7,463 results match your criteria Biomacromolecules [Journal]


Enhancement of self-aggregation properties of linear elastin-derived short peptides by simple cyclization: strong self-aggregation properties of cyclo[FPGVG], consisting only of natural amino acids.

Biomacromolecules 2018 Jun 22. Epub 2018 Jun 22.

Elastin-like peptides (ELP) consist of distinctive repetitive sequences, such as (VPGVG), exhibit temperature-dependent reversible self-assembly (coacervation), and have been considered to be useful for the development of thermo-responsive materials. Further fundamental studies evaluating coacervative properties of novel nonlinear ELPs could present design concepts for new thermo-responsive materials. In this study, we prepared novel ELPs, cyclic (FPGVG) (cyclo[FPGVG], n = 1-5), and analyzed its self-assembly properties and structural characteristics. Read More

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Genetically engineered mucoadhesive spider silk.

Biomacromolecules 2018 Jun 22. Epub 2018 Jun 22.

Mucoadhesion is defined as the adhesion of a material to the mucus gel covering the mucous membranes. The mechanisms controlling mucoadhesion include nonspecific electrostatic interactions and specific interactions between the materials and the mucins, the heavily glycosylated proteins that form the mucus gel. Mucoadhesive materials can be used to develop mucosal wound dressings, and noninvasive transmucosal drug delivery systems. Read More

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Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Micro-organisms.

Biomacromolecules 2018 Jun 22. Epub 2018 Jun 22.

All modern molecular biology and microbiology is underpinned not only by the tools to handle and manipulate microorganisms, but also those to store, bank and transport them. Glycerol is the current gold-standard cryoprotectant but it is intrinsically toxic to most micro-organisms: only a fraction of cells survive freezing and the presence of glycerol can impact down-stream applications and assays. Extremophile organisms survive repeated freeze/thaw cycles by producing antifreeze proteins which are potent ice recrystallization inhibitors. Read More

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Enhanced differentiation potential of primary human endometrial cells cultured on 3D scaffolds.

Biomacromolecules 2018 Jun 21. Epub 2018 Jun 21.

Novel approaches for culturing primary human cells in vitro are increasingly needed to study cell and tissue physiology and to grow replacement tissue for regenerative medicine. Conventional 2D monolayer cultures of endometrial epithelial and stromal cells fail to replicate the complex 3D architecture of tissue. A fully synthetic scaffold that mimics the microenvironment of the human endometrium can ultimately provide a robust platform for investigating tissue physiology and, hence, take significant steps towards tackling female infertility and IVF failure. Read More

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Radical Scavenging Activities of Biomimetic Catechol-Chitosan Films.

Biomacromolecules 2018 Jun 21. Epub 2018 Jun 21.

Recent studies showed that melanin-mimetic catechol-chitosan films are redox-active and their ability to exchange electrons confers pro-oxidant activities for the sustained, in situ generation of reactive oxygen species for antimicrobial bandages. Here we electrofabricated catechol-chitosan films, demonstrate these films are redox-active, and show their ability to exchange electrons confers sustained radical scavenging activities that could be useful for protective coatings. Electrofabrication was performed in two steps: cathodic electrodeposition of a chitosan film followed by anodic grafting of catechol to chitosan. Read More

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June 2018
1 Read

pH Responsive, Functionalizable Spyrocyclic Polycarbonate: A Versatile Platform for Biocompatible Nanoparticles.

Biomacromolecules 2018 Jun 21. Epub 2018 Jun 21.

Polymeric nanoparticles are widely investigated to enhance the selectivity of therapeutics to targeted sites, as well as to increase circulation lifetime and water solubility of poorly soluble drugs. In contrast to the encapsulation of the cargo into the nanostructures, which traditionally requires the use of complex synthetic approaches or time-consuming self-assembly methods, the conjugation directly to the polymer backbone allows better control on the loading and selective triggered release. In this work we report a simple procedure to create biodegradable polycarbonate graft copolymer nanoparticles via a ring opening polymerization and subsequent post-polymerization modification strategies. Read More

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Renewable polyglobalide-based porous networks containing poly(ethylene glycol) structures prepared by photoinitiated thiol-ene coupling.

Biomacromolecules 2018 Jun 19. Epub 2018 Jun 19.

