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    1438 results match your criteria Biomarkers [Journal]

    1 OF 29

    Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.
    Biomarkers 2017 Nov 16:1-9. Epub 2017 Nov 16.
    d VA Eastern Colorado Healthcare System and Division of Cardiology , University of Colorado , Denver , CO , USA.
    Aim: Novel biomarkers have been proposed for identification of patients at greater risk of future adverse events among those presenting with chest pain. In this review, we aim to elucidate the ability of pregnancy associated plasma protein-A (PAPP-A) to predict mortality and other cardiovascular events in this patient population.

    Methods: A literature search of the electronic databases Medline, Scopus, Cochrane Library and ClinicalTrials. Read More

    Alteration of salivary glycopatterns in oral lichen planus.
    Biomarkers 2017 Nov 13:1-21. Epub 2017 Nov 13.
    a Department of Immunology , the Fourth Military Medical University , Xi'an , 710032 , China.
    Background: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Read More

    Podocyturia as an Early Diagnostic Marker of Preeclampsia: A Literature Review.
    Biomarkers 2017 Nov 13:1-17. Epub 2017 Nov 13.
    b Faculty of Chemistry , University of Wroclaw , Wroclaw , Poland.
    Context: Preeclampsia (PE) is a pregnancy-related disease, and it is a leading cause of maternal and neonatal morbidity and mortality. It is characterized by the new onset of hypertension after 20 weeks of gestation together with signs of organ damage, most commonly the kidneys. The treatment of PE is symptomatic and final intervention requires delivery, regardless of the gestational age of the foetus. Read More

    Can adipokines serum levels be used as biomarkers of Hand Osteoarthritis?
    Biomarkers 2017 Nov 5:1-21. Epub 2017 Nov 5.
    c Medicine and Rheumatology Unit , Rizzoli Orthopaedic Institute , Bologna , Italy.
    Purpose: To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC).

    Methods: 94 outpatients with E HOA and NE HOA and 21 NC were enrolled. The radiological assessment of both hands was performed according to the Kellgren-Lawrence and Kallman score. Read More

    Elevated serum lactate in emergency department patients predicts hospital admission unrelated to diagnosis - but not more.
    Biomarkers 2017 Nov 20:1-9. Epub 2017 Nov 20.
    a Department of Emergency Medicine , University Hospital Jena , Jena , Germany.
    Purpose: The value of lactate as a screening biomarker in the emergency department is debated. We analysed all unselected patients in the emergency department with serum lactate measured with regard to different outcome parameters.

    Material And Methods: In a retrospective single centre study, we analysed all digitalized patient data of a two-week period of all patients ≥18 where a serum lactate was measured. Read More

    Regulation of circulating chromogranin B levels in heart failure.
    Biomarkers 2017 Nov 7:1-10. Epub 2017 Nov 7.
    a Technische Universität Dresden , Heart Center Dresden University Hospital , Dresden , Germany.
    Background: Chromogranin B (CGB) regulates B-type natriuretic peptide (BNP) production. Circulating CGB levels are elevated in heart failure (HF) animal models and HF patients, but also increase in healthy individuals in response to physical activity. Therefore, CGB seems to integrate information from myocardial stress and systemic neuro-endocrine activation. Read More

    Characterization of Organophosphate Pesticides in Urine and Home Environment Dust in an Agricultural Community.
    Biomarkers 2017 Oct 19:1-35. Epub 2017 Oct 19.
    a Institute for Risk Analysis and Risk Communication, University of Washington , Seattle , WA.
    Context: Organophosphorus insecticides (OPs) have been used to control agricultural pests found in Washington state. Farmworkers (FW) have higher exposure to OP pesticides than non-farmworkers (NFW), and FW children may in turn have higher exposure than NFW children.

