7,802 results match your criteria Biomacromolecules [Journal]


Acute B-Cell Inhibition by Soluble Antigen Arrays is Valency-Dependent and Predicts Immunomodulation in Splenocytes.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Antigen valency plays a fundamental role in directing the nature of an immune response to be stimulatory or tolerogenic. Soluble Antigen Arrays (SAgAs) are an antigen-specific immunotherapy that combats autoimmunity through the multivalent display of autoantigen. While mechanistic studies have shown SAgAs to induce T and B-cell anergy, the effect of SAgA valency has never been experimentally tested. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00328
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http://dx.doi.org/10.1021/acs.biomac.9b00328DOI Listing
April 2019
1 Read

Fibril self-assembly of amyloid-spider silk block polypeptides.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Due to their association with debilitating diseases and their potential applications in developing novel bionanomaterials, highly ordered amyloid fibrils have recently received considerable attention. While many studies have thus far focused on amyloid fibrils made with short peptides containing just one steric zipper-forming segment of native amyloid proteins, the self-assembly of proteins containing multiple steric zipper-forming segments has been rarely explored. Here we develop a strategy to create four block polypeptides, each containing 16 repeats of a zipper-forming segment from four different amyloid morphological classes. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00218DOI Listing

Fluorinated Glycopolymers as Reduction-responsive F MRI Agents for Targeted Imaging of Cancer.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Imaging agents that can be targeted to specific diseases and respond to the microenvironment of the diseased tissue are of considerable interest due to their potential in diagnosing and managing diseases. Here we report a new class of branched fluorinated glycopolymers as F MRI contrast agents which respond to a reductive environment, for targeted imaging of cancer. The fluorinated glycopolymers can be readily prepared by a one-pot RAFT polymerization of glucose- and fluorine-containing monomers in the presence of a disulfide-containing crosslinking monomer. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00241
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http://dx.doi.org/10.1021/acs.biomac.9b00241DOI Listing
April 2019
1 Read

Highly Stretchable and Compressible Cellulose Ionic Hydrogels for Flexible Strain Sensors.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Stretchable and compressible hydrogels based on natural polymers have received immense considerations for electronics. The feasibility of using pure natural polymer-based hydrogels could be improved, if their mechanical behaviors satisfy the requirements of practical applications. Herein, we report highly stretchable (tensile strain ~126%) and compressible (compression strain ~80%) cellulose ionic hydrogels (CIHs) among pure natural polymer-based hydrogels including cellulose, chitin and chitosan, via chemical crosslinking based on free radical polymerization of allyl cellulose in NaOH/urea aqueous solution. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00322
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http://dx.doi.org/10.1021/acs.biomac.9b00322DOI Listing
April 2019
1 Read

Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Poly(amidoamine) dendrimer (PAMAM) is well known for its high efficiency as a drug delivery vehicle. However, the intrinsic cytotoxicity and inherent lack of a detectable signal to facilitate tracking have impeded its practical applications. Herein, we have developed a novel label-free fluorescent and biocompatible PAMAM derivative by simple surface modification of PAMAM using acetaldehyde. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00494
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http://dx.doi.org/10.1021/acs.biomac.9b00494DOI Listing
April 2019
1 Read

One-Pot Synthesis of Poly(glycerol-co-succinic acid) Nanogels for Dermal Delivery.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Polyglycerol nanogels are three-dimensional polymeric networks with a few hundred nanometer sizes and ability to encapsulate and deliver cargos for a wide range of biomedical applications. However, time-consuming and multi-step synthetic routes as well as milligram-scale production have hindered further development of these nanomaterials. In this work, we report on a straightforward synthetic method for the production of polyglycerol nanoarchitectures. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01741
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http://dx.doi.org/10.1021/acs.biomac.8b01741DOI Listing
April 2019
4 Reads

Hypericin - apomyoglobin an enhanced photosensitizer complex for the treatment of tumor cells.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

Bioavailability of photosensitizers for cancer photodynamic therapy is often hampered by their low solubility in water. Here we overcome this issue by using the water-soluble protein apomyoglobin (apoMb) as a carrier for the photosensitizer hypericin (Hyp). The Hyp-apoMb complex is quickly uptaken by HeLa and PC3 cells, at submicromolar concentrations. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00222
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http://dx.doi.org/10.1021/acs.biomac.9b00222DOI Listing
April 2019
1 Read

Future Directions at the Frontier of Polymer Science and Biology.

Biomacromolecules 2019 Jan;20(1):1-3

Department of Chemistry and Biochemistry, and Department of Bioengineering , University of California, Los Angeles , Los Angeles , California 90095 , United States.

