8,299 results match your criteria Biomacromolecules [Journal]


Influence of size and cross-linking density of microgels on cellular uptake and uptake kinetics.

Biomacromolecules 2020 May 27. Epub 2020 May 27.

The unique pH and temperature responsiveness of PNIPAM-based microgels make them a promising target for novel biomedical applications such as cellular drug delivery systems. However, we lack a comprehensive understanding of how the physico-chemical properties of microgels relate to their interaction with cells. Here, we show that HEK293T cells take up PNIPAM-based microgels on a second-to-minute time scale. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00478DOI Listing

Zwitterion Surface-functionalized Thermoplastic Polyurethane for Antifouling Catheter Applications.

Biomacromolecules 2020 May 27. Epub 2020 May 27.

Immobilizing zwitterionic molecules on material surfaces has been a promising strategy for creating antifouling surfaces. Herein, we show the ability to surface derivatize an allyl ether functionalized thermoplastic polyurethane (TPU) with a zwitterionic thiol in a radically-induced thiol-ene reaction. The thermoplastic polyurethane was synthesized to have an allyl ether side functionality using a modified chain extender molecule. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00456DOI Listing

The balance between the hemostatic effect and immune response of hyaluronan conjugated with different chain lengths of inorganic polyphosphate.

Biomacromolecules 2020 May 26. Epub 2020 May 26.

Inorganic polyphosphate (PolyP) is a potential hemostatic material. However, the effect of PolyP chain length on the immune response and hemostatic function remains to be established. We have developed PolyP-conjugated hyaluronans (HA-PolyPs) with three different short-chain PolyPs (n = 13, 40, and 100 phosphate units). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00390DOI Listing

Removable biobased waterborne Pressure-Sensitive Adhesives containing mixtures of isosorbide methacrylate monomers.

Biomacromolecules 2020 May 22. Epub 2020 May 22.

Growing environmental concerns are enforcing sustainable recycling processes for glass substrates, especially bottles, where a fast cleaning and minimization of the use of solvents is desired. In this process, labels and adhesives are mostly removed by the addition of harsh reagents, alkaline solutions or high temperature conditions, increasing economic costs and harming the environment. Herein, high performance and biobased waterborne pressure-sensitive adhesives with fast removability in water have been developed using small percentages of isosorbide (glucose derivative) based methacrylate monomers. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00474DOI Listing

Analysis of cytoplasmic and membrane molecular crowding in genetically programmed synthetic cells.

Biomacromolecules 2020 May 22. Epub 2020 May 22.

Building genetically programmed synthetic cell systems by molecular integration is a powerful and effective approach to capture the synergies between biomolecules when they are put together. In this work, we characterized quantitatively the effects of molecular crowding on gene expression in the cytoplasm of minimal cells, when a crowding agent is added to the reaction, and on protein self-assembly at the membrane, when a crowding agent is attached to the lipid bilayer. We demonstrate that achieving membrane crowding only is sufficient to keep cytoplasmic expression at its highest and to promote the polymerization of the MreB cytoskeletal protein at the lipid bilayer into a network mechanically sturdy. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00513DOI Listing

Stabilization of Near-Infrared Fluorescent Proteins by Packaging in Virus-like Particles.

Biomacromolecules 2020 May 22. Epub 2020 May 22.

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30306, United States.

Near-IR fluorescent Qβ virus-like particles (VLPs) were produced in a high yield by packaging highly red-shifted monomeric and dimeric versions of biliverdin-dependent fluorescent proteins within the capsid shell. The simple addition of biliverdin hydrochloride to the medium during or after protein expression was enough to produce fully matured encapsidated fluorophores. The packaged near-IR proteins exhibited identical photochemical properties to their nonencapsidated analogues but were far more stable toward heat, chaotrope-induced denaturation, and proteolysis. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00362DOI Listing

Carbohydrate-functionalized Collagen Hydrogels Modulate the Glycoenviroment of a Neuronal Primary Culture.

Biomacromolecules 2020 May 20. Epub 2020 May 20.

Glycans play a central role in the development and homeostasis of the central nervous system (CNS), so changes in the glycosylation profile of cell surface and extracellular matrix (ECM) components are evident in CNS disorders. Regenerative medicine-based strategies using biomaterial platforms are being increasingly used to target these diseases and to study the glyco-signature of physiological and pathological conditions, particularly through the use of biomaterials able to recapitulate natural components and physical organization of the ECM. Collagen hydrogels have shown potential as a vehicle for the delivery of cells into the brain and their therapeutic effect can be expanded by functionalizing them to address the glycosylation patterns altered with specific brain disorders. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00387DOI Listing

Dual peptide-based gene delivery system for the efficient transfection of plant callus cells.

