327 results match your criteria Biomarker Insights [Journal]


Allostatic Load Indices With Cholesterol and Triglycerides Predict Disease and Mortality Risk in Zoo-Housed Western Lowland Gorillas ().

Biomark Insights 2020 3;15:1177271920914585. Epub 2020 May 3.

Department of Anthropology, The Ohio State University, Columbus, OH, USA.

Allostatic load, or the physiological dysregulation accumulated due to senescence and stress, is an established predictor of human morbidity and mortality and has been proposed as a tool for monitoring health and welfare in captive wildlife. It is estimated by combining biomarkers from multiple somatic systems into allostatic load indices (ALIs), providing a score representing overall physiological dysregulation. Such ALIs have been shown to predict disease and mortality risk in western lowland gorillas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271920914585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218307PMC

Detecting Prostate Cancer Using Pattern Recognition Neural Networks With Flow Cytometry-Based Immunophenotyping in At-Risk Men.

Biomark Insights 2020 17;15:1177271920913320. Epub 2020 Apr 17.

Anixa Biosciences, Inc., San Jose, CA, USA.

Current screening methods for prostate cancer (PCa) result in a large number of false positives making it difficult for clinicians to assess disease status, thus warranting advancements in screening and early detection methods. The goal of this study was to design a liquid biopsy test that uses flow cytometry-based immunophenotyping and artificial neural network (ANN) analysis to detect PCa. Numerous myeloid and lymphoid cell populations, including myeloid-derived suppressor cells, were measured from 156 patients with PCa, 123 with benign prostatic hyperplasia (BPH), and 99 male healthy donor (HD) controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271920913320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169353PMC

Editor-in-Chief Announcement.

Authors:
Jennifer A Byrne

Biomark Insights 2020 9;15:1177271920906676. Epub 2020 Apr 9.

NSW Health Statewide Biobank, Camperdown, NSW, Australia, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

This editorial announces the new Biomarker Insights Editor-in-Chief. The journal will continue to publish high-quality original reports and review articles in all areas of biomarker research, and will welcome submissions that focus on improving the quality of the biomarker research literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271920906676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153173PMC

Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo.

Biomark Insights 2020 31;15:1177271920903038. Epub 2020 Jan 31.

Scientific Research Center, Medical Services Department for Armed Forces, Riyadh, Saudi Arabia.

The is associated with susceptibility to autoimmune diseases. The functional polymorphism in at 1857 is a strong risk factor for vitiligo susceptibility in Europeans; however, controversy exits in other populations. Present study was aimed to determine whether the PTPN22 C1857T polymorphism confers susceptibility to vitiligo in Saudi Arabians. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271920903038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003175PMC
January 2020

Blood Biomarkers of Parenchymal Damage in Ischemic Stroke Patients Treated With Revascularization Therapies.

Biomark Insights 2019 24;14:1177271919888225. Epub 2019 Dec 24.

Stroke Unit, Careggi University Hospital, Florence, Italy.

Purpose: Postischemic reperfusion injury may exacerbate cerebral damage and capillary dysfunction, leading to brain edema (BE), hemorrhagic transformation (HT), necrosis, and injury from free radicals with subsequent infarct growth (IG). Several plasmatic biomarkers involved in the ischemic cascade have been studied in relation to radiological and clinical outcomes of reperfusion injury in ischemic stroke with heterogeneous results. This article provides a brief overview of the contribution of circulating biomarkers to the pathophysiology of parenchymal damage in ischemic stroke patients treated with revascularization therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919888225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931146PMC
December 2019

Fc Receptor-Like 1 as a Promising Target for Immunotherapeutic Interventions of B-Cell-Related Disorders.

Biomark Insights 2019 19;14:1177271919882351. Epub 2019 Nov 19.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Human B-cell responses are regulated through synergy between a collection of activation and inhibitory receptors. Fc receptor-like (FCRL) molecules have recently been identified as co-receptors that are preferentially expressed in human B-cells, which may also play an important role in the regulation of human B-cell responses. FCRL1 is a member of the FCRL family molecules with 2 immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic tail. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919882351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864034PMC
November 2019

Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls: A Case-Control Study at Korle-Bu Teaching Hospital, Accra.

Biomark Insights 2019 5;14:1177271919873889. Epub 2019 Sep 5.

Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.

The activity of Na-K ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919873889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728659PMC
September 2019
5 Reads

Serum Metabolomic Profiles of Rheumatoid Arthritis Patients With Acute-Onset Diffuse Interstitial Lung Disease.

