7,740 results match your criteria Biomacromolecules [Journal]


Correlation between drug loading content and biological activity: the complexity demonstrated in paclitaxel-loaded glycopolymer micelle system.

Biomacromolecules 2019 Feb 15. Epub 2019 Feb 15.

Drug delivery carriers are now widely established as they can increase the therapeutic efficiency of drugs. In general, the aim in this field is to create effective carriers that have large amounts of drugs loaded in order to minimize drug carrier material that needs to be disposed of. However, there was little attention so far in the literature on the effect of the amount of loaded drugs on the biological activity. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01707DOI Listing
February 2019

A study of the physical and mechanical properties of aerogels obtained from bacterial cellulose.

Biomacromolecules 2019 Feb 15. Epub 2019 Feb 15.

Aerogels with a density of 4.2-22.8 kg/m3 were obtained from bacterial cellulose synthesized in static and dynamic cultivation conditions on a molasses medium. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01816DOI Listing
February 2019

An osteoclast-responsive, injectable bone of bisphosphonated-nanocellulose that regulates osteoclast/osteoblast activity for bone regeneration.

Biomacromolecules 2019 Feb 15. Epub 2019 Feb 15.

An injectable bone may serve as a minimally invasive therapy for large orthopedic defects and osteoporosis and an alternative to allografting and surgical treatment. However, conventional bone substitutes lack the desirable biodegradability, bioresponsibility, and functionality to regulate the bone regeneration process. Here, we report an injectable, bioresponsive bone composed of bisphosphonate-modified nanocellulose (pNC) as a bone substitute for bone regeneration. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01767DOI Listing
February 2019

Self-assembling Non-conjugated Poly(amide-imide) into Thermoresponsive Nanovesicles with Unexpected Red fluorescence for Bioimaging.

Biomacromolecules 2019 Feb 14. Epub 2019 Feb 14.

Non-conjugated red fluorescent polymers have been increasingly studied to improve the biocompatibility and penetration depth over conventional fluorescent materials. However, the accessibility of such polymers remains challenging due to the scarcity of non-conjugated fluorophores and lacking relevant mechanism of red-shifted fluorescence. Herein, we discovered that the combination of hydrogen bonding and π-π stacking interactions provides non-conjugated poly(amide-imide) with a large bathochromic shift (> 100 nm) from blue-green fluorescence to red emission. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00051DOI Listing
February 2019

Divergent Supramolecular Gelation of Backbone Modified Short Hybrid δ-Peptides.

Biomacromolecules 2019 Feb 12. Epub 2019 Feb 12.

The ordered supramolecular assemblies of short peptides have been recently gaining momentum due to their wide spread applications in biology and materials sciences. In contrast to the α-peptides, limited success has been achieved from the backbone modified peptides. The proteolytic stability and conformational flexibility of the backbone modified peptides composed of β-, γ- and δ-amino acids can be explored to design ordered supramolecular gels and self-assembled materials. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01684DOI Listing
February 2019

Structural analysis of the terminal groups in commercial Hevea natural rubber by 2D-NMR with DOSY filters and/or multiple-WET methods using ultrahigh-field NMR.

Biomacromolecules 2019 Feb 12. Epub 2019 Feb 12.

The terminal groups of natural rubber (NR) are widely believed to play a crucial role in defining the excellent mechanical and other physical properties of processed NR products. Despite their presumed importance, the chemical structures of the terminal groups are elusive in widely used NR species with a high degree of polymerization, such as Hevea natural rubber (H-NR). In previous studies, structural analysis by solution NMR has been carried out on the terminal units of NR after chemical treatment involving chemical alterations, such as deproteinization with enzymes and other chemicals. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01771DOI Listing
February 2019

Enhancing the potency of antimicrobial peptides through molecular engineering and self-assembly.

Biomacromolecules 2019 Feb 8. Epub 2019 Feb 8.

Healthcare-associated infections resulting from bacterial attachment and biofilm formation on medical implants are posing significant challenges in particular with the emergence of bacterial resistance to antibiotics. Here, we report the design, synthesis and characterization of self-assembled nanostructures, which integrate on their surface antibacterial peptides. The antibacterial WMR peptide, which is a modification of the native sequence of the myxinidin, a marine peptide isolated from the epidermal mucus of hagfish, was used considering its enhanced activity against Gram-negative bacteria. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01740
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http://dx.doi.org/10.1021/acs.biomac.8b01740DOI Listing
February 2019
7 Reads

Enzymatically synthesized vinyl ether-disulfide monomer enabling an orthogonal combination of free radical and cationic chemistry towards sustainable functional networks.