Biomacromolecules 2020 May 20. Epub 2020 May 20.

Owing to their diverse functions and tunable physicochemical properties, peptides are promising alternatives to the conventional gene delivery tools that are available for plant systems. However, peptide-mediated gene delivery is limited by low transfection efficiency in plants because of the insufficient cytosolic translocation of DNA cargo. Here, we report a dual peptide-based gene delivery system for the efficient transfection of plant callus cells. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00481DOI Listing

Temperature sensing in cells using polymeric upconversion nanocapsules.

Biomacromolecules 2020 May 20. Epub 2020 May 20.

Monitoring local temperature inside cells is crucial when interpreting biological activities as enhanced cellular metabolism leads to higher heat production and is commonly correlated with the presence of diseases such as cancer. In this study, we report on polymeric upconversion nanocapsules for potential use as local nano-thermometers in cells by exploiting the temperature dependence of the triplet-triplet annihilation upconversion phenomenon. Nanocapsules synthesized by the miniemulsion solvent evaporation technique are composed of a polymer shell and a liquid core of rice bran oil, hosting triplet-triplet annihilation upconversion active dyes as sensitizer and emitter molecules. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00377DOI Listing

Dual Catalytic Ring-Opening Polymerization of Ethylene Carbonate for the Preparation of Degradable PEG.

Biomacromolecules 2020 May 18. Epub 2020 May 18.

A dual catalytic setup, consisting of a range of different Lewis bases (including N-heterocyclic olefins, phosphazenes and nitrogen bases) and simple Lewis acids (such as LiCl, MgF2, BEt3) was employed to prepare poly(ether carbonate)s from five-membered, cyclic ethylene carbonate (EC). Polymerizations were conducted under microwave irradiation at T = 160-200°C with low catalyst loading (0.4 - 0. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00360DOI Listing

Fucoidan immobilized at the surface of a fibrous mesh presents toxic effects over melanoma cells, but not over non-cancer skin cells.

Biomacromolecules 2020 May 18. Epub 2020 May 18.

The use of fucoidan, a marine-origin bioactive polymer, is herein proposed as a component of an innovative and effective strategy against melanoma, one of the rarest but most aggressive skin cancers. First, fucoidan antitumor activity, in its soluble form, was assessed presenting increased cytotoxicity over melanoma cells, when compared to human dermal fibroblasts and keratinocytes. After this antitumor activity validation and trying to develop a more targeted and local strategy aiming to diminish the cytotoxic effects over non-cancer cells, fucoidan was immobilized at the surface of electrospun nanofibrous mesh (Fu_NFM), envisioning the development of a therapeutic patch. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00482DOI Listing

Aromatic stacking facilitated self-assembly of ultra-short ionic complementary peptide sequence: β-sheet nanofibres with remarkable gelation and interfacial properties.

Biomacromolecules 2020 May 13. Epub 2020 May 13.

Understanding peptide self-assembly mechanisms and stability of the formed assemblies is crucial for development of functional nanomaterials. Herein, we have adopted rational design approach to demonstrate how minimal structural modification to a non-assembling ultra-short ionic self-complementary tetrapeptide EK (Phe4) remarkably enhanced stability of self-assembly into β-sheet nanofibres and induced hydrogelation. This was achieved by replacing flexible phenylalanine residue () by the rigid phenylglycine () resulting in constrained analogue EK (Phg4), which positioned aromatic rings in an orientation favourable for aromatic stacking. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00366DOI Listing

PCL-Based Shape Memory Polymer Semi-IPNs: The Role of Miscibility in Tuning the Degradation Rate.

Biomacromolecules 2020 May 22. Epub 2020 May 22.

Department of Biomedical Engineering, Texas A&M University, College Station Texas 77843, United States.