Biomark Insights 2019 22;14:1177271919870472. Epub 2019 Aug 22.

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.

Objective: Acute-onset diffuse interstitial lung disease (AoDILD) includes acute exacerbation of interstitial lung disease (ILD), drug-induced ILD, and pneumonia, and frequently occurs in patients with rheumatoid arthritis (RA). Since AoDILD causes a poor prognosis in RA, biomarkers for AoDILD were eagerly desired. Metabolomic analyses were extensively performed in cancer patients and successfully generated better diagnostic biomarkers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919870472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709435PMC
August 2019
1 Read

Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density.

Biomark Insights 2019 19;14:1177271919843825. Epub 2019 Aug 19.

Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait.

Introduction: Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial. The aim of this study was to measure circulatory levels of these parameters in postmenopausal women with normal or low BMD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919843825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700864PMC
August 2019
1 Read

A Comparison of Death Domain-Associated Protein 6 in Different Endometrial Carcinomas Histotypes.

Biomark Insights 2019 23;14:1177271919864892. Epub 2019 Jul 23.

Department of Pathology, Northwell Health Systems, New Hyde Park, NY, USA.

Background: Death domain-associated protein 6 (DAXX) is involved in regulating apoptosis via subcellular localization. The presence of DAXX point mutations correlates well with loss of nuclear expression on immunohistochemistry (IHC). In this study, we sought to determine (1) whether DAXX expression pattern is the same across different uterine carcinoma subtypes, and (2) which uterine carcinomas show loss of nuclear DAXX IHC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919864892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651668PMC
July 2019
1 Read

Cerebral Expression of Glial Fibrillary Acidic Protein, Ubiquitin Carboxy-Terminal Hydrolase-L1, and Matrix Metalloproteinase 9 After Traumatic Brain Injury and Secondary Brain Insults in Rats.

Biomark Insights 2019 4;14:1177271919851515. Epub 2019 Jun 4.

Department of Anesthesiology and Critical Care, University Hospital of Toulouse, Toulouse, France.

Glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), and matrix metalloproteinase 9 (MMP-9) are potential biomarkers of traumatic brain injury (TBI) but also of secondary insults to the brain. The aim of this study was to describe the cerebral distribution of GFAP, UCH-L1, and MMP-9 in a rat model of diffuse TBI associated with standardized hypoxia-hypotension (HH). Adult male Sprague-Dawley rats were allocated to Sham (n = 10), TBI (n = 10), HH (n = 10), and TBI+HH (n = 10) groups. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1177271919851515
Publisher Site
http://dx.doi.org/10.1177/1177271919851515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552356PMC
June 2019
12 Reads

Neutrophil to Lymphocyte Ratio is a Predictive Factor of Malignant Potential for Intraductal Papillary Mucinous Neoplasms of the pancreas.

Biomark Insights 2019 4;14:1177271919851505. Epub 2019 Jun 4.

Department of Gastroenterological Surgery, Ehime Prefectural Central Hospital, Matsuyama-city, Ehime, Japan.

Intraductal papillary mucinous neoplasms (IPMNs) are cystic neoplasms with the potential for progression to pancreatic cancer. Accurate prediction of the malignant potential is challenging and a proper treatment strategy has not been well established. Preoperative neutrophil-to-lymphocyte ratio (NLR) is a biomarker of the malignant potential in patients with several types of malignancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919851505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552332PMC
June 2019
15 Reads

Prognostic Value of MMP-9 -1562 C/T Gene Polymorphism in Patients With Sepsis.

Biomark Insights 2019 20;14:1177271919847951. Epub 2019 May 20.

Department of Medicine, Faculty of Health Sciences, Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.

Introduction: Matrix metalloproteinase-9 (MMP-9) plays an important role in the pathophysiology of sepsis. A single-nucleotide polymorphism (SNP) at position -1562 (C/T) in the MMP-9 gene has been associated with differential MMP-9 expression, being higher when the -1562 T allele is present. We evaluated the association of the SNP MMP9 -1562 C/T with severity and mortality in patients with sepsis to establish whether the prognosis of the disease is affected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919847951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535903PMC
May 2019
8 Reads

Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and DNMT3B in Acute Myeloid Leukaemia.

Biomark Insights 2019 8;14:1177271919846454. Epub 2019 May 8.

Department of Pathology, Odense University Hospital, Odense, Denmark.