Biomacromolecules 2019 Feb 7. Epub 2019 Feb 7.

This work demonstrates a versatile and environmentally friendly route for the development of new orthogonal monomers that can be used for post-functionalizable polymer networks. A monomer containing both vinyl ether (VE) and cyclic disulfide moieties was synthesized via enzyme catalysis under benign reaction conditions. The bifunctional monomer could be polymerized to form macromolecues with differing architectures by the use of either cationic or radical photopolymerization. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01710DOI Listing
February 2019

Modulating Thiol p K Promotes Disulfide Formation at Physiological pH: An Elegant Strategy To Design Disulfide Cross-Linked Hyaluronic Acid Hydrogels.

Biomacromolecules 2019 Feb 13. Epub 2019 Feb 13.

Translational Chemical Biology Laboratory, Division of Polymer Chemistry, Department of Chemistry-Ångstrom , Uppsala University , Uppsala 751 21 , Sweden.

The disulfide bond plays a crucial role in protein biology and has been exploited by scientists to develop antibody-drug conjugates, sensors, and for the immobilization other biomolecules to materials surfaces. In spite of its versatile use, the disulfide chemistry suffers from some inevitable limitations such as the need for basic conditions (pH > 8.5), strong oxidants, and long reaction times. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01830DOI Listing
February 2019

RGD-functionalized nanofibers increase early GFAP expression during neural differentiation of mouse embryonic stem cells.

Biomacromolecules 2019 Feb 6. Epub 2019 Feb 6.

Stem cell differentiation towards a specific lineage is controlled by its microenvironment. Polymer scaffolds have long been investigated to provide microenvironment cues; however synthetic polymers lack the specific signaling motifs necessary to direct cellular responses on their own. In this study, we fabricated random and aligned poly(ɛ-caprolactone) nanofiber substrates, surface-functionalized with RGD via strain-promoted azide-alkyne cycloaddition, that were used to investigate the role of a covalently tethered bioactive peptide (RGD) and nanofiber orientation on neural differentiation of mouse embryonic stem cells. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00018DOI Listing
February 2019

Chitosan gels and cryogels cross-linked with diglycidyl ethers of ethylene glycol and polyethylene glycol in acidic media.

Biomacromolecules 2019 Feb 6. Epub 2019 Feb 6.

Here we show that the efficacy of the chitosan interaction with diglycidyl ethers of glycols significantly depends on pH and the nature of acid used to dissolve chitosan. In solutions of hydrochloric acid, cross-linking with diglycidyl ethers of ethylene glycol (EGDGE) and polyethylene glycol (PEGDGE) at room and subzero temperatures yields mechanically stable chitosan gels and cryogels, while in acetic acid solutions only weak chitosan gels can be formed under the same conditions. Combination of elemental analysis, FT-IR spectroscopy, and solid state 13C and 15N NMR spectroscopy was used to elucidate possible differences in the mechanism of chitosan cross-linking in alkaline and acidic media at room and subzero temperatures. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01817DOI Listing
February 2019

Ring-Opening Polymerization of Hemoglobin.

Biomacromolecules 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry , Nara Medical University , 840 Shijo-cho , Kashihara 634-8521 , Japan.

Hemoglobin (Hb), an oxygen-carrying protein, has an αβ tetrameric structure that dissociates reversibly into two αβ dimers (αβ ⇄ 2αβ). We synthesized a cyclic Hb-ring monomer with two β subunits bound through a 10 kDa polyethylene glycol (PEG) chain. The monomer induced ring-opening polymerization to produce a supramolecular polymer via intersubunit interaction of αβ dimers of an Hb molecule at the PEG terminals. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01789DOI Listing
February 2019
1 Read

Effect of Peptide Sequence on the LCST-Like Transition of Elastin-Like Peptides and Elastin-Like Peptide-Collagen-Like Peptide Conjugates: Simulations and Experiments.

Biomacromolecules 2019 Feb 4. Epub 2019 Feb 4.

Elastin-like polypeptides (ELPs) are thermoresponsive biopolymers that undergo an LCST-like phase transition in aqueous solutions. The temperature of this LCST-like transition, T , can be tuned by varying the number of repeat units in the ELP, sequence and composition of the repeat units, the solution conditions, and via conjugation to other biomacromolecules. In this study, we show how and why the choice of guest (X) residue in the VPGXG pentad repeat tunes the T of short ELPs, (VPGXG), in the free state and when conjugated to collagen-like peptides (CLPs). Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01503DOI Listing
February 2019
1 Read

Fludarabine-specific molecular interactions with maltose-modified poly(propyleneimine) dendrimer enable effective cell entry of active drug form: comparison with clofarabine.

