800,867 results match your criteria Biomarker Insights [Journal]


[Subjective memory impairments in early detection of dementia: Relation to acceptability of lumbar puncture in memory clinic patients].

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Vitos Klinikum Gießen-Marburg, Vitos Klinik für Psychiatrie und Psychotherapie Gießen; Fachbereich Medizin, Philipps-Universität Marburg.

Background: In memory clinics, biomarker-based diagnostic tools for early detection and differential diagnosis of dementia are increasingly important, even if their acceptance by patients is relatively low.

Objective: The aim of study was to examine whether sociodemographic and clinical features of memory clinic patients are associated with acceptance of lumbar puncture (LP). Of particular interest was the patients' self-perception of memory decline (subjective memory impairment, SMI) accompanied by related concerns that might affect decision to consent to LP. Read More

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December 2018

Expression Profiles of microRNAs in Drug-Resistant Non-Small Cell Lung Cancer Cell Lines Using microRNA Sequencing.

Cell Physiol Biochem 2018 Dec 17;51(6):2509-2522. Epub 2018 Dec 17.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou,

Background/aims: Drug resistance remains a main obstacle to the treatment of non- small cell lung cancer (NSCLC). The aim of this study was to identify the expression profiles of microRNAs (miRNAs) in drug-resistant NSCLC cell lines.

Methods: The expression profiles of miRNAs in drug-resistant NSCLC cell lines were examined using miRNA sequencing, and the common dysregulated miRNAs in these cell lines were identified and analyzed by bioinformatics methods. Read More

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December 2018

Improved ELISA for tumor marker detection using electro-readout-mode based on label triggered degradation of methylene blue.

Biosens Bioelectron 2018 Dec 7;126:800-805. Epub 2018 Dec 7.

Department of Chemistry, Capital Normal University, Beijing 100048, China. Electronic address:

Enzyme-linked immunosorbent assay (ELISA), a gold-standard method for protein detection, has been widely utilized in disease diagnosis. Nevertheless, the method is constrained by its dependence on a colorimetric readout that, due to its relatively low sensitivity, prevents its use in tumor marker detection. Here we demonstrate an ELISA that incorporates an electro-readout mode in place of a colorimetric readout to achieve ultrasensitive and convenient tumor marker detection. Read More

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December 2018
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A smart nanosensor for the detection of human immunodeficiency virus and associated cardiovascular and arthritis diseases using functionalized graphene-based transistors.

Biosens Bioelectron 2018 Dec 7;126:792-799. Epub 2018 Dec 7.

DBT-National Institute of Animal Biotechnology (DBT-NIAB), Hyderabad 500032, Telangana, India. Electronic address:

Human immunodeficiency virus (HIV), which isa worldwide public health issue, is commonly associated with cardiovascular disorders (CVDs) and rheumatoid arthritis (RA). A smart nanosensor was developed for the detection of HIV and its related diseases (CVDs and RA) using graphene-based field-effect transistors (FETs). In this study, amine-functionalized graphene (afG) was conjugated with antibodies [anti-p24 for HIV, anti-cardiac troponin 1 (anti-cTn1) for CVDs, and anti-cyclic citrullinated peptide (anti-CCP) for RA] to detect various biomarkers. Read More

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December 2018

Systematic review and meta-analysis of basal cortisol levels in Borderline Personality Disorder compared to non-psychiatric controls.

Psychoneuroendocrinology 2018 Dec 10;102:149-157. Epub 2018 Dec 10.

Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Australia.