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01785
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http://dx.doi.org/10.1021/acs.biomac.8b01785DOI Listing
January 2019
1 Read

Molecular insights into the physical adsorption of amphiphilic protein PhaF onto copolyester surfaces.

Biomacromolecules 2019 Apr 16. Epub 2019 Apr 16.

Phasins are amphiphilic proteins located at the polymer-cytoplasm interface of bacterial polyhydroxyalkanoates (PHA). The immobilization of phasins on biomaterial surfaces is a promising way to enhance the hydrophilicity and supply cell-directing elements in bioinstructing processes. Optimizing the physical adsorption of phasins requires deep insights into molecular processes during polymer-protein interactions to preserve their structural conformation while optimizing surface coverage. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00069DOI Listing

Plasticized cellulosic films by partial esterification and welding in low-concentration ionic liquid electrolyte.

Biomacromolecules 2019 Apr 15. Epub 2019 Apr 15.

Alternatives to petroleum-based plastics are of great significance not only from the point of view of their scientific and practical impact but to reduce the environmental footprint. Inspired by the composition and structure of wood's cell walls, we used phenolic acids to endow cellulosic fibers with new properties. The fiber dissolution and homogeneous modification were performed with a recyclable ionic liquid (IL) (tetrabutylammonium acetate ([N4444][OAc]):dimethyl sulfoxide) to attain different levels of reaction activity for three phenolic acids (p-Hydroxybenzoic acid, vanillic acid, and syringic acid). Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00325DOI Listing

Biocompatible Lipopeptide-Based Antibacterial Hydrogel.

Biomacromolecules 2019 Apr 12. Epub 2019 Apr 12.

A biocompatible hydrogel containing hexa-peptide as key unit has been designed and fabricated. Our design construct comprises a β-sheet rich short hexa-peptide in the centre with a hydrophobic long chain and hydrophilic triple lysine unit attached at the N- and C- terminals respectively. Thus, it is this amphiphilic nature of the molecule that facilitates the gelation. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01836DOI Listing

Hydroxyl-Rich PGMA-Based Cationic Glycopolymers for Intracellular siRNA Delivery: Biocompatibility and Effect of Sugar Decoration Degree.

Biomacromolecules 2019 Apr 10. Epub 2019 Apr 10.

The ErbB family of proteins, structurally related to the epidermal growth factor receptor (EGFR), is found to be over-expressed in many cancers such as gliomas, lung and cervical carcinomas. Gene therapy allows to modify the expression of genes like ErbB and has been a promising strategy to target oncogenes and tumor suppressor genes. In the current work, novel hydroxyl-rich polyglycidyl methacrylate (PGMA)-based cationic glycopolymers were designed for intracellular small interfering RNA (siRNA) delivery to silence the EGFR gene. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00274DOI Listing

Impact of Elastin-like Protein Temperature Transition on PEG-ELP Hybrid Hydrogel Properties.

Biomacromolecules 2019 Apr 9. Epub 2019 Apr 9.

Biomaterial hydrogels are made by crosslinking either natural materials, which exhibit inherent bioactivity but suffer from batch-to-batch variations, or synthetic materials, which have a well-defined chemical structure but usually require chemical modification to exhibit bioactivity. Recombinant engineered proteins bridge the divide between natural and synthetic materials because proteins incorporate bioactive domains within the biopolymer backbone and have a well-defined amino acid structure and sequence. Recombinant engineered elastin-like proteins (ELPs) are modeled from the native tropoelastin sequence. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00113DOI Listing

Bulk Organocatalytic Synthetic Access to Statistical Copolyesters from L-Lactide and ε-Caprolactone Using Benzoic Acid.

Biomacromolecules 2019 Apr 9. Epub 2019 Apr 9.

The development of synthetic strategies to produce statistical copolymers based on L-lactide (L-LA) and ε-caprolactone (CL), denoted as P(LA-stat-CL), remains highly challenging in polymer chemistry. This is due to the differing reactivity of the two monomers during their ring-opening copolymerization (ROcP). Yet, P(LA-stat-CL) materials are highly sought-after as they combine the properties of both polylactide PLA and poly(ε-caprolactone) (PCL). Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00190DOI Listing

A coiled-coil affinity-based system for the controlled release of biofunctionalized gold nanoparticles from alginate hydrogels.

Biomacromolecules 2019 Apr 5. Epub 2019 Apr 5.

Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled-coil affinity pair to mediate the release of gold nanoparticles from alginate scaffolds. On the one hand, the gold nanoparticles were functionalized with Ecoil-tagged epidermal growth factor (EGF). Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00137
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http://dx.doi.org/10.1021/acs.biomac.9b00137DOI Listing
April 2019
4 Reads
5.750 Impact Factor

Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt.