Biomacromolecules 2019 Feb 1. Epub 2019 Feb 1.

Fludarabine is an anticancer antimetabolite essential for modern chemotherapy, but its efficacy is limited due to the complex pharmacokinetics. We demonstrated the potential use of maltose-modified poly(propyleneimine) dendrimer as drug delivery agent to improve the efficiency of therapy with fludarabine. In this study, we elaborated a novel synthesis technique for radioactively-labelled fludarabine triphosphate to prove for the first time the direct ability of nucleotide-glycodendrimer complex to enter and kill leukaemic cells, without the involvement of membrane nucleoside transporters and intracellular kinases. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00010DOI Listing
February 2019
1 Read

Highly Porous Silk Fibroin Scaffold Packed in PEGDA/Sucrose Microneedles for Controllable Transdermal Drug Delivery.

Biomacromolecules 2019 Feb 11. Epub 2019 Feb 11.

Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, School of Materials and Energy , Southwest University , Chongqing 400715 , China.

Polymeric microneedles have attracted increasing attention as a minimally invasive platform for delivering drugs or vaccines in a more patient-friendly manner. However, traditional microfabrication techniques using negative molds with needle-shaped cavities usually require cumbersome centrifugation and vacuum degassing processes, which have restricted the scaled-up mass production of polymeric microneedles. Herein, a novel polydimethylsiloxane (PDMS)-based negative mold with cavities packed with silk fibroin scaffold is developed for rapid fabrication of polymeric microneedles, which comprise primarily the composition of poly(ethylene glycol) diacrylate (PEGDA) and sucrose as the needle matrix. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01715DOI Listing
February 2019
1 Read

Structural and mechanical properties of silk from different instars of Bombyx mori.

Biomacromolecules 2019 Jan 31. Epub 2019 Jan 31.

Silkworm silk has excellent mechanical properties, biocompatibility, and promising applications in biomedical sector. Silkworms spin silk at the beginning and end of each of their five instar stages, as well as spinning mature silk after the fifth instar. We evaluated the mechanical properties and structure of 10 kinds of silk fibers from different stages. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01576DOI Listing
January 2019
1 Read

Polydimethylsiloxane-Based Giant Glycosylated Polymersomes with Tunable Bacterial Affinity.

Biomacromolecules 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Pharmacy and Pharmaceutical Sciences , Monash University , Clayton , VIC 3052 , Australia.

A synthetic cell mimic in the form of giant glycosylated polymersomes (GGPs) comprised of a novel amphiphilic diblock copolymer is reported. A synthetic approach involving a poly(dimethylsiloxane) (PDMS) macro-chain transfer agent (macroCTA) and postpolymerization modification was used to marry the hydrophobic and highly flexible properties of PDMS with the biological activity of glycopolymers. 2-Bromoethyl acrylate (BEA) was first polymerized using a PDMS macroCTA ( M ≈ 4900 g·mol, Đ = 1. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01709
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http://dx.doi.org/10.1021/acs.biomac.8b01709DOI Listing
February 2019
2 Reads

Stealth Iron Oxide Nanoparticles for Organotropic Drug Targeting.

Biomacromolecules 2019 Feb 12. Epub 2019 Feb 12.

Department of Comparative Biomedicine and Food Science , University of Padua , Viale dell'Università , Legnaro , 35020 , Italy.

The ability of peculiar iron oxide nanoparticles (IONPs) to evade the immune system was investigated in vivo. The nanomaterial was provided directly into the farming water of zebrafish ( Danio rerio) and the distribution of IONPs and the delivery of oxytetracycline (OTC) was studied evidencing the successful overcoming of the intestinal barrier and the specific and prolonged (28 days) organotropic delivery of OTC to the fish ovary. Noteworthy, no sign of adverse effects was observed. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01750DOI Listing
February 2019
1 Read

Rod-Shaped Micelles Based on PHF- g-(PCL-PEG) with pH-Triggered Doxorubicin Release and Enhanced Cellular Uptake.

Biomacromolecules 2019 Feb 11. Epub 2019 Feb 11.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering , East China Normal University , Shanghai 200062 , PR China.

A biodegradable brush-type copolymer PHF- g-(PCL-PEG) based on a cleavable polyacetal backbone and biodegradable side chain modified with polyethylene glycol (PEG) was synthesized in this paper. This particular structure was directional to facilitate the formation of spherical or rod-shaped micelles. Flow cytometry showed that rod-shaped micelles displayed enhanced cellular uptake compared to spherical micelles. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01430DOI Listing
February 2019
3 Reads

Experimental and Theoretical Evaluation of the Solubility/Insolubility of Spruce Xylan (Arabino Glucuronoxylan).