Objective: Borderline personality disorder (BPD) is a prevalent, complex, and serious mental disorder involving multiple symptoms and maladaptive behaviour. The underlying psychobiological mechanisms involved are not yet fully understood, but increasing evidence indicates that changes in hypothalamic-pituitary-adrenal stress axis (HPA) activity may contribute to BPD. Whilst various studies have demonstrated elevated levels of cortisol (the end-product of the HPA axis) in BPD sufferers, others have presented opposite findings. Read More

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December 2018

Validation of the Hepatocellular Carcinoma Early detection Screening (HES) algorithm in a Cohort of Veterans with Cirrhosis.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Houston VA Health Services Research and Development Service Center of Excellence (Houston, TX), Section of Health Services Research, Michael E. DeBakey VA Medical Center (Houston, TX) and Baylor College of Medicine, Houston, TX. Electronic address:

Background & Aims: Early detection of hepatocellular carcinoma (HCC) through surveillance reduces mortality associated with this cancer. Guidelines recommend HCC surveillance every 6 months for patients with cirrhosis, via ultrasonography, with or without measurement of serum level of alpha fetoprotein (AFP).

Methods: We previously developed and internally validated an HCC early detection screening (HES) algorithm that included patient's current level of AFP, rate of AFP change, age, level of alanine aminotransferase, and platelet count in a department of Veterans affairs (VA) cohort with active hepatitis C virus-related cirrhosis. Read More

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December 2018

Moina macrocopa as a non-target aquatic organism for assessment of ecotoxicity of silver nanoparticles: Effect of size.

Chemosphere 2018 Dec 7;219:713-723. Epub 2018 Dec 7.

Food Engineering and Technology Department, Institute of Chemical Technology, Mumbai 400019, Maharashtra, India.

The release of nanomaterials in water reservoirs is hazardous. Very few reports are available on the interaction of different sized nanoparticles with aquatic organisms and aquatic environment. In the present study, silver nanoparticles (AgNPs) having an average particle size of 20. Read More

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December 2018

Ecological improvement assessment of a passive remediation technology for acid mine drainage: Water quality biomonitoring using bivalves.

Chemosphere 2018 Dec 6;219:695-703. Epub 2018 Dec 6.

UNESCO UNITWIN/WiCop Department of Physical-Chemistry, University of Cádiz, Campus Río de San Pedro, 11510, Puerto Real, Cádiz, Spain.

A passive treatment plant, located in the Iberian Pyrite Belt (Huelva, Southwest Spain), was designed for acid mine drainage remediation. Since its installation, the improvement of water quality in terms of hydrochemical composition has been demonstrated successfully. However, according to the Water Framework Directive, the treated effluent must have ecological values for potential living. Read More

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December 2018

Profiling of miRNAs in serum of children with attention-deficit hyperactivity disorder shows significant alterations.

J Psychiatr Res 2018 Dec 8;109:185-192. Epub 2018 Dec 8.

Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; CEINGE-biotecnologie Avanzate, Naples, Italy. Electronic address:

Background: Attention-deficit/hyperactivity disorder (ADHD), a common psychiatric disorder, is identified by abnormal levels of impulsivity, inattention, and hyperactivity. MiRNAs play important roles in neural network development of the brain. Circulating miRNAs (cmiRNAs) are offered as promising noninvasive markers for psychiatric disorders. Read More

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December 2018

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Institute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland. Electronic address:

No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of changes in mRNA, protein, and phosphopeptide expression levels from human temporal cortical samples, with varying degree of AD-related pathology. This approach highlighted fluctuation in synaptic and mitochondrial function as the earliest pathological events in brain samples with AD-related pathology. Read More

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December 2018

Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology.

Neurobiol Dis 2018 Dec 14. Epub 2018 Dec 14.

Melbourne Dementia Research Centre, The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia; Cooperative Research Center for Mental Health, Victoria, Australia. Electronic address:

β-Amyloid pathology is elevated in ~30% of cognitively normal people over 65, and is associated with accelerated neurodegeneration in the pre-clinical stages of Alzheimer's disease. Recent findings reveal that brain iron might also act to propel neurodegeneration in people with underlying amyloid pathology. Here, repeated PET scans of fluorodeoxyglucose (FDG) were used as a biomarker for brain hypometabolism and a downstream biomarker of neurodegeneration to investigate whether levels of ferritin in the cerebrospinal fluid (CSF; a reporter of brain iron load) are associated with prodromal disease progression of people with high β-amyloid pathology determined by established cut-off values in CSF t-tau/Aβ ratio. Read More

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December 2018

Exhaled and nasal nitric oxide measurement in the evaluation of chronic cough.