    Objective: To examine the association between the concentration in house dust of five OPs used commonly in pome fruit orchards and the concentration in urine of dialkylphosphate metabolites (DAP), in a cohort of Hispanic FW and NFW and their children. Read More

    Biological monitoring of exposure to low concentrations of benzene in workers at a metallurgical coke production plant: new insights into S-phenylmercapturic acid and urinary benzene.
    Biomarkers 2017 Oct 16:1-8. Epub 2017 Oct 16.
    a Interdisciplinary Department of Medicine , Section of Occupational Medicine "E.C. Vigliani", University of Bari Aldo Moro , Bari , Italy.
    Context: Urinary S-phenylmercapturic acid (SPMA) and benzene (U-Ben) are usually measured at the end of the work shift (ES), although their kinetic of elimination is not clearly known.

    Objective: To investigate SPMA and U-Ben elimination 16 h after the ES, in 93 coke production workers exposed to low benzene concentrations.

    Materials And Methods: Airborne benzene (A-Ben) was measured by passive samplings, while SPMA, U-Ben, methyl-tert-butyl ether (U-MTBE), cotinine (U-Cot) and creatinine were determined on urine samples collected at ES and before the beginning of the next work shift (next BS). Read More

    The prognostic value of the furosemide stress test in predicting delayed graft function following deceased donor kidney transplantation.
    Biomarkers 2017 Oct 16:1-9. Epub 2017 Oct 16.
    a Division of Nephrology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
    Objectives And Methods: The Furosemide Stress Test (FST) is a novel dynamic assessment of tubular function that has been shown in preliminary studies to predict patients who will progress to advanced stage acute kidney injury, including those who receive renal replacement therapy (RRT). The aim of this study is to investigate if the urinary response to a single intraoperative dose of intravenous furosemide predicts delayed graft function (DGF) in patients undergoing deceased donor kidney transplant.

    Results: On an adjusted multiple logistic regression, a single 100 mg dose of intraoperative furosemide after the anastomosis of the renal vessels (FST) predicted the need for RRT at 2 and 6 h post kidney transplantation (KT). Read More

    Protective effect of Zizyphus lotus jujube fruits against cypermethrin-induced oxidative stress and neurotoxicity in mice.
    Biomarkers 2017 Oct 20:1-7. Epub 2017 Oct 20.
    a Faculte des Sciences de Bizerte , Universite de Carthage , Bizerte , Tunisia.
    Context: Cypermethrin (CYP) is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control. The toxicity of CYP is well studied in many organisms.

    Objective: The aim of present study was to investigate the protective effect of Zizyphus lotus (Zizyp) fruit against neurotoxicity and oxidative stress induced by CYP in mice. Read More

    Role of IL-1ra and Granzyme B as biomarkers in active Crohn's disease patients.
    Biomarkers 2017 Oct 16:1-6. Epub 2017 Oct 16.
    a Department of Medicine , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , South Korea.
    Background And Aim: Altered gene expression in intestinal mucosa is thought to contribute to inflammatory process in Crohn's disease (CD). The present study investigated changes in the expression of genes associated with gut inflammation in CD patients by RNA microarray to identify disease biomarkers.

    Methods: Microarray analysis was carried out in formalin-fixed, paraffin-embedded intestinal tissue specimens from six CD patients who underwent surgery without prior treatment and from two healthy control subjects. Read More

    Quantification of manganese and mercury in toenail in vivo using portable X-ray fluorescence (XRF).
    Biomarkers 2017 Oct 10:1-7. Epub 2017 Oct 10.
    a School of Health Sciences , Purdue University , West Lafayette , IN , USA.
    Background And Objective: Toenail is an advantageous biomarker to assess exposure to metals such as manganese and mercury. Toenail Mn and Hg are in general analyzed by chemical methods such as inductively coupled plasma mass spectrometry and atomic absorption spectrophotometry. In this project, a practical and convenient technology-portable X-ray florescence (XRF)-is studied for the noninvasive in vivo quantification of manganese and mercury in toenail. Read More

    Club cell protein (CC16) in plasma, bronchial brushes, BAL and urine following an inhaled allergen challenge in allergic asthmatics.
    Biomarkers 2017 Sep 18:1-10. Epub 2017 Sep 18.
    a Department of Clinical Sciences, Respiratory Medicine and Allergology , Lund University , Lund , Sweden.
    Background: Club cell protein (CC16) is a pneumoprotein secreted by epithelial club cells. CC16 possesses anti-inflammatory properties and is a potential biomarker for airway epithelial damage. We studied the effect of inhaled allergen on pulmonary and systemic CC16 levels. Read More