Biomacromolecules 2019 Apr 17. Epub 2019 Apr 17.

BIOFORGE (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN , University of Valladolid , 47011 Valladolid , Spain.

This work investigates the physicochemical properties and in vitro accuracy of a genetically engineered drug-delivery system based on elastin-like block recombinamers. The DNA recombinant techniques allowed us to create this smart complex polymer containing bioactive sequences for internalization, lysosome activation under acidic pH, and blockage of cellular growth by a small peptide inhibitor. The recombinant polymer reversibly self-assembled when the temperature was increased above 15 °C into nanoparticles with a diameter of 72 nm and negative surface charge. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00206DOI Listing
April 2019
1 Read

Spirocyclic Acetal-Modified Dextran as a Flexible pH-Sensitive Solubility-Switching Material.

Biomacromolecules 2019 Apr 15. Epub 2019 Apr 15.

Department of Chemistry , Mount Holyoke College , South Hadley , Massachusetts 01075 , United States.

Bioresponsive polymers can enable the development of more effective drug delivery vehicles and medical materials. Acetal-modified polysaccharides allow pH-triggered solubility switching in a versatile and effective manner, but prior work has been limited to a combination of acyclic alkoxyisopropyl and cyclic isopropylidene acetals. We describe here the preparation and characterization of spirocyclic acetal-modified dextran (SpAc-Dex), which comprises dextran decorated with cyclopentyl, cyclohexyl, or cycloheptyl acetals (SpAc5-, SpAc6-, and SpAc7-Dex, respectively). Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00215DOI Listing
April 2019
2 Reads

Effect of Polymer Chain Density on Protein-Polymer Conjugate Conformation.

Biomacromolecules 2019 Apr 10. Epub 2019 Apr 10.

Institut Laue Langevin, 38042 Grenoble , France.

Many biomedical applications employ covalent attachment to synthetic polymers to enhance the efficiency of proteins or other therapeutically active molecules. We report here the impact of polymer conjugation on the structural and thermal stability of a protein model, the bovine serum albumin, using a variable number of linear biodegradable polyphosphoesters, which were covalently tethered to the protein. We observed that BSA's secondary structure measured by circular dichroism is independent of the conjugation. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00184DOI Listing
April 2019
2 Reads

Composite Films with UV-Barrier Properties Based on Bacterial Cellulose Combined with Chitosan and Poly(vinyl alcohol): Study of Puncture and Water Interaction Properties.

Biomacromolecules 2019 Apr 10. Epub 2019 Apr 10.

Instituto Politécnico Nacional , CICATA Unidad Querétaro , Cerro Blanco No. 141 , Colinas del Cimatario , Querétaro 76090 , México.

The present study describes the preparation and characterization of composite films from bacterial cellulose produced by Komagataeibacter xylinus combined with poly(vinyl alcohol) and chitosan. The unique bacterial cellulose structure provides an expanded surface area with high porosity, easing the combination with other soluble polymers by dipping. This blending method effectively reinforces the bacterial cellulose structure. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00317DOI Listing
April 2019
1 Read

Enzyme-Lignin Nanocapsules Are Sustainable Catalysts and Vehicles for the Preparation of Unique Polyvalent Bioinks.

Biomacromolecules 2019 Apr 10. Epub 2019 Apr 10.

Department of Biological and Ecological Sciences (DEB) , Tuscia University , Via S. Camillo de Lellis snc , 01100 Viterbo , Italy.

Reactive lignin nanocapsules catalyze a pigmentation reaction to furnish an innovative type of sustainable polyvalent bioink. In this nanodevice, the pigment, vehicle, binder, and additive are included in a single confined spherical space. Bioinks with different shades of color, black, gray, yellow-like, pink-like, and red/brown hues, have been prepared by selecting the reactants and the pigmentation process. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00198DOI Listing
April 2019
2 Reads

Reactive Oxygen Species (ROS)-Degradable Polymeric Nanoplatform for Hypoxia-Targeted Gene Delivery: Unpacking DNA and Reducing Toxicity.

Biomacromolecules 2019 Apr 5. Epub 2019 Apr 5.

National Engineering Research Center for Biomaterials , Sichuan University , No. 29 Wangjiang Road , Chengdu 610064 , People's Republic of China.

Smart polymers as ideal gene carriers have drawn increasing attentions due to the effective DNA release once triggered by intrinsic stimuli, as well as reduced cytotoxicity. Herein, a stimulus-responsive, positively charged and water-soluble polymer (OEI-TK ) was facilely engineered by cross-linking low molecular weight oligoethylenimine (OEI) via thioketal (TK) linkages that would cleave selectively in reactive oxygen species (ROS)-rich environments induced by hypoxia. Agarose gel electrophoresis assay demonstrated that the threshold N/P ratios for complete retardation of negatively charged DNA migration were above 5 for OEI-TK . Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00054DOI Listing
April 2019
1 Read

Recyclable Fully Biobased Chitosan Adsorbents Spray-Dried in One Pot to Microscopic Size and Enhanced Adsorption Capacity.