Nitric Oxide 2018 Dec 14. Epub 2018 Dec 14.

Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli, Naples, Italy.

Chronic cough is one of the most common and troublesome nonspecific respiratory symptom for which patients seek a general practitioner and specialist advice. It is conventionally defined as a cough lasting for more than 8 weeks. Exhaled nitric oxide has proven to be a specific biomarker capable to discriminate between differential diagnoses of chronic cough and simultaneously provide information about the response to specific treatment. Read More

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December 2018

T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028.

J Clin Oncol 2018 Dec 13:JCO2018782276. Epub 2018 Dec 13.

Patrick A. Ott, Dana-Farber Cancer Institute, Boston, MA; Yung-Jue Bang, Seoul National University College of Medicine, Seoul, The Republic of Korea; Sarina A. Piha-Paul, University of Texas MD Anderson Cancer Center, Houston, TX; Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Jaafar Bennouna, Centre Hospitalier Universitaire Nantes, Nantes; Jean-Charles Soria, University Paris-Sud and Gustave Roussy, Villejuif, France; Hope S. Rugo, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Roger B. Cohen, University of Pennsylvania, Philadelphia, PA; Bert H. O'Neil, Indiana University, Bloomington, IN; Janice M. Mehnert, Rutgers Cancer Institute of New Jersey, New Brunswick; Razvan Cristescu, Ping Yang, Kenneth Emancipator, Karen Stein, Mark Ayers, Andrew K. Joe, and Jared K. Lunceford, Merck & Co., Inc., Kenilworth, NJ; Juanita Lopez, Institute of Cancer Research, London, United Kingdom; Toshihiko Doi, National Cancer Center Hospital East, Chiba, Japan; and Emilie M.J. van Brummelen, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Purpose: Biomarkers that can predict response to anti-programmed cell death 1 (PD-1) therapy across multiple tumor types include a T-cell-inflamed gene-expression profile (GEP), programmed death ligand 1 (PD-L1) expression, and tumor mutational burden (TMB). Associations between these biomarkers and the clinical efficacy of pembrolizumab were evaluated in a clinical trial that encompassed 20 cohorts of patients with advanced solid tumors.

Methods: KEYNOTE-028 ( ClinicalTrials. Read More

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December 2018

The biomarker potential of cell-free microRNA from cerebrospinal fluid in Parkinsonian Syndromes.

Mov Disord 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology, Bispebjerg University Hospital, Copenhagen, Denmark.

Background: MicroRNAs are small noncoding RNAs involved in the post-transcriptional regulation of protein synthesis. Extracellular microRNAs are accessible in a stable form in biofluids.

Objectives: The aim was to identify individual microRNAs and/or subsets of microRNAs in CSF with biomarker potential and thus identify specific putative pathophysiological pathways. Read More

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December 2018

Analysing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer.

Proteomics 2018 Dec 17:e1800176. Epub 2018 Dec 17.

UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

Dysbiosis of gut microbiome can contribute to inflammation, and subsequently initiation and progression of colorectal cancer (CRC). Throughout these stages, various proteins and metabolites are secreted to the external environment by microorganisms or the hosts themselves. Studying these proteins may help enhance our understanding of the host-microorganism relationship or they may even serve as useful biomarkers for CRC. Read More

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December 2018

Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer.

PLoS One 2018 17;13(12):e0209104. Epub 2018 Dec 17.

Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Gemcitabine is a principal chemotherapeutic agent for biliary tract cancer (BTC). Expression of human equilibrative nucleoside transporter 1 (hENT1) is regarded as a potential predictive biomarker for a gemcitabine response in some cancers. This study was conducted to investigate the association between hENT1 expression and the effects of gemcitabine on BTC cell lines and on patients with advanced BTC receiving gemcitabine-based chemotherapy. Read More

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December 2018

Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients.

PLoS One 2018 17;13(12):e0208762. Epub 2018 Dec 17.

Department of Epidemiology, Emory University, Atlanta, Georgia, United States of America.