The utility of poly(ε-caprolactone) (PCL) as a shape memory polymer (SMP) may be improved by accelerating its degradation. Recently, we have reported novel semi-interpenetrating networks (semi-IPNs) composed of cross-linked PCL diacrylate (PCL-DA) and thermoplastic poly(l-lactic acid) (PLLA) that exhibited SMP behavior, accelerated degradation, and enhanced moduli versus the PCL-DA control. Herein, we systematically varied the thermoplastic component of the PCL-based semi-IPNs, incorporating homo- and copolymers based on lactic acid of different , hydrophilicity, and crystallinity. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00454DOI Listing

Versatile bioconjugation strategies of PEG-modified upconversion nanoparticles for bioanalytical applications.

Biomacromolecules 2020 May 11. Epub 2020 May 11.

Lanthanide-doped upconversion nanoparticles (UCNPs) display highly beneficial photophysical features for background-free bioimaging and bioanalysis; however, they are instable in high ionic strength buffers, have no functional groups, and are non-specifically interacting. Here, we have prepared NIR-excitable UCNPs that are long-term colloidally stable in buffered media and possess functional groups. Heterobifunctional poly(ethylene glycol) (PEG) linkers bearing neridronate and alkyne or maleimide were attached to UCNPs via a ligand exchange. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00459DOI Listing

Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing.

Biomacromolecules 2020 May;21(5):1841-1852

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

As the abuse of antibiotics continues to increase, the emergence of antibiotic resistance and unknown drug-resistant bacterial infections pose a great threat on people worldwide. In this work, we aimed to develop a series of injectable antimicrobial conductive hydrogels based on glycidyl methacrylate functionalized quaternized chitosan (QCSG), gelatin methacrylate (GM), and graphene oxide (GO) for drug-resistant bacterial disinfection and infectious wound healing. The rheology, morphology, mechanical properties, and electrical and photothermal properties of the hydrogels were characterized. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01732DOI Listing

Renewable Molecules & Materials: Anselme Payen Award Symposium in Honor of Ann-Christine Albertsson.

Biomacromolecules 2020 May;21(5):1647-1652

Chemistry, Temple University, Philadelphia, Pennsylvania, United States.

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http://dx.doi.org/10.1021/acs.biomac.0c00507DOI Listing

Cyclic RGD-Conjugated Hyaluronate Dot Bearing Cleavable Doxorubicin for Multivalent Tumor Targeting.

Biomacromolecules 2020 May 20. Epub 2020 May 20.

Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon, Gyeonggi-do 14662, Republic of Korea.

In this study, we developed an extremely small-sized water-soluble hyaluronate dot (dHA) conjugated with cyclic RGD (cRGD) and cleavable doxorubicin (DOX, as a model antitumor drug), named cRGD@dHA-c-DOX. This dot with HA moieties (as specific ligands to tumor CD44 receptors) and cRGD moieties (as specific ligands to tumor integrin αβ) was designed to enable multivalent tumor targeting. In particular, the imine bonds, linking the DOX and dHA, can exhibit cleavage performance at endosomal pH, resulting in pH-triggered DOX release from cRGD@dHA-c-DOX. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00554DOI Listing

Targeting CD4+ Cells with Anti-CD4 Conjugated Mertansine Loaded Nanogels.

Biomacromolecules 2020 May 8. Epub 2020 May 8.

CD4+ T lymphocytes play an important role in controlling many malignancies. The modulation of CD4+ T cells through immunomodulatory or cytotoxic drugs could change the course of disease progression for disorders such as autoimmunity, immunodeficiency, and cancer. Here, we demonstrate that anti-CD4 conjugated polymeric nanogels can deliver a small molecule cargo to primary CD4+ T cells and a CD4high T cell lymphoma. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00442DOI Listing

Design of Thermoresponsive Elastin-Like Glycopolypeptides for Selective Lectin Binding and Sorting.

Biomacromolecules 2020 May 26. Epub 2020 May 26.

Univ. Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, Pessac, F-33600, France.

Selective lectin binding and sorting was achieved using thermosensitive glycoconjugates derived from recombinant elastin-like polypeptides (ELPs) in simple centrifugation-precipitation assays. A recombinant ELP, (VPGXG), containing periodically spaced methionine residues was used to enable chemoselective postsynthetic modification via thioether alkylation using alkyne functional epoxide derivatives. The resulting sulfonium groups were selectively demethylated to give alkyne functionalized homocysteine residues, which were then reacted with azido-functionalized monosaccharides to obtain ELP glycoconjugates with periodic saccharide functionality. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00374DOI Listing

Synthesis and Characterization of a Leucine-Based Block Co-Polypeptide: The Effect of the Leucine Zipper on Self-Assembly.

Biomacromolecules 2020 May 7. Epub 2020 May 7.

George & Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science & Engineering, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States.

The self-assembly behavior of an ABC triblock copolypeptide consisting of poly(ethylene oxide--(leucine--valine)--lysine) (PEO-PLV-PK) was examined via dynamic light scattering in dilute aqueous solution. Leucine is a hydrophobic, α-helix forming polypeptide that exhibits a "zipper effect" in coiled-coil dimers. We hypothesize that the specific interaction afforded by the leucine zipper dominates the thermodynamics of self-assembly through the side-by-side ordering of α-helices, which drives vesicle formation in a polymer with only 6 wt % hydrophobic content. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00420DOI Listing

Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency.

Biomacromolecules 2020 May 6. Epub 2020 May 6.

Cytokine signaling is challenging to study and therapeutically exploit as the effects of these protein are often pleiotropic. A subset of cytokines can, however, achieve signal specificity via association with latency-inducing proteins which cage the cytokine until disrupted by discreet biological stimuli. Inspired by this precision, here we describe a strategy for synthetic induction of cytokine latency via modification with photo-labile polymers that mimic latency while attached, then restore protein activity in response to light, thus controlling the magnitude, duration, and location of cytokine signals. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00264DOI Listing

Main-Chain Liquid Crystalline Hydrogels that Support 3D Stem Cell Culture.

Biomacromolecules 2020 May 19. Epub 2020 May 19.

Chemical and Biomolecular Engineering, University of Connecticut, 191 Auditorium Road Unit 3222, Storrs, Connecticut 06269-3222, United States.

Hydrogels are frequently utilized as three-dimensional matrices for the culture and regeneration of soft tissues, but one challenge with the existing hydrogels is that, though the natural extracellular matrix of tissues may be ordered, there are few biocompatible ways to incorporate anisotropy within hydrogels. Liquid crystalline (LC) polymers are well suited for this because of their combination of molecular ordering and polymer elasticity; however, the hydrophobic nature of LC monomers has hindered their polymerization into hydrogels under cytocompatible conditions. This work reports on the generation of main-chain LC hydrogels in aqueous media and the ability of LC phases to affect mesenchymal stem cell behavior. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00316DOI Listing

Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin.

Biomacromolecules 2020 May 5. Epub 2020 May 5.

Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, United States.

Polymers that stabilize biomolecules are important as excipients in protein formulation. Herein, we describe a class of degradable polymers that have tunable degradation rates depending on the polymer backbone and can stabilize proteins to aggregation. Specifically, zwitterion- and trehalose-substituted polycaprolactone, polyvalerolactone, polycarbonate, and polylactide were prepared and characterized with regards to their hydrolytic degradation and ability to stabilize insulin to mechanical agitation during heat. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00133DOI Listing

Graft Modification of Starch Nanoparticles Using Nitroxide-Mediated Polymerization and the "Grafting to" Approach.

Biomacromolecules 2020 May 14. Epub 2020 May 14.

Department of Chemical Engineering, Queen's University, 19 Division Street, Kingston, Ontario K7L 3N6, Canada.

Starch nanoparticles (SNP) were modified with synthetic polymers using the "grafting to" approach and nitroxide-mediated polymerization. SG1-capped poly(methyl methacrylate--styrene) (P(MMA--S)) copolymers with low dispersity and high degree of livingness were first synthesized in bulk. These macroalkoxyamines were then grafted to vinyl benzyl-functionalized SNP to obtain biosynthetic hybrids. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00462DOI Listing

Chiral Nematic Liquid Crystal Behavior of Core-Shell Hybrid Rods Consisting of Chiral Cellulose Nanocrystals Dressed with Non-chiral Conformal Polymeric Skins.

Biomacromolecules 2020 May 14. Epub 2020 May 14.

Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 300071 Tianjin, China.

The current work investigates how the nanoscale conformal coating layers of non-chiral polymeric materials can influence the chiral nematic liquid crystal (CLC) behaviors of the rodlike cellulose nanocrystals (CNCs), the bio-derived nanomaterials that have attracted significant attention. For this, we developed strategies to coat the CNC rods on the single-particle level with a homogeneous bioinspired polydopamine (PDA) layer, leading to well-defined core-shell CNC@PDA rods with various PDA coating thicknesses and excellent colloidal stability. Comprehensive investigation revealed that the CNC@PDA hybrid nanorods in concentrated suspensions form well-defined nematic liquid crystal phases with clear phase separation behavior that depend on the rod concentrations and ionic strengths, typical of charged rods. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00320DOI Listing

Salt-Induced Shape-Memory Effect in Gelatin-Based Hydrogels.