Epigenetic alteration has been proposed to give rise to numerous classic hallmarks of cancer. Impaired DNA methylation plays a central role in the onset and progression of several types of malignancies, and DNA methylation is mediated by DNA methyltransferases (DNMTs) consisting of DNMT1, DNMT3A, and DNMT3B. DNMTs are frequently implicated in the pathogenesis and aggressiveness of acute myeloid leukaemia (AML) patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919846454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509988PMC
May 2019
17 Reads

Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy.

Biomark Insights 2019 17;14:1177271919842180. Epub 2019 Apr 17.

Centre for Dermatology Research, University of Manchester, Manchester, UK.

Damage to hair follicles following exposure to toxic chemotherapeutics can cause substantial hair loss, commonly known as chemotherapy-induced alopecia (CIA). Preventive therapies remain limited; however, recent advances in the use of scalp cooling technologies have proved successful in preventing or reducing hair loss in some patients. Further improvements in scalp cooling efficacy and/or development of novel treatments to prevent chemotherapy-induced hair loss are required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919842180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475836PMC
April 2019
16 Reads

Identification of Urinary CD44 and Prosaposin as Specific Biomarkers of Urinary Tract Infections in Children With Neurogenic Bladders.

Biomark Insights 2019 15;14:1177271919835570. Epub 2019 Mar 15.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Purpose: Distinguishing urinary tract infection (UTI) from urinary tract colonization (UTC) in children with neurogenic bladders who require clean intermittent catheterization (CIC) is challenging. Our objective was to identify urinary proteins to distinguish UTI from UTC in CIC-dependent children that have potential to serve as objective markers of UTI.

Experimental Design: A total of 10 CIC-dependent children were included in the mass spectrometry analysis (UTI = 5, UTC = 5). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919835570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421595PMC
March 2019
2 Reads

C677T Gene Polymorphism as Risk Factor for Psoriasis in Saudis.

Biomark Insights 2019 24;14:1177271919830973. Epub 2019 Feb 24.

Scientific Research Center, Medical Services Department of Armed Forces, Riyadh, Saudi Arabia.

has been linked with the etiopathogenesis of psoriasis with inconsistent results. C677T polymorphism was evaluated in 106 Saudi psoriasis vulgaris patients and 280 matched healthy controls using PCR-RFLP (restriction fragment length plymorphism) technique. The cardiovascular risk factors were also compared in cases and controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919830973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390219PMC
February 2019
17 Reads

The Possibility of Systematic Research Fraud Targeting Under-Studied Human Genes: Causes, Consequences, and Potential Solutions.

Biomark Insights 2019 5;14:1177271919829162. Epub 2019 Feb 5.

Univ Grenoble Alpes, CNRS, Grenoble INP, LIG, Grenoble, France.

A major reason for biomarker failure is the selection of candidate biomarkers based on inaccurate or incorrect published results. Incorrect research results leading to the selection of unproductive biomarker candidates are largely considered to stem from unintentional research errors. The additional possibility that biomarker research may be actively misdirected by research fraud has been given comparatively little consideration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919829162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366001PMC
February 2019
21 Reads

Technical and Regulatory Considerations for Taking Liquid Biopsy to the Clinic: Validation of the JAX PlasmaMonitor Assay.

Biomark Insights 2019 1;14:1177271919826545. Epub 2019 Feb 1.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

The standard of care in oncology has been genomic profiling of tumor tissue biopsies for the treatment and management of disease, which can prove to be quite challenging in terms of cost, invasiveness of procedure, and potential risk for the patient. As the number of available drugs in oncology continues to increase, so too does the demand for technologies and testing applications that can identify genomic alterations targetable by these new therapies. Liquid biopsies that use a blood draw from the diseased patient may offset the many disadvantages of the invasive procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919826545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360476PMC
February 2019
24 Reads

The Fraction Exhaled Nitric Oxide as a Biomarker of Asthma Control.

Biomark Insights 2019 31;14:1177271919826550. Epub 2019 Jan 31.

Faculty of Medicine, Universidade Federal de Goias (UFG), Goiânia, Brazil.

Introduction And Objective: The main goal of asthma treatment is to achieve and maintain clinical control of the disease. The exhaled fraction nitric oxide (FeNO) level is a biomarker of T-helper cell type 2 (Th2) inflammation of the airways. Our objective was to determine whether the FeNO level can be used to discriminate between patients with controlled, partially controlled, and uncontrolled asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271919826550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357290PMC
January 2019
20 Reads

Peripheral Biomarker for Vascular Disorders.