To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of supplemental vitamin D3 (1,000 IU/day [25 μg/day]) and calcium (1,200 mg/day), alone and in combination, on biomarkers of proliferation (mib-1), differentiation (p21), and apoptosis (bax [apoptosis-promoting] and bcl-2 [apoptosis-inhibiting]), in the normal-appearing rectal mucosa in a subsample of participants (n = 104) in a larger randomized, double-blind, placebo-controlled clinical trial among colorectal adenoma patients. The biomarkers were measured in rectal biopsies at baseline and after one year of follow up, using automated immunohistochemistry and quantitative image analysis. In the vitamin D plus calcium group relative to control, in the crypt differentiation zone (upper 40% of crypts), mib-1 expression decreased 24% (P = 0. Read More

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December 2018

miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2.

PLoS Genet 2018 Dec 17;14(12):e1007790. Epub 2018 Dec 17.

Department of Radiation Oncology, North China University of Science and Technology Affiliated People's Hospital, Tangshan, China.

Accumulating evidence indicates that miRNAs can be promising diagnostic and/or prognostic markers for various cancers. In this study, we identified a novel miRNA, miR-3607-3p, and its targets in non-small cell lung cancer (NSCLC). The expression of miR-3607-3p was measured and its correlation with patient prognosis was determined. Read More

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December 2018

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.

PLoS One 2018 17;13(12):e0208998. Epub 2018 Dec 17.

Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Mölndal, Sweden.

Aims/hypothesis: GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets. In rodent islets, PGD2 is produced in response to glucose, suggesting that the PGD2-GPR44/DP2 axis may play a role in human islet function during hyperglycemia. Consequently, the aim of this work was to elucidate the insulinotropic role of GPR44 antagonism in vitro in human beta-cells and in type 2 diabetes (T2DM) patients. Read More

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December 2018

Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis.

PLoS One 2018 17;13(12):e0208905. Epub 2018 Dec 17.

Graduate School, University of Santo Tomas, Manila City, Philippines.

Background: Managing nephropathy associated with diabetes mellitus warrant investigation of relevant biomarkers in predicting this condition. Adiponectin (ADP) may hold promise as a biomarker for diabetic nephropathy (DN). In this study, we examine associations of ADP with DN by meta-analyzing relevant literature. Read More

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December 2018

CSF extracellular vesicles and neurofilament light protein as biomarkers of CNS injury in HIV-infected patients on antiretroviral therapy.

AIDS 2018 Dec 14. Epub 2018 Dec 14.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA.

Objective: The relationship of cerebrospinal fluid (CSF) extracellular vesicles (EVs) to neurocognitive impairment (NCI) in HIV-infected individuals is unclear. Here, we characterize CSF EVs and their association with CNS injury-related biomarkers (neurofilament light [NFL], S100B, neopterin) and NCI in HIV+ subjects on combination antiretroviral therapy (cART).

Design: Cross-sectional and longitudinal study of CSF samples from HIV+ subjects on cART. Read More

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December 2018

Tryptophan metabolism in rheumatoid arthritis is associated with rheumatoid factor and predicts joint pathology evaluated by the Rheumatoid Arthritis MRI Score (RAMRIS).

Clin Exp Rheumatol 2018 Nov 16. Epub 2018 Nov 16.

Department of Rheumatology and Hiller Research Centre for Rheumatology, University Hospital Düsseldorf, Germany.

Objectives: Tryptophan and its metabolites have been suggested to play a role in inflammatory processes. However, studies in rheumatoid arthritis (RA) are scarce, which prompted us to investigate two cohorts of RA patients to better understand the importance of tryptophan metabolism in this disease.

Methods: Tryptophan and its metabolites were characterised by ELISA in a cross-sectional cohort 1 (81 RA, 55 OA) and a longitudinal cohort 2 (25 RA, 3 visits over 6 months) to investigate discriminatory power between diseases and predicitive value for radiologic outcome, respectively. Read More

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November 2018

New insights into the pathophysiology of IgG4-related disease and markers of disease activity.