Biomacromolecules 2019 Feb 8. Epub 2019 Feb 8.

School of Chemical Science and Engineering, Fibre and Polymer Technology , Royal Institute of Technology , Teknikringen 56-58 , SE-10044 Stockholm , Sweden.

The molecular solubility of softwood arabinoglucuronoxylan (AGX) has been thoroughly investigated, and it has been shown that the chemical and physical structures of the extracted hemicellulose are not significantly influenced by different purification steps, but a transient molecular solubility of AGX was observed in aqueous media at low concentrations (1 g/L) when the dissolved macromolecules had a hydrodynamic diameter of up to 10 nm. A phase separation was detected when the concentration was increased to 15 g/L leading to an association of the smaller molecules into fractal structures with a considerably larger diameter, even though the dispersions were still transparent to ocular inspection. Dynamic Light Scattering and Cryo-Transmission Electron Microscopy showed dimensions in the range of 1000 nm. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01686DOI Listing
February 2019

Quantitative Grafting for Structure-Function Establishment: Thermoresponsive Poly(alkylene oxide) Graft Copolymers Based on Hyaluronic Acid and Carboxymethylcellulose.

Biomacromolecules 2019 Feb 12. Epub 2019 Feb 12.

Department of Chemistry and Chemical Engineering, Biopolymer Technology , Chalmers University of Technology , SE-41296 Göteborg , Sweden.

A series of thermoresponsive graft copolymers, gelling at physiological conditions in aqueous solution and cell growth media, have been synthesized using quantitative coupling between a small set of amino-functionalized poly(alkylene oxide) copolymers (PAO) and the carboxylate of the biologically important polysaccharides (PSa) carboxymethylcellulose and the less reactive hyaluronate. Quantitative grafting enables the establishment of structure-function relationship which is imperative for controlling the properties of in situ gelling hydrogels. The EDC/NHS-mediated reaction was monitored using SEC-MALLS, which revealed that all PAOs were grafted onto the PSa backbone. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01692DOI Listing
February 2019
1 Read

Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.

Biomacromolecules 2019 Feb 7. Epub 2019 Feb 7.

Department of Chemistry and Biotechnology , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku , Tokyo 113-8656 , Japan.

Peptide ligation is an indispensable step in the chemical synthesis of target peptides and proteins that are difficult to synthesize at once by a solid-phase synthesis. The ligation reaction is generally conducted with two peptide fragments at a high aqueous concentration to increase the reaction rate; however, this often causes unpredictable aggregation and precipitation of starting or resulting peptides due to their hydrophobicities. Here, we have developed a novel peptide ligation strategy harnessing the two intrinsic characteristics of oligodeoxynucleotides (ODNs), i. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01655DOI Listing
February 2019

Supramolecular Tuning of HS Release from Aromatic Peptide Amphiphile Gels: Effect of Core Unit Substituents.

Biomacromolecules 2019 Feb 24;20(2):1077-1086. Epub 2019 Jan 24.

Department of Chemistry, Macromolecules Innovation Institute, and Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.

HS is a gasotransmitter with several physiological roles, but its reactivity and short half-life in biological media make its controlled delivery difficult. For biological applications of the gas, hydrogels have the potential to deliver HS with several advantages over other donor systems, including localized delivery, controlled release rates, biodegradation, and variable mechanical properties. In this study, we designed and evaluated peptide-based HS-releasing hydrogels with controllable HS delivery. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01732DOI Listing
February 2019

Nanostructural Properties and Twist Periodicity of Cellulose Nanofibrils with Variable Charge Density.

Biomacromolecules 2019 Feb 6. Epub 2019 Feb 6.

ETH Zurich , Department of Health Sciences and Technology , Schmelzbergstrasse 9, LFO E23 , 8092 , Zurich , Switzerland.

Cellulose nanofibrils (CNFs) are a renewable and facile to produce nanomaterial that recently gained a lot of attention in soft material research. The nanostructural properties of the fibrils largely determine their self-organizing functionalities, and the ability to tune the CNF nanostructure through control of the processing parameters is therefore crucial for developing new applications. In this study, we systematically altered the CNF production parameters (i. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01706DOI Listing
February 2019

Biomass-Derived Poly(ether-amide)s Incorporating Hydroxycinnamates.

Biomacromolecules 2019 Feb 23;20(2):758-766. Epub 2019 Jan 23.

