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    Proenkephalin and risk of developing chronic kidney disease: the Prevention of Renal and Vascular End-stage Disease study.
    Biomarkers 2018 Feb 22:1-30. Epub 2018 Feb 22.
    a University of Groningen, University Medical Center Groningen, Department of Internal Medicine , Groningen , the Netherlands.
    Background: Proenkephalin (pro-ENK) was recently found to be associated with low eGFR. The association of pro-ENK with urinary albumin excretion (UAE), another marker for CKD, has not been investigated. We examined the association of pro-ENK with eGFR and UAE as a markers of CKD. Read More

    Prognostic and diagnostic value of elevated serum concentration of procalcitonin in patients with suspected heart failure. A Review and Meta-Analysis.
    Biomarkers 2018 Feb 21:1-22. Epub 2018 Feb 21.
    a Department of Cardiology , Avicenne Hospital, Hopitaux Universitaires Paris-Seine-Saint-Denis, APHP, Paris XIII University , France.
    Purpose: The diagnostic and prognostic significance of procalcitonin remains uncertain in HF patients. We reviewed and performed a meta-analysis of studies that measured PCT in HF patients, with or without infection.

    Materials And Methods: We identified 7 studies (9,514 patients, 5,810 with diagnoses of HF) eligible for our analysis, out of 247 examined. Read More

    Revised and extended serum cotinine cut offs to classify smokers and nonsmokers.
    Biomarkers 2018 Feb 21:1-20. Epub 2018 Feb 21.
    a Independent Researcher , Dacula , GA , USA.
    Purpose: To revise and extend the previously published serum cotinine cut offs to classify smokers and nonsmokers for US adolescents and adults.

    Materials And Methods: Cross-sectional data (N = 10171) from National Health and Nutrition Examination Survey for 2011-2014 were used to compute serum cotinine cut offs to classify smokers and nonsmokers for US adults aged > = 20 years and 2007-2014 (N = 4583) data were used to compute serum cotinine cut offs for US adolescents aged 12 - 19 years.

    Results: Specificities and sensitivities for the cut offs among adults were > = 95% and > = 75% among adolescents. Read More

    Long non-coding RNA FENDRR reduces prostate cancer malignancy by competitively binding miR-18a-5p with RUNX1.
    Biomarkers 2018 Feb 21:1-26. Epub 2018 Feb 21.
    b The Second Department of Urinary Surgery , The First Affiliated Hospital of Xinxiang Medical University , Weihui 453100 , Henan , China.
    Context: Prostate cancer (PCa) is one of the most commonly diagnosed malignancy in men in the western world.

    Objective: We aim to investigate the biological role of long non-coding RNA FENDRR and its mechanism in PCa.

    Materials And Methods: We determined the expression of FENDRR and miR-18a-5p in PCa tissues and examined the regulatory mechanism in PCa cell lines. Read More

    Reconsidering the relation between serum homocysteine and red blood cell distribution width - A cross sectional study of a large cohort.
    Biomarkers 2018 Feb 20:1-12. Epub 2018 Feb 20.
    a Department of Internal Medicine F-Recanati , Rabin Medical Center, Beilinson Hospital , Petah Tikva , Israel.
    Purpose: In a recent small sample study, red blood cell distribution width (RDW) was suggested as a predictor of homocysteine levels. The current study we aimed to reexamine this association in a large scale sample.

    Methods: A retrospective cross-sectional study of healthy adults, conducted at Rabin Medical Center, during 2000-2014. Read More

    Identification of potential 'Lifestyle-responsive' epigenomic biomarkers in healthy women aged 18-40.
    Biomarkers 2018 Feb 20:1-16. Epub 2018 Feb 20.
    c NZGL, University of Otago , Dunedin , New Zealand.
    Context: Human health is complex and multifaceted; there is a need for biomarkers that reflect the multidimensional nature of health.

    Objective: To identify potential epigenomic biomarkers of health in women aged 18-40 participating in a 6 month lifestyle intervention, Next Level Health.