Biomark Insights 2018 29;13:1177271918812467. Epub 2018 Nov 29.

School of Life Sciences and Centre for Health Technologies, University of Technology Sydney, Broadway, NSW, Australia.

Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischaemic stroke episodes. An early sign of atherosclerosis is hypertrophy of the arterial wall. It is known that increased intima media thickness (IMT) is a non-invasive marker of arterial wall alteration, which can easily be assessed in the carotid arteries by high-resolution B-mode ultrasound. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918812467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287300PMC
November 2018
37 Reads

Integration of Biomarkers Into a Signature Profile of Persistent Traumatic Brain Injury Involving Autoimmune Processes Following Water Hammer Injury From Repetitive Head Impacts.

Biomark Insights 2018 29;13:1177271918808216. Epub 2018 Oct 29.

Department of Psychology, The University of Texas at Austin and Austin Radiological Association, Austin, TX, USA.

Objectives: To assemble an algorithm that will describe a "Signature" predictive of an individual's vulnerability to persistent traumatic brain injury (TBI).

Subjects And Methods: Studies of athletes and warriors who are subjected to repeated head impacts with rapid acceleration/deceleration forces are used to assist in the diagnosis and management of TBI-affected individuals. Data from multiple areas, including clinical, anatomical, magnetic resonance imaging, cognitive function, and biochemical analyses, are integrated to provide a Signature of persistent TBI. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1177271918808216
Publisher Site
http://dx.doi.org/10.1177/1177271918808216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207974PMC
October 2018
38 Reads

MicroRNAs as Biomarkers of B-cell Lymphoma.

Biomark Insights 2018 16;13:1177271918806840. Epub 2018 Oct 16.

Molecular Oncology Group, Biodonostia Research Institute, San Sebastián, Spain.

B-cell lymphomas represent a diverse group of neoplasms classified primarily by histopatholgy and are often challenging to accurately diagnose. Despite having been recognized less than 20 years ago, microRNAs (miRNAs) have emerged as one of the most promising class of cancer molecular biomarkers and are particularly attractive as they can be readily detected in formalin-fixed paraffin-embedded biopsy material and biological fluids such as blood. Many of the identified B-cell lymphoma miRNA biomarkers also play crucial regulatory roles in normal B-cell development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918806840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195009PMC
October 2018
28 Reads

Identifying Reliable Diagnostic/Predictive Biomarkers for Rheumatoid Arthritis.

Biomark Insights 2018 24;13:1177271918801005. Epub 2018 Sep 24.

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK.

Introduction And Objective: Elevated C-reactive protein is usually a good indicator of rheumatoid arthritis (RA); however, there are limitations that compromise its specificity and therefore there is an urgent need to identify more reliable diagnostic biomarkers to detect early stages of RA. In addition, identifying the correct therapeutic biomarker for the treatment of RA using methotrexate (MTX) would greatly increase the benefits experienced by the patients.

Materials And Methods: Primary normal synoviocytes human fibroblast-like synoviocytes (HFLS) and its phenotype rheumatic HFLS-RA cells were chosen for this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918801005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153528PMC
September 2018
10 Reads

Cytokine Measurements for Diagnosing and Characterizing Leukemoid Reactions and Immunohistochemical Validation of a Granulocyte Colony-Stimulating Factor and CXCL8-Producing Renal Cell Carcinoma.

Biomark Insights 2018 17;13:1177271918792246. Epub 2018 Aug 17.

Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: Various paraneoplastic syndromes are encountered in renal cell carcinomas. This case report illustrates that a paraneoplastic leukemoid reaction may precede the diagnosis of renal cell carcinoma and be explained by cytokine production from the cancer cells.

Case Presentations: A 64-year-old man was referred for hematology workup due to pronounced leukocytosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918792246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100120PMC
August 2018
4 Reads

Is Procalcitonin Useful in Pediatric Critical Care Patients?

Biomark Insights 2018 7;13:1177271918792244. Epub 2018 Aug 7.

Pediatric Intensive Care Unit, Paediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, CIBERESP, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.

This review examines the use of procalcitonin in different clinical situations in the pediatric patient, with special emphasis on those requiring intensive care. We review the latest articles on its potency as a biomarker in both infectious processes at diagnosis and on the response to treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918792244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081751PMC
August 2018
9 Reads

Development of a Novel Proteomic Risk-Classifier for Prognostication of Patients With Early-Stage Hormone Receptor-Positive Breast Cancer.