Expert Rev Clin Immunol 2018 Dec 17. Epub 2018 Dec 17.

a Division of Rheumatology, Department of Internal Medicine , Kanazawa University Graduate School of Medicine , Kanazawa , Japan.

Introduction: Recently, IgG4-related disease (IgG4-RD) has become a well-recognized clinical entity, although its causes are still not well understood. The pathophysiology of IgG4-RD has been reported from a variety of aspects. Areas covered: In this review, we outline a number of recent advances in our understanding of the pathogenesis of IgG4-RD, divided according to acquired immunology and innate immunology and other topics. Read More

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December 2018

Interbreed variation of biomarkers of lipid and glucose metabolism in dogs.

Vet Clin Pathol 2018 Dec 17. Epub 2018 Dec 17.

University of Liège, Liège, Belgium.

Background: Markers of lipid and glucose metabolism are used in both clinical practice and research. Detection of abnormal laboratory results often relies on species-specific reference intervals, but interbreed variation can also affect data interpretation.

Objectives: The purpose of the present study was to compare concentrations of selected biochemical variables among different dog breeds. Read More

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December 2018

Discovery and identification of fatigue-related biomarkers in human saliva.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8519-8536

Hebei University of Engineering, Affiliated Hospital, College of Medicine, Handan, China.

Objective: To identify stable and specific biomarkers/biomarker combinations for fatigue assessment and establish a discriminant model.

Patients And Methods: Saliva was collected and electroencephalogram analysis was performed for 47 emergency physicians while awake and after continuoutas duty for 18-24 h. Physicians were divided into the fatigue and non-fatigue groups. Read More

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December 2018
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Upregulation of long noncoding RNA MRCCAT1 predicts poor prognosis and functions as an oncogene in glioma.

Authors:
J Ma L-J Su Z-J Zheng

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8406-8414

Department of Neurology, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.

Objective: This study aimed to investigate the expressions, clinical significances, roles, and mechanism of action of MRCCAT1 in glioma.

Patients And Methods: The expression of MRCCAT1 in 103 glioma tissues with different grades and 21 normal brain tissues was measured by qPCR. The prognostic value of MRCCAT1 was investigated by Kaplan-Meier survival analysis. Read More

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December 2018

Overexpression of miR-3196 suppresses cell proliferation and induces cell apoptosis through targeting ERBB3 in breast cancer.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8383-8390

Department of General Surgery, Changji Huizu People's Hospital of Xinjiang, Xinjiang, China.

Objective: Breast cancer is one of the most common malignancies worldwide. MicroRNAs (MiRNAs) have been identified to influence cell behaviors through epigenetic post-transcriptional gene regulation. Therefore, the aim of this study was to determine the role of miR-3196 in the proliferation and apoptosis of breast cancer. Read More

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December 2018

Increased expression of miR-1179 inhibits breast cancer cell metastasis by modulating Notch signaling pathway and correlates with favorable prognosis.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8374-8382

Department of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China.

Objective: MicroRNAs (miRNAs) play a key role in the regulation of gene expression. In this study, we aimed to identify the clinical values of miR-1179 and to investigate the potential molecular mechanisms in breast cancer (BC).

Materials And Methods: RT-PCR was used to detect the expression levels of miR-1179 in both BC tissues and cell lines. Read More

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December 2018

Long non-coding RNA LINC00675 inhibits tumorigenesis and EMT via repressing Wnt/β-catenin signaling in esophageal squamous cell carcinoma.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8288-8297

Emergency Department, Shenzhen People's Hospital, the Second Medical College of Jinan University, Shenzhen, Guangdong, China.

Objective: Long noncoding RNA LINC00675 (LINC00675) seems to play an anti-oncogenic role in cancers, though its exact function remains unknown. Up to date, little is known about the role of LINC00675 in esophageal squamous cell carcinoma (ESCC). In this study, we aimed to explore the expression pattern, clinical significance and biological function of LINC00675 in ESCC. Read More

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December 2018

A meta-analysis of the effect of microRNA-34a on the progression and prognosis of gastric cancer.

