerase I (TOP1). We termed the novel TAA as TOPO48 and termed autoantibody against the TAA as anti-TOPO48 autoantibody. To explore the clinical significance of anti-TOPO48 autoantibody in patients with colorectal carcinoma (CRC). Read More

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http://dx.doi.org/10.1080/1354750X.2020.1714734DOI Listing

Pre-procedural elevated cardiac troponin predict risk of long-term all-cause mortality after transcatheter aortic valve replacement: a meta-analysis of prospective studies.

Biomarkers 2020 Mar 24;25(2):164-170. Epub 2020 Jan 24.

Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The purpose of this meta-analysis was to evaluate the relationship between elevated cardiac troponin pre-transcatheter aortic valve replacement (TAVR) and long-term all-cause mortality. Prospective studies with the endpoint of all-cause mortality were included. We primarily used the fixed-effect model weighted by inverse variance. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1714736DOI Listing

Investigating the role of T helper related cytokines in cerebrospinal fluid for the differential diagnosis of bacterial meningitis in pre-treated paediatric patients.

Biomarkers 2020 Mar 24;25(2):171-178. Epub 2020 Jan 24.

Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Given the challenge in the diagnosis of bacterial meningitis (BM), we assessed different cytokines in the cerebrospinal fluid (CSF) of antibiotics pre-treated patients. Laboratory tests and polymerase chain reaction (PCR) were performed for 480 CSF samples from children (2 m to 14 y), suspicious to meningitis and pre-treated with antibiotics, to detect bacterial and viral aetiologies. Sixty-one CSF were included and the levels of 13 cytokines such as IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17A, IL-17F, IL-21, IL-22, IFN-γ and TNF-α were measured using flow-cytometry. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1714737DOI Listing
March 2020
2.522 Impact Factor

Subjects with microvascular angina have longer GT repeats polymorphism in the haem oxygenase-1 gene promoter.

Biomarkers 2020 Mar 20;25(2):144-148. Epub 2020 Jan 20.

Department of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan.

Few studies have investigated haem oxygenase-1 gene (HMOX1) promoter polymorphism in microvascular angina (MVA). HMOX1 promoter (GT) repeats were examined in healthy controls ( = 220) and MVA subjects ( = 181). The distribution of genotype of SS, SL and LL were significantly different in MVA (17%, 51%, 33%) vs. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1713214DOI Listing

Diagnostic value of GLUT-1 in distinguishing malignant mesothelioma from reactive mesothelial cells: a meta-analysis.

Biomarkers 2020 Mar 21;25(2):157-163. Epub 2020 Jan 21.

Department of Pathology and Clinical Laboratory, 96601 Army Hospital of People's Liberation Army, Huangshan, China.

Previous studies have demonstrated the diagnostic value of glucose transporter 1 (GLUT-1) to distinguish malignant mesothelioma (MM) from reactive mesothelial cells (RMC), but the results are inconsistent. The purpose of this meta-analysis is to investigate the diagnostic accuracy of GLUT-1 in distinguishing MM from RMC. A systematical search was conducted until May 2019 in PubMed, Medline, Embase and the Cochrane Library. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1714735DOI Listing

Biomarker-specific differences between transpulmonary and peripheral arterial-venous blood sampling in patients with pulmonary hypertension.

Biomarkers 2020 Mar 9;25(2):131-136. Epub 2020 Jan 9.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

: Transpulmonary biomarkers may provide insight into pulmonary hypertension (PH) pathophysiology, but require cardiac catheterization. We investigated whether the peripheral arterial-venous ratio (PR) could substitute for the transpulmonary ratio (TPR). Blood from the pulmonary artery (PA), pulmonary arterial wedge (PAW), peripheral venous, and peripheral arterial positions was analysed for ET-1, NT-pro-BNP and cAMP levels in subjects with no PH ( = 18) and PH due to left heart disease (PH-LHD), which included combined pre- and post-capillary PH (Cpc-PH;  = 7) and isolated post-capillary PH (Ipc-PH;  = 9). Read More

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http://dx.doi.org/10.1080/1354750X.2019.1710256DOI Listing

Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction.

Biomarkers 2020 Mar 8;25(2):137-143. Epub 2020 Jan 8.

The Heart Centre, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of biomarkers reflecting neuroendocrine response (copeptin, mid-regional-pro-adrenomedullin, pro-atrial-natriuretic-peptide, soluble thrombomodulin (sTM), syndecan-1) and inflammation (suppression-of-tumorigenicity 2 (ST2), high-sensitive C-reactive-protein) in TTC patients and compared to patients with acute anterior STEMI. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1710767DOI Listing

Association between smoking status and homocysteine levels and possible effect modification by cholesterol and oestradiol.