    Quantification of cotinine in dried blood spots as a biomarker of exposure to tobacco smoke.
    Biomarkers 2017 Sep 18:1-7. Epub 2017 Sep 18.
    a Department of Preventive Medicine, Feinberg School of Medicine , Northwestern University , Chicago , IL , USA.
    Objective: We present an ultra-sensitive, minimally-invasive method for quantifying cotinine in dried blood spot (DBS) samples as a biomarker of exposure to tobacco smoke that can be collected using a simple heel or finger prick to obtain blood samples.

    Methods: Cotinine levels were measured in matched plasma and reconstituted DBS samples from smokers and nonsmokers to evaluate assay parameters. In addition, we applied this new method to finger-prick DBS samples that were collected from infants, children and young adults ages 1-21 to estimate exposure to tobacco smoke. Read More

    Correlation between CAT polymorphism and susceptibility to DMAc-induced abnormal liver function: a case-control study of Chinese population.
    Biomarkers 2017 Aug 14:1-7. Epub 2017 Aug 14.
    b Department of Prevention and Control for Occupational Disease , Jiangsu Provincial Center for Disease Prevention and Control , Nanjing , Jiangsu , China.
    Context: Acute or chronic exposure of N,N-dimethylacetamide (DMAc) is responsible for abnormal liver function. It appears that DMAc is mainly metabolized by cytochrome P450 in the liver and thereby produces reactive oxygen species (ROS). The elimination of ROS and the repairing of ROS-induced DNA damage are relevant to the ultimate toxicity of DMAc. Read More

    Biochemical alterations induced by nickel oxide nanoparticles in female Wistar albino rats after acute oral exposure.
    Biomarkers 2017 Aug 10:1-11. Epub 2017 Aug 10.
    a Toxicology Unit, Pharmacology and Toxicology Division , CSIR-Indian Institute of Chemical Technology , Hyderabad , India.
    Context: Nickel oxide (NiO) nanoparticles (NPs) with appropriate surface chemistry have been widely used for their potential new applications in biomedical industry. Increased usage of these NPs enhances the chance of exposure of personnel involved in the work place.

    Objective: This study was designed to assess the ability of NiO NPs to cause biochemical alterations post-acute oral exposure in female Wistar rats. Read More

    Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.
    Biomarkers 2017 Sep 26;22(6):584-593. Epub 2017 Jul 26.
    a Department of Preventive Medicine , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
    Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear.

    Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Read More

    Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients.
    Biomarkers 2017 Dec 20;22(8):790-797. Epub 2017 Jul 20.
    d Department of Physiology and Immunology , University of Rijeka , Rijeka , Croatia.
    Background: Suitable biomarkers that have prognostic values are one of the key points of interest in ischaemic stroke. Increased sympathetic nervous system activity in ischaemic stroke causes multiple local and systemic effects that can be detrimental to the outcome. The mechanism of action is increased secretion and activity of catecholamines, whose end metabolic products are vanillylmandelic acid and homovanilic acid. Read More

    Differential expression of circulating vascular cell adhesion molecule-1 in subjects with coronary artery disease and cardiac syndrome X without known diabetes mellitus.
    Biomarkers 2017 Dec 18;22(8):798-804. Epub 2017 Jul 18.
    b School of Medicine , National Yang Ming University , Taipei , Taiwan.
    Context: Inflammation is one of the mechanisms underlying cardiac syndrome X (CSX).

    Objectives: Few studies have compared the expression of inflammatory or adhesion molecules between coronary artery disease (CAD) versus CSX.

    Materials And Methods: Ninety-two CSX and 145 CAD subjects without known diabetes mellitus underwent coronary angiogram for angina. Read More

    Mutation in the beta3 subunit of Guanine nucleotide-binding protein (GNB3) gene is not associated with Type II diabetes mellitus risk: a case-control study of a North Indian population.
    Biomarkers 2017 Dec 11;22(8):782-789. Epub 2017 Jul 11.
    a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
    Context: Genetics play a major role in development and pathophysiology of Type 2 diabetes mellitus (T2DM).