Authors:
Z Li Z-M Liu B-H Xu

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8281-8287

Department of Interventional Therapy, Harrison International Peace Hospital, Hengshui, Hebei, China.

Objective: To explore the value of microRNA-34a (miR-34a) as a diagnostic biomarker of gastric cancer development and prognosis.

Materials And Methods: PubMed, Web of Science, Embase, CNKI, Wanfang Database and Gene Expression Omnibus (GEO) were searched according to the key words for the literature about the expression of microRNA-34a in the serum or tissues of gastric cancer patients. The data of gene expression were extracted and the data were analyzed by Stata 14. Read More

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December 2018

Circ_0009910 regulates growth and metastasis and is associated with poor prognosis in gastric cancer.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8248-8256

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center for Digestive Diseases, Xi-Cheng District, Beijing, P.R. China.

Objective: Circular RNAs (circRNAs) have recently shown capabilities as gene regulators in mammals. In this study, we aimed to evaluate the effects and mechanism of circ_0009910 in gastric cancer (GC).

Patients And Methods: Circ_0009910 expression was quantified by Real-time PCR in human GC cell lines and tissues. Read More

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December 2018

CircMTO1 inhibits cell proliferation and invasion by regulating Wnt/β-catenin signaling pathway in colorectal cancer.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8203-8209

Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan, China.

Objective: Circular RNAs (circRNAs) play critical roles in disease incidence. However, the roles of circRNAs in colorectal cancer (CRC) progression remain largely unknown. We explored the expression of circMTO1 in CRC and elucidated the underlying molecular mechanisms. Read More

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December 2018

Overexpression of LncRNA FER1L4 in endometrial carcinoma is associated with favorable survival outcome.

Authors:
Y Kong Z Ren

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8113-8118

Department of Oncology, Dalian Third People's Hospital, Dalian, Liaoning, China.

Objective: Long noncoding RNA Fer-1-like protein 4 (FER1L4) is a novel cancer-related lncRNA and functions as a tumor suppressor in several cancers. However, the clinical significance of FER1L4 has not been investigated. The purpose of this study was to investigate whether the increased expression of FER1L4 can be used as a prognostic biomarker in endometrial carcinoma (EC). Read More

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December 2018

Cancer biomarker discovery and translation: proteomics and beyond.

Expert Rev Proteomics 2018 Dec 17. Epub 2018 Dec 17.

a Department of Pathology , Johns Hopkins University School of Medicine , Baltimore , MD 21287.

Introduction: Cancer is often diagnosed at late stages when the chance of cure is relatively low and although research initiatives in oncology discover many potential cancer biomarkers, few transition to clinical applications. This review addresses the current landscape of cancer biomarker discovery and translation with a focus on proteomics and beyond. Areas covered: The review examines proteomic and genomic techniques for cancer biomarker detection and outlines advantages and challenges of integrating multiple omics approaches to achieve optimal sensitivity and address tumor heterogeneity. Read More

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December 2018

Measuring disease activity and response to treatment in rheumatoid arthritis.

Expert Rev Clin Immunol 2018 Dec 17. Epub 2018 Dec 17.

b Department of Musculoskeletal Biology , Institute of Ageing and Chronic Disease, University of Liverpool, Clinical Sciences Centre, Aintree University Hospital , Liverpool.

Introduction: Effective treatment of rheumatoid arthritis (RA) requires suppression of the underlying inflammation. Measurement of such inflammation, the disease activity, is mandatory to target treatment and maximize outcomes. However, this is not as straightforward as it may seem. Read More

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December 2018
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A biomarker and therapeutical target in immune thrombocytopenia: TNF receptor-associated factor 6.

Biomark Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Hematology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Background: Immune thrombocytopenia (ITP) is an acquired disease characterized by various pathogenetic mechanisms. We aimed to evaluate the value of TRAF6 as a biomarker of pathogenesis in ITP.

Methods:  85 newly diagnosed ITP patients and 85 controls were included. Read More

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December 2018

A six-gene assay as a new biomarker in the blood of patients with colorectal cancer: Establishment and clinical validation.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China.

