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Biomarkers 2019 Apr 19:1-30. Epub 2019 Apr 19.

a Developmental Toxicology Laboratory, System Toxicology & Health Risk Assessment Group , CSIR-Indian Institute of Toxicology Research (CSIR-IITR) , Vishvigyan Bhawan, 31, Mahatma Gandhi Marg , Lucknow - 226001 , U.P , India.

Purpose: To develop peripheral blood mRNA expression profiles of drug metabolizing enzymes (DMEs) as a surrogate to monitor tobacco induced head & neck squamous cell carcinoma (HNSCC), attempts were made to investigate i) similarities in alterations with the cancer marker genes in biopsy samples, and ii) if alterations similar to that seen in biopsy samples are reflected in peripheral blood.

Methods: Total RNA from eight soft gingival tissues and eight biopsy samples of HNSCC patients and total DNA and RNA from blood of healthy controls (n = 150) and HNSCC patients (n = 150) was processed for expression and genotyping studies. Blood from patients receiving chemo-radiotherapy was processed for follow-up study Results: qRT-PCR revealed significant increase in mRNA expression of DMEs in biopsy and blood samples of HNSCC patients when compared to controls. Read More

Biomarkers 2019 Apr 17:1-31. Epub 2019 Apr 17.

a Department of Paediatrics, Haematology and Oncology , Medical University of Gdansk , Poland.

Objective The study was to assess whether tumour expressions of hypoxia-inducible factor (HIF)-1α, glucose transporter (GLUT)-1, carbonic anhydrase (CA)IX and vascular endothelial growth factor (VEGF) predict response to neo-adjuvant chemotherapy (naCHT) in children with inoperable rhabdomyosarcoma (RMS). Methods Immunohistochemical expressions of hypoxia markers were determined semi-quantitatively in tumour tissue microarray of 46 patients with embryonal RMS (RME) and 20 with alveolar (RMA), treated with CWS protocols (1992-2013). Results In paediatric RME, response to naCHT was influenced significantly by tumour expression of CA IX and GLUT-1. Read More

Biomarkers 2019 Apr 16:1-41. Epub 2019 Apr 16.

a Division of Molecular Biology , Instituto Potosino de Investigación Científica y Tecnológica , San Luis Potosí , SLP , México.

Context: Differential expression profiles of microRNAs have been reported in human obesity suggesting a miRNAs role in the development of obesity and associated disorders.

Objective: To review circulating microRNAs (c-miRNAs) dysregulated in human obesity and to predict their possible target genes.

Methods: We performed a systematic review on PubMed database (PROSPERO, CRD42017077742) for original works on c-miRNAs and human obesity and recorded c-miRNAs with differential expression profiles. Read More

Biomarkers 2019 Apr 12:1-34. Epub 2019 Apr 12.

b Special Food and Nutrition Department , Food Technology Research Institute, Agriculture Research Center , Giza , Egypt.

Context: Chronic liver damage has serious medical consequences.

Objective: To investigate the hepatoprotective effect of dry Zingiber officinale (ginger) and its essential (volatile) oil against diethylnitrosamine (DEN) toxicity in rats.

Materials And Methods: Phenols and flavonoids components were characterized in dry ginger using HPLC-UV instrument while ginger essential oil (E. Read More

Biomarkers 2019 Apr 12:1-26. Epub 2019 Apr 12.

b Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University , Shiwa-gun , Iwate , Japan.

Purpose: Elevation of high-sensitivity cardiac troponin T (hs-cTnT) is associated with an increased risk of cardiovascular disease (CVD). This study determined whether hs-cTnT was detectable with N-terminal pro-b-type natriuretic peptide (NT-proBNP) and related to CV risk factors in a general Japanese population.

Materials And Methods: The Tohoku Medical Megabank Organization pooled individual participant data for a population-based cohort study in the Iwate prefecture (n = 30,193, age =60. Read More

Biomarkers 2019 Apr 11:1-30. Epub 2019 Apr 11.

c Department of Anesthesiology, State Key Laboratory of Cardiovascular Disease , Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100037 , China.

Background: Predictive value of cardiac tropnins (cTns) in stable coronary artery disease (SCAD) has not been fully investigated.

Methods: We performed a meta-analysis to evaluate the dose-response relationship between serum detectable/rising cTns and adverse clinical outcomes, including all-cause mortality, cardiovascular (CV) mortality, myocardial infarction (MI), heart failure (HF) or major adverse cardiovascular events (MACEs) in SCAD.