    Materials And Methods: Methylation data were obtained by Reduced Representation Bisulfite Sequencing of 21 women intervention participants as well as 3 non-participants. Read More

    Comparative study of nano and bulk FeOinduced oxidative stress in Wistar rats.
    Biomarkers 2018 Feb 19:1-27. Epub 2018 Feb 19.
    a Toxicology Unit, Pharmacology and Toxicology Division , Indian Institute of Chemical Technology , Hyderabad - 500007 , India.
    Context: Magnetic nanomaterials (FeONMs) have become novel tools with multiple biological and medical applications because of their biocompatibility. However, adverse health effects of these NMs are of great interest to learn.

    Objective: This study was designed to assess the size and dose dependant effects of FeONMs and its bulk on oxidative stress biomarkers after post-subacute treatment in female wistar rats. Read More

    Serum creatine is not a reliable marker of muscular fitness in young adults.
    Biomarkers 2018 Feb 19:1-3. Epub 2018 Feb 19.
    a Faculty of Sport and Physical Education , University of Novi Sad , Novi Sad , Serbia.
    Purpose: Elevated serum creatine and higher handgrip strength are individually associated with better health profiles yet the link between two variables remains unknown. In this cross-sectional study, we evaluated serum creatine levels in relation to handgrip strength in a cohort of 130 young healthy adults (61 women and 69 men; age 23.3 ± 2. Read More

    Verification of a proteomic biomarker panel to diagnose minor stroke and transient ischaemic attack: phase 1 of SpecTRA, a large scale translational study.
    Biomarkers 2018 Feb 12:1-14. Epub 2018 Feb 12.
    i Department of Biochemistry and Microbiology , University of Victoria , Victoria , BC , Canada.
    Objective: To derive a plasma biomarker protein panel from a list of 141 candidate proteins which can differentiate transient ischaemic attack (TIA)/minor stroke from non-cerebrovascular (mimic) conditions in emergency department (ED) settings.

    Design: Prospective clinical study (#NCT03050099) with up to three timed blood draws no more than 36 h following symptom onset. Plasma samples analysed by multiple reaction monitoring-mass spectrometry (MRM-MS). Read More

    Intra-individual variation of miRNA expression levels in human plasma samples.
    Biomarkers 2018 Jan 30:1-8. Epub 2018 Jan 30.
    a Department of Medicine, Division of Epidemiology , Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine , Nashville , TN , USA.
    Background: Circulating miRNAs as potential non-invasive biomarkers for disease risk assessment and cancer early diagnosis have attracted increasing interest. Little information, however, is available regarding the intra-individual variation of circulating miRNA levels.

    Methods: We measured expression levels of a panel of 800 miRNAs in repeated plasma samples from 51 healthy individuals that were collected 6 to 12 months apart and evaluated the intra-individual variation by the intra-class correlation coefficient (ICC). Read More

    Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease.
    Biomarkers 2018 Feb 12:1-8. Epub 2018 Feb 12.
    a Department of Medicin e, D ivision of Pulmonary Medicine , Keio University School of Medicine , Tokyo , Japan.
    Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Read More

    Association between gestational diabetes and biomarkers: a role in diagnosis.
    Biomarkers 2018 Feb 6:1-6. Epub 2018 Feb 6.
    e Department of Internal Medicine , University of Pretoria , Arcadia , South Africa.
    Background: We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM.

    Methods: In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM. Read More

    Enalapril decreases rat plasma concentration of TMAO, a gut bacteria-derived cardiovascular marker.
    Biomarkers 2018 Feb 7:1-6. Epub 2018 Feb 7.
    a Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research , Medical University of Warsaw , Warsaw , Poland.
    Introduction: Increased plasma level of trimethylamine N-oxide (TMAO), a bacterial metabolite of choline, is associated with an increased cardiovascular risk. Indoxyl sulfate, a bacterial metabolite of tryptophan, is thought to be associated with higher mortality in cardiorenal syndrome. We hypothesized that enalapril, a well-established drug reducing cardiovascular mortality, may affect the plasma level of gut bacteria-derived metabolites and gut bacteria composition. Read More

    YKL-40 in Patients with End Stage Renal Disease receiving Hemodialysis.
    Biomarkers 2018 Jan 23:1-28. Epub 2018 Jan 23.
    a Department of Cardiology , Herlev Hospital University of Copenhagen , Copenhagen , Denmark.
    Purpose: This study aimed to determine serum YKL-40 in patients with end stage renal disease (ESRD) on hemodialysis (HD) and to evaluate the prognostic value of serum YKL-40.