Colorectal cancer (CRC) is the second most common cancer in men and the third most common in women. Although long-term survival has improved over the past 30 years, at least 50% of patients with CRC will develop metastases after diagnosis. In this study, we examined whether quantifying the mRNAs of six CRC-related genes in the blood could improve disease assessment through detection of circulating tumor cells (CTCs), and thereby improve progression prediction in relapsed CRC patients. Read More

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December 2018
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Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.

Background: Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Potential biomarkers to determine prognosis and select targeted therapies are urgently needed for patients with HCC. This study aimed to elucidate the role of UCK2 in HCC prognosis and tumor progression. Read More

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December 2018

Six genes as potential diagnosis and prognosis biomarkers for hepatocellular carcinoma through data mining.

J Cell Physiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Ultrasound, Taizhou Municipal Hospital, Medical College of Taizhou University, Taizhou, 318000, Zhejiang, China.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the third of cancer mortality worldwide. Although the study of HCC has made great progress, the molecular mechanism and signal pathways of HCC are not yet clear. Therefore, it is necessary to investigate the early diagnosis and prognosis biomarkers for HCC. Read More

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December 2018

Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells.

Mol Carcinog 2018 Dec 17. Epub 2018 Dec 17.

Department of Molecular Biology of Cancer, Medical University of Lodz, Poland.

We have extensively studied the phenotypic heterogeneity of patient-derived melanoma cells. Here, whole-exome sequencing revealed novel variants of genes associated with the MAPK, NOTCH, Hippo, cell-cycle, senescence and ubiquitin-dependent pathways, which could contribute to the observed phenotypic diversity between cell lines. Focusing on mutations in MAPK pathway-associated genes, we found BRAF (BRAF ) and RAS subtypes, including NRAS and the rare HRAS variant, and additional alterations potentially leading to different ERK1/2 activity. Read More

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December 2018

A new DNA sensor system for specific and quantitative detection of mycobacteria.

Nanoscale 2018 Dec 17. Epub 2018 Dec 17.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark.

In the current study, we describe a novel DNA sensor system for specific and quantitative detection of mycobacteria, which is the causative agent of tuberculosis. Detection is achieved by using the enzymatic activity of the mycobacterial encoded enzyme topoisomerase IA (TOP1A) as a biomarker. The presented work is the first to describe how the catalytic activities of a member of the type IA family of topoisomerases can be exploited for specific detection of bacteria. Read More

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December 2018

Cellular Senescence and Anti-Cancer Therapy.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058. China.

Background: Cellular senescence is generally understood as permanent cell cycle arrest stemming from different causes. The mechanism of cellular senescence-induced cell cycle arrest is complex, involving interactions between telomere shortening, inflammations and cellular stresses. In recent years, a growing number of studies have revealed that cellular senescence could mediate the cancer progression of neighboring cells, but this idea is controversial and contradictory evidence argues that cellular senescence also contributes to tumor suppression. Read More

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December 2018

Serum and follicular fluid levels of sirtuin 1, sirtuin 6, and resveratrol in women undergoing in vitro fertilization: an observational, clinical study.

J Int Med Res 2018 Dec 16:300060518811228. Epub 2018 Dec 16.

4 Department of Obstetrics and Gynaecology, Medical School, University of Pécs, Pécs, Hungary.

Objective: This observational, clinical study was designed to assess the role of sirtuin 1 (SIRT1), sirtuin 6 (SIRT6), and resveratrol in in vitro fertilization (IVF).

Methods: Paired serum and follicular fluid (FF) samples were obtained from 30 consecutive patients (age: 36.43 ± 4. Read More

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December 2018

Improving the rates of Aspergillus detection: an update on current diagnostic strategies.

Expert Rev Anti Infect Ther 2018 Dec 17:1-12. Epub 2018 Dec 17.

d Division of Infectious Diseases, Department of Medicine , University of California-San Diego , San Diego , CA , USA.