Department of Bioengineering , University of California, Los Angeles , 410 Westwood Plaza , Los Angeles , California 90095 , United States.

Lignin-derived chemicals have great potential as feedstock to produce polymeric materials, due to the low cost and high abundance of lignin biomass. Lignin is one of the few nonpetroleum sources of aromatic carbon, a desirable moiety in high-performance polymers. Herein we describe the synthesis and characterization of a series of 21 poly(ether-amide)s that incorporate hydroxycinnamates derived from lignin. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00044DOI Listing
February 2019

Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers.

Biomacromolecules 2019 Feb 5. Epub 2019 Feb 5.

Department of Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Campus Universitario , Universidad de Alcalá , E-28805 Alcalá de Henares , Madrid , Spain.

The interaction of neuropeptides, vasoactive intestinal peptide (VIP), or growth hormone-releasing hormone (GHRH), with a cationic carbosilane dendrimer forms dendriplexes with antitumoral behavior in advanced prostate cancer cells PC3. At the concentrations used for dendriplexes formation, the free peptides were protumoral and prometastatic in advanced prostate cancer, while dendrimer only showed low cytotoxicity, but did not avoid the metastatic behavior of PC3 cells. However, these nanoplexes favored also cell adhesion and avoided cell migration. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01632DOI Listing
February 2019
1 Read

Peptidic Monodisperse PEG "combs" with Fine-Tunable LCST and Multiple Imaging Modalities.

Biomacromolecules 2019 Feb 5. Epub 2019 Feb 5.

Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences , Wuhan University , Wuhan 430071 , China.

Thermosensitive and imaging-traceable materials with fine-tunable lower critical solution temperature (LCST) around body temperature are highly valuable in biomedicine. However, such materials are rare because it is challenging to fine-tune the LCST and incorporate suitable imaging modalities. Herein, peptidic monodisperse polyethylene glycol (M-PEG) "combs" with fine-tunable LCST, "hot spot" fluorine-19 magnetic resonance imaging (F MRI), thermoresponsive fluorescent imaging, and drug loading ability were developed through accurately programming their structures during solid phase peptide synthesis (SPPS). Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01693DOI Listing
February 2019

Poly(l-lactide) and Poly(l-lactide- co-trimethylene carbonate) Melt-Spun Fibers: Structure-Processing-Properties Relationship.

Biomacromolecules 2019 Feb 4. Epub 2019 Feb 4.

Department of Fibre and Polymer Technology , KTH Royal Institute of Technology , 100 44 Stockholm , Sweden.

l-Lactide/trimethylene carbonate copolymers have been produced as multifilament fibers by high-speed melt-spinning. The relationship existing between the composition, processing parameters and physical properties of the fibers has been disclosed by analyzing how the industrial process induced changes at the macromolecular level, i.e. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01739DOI Listing
February 2019

Starburst Diblock Polyprodrugs: Reduction-Responsive Unimolecular Micelles with High Drug Loading and Robust Micellar Stability for Programmed Delivery of Anticancer Drugs.

Biomacromolecules 2019 Feb 1. Epub 2019 Feb 1.

Institute for Clean Energy and Advanced Materials, School of Materials and Energy , Southwest University , Chongqing , 400715 , People's Republic of China.

Polymeric prodrug based on therapeutic nanomedicine has demonstrated great promise for effective tumor growth inhibition, however, the drawbacks of low drug-loading and weak micellar stability limit its application for clinical cancer therapy. Herein, a reduction-responsive starburst block copolymer prodrug CCP [β-cyclodextrin (β-CD)-PCPT-POEGMA, XX: SS or CC] has been developed for cancer therapy. And CCP is composed of β-CD-Br core with multiple reactive sites, as well as a diblock copolymer containing hydrophobic polymerized camptothecin (PCPT) prodrug chain and hydrophilic poly[(ethylene glycol) methyl ether methacrylate] (OEGMA) chain. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01566DOI Listing
February 2019
5 Reads

Binding Forces of Cellulose Binding Modules on Cellulosic Nanomaterials.

Biomacromolecules 2019 Feb 31;20(2):769-777. Epub 2019 Jan 31.

Department of Bioproducts and Biosystems , Aalto University , Espoo, FI-00076 Aalto , Finland.

In this study, the interaction forces between different cellulosic nanomaterials and a protein domain belonging to cellulose binding modules family 1 (CBM1) were investigated at the molecular scale. Cellulose binding modules are protein domains found in carbohydrate active enzymes having an affinity toward cellulosic materials. Here, the binding force of a fusion protein containing a cellulose binding module (CBM1) produced recombinantly in E. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01346DOI Listing
February 2019
2 Reads

Synthesis and Self-Assembly of Double-Hydrophilic and Amphiphilic Block Glycopolymers.