The high interest in polymers from natural resources prompted us to investigate the use of enzymatically synthesized polyglobalide (PGL) in the preparation of polymer networks with potential applications as biomaterials for drug delivery devices. Polymer networks were obtained under mild conditions by photoinitiated thiol-ene coupling between PGL and a poly(ethylene glycol-co-thiomalate) (PEG-SH) copolymer obtained by polycondensation. The obtained polymer networks were thoroughly characterized by Raman spectroscopy, scanning electron microscopy, titration of thiol groups and elemental analysis. Read More

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Enhanced Rotator-cuff Repair Using Platelet-Rich Plasma Adsorbed on Branched Poly(ester urea)s.

Biomacromolecules 2018 Jun 15. Epub 2018 Jun 15.

Platelet-rich plasma (PRP) is a clinically relevant source of growth factors used commonly by surgeons. The clinical efficacy of PRP use as reported in the literature is widely variable which is likely attributed to poorly defined retention time of PRP at the repair site. To overcome this limitation, branched poly(ester urea) (PEU) nanofibers were used to adsorb and retain PRP at the implant site in an acute rotator-cuff tear model in rats. Read More

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Biotin-Tagged Polysaccharide Vesicular Nanocarriers for Receptor-Mediated Anticancer Drug Delivery in Cancer Cells.

Biomacromolecules 2018 Jun 15. Epub 2018 Jun 15.

Biotin-conjugated multi-stimuli-responsive polysaccharide vesicular nanocarriers are designed and developed, for the first time, to accomplish receptor-mediated endocytosis in cancer cells and to deliver anticancer drugs at the intracellular compartments. For this purpose, a new renewable hydrophobic unit was custom designed with redox-degradable disulphide and enzyme-biodegradable aliphatic ester chemical linkages and it was conjugated along with biotin on the dextran backbone. The dextran derivative self-assembled into nanovesicles of < 200 nm in size which were characterized by dynamic and static light scattering, electron and atomic force microscopes. Read More

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June 2018
4 Reads

Singlet Oxygen Production and Tunable Optical Properties of Deacetylated Chitin-Porphyrin Cross-Linked Films.

Biomacromolecules 2018 Jun 14. Epub 2018 Jun 14.

The increasing need for biocompatible materials as supports to immobilize photosensitizer molecules for photodynamic therapy (PDT), led us to investigate the use of chitin as a support for 4,4',4'',4'''-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid) (mTCPP) for singlet oxygen production. Chitin was first extracted from shrimp shells using the ionic liquid 1-ethyl-3-methyl-imidazolium acetate ([Cmim][OAc]), coagulated as a floc into water, and then deacetylated to varying degrees of deacetylation using 4 M NaOH. The deacetylated chitin (DA-chitin) was dissolved in [Cmim][OAc] and mTCPP was covalently attached by reaction between the amino groups of DA-chitin and the carboxyl groups of mTCPP using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) as activators. Read More

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June 2018
2 Reads

Role of hygroscopic low molecular mass compounds in humidity responsive adhesion of spider's capture silk.

Biomacromolecules 2018 Jun 13. Epub 2018 Jun 13.

The aggregate glue in spider webs is composed of hygroscopic low molecular mass compounds (LMMCs), glycoproteins and water. The LMMCs absorb atmospheric water and solvate the glycoproteins to spread and adhere to flying insects upon contact. The glue viscosity varies with humidity and there is an optimum range of viscosity where the adhesion is maximum. Read More

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June 2018
1 Read

Isosorbide as core component for tailoring biobased unsaturated polyester thermosets for a wide structure-property window.

Biomacromolecules 2018 Jun 13. Epub 2018 Jun 13.

Biobased unsaturated polyester thermosets as potential replacements for petroleum-based thermosets were designed. The target of incorporating rigid units, to yield thermosets with high thermal and mechanical performance, both in the biobased unsaturated polyester (UP) and reactive diluent (RD) while retaining miscibility was successfully achieved. The biobased unsaturated polyester thermosets were prepared by varying the content of isosorbide, 1,4-butanediol, maleic anhydride and succinic anhydride in combination with the reactive diluent isosorbide-methacrylate (IM). Read More

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June 2018
2 Reads

Multilayered Controlled Drug Release Silk Fibroin Nanofilm by Manipulating Secondary Structure.

Biomacromolecules 2018 Jun 22. Epub 2018 Jun 22.

Department of Chemical & Biomolecular Engineering, College of Engineering , Yonsei University , 50 Yonsei-ro, Seodaemun-gu , Seoul 03722 , Republic of Korea.

Many studies of drug delivery nanoplatforms have explored drug loading affinity and controlled release. The nanoplatforms can be influenced by their inherent building blocks. Natural polypeptide silk fibroin (SF) is an excellent nanoplatform material because of its high biocompatibility and unique structural properties. Read More

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June 2018
1 Read

Glycan-Directed Grafting-from Polymerization of Immunoglobulin G: Site-Selectively Modified IgG-Polymer Conjugates with Preserved Biological Activity.