Biomacromolecules 2019 Apr 9. Epub 2019 Apr 9.

Department of Fibre and Polymer Technology , KTH Royal Institute of Technology , Teknikringen 58 , 10044 Stockholm , Sweden.

A facile one-pot spray-drying process was developed for fabrication and in situ crosslinking of chitosan microspheres to improve the adsorption capacity by microscopic design. A fully biobased nature was achieved by utilizing genipin (GP) as a crosslinking agent and chitosan-derived nanographene oxide (nGO) as a property tuner. The produced chitosan microspheres were further proven as powerful adsorbents for common wastewater contaminants such as anionic dyes and pharmaceutical contaminants, here modeled by methyl orange (MO) and diclofenac sodium (DCF). Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00186DOI Listing
April 2019
1 Read

Glycopolycation-DNA Polyplex Formulation N/P Ratio Affects Stability, Hemocompatibility, and in Vivo Biodistribution.

Biomacromolecules 2019 Apr 28;20(4):1530-1544. Epub 2019 Mar 28.

Center for Genome Engineering and Department of Chemistry , University of Minnesota , 207 Pleasant Street SE , Minneapolis , Minnesota 55455 , United States.

Genome editing therapies hold great promise for the cure of monogenic and other diseases; however, the application of nonviral gene delivery methods is limited by both a lack of fundamental knowledge of interactions of the gene-carrier in complex animals and biocompatibility. Herein, we characterize nonviral gene delivery vehicle formulations that are based on diblock polycations containing a hydrophilic and neutral glucose block chain extended with cationic secondary amines of three lengths, poly(methacrylamido glucopyranose- block-2-methylaminoethyl methacrylate) [P(MAG- b-MAEMt)-1, -2, -3]. These polymers were formulated with plasmid DNA to prepare polyelectrolyte complexes (polyplexes). Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01704DOI Listing

Three-Dimensional Bioprinting of Cell-Laden Constructs Using Polysaccharide-Based Self-Healing Hydrogels.

Biomacromolecules 2019 Apr 4. Epub 2019 Apr 4.

Development of biomaterial-based bioinks is critical for replacement and/or regeneration of tissues and organs by three-dimensional (3D) printing techniques. However, the number of 3D-printable biomaterials in practical use remains limited despite the rapid development of 3D printing techniques. Controlling the flow properties of bioinks and mechanical properties of the resultant printed objects is key considerations in the design of biomaterial-based bioinks for practical applications. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01589
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http://dx.doi.org/10.1021/acs.biomac.8b01589DOI Listing
April 2019
2 Reads

Protein Assemblies: Nature-Inspired and Designed Nanostructures.

Authors:
Ian W Hamley

Biomacromolecules 2019 Apr 4. Epub 2019 Apr 4.

Department of Chemistry , University of Reading , Whiteknights , Reading RG6 6AD , United Kingdom.

Ordered protein assemblies are attracting interest as next-generation biomaterials with a remarkable range of structural and functional properties, leading to potential applications in biocatalysis, materials templating, drug delivery and vaccine development. This Review covers ordered protein assemblies including protein nanowires/nanofibrils, nanorings, nanotubes, designed two- and three-dimensional ordered protein lattices and protein-like cages including polyhedral virus-like cage structures. The main focus is on designed ordered protein assemblies, in which the spatial organization of the proteins is controlled by tailored noncovalent interactions (including metal ion binding interactions, electrostatic interactions and ligand-receptor interactions among others) or by careful design of modified (mutant) proteins or de novo constructs. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00228
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http://dx.doi.org/10.1021/acs.biomac.9b00228DOI Listing
April 2019
11 Reads

Evolution of Interactions in the Protein Solution As Induced by Mono and Multivalent Ions.

Biomacromolecules 2019 Apr 1. Epub 2019 Apr 1.

Laboratory for Neutron Scattering, Paul Scherrer Institut , CH-5232 PSI Villigen , Switzerland.

The evolution of interactions in the bovine serum albumin (BSA) protein solution on addition of mono and multivalent (di, tri and tetra) counterions has been studied using small-angle neutron scattering (SANS), dynamic light scattering (DLS) and ζ-potential measurements. It is found that in the presence of mono and divalent counterions, protein behavior can be well explained by DLVO theory, combining the contributions of screened Coulomb repulsion with the van der Waals attraction. The addition of mono or divalent salts in protein solution reduces the repulsive barrier and hence the overall interaction becomes attractive, but the system remains in one-phase for the entire concentration range of the salts, added in the system. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00374DOI Listing
April 2019
3 Reads

Formation of Nanofibrous Structure in Biopolymer Aerogel during Supercritical CO Processing: The Case of Chitosan Aerogel.