Results: 16 studies involved 34 854 subjects were included. Read More

Biomarkers 2019 Mar 29:1-25. Epub 2019 Mar 29.

a University of Tunis El Manar, Rabta Hospital, Laboratory of Biochemistry, Faculty of Medicine of Tunis , Tunis , Tunisia.

Context: Cluster of differentiation 40 (CD40), and its ligand CD40L, are major co-stimulatory molecules whose interactions are important in both cellular and humoral immunity, and has been suggested to play a role in the pathogenesis of acute coronary syndrome.

Objective: The aim of this study was to examine the association of CD40 polymorphisms (-1 C > T (rs1883832) and 945G > T (rs4810485)) and myocardial infarction (MI), and to test the association of CD40 gene haplotypes with MI in Tunisians.

Materials And Methods: Three hundred and fifty MI patients and 301 apparently healthy controls were included in the study. Read More

Biomarkers 2019 Mar 25:1-7. Epub 2019 Mar 25.

d Department of Biology, Faculty of Nature and Life and Earth Sciences and the Universes, University of Guelma , Guelma , Algeria.

Objective: This work aimed to study the effect of temperature in variation of fatty acid profiles of virgin olive oil (VOO) and to evaluate the impact of the consumption of this thermo oxidized VOO on metabolic oxidative stress.

Materials And Methods: Effect of consumption of fresh or thermo-oxidized VOO on rabbits was studied. The animals were distributed in groups of six rabbits each and were fed for four weeks with the incorporation of 15% VOO either fresh or heated during one, two, three or four hours. Read More

Biomarkers 2019 Mar 25:1-7. Epub 2019 Mar 25.

a School of Science and Technology , University of New England , Armidale , Australia.

Purpose: This study examined whether circulating C-reactive protein (CRP) is elevated in obstructive sleep apnoea (OSA) independent of the confounding effects of comorbidities, smoking, body mass index (BMI), age and gender.

Methods: A systematic review of the literature was performed using PubMed, Embase and Cochrane databases from 1 January 1997 to 1 November 2017 using the key words obstructive sleep apnoea and C-Reactive protein to identify full text English language studies that compared CRP in adult non-smoking OSA participants without comorbidities and adult healthy non-smoking control participants matched for BMI, age and gender. Data from eligible studies were subjected to meta-analysis using RevMan version 5. Read More

Biomarkers 2019 Mar 25:1-7. Epub 2019 Mar 25.

a School of Human Movement Studies , Centre for Research on Exercise, Physical Activity and Health, The University of Queensland , Brisbane , Australia.

Purpose: Oxidative stress (OS) has been implicated in the pathogenesis of metabolic syndrome (MetS). The acute change in OS biomarkers due to exercise, known as exercise-induced OS (EIOS), is postulated to be a more appropriate marker of OS compared to spot OS measures. These studies objectives were to investigate EIOS in participants with MetS and compare the associations between EIOS, spot OS measures and MetS severity. Read More

Biomarkers 2019 Mar 25:1-6. Epub 2019 Mar 25.

b Minsk Scientific Practical Center of Surgery, Transplantation and Hematology , Minsk , Belarus.

Background: Invasive fungal infections are a major threat to a large cohort of immunocompromised patients, including patients with chemotherapy-associated neutropenia. Early differential diagnosis with bacterial infections is often complicated, which leads to a delay in empirical antifungal therapy and increases risk for adverse outcome. Accessibility and performance of specific fungal antigen and PCR-tests are still limited, while sepsis biomarkers are more broadly used in most settings currently. Read More

Biomarkers 2019 Mar 25:1-5. Epub 2019 Mar 25.

f Faculty of Medicine , University of Medicine and Pharmacy Cluj-Napoca , Sibiu , Romania.

Background: There are only limited data in the literature on the thrombotic risk of patients with Clostridium difficile (CD) colitis, although this disease is widespread throughout the world.

Objective: The aim of this study was to explore thrombin generation in these patients - the best way to evaluate their coagulation.

Methods: A prospective observational study was conducted during 15 months on hospitalized patients with CD colitis. Read More

Biomarkers 2019 Mar 1:1-14. Epub 2019 Mar 1.

c Department of Cardiovascular Medicine , Beijing University of Traditional Chinese Medicine Third Affiliated Hospital , Beijing , China , 100029.