Biomacromolecules 2019 Feb 6. Epub 2019 Feb 6.

Macromolecular Chemistry and New Polymeric Materials, Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 4 , 9747 AG Groningen , The Netherlands.

In this report, we present double-hydrophilic block glycopolymers of poly(2-hydroxyethyl methacrylate)- b-poly(2-(β-glucosyloxy)ethyl methacrylate) (PHEMA- b-PGEMA) and amphiphilic block glycopolymers of poly(ethyl methacrylate)- b-PGEMA (PEMA- b-PGEMA) synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The block glycopolymers were prepared in two compositions of P(H)EMA macro-chain transfer agents (CTAs) and similar molecular weights of PGEMA. Structural analysis of the resulting polymers as well as the conversion of (H)EMA and GEMA monomers were determined by H NMR spectroscopy. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01713DOI Listing
February 2019
2 Reads

Cooperation of helix insertion and lateral pressure to remodel membranes.

Biomacromolecules 2019 Jan 17. Epub 2019 Jan 17.

Nature has developed different protein mediated mechanisms to remodel cellular membranes. One of the proteins that is implicated in these processes is α-synuclein (αS). Here we investigate if besides αS's membrane bound amphipathic helix the disordered, solvent exposed tail of the protein contributes to membrane reshaping. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01606DOI Listing
January 2019
2 Reads

Molecular Sieving on the Surface of a Nano-Armored Protein.

Biomacromolecules 2019 Feb 4. Epub 2019 Feb 4.

Department of Biological Sciences , Carnegie Mellon University , 4400 Fifth Avenue , Pittsburgh , Pennsylvania 15213 , United States.

The molecular sieving properties of protein surface-attached polymers are the central features in how polymers extend therapeutic protein lifetimes in vivo. Yet, even after 30 years of research, permeation rates of molecules through polymer-surrounded protein surfaces are largely unknown. As a result, the generation of protein-polymer conjugates remains a stochastic process, unfacilitated by knowledge of structure-function-polymer architecture relationships. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01651
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http://dx.doi.org/10.1021/acs.biomac.8b01651DOI Listing
February 2019
6 Reads

Cancer Selective Turn-On Fluorescence Imaging Using a Biopolymeric Nanocarrier.

Biomacromolecules 2019 Feb 30;20(2):1068-1076. Epub 2019 Jan 30.

Program in Nanoscience and Technology, Graduate School of Convergence Science and Technology , Seoul National University , Seoul , 08826 Republic of Korea.

Most nanoparticle-based bioresearch for clinical applications is unable to overcome the clinical barriers of efficacy (e.g., sensitivity and selectivity), safety for human use, and scalability for mass-production processes. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01690DOI Listing
February 2019
3 Reads

Celebrating 20 years of Biomacromolecules!

Biomacromolecules 2019 Feb 15;20(2):767-768. Epub 2019 Jan 15.

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http://dx.doi.org/10.1021/acs.biomac.8b01782DOI Listing
February 2019
2 Reads

Design and Synthesis of PEG-Oligoglycerol Sulfates as Multivalent Inhibitors for the Scavenger Receptor LOX-1.

Biomacromolecules 2019 Feb 4. Epub 2019 Feb 4.

Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité-Universitätsmedizin Berlin , Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1 , 13353 Berlin , Germany.

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a cell surface scavenger receptor. The protein is involved in binding and internalization of oxidized low-density lipoprotein (oxLDL), which leads under pathophysiological circumstances to plaque formation in arteries and initiation of atherosclerosis. A structural feature of LOX-1 relevant to oxLDL binding is the "basic spine" motif consisting of linearly aligned arginine residues stretched over the dimer surface. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01416DOI Listing
February 2019
2 Reads

Insights into siRNA Transfection in Suspension: Efficient Gene Silencing in Human Mesenchymal Stem Cells Encapsulated in Hyaluronic Acid Hydrogel.

Biomacromolecules 2019 Feb 8. Epub 2019 Feb 8.

Translational Chemical Biology Laboratory, Polymer Chemistry Division, Department of Chemistry - Ångström Laboratory , Uppsala University , 751 21 Uppsala , Sweden.