Biomarkers 2020 Mar 26;25(2):126-130. Epub 2019 Dec 26.

Department of Health Services Management and Policy, College of Public Health, East Tennessee State University, Johnson City, TN, USA.

This study aimed to examine the association of smoking status with homocysteine levels and to determine whether the association is modified by oestradiol or cholesterol. Data ( = 4580) were obtained from National Health and Nutrition Examination Survey 2003-2004 with analysis done in 2018 on adults aged ≥20 years. The outcome was homocysteine; smoking status was the exposure variable and categorized as current, former or never smoker. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1705395DOI Listing
March 2020
2.522 Impact Factor

Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats.

Biomarkers 2020 Feb 6;25(1):86-93. Epub 2019 Dec 6.

Department of Therapeutic Chemistry, National Research Center, Giza, 12622, Egypt.

Paracetamol (PAR) and diclofenac (DF) are the most popular consumed analgesics and anti-inflammatory medications. This study aimed to explore the protective effect of betanin (Bet) against PAR or DF induced hepato-renal damage in rats. Rats were randomly divided into five groups: Normal control (NC) group rats were given saline only. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1697365DOI Listing
February 2020

The progressive alteration of urine metabolomic profiles of rats following long-term and low-dose exposure to permethrin.

Biomarkers 2020 Feb 1;25(1):94-99. Epub 2019 Dec 1.

Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.

Permethrin is a type of widely used pyrethroid pesticide. Although acute toxicity of permethrin has been well-characterised, the non-acute toxicity of permethrin upon long-term exposure at low dose has been seldom studied yet. The current study investigates the time-course change of the metabolomic profiles of urine following the low level long-term exposure of permethrin and identified biomarkers of the chronic toxicity of permethrin. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1697755DOI Listing
February 2020

Clinicopathologic features and prognostic significance of CD30 expression in diffuse large B-cell lymphoma (DLBCL): results in a homogeneous series from a single institution.

Biomarkers 2020 Feb 21;25(1):69-75. Epub 2019 Nov 21.

Department of Clinical Haematology, Institut Català Oncologia (ICO)-Hospitalet, IDIBELL, Barcelona, Spain.

The present study evaluates CD30 expression by immunohistochemistry (IHQ) in 216 patients with DLBCL. CD30 expression was assessed retrospectively in all cases by IHQ. More than >0% and >20% of CD30 expression in the malignant cells were used as a cut-off for positivity. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1691656DOI Listing
February 2020

Diagnosis of acute intoxications in critically ill patients: focus on biomarkers - part 1: epidemiology, methodology and general overview.

Biomarkers 2020 Feb 26;25(1):9-19. Epub 2019 Nov 26.

Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Acute intoxications account for a significant proportion of the patient population in intensive care units and sedative medications, ethanol, illicit drugs, inhalable poisons and mixed intoxications are the most common causes. The aim of this article is to describe biomarkers for screening and diagnosis of acute intoxications in critically ill patients. For this purpose, a survey of the relevant literature was conducted, and guidelines, case reports, expert assessments, and scientific publications were reviewed. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1694994DOI Listing
February 2020

Circulating microRNA as biomarkers of clozapine-induced cardiotoxicity.

Biomarkers 2020 Feb 21;25(1):76-85. Epub 2019 Nov 21.

Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

This work investigated the utility of circulating microRNA (miRNA) as biomarkers of clozapine (CLZ)-induced cardiotoxicities: serious adverse events with an unusually high incidence in Australia and New Zealand. Global plasma miRNA expression was analysed by microarray in patients taking CLZ, to investigate differential expression between CLZ-induced cardiotoxicity cases ( = 6) and matched control patients ( = 12). The results were validated by RT-qPCR using a panel of 17 miRNA, and their expression was examined in both CLZ-naïve healthy volunteers ( = 12) and an expanded cohort of CLZ-taking patients ( = 21). Read More

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http://dx.doi.org/10.1080/1354750X.2019.1693631DOI Listing
February 2020

Gastroprotective effect of leaf extract of two varieties grapevine ( L.) native wild and cultivar grown in North of Tunisia against the oxidative stress induced by ethanol in rats.

Biomarkers 2020 Feb 19;25(1):48-61. Epub 2019 Nov 19.

Environment Biomonitoring Laboratory (LR01/ES14), Department of Life Sciences, Bizerta Faculty of Sciences, University of Carthage, Zarzouna, Tunisia.

leaves are traditionally used in Tunisian folk medicine to treat digestive pathologies. We aimed to compare the gastroprotective effects of hydromethanolic leaves extracts of wild and cultivated grapes accessions native of Tunisia. The phytochemical analysis of grapevine leaves extracts was performed. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1691266DOI Listing
February 2020

Role of glial fibrillary acidic protein as a biomarker in differentiating intracerebral haemorrhage from ischaemic stroke and stroke mimics: a meta-analysis.