Biomacromolecules 2018 Jun 21. Epub 2018 Jun 21.

Department of Chemistry , National Sun Yat-sen University 70, Lienhai Road , Kaohsiung 80424 , Taiwan.

Antibody and related antibody drugs for the treatment of malignancies have led to progress in targeted cancer therapy. Preparation of diverse antibody conjugates is critical for preclinical and clinical applications. However, precise control in tagging molecules at specific locations on antibodies is essential to preserve their native function. Read More

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June 2018
1 Read

Investigating the Cell-Uptake of Guanidinium-Rich RAFT Polymers: Impact of Comonomer and Monomer Distribution.

Biomacromolecules 2018 Jun 11. Epub 2018 Jun 11.

A range of well-defined guanidinium-rich linear polymers with demonstrable efficiency for cellular internalisation were developed. A protected guanidinium-functional acrylamide monomer (di-Boc-guanidinium ethyl acrylamide, GEAdiBoc) was synthesised and then polymerised via RAFT polymerisation to yield well-defined homopolymers, which were then deprotected and functionalised with a fluorescein dye to observe and quantify their cellular uptake. The cellular uptake of these homopolymers was first compared to polyArginine analogues, which are commonly used in modern drug delivery. Read More

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June 2018
3 Reads

Chitin nanoforms provide mechanical and topological cues to support growth of human adipose stem cells in chitosan matrices.

Biomacromolecules 2018 Jun 11. Epub 2018 Jun 11.

The precise role and value of incorporating nanoforms in biologically active matrices for medical applications is not known. In our current work, we incorporate two chitin nanoforms (i.e. Read More

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June 2018
2 Reads

Polymers from Nature and for Nature.

Biomacromolecules 2018 Jun;19(6):1697-1700

Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science , Soochow University , Suzhou , 215123 , P. R. China.

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June 2018
1 Read

Importance of Encapsulation Stability of Nanocarriers with High Drug Loading Capacity for Increasing in Vivo Therapeutic Efficacy.

Biomacromolecules 2018 Jun 22. Epub 2018 Jun 22.

Current drug delivery systems are hampered by poor delivery to tumors, in part reflecting poor encapsulation stability of nanocarriers. Although nanocarriers such as polymeric micelles have high colloidal stability and do not aggregate or precipitate in bulk solution, nanocarriers with low encapsulation stability can lose their cargo during circulation in blood due to interactions with blood cells, cellular membranes, serum proteins, and other biomacromolecules. The resulting premature drug release from carriers limits the therapeutic efficacy at target sites. Read More

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June 2018
3 Reads

Tumor-pH-Sensitive PLLA-Based Microsphere with Acid Cleavable Acetal Bonds on the Backbone for Efficient Localized Chemotherapy.

Biomacromolecules 2018 Jun 21. Epub 2018 Jun 21.

National Engineering Research Center for Biomaterials , Sichuan University , Chengdu 610064 , China.

Nanoparticle- and microsphere-based drug delivery systems (DDSs) have attracted wide attention in cancer therapy; those DDSs that are responsive to tumor environment can selectively identify tumor and normal tissues and therefore have shown enhanced anticancer efficacy and alleviated systemic toxicity. Here, tumor-pH-sensitive polymeric microspheres, which are prepared by multiblock poly(l-lactide) with pH-sensitive acetal bonds in the backbone, are employed to efficiently load water-soluble anticancer drug doxorubicin hydrochloride (DOX·HCl, drug loading content: ∼10%). The pH-sensitive DOX-loaded hollow microspheres were in the size range 2-10 μm and exhibited acid-accelerated degradation of polymer matrix and drug release, and thereby efficient in vitro cancer cell inhibition. Read More

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June 2018
3 Reads

Chemoenzymatic Preparation of Amylose-Grafted Chitin Nanofiber Network Materials.

Biomacromolecules 2018 Jun 18. Epub 2018 Jun 18.

Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering , Kagoshima University , 1-21-40 Korimoto , Kagoshima 890-0065 , Japan.