    Objective: To asses the association of Guanine nucleotide-binding protein (GNB3) (C825T) gene's polymorphism with T2DM.

    Materials And Methods: A case-control study including 400 North Indians was performed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) approach to analyze genetic polymorphism. Read More

    P-gp expression levels in the erythrocytes of brown trout: a new tool for aquatic sentinel biomarker development.
    Biomarkers 2017 Sep 19;22(6):566-574. Epub 2017 Jun 19.
    a Université Clermont Auvergne, Institut Universitaire de Technologie de Clermont-Fd INSERM, UMR 1240 Imagerie Moléculaire et Stratégies Théranostiques , Clermont Ferrand , France.
    Context: P-glycoprotein (P-gp) is a ubiquitous membrane detoxification pump involved in cellular defence against xenobiotics. Blood is a hub for the trade and transport of physiological molecules and xenobiotics. Our recent studies have highlighted the expression of a 140-kDa P-gp in brown trout erythrocytes in primary cell culture and its dose-dependent response to Benzo[a]pyrene pollutant. Read More

    Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review.
    Biomarkers 2017 Sep 21;22(6):489-501. Epub 2017 Jun 21.
    a Department of Epidemiology and Environmental Health, School of Public Health and Health Professions , The State University of New York (SUNY) at Buffalo , Buffalo , NY , USA.
    Purpose: This review focuses on studies among pregnant women that used biomarkers to assess air pollution exposure, or to understand the mechanisms by which it affects perinatal outcomes.

    Methods: We searched PubMed and Google scholar databases to find articles.

    Results And Conclusions: We found 29 articles, mostly consisting of cohort studies. Read More

    Methionine metabolism and multiple sclerosis.
    Biomarkers 2017 Dec 6;22(8):747-754. Epub 2017 Jun 6.
    a Institute of Medical Chemistry, Biochemistry, and Clinical Chemistry, Faculty of Medicine, Comenius University , Bratislava , Slovakia.
    Context: Methylation reactions are particularly important in the brain and their inhibition can lead to a number of serious pathologies. Multiple sclerosis is one of the most common neurological disorders caused by interaction of genetic and environmental factors, but little is known about its cause or factors that contribute to the disorder. Although multiple sclerosis is primarily regarded as demyelinating disorder, there are no many articles focusing on methionine determination. Read More

    A simple point of care test can indicate the need for periodontal therapy to reduce the risk for adverse pregnancy outcomes in mothers attending antenatal clinics.
    Biomarkers 2017 Dec 6;22(8):740-746. Epub 2017 Jun 6.
    a Department of Medical Biosciences , University of the Western Cape , Bellville , Cape Town , South Africa.
    Introduction: Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine-2-naphthylamide), a diagnostic test for PD, may inform obstetricians and other antenatal healthcare practitioners, of the risk of adverse pregnancy outcomes in mothers attending antenatal clinics.

    Methods: At first visit, the presence of suspected periodontopathogens was assessed by BANA testing of dental plaque from 443 mothers attending antenatal clinics in KwaZulu-Natal, South Africa and an association later sought with pregnancy outcomes. Read More

    Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.
    Biomarkers 2017 Jun 6:1-5. Epub 2017 Jun 6.
    a Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences , Universiti Putra Malaysia , Serdang , Selangor , Malaysia.
    Context: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin. Read More

    Head-to-head comparison of cardiac troponin T and troponin I in patients without acute coronary syndrome: a systematic review.
    Biomarkers 2017 Dec 9;22(8):701-708. Epub 2017 Jun 9.
    a Department of Cardiology , Herlev-Gentofte Hospital , Copenhagen , Denmark.
    Background: Cardiac-specific troponin T (cTnT) and troponin I (cTnI) are considered diagnostically equal in patients with acute coronary syndrome (ACS). The aim of this systematic review was to compare the prevalence and prognostic strength of elevations of cTnT and cTnI in patients with other conditions than ACS.