    Methods: Patients >18 years on maintenance HD were included. Serum YKL-40 was measured using ELISA before and after a single HD treatment. Read More

    NTproBNP and ST2 as predictors for all-cause and cardiovascular mortality in elderly patients with symptoms suggestive for heart failure.
    Biomarkers 2018 Feb 6:1-7. Epub 2018 Feb 6.
    a Research Unit, Department of Medicine , Skellefteå Hospital , Skellefteå , Sweden.
    Background: A new biomarker, suppression of tumorigenicity 2 (ST2) has been introduced as a marker for fibrosis and hypertrophy. Its clinical value in comparison with N-terminal pro-hormone of brain natriuretic peptide /Amino-terminal pro-B-type natriuretic peptide (NTproBNP) in predicting mortality in elderly patients with symptoms of heart failure (HF) is still unclear.

    Aim: To evaluate the prognostic value for all-cause- and cardiovascular mortality of ST2 or NTproBNP and the combination of these biomarkers. Read More

    The association between micronucleus, nucleoplasmic bridges, and nuclear buds frequency and the degree of uterine cervical lesions.
    Biomarkers 2018 Jan 31:1-9. Epub 2018 Jan 31.
    d Department of Biology, Faculty of Natural Sciences , University of Prishtina , Prishtina , Kosovo.
    Background And Aim: The loss of genomic stability plays an important role in carcinogenesis. Therefore, it is imperative to use certain biomarkers of DNA damage due to genomic instability in order to predict cancer risk. The aim of this study was the evaluation of genomic instability in patients with cervical lesions. Read More

    Evolving concepts and use of immunohistochemical biomarkers in flat non-neoplastic urothelial lesions: WHO 2016 classification update with diagnostic algorithm.
    Biomarkers 2018 Jan 25:1-10. Epub 2018 Jan 25.
    d Department of Urology and Renal Transplantation , University of Foggia , Foggia , Italy.
    Context: The classification of flat non-neoplastic urothelial lesions has been evolved through the years in the attempt to better define a spectrum of morphologic entities with somewhat overlapping features. Differentiating these lesions is important because of differences in patient management and clinical outcome. Materials and methods and objective: A systematic review of the literature has been carried out in order to (1) assess the most striking clinical features of each lesion and (2) identify those morphological traits and immunophenotypical markers which may aid in the differential diagnosis. Read More

    Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis.
    Biomarkers 2018 Jan 31:1-10. Epub 2018 Jan 31.
    a Laboratoire de Procédés de Criblage Moléculaire et Cellulaire, Centre de Biotechnologie de Sfax , Université de Sfax , Sfax , Tunisie.
    Context: Presbycusis, an age-related hearing impairment (ARHI), represents the most common sensory disability in adults. Today, the molecular mechanisms underlying presbycusis remain unclear. This is in particular due to the fact that ARHI is a multifactorial complex disorder resulting from several genomic factors interacting with lifelong cumulative effects of: disease, diet, and environment. Read More

    New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease.
    Biomarkers 2018 Jan 19:1-7. Epub 2018 Jan 19.
    c Department of Diagnostic Pathology , Kurume University Hospital , Kurume, Fukuoka , Japan.
    Purpose: To establish a new scoring system as a noninvasive tool for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).

    Methods: A total of 170 patients histologically diagnosed with nonalcoholic steatohepatitis (NASH) (n = 130) or nonalcoholic fatty liver (NAFL) (n = 40) were enrolled. We analyzed receiver operating characteristic (ROC) curves and performed multivariate analysis to predict steatohepatitis and liver fibrosis. Read More

    Role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) in assessing disease control in Asian patients with axial spondyloarthritis.
    Biomarkers 2018 Jan 24:1-4. Epub 2018 Jan 24.
    a Duke-NUS Medical School , Singapore.
    Introduction: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) which are used for assessment of axial spondyloarthritis (AxSpA) related disease activity have poor specificity and sensitivity. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) have not been investigated as disease activity markers among Asian AxSpA patients.