We previously found that the methanol-treatment of a chitin ion gel with an ionic liquid, 1-allyl-3-methylimidazolium bromide, for regeneration and subsequent filtration of a resulting self-assembled chitin nanofiber (CNF) dispersion gave a CNF film. In this study, we investigated a chemoenzymatic approach including enzymatic polymerization catalyzed by phosphorylase for the preparation of amylose-grafted CNF network materials. Maltoheptaose (Glc) as the primer for the enzymatic polymerization was immobilized on the CNF film by reductive amination with amino groups, generated by the partial deacetylation of chitin molecules. Read More

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June 2018
2 Reads

Single-Chain Glycopolymer Folding via Host-Guest Interactions and Its Unprecedented Effect on DC-SIGN Binding.

Biomacromolecules 2018 Jun 19. Epub 2018 Jun 19.

Polymer Chemistry Laboratory, School of Engineering and Materials Science, Queen Mary , University of London , E1 4NS , London , United Kingdom.

Reversible self-folding actions of natural biomacromolecules play crucial roles for specific and unique biological functions in Nature. Hence, controlled folding of single polymer chains has attracted significant attention in recent years. Herein, reversible single-chain folded glycopolymer structures in α-shape with different density of sugar moieties in the knot were created. Read More

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June 2018
2 Reads

Biocompatible Unimolecular Micelles Obtained via the Passerini Reaction as Versatile Nanocarriers for Potential Medical Applications.

Biomacromolecules 2018 Jun 15. Epub 2018 Jun 15.

Institute of Organic Chemistry (IOC), Materialwissenschaftliches Zentrum (MZE) , Karlsruhe Institute of Technology (KIT) , Straße am Forum 7 , 76131 Karlsruhe , Germany.

A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeating units, and the side chain ends were conjugated by performing a Passerini-3CR with PEG-isocyanide and PEG-aldehyde (950 g/mol). The resulting amphiphilic star-shaped block copolymers contained thioether groups, which could be oxidized to sulfones in order to further tune the polarity of the polymer chains. Read More

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June 2018
4 Reads

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters.

Biomacromolecules 2018 Jun 22. Epub 2018 Jun 22.

Department of Industrial and Physical Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.

Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U. Read More

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June 2018
1 Read

Small Delivery Vehicles of siRNA for Enhanced Cancer Targeting.

Biomacromolecules 2018 Jun 18. Epub 2018 Jun 18.

Department of Materials Engineering, Graduate School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-8656 , Japan.

Small interfering RNA (siRNA) drugs have been considered to treat various diseases in major organs. However, siRNA drugs developed for cancer therapy are hindered from proceeding to the clinic. To date, various delivery formulations have been developed from cationic lipids, polymers, and/or inorganic nanoparticles for systemic siRNA delivery to solid tumors. Read More

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June 2018
1 Read

Effects of the Physicochemical, Colloidal, and Biological Characteristics of Different Polymer Structures between α-Poly(l-lysine) and ε-Poly(l-lysine) on Polymeric Gene Delivery.

Biomacromolecules 2018 Jun 13. Epub 2018 Jun 13.

Department of Pharmacy, College of Pharmacy , The Catholic University of Korea , 43 Jibong-ro , Wonmi-gu, Bucheon-si , Gyeonggi-do 14662 , Republic of Korea.

Though α-poly(l-lysine) (APL) has been well-studied in gene delivery, ε-poly(l-lysine) (EPL) with same repeating unit of l-lysine but different structure has been rarely investigated. This study compared various effects of their different structures in gene delivery processes. EPL showed less cytotoxicity and more proton buffering capacity for endosomal release than APL. Read More

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June 2018
4 Reads

Photoresponsive micelle-incorporated doxorubicin for chemo-photodynamic therapy to achieve synergistic antitumor effects.

Biomacromolecules 2018 Jun 4. Epub 2018 Jun 4.

A combination of chemo-photodynamic therapy has been manifested as a promising strategy for efficient cancer treatment due to the enhanced therapeutic efficacy. Here, we designed doxorubicin (DOX)-loaded photoresponsive micelles (DPRMs) based on a combination of chlorin e6 (Ce6) and lipoic acid (LA) conjugated methoxy-poly(ethylene) glycol (mPEG-Ce6, mPEG-LA) to achieve effective drug delivery using a single system. DPRMs were optimized with different molar ratios of mPEG-Ce6 and mPEG-LA which showed uniformly spherical morphology of size ~130 nm and approximately 9% of DOX loading contents. Read More

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June 2018
1 Read

Photoswitching of Cell Penetration of Amphipathic Peptides by Control of α-Helical Conformation.

Biomacromolecules 2018 Jun 8. Epub 2018 Jun 8.