Biomark Insights 2018 30;13:1177271918789100. Epub 2018 Jul 30.

OncoStem Diagnostics, Bangalore, India.

Use of proteomic strategies to identify a risk classifier that estimates probability of distant recurrence in early-stage hormone receptor (HR)-positive breast cancer is relevant to physiological cellular function and therefore to intrinsic tumor biology. We used a 298-sample retrospective training set to develop an immunohistochemistry-based novel risk classifier called CanAssist-Breast (CAB) which combines 5 prognostically relevant biomarkers and 3 clinico-pathological parameters to arrive at probability of distant recurrence within 5 years from diagnosis. Five selected biomarkers, namely, CD44, ABCC4, ABCC11, N-cadherin, and pan-cadherin, were chosen based on their role in tumor metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918789100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066801PMC
July 2018
19 Reads

Heart Rate Variability as a Biomarker for Predicting Stroke, Post-stroke Complications and Functionality.

Biomark Insights 2018 18;13:1177271918786931. Epub 2018 Jul 18.

Neuroscience Research Unit, School of Life Sciences, University of Technology Sydney, Broadway, NSW, Australia.

Background: Heart rate variability (HRV) is a non-invasive measure of the function of the autonomic nervous system, and its dynamic nature may provide a means through which stroke and its associated complications may be predicted, monitored, and managed.

Objective: The objective of this review is to identify and provide a critique on the most recent uses of HRV in stroke diagnosis/management and highlight areas that warrant further research.

Methods: The MEDLINE, CINAHL, and OVID MEDLINE databases were canvassed using a systematic search strategy, for articles investigating the use of HRV in stroke diagnosis and management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918786931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052496PMC
July 2018
25 Reads

Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases.

Biomark Insights 2018 5;13:1177271918785130. Epub 2018 Jul 5.

School of Life Sciences, University of Technology Sydney, Broadway, NSW, Australia.

Cardiovascular disease (CVD) is the leading cause of death in the world and our approach to the control and management of CVD mortality is limited. Nattokinase (NK), the most active ingredient of natto, possesses a variety of favourable cardiovascular effects and the consumption of Natto has been linked to a reduction in CVD mortality. Recent research has demonstrated that NK has potent fibrinolytic activity, antihypertensive, anti-atherosclerotic, and lipid-lowering, antiplatelet, and neuroprotective effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918785130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043915PMC
July 2018
54 Reads

Multiple Endocrine Neoplasia Syndromes from Genetic and Epigenetic Perspectives.

Biomark Insights 2018 2;13:1177271918785129. Epub 2018 Jul 2.

Chronic Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Multiple endocrine neoplasia (MEN) syndromes are infrequent inherited disorders in which more than one endocrine glands develop noncancerous (benign) or cancerous (malignant) tumors or grow excessively without forming tumors. There are 3 famous and well-known forms of MEN syndromes (MEN 1, MEN 2A, and MEN 2B) and a newly documented one (MEN4). These syndromes are infrequent and occurred in all ages and both men and women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918785129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043927PMC
July 2018
24 Reads

High Frequency of Extractable Nuclear Autoantibodies in Wheat-Related Disorders.

Biomark Insights 2018 18;13:1177271918782893. Epub 2018 Jun 18.

Vibrant Sciences LLC, San Carlos, CA, USA.

Background And Aims: There has been broad interest to explore the presence of autoimmunity among wheat-sensitive individuals, but neither the pathogenesis nor the relevance has been established. In this study, we evaluated the frequencies and levels of autoantibodies, which are important biomarkers of autoimmunity, in subjects with wheat-related disorders and controls. Anti-nuclear antibodies (ANA) and the specific ones against extractable nuclear antigens (ENA) were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918782893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024268PMC
June 2018
58 Reads

Cytokine Gene Polymorphisms in Saudi Patients With Atopic Dermatitis: A Case-Control Study.

Biomark Insights 2018 4;13:1177271918777760. Epub 2018 Jun 4.

Scientific Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

The cause of atopic dermatitis (AD) is multifactorial and a number of genes including cytokines have been involved. We genotyped 315 subjects for polymorphisms in and and genes. Patients had significantly higher frequency of GA genotype of TNF-α (-308 G/A) than healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918777760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989047PMC
June 2018
10 Reads

Impaired Cerebral Perfusion in Multiple Sclerosis: Relevance of Endothelial Factors.