    Methodology: A retrospective, cross-sectional study was conducted in Singapore General Hospital from January 2013 to December 2015 to investigate the role of NLR, PLR and MPV as disease activity markers in AxSpA patients. Read More

    Determinants of elevated carbohydrate antigen 125 in patients with severe symptomatic aortic valve stenosis referred for transcatheter aortic valve implantation.
    Biomarkers 2018 Jan 15:1-6. Epub 2018 Jan 15.
    a Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München , Munich , Germany.
    Purpose: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after transcatheter aortic valve implantation (TAVI). While known underlying pathophysiological mechanisms of elevated CA125 include serosal effusions and inflammatory stimuli, clinical determinants associated with elevated CA125 in patients referred for TAVI remain unknown. Therefore, we investigated clinical, laboratory and echocardiographic determinants of elevated CA125 in patients with severe aortic valve stenosis referred for TAVI. Read More

    Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products.
    Biomarkers 2018 Jan 9:1-32. Epub 2018 Jan 9.
    d Research & Development , Philip Morris International , Neuchâtel , Switzerland.
    Context: One approach to reducing the harm caused by cigarette smoking, at both individual and population level, is to develop, assess and commercialize modified risk alternatives that adult smokers can switch to. Studies to demonstrate the exposure and risk reduction potential of such products generally involve the measuring of biomarkers, of both exposure and effect, sampled in various biological matrices.

    Objective: In this review, we detail the pros and cons for using several biomarkers as indicators of effects of changing from conventional cigarettes to modified risk products. Read More

    How is the relationship between TWIST-1 and BCR-ABL1 gene expressions in chronic myeloid leukaemia patients?
    Biomarkers 2018 Jan 12:1-6. Epub 2018 Jan 12.
    a Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
    Background: The activation and increased expression of BCR-ABL1 lead to malignant chronic myelogenous leukaemia (CML) cells, as well as the resistance to antitumour agents and apoptosis inducers. Moreover, TWIST-1 protein is a prognostic factor of leukemogenesis, and its level is raised in CML patients with cytogenetic resistance to imatinib. So, there is a likely relationship between BCR-ABL1 and TWIST-1 genes. Read More

    Exosomal small RNA sequencing uncovers the microRNA dose markers for power frequency electromagnetic field exposure.
    Biomarkers 2018 Jan 11:1-13. Epub 2018 Jan 11.
    c Department of Radiation Medicine, School of Public Health, Guangdong Provincial Key Laboratory of Tropical Disease Research , Southern Medical University , Guangzhou , PR China.
    Purpose: The potential health risks caused by power frequency electromagnetic field (PFEMF) have led to increase public health concerns. However, the diagnosis and prognosis remain challenging in determination of exact dose of PFEMF exposure.

    Materials And Methods: Mice were exposed to different magnetic doses of PFEMF for the following isolation of serum exosomes, microRNAs (miRNAs) extraction and small RNA sequencing. Read More

    MicroRNAs as possible biomarkers for screening of aortic aneurysms: a systematic review and validation study.
    Biomarkers 2018 Jan 15:1-12. Epub 2018 Jan 15.
    a Cyprus School of Molecular Medicine , The Cyprus Institute of Neurology and Genetics , Nicosia , Cyprus.
    Context: There is an urgent need to identify non-invasive biomarkers for the early detection of aortic aneurysms, preceding a fatal event. The potential role for MicroRNAs (miRNAs) as diagnostic markers for aortic aneurysms was investigated through the present systematic review.

    Objective: To perform a comprehensive review on published studies examining the association of miRNAs with aortic aneurysms and further validate these results with plasma samples collected from thoracic aortic aneurysm (TAA) patients. Read More

    Diagnostic accuracy of MALDI-TOF mass spectrometry for non-small cell lung cancer: a meta-analysis.
    Biomarkers 2018 Jan 12:1-8. Epub 2018 Jan 12.
    b Department of Laboratory Medicine , General Hospital of Jinan Military Command Region , Jinan , China.
    Objective: To assess the overall accuracy of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in identifying non-small cell lung cancer (NSCLC).