We stapled an amphipathic peptide mainly consisting of leucine (L) and lysine (K) by an azobenzene (Ab) linker for photocontrol of the secondary structure. The cis- trans isomerization of the Ab moieties could stabilize and destabilize the α-helical conformation of the LK peptide along with dramatic change of associated peptide structures in a reversible manner by UV-vis irradiation. The cell-penetrating activities of the LK peptide can be readily regulated by the photocontrol, as the stabilized cis-Ab-LK peptide showed remarkable increase of cell penetration compared to the destabilized trans-Ab-LK peptide. Read More

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June 2018
2 Reads

Cell-Penetrating Peptide-Patchy Deformable Polymeric Nanovehicles with Enhanced Cellular Uptake and Transdermal Delivery.

Biomacromolecules 2018 Jun 8. Epub 2018 Jun 8.

Department of Bionano Technology , Hanyang University , Ansan 15588 , Republic of Korea.

We herein propose a polymeric nanovehicle system that has the ability to remarkably improve cellular uptake and transdermal delivery. Cell-penetrating peptide-patchy deformable polymeric nanovehicles were fabricated by tailored coassembly of amphiphilic poly(ethylene oxide)- block-poly(ε-caprolactone) (PEO- b-PCL), mannosylerythritol lipid (MEL), and YGRKKRRQRRR-cysteamine (TAT)-linked MEL. Using X-ray diffraction, differential scanning calorimetry, and nuclear magnetic resonance analyses, we revealed that the incorporation of MEL having an asymmetric alkyl chain configuration was responsible for the deformable phase property of the vehicles. Read More

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June 2018
2 Reads

Engineering Tunable Dual Functional Protein Cage Nanoparticles Using Bacterial Superglue.

Biomacromolecules 2018 May 30. Epub 2018 May 30.

Department of Biological Sciences, School of Life Sciences , Ulsan National Institute of Science and Technology (UNIST) , Ulsan , 44919 , Korea.

The selective detection of specific cells of interest and their effective visualization is important but challenging, and fluorescent cell imaging with target-specific probes is commonly used to visualize cell morphology and components and to track cellular processes. Multiple displays of two or more targeting ligands on a polyvalent single template would make it possible to construct versatile multiplex fluorescent cell imaging probes that can visualize two or more target cells individually without the need for a set of individual probes. To achieve this goal, we used encapsulin, a new class of protein cage nanoparticles, as a template and implanted dual targeting capability by presenting two different affibody molecules on a single encapsulin protein cage nanoparticle post-translationally. Read More

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May 2018
1 Read

Nanomechanics of Pectin-Linked β-Lactoglobulin Nanofibril Bundles.

Biomacromolecules 2018 Jun 14. Epub 2018 Jun 14.

Quadram Institute Bioscience , Norwich Research Park, Norwich , Norfolk NR4 7UA , U.K.

Nanofibrils of β-lactoglobulin can be assembled into bundles by site-specific noncovalent cross-linking with high-methoxyl pectin (Hettiarachchi et al. Soft Matter 2016, 12, 756). Here we characterized the nanomechanical properties of bundles using atomic force microscopy and force spectroscopy. Read More

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June 2018
2 Reads

Galactose Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma.

Biomacromolecules 2018 Jun 29;19(6):2330-2339. Epub 2018 May 29.

Department of Chemistry , National Tsing Hua University , Hsinchu 30013 , Taiwan.

Successful siRNA therapy requires suitable delivery systems with targeting moieties such as small molecules, peptides, antibodies, or aptamers. Galactose (Gal) residues recognized by the asialoglycoprotein receptor (ASGPR) can serve as potent targeting moieties for hepatocellular carcinoma (HCC) cells. However, efficient targeting to HCC via galactose moieties rather than normal liver tissues in HCC patients remains a challenge. Read More

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June 2018
1 Read

The Power of Shielding: Low Toxicity and High Transfection Performance of Cationic Graft Copolymers Containing Poly(2-oxazoline) Side Chains.

Biomacromolecules 2018 Jun 12. Epub 2018 Jun 12.

Laboratory of Organic and Macromolecular Chemistry (IOMC) , Friedrich Schiller University Jena , Humboldtstrasse 10 , 07743 Jena , Germany.