Objective: Controversial results exist with respect to the association between elevated homocysteine level and adverse prognosis in acute coronary syndrome (ACS) patients. We performed a meta-analysis to evaluate the prognostic value of homocysteine level on ACS patients.

Materials And Methods: A comprehensive literature search of PubMed and Embase databases was conducted prior to August 2018. Read More

Biomarkers 2019 Mar 1:1-6. Epub 2019 Mar 1.

a Nordic Bioscience , Biomarker and Research , Herlev , Denmark.

Objective: The objective was to investigate blood-based biomarkers of type I (PRO-C1), III (PRO-C3) and VI (PRO-C6) collagen formation in systemic sclerosis (SSc) patients and examine their correlation to modified Rodnan skin score (mRSS).

Methods: Limited (lSSc, n = 76) and diffuse SSc (dSSc, n = 41) fulfilling the ACR/EULAR 1980 and 2013 classification criteria for SSc and asymptomatic controls (n = 9) were included. PRO-C1, PRO-C3 and PRO-C6 were measured in serum. Read More

Biomarkers 2019 Mar 1:1-10. Epub 2019 Mar 1.

a Department of Environmental Health Science , College of Public Health, University of Georgia , Athens , GA , USA.

Context: Fumonisins (FNs), a group of mycotoxins produced mainly by Fusarium species, are ubiquitous food contaminants, especially for maize. Fumonisin B (FB) caused severe toxicities in farm animals, induced kidney and liver tumours in rodents and is associated with many human adverse health effects, including oesophageal cancer. International Agency for Research on Cancer (IARC) categorizes FB as a possible human carcinogen (Group 2B). Read More

Biomarkers 2019 Mar 14:1-13. Epub 2019 Mar 14.

a Department of Internal Medicine , University Medical Center Groningen and University of Groningen , Groningen , The Netherlands.

Background: C14:0, C15:0, C17:0 and trans-C16:1(n-7) are often used as biomarkers for dairy fat intake. Trans-C18:1(n-7) and CLA, two fatty acids which are also present in dairy, have hardly been explored. We investigated whether trans-C18:1(n-7) and CLA can enrich the existing biomarker portfolio. Read More

Biomarkers 2019 Feb 15:1-10. Epub 2019 Feb 15.

b School of Public Health , Anhui Medical University , Hefei , Anhui , China.

Objective: Ras association domain family 1 A (RASSF1A) has been regarded as a biomarker predicting the prognosis of non-small cell lung cancer (NSCLC), but previous findings are inconsistent. This meta-analysis of prospective studies aimed to assess the value of RASSF1A methylation in predicting the prognosis of NSCLC patients.

Methods: Studies were searched in PubMed and Web of Science. Read More

Biomarkers 2019 Feb 12:1-8. Epub 2019 Feb 12.

a Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Vermont College of Medicine , Burlington , VT , USA.

Purpose: Bronchoalveolar fluid (BALF) and plasma biomarkers are often endpoints in early phase randomized trials (RCTs) in acute respiratory distress syndrome (ARDS). With ARDS mortality decreasing, we analyzed baseline biomarkers in samples from contemporary ARDS patients participating in a prior RCT and compared these to historical controls.

Materials And Methods: Ninety ARDS adult patients enrolled in the parent trial. Read More

Biomarkers 2019 Feb 8:1-11. Epub 2019 Feb 8.

b Vibrant Sciences LLC. , San Carlos , CA , USA.

Objective: Wheat-related disorders are a spectrum of disorders associated with different autoimmune and non-autoimmune diseases. However, it is unclear whether these wheat-related disorders lead to adverse health effects such as cardiovascular risk, nutritional deficiencies etc. The objective of the study was to explore the lipid profiles and the nutritional status of subjects with wheat-related disorders to understand the potential threat by wheat on cardiovascular risk and nutritional deficiency. Read More

Biomarkers 2019 Jan 21:1-11. Epub 2019 Jan 21.

a College of Life Science, Institute of Health & Population Northwest University , Xi'an , China.

Background: The serum lipid profile has become a routine clinical test and used as an important predictor for Alzheimer's disease (AD), although its predictive value remains undetermined.

Objective: To evaluate the role of serum lipid levels in predicting the risk of AD.