    Methods: A comprehensive search of PubMed, EMBASE and CNKI databases as well as the reference lists from relevant articles was performed prior to July 2017. Two authors independently screened articles based on inclusion and exclusion criteria and assessed the quality of each study using the Quality Assessment of Diagnostic Accuracy Studies 2 (QADAS-2) tool. Read More

    Rationale and design of the IMPACT EU-trial: improve management of heart failure with procalcitonin biomarkers in cardiology (BIC)-18.
    Biomarkers 2018 Feb 8;23(1):97-103. Epub 2018 Jan 8.
    e Coronary Care Unit and Heart Failure Program, Veterans Affairs San Diego Healthcare System , UCSan Diego School of Medicine , San Diego , CA , USA.
    Objectives: To evaluate the effectiveness of procalcitonin (PCT)-guided antibiotic treatment compared to current treatment practice to reduce 90-day all-cause mortality in emergency patients with shortness of breath (SOB) and suspected acute heart failure (AHF).

    Background: Concomitant AHF and lower respiratory tract (or other bacterial) infection in emergency patients with dyspnea are common and can be difficult to diagnose. Early and adequate initiation of antibiotic therapy (ABX) significantly improves patient outcome, but superfluous prescription of ABX maybe harmful. Read More

    Association of low-dose exposure to persistent organic pollutants with E-cadherin promoter methylation in healthy Koreans.
    Biomarkers 2018 Jan 5:1-6. Epub 2018 Jan 5.
    a Department of Anatomy, BK21 Plus KNU Biomedical Convergence Program, School of Medicine , Kyungpook National University , Daegu , Korea.
    Background: Persistent organic pollutants (POPs), despite their considerably low levels in humans, are an increasing concern for the general populations given their various adverse health problems, including metabolic and carcinogenic effects. DNA methylation deregulation is thought to be a key mechanism in the development of human chronic diseases including cancer.

    Methods: In an attempt to identify biomarkers monitoring low-dose exposure and hazard, we explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) may influence the methylation of tumour suppressor gene E-cadherin (CDH1) using peripheral blood cells from 364 healthy Korean subjects. Read More

    Serum paracetamol-protein adducts in ambulatory subjects: Relationship to recent reported paracetamol use.
    Biomarkers 2017 Dec 8:1-5. Epub 2017 Dec 8.
    a Rocky Mountain Poison and Drug Center , Denver Health and Hospitals , Denver , CO , USA.
    Context: Serum paracetamol-protein adducts (PPAs) are a novel potential biomarker of paracetamol exposure. The relationship between serum PPA concentrations and reported paracetamol use in ambulatory adults has not been previously described.

    Materials And Methods: This was a cross-sectional study of ambulatory adults. Read More

    De-novo identification of specific exposure biomarkers of the alternative plasticizer di(2-ethylhexyl) terephthalate (DEHTP) after low oral dosage to male volunteers by HPLC-Q-Orbitrap-MS.
    Biomarkers 2018 Mar 4;23(2):196-206. Epub 2018 Jan 4.
    a Institute for Prevention and Occupational Medicine of the German Social Accident Insurance , Institute of the Ruhr-Universität Bochum (IPA) , Bochum , Germany.
    Context: Human exposure biomonitoring relies on the availability of specific, sensitive biomarkers. For emerging chemicals, the identification (prediction, synthesis, verification) of such biomarkers is time and cost intensive.

    Objective: This study aimed to further elucidate the urinary metabolic profile of the plasticizer di(2-ethylhexyl) terephthalate (DEHTP) in search of probably additional biomarkers of exposure. Read More

    Histopathological indices and inflammatory response in the digestive gland of the mussel Mytilus galloprovincialis as biomarker of immunotoxicity to silver nanoparticles.
    Biomarkers 2017 Dec 11:1-11. Epub 2017 Dec 11.
    a Research Unit of Immuno-Microbiology Environmental and Cancerogensis, Sciences Faculty of Bizerte , University of Carthage , Tunisia.
    Background: Histopathological assessments approaches in bivalves have become an important tool in environmental toxicology. This study seeks to develop a quantitative histopathological index (Ih) and inflammation score as biomarkers in the aim to assess the health status of nanoparticles exposed mussels.