Biomark Insights 2018 18;13:1177271918774800. Epub 2018 May 18.

Unit of Neurology and Clinical Neurophysiology, Department of Neurological and Neurosensory Sciences, University Hospital of Siena, Siena, Italy.

Magnetic resonance imaging techniques measuring in vivo brain perfusion and integrity of the blood-brain barrier have developed rapidly in the past decade, resulting in a wide range of available methods. This review first discusses their principles, possible pitfalls, and potential for quantification and outlines clinical application in neurological disorders. Then, we focus on the endothelial cells of the blood-brain barrier, pointing out their contribution in regulating vascular tone by production of vasoactive substances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918774800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960845PMC
May 2018
5 Reads

The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study.

Biomark Insights 2018 3;13:1177271918771969. Epub 2018 May 3.

Division of Cardiovascular Medicine, Department of Medicine, University at Buffalo, Buffalo, NY, USA.

Introduction: Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking galectin-3 expression would have an impact on the heart and that its relationship to remodeling is not simply an epiphenomenon. The direct association between galectin-3 and myocardial inflammation, dysfunction, and adverse cardiovascular outcomes post-MI was examined using clinical and translational studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918771969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946633PMC
May 2018
33 Reads

Lipidomic Profiling of Plasma and Erythrocytes From Septic Patients Reveals Potential Biomarker Candidates.

Biomark Insights 2018 26;13:1177271918765137. Epub 2018 Mar 26.

Laboratory of Multidisciplinary Research, Sao Francisco University, USF, Sao Francisco de Assis Avenue, Brazil.

Background: Sepsis remains the primary cause of death from infection, despite advances in modern medicine. The identification of reliable diagnostic biomarkers for the early detection of this disease is critical and may reduce the mortality rate as it could allow early treatment. The purpose of this study was to describe the changes in the plasma and red cells blood lipidome profiling of patients diagnosed with sepsis and septic shock with the aim to identify potentially useful metabolic markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918765137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882049PMC
March 2018
15 Reads

Technical Validation of a Reverse-Transcription Quantitative Polymerase Chain Reaction In Vitro Diagnostic Test for the Determination of MiR-31-3p Expression Levels in Formalin-Fixed Paraffin-Embedded Metastatic Colorectal Cancer Tumor Specimens.

Biomark Insights 2018 16;13:1177271918763357. Epub 2018 Mar 16.

IntegraGen SA, Evry, France.

MiR-31-3p expression has been shown to be a predictive biomarker for response to anti-epithelial growth factor receptor therapy in patients with RAS wild-type metastatic colorectal cancer (mCRC). To aid in the quantification of miR-31-3p expression in formalin-fixed paraffin-embedded (FFPE) primary tumor samples from patients with mCRC, a reverse-transcription quantitative polymerase chain reaction (RT-qPCR) assay was developed and validated. Assay development included the identification of a microRNA reference standard and the determination of an appropriate relative quantification cutoff for differentiating low versus high miR-31-3p expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918763357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858679PMC
March 2018
17 Reads

A Homogeneous Time-Resolved Fluorescence Immunoassay Method for the Measurement of Compound W.

Biomark Insights 2018 6;13:1177271918757484. Epub 2018 Feb 6.

Division of Nuclear Medicine and Medical Services, Department of Radiological Sciences, School of Medicine, UC Irvine Medical Center and VA Long Beach Healthcare System, Long Beach, CA, USA.

Objective: Using compound W (a 3,3'-diiodothyronine sulfate [TS] immuno-crossreactive material)-specific polyclonal antibodies and homogeneous time-resolved fluorescence immunoassay assay techniques (AlphaLISA) to establish an indirect competitive compound W (ICW) quantitative detection method.

Method: Photosensitive particles (donor beads) coated with compound W or TS and rabbit anti-W antibody were incubated with biotinylated goat anti-rabbit antibody. This constitutes a detection system with streptavidin-coated acceptor particle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918757484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808953PMC
February 2018
9 Reads

Nkx2-3-A Slippery Slope From Development Through Inflammation Toward Hematopoietic Malignancies.

Biomark Insights 2018 6;13:1177271918757480. Epub 2018 Feb 6.

Department of Immunology and Biotechnology, Medical School, University of Pécs, Pécs, Hungary.