Small interfering RNAs (siRNAs) are powerful tools for post-transcriptional gene silencing, which offers enormous opportunities for tissue engineering applications. However, poor serum stability, inefficient intracellular delivery, and inevitable toxicity of transfection reagents are the key barriers for their clinical translation. Thus, innovative strategies that allow safe and efficient intracellular delivery of the nucleic acid drugs at the desired site is urgently needed for a smooth clinical translation of therapeutically appealing siRNA-based technology. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01712DOI Listing
February 2019
2 Reads

Oxygen-Releasing Microparticles for Cell Survival and Differentiation Ability under Hypoxia for Effective Bone Regeneration.

Biomacromolecules 2019 Feb 28;20(2):1087-1097. Epub 2019 Jan 28.

Department of Nanobiomedical Science , Dankook University , Cheonan 31116 , Republic of Korea.

Sufficient oxygen delivery into tissue-engineered three-dimensional (3D) scaffolds to produce clinically applicable tissues/organs remains a challenge for researchers and clinicians. One potential strategy to overcome this limitation is the use of an oxygen releasing scaffold. In the present study, we prepared hollow microparticles (HPs) loaded with an emulsion of the oxygen carrier perfluorooctane (PFO; PFO-HPs) for the timely supply of oxygen to surrounding cells. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01760DOI Listing
February 2019
1 Read

Ligand-Binding Cooperativity Effects in Polymer-Protein Conjugation.

Biomacromolecules 2019 Feb 29;20(2):1118-1131. Epub 2019 Jan 29.

Institute of Chemistry , Martin Luther University Halle-Wittenberg , Von-Danckelmann-Platz 4 , 06120 Halle (Saale) , Germany.

We present an electron paramagnetic resonance (EPR) spectroscopic characterization of structural and dynamic effects that stem from post-translational modifications of bovine serum albumin (BSA), an established model system for polymer-protein conjugation. Beyond the typical drug delivery and biocompatibility aspect of such systems, we illustrate the causes that alter internal dynamics and therefore functionality in terms of ligand-binding to the BSA protein core. Uptake of the paramagnetic fatty acid derivative 16-doxyl stearic acid by several BSA-based squaric acid macroinitiators and polymer-protein conjugates was studied by EPR spectroscopy, aided by dynamic light scattering (DLS) and zeta potential measurements. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00016DOI Listing
February 2019
2 Reads

Synthesis of Antibacterial Glycosylated Polycaprolactones Bearing Imidazoliums with Reduced Hemolytic Activity.

Biomacromolecules 2019 Feb 10;20(2):949-958. Epub 2019 Jan 10.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences , Nanyang Technological University , 21 Nanyang Link , Singapore 637371 , Republic of Singapore.

Most synthetic antimicrobial polymers are not biodegradable, thus limiting their potential for large-scale applications in personal care disinfection and environmental contaminations. Poly(ε-caprolactone) (PCL) is known to be both biodegradable and biocompatible, thus representing an ideal candidate biopolymer for antimicrobial applications. Here we successfully grafted alkylimidazolium (Im) onto PCL to mimic the cationic properties of antimicrobial peptides. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01577DOI Listing
February 2019
3 Reads

A highly efficient fluorescent material based on rare-earth-modified polyhydroxyalkanoates.

Biomacromolecules 2019 Jan 9. Epub 2019 Jan 9.

Fluorescent materials play an important role in biomedical fields. However, the main types of fluorescent materials suffer from several disadvantages especially the biotoxicity, which largely restrict its wider applications in biological fields. In this study, a highly efficient rare-earth-modified fluorescent material was successfully designed and fabricated based on polyhydroxyalkanoates, which are known as biodegradable and biocompatible material. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01722DOI Listing
January 2019
5 Reads
5.750 Impact Factor

Fabrication of Cellulose-Nanocrystal-Based Folate Targeted Nanomedicine via Layer-by-Layer Assembly with Lysosomal pH-Controlled Drug Release into the Nucleus.

Biomacromolecules 2019 Feb 22;20(2):937-948. Epub 2019 Jan 22.

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering , East China Normal University , Shanghai 200062 , PR China.

To increase the cellular uptake and drug loading of cellulose nanocrystal (CNC)-based nanomedicines, folate/ cis-aconityl-doxorubicin@polyethylenimine@CNC (FA/CAD@PEI@CNC) nanomedicines were built up by the building blocks of folate (FA), cis-aconityl-doxorubicin (CAD), polyethylenimine (PEI), and CNCs via the robust layer-by-layer (LbL) assembly technique. The drug loading content (DLC) of FA/CAD@PEI@CNC hybrids was 11.3 wt %, which was almost 20-fold higher than that of the CNC-based nano-prodrug we reported previously. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01556DOI Listing
February 2019
1 Read
5.750 Impact Factor

Tumor Microenvironmental pH and Enzyme Dual Responsive Polymer-Liposomes for Synergistic Treatment of Cancer Immuno-Chemotherapy.