    Methods: Digestive gland hematoxylin and eosin (H&E) stained sections from Mytilus galloprovincialis were assessed after in vivo exposure (for 3, 6 and 12 h) to silver nanoparticles (Ag-NPs < 50 nm and Ag-NPs < 100 nm) prior and after manipulating the potential uptake pathways (clathrin- and caveolae-mediated endocytosis) using amantadine and nystatin as blockers. Read More

    Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.
    Biomarkers 2018 Feb 16;23(1):1-9. Epub 2017 Nov 16.
    d VA Eastern Colorado Healthcare System and Division of Cardiology , University of Colorado , Denver , CO , USA.
    Aim: Novel biomarkers have been proposed for identification of patients at greater risk of future adverse events among those presenting with chest pain. In this review, we aim to elucidate the ability of pregnancy associated plasma protein-A (PAPP-A) to predict mortality and other cardiovascular events in this patient population.

    Methods: A literature search of the electronic databases Medline, Scopus, Cochrane Library and ClinicalTrials. Read More

    Alteration of salivary glycopatterns in oral lichen planus.
    Biomarkers 2018 Mar 27;23(2):188-195. Epub 2017 Nov 27.
    a Department of Immunology , the Fourth Military Medical University , Xi'an , China.
    Background: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5-2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Read More

    Podocyturia as an early diagnostic marker of preeclampsia: a literature review.
    Biomarkers 2017 Nov 27:1-6. Epub 2017 Nov 27.
    c Faculty of Chemistry , University of Wroclaw , Wroclaw , Poland.
    Context: Preeclampsia (PE) is a pregnancy-related disease, and it is a leading cause of maternal and neonatal morbidity and mortality. It is characterized by the new onset of hypertension after 20 weeks of gestation together with signs of organ damage, most commonly the kidneys. The treatment of PE is symptomatic and final intervention requires delivery, regardless of the gestational age of the foetus. Read More

    Can adipokines serum levels be used as biomarkers of hand osteoarthritis?
    Biomarkers 2017 Nov 22:1-6. Epub 2017 Nov 22.
    c Medicine and Rheumatology Unit , Rizzoli Orthopaedic Institute , Bologna , Italy.
    Purpose: To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC).

    Methods: 94 outpatients with E HOA and NE HOA and 21 NC were enrolled. The radiological assessment of both hands was performed according to the Kellgren-Lawrence and Kallman score. Read More

    Elevated serum lactate in emergency department patients predicts hospital admission unrelated to diagnosis - but not more.
    Biomarkers 2018 Feb 20;23(1):88-96. Epub 2017 Nov 20.
    a Department of Emergency Medicine , University Hospital Jena , Jena , Germany.
    Purpose: The value of lactate as a screening biomarker in the emergency department is debated. We analysed all unselected patients in the emergency department with serum lactate measured with regard to different outcome parameters.

    Material And Methods: In a retrospective single centre study, we analysed all digitalized patient data of a two-week period of all patients ≥18 where a serum lactate was measured. Read More

    Regulation of circulating chromogranin B levels in heart failure.
    Biomarkers 2018 Feb 7;23(1):78-87. Epub 2017 Nov 7.
    a Technische Universität Dresden , Heart Center Dresden University Hospital , Dresden , Germany.
    Background: Chromogranin B (CGB) regulates B-type natriuretic peptide (BNP) production. Circulating CGB levels are elevated in heart failure (HF) animal models and HF patients, but also increase in healthy individuals in response to physical activity. Therefore, CGB seems to integrate information from myocardial stress and systemic neuro-endocrine activation. Read More

    Characterization of organophosphate pesticides in urine and home environment dust in an agricultural community.
    Biomarkers 2018 Mar 5;23(2):174-187. Epub 2018 Jan 5.
    a Institute for Risk Analysis and Risk Communication , University of Washington , Seattle , WA , USA.
    Context: Organophosphorus insecticides (OPs) have been used to control agricultural pests found in Washington state. Farmworkers (FW) have higher exposure to OP pesticides than non-farmworkers (NFW), and FW children may in turn have higher exposure than NFW children.