Methods: Meta-analyses were conducted using Comprehensive Meta-analyses (CMA) software to investigate the association between four conventional serum lipid profile parameters and the risk of AD, focused on samples from Asian. Read More

Biomarkers 2019 Jan 11:1-7. Epub 2019 Jan 11.

a Heart Institute, Hospital Universitari Germans Trias i Pujol , Badalona , Spain.

Background: In asymptomatic severe aortic stenosis (ASAS), treatment decisions are made on an individual basis, and case management presents a clinical conundrum.

Methods: We prospectively phenotyped consecutive patients with ASAS using echocardiography, exercise echocardiography, cardiac MRI and biomarkers (NT-proBNP, high-sensitivity troponin T (hs-TnT) and ST2) (n = 58). The primary endpoint was a composite of cardiovascular death, new-onset symptoms, cardiac hospitalization, guideline-driven indication for valve replacement and cardiovascular death at 12 months. Read More

Biomarkers 2019 Jan 9:1-9. Epub 2019 Jan 9.

c Endocrine Physiology Research Center , Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Aim: This study was conducted to investigate whether serum NO metabolites (NOx) could predict the occurrence of type 2 diabetes (T2DM), hypertension (HTN) and metabolic syndrome (MetS).

Methods: We measured serum NOx concentrations in the Tehran Lipid and Glucose Study participants (aged ≥19 years) and followed them for a median of 7.7 years for the incidence of outcomes. Read More

Biomarkers 2018 Dec 11:1-21. Epub 2018 Dec 11.

a Departamento de Medicina Legal , Etica Medica, Medicina Social e do Trabalho, Instituto Oscar Freire, LIM-40, Faculdade de Medicina FMUSP, Universidade de Sao Paulo , SP , BR.

Purpose: GSTM1 and GSTT1 present a polymorphism that can drive complete gene deletions. The current methodology can powerfully determine GSTM1 and GSTT1 copy number variations (CNVs), which may clarify the real contribution of each gene copies to the cellular detoxification process and tumour risk. However, only analysing the presence/absence of these genes yielded controversial results for several disorders, including cancer. Read More

Biomarkers 2018 Dec 6:1-15. Epub 2018 Dec 6.

a Children's Medical Center , Taichung Veterans General Hospital , Taichung , Taiwan.

Purpose: Hypercatecholaminemia-related heart failure has been proposed as the main cause of enterovirus A71-related (EV-A71) early mortality. The purpose of this study was to measure urine catecholamine concentrations in severe EV-A71-infected children.

Methods: A total of 35 children, aged 2. Read More

Biomarkers 2018 Dec 5:1-23. Epub 2018 Dec 5.

a Department of Pediatric Nephrology , Wrocław Medical University , Poland.

Context: Chronic kidney disease (CKD) is characterized by immunocompetent cell migration and inflammation. Monocyte chemoattractant protein (MCP)-1 and macrophage colony-stimulating factor (MCSF) stimulate monocyte migration and transition into macrophages, with subsequent release of neopterin.

Objective: The aim of the study was to analyze these parameters in children with various stages of CKD. Read More

Biomarkers 2018 Dec 4:1-7. Epub 2018 Dec 4.

a Department of Cardiology , Erasmus University Medical Centre , Rotterdam , The Netherlands.

Purpose: We assessed the temporal pattern of 29 immune and inflammatory proteins in post-acute coronary syndrome (ACS) patients, prior to the development of recurrent ACS.

Methods: High-frequency blood sampling was performed in 844 patients admitted for ACS during one-year follow-up. We conducted a case-control study on the 45 patients who experienced reACS (cases) and two matched event-free patients (controls) per case. Read More

Biomarkers 2018 Nov 16:1-13. Epub 2018 Nov 16.

a Interdisciplinary Department of Medicine (DIM) , Section "B. Ramazzini", University Hospital "Policlinico", Unit of Occupational Medicine, School of Medicine, University of Bari , Bari , Italy.

Purpose: The evaluation of the association between different exposure to pesticides and different types of comet images among a group of 26 recruited subject.

Material And Methods: We have recruited 26 subjects (farmers and not farmers). They were submitted to a blood drawing of 10 mL and a questionnaire was administered to investigate personal habits and work history. Read More

Biomarkers 2018 Dec 4:1-16. Epub 2018 Dec 4.

a Genetics and Molecular Biology Laboratory, Department of Zoology , University of North Bengal , P.O. NBU , Dist. Darjeeling, 734013 , West Bengal , India.