Biomacromolecules 2020 May 18. Epub 2020 May 18.

Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany.

Hydrophilic biopolymers display a strong tendency for self-organization into stable secondary, tertiary, and quaternary structures in aqueous environments. These structures are sensitive to changes in external conditions, such as temperature, pH or ions/salts, which may lead to molecular and/or macroscopic transitions. Here, we report on biopolymer-based stimuli-sensitive switchable matrices showing a shape-memory function as an output being alternatively switched by two different input signals, such as environmental changes in salt concentration or temperature. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01753DOI Listing

Functionalization of Cellulose Nanocrystals with POEGMA Copolymers via Copper-Catalyzed Azide-Alkyne Cycloaddition for Potential Drug-Delivery Applications.

Biomacromolecules 2020 May 4. Epub 2020 May 4.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 1H6, Canada.

Elongated colloidal nanoparticles (NPs) have significant potential for drug delivery and imaging applications in cancer therapy, but progress depends on developing a deeper understanding of how their physicochemical properties affect their interactions with cells and with tumors. Cellulose nanocrystals (CNCs) are biocompatible, rodlike colloids that are broadly surface-functionalizable, making them interesting as modular drug carriers. In this report, we describe the attachment of a statistical copolymer containing oligoethylene glycol methacrylate (OEGMA; ≈ 500 Da) and small amounts of aminopropylmethacrylamide (APMA) to CNCs. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01713DOI Listing

Revisiting Cationic Phosphorus Dendrimers as a Nonviral Vector for Optimized Gene Delivery Toward Cancer Therapy Applications.

Biomacromolecules 2020 May 11. Epub 2020 May 11.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.

Gene delivery, one important cancer-therapy mode, still remains to be challenging because of the shortage of highly efficient and safe nonviral vectors. Here, we revisit the development of cationic phosphorus dendrimers by synthesizing them with different generations (G1-3) and surface ligands (1-(2-aminoethyl) pyrrolidine, 1-(3-aminopropyl) piperidine, or 1-(2-aminoethyl) piperidine) for optimized gene delivery toward cancer-gene-therapy applications. First, the synthesized dendrimer derivatives were employed to condense plasmid DNA (pDNA) encoding enhanced green fluorescent protein (EGFP) to optimize their gene-delivery efficiency by varying the dendrimer generations and surface polycationic ligands. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00458DOI Listing

Fabrication of Biohybrid Cellulose Acetate-Collagen Bilayer Matrices as Nanofibrous Spongy Dressing Material for Wound-Healing Application.

Biomacromolecules 2020 May 11. Epub 2020 May 11.

Laboratory of Fibre and Cellulose Technology, Abo Akademi University, Porthansgatan 3, FI-20500 Abo, Finland.

Tissue engineering is currently one the fastest growing engineering fields, requiring fabrication of advanced and multifunctional materials to be used as scaffolds or dressing for tissue regeneration. In this work, a bilayer matrix was fabricated by electrospinning of a hybrid cellulose acetate nanofibers (CA) containing bioactive latex or Ciprofloxacin over highly interconnected collagen (CSPG) 3D matrix previously obtained by a freeze-drying process. The bilayer matrix was fabricated with a nanofibrous part as the primary (top) layer and a spongy porous part as the secondary (bottom) layer by combining electrospinning and freeze-drying techniques to enhance the synergistic effect of both materials corresponding to physical and biological properties. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00516DOI Listing

Phase-Separated Multienzyme Biosynthesis.

Biomacromolecules 2020 May 5. Epub 2020 May 5.

Department of Chemistry, School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

Liquid-liquid phase separation forms condensates that feature a highly concentrated liquid phase, a defined yet dynamic boundary, and dynamic exchange at and across the boundary. Phase transition drives the formation of dynamic multienzyme complexes in cells, for example, the purinosome, which forms subcellular macrobodies responsible for purine biosynthesis. Here, we construct synthetic versions of multienzyme biosynthetic systems by assembling enzymes in protein condensates. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00321DOI Listing

Cellulose Nanocrystal Reinforced Collagen-Based Nanocomposite Hydrogel with Self-Healing and Stress-Relaxation Properties for Cell Delivery.