    Methods: A systemic review was conducted in concordance with the PRISMA guidelines. Read More

    High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study.
    Biomarkers 2017 Dec 14;22(8):709-714. Epub 2017 Jun 14.
    q Uppsala Clinical Research Center , Uppsala University , Uppsala , Sweden.
    Purpose: To describe the baseline, 1 hr and delta high sensitivity cardiac troponin (hs-cTnT) values in patients with suspected acute myocardial infarction (AMI) but without a final acute coronary syndrome (ACS) diagnosis.

    Materials And Methods: hs-cTnT assay for RAPID rule out of acute myocardial infarction (TRAPID-AMI) was a prospective diagnostic trial that enrolled emergency department (ED) patients with suspected AMI. Final patient diagnoses were adjudicated by a clinical events committee and subjects placed in different clinical groups: AMI, unstable angina, non-ACS cardiac, non-cardiac and unknown origin. Read More

    The adipokine tartrate-resistant acid phosphatase 5a in serum correlates to adipose tissue expansion in obesity.
    Biomarkers 2017 Dec 8;22(8):764-774. Epub 2017 Jun 8.
    a Division of Pathology, Department of Laboratory Medicine , Karolinska Institutet, Karolinska University Hospital Huddinge , Stockholm , Sweden.
    Purpose: Tartrate-resistant acid phosphatase (TRAP) exists as two isoforms, 5a and 5b. TRAP 5a is elevated in adipose tissue of obese women, interacts with pre-adipocytes and is linked to insulin-sensitive hyperplastic obesity when overexpressed in mice. The aim of this study was to investigate the relation between serum TRAP 5a, adiposity indices and metabolic syndrome risk markers in lean and obese women, using a newly developed TRAP 5a-specific ELISA. Read More

    Association of GSTT1 null, XPD 751 CC and XPC 939 CC genotypes with increased levels of genomic damage among hospital pathologists.
    Biomarkers 2017 Sep 4;22(6):557-565. Epub 2017 May 4.
    a Department of Life Sciences and Systems Biology , University of Turin , Torino , Italy.
    Context: Hospital workers are at risk for genotoxic damage following occupationally exposure to xenobiotics. Pathologists are exposed to chemicals during their use in health care environments, particularly throughout inhalation of airborne agents, absorption through skin or contact with the patient's body fluids.

    Objective: We evaluated the level of genomic damage in a sample of 61 hospital pathologists (occupationally exposed to antineoplastic drugs and sterilizing agents) and 60 control subjects. Read More

    The GALA study: relationship between galectin-3 serum levels and short- and long-term outcomes of patients with acute heart failure.
    Biomarkers 2017 Dec 2;22(8):731-739. Epub 2017 May 2.
    a Emergengy Department , Hospital Clínic; "Emergencies: processes and pathologies" Research Group, IDIBAPS , Barcelona , Spain.
    Objective: We tested the hypothesis that early measurement of galectin-3 at the emergency department (ED) during an episode of acute heart failure (AHF) allows predicting short- and long-term outcomes.

    Methods: We performed an exploratory study including 115 patients consecutively diagnosed with AHF in a single ED. Clinical and analytical variables were recorded. Read More

    HSP72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity.
    Biomarkers 2017 Sep 19;22(6):548-556. Epub 2017 Apr 19.
    a Molecular Physiology Unit , Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , Mexico City , Mexico.
    Objective: To evaluate whether the urinary HSP72 levels (uHSP72) are a useful biomarker for early diagnosis of acute kidney injury (AKI) induced by two widely used drugs: cisplatin and acetaminophen.

    Materials And Methods: To analyze the time-course of nephrotoxic injury and uHSP72 levels, male Wistar rats were administered a single high dose of cisplatin (7 mg/kg) or acetaminophen (750 mg/kg) and were assessed at 6, 12, 24, 48, 72, 96 and 120 h.

    Results: AKI induced by cisplatin was characterized by tubular injury that started at 6 h and was enhanced after 48 h. Read More

    Elevated serum leptin levels are associated with low vitamin D, sarcopenic obesity, poor muscle strength, and physical performance in knee osteoarthritis().
    Biomarkers 2017 Dec 19;22(8):723-730. Epub 2017 Apr 19.
    a Department of Biochemistry, Faculty of Medicine , Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok , Thailand.
    Context: The associations between serum leptin, vitamin D status, sarcopenic obesity, muscle strength and physical performance in osteoarthritis (OA) remain uncertain.