The development of peripheral lymphoid tissues from the mesoderm is the result of a complex convergence combining lymphohematopoietic differentiation with the local specification of nonhematopoietic mesenchymal components. Although the various transcriptional regulators with fate-determining effects in diversifying the mobile leukocyte subsets have been thoroughly studied and identified, the tissue-specific determinants promoting the regional differentiation of resident mesenchyme are less understood. Of these factors, various members of the NK-class Nkx paralogues have emerged as key regulators for the organogenesis of spleen and mucosal lymphoid tissues, and recent data have also indicated their involvement in various pathological events, including gut inflammation and hematopoietic malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918757480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808962PMC
February 2018
9 Reads

Prion Proteins Without the Glycophosphatidylinositol Anchor: Potential Biomarkers in Neurodegenerative Diseases.

Biomark Insights 2018 6;13:1177271918756648. Epub 2018 Feb 6.

Department for the Production of Diagnostic Reagents and Research, Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia.

Prion protein (PrP) is a biomolecule that is involved in neuronal signaling, myelinization, and the development of neurodegenerative diseases. In the cell, PrP is shed by the ADAM10 protease. This process generates PrP molecules that lack glycophosphatidylinositol anchor, and these molecules incorporate into toxic aggregates and neutralize toxic oligomers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918756648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808966PMC
February 2018
10 Reads

Reactive Oxygen Species: A Key Constituent in Cancer Survival.

Biomark Insights 2018 6;13:1177271918755391. Epub 2018 Feb 6.

Cancer Biology Lab, Department of Biochemistry, GIS, GITAM (Deemed to be University), Visakhapatnam, India.

Background: Cancer is one of the major heterogeneous disease with high morbidity and mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in redox balance, and deregulated redox signaling are common hallmarks of cancer progression and resistance to treatment. Mitochondria contribute mainly in the generation of ROS during oxidative phosphorylation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271918755391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808965PMC
February 2018
195 Reads

Evaluation of a Serum Lung Cancer Biomarker Panel.

Biomark Insights 2018 15;13:1177271917751608. Epub 2018 Jan 15.

20/20 GeneSystems, Rockville, MD, USA.

Background: A panel of 3 serum proteins and 1 autoantibody has been developed to assist with the detection of lung cancer. We aimed to validate the accuracy of the biomarker panel in an independent test set and explore the impact of adding a fourth serum protein to the panel, as well as the impact of combining molecular and clinical variables.

Methods: The training set of serum samples was purchased from commercially available biorepositories. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1177271917751608
Publisher Site
http://dx.doi.org/10.1177/1177271917751608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772503PMC
January 2018
18 Reads

Kinetics of Procalcitonin in Pediatric Patients on Extracorporeal Membrane Oxygenation.

Biomark Insights 2018 8;13:1177271917751900. Epub 2018 Jan 8.

Pediatric Intensive Care Unit, Paediatric Infectious Diseases Research Group, Institut Recerca Hospital Sant Joan de Déu, Hospital Sant Joan de Déu, CIBERESP, Barcelona, Spain.

Objectives: To assess the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) in pediatric patients who required extracorporeal membrane oxygenation (ECMO) and to analyze its relationship with morbidity and mortality.

Patients And Methods: Prospective observational study including pediatric patients who required ECMO. Both PCT and CRP were sequentially drawn before ECMO (P0) and until 72 hours after ECMO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917751900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764148PMC
January 2018
39 Reads

Discovery and Longitudinal Evaluation of Candidate Biomarkers for Ischaemic Stroke by Mass Spectrometry-Based Proteomics.

Biomark Insights 2017 20;12:1177271917749216. Epub 2017 Dec 20.

Stroke Department, The Florey Institute of Neuroscience & Mental Health and Melbourne Brain Centre, Melbourne, VIC, Australia.

Application of acute therapies such as thrombolysis for ischaemic stroke (IS) is constrained because of diagnostic uncertainty and the dynamic nature of stroke biology. To investigate changes in blood proteins after stroke and as a result of thrombolysis treatment we performed label-free quantitative proteomics on serum samples using high-resolution mass spectrometry and long high-performance liquid chromatography gradient (5 hours) combined with a 50-cm column to optimise the peptide separation. We identified (false discovery rate [FDR]: 1%) and quantified a total of 574 protein groups from a total of 92 samples from 30 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917749216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751906PMC
December 2017
22 Reads

Plasma Cytochrome c Detection Using a Highly Sensitive Electrochemiluminescence Enzyme-Linked Immunosorbent Assay.

Biomark Insights 2017 13;12:1177271917746972. Epub 2017 Dec 13.