Biomacromolecules 2020 May 11. Epub 2020 May 11.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.

While injectable cross-linking collagen hydrogels offer great potential for applying stem cell therapy to regenerate articular cartilage minimally invasive procedures, the encapsulated cells experience high shear stress during injection, which results in limited cell survival. In this study, surface-modified cellulose nanocrystals (CNCs) have been investigated as green and biocompatible reinforcing agents for collagen hydrogel. Aldehyde-functionalized CNCs (a-CNCs) were produced through a facile one-pot oxidation. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00345DOI Listing

Direct Comparison of Poly(ethylene glycol) and Phosphorylcholine Drug-Loaded Nanoparticles In Vitro and In Vivo.

Biomacromolecules 2020 May 12. Epub 2020 May 12.

Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.

Phosphorylcholine is known to repel the absorption of proteins onto surfaces, which can prevent the formation of a protein corona on the surface of nanoparticles. This can influence the fate of nanoparticles used for drug delivery. This material could therefore serve as an alternative to poly(ethylene glycol) (PEG). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00257DOI Listing

Amphiphilic Star Polypept(o)ides as Nanomeric Vectors in Mucosal Drug Delivery.

Biomacromolecules 2020 May 7. Epub 2020 May 7.

Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin D02, Ireland.

Mucosal delivery across the gastrointestinal (GI) tract, airways, and buccal epithelia is an attractive mode of therapeutic administration, but the challenge is to overcome the mucus and epithelial barriers. Here, we present degradable star polypept(o)ides capable of permeating both barriers as a promising biomaterial platform for mucosal delivery. Star polypept(o)ides were obtained by the initiation of benzyl-l-glutamate -carboxyanhydride (NCA) from an 8-arm poly(propyleneimine) (PPI) dendrimer, with subsequent chain extension with sarcosine NCA. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00381DOI Listing

A6 Peptide-Tagged Core-Disulfide-Cross-Linked Micelles for Targeted Delivery of Proteasome Inhibitor Carfilzomib to Multiple Myeloma In Vivo.

Biomacromolecules 2020 May 5. Epub 2020 May 5.

Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, People's Republic of China.

Carfilzomib (CFZ) is a second-generation proteasome inhibitor approved for treating relapsed/refractory multiple myeloma (MM). The clinical formulation utilizing sulfobutylether-β-cyclodextrin to solubilize CFZ (Captisol, CFZ-CD) shows, however, short circulation time, lack of cell selectivity, and unmet antitumor efficacy. Here, we designed and prepared A6 peptide (sequence: KPSSPPEE)-tagged core-disulfide-cross-linked biodegradable micelles (A6-PMs) for targeted CFZ therapy of CD44-overexpressing LP-1 human MM in vivo. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01790DOI Listing

Development and Characterization of Calmodulin-Based Copolymeric Hydrogels.

Biomacromolecules 2020 Apr 22. Epub 2020 Apr 22.

Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi 38677, United States.

Recently, there has been growing interest in harnessing genetically engineered polymers to develop responsive biomaterials, such as hydrogels. Unlike their synthetic counterparts, genetically engineered polymers are produced without the use of toxic reagents and can easily be programmed to incorporate desirable hydrogel properties, including bioactivity, biodegradability, and monodispersity. Herein, we report the development of a copolymeric hydrogel that is based on the calcium-dependent protein, calmodulin (CaM). Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00043DOI Listing

Bottlebrush Glycopolymers from 2-Oxazolines and Acrylamides for Targeting Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin and Mannose-Binding Lectin.

Biomacromolecules 2020 Apr 30. Epub 2020 Apr 30.

Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.

Lectins are omnipresent carbohydrate binding proteins that are involved in a multitude of biological processes. Unearthing their binding properties is a powerful tool toward the understanding and modification of their functions in biological applications. Herein, we present the synthesis of glycopolymers with a brush architecture via a "grafting from" methodology. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00246DOI Listing

Virus-Like Particles (VLPs) as a Platform for Hierarchical Compartmentalization.

Biomacromolecules 2020 May 5. Epub 2020 May 5.

Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.

Hierarchically self-assembled structures are common in biology, but it is often challenging to design and fabricate synthetic analogs. The archetypal cell is defined by hierarchically organized multicompartmentalized structures with boundaries that delineate the interior from exterior environments and is an inspiration for complex functional materials. Here, we have demonstrated an approach to the design and construction of a nested protein cage system that can additionally incorporate the packing of other functional macromolecules and exhibit some of the features of a minimal synthetic cell-like material. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00030DOI Listing

Synthesis and Hydration Behavior of a Hydrolysis-Resistant Quasi-Choline Phosphate Zwitterionic Polymer.