Introduction: The spectrum of disease caused by Aspergillus spp. is dependent on the immune system of the host, and ranges from invasive aspergillosis (IA) to chronic pulmonary aspergillosis (CPA). Early and reliable diagnosis of Aspergillus disease is important to decrease associated morbidity and mortality. Read More

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December 2018

Identification of genes associated with cancer progression and prognosis in lung adenocarcinoma: Analyses based on microarray from Oncomine and The Cancer Genome Atlas databases.

Mol Genet Genomic Med 2018 Dec 16. Epub 2018 Dec 16.

Department of Respiratory and Sleep Medicine in the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Background: Lung adenocarcinoma (LUAD) accounts for approximately 40% of all lung cancer patients. There is an urgent need to understand the mechanisms of cancer progression in LUAD and to identify useful biomarkers to predict prognosis.

Methods: In this study, Oncomine database was used to identify potential genes contributed to cancer progression. Read More

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December 2018
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New molecular diagnostic trends and biomarkers for Amyotrophic Lateral Sclerosis.

Hum Mutat 2018 Dec 17. Epub 2018 Dec 17.

Department of Pharmacy, School of Health Sciences, University of Patras, Rion GR-265 04, Patras, Greece.

Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disorder. Two forms are recognized, familial (FALS) that accounts for 5-10% of ALS cases, and sporadic (SALS) that accounts for the rest. Early diagnosis of ALS is important since it improves their therapeutic efficacy. Read More

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December 2018

Nutrient biomarkers shape individual differences in functional brain connectivity: Evidence from omega-3 PUFAs.

Hum Brain Mapp 2018 Dec 16. Epub 2018 Dec 16.

Decision Neuroscience Laboratory, University of Illinois, Urbana, Illinois.

A wealth of neuroscience evidence demonstrates that diet and nutrition play an important role in structural brain plasticity, promoting the development of gray matter volume and maintenance of white matter integrity across the lifespan. However, the role of nutrition in shaping individual differences in the functional brain connectome remains to be well established. We therefore investigated whether nutrient biomarkers known to have beneficial effects on brain structure (i. Read More

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December 2018

PI3-kinase pathway biomarkers in oral cancer and tumor immune cells.

Head Neck 2018 Dec 16. Epub 2018 Dec 16.

The University of Texas MD Anderson Cancer Center, Department of Thoracic/Head and Neck Medical Oncology.

Background: This study investigated the hypothesis that phosphoinositide 3-kinase (PI3-kinase) pathway dysregulation in either head and neck cancer cells and/or tumor infiltrating immune cells would influence outcomes of patients with surgically treated oral tongue squamous cell carcinomas (SCC).

Methods: We constructed tissue microarrays containing 123 oral tongue SCC samples and performed immunohistochemistry using antibodies against 7 PI3-kinase pathway markers: phosphatase and tensin homolog (PTEN), Akt, p-Akt, mammalian target of rapamycin (mTOR), phosphorylated-mammalian target of rapamycin (p-mTOR), survivin, and Ki-67). Expression levels in cancer cells or tumor infiltrating immune cells were correlated with outcomes. Read More

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December 2018

An 11-gene-based prognostic signature for uveal melanoma metastasis based on gene expression and DNA methylation profile.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Uveal melanoma (UM) is the most common intraocular tumor worldwide. We proposed to identify a vital gene signature that has prognostic value for UM metastasis. For this purpose, we obtained a published DNA methylation and gene expression data set associated with UM from the Gene Expression Omnibus. Read More

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December 2018

Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality.

Int J Cancer 2018 Dec 17. Epub 2018 Dec 17.

Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Although genomic analysis have recently discovered the malignant subtype of human pancreatic ductal adenocarcinoma (PDAC) characterized by frequent mutations of histone demethylase KDM6A, the biological and molecular roles still remain obscure. We herein elucidated the clinical and biological impacts of KDM6A deficiency on human PDAC and identified the therapeutic potential by pathological and molecular evaluation. Immunohistochemical analysis suggested that loss of KDM6A in cancerous tissues was an independent prognostic factor for both recurrence-free and overall survival in the 103 tumor specimens surgically resected from patients with PDAC. Read More

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December 2018
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