Biomacromolecules 2019 Apr 4. Epub 2019 Apr 4.

Research Institute for Chemical Process Technology , National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba 3058565 , Japan.

Supercritical drying is widely considered as the gold standard to produce aerogels that preserve the microstructure of the gels, but we have found this is not always the case. Chitosan aerogel, one of the emerging biopolymer aerogels, was prepared by chemical cross-linking gelation, followed by solvent exchange with methanol and supercritical drying using CO. Small-angle X-ray scattering analysis shows that the structure of the wet gel, which consists of Gaussian chains of individual molecular strands, converts into a nanofibrous network during CO processing. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00246DOI Listing
April 2019
3 Reads

High-Strength and Tough Cellulose Hydrogels Chemically Dual Cross-Linked by Using Low- and High-Molecular-Weight Cross-Linkers.

Biomacromolecules 2019 Apr 4. Epub 2019 Apr 4.

College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China.

Hydrogels are the focus of extensive research interests due to their potential application in the fields of biomedical materials, biosensors, agriculture, and cosmetics. Natural polysaccharide is one of the good candidates of these hydrogels. However, weak mechanical properties of cellulose hydrogels greatly limit their practical application. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00204
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http://dx.doi.org/10.1021/acs.biomac.9b00204DOI Listing
April 2019
10 Reads

Tumor Chemosensitization through Oncogene Knockdown Mediated by Unique α-Tocopherylated Cationic Geminis.

Biomacromolecules 2019 Apr 25;20(4):1555-1566. Epub 2019 Mar 25.

Department of Organic Chemistry , Indian Institute of Science , Bangalore 560012 , India.

Herein, siRNA transfection efficiency of a unique set of α-tocopherylated gemini lipids has been established in vitro and in vivo. High efficacy of oncogene silencing achieved using the biomacromolecular assembly, formed from siRNA complexes of co-liposomes containing an α-tocopherylated gemini lipid, has been utilized for tumor regression via chemosensitization. Delivery studies with the gemini bearing hydroxyethyl headgroup with octamethylene spacer (TH8S) pointed to a higher siRNA transfection efficacy than its analog without hydroxyethyl group (T8S). Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01751DOI Listing
April 2019
5.750 Impact Factor

Influence of Cellulose Charge on Bacteria Adhesion and Viability to PVAm/CNF/PVAm-Modified Cellulose Model Surfaces.

Biomacromolecules 2019 Apr 10. Epub 2019 Apr 10.

Department of Fibre and Polymer Technology, School of Engineering Science in Chemistry, Biotechnology and Health (CBH) , KTH Royal Institute of Technology . Teknikringen 56-58 , Stockholm 100 44 , Sweden.

A contact-active antibacterial approach based on the physical adsorption of a cationic polyelectrolyte onto the surface of a cellulose material is today regarded as an environment-friendly way of creating antibacterial surfaces and materials. In this approach, the electrostatic charge of the treated surfaces is considered to be an important factor for the level of bacteria adsorption and deactivation/killing of the bacteria. In order to clarify the influence of surface charge density of the cellulose on bacteria adsorption as well as on their viability, bacteria were adsorbed onto cellulose model surfaces, which were modified by physically adsorbed cationic polyelectrolytes to create surfaces with different positive charge densities. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00297DOI Listing

Oligoarginine-Bearing Tandem Repeat Penetration-Accelerating Sequence Delivers Protein to Cytosol via Caveolae-Mediated Endocytosis.

Biomacromolecules 2019 Apr 1. Epub 2019 Apr 1.

Institute for Chemical Research , Kyoto University , Uji , Kyoto 611-0011 , Japan.

To facilitate the cytosolic delivery of larger molecules such as proteins, we developed a new cell-penetrating peptide sequence, named Pas2r12, consisting of a repeated Pas sequence (FFLIG-FFLIG) and d-dodeca-arginine (r12). This peptide significantly enhanced the cellular uptake and cytosolic release of enhanced green fluorescent protein and immunoglobulin G as cargos. We found that simply mixing Pas2r12 with cargos could generate cytosolic introducible forms. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01299DOI Listing
April 2019
3 Reads

Digestive Enzyme Corona Formed in the Gastrointestinal Tract and Its Impact on Epithelial Cell Uptake of Nanoparticles.

Biomacromolecules 2019 Apr 28;20(4):1789-1797. Epub 2019 Mar 28.