    Objective: To examine the association between the concentration in house dust of five OPs used commonly in pome fruit orchards and the concentration in urine of dialkylphosphate metabolites (DAP), in a cohort of Hispanic FW and NFW and their children. Read More

    Biological monitoring of exposure to low concentrations of benzene in workers at a metallurgical coke production plant: new insights into S-phenylmercapturic acid and urinary benzene.
    Biomarkers 2018 Feb 16;23(1):70-77. Epub 2017 Oct 16.
    a Interdisciplinary Department of Medicine , Section of Occupational Medicine "E.C. Vigliani", University of Bari Aldo Moro , Bari , Italy.
    Context: Urinary S-phenylmercapturic acid (SPMA) and benzene (U-Ben) are usually measured at the end of the work shift (ES), although their kinetic of elimination is not clearly known.

    Objective: To investigate SPMA and U-Ben elimination 16 h after the ES, in 93 coke production workers exposed to low benzene concentrations.

    Materials And Methods: Airborne benzene (A-Ben) was measured by passive samplings, while SPMA, U-Ben, methyl-tert-butyl ether (U-MTBE), cotinine (U-Cot) and creatinine were determined on urine samples collected at ES and before the beginning of the next work shift (next BS). Read More

    The prognostic value of the furosemide stress test in predicting delayed graft function following deceased donor kidney transplantation.
    Biomarkers 2018 Feb 16;23(1):61-69. Epub 2017 Oct 16.
    a Division of Nephrology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
    Objectives And Methods: The Furosemide Stress Test (FST) is a novel dynamic assessment of tubular function that has been shown in preliminary studies to predict patients who will progress to advanced stage acute kidney injury, including those who receive renal replacement therapy (RRT). The aim of this study is to investigate if the urinary response to a single intraoperative dose of intravenous furosemide predicts delayed graft function (DGF) in patients undergoing deceased donor kidney transplant.

    Results: On an adjusted multiple logistic regression, a single 100 mg dose of intraoperative furosemide after the anastomosis of the renal vessels (FST) predicted the need for RRT at 2 and 6 h post kidney transplantation (KT). Read More

    Protective effect of Zizyphus lotus jujube fruits against cypermethrin-induced oxidative stress and neurotoxicity in mice.
    Biomarkers 2018 Mar 20;23(2):167-173. Epub 2017 Oct 20.
    a Faculte des Sciences de Bizerte , Universite de Carthage , Bizerte , Tunisia.
    Context: Cypermethrin (CYP) is a synthetic pyrethroid insecticide used worldwide in agriculture, home pest control. The toxicity of CYP is well studied in many organisms.

    Objective: The aim of present study was to investigate the protective effect of Zizyphus lotus (Zizyp) fruit against neurotoxicity and oxidative stress induced by CYP in mice. Read More

    Role of IL-1ra and Granzyme B as biomarkers in active Crohn's disease patients.
    Biomarkers 2018 Mar 16;23(2):161-166. Epub 2017 Oct 16.
    a Department of Medicine , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , South Korea.
    Background And Aim: Altered gene expression in intestinal mucosa is thought to contribute to inflammatory process in Crohn's disease (CD). The present study investigated changes in the expression of genes associated with gut inflammation in CD patients by RNA microarray to identify disease biomarkers.