Biomacromolecules 2019 Feb 18;20(2):882-892. Epub 2019 Jan 18.

CAS Center for Excellence in Nanoscience CAS Laboratory for Biomedical Effects of Nanomaterials and Nanosafety , National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao , Zhongguancun, Beijing , China.

Despite recent advances in tumor treatment through cancer immunotherapy, the efficacy of this approach remains to be improved. Looking forward to high rates of objective clinical response, cancer immunotherapy combined with chemotherapy has gained increasing attention recently. Here, we constructed liposomes with matrix metalloproteinases (MMPs) responsive moiety and PD-L1 inhibitor conjugate combine with low dose chemotherapy to achieve enhanced antitumor efficacy. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01510
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http://dx.doi.org/10.1021/acs.biomac.8b01510DOI Listing
February 2019
6 Reads

Coupling Self-Assembly Mechanisms to Fabricate Molecularly and Electrically Responsive Films.

Biomacromolecules 2019 Feb 22;20(2):969-978. Epub 2019 Jan 22.

Institute for Bioscience and Biotechnology Research , University of Maryland , College Park , Maryland 20742 , United States.

Biomacromolecules often possess information to self-assemble through low energy competing interactions which can make self-assembly responsive to environmental cues and can also confer dynamic properties. Here, we coupled self-assembling systems to create biofunctional multilayer films that can be cued to disassemble through either molecular or electrical signals. To create functional multilayers, we: (i) electrodeposited the pH-responsive self-assembling aminopolysaccharide chitosan, (ii) allowed the lectin Concanavalin A (ConA) to bind to the chitosan-coated electrode (presumably through electrostatic interactions), (iii) performed layer-by-layer self-assembly by sequential contacting with glycogen and ConA, and (iv) conferred biological (i. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01592
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http://dx.doi.org/10.1021/acs.biomac.8b01592DOI Listing
February 2019
5 Reads

Membrane-Binding Adhesive Particulates Enhance the Viability and Paracrine Function of Mesenchymal Cells for Cell-Based Therapy.

Biomacromolecules 2019 Feb 18;20(2):1007-1017. Epub 2019 Jan 18.

Department of Biomedical Engineering, College of Engineering , Peking University Room 206, Fangzheng Building, 298 Chengfu Road , Haidian District, Beijing 100871 , China.

Understanding the fundamental cell-material interactions is essential to designing functional materials for biomedical applications. Although mesenchymal stromal cells (MSCs) are known to secrete cytokines and exosomes that are effective to treat degenerative diseases, the inherent property of biomaterials to modulate the therapeutic function of MSCs remains to be investigated. Here, a multivalent cell-membrane adhesive conjugate was generated through polyamindoamine (PAMAM) and an oligopeptide, IKVAV, and the conjugate was further complexed with hyaluronic acid (HA). Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01624
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http://dx.doi.org/10.1021/acs.biomac.8b01624DOI Listing
February 2019
9 Reads
5.750 Impact Factor

Sustainable Chitin Nanofibrils Provide Outstanding Flame-Retardant Nanopapers.

Biomacromolecules 2019 Feb 22;20(2):1098-1108. Epub 2019 Jan 22.

Institute for Macromolecular Chemistry , Stefan-Meier-Strasse 31, University of Freiburg , 79104 Freiburg , Germany.

Sustainable polysaccharide nanofibrils formed from chitin or cellulose are emerging biobased nanomaterials for advanced materials requiring high mechanical performance, barrier properties, for bioactive materials, or other functionalities. Here, we demonstrate a single-step, waterborne approach to prepare additive-free flame-retardant and self-extinguishing, mechanical high-performance nanopapers based purely on surface-deacetylated chitin nanofibrils (ChNFs). We show that the flammability can be critically reduced by exchanging the counterions, e. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01766DOI Listing
February 2019
3 Reads

Chemoselective, Postpolymerization Modification of Bioactive, Degradable Polymers.

Biomacromolecules 2019 Feb 22;20(2):1018-1027. Epub 2019 Jan 22.

Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

Degradable polymers promote sustainability, mitigate environmental impact, and facilitate biological applications. Tailoring degradable polymers is challenging because installing functional group-rich side chains is difficult when the backbone itself is susceptible to degradation. A convenient means of side chain installation is through postpolymerization modification (PPM). Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01631DOI Listing
February 2019
2 Reads