Context: Pesticide poisoning and related deaths is a global concern, but there is little information about its effect on the occupationally exposed tea garden workers of North Bengal.

Objective: This study investigates the level of AChE and BuChE in the blood of the tea garden workers, at risk of exposure to a mixture of pesticides.

Materials And Methods: The study sample consisted of pesticide exposed workers, non exposed (control), smokers and alcoholics. Read More

Biomarkers 2018 Dec 4:1-27. Epub 2018 Dec 4.

a The Dartmouth Institute for Health Policy & Clinical Practice , Dartmouth Geisel School of Medicine , Lebanon , NH , USA ;

Objectives: Soluble suppression of tumorgenicity 2 (sST2) biomarker is an emerging predictor of adverse clinical outcomes, but its prognostic value for in-hospital mortality after coronary artery bypass grafting (CABG) is not well understood. This study measured the association between operative sST2 levels and in-hospital mortality after CABG.

Methods: A prospective cohort of 1,560 CABG patients were analysed from the Northern New England Cardiovascular Disease Study Group Biomarker Study. Read More

Biomarkers 2019 Jan 14:1-9. Epub 2019 Jan 14.

d Clinical Pathology Laboratory , Cairo Specialized Hospital , Cairo , Egypt.

Context: Stomach ulcers are the common gastrointestinal disorders worldwide.

Objective: This study aimed to investigate the therapeutic impact of Pulicaria crispa aerial parts ethanol extract against gastric ulcer in rats.

Materials And Methods: Ulcer was induced by one oral dose of ethanol (0. Read More

Biomarkers 2018 Nov 26:1-17. Epub 2018 Nov 26.

b U.S. Environmental Protection Agency , Exposure Methods and Measurements Division, NERL/ORD , Research Triangle Park , NC , USA.

Background: The human exposome, defined as "…everything that is not the genome", comprises all chemicals in the body interacting with life processes. The exposome drives genes x environment (GxE) interactions that can cause long-term latency and chronic diseases. The exposome constantly changes in response to external exposures and internal metabolism. Read More

Biomarkers 2018 Nov 20:1-28. Epub 2018 Nov 20.

b Clinical Development , Biogen , Cambridge , MA.

Purpose: Extracellular matrix (ECM) deposition and remodelling in skin and lungs of systemic sclerosis (SSc) subjects lead to release of metabolites/biomarkers into circulation. We investigated if biomarkers of ECM degradation (biglycan and elastin) and macrophage activation (citrullinated vimentin) could identify diffuse SSc (dSSc) subjects from controls and the biomarkers discriminative power.

Methods: DSSc subjects (n = 40) fulfilling the 2013 EULAR/ACR classification criteria were divided in early (<2years of symptoms) and late (≥10years of symptoms). Read More

Biomarkers 2018 Nov 16:1-7. Epub 2018 Nov 16.

a Department of Nephrology, Rheumatology, Endocrinology and Metabolism , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.

Purpose: The purpose of present study was to evaluate the clinical efficacy of irbesartan on the anti-inflammatory and anti-oxidative stress effect in patients with hypertension compared to other ARBs. Further, we assessed the effect of the ARBs on kidney function and urinary albumin excretion.

Methods: Eighty-five outpatients with hypertension who took an ARB except irbesartan more than 3 months were assigned into two groups, one continued the same ARB and the other switched the ARB to irbesartan for 6 months. Read More

Biomarkers 2018 Nov 15:1-7. Epub 2018 Nov 15.

e School of Medicine & Forensics, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University , Xi'an , China.

Context: Osteoporosis (OP) is a progressive systemic bone disease. Dual-energy X-ray absorptiometry (DXA) is routinely employed and is considered the gold standard method for the diagnosis of OP.

Objective: We aimed to investigate the potential use of combined information from multiple bone turnover markers (BTMs) as a clinical diagnostic tool for OP. Read More

Biomarkers 2018 Nov 9:1-8. Epub 2018 Nov 9.

a Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine , Temple University , Philadelphia , PA , USA.

Background: The aetiology and inflammatory profile of combined pulmonary fibrosis and emphysema (CPFE) remain uncertain currently.

Objective: We aimed to examine the levels of inflammatory proteins in lung tissue in a cohort of patients with emphysema, interstitial pulmonary fibrosis (IPF), and CPFE.