Department of Pharmacy, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen DK-2100 , Denmark.

The fate of intravenously injected nanoparticles (NPs) is significantly affected by nano-protein interaction and corona formation. However, such an interaction between NPs and digestive enzymes occurring in the gastrointestinal tract (GIT) and its impacts on epithelial cell uptake are little known. We synthesized the poly(3-hydroxybutyrate- co-3-hydroxyhexanoate)-based cationic NPs (CNPs) and investigated the CNP-digestive enzyme interaction and its effect on the cellular uptake. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.9b00175
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http://dx.doi.org/10.1021/acs.biomac.9b00175DOI Listing
April 2019
12 Reads

All-Aqueous SI-ARGET ATRP from Cellulose Nanofibrils Using Hydrophilic and Hydrophobic Monomers.

Biomacromolecules 2019 Apr 2. Epub 2019 Apr 2.

An all-water-based procedure for "controlled" polymer grafting from cellulose nanofibrils is reported. Polymers and copolymers of poly(ethylene glycol) methyl ether methacrylate (POEGMA) and poly(methyl methacrylate) (PMMA) were synthesized by surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (SI-ARGET ATRP) from the cellulose nanofibril (CNF) surface in water. A macroinitiator was electrostatically immobilized to the CNF surface, and its amphiphilic nature enabled polymerizations of both hydrophobic and hydrophilic monomers in water. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00153DOI Listing
April 2019
2 Reads

ROS-Responsive Nanoparticles for Suppressing the Cytotoxicity and Immunogenicity Caused by PM2.5 Particulates.

Biomacromolecules 2019 Apr 27;20(4):1777-1788. Epub 2019 Mar 27.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , China.

Although the negative impacts of particulate matter (PM2.5) on human health have been well recognized, very few efforts have been paid to find new strategies to suppress the toxicity of PM2.5 both in vitro and in vivo. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00174DOI Listing
April 2019
2 Reads

Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG-PLGA Nanoparticles for Combination Chemotherapy.

Biomacromolecules 2019 Apr 26;20(4):1683-1690. Epub 2019 Mar 26.

The simultaneous delivery of multiple therapeutics to a single site has shown promise for cancer targeting and treatment. However, because of the inherent differences in charge and size between drugs and biomolecules, new approaches are required for colocalization of unlike components in one delivery vehicle. In this work, we demonstrate that triblock copolymers containing click nucleic acids (CNAs) can be used to simultaneously load a prodrug enzyme (cytosine deaminase, CodA) and a chemotherapy drug (doxorubicin, DOX) in a single polymer nanoparticle. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00040DOI Listing

SET-LRP of Bio- and Petroleum-Sourced Methacrylates in Aqueous Alcoholic Mixtures.

Biomacromolecules 2019 Apr 27;20(4):1816-1827. Epub 2019 Mar 27.

Roy & Diana Vagelos Laboratories, Department of Chemistry , University of Pennsylvania , Philadelphia , Pennsylvania 19104-6323 , United States.

Single-electron transfer-living radical polymerization (SET-LRP) in "programmed" aqueous organic biphasic systems eliminates the judicious choice of solvent and also provides accelerated reaction rates. Herein, we report efforts to expand the monomer scope for these systems by targeting methacrylic monomers and polymers. Various environmentally friendly aqueous alcoholic mixtures were used in combination with Cu(0) wire catalyst, tris(2-dimethylaminoethyl)amine (Me-TREN) ligand, and p-toluenesulfonyl chloride (Ts-Cl) initiator to deliver well-defined polymethacrylates from methyl methacrylate, butyl methacrylate, and other monomers derived from biomass feedstock (e. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00257DOI Listing
April 2019
1 Read

Versatile N-Methylaminooxy-Functionalized Polypeptides for Preparation of Neoglycoconjugates.

Biomacromolecules 2019 Apr 26;20(4):1756-1764. Epub 2019 Mar 26.

The preparation and characterization of a new set of well-defined polypeptides containing N-methylaminooxy side-chain functionality is described. These functional groups enabled the direct coupling of polypeptides with a variety of unmodified reducing saccharides in water to give neoglycopolypeptides in high yields. The use of different polypeptide scaffolds resulted in neoglycoconjugates with tunable chain conformations, hydrophobicity, and charge. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00138DOI Listing
April 2019
2 Reads

Active Modulation of States of Prestress in Self-Assembled Short Peptide Gels.

Biomacromolecules 2019 Apr 21;20(4):1719-1730. Epub 2019 Mar 21.

Centre for Bioengineering and Biotechnology , China University of Petroleum (East China) , 66 Changjiang West Road , Qingdao 266580 , China.