Biomarkers 2020 Feb 28;25(1):1-8. Epub 2019 Nov 28.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Studies have suggested promising evidence that glial fibrillary acidic protein (GFAP) could be used as a blood biomarker to distinguish between ischaemic stroke (IS) and intracerebral haemorrhage (ICH) in acute stage. To determine the available evidence for GFAP as a blood biomarker for differentiating ICH from IS and stroke mimics using a meta-analysis approach. Search terms were used for literature search: ("STROKE" [Mesh] OR "BIOMARKER" [Title/Abstract] OR "GFAP" [Title/Abstract])] OR "SPECIFICITY" OR "SENSTIVITY" at various search engines like PubMed, Google scholar, Trip database, clinicaltrial. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1691657DOI Listing
February 2020
2.522 Impact Factor

Tissue-based miRNA mapping in alcoholic liver cirrhosis: different profiles in cirrhosis with or without hepatocellular carcinoma.

Biomarkers 2020 Feb 14;25(1):62-68. Epub 2019 Nov 14.

Department of Thoracic and Vascular Surgery, University of Leipzig, Leipzig, Germany.

Alcoholic liver cirrhosis is a significant risk factor for the development of hepatocellular carcinoma (HCC). The importance of tumour-associated cirrhosis in the development or progression of HCC is not understood. MiRNAs are important regulators for HCC development, but their role in HCC due to alcoholic liver cirrhosis is unclear. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1691267DOI Listing
February 2020

New potential modulators of CYP4F2 enzyme activity in angina pectoris: hsa-miR-24-3p and hsa-miR-34a-5p.

Biomarkers 2020 Feb 14;25(1):40-47. Epub 2019 Nov 14.

Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

To find an association of relative expression of hsa-miR-24-3p and hsa-miR-34a-5p molecules and CYP4F2 enzyme activity in blood plasma of stable angina pectoris (AP) patients'. MiRNA gene expression analysis was performed on total RNA extracted from blood plasma, using quantitative real-time polymerase chain reaction. CYP4F2 enzyme levels were determined using commercial ELISA kit. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1690580DOI Listing
February 2020

Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?

Biomarkers 2020 Feb 14;25(1):34-39. Epub 2019 Nov 14.

Department of Urology, Second Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czech Republic.

Prostate-specific antigen (PSA) is a sensitive but unspecific marker for prostate cancer (PC) detection, which may result in harms including overdiagnosis and overtreatment. Therefore, the development of new markers is of absolute value. The urinary level of engrailed-2 (EN2) protein has been recently suggested as a promising PC biomarker, correlating with tumour volume and stage. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1690047DOI Listing
February 2020

Nicotine metabolite ratios in serum and urine among US adults: variations across smoking status, gender and race/ethnicity.

Authors:
Ram B Jain

Biomarkers 2020 Feb 14;25(1):27-33. Epub 2019 Nov 14.

Independent Researcher, Dacula, GA, USA.

The objective of this study was to evaluate factors affecting variabilities in the observed levels of nicotine metabolite ratios in serum (NMR,  = 10,234) and urine (NMR,  = 2286) for US adults aged ≥20 years. Data from NHANES were used to fit regression models for log10 transformed values of NMR and NMR stratified by gender and smoking status. Females had higher NMR than males among both smokers and non-smokers. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1688866DOI Listing
February 2020
2.522 Impact Factor

Early serum cystatin C-enhanced risk prediction for acute kidney injury post cardiac surgery: a prospective, observational, cohort study.

Biomarkers 2020 Feb 14;25(1):20-26. Epub 2019 Nov 14.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Acute kidney injury (AKI) is a common post-cardiac surgery complication. It leads to increased morbidity and mortality. The aim of our study is to identify the prevalence and risk factors of AKI and to demonstrate if early postoperative serum cystatin C (sCyC) could accurately predict the development of AKI. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1688865DOI Listing
February 2020

Tumour necrosis factor like cytokine 1A levels and lesion complexity in non-smoking patients with coronary artery disease.

Biomarkers 2019 Dec 5;24(8):764-770. Epub 2019 Nov 5.

Department of Biochemistry, Namık Kemal University Medicine School, Tekirdağ, Turkey.

Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-α), is a novel indicator of atherosclerosis. Smoking is an established stimulant of TNF-α. We aimed to investigate whether TLA1 plays a role in the presence and complexity of coronary artery atherosclerosis, exclusively in non-smoking patients with CAD. Read More

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http://dx.doi.org/10.1080/1354750X.2019.1685004DOI Listing
December 2019
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