We show the potential of oligo(2-ethyl-2-oxazoline) (Ox)-shielded graft copolymers of (2-aminoethyl)-methacrylate and N-methyl-(2-aminoethyl)-methacrylate for pDNA delivery in HEK cells. For the effect of grafting density and side chain length concerning improved transfection properties through the concept of shielding to be investigated, copolymers were synthesized via the macromonomer method using a combination of cationic ring opening polymerization and reversible addition-fragmentation chain transfer polymerization to vary the degree of grafting (DG = 10 and 30%) as well as the side chain degree of polymerization (DP = 5 and 20). Investigations of the polyplex formation, in vitro flow cytometry, and confocal laser scanning microscopy measurements on the copolymer library revealed classical shielding properties of the Ox side chains, including highly reduced cytotoxicity and a partial decrease in transfection efficiency, as also reported for polyethylene glycol shielding. Read More

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June 2018
4 Reads

Recent Advances and Progress on Melanin-like Materials and Their Biomedical Applications.

Biomacromolecules 2018 Jun 23;19(6):1858-1868. Epub 2018 May 23.

Department of Chemistry and the Tsinghua Center for Frontier Polymer Research , Tsinghua University , Beijing 100084 , P.R. China.

Melanins are well-known biopolymers that are ubiquitous in nature, distributed widely in microorganisms, plants, and animals, and play significant physiological roles. They are mostly biopolymers formed from phenolic compounds by polymerization via quinones. Poly(dopamine) (PDA), a melanin-like material, is similar in structure and properties to eumelanin and has attracted considerable interest for various types of biological applications. Read More

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June 2018
2 Reads

Elastin-like Polypeptide (ELP) Charge Influences Self-Assembly of ELP-mCherry Fusion Proteins.

Biomacromolecules 2018 May 23. Epub 2018 May 23.

Department of Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

Self-assembly of protein-polymer bioconjugates presents an elegant strategy for controlling nanostructure and orientation of globular proteins in functional materials. Recent work has shown that genetic fusion of globular protein mCherry to an elastin-like polypeptide (ELP) yields similar self-assembly behavior to these protein-polymer bioconjugates. In the context of studying protein-polymer bioconjugate self-assembly, the mutability of the ELP sequence allows several different properties of the ELP block to be tuned orthogonally while maintaining consistent polypeptide backbone chemistry. Read More

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May 2018
5 Reads

Synthesis of a Pillar[5]arene-Based Polyrotaxane for Enhancing the Drug Loading Capacity of PCL-Based Supramolecular Amphiphile as an Excellent Drug Delivery Platform.

Biomacromolecules 2018 May 30. Epub 2018 May 30.

Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering , East China University of Science and Technology , Shanghai 200237 , China.

A pillar[5]arene-based nonionic polyrotaxane (PR) with star-poly(ε-caprolactone) ( S-PCL) as the axle, pillar[5]arene (DEP5) as the wheel and adamantane as the end-capped group is designed and synthesized. The resulting PR is subsequently assembled with β-cyclodextrin end-capped pH-stimulated poly(acrylic acid) (CD-PAA) via a host-guest interaction to form the supramolecular pseudoblock polymer PR-PAA. This supramolecular pseudoblock polymer could self-assemble in aqueous solution to produce PR-PAA-based supramolecular vesicular nanoparticles (PR-SVNPs), which present significantly enhanced drug loading capacity (DLC, 45. Read More

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May 2018
4 Reads

Recent Advances in Biodegradable Conducting Polymers and Their Biomedical Applications.

Authors:
Kenry Bin Liu

Biomacromolecules 2018 Jun 22;19(6):1783-1803. Epub 2018 May 22.

Department of Chemical and Biomolecular Engineering , National University of Singapore , 4 Engineering Drive 4 , 117585 Singapore.

The growing importance of biodegradable conducting polymers (CPs) have fueled the rapid development of this unique class of polymeric materials in recent years. Possessing both the electrical conductivity approaching those of metallic conductors and the biodegradability of biocompatible polymers, biodegradable CPs are highly sought after. In fact, they have emerged as the ideal biomaterials, having immense potential for augmenting a wide range of practical biomedical applications. Read More

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June 2018
2 Reads

Zinc(II)-Histidine Induced Collagen Peptide Assemblies: Morphology Modulation and Hydrolytic Catalysis Evaluation.

Biomacromolecules 2018 May 30. Epub 2018 May 30.

Collagen-related materials have many potential biomedical applications because of their high biocompatibility and biodegradability. Designed collagen-mimetic peptides (CMPs) could self-assemble into supramolecular structures via a variety of interactions. In particular, metal-ligand interactions can induce microscale sizes of collagen assemblies. Read More

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May 2018
4 Reads

Synergistic Enhancement of Enzyme Performance and Resilience via Orthogonal Peptide-Protein Chemistry Enabled Multilayer Construction.

Biomacromolecules 2018 Jun 15. Epub 2018 Jun 15.