    Methods: Microarray analysis was carried out in formalin-fixed, paraffin-embedded intestinal tissue specimens from six CD patients who underwent surgery without prior treatment and from two healthy control subjects. Read More

    Quantification of manganese and mercury in toenail in vivo using portable X-ray fluorescence (XRF).
    Biomarkers 2018 Mar 10;23(2):154-160. Epub 2017 Oct 10.
    a School of Health Sciences , Purdue University , West Lafayette , IN , USA.
    Background And Objective: Toenail is an advantageous biomarker to assess exposure to metals such as manganese and mercury. Toenail Mn and Hg are in general analyzed by chemical methods such as inductively coupled plasma mass spectrometry and atomic absorption spectrophotometry. In this project, a practical and convenient technology-portable X-ray florescence (XRF)-is studied for the noninvasive in vivo quantification of manganese and mercury in toenail. Read More

    Club cell protein (CC16) in plasma, bronchial brushes, BAL and urine following an inhaled allergen challenge in allergic asthmatics.
    Biomarkers 2018 Feb 18;23(1):51-60. Epub 2017 Sep 18.
    a Department of Clinical Sciences, Respiratory Medicine and Allergology , Lund University , Lund , Sweden.
    Background: Club cell protein (CC16) is a pneumoprotein secreted by epithelial club cells. CC16 possesses anti-inflammatory properties and is a potential biomarker for airway epithelial damage. We studied the effect of inhaled allergen on pulmonary and systemic CC16 levels. Read More

    Quantification of cotinine in dried blood spots as a biomarker of exposure to tobacco smoke.
    Biomarkers 2018 Feb 18;23(1):44-50. Epub 2017 Sep 18.
    a Department of Preventive Medicine, Feinberg School of Medicine , Northwestern University , Chicago , IL , USA.
    Objective: We present an ultra-sensitive, minimally-invasive method for quantifying cotinine in dried blood spot (DBS) samples as a biomarker of exposure to tobacco smoke that can be collected using a simple heel or finger prick to obtain blood samples.

    Methods: Cotinine levels were measured in matched plasma and reconstituted DBS samples from smokers and nonsmokers to evaluate assay parameters. In addition, we applied this new method to finger-prick DBS samples that were collected from infants, children and young adults ages 1-21 to estimate exposure to tobacco smoke. Read More

    Correlation between CAT polymorphism and susceptibility to DMAc-induced abnormal liver function: a case-control study of Chinese population.
    Biomarkers 2018 Mar 14;23(2):147-153. Epub 2017 Aug 14.
    b Department of Prevention and Control for Occupational Disease , Jiangsu Provincial Center for Disease Prevention and Control , Nanjing , Jiangsu , China.
    Context: Acute or chronic exposure of N,N-dimethylacetamide (DMAc) is responsible for abnormal liver function. It appears that DMAc is mainly metabolized by cytochrome P450 in the liver and thereby produces reactive oxygen species (ROS). The elimination of ROS and the repairing of ROS-induced DNA damage are relevant to the ultimate toxicity of DMAc. Read More

    Biochemical alterations induced by nickel oxide nanoparticles in female Wistar albino rats after acute oral exposure.
    Biomarkers 2018 Feb 10;23(1):33-43. Epub 2017 Aug 10.
    a Toxicology Unit, Pharmacology and Toxicology Division , CSIR-Indian Institute of Chemical Technology , Hyderabad , India.
    Context: Nickel oxide (NiO) nanoparticles (NPs) with appropriate surface chemistry have been widely used for their potential new applications in biomedical industry. Increased usage of these NPs enhances the chance of exposure of personnel involved in the work place.

    Objective: This study was designed to assess the ability of NiO NPs to cause biochemical alterations post-acute oral exposure in female Wistar rats. Read More

    Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.
    Biomarkers 2017 Sep 26;22(6):584-593. Epub 2017 Jul 26.
    a Department of Preventive Medicine , Northwestern University Feinberg School of Medicine , Chicago , IL , USA.
    Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear.

    Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Read More

    Values of vanillylmandelic acid and homovanillic acid in the urine as potential prognostic biomarkers in ischaemic stroke patients.
    Biomarkers 2017 Dec 20;22(8):790-797. Epub 2017 Jul 20.
    d Department of Physiology and Immunology , University of Rijeka , Rijeka , Croatia.
    Background: Suitable biomarkers that have prognostic values are one of the key points of interest in ischaemic stroke. Increased sympathetic nervous system activity in ischaemic stroke causes multiple local and systemic effects that can be detrimental to the outcome. The mechanism of action is increased secretion and activity of catecholamines, whose end metabolic products are vanillylmandelic acid and homovanilic acid. Read More

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