Peptide hydrogels are excellent candidates for medical therapeutics due to their tuneable viscoelastic properties, however, in vivo they will be subject to various osmotic pressures, temperature changes, and biological co-solutes, which could alter their performance. Peptide hydrogels formed from the synthetic peptide IK have a temperature-induced hardening of their shear modulus by a factor of 2. We show that the addition of uncross-linked poly( N-isopropylacrylamide) chains to the peptide gels increases the gels' temperature sensitivity by 3 orders of magnitude through the control of osmotic swelling and cross-linking. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00085DOI Listing
April 2019
1 Read

Minimal Reconstitution of Membranous Web Induced by a Vesicle-Peptide Sol-Gel Transition.

Biomacromolecules 2019 Apr 26;20(4):1709-1718. Epub 2019 Mar 26.

Centre for Biomimetic Sensor Science , Nanyang Technological University , 50 Nanyang Drive 637553 , Singapore.

Positive strand RNA viruses replicate in specialized niches called membranous web within the cytoplasm of host cells. These virus replication organelles sequester viral proteins, RNA, and a variety of host factors within a fluid, amorphous matrix of clusters of endoplasmic reticulum (ER) derived vesicles. They are thought to form by the actions of a nonstructural viral protein NS4B, which remodels the ER and produces dense lipid-protein condensates. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00081DOI Listing
April 2019
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Biocompatibility of Resorbable Polymers: A Historical Perspective and Framework for the Future.

Biomacromolecules 2019 Apr 20;20(4):1465-1477. Epub 2019 Mar 20.

Department of Fibre and Polymer Technology , KTH Royal Institute of Technology , 114 28 Stockholm , Sweden.

The history of resorbable polymers containing glycolide, lactide, ε-caprolactone and trimethylene carbonate, with a special emphasis being placed on the time frame of the 1960s-1990s is described. Reviewing the history is valuable when looking into the future perspectives regarding how and where these monomers should be used. This story includes scientific evaluations indicating that these polymers are safe to use in medical devices, while the design of the medical device is not considered in this report. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00159DOI Listing
April 2019
6 Reads

Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule.

Biomacromolecules 2019 Apr 15;20(4):1644-1654. Epub 2019 Mar 15.

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences , University of Shizuoka , 52-1 Yada, Suruga-ku , Shizuoka , Shizuoka 422-8526 , Japan.

Synthetic polymers are of interest as stable and cost-effective biomolecule-affinity reagents, since these polymers interact with target biomolecules both in vitro and in the bloodstream. However, little has been reported about orally administered polymers capable of capturing a target molecule and inhibiting its intestinal absorption. Here, we describe the design of synthetic polymer nanoparticles (NPs) specifically capturing indole, a major factor exacerbating chronic kidney disease, in the intestine. Read More

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b01820
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http://dx.doi.org/10.1021/acs.biomac.8b01820DOI Listing
April 2019
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Biosynthesis and Function of Long Guluronic Acid-Blocks in Alginate Produced by Azotobacter vinelandii.

Biomacromolecules 2019 Apr 19;20(4):1613-1622. Epub 2019 Mar 19.

Department of Biotechnology and Food Science , Norwegian University of Science and Technology, NTNU , Sem Sælands vei 6-8 , N-7491 Trondheim , Norway.

With the present accessibility of algal raw material, microbial alginates as a source for strong gelling material are evaluated as an alternative for advanced applications. Recently, we have shown that alginate from algal sources all contain a fraction of very long G-blocks (VLG), that is, consecutive sequences of guluronic acid (G) residues of more than 100 residues. By comparing the gelling properties of these materials with in vitro epimerized polymannuronic acid (poly-M) with shorter G-blocks, but comparable with the G-content, we could demonstrate that VLG have a large influence on gelling properties. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01796DOI Listing
April 2019
2 Reads

Structure-Activity Study of Antibacterial Poly(ester urethane)s with Uniform Distribution of Hydrophobic and Cationic Groups.

Biomacromolecules 2019 Apr 21;20(4):1675-1682. Epub 2019 Mar 21.

Infections associated with antibiotic-resistant bacteria have become a threat to the global public health. Antimicrobial polymers, which are synthetic mimics of antimicrobial peptides, have gained increasing attention, as they may have a lower chance of inducing resistance. The cationic-hydrophobic balance and distribution of cationic and hydrophobic moieties of these polymers is known to have a major effect on antimicrobial activity. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00029DOI Listing
April 2019
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Tissue-Engineered Trachea Consisting of Electrospun Patterned sc-PLA/GO- g-IL Fibrous Membranes with Antibacterial Property and 3D-Printed Skeletons with Elasticity.