Biomacromolecules 2020 Apr 30. Epub 2020 Apr 30.

Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

A hydrolysis-resistant polymer bearing new quasi-choline phosphate (quasi-CP) structures as side groups, poly(2-methacryloyloxyethyl choline methylphosphonate) (), was designed and synthesized. Radical polymerization and sub-surface-initiated radical polymerization were used to prepare homopolymer and polymer brush on polymer substrates. Hydrolytic stability and hydrophilicity of the polymer were confirmed by nuclear magnetic resonance and contact angle measurements. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00120DOI Listing

Injectable and Self-Healing Nanocomposite Hydrogels with Ultrasensitive pH-Responsiveness and Tunable Mechanical Properties: Implications for Controlled Drug Delivery.

Biomacromolecules 2020 Apr 29. Epub 2020 Apr 29.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.

Injectable, self-healing, and pH-responsive hydrogels are great intelligent drug delivery systems for controlled and localized therapeutic release. Hydrogels that show pH-sensitive behaviors in the mildly acidic range are ideal to be used for the treatment of regions showing local acidosis like tumors, wounds and infections. In this work, we present a facile preparation of an injectable, self-healing, and supersensitive pH-responsive nanocomposite hydrogel based on Schiff base reactions between aldehyde-functionalized polymers and amine-modified silica nanoparticles. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00347DOI Listing
April 2020
5.750 Impact Factor

Polymorphism and Multiple Melting Behavior of Bio-Based Poly(propylene 2,5-furandicarboxylate).

Biomacromolecules 2020 Apr 28. Epub 2020 Apr 28.

Interdisciplinary Center for Transfer-oriented Research in Natural Sciences, Martin Luther University Halle-Wittenberg, 06099 Halle/Saale, Germany.

Furandicarboxylate-based polyesters are considered an interesting class of bio-based polymers due to their improved properties with respect to the petrol-based terephthalate homologs. An in-depth analysis of the crystal structure of poly(propylene 2,5-furandicarboxylate) (PPF), after maximum possible removal of the catalyst, was carried out. The study disclosed that purified PPF presents two different crystalline phases after crystallization from the melt. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00039DOI Listing

Impact of the Combined Use of Magnetite Nanoparticles and Cellulose Nanocrystals on the Shape-Memory Behavior of Hybrid Polyurethane Bionanocomposites.

Biomacromolecules 2020 Apr 23. Epub 2020 Apr 23.

Group 'Materials + Technologies', Department of Chemical and Environmental Engineering, Faculty of Engineering of Gipuzkoa, University of the Basque Country, Pza Europa 1, Donostia-San Sebastian 20018, Spain.

Hybrid bionanocomposites with shape-memory behavior are reported. The materials were accessed by combining a polyurethane matrix with a highly renewable carbon content, cellulose nanocrystals (CNCs), and magnetite nanoparticles (MNPs). The integration of the two nanoparticle types resulted in tough materials that display a higher stiffness and storage modulus in the glassy and rubbery state, thus contributing to the structural reinforcement, as well as magnetic properties, reflecting a synergistic effect of this combination. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b01764DOI Listing

Highly Mineralized Biomimetic Polysaccharide Nanofiber Materials Using Enzymatic Mineralization.

Biomacromolecules 2020 Apr 22. Epub 2020 Apr 22.

A3BMS Lab-Active, Adaptive and Autonomous Bioinspired Materials, Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Straße 31, 79104 Freiburg, Germany.

Many biological high-performance composites, such as bone, antler, and crustacean cuticles, are composed of densely mineralized and ordered nanofiber materials. The mimicry of even simplistic bioinspired structures, i.e. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00160DOI Listing

Caspofungin Functionalized Polymethacrylates with Antifungal Properties.

Biomacromolecules 2020 May 13. Epub 2020 May 13.

Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany.