    Objective: To analyse the relationships between serum leptin, vitamin D status, muscle strength and physical performance in OA patients.

    Methods: A total of 208 knee OA patients were enrolled. Read More

    Transcriptional variations in biomarkers of Mytilus galloprovincialis sampled from Central Adriatic coastal waters (Marche region, Italy).
    Biomarkers 2017 Sep 19;22(6):537-547. Epub 2017 Apr 19.
    a School of Biosciences and Veterinary Medicine, University of Camerino , Camerino , Italy.
    Objective: this work evaluates the expression of several biomarker genes (i.e. CAT, HSPs, MT10, p53, GSTpi, ER1/2) in Mytilus galloprovincialis native specimens to identify pollution related transcriptional changes. Read More

    Determination of air pollution-related biomarkers of exposure in urine of travellers between Germany and China using liquid chromatographic and liquid chromatographic-mass spectrometric methods: a pilot study.
    Biomarkers 2017 Sep 3;22(6):525-536. Epub 2017 Apr 3.
    a Cooperation Group Comprehensive Molecular Analytics, Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health GmbH , Neuherberg , Germany.
    Objective: The influence of different exposures to PM2.5 (particulate matter with an aerodynamic diameter below 2.5 μm) on the concentrations of biomarkers of exposure and oxidative stress should be investigated. Read More

    The value of microparticles in detecting acute rejection episodes after liver transplantation.
    Biomarkers 2017 Apr 3:1-8. Epub 2017 Apr 3.
    a Department of Surgery , Campus Charité Mitte | Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin , Berlin , Germany.
    Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.

    Objective: We analyzed the correlation of plasma microparticle levels (MP) with AR.

    Materials And Methods: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation. Read More

    Using multiple biomarkers and determinants to obtain a better measurement of oxidative stress: a latent variable structural equation model approach.
    Biomarkers 2017 Sep 29;22(6):517-524. Epub 2017 Mar 29.
    a Department of Epidemiology, Rollins School of Public Health , Emory University , Atlanta , GA , USA.
    Purpose: Since oxidative stress involves a variety of cellular changes, no single biomarker can serve as a complete measure of this complex biological process. The analytic technique of structural equation modeling (SEM) provides a possible solution to this problem by modelling a latent (unobserved) variable constructed from the covariance of multiple biomarkers.

    Methods: Using three pooled datasets, we modelled a latent oxidative stress variable from five biomarkers related to oxidative stress: F2-isoprostanes (FIP), fluorescent oxidation products, mitochondrial DNA copy number, γ-tocopherol (Gtoc) and C-reactive protein (CRP, an inflammation marker closely linked to oxidative stress). Read More

    The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens.
    Biomarkers 2017 Nov 28;22(7):689-697. Epub 2017 Feb 28.
    d Departments of Obstetrics/Gynaecology, Physiology, and Pathology , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
    Context: Clinical study of breast cancer patients in Chicago, IL, USA.

    Objective: Ascertain the utility of measurements of single-strand breaks (SSB) in DNA for assessment of breast cancer risk.

    Methods: Fine-needle aspirates of the breast, SSB by nick translation, percent breast density (PBD), Gail model risk, cumulative methylation index (CMI), enzymes of DNA repair and tissue antioxidants. Read More

    miR-200b-3p in plasma is a potential diagnostic biomarker in oral squamous cell carcinoma.
    Biomarkers 2017 Feb 15:1-5. Epub 2017 Feb 15.
    b Department of Ear-Nose-Throat , The Second People's Hospital of Huai'An , Jiangsu , China.
    Context: Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour.

    Objective: Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC).

    Materials And Methods: miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls. Read More

    Prognostic prediction in acute heart failure patients with extreme BNP values.
    Biomarkers 2017 Dec 15;22(8):715-722. Epub 2017 Feb 15.
    a Department of Internal Medicine , Centro Hospitalar São João , Portugal.
    Background: Some patients have good prognosis despite elevated B-type natriuretic peptide (BNP), while others have ominous outcome with low BNP. We aimed at characterising these groups of patients.