Materials And Methods: Explanted lungs were obtained from subjects with emphysema, IPF, CPFE, (or normal subjects), and tissue extracts were prepared. Read More

Biomarkers 2018 Nov 2:1-8. Epub 2018 Nov 2.

a Department of Environmental Immunology , Helmholtz Centre for Environmental Research GmbH - UFZ , Leipzig , Germany.

Purpose: In the peripheral blood, it has been shown that smoking is, to date, the only specific condition leading to an increase in GPR15+ T cells. We, therefore, aimed to characterize GPR15-expressing blood T cells in more detail.

Materials And Methods: The whole transcriptome by RNAseq as a proxy for protein expression was analyzed in GPR15+ and GPR15- T cells. Read More

Biomarkers 2018 Nov 2:1-10. Epub 2018 Nov 2.

a Sezione di Igiene, Istituto di Sanità Pubblica , Università Cattolica del Sacro Cuore , Roma , Italia.

Objective: The early identification of gastric cancer (GC) represents a major clinical challenge. We conducted a systematic review of studies evaluating the miRNA expression profiling as a diagnostic tool in GC.

Methods: We performed a search of PubMed, ISI Web of Science and SCOPUS databases for studies on diagnostic miRNAs and GC, published in English up to October 2017. Read More

Biomarkers 2018 Oct 30:1-6. Epub 2018 Oct 30.

a Department of Laboratory Medicine , Ryhov County Hospital , Jönköping , Sweden.

Background: Cigarette smoke induces inflammation and remodels immune response. Genetic and epigenetic alterations might be involved in the pathogenesis of smoking related diseases. In this study, we investigated the effect of smoking on systemic inflammation biomarkers and epigenetic changes at microRNA (miRNA) expression level. Read More

Biomarkers 2018 Oct 27:1-7. Epub 2018 Oct 27.

a South African Medical Research Council , Biomedical Research and Innovation Platform (BRIP) , Tygerberg , South Africa.

Background/objective: Recently, several studies have reported that DNA methylation changes in tissue are reflected in blood, sparking interest in the potential use of global DNA methylation as a biomarker for gestational diabetes mellitus (GDM). This study investigated whether global DNA methylation is associated with GDM in South African women.

Methods: Global DNA methylation was quantified in peripheral blood cells of women with (n = 63) or without (n = 138) GDM using the MDQ1 Imprint® DNA Quantification Kit. Read More

Biomarkers 2018 Nov 13:1-14. Epub 2018 Nov 13.

a Department of Chemistry and Chemical Engineering , Royal Military College of Canada , Kingston , ON , Canada.

Context: Due to the wide use of improvised explosive devices during modern warfare, primary blast-derived mild traumatic brain injury (mTBI) has become a major medical condition in the military. With minimal visually identifiable symptoms, an effective molecular biomarker system is desirable.

Objective: We assessed the potential of mammalian hair follicle miRNAs as an mTBI biomarker. Read More

Biomarkers 2018 Oct 25:1-6. Epub 2018 Oct 25.

c Sackler Faculty of Medicine, Tel Aviv Sourasky Medical Center , Department of Internal Medicine "C", "D" and "E" , Tel Aviv University , Tel Aviv , Israel.

Introduction: Metabolic syndrome (MetS) and high-sensitivity cardiac troponin T (hs-TnT) are associated with higher risk for cardiovascular diseases (CVD). Our aim was to assess the relation between hs-TnT elevation and MetS in a general population sample.

Materials And Methods: Individuals participating in an annual health survey program between 2010 and 2016 were included in the study. Read More

Biomarkers 2018 Sep 28:1-7. Epub 2018 Sep 28.

c Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen , Essen , Germany.

Purpose: Monosomy 3 (M3) in uveal melanoma (UM) obtained after enucleation is significantly associated with metastatic death. With improved biopsy techniques, samples from patients treated with eye-preserving methods have become available. As the choice of treatment depends on tumour size, patients treated with eye-preserving brachytherapy tend to have smaller tumours. Read More

Biomarkers 2018 Oct 23:1-7. Epub 2018 Oct 23.

a Department of Cardiovascular Medicine, Graduate School of Medicine , Akita University , Akita , Japan.