We describe the synthesis of hydrophilic poly(poly(ethylene glycol) methyl ether methacrylate) (PmPEGMA) and hydrophobic poly(methyl methacrylate) (PMMA) caspofungin conjugates by a post-polymerization modification of copolymers containing 10 mol % pentafluorophenyl methacrylate (PFPMA), which were obtained via reversible addition-fragmentation chain transfer copolymerization. The coupling of the clinically used antifungal caspofungin was confirmed and quantified in detail by a combination of H-, F- and diffusion-ordered NMR spectroscopy, UV-vis spectroscopy, and size exclusion chromatography. The trifunctional amine-containing antifungal was attached via several amide bonds to the hydrophobic PMMA, but sterical hindrance induced by the mPEGMA side chains prohibited intramolecular double functionalization. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00096DOI Listing

Poly(ethyl acrylate--methyl Methacrylate--trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for L. Seeds Oil: a Versatile Antidiabetic Agent.

Biomacromolecules 2020 Apr 28. Epub 2020 Apr 28.

Univ Lyon, Université Claude Bernard Lyon-1, CNRS, LAGEPP UMR 5007, F-69622 Lyon, France.

Food waste valorization practices have gained considerable attention focusing on the conversion of the waste into valuable products. In this context, the present study provides an insight into a new Eudragit RS100 based nanosystem as a carrier of date palm ( L.) seeds oil known for its an antidiabetic activity. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00255DOI Listing

Smart Glycopolymeric Nanoparticles for Multivalent Lectin Binding and Stimuli-Controlled Guest Release.

Biomacromolecules 2020 Apr 10. Epub 2020 Apr 10.

Organic Chemistry and Cenide, University of Duisburg-Essen, Universitätsstrasse 7, D-45117 Essen, Germany.

The synthesis and self-assembly of a polymer featuring a self-complementary supramolecular binding motif guanidiniocarbonyl pyrrole carboxylate zwitterion (GCP-zwitterion) bearing lactose moieties are reported. The GCP-zwitterion acts as a cross-linker to facilitate self-assembly of the polymeric chain into nanoparticles (NPs) at neutral pH in an aqueous medium. The formation of polymeric NPs can be controlled by addition of external stimuli (acid or base), which disfavors self-assembly of the GCP-zwitterion because of protonation or deprotonation of the GCP units in the polymer chain. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00292DOI Listing

Inverse Electron-Demand Diels-Alder Methylcellulose Hydrogels Enable the Co-delivery of Chondroitinase ABC and Neural Progenitor Cells.

Biomacromolecules 2020 Apr 22. Epub 2020 Apr 22.

Department of Chemical Engineering & Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada.

A hydrogel that can deliver both proteins and cells enables the local microenvironment of transplanted cells to be manipulated with a single injection. Toward this goal, we designed a hydrogel suitable for the co-delivery of neural stem cells and chondroitinase ABC (ChABC), a potent enzyme that degrades the glial scar that forms after central nervous system (CNS) injury. We leveraged the inverse electron-demand Diels-Alder reaction between norbornene and methylphenyltetrazine to form rapidly gelling (<15 min) crosslinked methylcellulose (MC) hydrogels at physiological temperature and pH, with Young's modulus similar to that of brain tissue (1-3 kPa), and degradable, disulfide-containing crosslinkers. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00357DOI Listing
April 2020
5.750 Impact Factor

Role of Sheet-Edge Interactions in β-sheet Self-Assembling Peptide Hydrogels.

Biomacromolecules 2020 Apr 23. Epub 2020 Apr 23.

School of Materials, The University of Manchester, Oxford Road, M13 9PL Manchester, U.K.

Hydrogels' hydrated fibrillar nature makes them the material of choice for the design and engineering of 3D scaffolds for cell culture, tissue engineering, and drug-delivery applications. One particular class of hydrogels which has been the focus of significant research is self-assembling peptide hydrogels. In the present work, we were interested in exploring how fiber-fiber edge interactions affect the self-assembly and gelation properties of amphipathic peptides. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00229DOI Listing

Changes to the Contour Length, Molecular Chain Length, and Solid-State Structures of Nanocellulose Resulting from Sonication in Water.

Biomacromolecules 2020 Apr 16. Epub 2020 Apr 16.

Department of Biomaterials Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

Sonication in water reduced the average contour lengths of nanocellulose prepared from wood cellulose fiber and microcrystalline cellulose. Most of the kinks in the wood cellulose nanofibrils were formed during the initial 10 min of sonication. Fragmentation occurred at the kinks and rigid segments associated with depolymerization during subsequent sonication for 10-120 min, resulting in the formation of cellulose nanocrystals with low aspect ratios. Read More

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http://dx.doi.org/10.1021/acs.biomac.0c00281DOI Listing