Key Laboratory of Polymer Chemistry & Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , P. R. China.

Protein immobilization is critical to utilize their unique functions in diverse applications. Herein, we report that orthogonal peptide-protein chemistry enabled multilayer construction can facilitate the incorporation of various folded structural domains, including calmodulin in different states, affibody, and dihydrofolate reductase (DHFR). An extended conformation is found to be the most advantageous for steady film growth. Read More

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June 2018
2 Reads

Tuned Density of Anti-Tissue Factor Antibody Fragment onto siRNA-Loaded Polyion Complex Micelles for Optimizing Targetability into Pancreatic Cancer Cells.

Biomacromolecules 2018 Jun 22;19(6):2320-2329. Epub 2018 May 22.

Innovation Center of Nanomedicine , Kawasaki Institute of Industrial Promotion , 3-25-14 Tonomachi , Kawasaki-ku , Kawasaki 210-0821 , Japan.

Antibody fragment (Fab')-installed polyion complex (PIC) micelles were constructed to improve targetability of small interfering RNA (siRNA) delivery to pancreatic cancer cells. To this end, we synthesized a block copolymer of azide-functionalized poly(ethylene glycol) and poly(l-lysine) and prepared PIC micelles with siRNA. Then, a dibenzylcyclooctyne (DBCO)-modified antihuman tissue factor (TF) Fab' was conjugated to azido groups on the micellar surface. Read More

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June 2018
9 Reads

Redox-Responsive Micellar Nanoparticles from Glycosaminoglycans for CD44 Targeted Drug Delivery.

Biomacromolecules 2018 May 23. Epub 2018 May 23.

Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics , University of Minho , Avepark, 4805-017 Barco, Guimarães , Portugal.

Cancer progression is associated with overexpression of various receptors at the cell surface. Among these, CD44 is known to recognize and bind specifically hyaluronan (HA) and interact with less affinity to other glycosaminoglycans (GAGs), such as chondroitin sulfate (CS). In this study, we describe a simple method to obtain micellar nanoparticles with a GAG shell (HA or CS) as potential drug delivery systems that target cancer cells overexpressing CD44. Read More

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May 2018
3 Reads

Transparent, Flexible, and Strong 2,3-Dialdehyde Cellulose Films with High Oxygen Barrier Properties.

Biomacromolecules 2018 May 22. Epub 2018 May 22.

Department of Food and Environmental Sciences , University of Helsinki , P.O. Box 27, Helsinki , Finland.

2,3-Dialdehyde cellulose (DAC) of a high degree of oxidation (92% relative to AGU units) prepared by oxidation of microcrystalline cellulose with sodium periodate (48 °C, 19 h) is soluble in hot water. Solution casting, slow air drying, hot pressing, and reinforcement by cellulose nanocrystals afforded films (∼100 μm thickness) that feature intriguing properties: they have very smooth surfaces (SEM), are highly flexible, and have good light transmittance for both the visible and near-infrared range (89-91%), high tensile strength (81-122 MPa), and modulus of elasticity (3.4-4. Read More

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May 2018
2 Reads

Preserving Cellulose Structure: Delignified Wood Fibers for Paper Structures of High Strength and Transparency.

Biomacromolecules 2018 May 23. Epub 2018 May 23.

Wallenberg Wood Science Center, Department of Fiber and Polymer Technology , KTH Royal Institute of Technology , SE-10044 Stockholm , Sweden.

To expand the use of renewable materials, paper products with superior mechanical and optical properties are needed. Although beating, bleaching, and additives are known to improve industrially produced Kraft pulp papers, properties are limited by the quality of the fibers. While the use of nanocellulose has been shown to significantly increase paper properties, the current cost associated with their production has limited their industrial relevance. Read More

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May 2018
1 Read

Stimuli-Sensitive and -Responsive Polymer Biomaterials.

Biomacromolecules 2018 May;19(5):1375-1377

École Polytechnique Fédérale de Lausanne (EPFL) , Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD , Station 12 , CH-1015 Lausanne , Switzerland.

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May 2018
1 Read

Effect of Anisotropy of Cellulose Nanocrystal Suspensions on Stratification, Domain Structure Formation, and Structural Colors.

Biomacromolecules 2018 May 22. Epub 2018 May 22.

Department of Chemical and Biomolecular Engineering , North Carolina State University , Raleigh , North Carolina 27695 , United States.