Background: D-serine, the enantiomer of L-serine, was identified in mammals 20 years ago. Although a close relationship between D-serine and renal dysfunction has been shown, the clinical implications of urinary D- and L-serine in humans are poorly understood. The aim of this study was to evaluate the relationship between urinary D- and L-serine with well-known renal biomarkers, and clarify the prognostic value of D- and L-serine for renal events. Read More

Biomarkers 2018 Oct 23:1-7. Epub 2018 Oct 23.

a Institute of Microbiology, University of Agriculture , Faisalabad , Pakistan.

Context: Hepatitis is an endemic disease worldwide leading to chronic and debilitating cancers. The viral agents and hepatotoxic substances lead to damage of hepatocytes and release of damage associated molecules in circulation. The lack of timely and rapid diagnosis of hepatitis results in chronic disease. Read More

Biomarkers 2018 Oct 25:1-12. Epub 2018 Oct 25.

a Centro de Investigación en Alimentación y Desarrollo, A. C. Avenida Sábalo-Cerritos s/n , Mazatlán , Mexico.

Context: Fiddler crabs are important to the ecology of estuarine systems around the world, however, few studies have incorporated them as bioindicators. Urias estuary represents one of the most urbanized lagoons in the Gulf of California region and received discharges from different sources: shrimp farm, thermoelectric plant, fish processing plants, and untreated domestic and sewage wastes.

Objective: Assess the effects on anthropogenic contamination on female fiddler crabs reproduction, survival and genetic stability. Read More

Biomarkers 2018 Oct 25:1-3. Epub 2018 Oct 25.

c Centre for Environmental Policy, Imperial College London , South Kensington, London , UK.

Context: Mupirocin (Bactroban) is widely prescribed for intra-nasal decolonisation of MRSA for in-patients awaiting surgery or self-medicated for out-patients although adherence for the latter is not monitored. Non-adherence is a widespread pharmaceutical problem but could encourage selection of antibiotic resistance. Mupirocin is only a topical antibiotic because it decomposes in stomach acidity to monic acid A, but this has not previously been exploited as a biomarker for clinical intra-nasal medication. Read More

Biomarkers 2019 Feb 28;24(1):1-16. Epub 2018 Sep 28.

a Amity Institute of Biotechnology, Amity University , Noida , India.

Context: Obstructive sleep apnoea (OSA) is a sleep respiration disorder with multiple pathophysiological risks. The study of OSA is important from a public health perspective due to increased risk of cardiovascular morbidity and metabolic disorders.

Objective: The review content contributes to amalgamate the clinico-molecular analysis of microRNAs, single-nucleotide polymorphisms (SNPs), transcriptome profiles and epigenetics in the prognosis of OSA. Read More

Biomarkers 2019 Feb 12;24(1):91-102. Epub 2018 Sep 12.

a Department of Ophthalmology, USC Keck School of Medicine , Roski Eye Institute , Los Angeles , CA , USA.

Context: Cathepsin S (CTSS) activity is elevated in Sjögren's Syndrome (SS) patient tears.

Objective: To evaluate longitudinal expression of tear and tissue CTSS activity relative to other disease indicators in Non-Obese Diabetic (NOD) mice.

Methods: CTSS activity was measured in tears and lacrimal glands (LG) from male 1-6 month (M) NOD and 1 and 6 M BALB/c mice. Read More

Biomarkers 2018 Dec 10;23(8):756-765. Epub 2018 Aug 10.

a Molecular Mechanisms of Cellular Stress and Inflammation , Intramural Research Program, National Institute on Drug Abuse , Baltimore , MD , USA.

Context: Endoplasmic reticulum (ER) calcium depletion is associated with diverse diseases, including cardiac, hepatic, and neurologic diseases.

Objective: The aim of the present study was to identify and characterize an endogenous protein that could be used to monitor ER calcium depletion comparably to a previously described exogenous reporter protein.

Materials And Methods: The use of a selective esterase-fluorescein diester pair allowed for carboxylesterase activity in extracellular fluid to be measured using a fluorescent readout. Read More

Biomarkers 2019 Feb 12;24(1):76-90. Epub 2018 Dec 12.

a Allergy and Clinical Immunology Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , 26505 , USA.

Background: Occupational exposure to the most widely used diisocyanate, 4,4'-methylene diphenyl diisocyanate (MDI), is a cause of occupational asthma (OA). Early recognition of MDI exposure and sensitization is essential for the prevention of MDI-OA.

Objective: Identify circulating microRNAs (miRs) as novel biomarkers for early detection of MDI exposure and prevention of MDI-OA. Read More