    Methods: We analysed patients prospectively included in an acute HF registry. Read More

    Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis.
    Biomarkers 2017 May - Jun;22(3-4):200-209. Epub 2017 Feb 14.
    b Neurovascular Research Laboratory , Vall d'Hebron University Hospital Research Institute (VHIR), Universitat Autònoma de Barcelona , Barcelona , Spain.
    Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes.

    Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes.

    Methods: We systematically reviewed the literature (sources: MEDLINE, web-based register http://stroke-biomarkers. Read More

    Comparison of urinary aflatoxin M1 and aflatoxin albumin adducts as biomarkers for assessing aflatoxin exposure in Tanzanian children.
    Biomarkers 2017 Feb 20:1-6. Epub 2017 Feb 20.
    e LICAMM , School of Medicine, University of Leeds , Leeds, United Kingdom.
    Purpose: To determine levels of urinary aflatoxin M1 (AFM1) in children and correlate the concentrations with previously reported aflatoxin albumin adduct (AF-alb) levels in these children.

    Materials And Methods: Matched urine and blood samples were collected from 84 Tanzanian children aged 6-14 months old. From 31 children in one village (Kigwa), samples were collected at three time points six months apart. Read More

    The role of urinary KIM-1, NGAL, CA19-9 and β2-microglobulin in the assessment of ureteropelvic junction obstruction in adults.
    Biomarkers 2017 Nov 8;22(7):682-688. Epub 2017 Feb 8.
    a Division of Urology, Hospital das Clinicas , University of Sao Paulo Medical School , Sao Paulo , Brazil.
    Purpose: The objective of this study is to evaluate the diagnostic properties of urinary biomarkers in adults with ureteropelvic junction obstruction: KIM-1, NGAL, CA19-9, and β2-microglobulin. We also assessed urinary biomarker concentrations following pyeloplasty.

    Material And Methods: We prospectively studied adults from December 2013 to February 2015. Read More

    Recent advances in molecular biomarkers for diabetes mellitus: a systematic review.
    Biomarkers 2017 Nov 24;22(7):604-613. Epub 2017 Jan 24.
    a Neuroscience Research Unit , School of Life Sciences, Faculty of Science, University of Technology Sydney , Broadway , NSW , Australia.
    Context: Diabetes is a growing global metabolic epidemic. Current research is focussing on exploring how the biological processes and clinical outcomes of diabetes are related and developing novel biomarkers to measure these relationships, as this can subsequently improve diagnostic, therapeutic and management capacity.

    Objective: The objective of this study is to identify the most recent advances in molecular biomarkers of diabetes and directions that warrant further research. Read More

    H19 non-coding RNA in urine cells detects urothelial carcinoma: a pilot study.
    Biomarkers 2017 Nov 22;22(7):661-666. Epub 2017 Mar 22.
    c Nephrology and Hypertension Services , Hadassah - Hebrew University Medical Centre , Jerusalem , Israel.
    Context: Urothelial carcinoma (UC) is common and highly recurrent. Diagnosis and follow-up involve invasive cystoscopies.

    Objective: To evaluate H19 RNA in urine cells as diagnostic tool for UC. Read More

    Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy.
    Biomarkers 2017 May - Jun;22(3-4):367-371. Epub 2017 Jan 24.
    a Department of Cardiology , Oslo University Hospital , Rikshospitalet , Oslo , Norway.
    Purpose: Diagnostic and prognostic evaluation remains challenging in arrhythmogenic right ventricular cardiomyopathy (ARVC). We measured plasma concentration of soluble ST2 (sST2) and assessed its association with right ventricular (RV) function and ventricular arrhythmias in patients with ARVC.

    Methods: We included patients with ARVC and genotype positive relatives. Read More

    Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study.
    Biomarkers 2017 May - Jun;22(3-4):361-366. Epub 2017 Jan 25.
    j Deparment of General Medicine and Primary Care , Beth Israel Deaconess Medical Center , Boston , United States.
    Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.

    Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.

    Materials And Methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Read More

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