Resuscitation Institute, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

Background: Cytochrome c is an intermembrane mitochondrial protein that is released to the bloodstream following mitochondrial injury.

Methods And Results: We developed an electrochemiluminescence immunoassay to measure cytochrome c in human and rat plasma, which showed high sensitivity with broad dynamic range (2-1200 ng/mL in humans and 5-500 ng/mL in rat) and high assay reproducibility (inter-assay coefficient <6% in humans and <10% in rat). In patients after blunt trauma, plasma cytochrome c directly correlated with injury severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917746972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731609PMC
December 2017
19 Reads

Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation.

Biomark Insights 2017 7;12:1177271917730306. Epub 2017 Sep 7.

Immunology, Janssen Research & Development, LLC, Spring House, PA, USA.

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and development of novel therapeutics requires an understanding of pathophysiologic phenotypes.

Objectives: The purpose of the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study was to correlate clinical features and biomarkers with molecular characteristics in a well-profiled COPD cohort.

Methods: A total of 67 COPD subjects (forced expiratory volume in the first second of expiration [FEV]: 45%-80% predicted) and 63 healthy smoking and nonsmoking controls underwent multiple assessments including patient questionnaires, lung function, and clinical biomarkers including fractional exhaled nitric oxide (FENO), induced sputum, and blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917730306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593220PMC
September 2017
25 Reads

Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6.

Biomark Insights 2017 12;12:1177271917730557. Epub 2017 Sep 12.

University of Kentucky, Lexington, KY, USA.

Objective: The aim of the study was to define pharmacodynamic markers for sudemycin D6, an experimental cancer drug that changes alternative splicing in human blood.

Methods: Blood samples from 12 donors were incubated with sudemycin D6 for up to 24 hours, and at several time points total RNA from lymphocytes was prepared and the pre-messenger RNA (mRNA) splicing patterns were analyzed with reverse transcription-polymerase chain reaction.

Results: Similar to immortalized cells, blood lymphocytes change alternative splicing due to sudemycin D6 treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917730557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598794PMC
September 2017
113 Reads

Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?

Biomark Insights 2017 24;12:1177271917726964. Epub 2017 Aug 24.

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.

Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. 3T3-L1 embryonic fibroblasts were cultured and differentiated into adipocytes using an established protocol. Adipocytes were treated with lipopolysaccharide (LPS) to induce inflammation and thus MCP-1 release. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1177271917726964
Publisher Site
http://dx.doi.org/10.1177/1177271917726964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574472PMC
August 2017
13 Reads

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells.

Biomark Insights 2017 22;12:1177271917715443. Epub 2017 Jun 22.

Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands.

The urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for various malignancies. The aim of this study is to assess the prognostic value of uPAR expression in neoplastic and stromal cells of patients with pancreatic adenocarcinoma. Urokinase plasminogen activator receptor expression was determined by immunohistochemistry in 122 pancreatic ductal adenocarcinomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917715443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484551PMC
June 2017
29 Reads

Making Meaningful Clinical Use of Biomarkers.

Biomark Insights 2017 19;12:1177271917715236. Epub 2017 Jun 19.

Division of Biochemistry, Department of Basic Sciences and Center for Health Disparities & Molecular Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.

This review discusses the current state of biomarker discovery for the purposes of diagnostics and therapeutic monitoring. We underscore relevant challenges that have defined the gap between biomarker discovery and meaningful clinical use. We highlight recent advancements in and propose a way to think about future biomarker development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917715236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479428PMC
June 2017
40 Reads

Influence of Circulating Endothelin-1 and Asymmetric Dimethylarginine on Whole Brain Circulation Time in Multiple Sclerosis.

Biomark Insights 2017 6;12:1177271917712514. Epub 2017 Jun 6.

Unit of Neurology and Neurophysiology, Department of Neurological and Neurosensorial Sciences, University of Siena, Siena, Italy.

Blood-brain barrier (BBB) breakdown, inflammatory and immune cell activation, and chronic cerebral hypoperfusion are features of multiple sclerosis (MS). The aim is to determine the influence of endothelin-1 (ET1) and asymmetric dimethylarginine (ADMA) on cerebral circulation time (CCT) in patients with MS. In all, 64 patients with MS (39 relapsing-remitting [RR]-MS; 25 secondary progressive [SP]-MS subtype) and 37 controls (C) were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177271917712514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462479PMC
June 2017
33 Reads