Outstanding optical and mechanical properties can be obtained from hierarchical assemblies of nanoparticles. Herein, the formation of helically ordered, chiral nematic films obtained from aqueous suspensions of cellulose nanocrystals (CNCs) were studied as a function of the initial suspension state. Specifically, nanoparticle organization and the structural colors displayed by the resultant dry films were investigated as a function of the anisotropic volume fraction (AVF), which depended on the initial CNC concentration and equilibration time. Read More

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May 2018
6 Reads

Luminescent Gold Nanocluster-Decorated Polymeric Hybrid Particles with Assembly-Induced Emission.

Biomacromolecules 2018 May 23. Epub 2018 May 23.

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science , Utrecht University , Universiteitsweg 99 , 3584 CG Utrecht , The Netherlands.

Ultrasmall gold atom clusters (<2 nm in diameter) or gold nanoclusters exhibit emergent photonic properties (near-infrared absorption and emission) compared to larger plasmonic gold particles because of the significant quantization of their conduction band. Although single gold nanocluster properties and applications are being increasingly investigated, little is still known about their behavior and properties when assembled into suprastructures, and even fewer studies are investigating their use for biomedical applications. Here, a simple synthetic pathway combines gold nanoclusters with thermosensitive diblock copolymers of poly(ethylene glycol) (PEG) and poly( N-isopropylacrylamide) (PNIPAm) to form a new class of gold-polymer, micelle-forming, hybrid nanoparticle. Read More

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May 2018
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Surface Modification with a Catechol-Bearing Polypeptide and Sensing Applications.

Biomacromolecules 2018 May 23. Epub 2018 May 23.

Department of Chemistry, Faculty of Science and Letters , Istanbul Technical University , 34469 Maslak, Istanbul , Turkey.

A novel catechol-bearing polypeptide (CtP) was synthesized and used as a component of electrochemical biosensor involving both enzymatic activity and affinity-based sensing systems. Glucose oxidase (GOx) and anti-immunoglobulin G (Anti-IgG) were selected as model biorecognition elements for the selective analysis of glucose and IgG. Step-by-step surface modifications were followed using various techniques such as cyclic voltammetry (CV) and electrochemical impedance spectrometry (EIS) as well as X-ray photoelectron spectroscopy (XPS). Read More

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May 2018
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Investigating the Influence of Aromatic Moieties on the Formulation of Hydrophobic Natural Products and Drugs in Poly(2-oxazoline)-Based Amphiphiles.

Biomacromolecules 2018 May 29. Epub 2018 May 29.

Functional Polymer Materials, Chair for Advanced Materials Synthesis, Department of Chemistry and Pharmacy , Julius-Maximilians-Universität Würzburg , Röntgenring 11 , 97070 Würzburg , Germany.

Many natural compounds with interesting biomedical properties share one physicochemical property, namely, low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse, and recently it has been discussed that macromolecular engineering can be used to optimize drug-loaded micelles. Read More

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May 2018
3 Reads

Fast Degradable Polycaprolactone for Drug Delivery.

Biomacromolecules 2018 Jun 15;19(6):2302-2307. Epub 2018 May 15.

Department of Chemistry and Nanoscience , Ewha Womans University , 52 Ewhayeodae-gil , Seodaemun-gu, Seoul , 03760 , Korea.

Polycaprolactone (PCL) was reported a long time ago; however, its biomedical applications has not been extensively investigated in comparison with poly(lactide- co-glycolide) (PLGA) due to its too slow degradation profile. Here, we are reporting an oxalate-connected oligocaprolactone multiblock copolymer (PCL-OX) as a fast degradable PCL while maintaining its crystalline properties and low melting point of PCL. The in vivo application of the paclitaxel-loaded PCL-OX microspheres provided a steady plasma drug concentration of 6-9 μg/mL over 28 days, similar to that of the PLGA microspheres. Read More

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June 2018
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Antiamyloidogenic Chemical/Biochemical-Based Designed Nanoparticle as Artificial Chaperone for Efficient Inhibition of Protein Aggregation.

Biomacromolecules 2018 Jun 18;19(6):1721-1731. Epub 2018 May 18.

Centre for Advanced Materials , Indian Association for the Cultivation of Science , Kolkata 700032 , India.

Protein aggregation is linked to variety of neurodegenerative disorders and other diseases. Current research involves understanding the mechanism of protein aggregation, inhibiting protein aggregation under intra/extracellular space, lowering toxicity arising due to soluble oligomers, and augmenting the clearance of protein aggregates from the brain. Toward this direction, different types of antiamyloidogenic small molecules, macromolecules, and nanomaterials are identified that can inhibit protein aggregation, and extensive progress has been made for their effective utilization. Read More

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June 2018
3 Reads