Biomacromolecules 2019 Apr 19;20(4):1765-1776. Epub 2019 Mar 19.

Department of Applied Chemistry, School of Natural and Applied Sciences , Northwestern Polytechnical University , Xi'an 710129 , People's Republic of China.

In this study, a tissue-engineered trachea, consisting of multilevel structural electrospun polylactide (PLA) membranes enveloping 3D-printed thermoplastic polyurethane (TPU) skeletons, was developed to create a mechanically robust, antibacterial and bioresorbable graft for the tracheal reconstruction. The study design incorporated two distinct uses of stereocomplex PLA: patterned electrospun fibers to enhance tissue integration compared to the random layered fibers, meanwhile possessing good antibacterial property; and 3D-printed TPU scaffold with elasticity to provide external support and protection. Herein, ionic liquid (IL)-functioned graphene oxide (GO) was synthesized and presented enhanced mechanical and hydrophilicity properties. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00160DOI Listing

Synthesis of an Oxidation-Sensitive Polyphosphoester Bearing Thioether Group for Triggered Drug Release.

Biomacromolecules 2019 Apr 19;20(4):1740-1747. Epub 2019 Mar 19.

National Engineering Research Center for Tissue Restoration and Reconstruction , South China University of Technology , Guangzhou 510006 , China.

In this work, novel amphiphilic diblock copolymers of polyethylene glycol and polyphosphoester with pendant thioether groups, denoted as mPEG- b-PMSPEP, were synthesized through the ring-opening polymerization of functionalized cyclic phosphoester monomer using methoxy poly(ethylene glycol) and Sn(Oct) as the macroinitiator and catalyst, respectively. The successful synthesis was confirmed by H, C, P nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). These amphiphilic block copolymers self-assembled spontaneously in the aqueous solution, and the formed nanoparticles were sensitive to the oxidation that induced the hydrophobic to hydrophilic transition for its PMSPEP core under triggering of HO and the subsequent dissociation of the nanoparticles. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00101DOI Listing
April 2019
2 Reads

Thermosensitive Hydrogels as Scaffolds for Cartilage Tissue Engineering.

Biomacromolecules 2019 Apr 20;20(4):1478-1492. Epub 2019 Mar 20.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Street , Changchun 130022 , P. R. China.

Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clinical treatments, including autogenous and allograft osteochondral transplantation, microfracture technique, and so forth, have shown some efficacies, their drawbacks, such as donor insufficiency and poor-integration with adjacent tissue, limit the satisfactory repair of articular cartilage defects and cause unsatisfied prognosis. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00043DOI Listing
April 2019
2 Reads
5.750 Impact Factor

AFM Study on Superlubricity between Ti6Al4V/Polymer Surfaces Achieved with Liposomes.

Biomacromolecules 2019 Apr 13;20(4):1522-1529. Epub 2019 Mar 13.

State Key Laboratory of Tribology , Tsinghua University , Beijing 100084 , China.

Liposomes have been considered as the boundary lubricant in natural joints. They are also the main component of bionic lubricant. In this study, the tribological properties of liposomes on Ti6Al4V/polymer surface were studied by atomic force microscope (AFM) at the nanoscale. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01683DOI Listing
April 2019
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Distribution of Ionizable Groups in Polyampholyte Microgels Controls Interactions with Captured Proteins: From Blockade and "Levitation" to Accelerated Release.

Biomacromolecules 2019 Apr 18;20(4):1578-1591. Epub 2019 Mar 18.

DWI-Leibniz Institute for Interactive Materials e.V. , Forckenbeckstraße 50 , 52074 Aachen , Germany.

A striking discovery in our work is that the distribution of ionizable groups in polyampholyte microgels (random and core-shell) controls the interactions with the captured proteins. Polyampholyte microgels are capable to switch reversibly their charges from positive to negative depending on pH. In this work, we synthesized differently structured polyampholyte microgels with controlled amounts and different distribution of acidic and basic moieties as colloidal carriers to study the loading and release of the model protein cytochrome c (cyt-c). Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01775DOI Listing
April 2019
6 Reads

Inhibiting Ice Recrystallization by Nanocelluloses.

Biomacromolecules 2019 Apr 12;20(4):1667-1674. Epub 2019 Mar 12.

Department of Food Science , University of Tennessee , 2510 River Drive , Knoxville , Tennessee 37996 , United States.

Biocompatible materials with ice recrystallization inhibition (IRI) activity have potential applications in several fields. Emerging studies have associated the IRI activity of antifreeze proteins/glycoproteins and several mimics of synthetic materials with a facially amphipathic structure. Nanocelluloses are a new family of renewable materials that demonstrate amphiphilicity. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00027DOI Listing
April 2019
1 Read
5.750 Impact Factor